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Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea

  • The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.

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Author:Wanyama P. Juma, Hoseah M. Akala, Fredrick L. Eyase, Lois M. Muiva, Matthias HeydenreichORCiD, Faith A. Okalebo, Peter M. Gitu, Martin G. Peter, Douglas S. Walsh, Mabel Imbuga, Abiy Yenesew
ISSN:1874-3900 (print)
Parent Title (English):Phytochemistry letters
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Antiplasmodial; Flavone; Leguminosae; Stem; Tephrosia purpurea; Terpurinflavone
First Page:176
Last Page:178
Funder:Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry for Economic Cooperation and Development (BMZ) within the DFG/BMZ
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert