Tobias Mai, Ekaterina Rakhmatullina, Katrin Bleek, Susanne Boye, Jiayin Yuan, Antje Voelkel, Marlies Graewert, Zeinab Cheaib, Sigrun Eick, Christina Günter, Albena Lederer, Adrian Lussi, Andreas Taubert
- Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests thatPoly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.…
MetadatenAuthor details: | Tobias Mai, Ekaterina Rakhmatullina, Katrin BleekORCiDGND, Susanne Boye, Jiayin YuanORCiDGND, Antje Voelkel, Marlies Graewert, Zeinab Cheaib, Sigrun Eick, Christina GünterGND, Albena Lederer, Adrian Lussi, Andreas TaubertORCiDGND |
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DOI: | https://doi.org/10.1021/bm500888q |
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ISSN: | 1525-7797 |
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ISSN: | 1526-4602 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25230392 |
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Title of parent work (English): | Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences |
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Publisher: | American Chemical Society |
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Place of publishing: | Washington |
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Publication type: | Article |
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Language: | English |
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Year of first publication: | 2014 |
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Publication year: | 2014 |
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Release date: | 2017/03/27 |
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Volume: | 15 |
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Issue: | 11 |
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Number of pages: | 14 |
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First page: | 3901 |
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Last Page: | 3914 |
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Funding institution: | University of Bern; Max Planck Institute of Colloids and Interfaces;
University of Potsdam |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
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Peer review: | Referiert |
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