Mingjun Li, Lingyan Gao, Christoph Schlaich, Jianguang Zhang, Ievgen S. Donskyi, Guozhi Yu, Wenzhong Li, Zhaoxu Tu, Jens Rolff, Tanja Schwerdtle, Rainer Haag, Nan Ma
- A novel surface coating with durable broad-spectrum antibacterial ability was prepared based on mussel inspired dendritic polyglycerol (MI-dPG) embedded with copper nanoparticles (Cu NPs). The functional surface coating is fabricated via a facile dip-coating process followed by in situ reduction of copper ions with a MI-dPG coating to introduce Cu NPs into the coating matrix. This coating has been demonstrated to possess efficient long-term antibacterial properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and kanamycin-resistant E. coli through an "attract-kill-release" strategy. The synergistic antibacterial activity of the coating was shown by the combination of two functions of the contact killing, reactive oxygen species production and Cu ions released from the coating. Furthermore, this coating inhibited biofilm formation and showed good compatibility to eukaryotic cells. Thus, this newly developed Cu NP-incorporated MI-dPG surface coating may find potential application in the design of antimicrobialA novel surface coating with durable broad-spectrum antibacterial ability was prepared based on mussel inspired dendritic polyglycerol (MI-dPG) embedded with copper nanoparticles (Cu NPs). The functional surface coating is fabricated via a facile dip-coating process followed by in situ reduction of copper ions with a MI-dPG coating to introduce Cu NPs into the coating matrix. This coating has been demonstrated to possess efficient long-term antibacterial properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and kanamycin-resistant E. coli through an "attract-kill-release" strategy. The synergistic antibacterial activity of the coating was shown by the combination of two functions of the contact killing, reactive oxygen species production and Cu ions released from the coating. Furthermore, this coating inhibited biofilm formation and showed good compatibility to eukaryotic cells. Thus, this newly developed Cu NP-incorporated MI-dPG surface coating may find potential application in the design of antimicrobial coating, such as implantable devices.…
MetadatenAuthor details: | Mingjun Li, Lingyan Gao, Christoph Schlaich, Jianguang Zhang, Ievgen S. Donskyi, Guozhi Yu, Wenzhong Li, Zhaoxu Tu, Jens Rolff, Tanja SchwerdtleORCiDGND, Rainer HaagORCiDGND, Nan Ma |
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DOI: | https://doi.org/10.1021/acsami.7b10541 |
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ISSN: | 1944-8244 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/28914053 |
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Title of parent work (English): | ACS applied materials & interfaces |
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Publisher: | American Chemical Society |
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Place of publishing: | Washington |
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Publication type: | Article |
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Language: | English |
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Year of first publication: | 2017 |
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Publication year: | 2017 |
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Release date: | 2020/04/20 |
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Tag: | Cu NP-incorporated MI-dPG coating; antibacterial effect; drug-resistant bacteria; in situ chemical reduction; universal coating |
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Volume: | 9 |
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Number of pages: | 8 |
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First page: | 35411 |
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Last Page: | 35418 |
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Funding institution: | China Scholarship Council; DRS-POINT |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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Peer review: | Referiert |
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