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Networks are widely used across many fields to represent interactions, such as the web, social interactions, infrastructure, or biological connections. Algorithms and processes on these networks have many uses, for example to find the shortest path in a road network, or to understand the spreading of information through a social network. In order to better answer such questions, we should understand how algorithms and processes are affected by features of the networks. One useful tool for this can be found in random network models, serving as proxies for real-world networks. Their features can be controlled via model parameters. While these models are usually easier to understand and analyze than real-world networks, their usefulness depends on how realistic they are.
Thus, we look at well-known network models and evaluate whether they are useful for predicting algorithm behavior on real-world networks - the external validity. We focus on many widely-used algorithms and processes, and establish that the models are good proxies for real-world networks. We observe that heterogeneity and locality are important features for explaining and predicting algorithm behavior.
In order to use random network models as proxies for real-world networks or to investigate model fit, one should utilize the model configuration capabilities optimally. As the models can be configured via parameters that affect the network features, this entails choosing the best parameters for some target network features. However, the exact relation between the configuration and the resulting network features is not clear. We present a method for estimating the best-fitting parameter configuration for commonly used network models, given some target features of the resulting networks. Our iterative method based on stochastic approximation needs only few samples and works reliably across a range of parameter configurations.
Furthermore, we take a closer look at the features and substructures of networks. In particular, based on methods from clustering and outlier detection, we consider the idea that the edge set actually comes from two edge sets with differing features. With this idea, we investigate the well-known bootstrap percolation process on this combination of networks, which had previously only been considered on single network models. We theoretically and empirically consider the process on two combined network models, with differing percolation thresholds for the two edge sets, and see an interesting emerging behavior of a slow and a rapid percolation phase. In addition, we consider ways to separate edge sets based on locality features. Assuming the edges are a combination of two network models, we show how the edges can be separated by a simple metric, even with imbalanced set sizes.
Overall, we evaluate common random network models, improve methods to utilize them, and contribute towards the design and understanding of new, combined network models.
Iconographic evidence from Egypt suggests that watermelon pulp was consumed there as a dessert by 4,360 BP.
Earlier archaeobotanical evidence comes from seeds from Neolithic settlements in Libya, but whether these were watermelons with sweet pulp or other forms is unknown.
We generated genome sequences from 6,000- and 3,300-year-old seeds from Libya and Sudan, and from worldwide herbarium collections made between 1824 and 2019, and analyzed these data together with resequenced genomes from important germplasm collections for a total of 131 accessions.
Phylogenomic and population-genomic analyses reveal that (1) much of the nuclear genome of both ancient seeds is traceable to West African seed-use "egusi-type" watermelon (Citrullus mucosospermus) rather than domesticated pulp-use watermelon (Citrullus lanatus ssp. vulgaris); (2) the 6,000-year-old watermelon likely had bitter pulp and greenish-white flesh as today found in C. mucosospermus, given alleles in the bitterness regulators ClBT and in the red color marker LYCB; and (3) both ancient genomes showed admixture from C. mucosospermus, C. lanatus ssp. cordophanus, C. lanatus ssp. vulgaris, and even South African Citrullus amarus, and evident introgression between the Libyan seed (UMB-6) and populations of C. lanatus.
An unexpected new insight is that Citrullus appears to have initially been collected or cultivated for its seeds, not its flesh, consistent with seed damage patterns induced by human teeth in the oldest Libyan material.
Detailed microstructural analysis of three basaltic sills of the Little Minch Sill Complex demonstrates that convection leaves a detectable signature in fully solidified bodies. The presence of dense clusters of equant grains of olivine and clinopyroxene in the central parts of sills can only be accounted for if they formed and were enlarged while suspended in convecting magma, with delayed settling to the sill floor.
An associated stratigraphic invariance of plagioclase grain shape is consistent with growth while suspended in convecting magma.
These microstructural indicators demonstrate that convection during solidification was vigorous and long-lived in the 135-m-thick picrodolerite-crinanite unit (PCU) of the composite Shiant Isles Main sill and vigorous and likely short-lived in the PCU of the composite Creagan Iar sill.
In contrast, convection in the Meall Tuath sill was weak and short-lived: plagioclase grain shape in this sill varies with stratigraphic height, indicative of primarily in situ nucleation and growth at the magma-mush interface, while olivine and clinopyroxene were kept suspended in the overlying convecting magma.
The magma in all three sills fractionated during solidification, permitting convection driven by the instability of an upper thermal boundary layer.
The comparative vigour and longevity of convection in the Shiant Isles Main sill and the Creagan Iar sill was due to their emplacement above an earlier, still-hot, intrusion, resulting in highly asymmetric cooling.
Motivation:
Limited data access has hindered the field of precision medicine from exploring its full potential, e.g. concerning machine learning and privacy and data protection rules. Our study evaluates the efficacy of federated Random Forests (FRF) models, focusing particularly on the heterogeneity within and between datasets. We addressed three common challenges: (i) number of parties, (ii) sizes of datasets and (iii) imbalanced phenotypes, evaluated on five biomedical datasets.
Results:
The FRF outperformed the average local models and performed comparably to the data-centralized models trained on the entire data. With an increasing number of models and decreasing dataset size, the performance of local models decreases drastically. The FRF, however, do not decrease significantly. When combining datasets of different sizes, the FRF vastly improve compared to the average local models. We demonstrate that the FRF remain more robust and outperform the local models by analyzing different class-imbalances. Our results support that FRF overcome boundaries of clinical research and enables collaborations across institutes without violating privacy or legal regulations. Clinicians benefit from a vast collection of unbiased data aggregated from different geographic locations, demographics and other varying factors. They can build more generalizable models to make better clinical decisions, which will have relevance, especially for patients in rural areas and rare or geographically uncommon diseases, enabling personalized treatment. In combination with secure multi-party computation, federated learning has the power to revolutionize clinical practice by increasing the accuracy and robustness of healthcare AI and thus paving the way for precision medicine.
Availability and implementation:
The implementation of the federated random forests can be found at https://fea
turecloud.ai/.
Visualising Southern African Late Iron Age Settlements in the Digital Age studies the visualisation of Southern African Late Iron Age Settlements (LIAS) (c. 900–1800) across the late nineteenth, twentieth, and early twenty-first centuries (1871–2020), as found in a survey of the cultural production, circulation, reproduction, and theorisation of illustrations accompanying archaeological, anthropological, and historical Southern African LIAS research. A valuable contribution of LIAS research is its continuous demonstration of a pre-colonial hub of cosmopolitanisms on a scale never imagined in colonial histories of 'indigenous' communities – thought of as the ultimate 'other' of global modernity.
This study focuses on the visualisation of four settlements, namely: Mapungubwe, Khami, Great Zimbabwe, and Bokoni. It is proposed that as with the authority of Eurocentric 'formative interpretations' of LIAS research currently under review, visualisations accompanying LIAS also need to be critically relooked at within appropriate visual cultural methodologies informed by postcolonial, decolonial and critical race theory. The study follows a two-fold methodological framework involving a textual analysis and an image-making process. On both accounts, the study focuses on the cultural politics of representation, asking: who and what is being made visible in the visualisation of settlements accompanying LIAS research; what forms of materiality and spatiality are pictured and performed; what is the affect such visualisations have on the people that experience them; and finally, what do they mean in the context in which they are made?
We demonstrate that tungsten disulphide (WS2) with thicknesses ranging from monolayer (ML) to several monolayers can be grown on SiO2/Si, Si, and Al2O3 by pulsed direct current-sputtering.
The presence of high quality monolayer and multilayered WS2 on the substrates is confirmed by Raman spectroscopy since the peak separations between the A(1g)-E-2g and A(1g)-2LA vibration modes exhibit a gradual increase depending on the number of layers. X-ray diffraction confirms a textured (001) growth of WS2 films.
The surface roughness measured with atomic force microscopy is between 1.5 and 3 angstrom for the ML films. The chemical composition WSx (x = 2.03 +/- 0.05) was determined from X-ray Photoelectron Spectroscopy.
Transmission electron microscopy was performed on a multilayer film to show the 2D layered structure. A unique method for growing 2D layers directly by sputtering opens up the way for designing 2D materials and batch production of high-uniformity and high-quality (stochiometric, large grain sizes, flatness) WS2 films, which will advance their practical applications in various fields.
Hellweger et al. (Reports, 27 May 2022, pp. 1001) predict that phosphorus limitation will increase concentrations of cyanobacterial toxins in lakes.
However, several molecular, physiological, and ecological mechanisms assumed in their models are poorly supported or contradicted by other studies.
We conclude that their take-home message that phosphorus load reduction will make Lake Erie more toxic is seriously flawed.
Background:
Inflammaging is considered to drive loss of muscle function. Omega-3 fatty acids exhibit anti-inflammatory properties. Therefore, we examined the effects of eight weeks of vibration and home-based resistance exercise combined with a whey-enriched, omega-3-supplemented diet on muscle power, inflammation and muscle biomarkers in community-dwelling old adults.
Methods:
Participants were randomized to either exercise (3x/week, n = 20), exercise + high-protein diet (1.2-1.5 g/kg, n = 20), or exercise + high-protein and omega-3-enriched diet (2.2 g/day, n = 21). Muscle power (watt/m(2)) and chair rise test (CRT) time (s) were assessed via CRT measured with mechanography. Furthermore, leg strength (kg/m(2)) and fasting concentrations of inflammatory (interleukin (IL-) 6, IL-10, high-mobility group box-1 (HMGB-1)) and muscle biomarkers (insulin-like growth factor (IGF-) 1, IGF-binding protein-3, myostatin) were assessed.
Results:
Sixty-one participants (70.6 +/- 4.7 years; 47% men) completed the study. According to generalized linear mixed models, a high-protein diet improved leg strength and CRT time. Only IGF-1 increased with additional omega-3. Sex-specific analyses revealed that muscle power, IL-6, IL-6/IL-10 ratio, and HMGB-1 improved significantly in the male high-protein, omega-3-enriched group only.
Conclusion:
Vibration and home-based resistance exercise combined with a high-protein, omega-3-enriched diet increased muscle power and reduced inflammation in old men, but not in old women. While muscle biomarkers remained unchanged, a high-protein diet combined with exercise improved leg strength and CRT time.