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In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.
Wild birds are considered a potential reservoir or a carrier of viral diseases and may therefore play a role in the epidemiology of economically important or zoonotic diseases. In 2001 and 2002, a survey with special emphasis oil virus isolation in migrating waders and some other birds were conducted. In one of the most important inland resting sites for migratory waterfowl, tracheal and cloacal swabs were collected from 465 waders representing 19 different species, and 165 other birds that were not captured on purpose. A total of 42 avian viruses were isolated, 34 of these were identified as paramyxoviruses (PMVs). The majority of isolates came from waders and wild ducks, and were characterized as PMV-1. In contrast, PMV-4 was found in wild ducks only, PMV-6 was mainly detected in wader species. Four avian influenza viruses (ATVs), belonging to H4 and H3 haemagglutinin subtype, were isolated from wild duck species. Furthermore, four reo-like viruses were isolated from one particular wader species for the first time. The majority of virus positive birds were < 1 year old and did not show any clinical symptoms. There was no evidence for the presence of West Nile virus in these birds. These results confirm that the restricted resting sites in Western Europe must be considered as important locations for the intra- and interspecies transmission of avian viruses
Computational methods for the design of effective therapies against drug resistant HIV strains
(2005)
The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data
Spätholozäne Landschaftsentwicklung in Westchina : zwei Fallbeispiele aus der Provinz Qinghai
(2004)
Zusammenfassung Neuere archäologische Forschungsergebnisse belegen, dass seit der frühen Bronzezeit ein intensiver kultureller und wirtschaftlicher Austausch zwischen West- und Südostchina bestand. Es war anzunehmen, dass die Grundlage dieses Austausches vergleichsweise weit entwickelte Landnutzungsaktivitäten waren. Geoarchäologische Untersuchungen über die Umweltauswirkungen der bronzezeitlichen Landnutzung in Westchina fehlen bisher. An zwei Fallbeispielen in der Provinz Qinghai, den archäologischen Fundplätzen Lajia und Fengtai, wird aufgezeigt, dass dort die wirtschaftliche Wertschöpfung auf vergleichsweise intensiver Landnutzung basierte. Die damit verbundene Zerstörung der natürlichen Vegetation ermöglichte katastrophale Erosionsereignisse, die zum Niedergang beider Siedlungen führten. Abstract Late Holocene Landscape Development in Western China ; Two Case Studies from Qinghai Province Recent archaeological research results show that an intensive cultural as well as economic exchange took place between Western and South-Eastern China since early Bronze Age. It can be assumed, that the exchange based on comparatively well developed land use activities. Geo-archaeological investigations concerning the environmental impact of Bronze Time land use in Western China are missing so far. Two case studies about the archaeological sites Lajia and Fengtai located in Qinghai Province show, that the creation of economic value based on comparatively intensive land use. The associated clearing of natural vegetation caused disastrous erosion events, which led to the decline of both settlements.
- Ulrike Leitner: Aus dem Humboldt-Nachlaß: Juan José de Oteyzas Beschreibung der Pyramiden von Teotihuacán
- Ottmar Ette: Alexander von Humboldt, die Humboldtsche Wissenschaft und ihre Relevanz im Netzzeitalter
- Bernd Kölbel, Martin Sauerwein, Katrin Sauerwein, Steffen Kölbel und Lucie Terken: Alexander von Humboldt und seine geognostischen Studien in Göttingen
- Nicolaas A. Rupke: A Metabiography of Alexander von Humboldt
- Franz-J. Weihrauch: Nachrichten aus Amerika oder wie man in Koblenz von Humboldts Reise nach Amerika erfuhr
- Petra Werner Himmelsblau. Bemerkungen zum Thema „Farben“ in Humboldts Alterswerk Kosmos. Entwurf einer physischen Weltbeschreibung
- Robert Hoffmann: Die Entstehung einer Legende. Alexander von Humboldts angeblicher Ausspruch über Salzburg.
Aus dem Inhalt: - Neue Entwicklungen im regionalen Menschenrechtsschutz: eine politikwissenschaftliche Betrachtung des institutionellen Designs und der Dynamik des derzeitigen menschenrechtlichen Regionalismus - Das menschenrechtliche Diskriminierungsverbot und seine Grenzen - Die Individualbeschwerde zur Kinderrechtskonvention - BVerfG: Fraport – Urteil vom 22. Februar 2011
Environmental parameters such as rainfall, temperature and relative humidity can affect the composition of higher plant leaf wax. The abundance and distribution of leaf wax biomarkers, such as long chain n-alkanes, in sedimentary archives have therefore been proposed as proxies reflecting climate change. However, a robust palaeoclimatic interpretation requires a thorough understanding of how environmental changes affect leaf wax n-alkane distributions in living plants. We have analysed the concentration and chain length distribution of leaf wax n-alkanes in Acacia and Eucalyptus species along a 1500 km climatic gradient in northern Australia that ranges from subtropical to arid. We show that aridity affected the concentration and distribution of n-alkanes for plants in both genera. For both Acacia and Eucalyptus n-alkane concentration increased by a factor of ten to the dry centre of Australia, reflecting the purpose of the wax in preventing water loss from the leaf. Furthermore, Acacian-alkanes decreased in average chain length (ACL) towards the arid centre of Australia, whereas Eucalyptus ACL increased under arid conditions. Our observations demonstrate that n-alkane concentration and distribution in leaf wax are sensitive to hydroclimatic conditions. These parameters could therefore potentially be employed in palaeorecords to estimate past environmental change. However, our finding of a distinct response of n-alkane ACL values to hydrological changes in different taxa also implies that the often assumed increase in ACL under drier conditions is not a robust feature for all plant species and genera and as such additional information about the prevalent vegetation are required when ACL values are used as a palaeoclimate proxy.
A dual probe was investigated by UV-Vis, fluorescence, and ESR spectroscopy. It comprises the pyrene chromophore and the paramagnetic 2,2,6,6-tetramethylpiperidinyl-N-oxyl radical that are covalently linked together via an ester bridge. The dual probe was used to investigate molecular solvents of different polarity as well as ionic liquids bearing either imidazolium or pyrrolidinium cations and various anions, such as bis(trifluoromethylsulfonyl)imide, tetrafluoroborate, tris(pentafluoroethyl)trifluorophosphate, or dicyanamide. The dual probe does not show solvatochromism that is typical for some pyrenes. Furthermore, the dual probe is considerable less mobile compared to 2,2,6,6-tetramethylpiperidinyl-N-oxyl (TEMPO) without additional substituent as detected by ESR spectroscopy. This is caused by the bulky pyrenyl substituent bound at the dual probe resulting in a reduced mobility of the dual probe.
To identify copper homeostasis genes in Rhodobacter capsulatus, we performed random transposon Tn5 mutagenesis. Screening of more than 10,000 Tn5 mutants identified tellurite resistance gene trgB as a so far unrecognized major copper tolerance determinant. The trgB gene is flanked by tellurite resistance gene trgA and cysteine synthase gene cysK2. While growth of trgA mutants was only moderately restricted by tellurite, trgB and cysK2 mutants were severely affected by tellurite, which implies that viability under tellurite stress requires increased cysteine levels. Mutational analyses revealed that trgB was the only gene in this chromosomal region conferring cross-tolerance towards copper. Expression of the monocistronic trgB gene required promoter elements overlapping the trgA coding region as shown by nested deletions. Neither copper nor tellurite affected trgB transcription as demonstrated by reverse transcriptase PCR and trgB-lacZ fusions. Addition of tellurite or copper gave rise to increased cellular tellurium and copper concentrations, respectively, as determined by inductively coupled plasma-optical emission spectroscopy. By contrast, cellular iron concentrations remained fairly constant irrespective of tellurite or copper addition. This is the first study demonstrating a direct link between copper and tellurite response in bacteria.