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Long-term effect of a low-intensity smoking intervention embedded in an adherence program for patients with hypercholesterolemia: Randomized controlled trial

  • Objective. We evaluated the long-term effect of a smoking intervention embedded in an adherence program in patients with an increased risk for cardiovascular disease. Method. Secondary analysis of a randomized controlled trial: In 2002-2004,8108 patients with hypercholesterolemia were enrolled from general practices in Germany. Patients received a 12-month adherence program and statin medication (intervention) or statin medication only (control). The program aimed to improve adherence to medication and lifestyle by educational material, mailings, and phone calls. Smoking was self-reported at baseline and every 6 months during the 3-year follow-up. Results. In total, 7640 patients were analyzed. At baseline, smoking prevalence was 21.7% in the intervention and 21.5% in the control group. Prevalence decreased in both groups to 16.6% vs. 19.5%, 153% vs. 16.8%, and 14.2% vs. 15.6% at the 12-, 24-, and 36-month follow-up. The intervention had a beneficial effect on smoking differing over time (group x time: P = 0.005). The effect wasObjective. We evaluated the long-term effect of a smoking intervention embedded in an adherence program in patients with an increased risk for cardiovascular disease. Method. Secondary analysis of a randomized controlled trial: In 2002-2004,8108 patients with hypercholesterolemia were enrolled from general practices in Germany. Patients received a 12-month adherence program and statin medication (intervention) or statin medication only (control). The program aimed to improve adherence to medication and lifestyle by educational material, mailings, and phone calls. Smoking was self-reported at baseline and every 6 months during the 3-year follow-up. Results. In total, 7640 patients were analyzed. At baseline, smoking prevalence was 21.7% in the intervention and 21.5% in the control group. Prevalence decreased in both groups to 16.6% vs. 19.5%, 153% vs. 16.8%, and 14.2% vs. 15.6% at the 12-, 24-, and 36-month follow-up. The intervention had a beneficial effect on smoking differing over time (group x time: P = 0.005). The effect was largest after 6 and 12 months [odds ratios (95% confidence intervals): 0.67 (0.54-0.82) and 0.63 (0.51-0.78)]. The effect decreased until the 18-month follow-up [0.72 (0.58-0.90)] and was not significant after 24 months. Conclusion. A low-intensity smoking intervention embedded in an adherence program can contribute to smoking cessation although the intervention effect diminished over time. (C) 2015 Elsevier Inc. All rights reserved.show moreshow less

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Author details:Rebecca Muckelbauer, Heike Englert, Nina RieckmannORCiDGND, Chih-Mei Chen, Karl WegscheiderORCiDGND, Heinz VöllerORCiDGND, Hugo A. Katus, Stefan N. Willich, Jacqueline Müller-Nordhorn
DOI:https://doi.org/10.1016/j.ypmed.2015.05.026
ISSN:0091-7435
ISSN:1096-0260
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/26051201
Title of parent work (English):Preventive medicine : an international journal devoted to practice and theory
Publisher:Elsevier
Place of publishing:San Diego
Publication type:Article
Language:English
Year of first publication:2015
Publication year:2015
Release date:2017/03/27
Tag:Cardiovascular risk factors; Health promotion; Hypercholesterolemia; Multiple risk factor intervention; Randomized controlled trial; Smoking; Smoking cessation
Volume:77
Number of pages:7
First page:155
Last Page:161
Funding institution:Berlin School of Public Health, Charite - Universitatsmedizin Berlin; AstraZeneca
Organizational units:Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften
Peer review:Referiert
Institution name at the time of the publication:Humanwissenschaftliche Fakultät / Exzellenzbereich Kognitionswissenschaften
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