Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix

Polymer multicomponent coatings such as multilayers mimic an extracellular, matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermeable barrier that governs molecular transport into/from the multilayers, and makes them biodegradation-resistant. Model protein lysozyme (mimics of ECM-soluble signals) diffuses into the multilayers as fast- and, slow-diffusing populations existing in an equilibrium,. Such a. composite system may have high potential to be exploited as degradation-resistant drug-delivery platforms suitable for cell-based applications.

Metadaten
Verfasserangaben:	Vladimir Z. Prokopovic, Anna S. Vikulina, David Sustr, Claus Duschl ORCiD, Dmitry Volodkin
DOI:	https://doi.org/10.1021/acsami.6b10095
ISSN:	1944-8244
Pubmed ID:	https://pubmed.ncbi.nlm.nih.gov/27607839
Titel des übergeordneten Werks (Englisch):	Journal of colloid and interface science
Verlag:	American Chemical Society
Verlagsort:	Washington
Publikationstyp:	Wissenschaftlicher Artikel
Sprache:	Englisch
Jahr der Erstveröffentlichung:	2016
Erscheinungsjahr:	2016
Datum der Freischaltung:	22.03.2020
Freies Schlagwort / Tag:	cell adhesion; diffusion; enzymatic degradation; fluorescence recovery after photobleaching; hyaluronic acid; layer-by-layer; polylysine; semipermeable
Band:	8
Seitenanzahl:	5
Erste Seite:	24345
Letzte Seite:	24349
Fördernde Institution:	Alexander von Humboldt Foundation; DFG [VO 1716/2-3]
Organisationseinheiten:	Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:	Referiert