Inhibition of farnesoic acid methyltransferase by sinefungin

  • Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.

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Author:Hans-Jürgen Ferenz, Martin G. Peter, Dieter Berg
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 077)
Document Type:Postprint
Year of Completion:1983
Publishing Institution:Universität Potsdam
Release Date:2008/09/17
Tag:Biological activity; Biosynthesis; Corpora allata; Enzyme; Enzyme inhibitor; In vitro; Juvenile hormone; Juvenile hormone analogue; Orthoptera
Source:Agricultural and Biological Chemistry. - 50 (1986), 4, pp.1003-1008. - ISSN (online) 1881-1280, ISSN (print) 0002-1369
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:
first published in:
Agricultural and Biological Chemistry. - 50 (1986), 4, pp. 1003-1008
ISSN (online) 1881-1280
ISSN (print) 0002-1369
Japan Society for Bioscience, Biotechnology and Agrochemistry