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Model-based and model-free decisions in alcohol dependence

  • Background: Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this in human alcohol dependence is as yet inconclusive. Methods: Twenty-six healthy controls and 26 recently detoxified alcohol-dependent patients underwent behavioral testing with a 2-step task designed to disentangle goal-directed and habitual response patterns. Results: Alcohol-dependent patients showed less evidence of goal-directed choices than healthy controls, particularly after losses. There was no difference in the strength of the habitual component. The group differences did not survive controlling for performance on the Digit Symbol Substitution Task. Conclusion: Chronic alcohol use appears to selectively impair goal-directed function, rather than promoting habitual responding. It appears to do so particularly after nonrewards, and this may be mediated by the effects of alcohol on more general cognitive functions subserved by the prefrontal cortex.

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Author details:Miriam Hannah SeboldORCiDGND, Lorenz Deserno, Stefan Nebe, Daniel SchadORCiDGND, Maria GarbusowORCiDGND, Claudia Haegele, Juergen Keller, Elisabeth Juenger, Norbert Kathmann, Michael N. SmolkaORCiDGND, Michael Armin RappORCiDGND, Florian SchlagenhaufORCiDGND, Andreas HeinzORCiDGND, Quentin J. M. HuysORCiD
DOI:https://doi.org/10.1159/000362840
ISSN:0302-282X
ISSN:1423-0224
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/25359492
Title of parent work (English):Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography
Publisher:Karger
Place of publishing:Basel
Publication type:Article
Language:English
Year of first publication:2014
Publication year:2014
Release date:2017/03/27
Tag:Alcohol dependence; Computational psychiatry; Decision-making; Dopamine; Reinforcement learning
Volume:70
Issue:2
Number of pages:10
First page:122
Last Page:131
Funding institution:German Research Foundation (DeutscheForschungsgemeinschaft) [HE2597/14-1, ZI1119/3-1, DFG RA1047/2-1]
Organizational units:Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie
Peer review:Referiert
Institution name at the time of the publication:Humanwissenschaftliche Fakultät / Institut für Psychologie
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