The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria
- The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP. As a starting point, the discovery of molybdopterin and the elucidation of its structure through the study of stable degradation products are described. Subsequent to molybdopterin synthesis, the molybdenum atom is added to the molybdopterin dithiolene group to form the molybdenum cofactor. This cofactor is either inserted directly into specific molybdoenzymes or is further modified by the addition of nucleotides to molybdopterin phosphate group or the replacement of ligands at the molybdenum center.
Author details: | Silke LeimkühlerORCiDGND, Margot M. Wuebbens, K. V. Rajagopalan |
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DOI: | https://doi.org/10.1016/j.ccr.2010.12.003 |
ISSN: | 0010-8545 |
Title of parent work (English): | Coordination chemistry reviews |
Publisher: | Elsevier |
Place of publishing: | Lausanne |
Publication type: | Review |
Language: | English |
Year of first publication: | 2011 |
Publication year: | 2011 |
Release date: | 2017/03/26 |
Tag: | Dithiolene group; Molybdenum cofactor; Molybdopterin; Molybdopterin guanine dinucleotide cofactor; Precursor Z; Urothione |
Volume: | 255 |
Issue: | 9-10 |
Number of pages: | 16 |
First page: | 1129 |
Last Page: | 1144 |
Funding institution: | Deutsche Forschungsgemeinschaft; NIH |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |