Reproducibility of novel immune-inflammatory biomarkers over 4 months
- Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.
| Author details: | Matthew Schenk, Fabian EichelmannORCiDGND, Matthias Bernd SchulzeORCiDGND, Natalia RudovichORCiDGND, Andreas F. H. PfeifferORCiDGND, Romina di GiuseppeORCiD, Heiner BöingGND, Krasimira AleksandrovaORCiDGND |
|---|---|
| DOI: | https://doi.org/10.2217/bmm-2018-0351 |
| ISSN: | 1752-0363 |
| ISSN: | 1752-0371 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31157547 |
| Title of parent work (English): | Biomarkers in medicine |
| Subtitle (English): | an analysis with repeated measures design |
| Publisher: | Future Medicine |
| Place of publishing: | London |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2019/06/03 |
| Publication year: | 2019 |
| Release date: | 2021/01/26 |
| Tag: | MMF; TGF-beta; clusterin; immune-inflammatory biomarkers; repeated measures design; reproducibility; suPAR |
| Volume: | 13 |
| Issue: | 8 |
| Number of pages: | 10 |
| First page: | 639 |
| Last Page: | 648 |
| Funding institution: | German Institute of Human Nutrition Potsdam-Rehbrucke |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| Peer review: | Referiert |
