Stress and Alterations in the Pain Matrix

  • The genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reductionThe genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reduction as exemplary therapies), their interaction, and the dose-response will be discussed in more detail, which might pave the way to a better understanding of alterations in the pain matrix and help to develop future prevention and therapeutic conceptsshow moreshow less

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Metadaten
Author details:Pia-Maria WippertORCiDGND, Christine WiebkingORCiDGND
DOI:https://doi.org/10.3390/ijerph15040785
ISSN:1660-4601
ISSN:1661-7827
Title of parent work (English):International Journal of Environmental Research and Public Health
Subtitle (English):A Biopsychosocial Perspective on Back Pain and Its Prevention and Treatment
Publisher:MDPI AG
Place of publishing:Basel
Publication type:Article
Language:English
Date of first publication:2018/04/18
Completion year:2018
Release date:2018/06/15
Tag:allostatic load; back pain; chronic pain; exercise; neuroplasticity; pain matrix; physical activity; relaxation; stress
Volume:15
Issue:4
First page:1
Last Page:11
Funding institution:Universität Potsdam, Publikationsfonds
Funding number:PA 2018_17
Organizational units:Humanwissenschaftliche Fakultät
DDC classification:6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
6 Technik, Medizin, angewandte Wissenschaften / 69 Hausbau, Bauhandwerk / 690 Hausbau, Bauhandwerk
Peer review:Referiert
Grantor:Publikationsfonds der Universität Potsdam
Publishing method:Open Access
License (German):License LogoCreative Commons - Namensnennung, 4.0 International
External remark:Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 438