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Polymer looping is controlled by macromolecular crowding, spatial confinement, and chain stiffness

  • We study by extensive computer simulations the looping characteristics of linear polymers with varying persistence length inside a spherical cavity in the presence of macromolecular crowding. For stiff chains, the looping probability and looping time reveal wildly oscillating patterns as functions of the chain length. The effects of crowding differ dramatically for flexible versus stiff polymers. While for flexible chains the looping kinetics is slowed down by the crowders, for stiffer chains the kinetics turns out to be either decreased or facilitated, depending on the polymer length. For severe confinement, the looping kinetics may become strongly facilitated by crowding. Our findings are of broad impact for DNA looping in the crowded and compartmentalized interior of living biological cells.

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Metadaten
Author details:Jaeoh Shin, Andrey G. CherstvyORCiD, Ralf MetzlerORCiDGND
DOI:https://doi.org/10.1021/mz500709w
ISSN:2161-1653
Title of parent work (English):ACS Macro Letters
Publisher:American Chemical Society
Place of publishing:Washington
Publication type:Article
Language:English
Year of first publication:2015
Publication year:2015
Release date:2017/03/27
Volume:4
Issue:2
Number of pages:5
First page:202
Last Page:206
Funding institution:Academy of Finland; Deutsche Forschungsgemeinschaft (DFG) [CH 707/5-1]; German Federal Ministry of Education and Research (BMBF Project)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie
Peer review:Referiert
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