Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans
- Background: All living cells display a rapid molecular response to adverse environmental conditions, and the heat shock protein family reflects one such example. Hence, failing to activate heat shock proteins can impair the cellular response. In the present study, we evaluated whether the loss of different isoforms of heat shock protein (hsp) genes in Caenorhabditis elegans would affect their vulnerability to Manganese (Mn) toxicity. Conclusions: Taken together, our data suggest that Mn exposure modulates heat shock protein expression, particularly HSP-70, in C. elegans. Furthermore, loss of hsp-70 increases protein oxidation and dopaminergic neuronal degeneration following manganese exposure, which is associated with the inhibition of pink1 increased expression, thus potentially exacerbating the vulnerability to this metal.
Verfasserangaben: | Daiana Silva AvilaORCiD, Alexandre Benedetto, Catherine Au, Julia BornhorstORCiDGND, Michael A. Aschner |
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DOI: | https://doi.org/10.1186/s40360-016-0097-2 |
ISSN: | 2050-6511 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/27802836 |
Titel des übergeordneten Werks (Englisch): | Plant Methods |
Verlag: | BioMed Central |
Verlagsort: | London |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2016 |
Erscheinungsjahr: | 2016 |
Datum der Freischaltung: | 22.03.2020 |
Freies Schlagwort / Tag: | Caenorhabitis elegans; Heat shock proteins; Manganese; hsp-70; pink1 |
Band: | 17 |
Seitenanzahl: | 9 |
Fördernde Institution: | DFG [BO 4103/2-1]; CNPq/Universal Grant [453963/2014-5]; National Institute of Environmental Health Sciences (NIEHS) [R01 ES10563, R01 ES07331]; CNPq |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
Peer Review: | Referiert |