Polymer Brush Controlled Bioinspired Calcium Phosphate Mineralization and Bone Cell Growth
- Polymer brushes on thiol-modified gold surfaces were synthesized by using terminal thiol groups for the surface initiated free radical polymerization of methacrylic acid and dimethylaminotheyl methacrylate, respectively. Atomic force microscopy shows that the resulting poly(methacrylic acid (PMAA) and poly(dimethylaminothyl methacrylate) (PDM- AEMA) brushes are homogeneous. Contact angle measurements show that the brushes are pH responsive and can reversibly be protonated and deprotonated. Mineralization of the brushes with calcium phosphate at different pH yields homogeneously mineralized surfaces, and preosteoblastic cells proliferate-on be number of living cells on the mineralized hybrid surface is ca. 3 times (P corresponding nonmineralized brushes.
| Verfasserangaben: | Ruben Löbbicke, Munish ChananaGND, Helmut SchlaadORCiDGND, Christine Pilz-Allen, Christina GünterGND, Helmuth MöhwaldGND, Andreas TaubertORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1021/bm200991b |
| ISSN: | 1525-7797 |
| Titel des übergeordneten Werks (Englisch): | Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences |
| Verlag: | American Chemical Society |
| Verlagsort: | Washington |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2011 |
| Erscheinungsjahr: | 2011 |
| Datum der Freischaltung: | 26.03.2017 |
| Band: | 12 |
| Ausgabe: | 10 |
| Seitenanzahl: | 8 |
| Erste Seite: | 3753 |
| Letzte Seite: | 3760 |
| Fördernde Institution: | Max Planck Institute of Colloids Interfaces; University of Potsdam |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer Review: | Referiert |
