The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts

  • The antibiotic fungal metabolite sinefungin is a potent inhibitor of S-adenosylmethionine-acceptor methyltransferases. Its effect on insect metabolism and especially on corpora allata farnesoic acid methyltransferase, which catalyzes the penultimate step of juvenile hormone biosynthesis, was investigated in Locusta migratoria. Injection of sinefungin results in a delay of imaginal molt and in suppression of ovary development. Isolated corpora allata are unable to synthesize juvenile hormone III in the presence of more than 1.0 mM sinefungin. In a cell-free system containing the S-adenosylmethionine-dependent farnesoic acid methyltransferase from corpora allata sinefungin is a competitive inhibitor of the synthesis of methylfarnesoate with Ki of 1 μM.

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Author:Hans-Jörg Ferenz, Martin G. Peter
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 076)
Document Type:Postprint
Year of Completion:1987
Publishing Institution:Universität Potsdam
Release Date:2008/09/17
Tag:Locust; O-methyltransferase; juvenile hormone biosynthesis; sinefungin
Source:Insect Biochemistry. - 17 (1987), 7, pp. 1119-1122. - ISSN 0020-1790
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:
first published in:
Insect Biochemistry. - 17 (1987), 7, pp. 1119-1122
ISSN 0020-1790
DOI 10.1016/0020-1790(87)90132-6