Increase of urate formation by stimulation of sympathetic hepatic nerves, circulating noradrenaline and glucagon inthe perfused rat liver

  • In the isolated rat liver perfused in situ stimulation of the nerve bundles around the portal vein and the hepatic artery caused an increase of urate formation that was inhibited by the α1-blocker prazosine and the xanthine oxidase inhibitor allopurinol. Moreover, nerve stimulation increased glucose and lactate output and decreased perfusion flow. Infusion of noradrenaline had similar effects. Compared to nerve stimulation infusion of glucagon led to a less pronounced increase of urate formation and a twice as large increase in glucose output but a decrease in lactate release without affecting the flow rate. Insulin had no effect on any of the parameters studied.

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Author:Gerhard P. Püschel, Annegret Nath, Kurt Jungermann
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 038)
Document Type:Postprint
Date of Publication (online):2008/03/14
Year of Completion:1987
Publishing Institution:Universität Potsdam
Release Date:2008/03/14
Tag:Allantoin; Catecholamine; Glucagon; Hepatic nerve; Urate
Source:FEBS Letters 219 (1987), 1, p. 145 - 150 , DOI 10.1016/0014-5793(87)81207-3, ISSN 0014-5793
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
Extern / Extern
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:
first published in:
FEBS Letters - 219 (1987), 1, p. 145-150
ISSN: 0014-5793
doi: 10.1016/0014-5793(87)81207-3