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Antiplasmodial flavonoids from Erythrina sacleuxii

  • The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence

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Author:Andrew W. Andayi, Abiy Yenesew, Solomon DereseORCiD, Jacob O. Midiwo, Peter M. Gitu, Ogoche J. I. Jondiko, Hoseah M. Akala, Pamela Liyala, Julia Wangui, Norman C. Waters, Matthias HeydenreichORCiD, Martin G. Peter
URL:http://www.thieme-connect.com/ejournals/toc/plantamedica
DOI:https://doi.org/10.1055/s-2005-873200
ISSN:0032-0943
Document Type:Article
Language:English
Year of first Publication:2006
Year of Completion:2006
Release Date:2017/03/25
Source:Planta medica. - ISSN 0032-0943. - 72 (2006), 2, S. 187 - 189
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert