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Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
To investigate if magnetic fields are present in Wolf-Rayet stars, we selected a few stars in the Galaxy and one in the Large Magellanic Cloud (LMC). We acquired low-resolution spectropolarimetric observations with the European Southern Observatory FORS 2 (FOcal Reducer low dispersion Spectrograph) instrument during two different observing runs. During the first run in visitor mode, we observed the LMC Wolf-Rayet star BAT99 7 and the stars WR 6, WR 7, WR 18, and WR 23 in our Galaxy. The second run in service mode was focused on monitoring the star WR 6. Linear polarization was recorded immediately after the observations of circular polarization. During our visitor observing run, the magnetic field for the cyclically variable star WR 6 was measured at a significance level of 3.3 sigma (< B-z > = 258 +/- 78 G). Among the other targets, the highest value for the longitudinal magnetic field, < B-z > = 327 +/- 141 G, was measured in the LMC star BAT99 7. Spectropolarimetric monitoring of the star WR 6 revealed a sinusoidal nature of the < B-z > variations with the known rotation period of 3.77 d, significantly adding to the confidence in the detection. The presence of the rotation-modulated magnetic variability is also indicated in our frequency periodogram. The reported field magnitude suffers from significant systematic uncertainties at the factor of 2 level, in addition to the quoted statistical uncertainties, owing to the theoretical approach used to characterize it. Linear polarization measurements showed no line effect in the stars, apart from WR 6. BAT99 7, WR 7, and WR 23 do not show variability of the linear polarization over two nights.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
(2019)
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.