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Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea
- The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.
| Author details: | Wanyama P. Juma, Hoseah M. AkalaORCiD, Fredrick L. Eyase, Lois M. Muiva, Matthias HeydenreichORCiD, Faith A. Okalebo, Peter M. Gitu, Martin G. Peter, Douglas S. Walsh, Mabel Imbuga, Abiy YenesewORCiD |
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| DOI: | https://doi.org/10.1016/j.phytol.2011.02.010 |
| ISSN: | 1874-3900 |
| Title of parent work (English): | Phytochemistry letters |
| Publisher: | Elsevier |
| Place of publishing: | Amsterdam |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2011 |
| Publication year: | 2011 |
| Release date: | 2017/03/26 |
| Tag: | Antiplasmodial; Flavone; Leguminosae; Stem; Tephrosia purpurea; Terpurinflavone |
| Volume: | 4 |
| Issue: | 2 |
| Number of pages: | 3 |
| First page: | 176 |
| Last Page: | 178 |
| Funding institution: | Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry for Economic Cooperation and Development (BMZ) within the DFG/BMZ |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
