Vitamin D and cardiovascular risk in postmenopausal women how to translate preclinical evidence into benefit for patients
- Preclinical work indicates that calcitriol restores vascular function by normalizing the endothelial expression of cyclooxygenase-2 and thromboxane-prostanoid receptors in conditions of estrogen deficiency and thus prevents the thromboxane-prostanoid receptor activation-induced inhibition of nitric oxide synthase. Since endothelial dysfunction is a key factor in the pathogenesis of cardiovascular diseases, this finding may have an important translational impact. It provides a clear rationale to use endothelial function in clinical trials aiming to find the optimal dose of vitamin D for the prevention of cardiovascular events in postmenopausal women.
Author details: | Berthold HocherORCiDGND, Christoph ReichetzederORCiDGND |
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DOI: | https://doi.org/10.1038/ki.2013.139 |
ISSN: | 0085-2538 |
Title of parent work (English): | Kidney international : official journal of the International Society of Nephrology |
Publisher: | Nature Publ. Group |
Place of publishing: | New York |
Publication type: | Preprint |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Volume: | 84 |
Issue: | 1 |
Number of pages: | 3 |
First page: | 9 |
Last Page: | 11 |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
Peer review: | Referiert |