A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein
- Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan,inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA.
| Author details: | Muhammad ShahidGND, G. Manchi, Pavel SlunskyGND, O. Naseer, A. Fatima, B. Leo, Jens RailaORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1515/pjvs-2017-0024 |
| ISSN: | 1505-1773 |
| ISSN: | 2300-2557 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/28525322 |
| Title of parent work (English): | Polish journal of veterinary sciences : PJVS : the journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn |
| Publisher: | De Gruyter |
| Place of publishing: | Berlin |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2017 |
| Publication year: | 2017 |
| Release date: | 2023/01/06 |
| Tag: | biomarker; canine osteoarthritis; extra-cellular matrix; proteomix analysis; synovial fluid |
| Volume: | 20 |
| Issue: | 1 |
| Number of pages: | 13 |
| First page: | 189 |
| Last Page: | 201 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
| DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Peer review: | Referiert |
