- Coronary artery disease (CAD) is the leading cause of death worldwide.
Statins reduce morbidity and mortality of CAD. Intake of n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic acid (EPA), is associated with reduced morbidity and mortality in patients with CAD. Previous data indicate that a higher conversion of precursor fatty acids (FAs) to arachidonic acid (AA) is associated with increased CAD prevalence.
Our study explored the FA composition in blood to assess n-3 PUFA levels from patients with and without CAD. We analyzed blood samples from 273 patients undergoing cardiac catheterization. Patients were stratified according to clinically relevant CAD (n = 192) and those without (n = 81). FA analysis in full blood was performed by gas chromatography. Indicating increased formation of AA from precursors, the ratio of dihomo-gamma-linolenic acid (DGLA) to AA, the delta-5 desaturase index (D5D index) was higher in CAD patients. CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6Coronary artery disease (CAD) is the leading cause of death worldwide.
Statins reduce morbidity and mortality of CAD. Intake of n-3 polyunsaturated fatty acid (n-3 PUFAs), particularly eicosapentaenoic acid (EPA), is associated with reduced morbidity and mortality in patients with CAD. Previous data indicate that a higher conversion of precursor fatty acids (FAs) to arachidonic acid (AA) is associated with increased CAD prevalence.
Our study explored the FA composition in blood to assess n-3 PUFA levels from patients with and without CAD. We analyzed blood samples from 273 patients undergoing cardiac catheterization. Patients were stratified according to clinically relevant CAD (n = 192) and those without (n = 81). FA analysis in full blood was performed by gas chromatography. Indicating increased formation of AA from precursors, the ratio of dihomo-gamma-linolenic acid (DGLA) to AA, the delta-5 desaturase index (D5D index) was higher in CAD patients. CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6 PUFA) and n-3 PUFA, particularly EPA, in the blood.
Thus, our study supports a role of increased EPA levels for cardioprotection.…
MetadatenAuthor details: | Chaoxuan WangORCiD, Jörg EnssleORCiD, Anne Pietzner, Christoph Schmöcker, Linda Weiland, Oliver RitterGND, Monique JaenschORCiDGND, Ulf ElbeltORCiDGND, Nikolaos PagonasGND, Karsten-Henrich WeylandtORCiDGND |
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DOI: | https://doi.org/10.3390/ijms23020766 |
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ISSN: | 1422-0067 |
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ISSN: | 1661-6596 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35054948 |
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Title of parent work (English): | International journal of molecular sciences |
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Publisher: | Molecular Diversity Preservation International |
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Place of publishing: | Basel |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/01/11 |
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Publication year: | 2022 |
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Release date: | 2024/06/06 |
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Tag: | arachidonic acid; coronary artery disease; n-3 PUFA; polyunsaturated fatty acids; statins; triglycerides |
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Volume: | 23 |
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Issue: | 2 |
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Article number: | 766 |
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Number of pages: | 14 |
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Funding institution: | University Hospital Ruppin, Brandenburg Medical School; Faculty of; Health Sciences Brandenburg |
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Organizational units: | Fakultät für Gesundheitswissenschaften |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Publishing method: | Open Access / Gold Open-Access |
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| DOAJ gelistet |
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License (German): | CC-BY - Namensnennung 4.0 International |
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