Giacomo Potente, Étienne Léveillé-Bourret, Narjes Yousefi, Rimjhim Roy Choudhury, Barbara Keller, Seydina Issa Diop, Daniël Duijsings, Walter Pirovano, Michael Lenhard, Péter Szövényi, Elena Conti
- Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity viaSupergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula?…
MetadatenAuthor details: | Giacomo PotenteORCiD, Étienne Léveillé-BourretORCiD, Narjes Yousefi, Rimjhim Roy ChoudhuryORCiD, Barbara KellerORCiD, Seydina Issa Diop, Daniël DuijsingsORCiD, Walter PirovanoORCiD, Michael LenhardORCiDGND, Péter SzövényiORCiD, Elena ContiORCiD |
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DOI: | https://doi.org/10.1093/molbev/msac035 |
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ISSN: | 0737-4038 |
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ISSN: | 1537-1719 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35143659 |
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Title of parent work (English): | Molecular biology and evolution : MBE |
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Publisher: | Oxford Univ. Press |
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Place of publishing: | Oxford |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/02/03 |
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Publication year: | 2022 |
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Release date: | 2024/04/25 |
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Tag: | chromosome-scale genome assembly; evolutionary genomics; genome architecture; heterostyly; primula; supergene |
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Volume: | 39 |
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Issue: | 2 |
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Article number: | msac035 |
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Number of pages: | 16 |
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Funding institution: | European Union's Horizon 2020 research and innovation program-Marie; Skodowska-Curie [722338-PlantHUB]; Swiss National Science Foundation; [31003A_175556/1, 160004, 131726, 184826]; Deutsche; Forschungsgemeinschaft (German Research Foundation) [SPP 2237,; 440370263, HI 2076/1-1]; Georges and Antoine Claraz Foundation;; Forschungskredit; University Research Priority Program "Evolution in; Action" of the University of Zurich |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
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DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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Peer review: | Referiert |
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Publishing method: | Open Access / Gold Open-Access |
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| DOAJ gelistet |
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License (German): | CC-BY-NC - Namensnennung, nicht kommerziell 4.0 International |
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