Unprecedented, low cytotoxicity of spongelike calcium phosphate/poly(ethylene imine) hydrogel composites
- Covalently crosslinked PEI hydrogels are efficient templates for calcium phosphate mineralization in SBF. In contrast to the PEI hydrogels, non-crosslinked PEI does not lead to calcium phosphate nucleation and growth in SBF. The precipitate is a mixture of brushite and hydroxyapatite. The PEI/calcium phosphate composite material exhibits a sponge like morphology and a chemical composition that is interesting for implants. Cytotoxicity tests using Dictyostelium discoideum amoebae show that both the non-mineralized and mineralized hydrogels have a very low cytotoxicity. This suggests that next generation PEI hydrogels, where also the degradation products are non-toxic, could be interesting for biomedical applications.
| Verfasserangaben: | Andriy Shkilnyy, Ralph GräfORCiDGND, Bernhard Hiebl, Axel T. NeffeORCiDGND, Alwin Friedrich, Juergen Hartmann, Andreas TaubertORCiDGND |
|---|---|
| URL: | http://www3.interscience.wiley.com/cgi-bin/jhome/77002860 |
| DOI: | https://doi.org/10.1002/mabi.200800266 |
| ISSN: | 1616-5187 |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2009 |
| Erscheinungsjahr: | 2009 |
| Datum der Freischaltung: | 25.03.2017 |
| Quelle: | Macromolecular bioscience. - ISSN 1616-5187. - 9 (2009), 2, S. 179 - 186 |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer Review: | Referiert |
