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PaRDeS, the journal of the German Association for Jewish Studies, aims at exploring the fruitful and multifarious cultures of Judaism as well as their relations to their environment within diverse areas of research. In addition, the journal promotes Jewish Studies within academic discourse and reflects on its historic and social responsibilities.
Bericht über die Arbeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2002 - Teil I • Der Menschenrechtskommissar des Europarats • Türkei widersetzt sich weiterhin einem Urteil des Europäischen Gerichtshofs für Menschenrechte • Menschenrechtskammer für Bosnien-Herzegowina: Hadz Boudellaa u. a../. Bosnien-Herzegowina und die Föderation von Bosnien-Herzegowina
Halbzeit der Amtszeit
(2003)
The centrosome is the main microtubule-organizing center and constitutes the largest protein complex in a eukaryotic cell. The Dictyostelium centrosome is an established model for acentriolar centrosomes and it consists of a layered core structure Surrounded by a so-called corona, which harbors microtubule nucleation complexes. We have identified 34 new centrosomal candidate proteins through mass spectrometrical analysis of the proteome of isolated Dictyostelium centrosomes. Here we present a characterization of 12 centrosomal candidate proteins all featuring coiled coil regions and low expression levels, which are the most common attributes of centrosomal proteins. We used GFP fusion proteins to localize the candidate proteins in whole cells and on microtubule-free, isolated centrosomes. Thus we were able to identify nine new genuine centrosomal proteins including a putative orthologue of Cep192, an interaction partner of polo-like kinase 4 in human centriole biogenesis. In this respect, centrosomal localization of the only polo-like kinase in Dictyostelium, Pik, is also shown in this work. Using confocal deconvolution microscopy, four components, CP39, CP55, CP75, and CP91 could be clearly assigned to the so far almost uncharacterized centrosomal core structure, while CP148 and Cep192 localized to a zone between that of corona marker and core proteins. Finally, CP103 and CP248 were constituents of the corona. In contrast, NE81 was localized at the nuclear envelope and three others, an orthologue of the spindle checkpoint component Mad1, the novel Cenp68, and the centrosomal CP248 were observed at the centromeres, which are clustered and linked to the centrosome throughout the entire cell cycle. Cell Motil. Cytoskeleton 66: 915-928, 2009.
Cell cycle-dependent localization of novel centrosomal and centromeric proteins in Dictyostelium
(2009)
Der Schutz der Menschenrechte in bewaffneten Konflikten • Zur Umsetzung der „Erklärung zu den Menschenrechtsverteidigern" fünf Jahre nach ihrer Verabschiedung - eine Bestandsaufnahme • Der Fall Judge - Menschenrechtsausschuß ändert seine Rechtsprechung zu Art. 6 IPbpR • Dokumentation: Menschenrechtspreise (Fortsetzung)
Der Streit um das Kopftuch - Plädoyer für eine aktive Neutralität • Die Kultur der Menschenrechte - Eine Bestandsaufnahme aus philosophischer Sicht • 165 Jahre Einschränkung der Kinderarbeit in Preußen: Ein Beitrag zur Sozialgesetzgebung in Deutschland • Die völkerstrafrechtliche Beurteilung der Verfolgung von Falun Gong seit 1999