Moving in the Anthropocene
(2018)
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
Conventional wisdom since the earliest studies of Irish English has attributed much of what is distinctive about this variety to the influence of the Irish language. From the early philologists (Joyce 1910, van Hamel 1912) through the classic works of Henry (1957, 1958) and Bliss (1979) down to present-day linguistic orientations (e.g. Corrigan 2000 a, Filppula 1999, Fiess 2000, Hickey 2000, Todd 1999, and others), the question of Irish-language influence may be disputed on points of detail, but remains a central focus for most studies in the field. It is not our intention to argue with this consensus, nor to examine specific points of grammar in detail, but, rather, to suggest an approach to this question which (a) takes for its empirical base a sample of the standard language, rather than dialectal material or the sample sentences so beloved of many papers on the subject, and (b) understands Celticity not just in terms of the formal transfer of grammatical features, but as an indexical feature of language use, i.e. one in which English in Ireland is used in such a way as to point to the Irish language as a linguistic and cultural reference point. In this sense, our understanding of Celticity is not entirely grammatical, but relies as well on Pierce’s notion of indexicality (see Greenlee 1973), by which semiotic signs ‘point to’ other signs. Our focus in assessing Celticity, then, derives in the first instance from an examination of the International Corpus of English (ICE). We have recently completed the publication of the Irish component of ICE (ICE-Ireland), a machinereadable corpus of over 1 million words of speech and writing gathered from a range of contexts determined by the protocols of the global International Corpus of English project. The international nature of this corpus project makes for ready comparisons with other varieties of English, and in this paper we will focus on comparisons with the British corpus, ICE-GB. For references on ICE generally, see Greenbaum 1996; for ICE-GB, see especially Nelson, Wallis and Aarts 2002; and for ICE-Ireland, see papers such as Kirk, Kallen, Lowry & Rooney (2003), Kirk & Kallen (2005), and Kallen & Kirk (2007). Our first approach will be to look for signs of overt Celticity in those grammatical features of Irish English which have been put forward as evidence of Celtic transfer (or of the reinforcement between Celtic and non-Celtic historical sources); our second approach will be to look at non-grammatical ways in which texts in ICEIreland become indexical of Celticity by less structural means such as loanwords, code-switching, and covert reference using ‘standard’ English in ways that are specific to Irish usage. We argue that, at least within the standard language as we have observed it, Celticity is at once less obvious than a reading of the dialectal literature might suggest and, at the same time, more pervasive than a purely grammatical approach would imply.
Irish standard English
(2006)
Ironsulfur clusters (ISCs) are important prosthetic groups that define the functions of many proteins. Proteins with ISCs (called ironsulfur or FeS proteins) are present in mitochondria, the cytosol, the endoplasmic reticulum and the nucleus. They participate in various biological pathways including oxidative phosphorylation (OXPHOS), the citric acid cycle, iron homeostasis, heme biosynthesis and DNA repair. Here, we report a homozygous mutation in LYRM4 in two patients with combined OXPHOS deficiency. LYRM4 encodes the ISD11 protein, which forms a complex with, and stabilizes, the sulfur donor NFS1. The homozygous mutation (c.203GT, p.R68L) was identified via massively parallel sequencing of 1000 mitochondrial genes (MitoExome sequencing) in a patient with deficiency of complexes I, II and III in muscle and liver. These three complexes contain ISCs. Sanger sequencing identified the same mutation in his similarly affected cousin, who had a more severe phenotype and died while a neonate. Complex IV was also deficient in her skeletal muscle. Several other FeS proteins were also affected in both patients, including the aconitases and ferrochelatase. Mutant ISD11 only partially complemented for an ISD11 deletion in yeast. Our in vitro studies showed that the l-cysteine desulfurase activity of NFS1 was barely present when co-expressed with mutant ISD11. Our findings are consistent with a defect in the early step of ISC assembly affecting a broad variety of FeS proteins. The differences in biochemical and clinical features between the two patients may relate to limited availability of cysteine in the newborn period and suggest a potential approach to therapy.