2,2 '-Biphenols via protecting group-free thermal or microwave-accelerated suzuki-miyaura coupling in water
- User-friendly protocols for the protecting group-free synthesis of 2,2'-biphenols via Suzuki-Miyaura coupling of o-halophenols and o-boronophenol are presented. The reactions proceed in water in the presence of simple additives such as K2CO3, KOH, KF, or TBAF and with commercially available Pd/C as precatalyst. Expensive or laboriously synthesized ligands or other additives are not required. In the case of bromophenols, efficient rate acceleration and short reaction times were accomplished by microwave irradiation.
Author details: | Bernd SchmidtORCiDGND, Martin Riemer, Manfred KarrasORCiDGND |
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DOI: | https://doi.org/10.1021/jo401398n |
ISSN: | 0022-3263 |
Title of parent work (English): | The journal of organic chemistry |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Volume: | 78 |
Issue: | 17 |
Number of pages: | 9 |
First page: | 8680 |
Last Page: | 8688 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |