TY - JOUR
A1 - Abdalla, H.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Armstrong, T.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Baghmanyan, V.
A1 - Martins, V. Barbosa
A1 - Barnacka, A.
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernlohr, K.
A1 - Bi, B.
A1 - Bottcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - de Lavergne, M. de Bony
A1 - Bordas, Pol
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buchele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Cotter, G.
A1 - Curylo, M.
A1 - Mbarubucyeye, J. Damascene
A1 - Davids, I. D.
A1 - Davies, J.
A1 - Deil, C.
A1 - Devin, J.
A1 - deWilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V.
A1 - Duffy, C.
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Eichhorn, F.
A1 - Einecke, S.
A1 - Emery, G.
A1 - Ernenwein, J. -P.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - de Clairfontaine, G. Fichet
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fussling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Giavitto, G.
A1 - Giunti, L.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M. -H.
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Hermann, G.
A1 - Hinton, J. A.
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, T. L.
A1 - Holler, M.
A1 - Horbe, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Joshi, V.
A1 - Jung-Richardt, I.
A1 - Kasai, E.
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu.
A1 - Konno, R.
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kreter, M.
A1 - Lamanna, G.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J. -P.
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I.
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Malyshev, D.
A1 - Marandon, V.
A1 - Marchegiani, P.
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Meyer, M.
A1 - Mitchell, A.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Montanari, A.
A1 - Moore, C.
A1 - Morris, P.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, K.
A1 - Nayerhoda, A.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - O'Brien, Patrick
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Olivera-Nieto, L.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I.
A1 - Panter, M.
A1 - Panny, S.
A1 - Parsons, R. D.
A1 - Peron, G.
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V.
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puhlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reichherzer, P.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V.
A1 - Sailer, S.
A1 - Sanchez, D. A.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Scalici, M.
A1 - Schussler, F.
A1 - Schutte, H. M.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spencer, S.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Sun, L.
A1 - Steenkamp, R.
A1 - Stegmann, C.
A1 - Steinmassl, S.
A1 - Steppa, C.
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Tomankova, L.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Volk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - Watson, J.
A1 - Werner, F.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Wong, Yu Wun
A1 - Yusafzai, A.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zargaryan, D.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Zhu, S. J.
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zouari, S.
A1 - Zywucka, N.
T1 - An extreme particle accelerator in the Galactic plane
BT - HESS J1826-130
JF - Astronomy and astrophysics : an international weekly journal
N2 - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW - ISM: supernova remnants
KW - ISM: clouds
KW - gamma rays: general
KW - gamma rays:
KW - ISM
Y1 - 2020
U6 - https://doi.org/10.1051/0004-6361/202038851
SN - 0004-6361
SN - 1432-0746
VL - 644
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Tardif-Becquet, Delphine
A1 - Fluteau, Frédéric
A1 - Donnadieu, Yannick
A1 - Le Hir, Guillaume
A1 - Ladant, Jean-Baptiste
A1 - Sepulchre, Pierre
A1 - Licht, Alexis
A1 - Poblete, Fernando
A1 - Dupont-Nivet, Guillaume
T1 - The origin of Asian monsoons
BT - a modelling perspective
JF - Climate of the Past
N2 - The Cenozoic inception and development of the Asian monsoons remain unclear and have generated much debate, as several hypotheses regarding circulation patterns at work in Asia during the Eocene have been proposed in the few last decades. These include (a) the existence of modern-like monsoons since the early Eocene; (b) that of a weak South Asian monsoon (SAM) and little to no East Asian monsoon (EAM); or (c) a prevalence of the Intertropical Convergence Zone (ITCZ) migrations, also referred to as Indonesian-Australian monsoon (I-AM). As SAM and EAM are supposed to have been triggered or enhanced primarily by Asian palaeogeographic changes, their possible inception in the very dynamic Eocene palaeogeographic context remains an open question, both in the modelling and field-based communities. We investigate here Eocene Asian climate conditions using the IPSL-CM5A2 (Sepulchre et al., 2019) earth system model and revised palaeogeographies. Our Eocene climate simulation yields atmospheric circulation patterns in Asia substantially different from modern conditions. A large high-pressure area is simulated over the Tethys ocean, which generates intense low tropospheric winds blowing southward along the western flank of the proto-Himalayan-Tibetan plateau (HTP) system. This low-level wind system blocks, to latitudes lower than 10 degrees N, the migration of humid and warm air masses coming from the Indian Ocean. This strongly contrasts with the modern SAM, during which equatorial air masses reach a latitude of 20-25 degrees N over India and southeastern China. Another specific feature of our Eocene simulation is the widespread subsidence taking place over northern India in the midtroposphere (around 5000 m), preventing deep convective updraught that would transport water vapour up to the condensation level. Both processes lead to the onset of a broad arid region located over northern India and over the HTP. More humid regions of high seasonality in precipitation encircle this arid area, due to the prevalence of the Intertropical Convergence Zone (ITCZ) migrations (or Indonesian-Australian monsoon, I-AM) rather than monsoons. Although the existence of this central arid region may partly result from the specifics of our simulation (model dependence and palaeogeographic uncertainties) and has yet to be confirmed by proxy records, most of the observational evidence for Eocene monsoons are located in the highly seasonal transition zone between the arid area and the more humid surroundings. We thus suggest that a zonal arid climate prevailed over Asia before the initiation of monsoons that most likely occurred following Eocene palaeogeographic changes. Our results also show that precipitation seasonality should be used with caution to infer the presence of a monsoonal circulation and that the collection of new data in this arid area is of paramount importance to allow the debate to move forward.
KW - earth system model
KW - early eocene
KW - tibetan plateau
KW - climate-change
KW - oligocene climate
KW - summer monsoon
KW - global monsoon
KW - ice sheet
KW - part 1
KW - China
Y1 - 2020
U6 - https://doi.org/10.5194/cp-16-847-2020
SN - 1814-9332
SN - 1814-9324
VL - 16
IS - 3
SP - 847
EP - 865
PB - Copernicus Publications
CY - Göttingen
ER -
TY - GEN
A1 - Tardif-Becquet, Delphine
A1 - Fluteau, Frédéric
A1 - Donnadieu, Yannick
A1 - Le Hir, Guillaume
A1 - Ladant, Jean-Baptiste
A1 - Sepulchre, Pierre
A1 - Licht, Alexis
A1 - Poblete, Fernando
A1 - Dupont-Nivet, Guillaume
T1 - The origin of Asian monsoons
BT - a modelling perspective
T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2 - The Cenozoic inception and development of the Asian monsoons remain unclear and have generated much debate, as several hypotheses regarding circulation patterns at work in Asia during the Eocene have been proposed in the few last decades. These include (a) the existence of modern-like monsoons since the early Eocene; (b) that of a weak South Asian monsoon (SAM) and little to no East Asian monsoon (EAM); or (c) a prevalence of the Intertropical Convergence Zone (ITCZ) migrations, also referred to as Indonesian-Australian monsoon (I-AM). As SAM and EAM are supposed to have been triggered or enhanced primarily by Asian palaeogeographic changes, their possible inception in the very dynamic Eocene palaeogeographic context remains an open question, both in the modelling and field-based communities. We investigate here Eocene Asian climate conditions using the IPSL-CM5A2 (Sepulchre et al., 2019) earth system model and revised palaeogeographies. Our Eocene climate simulation yields atmospheric circulation patterns in Asia substantially different from modern conditions. A large high-pressure area is simulated over the Tethys ocean, which generates intense low tropospheric winds blowing southward along the western flank of the proto-Himalayan-Tibetan plateau (HTP) system. This low-level wind system blocks, to latitudes lower than 10 degrees N, the migration of humid and warm air masses coming from the Indian Ocean. This strongly contrasts with the modern SAM, during which equatorial air masses reach a latitude of 20-25 degrees N over India and southeastern China. Another specific feature of our Eocene simulation is the widespread subsidence taking place over northern India in the midtroposphere (around 5000 m), preventing deep convective updraught that would transport water vapour up to the condensation level. Both processes lead to the onset of a broad arid region located over northern India and over the HTP. More humid regions of high seasonality in precipitation encircle this arid area, due to the prevalence of the Intertropical Convergence Zone (ITCZ) migrations (or Indonesian-Australian monsoon, I-AM) rather than monsoons. Although the existence of this central arid region may partly result from the specifics of our simulation (model dependence and palaeogeographic uncertainties) and has yet to be confirmed by proxy records, most of the observational evidence for Eocene monsoons are located in the highly seasonal transition zone between the arid area and the more humid surroundings. We thus suggest that a zonal arid climate prevailed over Asia before the initiation of monsoons that most likely occurred following Eocene palaeogeographic changes. Our results also show that precipitation seasonality should be used with caution to infer the presence of a monsoonal circulation and that the collection of new data in this arid area is of paramount importance to allow the debate to move forward.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1436
KW - earth system model
KW - early eocene
KW - tibetan plateau
KW - climate-change
KW - oligocene climate
KW - summer monsoon
KW - global monsoon
KW - ice sheet
KW - part 1
KW - China
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516770
SN - 1866-8372
IS - 1436
ER -
TY - THES
A1 - Meijer, Niels
T1 - Asian dust, monsoons and westerlies during the Eocene
N2 - The East Asian monsoons characterize the modern-day Asian climate, yet their geological history and driving mechanisms remain controversial. The southeasterly summer monsoon provides moisture, whereas the northwesterly winter monsoon sweeps up dust from the arid Asian interior to form the Chinese Loess Plateau. The onset of this loess accumulation, and therefore of the monsoons, was thought to be 8 million years ago (Ma). However, in recent years these loess records have been extended further back in time to the Eocene (56-34 Ma), a period characterized by significant changes in both the regional geography and global climate. Yet the extent to which these reconfigurations drive atmospheric circulation and whether the loess-like deposits are monsoonal remains debated. In this thesis, I study the terrestrial deposits of the Xining Basin previously identified as Eocene loess, to derive the paleoenvironmental evolution of the region and identify the geological processes that have shaped the Asian climate.
I review dust deposits in the geological record and conclude that these are commonly represented by a mix of both windblown and water-laid sediments, in contrast to the pure windblown material known as loess. Yet by using a combination of quartz surface morphologies, provenance characteristics and distinguishing grain-size distributions, windblown dust can be identified and quantified in a variety of settings. This has important implications for tracking aridification and dust-fluxes throughout the geological record.
Past reversals of Earth’s magnetic field are recorded in the deposits of the Xining Basin and I use these together with a dated volcanic ash layer to accurately constrain the age to the Eocene period. A combination of pollen assemblages, low dust abundances and other geochemical data indicates that the early Eocene was relatively humid suggesting an intensified summer monsoon due to the warmer greenhouse climate at this time. A subsequent shift from predominantly freshwater to salt lakes reflects a long-term aridification trend possibly driven by global cooling and the continuous uplift of the Tibetan Plateau. Superimposed on this aridification are wetter intervals reflected in more abundant lake deposits which correlate with highstands of the inland proto-Paratethys Sea. This sea covered the Eurasian continent and thereby provided additional moisture to the winter-time westerlies during the middle to late Eocene.
The long-term aridification culminated in an abrupt shift at 40 Ma reflected by the onset of windblown dust, an increase in steppe-desert pollen, the occurrence of high-latitude orbital cycles and northwesterly winds identified in deflated salt deposits. Together, these indicate the onset of a Siberian high atmospheric pressure system driving the East Asian winter monsoon as well as dust storms and was triggered by a major sea retreat from the Asian interior. These results therefore show that the proto-Paratethys Sea, though less well recognized than the Tibetan Plateau and global climate, has been a major driver in setting up the modern-day climate in Asia.
N2 - Die ostasiatischen Monsune prägen das heutige asiatische Klima, doch ihr geologischer Ursprung und ihre Antriebsmechanismen sind nach wie vor umstritten. Der südöstliche Sommermonsun bringt Feuchtigkeit, während der nordwestliche Wintermonsun Staub aus dem trockenen asiatischen Inland aufwirbelt und das chinesische
Lössplateau bildet. Der Ursprung dieses Lösses und damit des Monsuns wurde vor 8 Millionen Jahren vermutet (Ma). In den letzten Jahren sind diese Lößablagerungen jedoch weiter in das Eozän (56-34 Ma) zurückverlegt worden, einer Periode, die durch bedeutende Änderungen sowohl in der regionalen Geographie als auch
im globalen Klima gekennzeichnet ist. Inwieweit diese Rekonfigurationen die atmosphärische Zirkulation antrieben und ob es sich bei den lößartigen Sedimenten um monsunartige Ablagerungen handelt, bleibt jedoch umstritten. In dieser Dissertation untersuche ich die terrestrischen Ablagerungen des Xining-Beckens, die zuvor als Löss aus dem Eozän identifiziert wurden, um die paläo-umweltbedingte Entwicklung der Region abzuleiten und die geologischen Prozesse zu identifizieren, die das asiatische Klima geprägt haben.
Ich überprüfe die Staubablagerungen im geologischen Archiv und komme zu dem Schluss, dass diese durch eine Mischung aus windgetriebenen und wassergelagerten Sedimenten dargestellt werden, im Gegensatz zu dem rein windgetriebenen Material, das als Löß bekannt ist. Doch durch die Verwendung einer Kombination der oberflächenmorphologien von Quartz, Herkunftsmerkmalen und unterscheidenden Korngrößenverteilungen kann windgetriebener Staub in einer Vielzahl von Umgebungen identifiziert und quantifiziert werden. Dies hat wichtige Auswirkungen auf die Nachverfolgung der Aridifizierung und der Staubflüsse in dem gesamten geologischen
Archiv.
Frühere Umkehrungen des Erdmagnetfeldes werden in den Ablagerungen des Xining-Beckens aufgezeichnet und ich verwende diese zusammen mit einer datierten vulkanischen Ascheschicht, um das Alter genau auf die Eozän-Periode einzugrenzen. Eine Kombination aus Pollenansammlungen, geringen Staubhäufigkeiten und anderen geochemischen Daten deutet darauf hin, dass das frühe Eozän relativ feucht war, was auf einen verstärkten Sommermonsun aufgrund des wärmeren Treibhausklimas zu dieser Zeit hinweist. Eine anschließende Verschiebung von überwiegend Süßwasser zu Salzseen spiegelt einen langfristigen Aridifizierungstrend wider, der möglicherweise durch die globale Abkühlung und die kontinuierliche Hebung des Tibetischen Plateaus angetrieben wurde. Überlagert wird diese Aridifizierung von feuchteren Intervallen, die durch eine Zunahme in Seeablagerungen gekennzeichnet werden und mit den Hochständen des inländischen proto-Paratethys-Meeres korrelieren. Dieses Meer bedeckte den eurasischen Kontinent und versorgte dadurch die winterlichen Westwinde mit zusätzlicher Feuchtigkeit im mittleren bis späten Eozän.
T2 - Asiatischer Staub, Monsune und Westwind während
des Eozäns
KW - Paleoclimatology
KW - Asia
KW - Eocene
KW - Stratigraphy
KW - Asien
KW - Stratigrafie
KW - Monsoon
KW - Monsun
KW - Paläoklimatologie
KW - Eozän
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-488687
ER -
TY - CHAP
A1 - Steinberg, Georg
ED - Hirte, Markus
ED - Koch, Arnd
ED - Mezey, Barna
T1 - Karl Marx und die Strafrechtspraxis sozialistischer Staaten
T2 - Wendepunkte der Strafrechtsgeschichte
Y1 - 2020
SN - 978-3-8379-2998-0
SN - 978-3-8379-7703-5
U6 - https://doi.org/10.30820/9783837977035-183
SP - 183
EP - 198
PB - Psychosozial-Verlag
CY - Gießen
ER -
TY - THES
A1 - Kaya, Mustafa
T1 - Cretaceous-Paleogene evolution of the proto-Paratethys Sea in Central Asia
BT - mechanisms and paleoenvironmental impacts
BT - Mechanismen und paläoökologische Auswirkungen
N2 - Unlike today’s prevailing terrestrial features, the geologic past of Central Asia witnessed marine environments and conditions as well. A vast, shallow sea, known as proto-Paratethys, extended across Eurasia from the Mediterranean Tethys to the Tarim Basin in western China during Cretaceous to Paleogene times. This sea formed about 160 million years ago (during Jurassic times) when the waters of the Tethys Ocean flooded into Eurasia. It drastically retreated to the west and became isolated as the Paratethys during the Late Eocene-Oligocene (ca. 34 Ma).
Having well-constrained timing and paleogeography for the Cretaceous-Paleogene proto-Paratethys sea incursions in Central Asia is essential to properly understand and distinguish the controlling mechanisms and their link to Asian paleoenvironmental and paleoclimatic change. The Cretaceous-Paleogene tectonic evolution of the Pamir and Tibet and their far-field effects play a significant role on the sedimentological and structural evolution of the Central Asian basins and on the evolution of the proto-Paratethys sea fluctuations as well. Comparing the records of the sea incursions to the tectonic and eustatic events has paramount importance to reveal the controlling mechanisms behind the sea incursions. However, due to inaccuracies in the dating of rocks (mostly continental rocks and marine rocks with benthic microfossils providing low-resolution biostratigraphic constraints) and conflicting results, there has been no consensus on the timing of the sea incursions and interpretation of their records has been in question. Here, we present a new chronostratigraphic framework based on biostratigraphy and magnetostratigraphy as well as a detailed paleoenvironmental analysis for the Cretaceous and Paleogene proto-Paratethys Sea incursions in the Tajik and Tarim basins, in Central Asia. This enables us to identify the major drivers of marine fluctuations and their potential consequences on regional and global climate, particularly Asian aridification and the global carbon cycle perturbations such as the Paleocene-Eocene Thermal Maximum (PETM). To estimate the paleogeographic evolution of the proto-Paratethys Sea, the refined age constraints and detailed paleoenvironmental interpretations are combined with successive paleogeographic maps. Regional coastlines and depositional environments during the Cretaceous-Paleogene sea advances and retreats were drawn based on the results of this thesis and integrated with existing literature to generate new paleogeographic maps.
Before its final westward retreat in the Eocene, a total of six Cretaceous and Paleogene major sea incursions have been distinguished from the sedimentary records of the Tajik and Tarim basins in Central Asia. All have been studied and documented here.
We identify the presence of marine conditions already in the Early Cretaceous in the western Tajik Basin, followed by the Cenomanian (ca. 100 Ma) and Santonian (ca. 86 Ma) major marine incursions far into the eastern Tajik and Tarim basins separated by a Turonian-Coniacian (ca. 92-86 Ma) regression. Basin-wide tectonic subsidence analyses imply that the Early Cretaceous invasion of the sea into the Tajik Basin is related to increased Pamir tectonism (at ca. 130 – 90 Ma) in a retro-arc basin setting inferred to be linked to collision and subduction. This tectonic event mainly governed the Cenomanian (ca. 100 Ma) sea incursion in conjunction with a coeval global eustatic high resulting in the maximum geographic extent of the sea. The following Turonian-Coniacian (ca. 92-86 Ma) major regression, driven by eustasy, coincides with a sharp slowdown in tectonic subsidence related to a regime change in Pamir tectonism from compression to extension. The Santonian (ca. 86 Ma) major sea incursion was more likely controlled dominantly by eustasy as also evidenced by the coeval fluctuations in the west Siberian Basin. During the early Maastrichtian, the global Late Cretaceous cooling is inferred from the disappearance of mollusk-rich limestones and the dominance of bryozoan-rich and echinoderm-rich limestones in the Tajik Basin documenting the first evidence for the Late Cretaceous cooling event in Central Asia.
Following the last Cretaceous sea incursion, a major regional restriction event, marked by the exceptionally thick (≤ 400 m) shelf evaporites is assigned a Danian-Selandian age (ca. 63-59 Ma). This is followed by the largest recorded proto-Paratethys sea incursion with a transgression estimated as early Thanetian (ca. 59-57 Ma) and a regression within the Ypresian (ca. 53-52 Ma). The transgression of the next incursion is now constrained as early Lutetian (ca. 47-46 Ma), whereas its regression is constrained as late Lutetian (ca. 41 Ma) and is associated with a drastic increase in both tectonic subsidence and basin infilling. The age of the final and least pronounced sea incursion restricted to the westernmost margin of the Tarim Basin is assigned as Bartonian–Priabonian (ca. 39.7-36.7 Ma). We interpret the long-term westward retreat of the proto-Paratethys Sea starting at ca. 41 Ma to be associated with far-field tectonic effects of the Indo-Asia collision and Pamir/Tibetan plateau uplift. Short-term eustatic sea level transgressions are superimposed on this long-term regression and seem coeval with the transgression events in the other northern Peri-Tethyan sedimentary provinces for the 1st and 2nd Paleogene sea incursions. However, the last Paleogene sea incursion is interpreted as related to tectonism. The transgressive and regressive intervals of the proto-Paratethys Sea correlate well with the reported humid and arid phases, respectively in the Qaidam and Xining basins, thus demonstrating the role of the proto-Paratethys Sea as an important moisture source for the Asian interior and its regression as a contributor to Asian aridification.
We lastly study the mechanics, relative contribution and preservation efficiency of ancient epicontinental seas as carbon sinks with new and existing data, using organic rich (sapropel) deposits dated to the PETM from the extensive epicontinental proto-Paratethys and West Siberian seas. We estimate ca. 1390±230 Gt organic C burial, a substantial amount compared to previously estimated global total excess organic C burial (ca. 1700-2900 Gt) is focused in the proto-Paratethys and West Siberian seas alone. We also speculate that enhanced organic carbon burial later over much of the proto-Paratethys (and later Paratethys) basin (during the deposition of the Kuma Formation and Maikop series, repectively) may have majorly contributed to drawdown of atmospheric carbon dioxide before and during the EOT cooling and glaciation of Antarctica. For past periods with smaller epicontinental seas, the effectiveness of this negative carbon cycle feedback was arguably diminished, and the same likely applies to the present-day.
N2 - Im Gegensatz zu den heute vorherrschenden kontinentalen Bedingungen war die geologische Vergangenheit Zentralasiens auch Zeuge marin dominierter Phasen. Ein riesiges Schelfmeer, bekannt als Proto-Paratethys, erstreckte sich während der Kreidezeit bis zum Paläogen über Eurasien - von der Tethys im Mittelmeer bis zum Tarimbecken im Westen Chinas. Dieses Meer bildete sich vor etwa 160 Millionen Jahren während der Jurazeit, als das Wasser des Tethys-Ozeans nach Eurasien strömte. Es zog sich drastisch nach Westen zurück und wurde während des späten Eozän-Oligozäns (ca. 34 Ma) als Paratethys isoliert.
Eine gut eingegrenzte zeitliche Einordnung und Paläogeographische Charakterisierung für die kretazisch-paläogenen proto-Paratethys-Meerestransgressionen in Zentralasien ist unerlässlich, um die Kontrollmechanismen und ihre Verbindung mit den paläoökologischen und paläoklimatischen Veränderungen in Asien richtig zu verstehen und zu unterscheiden. Die kreidezeitlich-paläogene tektonische Entwicklung des Pamir und Tibets und ihre Fernfeldeffekte spielen eine bedeutende Rolle für die Entwicklung der zentralasiatischen Becken und der proto-paläozoischen Meeresschwankungen. Aufgrund von Ungenauigkeiten bei der Datierung der Gesteine und widersprüchlichen Ergebnissen gab es jedoch bislang keinen Konsens über den Zeitpunkt der Meerestransgressionen. Die Interpretation der dabei abgelagerten Sedimentfolgen wurde in Frage gestellt. Hier präsentieren wir eine neue, zeitliche Einordung auf Grundlage von Biostratigraphie und Magnetostratigraphie sowie eine detaillierte Paläoumweltanalyse für die Transgressionen des kreidezeitlichen und paläogenen proto-Paratethys-Meeres im tadschikischen und Tarimbecken in Zentralasien. Dies ermöglicht es uns, die wichtigsten Triebkräfte der marinen Fluktuationen und ihre möglichen Auswirkungen auf das regionale und globale Klima zu identifizieren - insbesondere die asiatische Aridifizierung und die Störungen des globalen Kohlenstoffkreislaufs etwa während des paläozän-eozänen thermischen Maximums (PETM).
Beckenweite tektonische Senkungsanalysen deuten darauf hin, dass die frühkretazische Transgressionsphase im Tadschikischen Becken mit einer Intensivierung der Kollisionstektonik im Pamir (zwischen ca. 130 und 90 Ma) und der damit verbundenen Bildung eines Retro-Arc-Beckens in Zusammenhang stehen. Die globale Abkühlung der Spätkreide wird aus dem Verschwinden von molluskenreichen Kalksteinen und der Dominanz von bryozoen- und echinodermenreichen Kalksteinen im Tadschikischen Becken abgeleitet. Dies liefert den ersten Nachweis für das Abkühlungsereignis der Spätkreide in Zentralasien.
Wir interpretieren die langfristige paläogene Regression des Proto-Paratethys-Meeres Richtung Westen ab ca. 41 Ma mit den tektonischen Fernfeldeffekten der indo-asiatischen Kollision und der Hebung des Pamir/Tibetischen Plateaus. Die transgressiven und regressiven Intervalle der proto-Paratethys-See korrelieren gut mit den bekannten feuchten und ariden Phasen im Qaidam- bzw. Xining-Becken, was die Rolle der proto-Paratethys-See als wichtige Feuchtigkeitsquelle für das asiatische Binnenland und ihren Rückzug als Mitverursacher der asiatischen Aridifizierung verdeutlicht.
Schließlich untersuchen wir die Wirkungsfaktoren, den relativen Beitrag und die Erhaltungseffizienz alter epikontinentaler Meere als Kohlenstoffsenken mit neuen und bestehenden Daten. Dabei verwenden wir organik-reiche Ablagerungen aus den ausgedehnten epikontinentalen Proto-Paratethys- und westsibirischen Meeren, die auf das PETM datiert sind. Wir schätzen eine Einlagerung von ca. 1390±230 Gt organischer Kohlenstoffverbindungen. Das stellt eine beachtliche Menge, verglichen mit der zuvor geschätzten globalen Gesamtmenge an überschüssiger organischer Kohlenstoffeinlagerung (ca. 1700-2900 Gt) dar, welche sich allein auf die Proto-Paratethys und die westsibirischen Meere konzentriert. Für vergangene und zukünftige Perioden mit kleineren epikontinentalen Meeren würde die Wirksamkeit dieser negativen Rückkopplung des Kohlenstoffkreislaufs wohl abnehmen.
T2 - Kreidezeit - Paläogene Entwicklung des Proto-Paratethys-Meeres in Zentralasien
KW - Geology
KW - Paleoclimatology
KW - Sedimentology
KW - Stratigraphy
KW - Paleogeography
KW - Geologie
KW - Paläoklimatologie
KW - Sedimentologie
KW - Stratigraphie
KW - Paläogeographie
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-483295
ER -
TY - JOUR
A1 - Steinberg, Georg
T1 - Rezension zu: Krischer, André: Die Macht des Verfahrens : englische Hochverratsprozesse 1554–1848. - Münster : Aschendorff Verlag, 2017. - VII, 720 S. - ISBN: 978-3-402-14659-0. - (Verhandeln Verfahren Entscheiden – Historische Perspektiven ; 3)
JF - Zeitschrift der Savigny-Stiftung für Rechtsgeschichte : Germanistische Abteilung
Y1 - 2020
U6 - https://doi.org/10.1515/zrgg-2020-0051
SN - 0323-4045
SN - 2304-4861
VL - 137
IS - 1
SP - 609
EP - 611
PB - De Gruyter
CY - Berlin
ER -
TY - JOUR
A1 - Steinberg, Georg
T1 - Rezension zu: Thomasius, Christian: Briefwechsel. Band 1: 1679–1692 / Hrsg.: Frank Grunert, Matthias Hambrock, Martin Kühnel unter Mitarbeit von Andrea Thiele. - Berlin: de Gruyter, XLIV, 531 S.- ISBN 978-3-11-047002-4
JF - Zeitschrift der Savigny-Stiftung für Rechtsgeschichte : Germanistische Abteilung
Y1 - 2020
U6 - https://doi.org/10.1515/zrgg-2020-0033
SN - 0323-4045
SN - 2304-4861
VL - 137
IS - 1
SP - 559
EP - 561
PB - De Gruyter
CY - Berlin
ER -
TY - BOOK
ED - Steinberg, Georg
ED - Koch, Arnd
ED - Popp, Andreas
T1 - Strafrecht in der alten Bundesrepublik 1949-1990
BT - Grundlagen, Allgemeiner Teil und Rechtsfolgenseite im zeitgeschichtlichen Spiegel von Gesellschaft und Politik
T3 - Grundlagen des Strafrechts ; Band 8
N2 - Während bisher zur Geschichte des Strafrechts in der alten Bundesrepublik lediglich kürzere, überblicksartige Gesamtdarstellungen existierten, nimmt dieser Band das gesamte Spektrum des Allgemeinen Teils, flankiert durch die „Grundlagen“ und die Rechtsfolgenseite, detailreich in den Blick. Dabei werden die einzelnen Dogmengeschichten nicht isoliert dargestellt, sondern in ihrer Interaktion mit der Strafrechtswissenschaft, -praxis, -politik und gesellschaftlichen Veränderungen. Durchaus experimentell, werten die Beiträge teils Schrifttum, teils Judikatur als Quellen aus, teils schreiten sie Themenkreise aus, teils greifen sie aussagekräftige Einzelaspekte heraus, teils diskutieren sie zurückhaltend, teils intensiv sozialhistorische Korrelate.
N2 - Until now, the criminal law of the "alte Bundesrepublik" (Western Germany from 1949 to 1990) has been object of historical overviews. This book takes a more intense look into the historical developments of the different fields of criminal law dogmatics at the time. It aims to reveal historical interactions between these developments and those of politics and practice of criminal law.
Y1 - 2020
SN - 978-3-8487-7027-4
SN - 978-3-7089-2068-9
SN - 978-3-03891-287-3
U6 - https://doi.org/10.5771/9783748910862
PB - Nomos
CY - Baden-Baden
ER -
TY - JOUR
A1 - Steinberg, Georg
T1 - Lässt sich "Leichtfertigkeit" als Straftatbestandsmerkmal sinnvoll handhaben?
JF - Zeitschrift für die gesamte Strafrechtswissenschaft
Y1 - 2020
U6 - https://doi.org/10.1515/zstw-2019-0032
SN - 0084-5310
SN - 1612-703X
VL - 131
IS - 4
SP - 888
EP - 966
PB - De Gruyter
CY - Berlin
ER -
TY - JOUR
A1 - Steinberg, Georg
T1 - Das Jugendstrafrecht der DDR in ihrem letzten Jahrzehnt
JF - Zeitschrift für die gesamte Strafrechtswissenschaft
Y1 - 2020
U6 - https://doi.org/10.1515/zstw-2020-0014
SN - 0084-5310
SN - 1612-703X
VL - 132
IS - 2
SP - 397
EP - 440
PB - De Gruyter
CY - Berlin
ER -
TY - JOUR
A1 - Steinberg, Georg
A1 - Stam, Fabian
T1 - Zur Zurechnungsdogmatik
BT - die Heroinspritzen-Entscheidung des BGH von 1984 als „Wendepunkt“ der Rechtsprechung zur freiwilligen Selbstgefährdung?
JF - Strafrecht in der alten Bundesrepublik 1949-1990 : Grundlagen, Allgemeiner Teil und Rechtsfolgenseite im zeitgeschichtlichen Spiegel von Gesellschaft und Politik
Y1 - 2020
SN - 978-3-8487-7027-4
SN - 978-3-7089-2068-9
SN - 978-3-03891-287-3
U6 - https://doi.org/10.5771/9783748910862-263
SP - 263
EP - 294
PB - Nomos
CY - Baden-Baden
ER -
TY - JOUR
A1 - Koch, Arnd
A1 - Popp, Andreas
A1 - Steinberg, Georg
T1 - Vorwort
BT - Strafrecht in der alten Bundesrepublik als Gegenstand zeitgeschichtlicher Forschung
JF - Strafrecht in der alten Bundesrepublik 1949-1990: Grundlagen, Allgemeiner Teil und Rechtsfolgenseite im zeitgeschichtlichen Spiegel von Gesellschaft und Politik
Y1 - 2020
SN - 978-3-8487-7027-4
SN - 978-3-7089-2068-9
SN - 978-3-03891-287-3
U6 - https://doi.org/9783748910862-1
SP - 5
EP - 8
PB - Nomos
CY - Baden-Baden
ER -
TY - GEN
A1 - Lewkowicz, Daniel
A1 - Wohlbrandt, Attila
A1 - Böttinger, Erwin
T1 - Economic impact of clinical decision support interventions based on electronic health records
T2 - Postprints der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2 - Background
Unnecessary healthcare utilization, non-adherence to current clinical guidelines, or insufficient personalized care are perpetual challenges and remain potential major cost-drivers for healthcare systems around the world. Implementing decision support systems into clinical care is promised to improve quality of care and thereby yield substantial effects on reducing healthcare expenditure. In this article, we evaluate the economic impact of clinical decision support (CDS) interventions based on electronic health records (EHR).
Methods
We searched for studies published after 2014 using MEDLINE, CENTRAL, WEB OF SCIENCE, EBSCO, and TUFTS CEA registry databases that encompass an economic evaluation or consider cost outcome measures of EHR based CDS interventions. Thereupon, we identified best practice application areas and categorized the investigated interventions according to an existing taxonomy of front-end CDS tools.
Results and discussion
Twenty-seven studies are investigated in this review. Of those, twenty-two studies indicate a reduction of healthcare expenditure after implementing an EHR based CDS system, especially towards prevalent application areas, such as unnecessary laboratory testing, duplicate order entry, efficient transfusion practice, or reduction of antibiotic prescriptions. On the contrary, order facilitators and undiscovered malfunctions revealed to be threats and could lead to new cost drivers in healthcare. While high upfront and maintenance costs of CDS systems are a worldwide implementation barrier, most studies do not consider implementation cost. Finally, four included economic evaluation studies report mixed monetary outcome results and thus highlight the importance of further high-quality economic evaluations for these CDS systems.
Conclusion
Current research studies lack consideration of comparative cost-outcome metrics as well as detailed cost components in their analyses. Nonetheless, the positive economic impact of EHR based CDS interventions is highly promising, especially with regard to reducing waste in healthcare.
T3 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 5
KW - Economic evaluation
KW - Electronic health record
KW - Clinical decision support
KW - Behavioral economics
Y1 - 2021
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-501376
IS - 5
ER -
TY - JOUR
A1 - Lewkowicz, Daniel
A1 - Wohlbrandt, Attila
A1 - Böttinger, Erwin
T1 - Economic impact of clinical decision support interventions based on electronic health records
JF - BMC Health Services Research
N2 - Background
Unnecessary healthcare utilization, non-adherence to current clinical guidelines, or insufficient personalized care are perpetual challenges and remain potential major cost-drivers for healthcare systems around the world. Implementing decision support systems into clinical care is promised to improve quality of care and thereby yield substantial effects on reducing healthcare expenditure. In this article, we evaluate the economic impact of clinical decision support (CDS) interventions based on electronic health records (EHR).
Methods
We searched for studies published after 2014 using MEDLINE, CENTRAL, WEB OF SCIENCE, EBSCO, and TUFTS CEA registry databases that encompass an economic evaluation or consider cost outcome measures of EHR based CDS interventions. Thereupon, we identified best practice application areas and categorized the investigated interventions according to an existing taxonomy of front-end CDS tools.
Results and discussion
Twenty-seven studies are investigated in this review. Of those, twenty-two studies indicate a reduction of healthcare expenditure after implementing an EHR based CDS system, especially towards prevalent application areas, such as unnecessary laboratory testing, duplicate order entry, efficient transfusion practice, or reduction of antibiotic prescriptions. On the contrary, order facilitators and undiscovered malfunctions revealed to be threats and could lead to new cost drivers in healthcare. While high upfront and maintenance costs of CDS systems are a worldwide implementation barrier, most studies do not consider implementation cost. Finally, four included economic evaluation studies report mixed monetary outcome results and thus highlight the importance of further high-quality economic evaluations for these CDS systems.
Conclusion
Current research studies lack consideration of comparative cost-outcome metrics as well as detailed cost components in their analyses. Nonetheless, the positive economic impact of EHR based CDS interventions is highly promising, especially with regard to reducing waste in healthcare.
KW - Economic evaluation
KW - Electronic health record
KW - Clinical decision support
KW - Behavioral economics
Y1 - 2020
U6 - https://doi.org/10.1186/s12913-020-05688-3
SN - 1472-6963
VL - 20
PB - BioMed Central
CY - London
ER -
TY - JOUR
A1 - Moreno-Romero, Jordi
A1 - Probst, Aline V.
A1 - Trindade, Inês
A1 - Kalyanikrishna,
A1 - Engelhorn, Julia
A1 - Farrona, Sara
T1 - Looking At the Past and Heading to the Future
BT - Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany
JF - Frontiers in Plant Science
N2 - In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how chromatin organization controls gene expression, development, and plant responses to the environment. New evidence showing how epigenetic states are set, perpetuated, and inherited were presented, and novel data related to the three-dimensional organization of chromatin within the nucleus were discussed. At the level of the nucleosome, its composition by different histone variants and their specialized histone deposition complexes were addressed as well as the mechanisms involved in histone post-translational modifications and their role in gene expression. The keynote lecture on plant DNA methylation by Julie Law (SALK Institute) and the tribute session to Lars Hennig, honoring the memory of one of the founders of the EWPC who contributed to promote the plant chromatin and epigenetic field in Europe, added a very special note to this gathering. In this perspective article we summarize some of the most outstanding data and advances on plant chromatin research presented at this workshop.
KW - EWPC2019
KW - chromatin
KW - epigenetics
KW - transcription
KW - nucleus
Y1 - 2020
U6 - https://doi.org/10.3389/fpls.2019.01795
SN - 1664-462X
VL - 10
IS - 1795
SP - 1
EP - 12
PB - Frontiers Media
CY - Lausanne
ER -
TY - GEN
A1 - Gorski, Mathias
A1 - Jung, Bettina
A1 - Li, Yong
A1 - Matias-Garcia, Pamela R.
A1 - Wuttke, Matthias
A1 - Coassin, Stefan
A1 - Thio, Chris H. L.
A1 - Kleber, Marcus E.
A1 - Winkler, Thomas W.
A1 - Wanner, Veronika
A1 - Chai, Jin-Fang
A1 - Chu, Audrey Y.
A1 - Cocca, Massimiliano
A1 - Feitosa, Mary F.
A1 - Ghasemi, Sahar
A1 - Hoppmann, Anselm
A1 - Horn, Katrin
A1 - Li, Man
A1 - Nutile, Teresa
A1 - Scholz, Markus
A1 - Sieber, Karsten B.
A1 - Teumer, Alexander
A1 - Tin, Adrienne
A1 - Wang, Judy
A1 - Tayo, Bamidele O.
A1 - Ahluwalia, Tarunveer S.
A1 - Almgren, Peter
A1 - Bakker, Stephan J. L.
A1 - Banas, Bernhard
A1 - Bansal, Nisha
A1 - Biggs, Mary L.
A1 - Boerwinkle, Eric
A1 - Böttinger, Erwin
A1 - Brenner, Hermann
A1 - Carroll, Robert J.
A1 - Chalmers, John
A1 - Chee, Miao-Li
A1 - Chee, Miao-Ling
A1 - Cheng, Ching-Yu
A1 - Coresh, Josef
A1 - de Borst, Martin H.
A1 - Degenhardt, Frauke
A1 - Eckardt, Kai-Uwe
A1 - Endlich, Karlhans
A1 - Franke, Andre
A1 - Freitag-Wolf, Sandra
A1 - Gampawar, Piyush
A1 - Gansevoort, Ron T.
A1 - Ghanbari, Mohsen
A1 - Gieger, Christian
A1 - Hamet, Pavel
A1 - Ho, Kevin
A1 - Hofer, Edith
A1 - Holleczek, Bernd
A1 - Foo, Valencia Hui Xian
A1 - Hutri-Kahonen, Nina
A1 - Hwang, Shih-Jen
A1 - Ikram, M. Arfan
A1 - Josyula, Navya Shilpa
A1 - Kahonen, Mika
A1 - Khor, Chiea-Chuen
A1 - Koenig, Wolfgang
A1 - Kramer, Holly
A1 - Kraemer, Bernhard K.
A1 - Kuehnel, Brigitte
A1 - Lange, Leslie A.
A1 - Lehtimaki, Terho
A1 - Lieb, Wolfgang
A1 - Loos, Ruth J. F.
A1 - Lukas, Mary Ann
A1 - Lyytikainen, Leo-Pekka
A1 - Meisinger, Christa
A1 - Meitinger, Thomas
A1 - Melander, Olle
A1 - Milaneschi, Yuri
A1 - Mishra, Pashupati P.
A1 - Mononen, Nina
A1 - Mychaleckyj, Josyf C.
A1 - Nadkarni, Girish N.
A1 - Nauck, Matthias
A1 - Nikus, Kjell
A1 - Ning, Boting
A1 - Nolte, Ilja M.
A1 - O'Donoghue, Michelle L.
A1 - Orho-Melander, Marju
A1 - Pendergrass, Sarah A.
A1 - Penninx, Brenda W. J. H.
A1 - Preuss, Michael H.
A1 - Psaty, Bruce M.
A1 - Raffield, Laura M.
A1 - Raitakari, Olli T.
A1 - Rettig, Rainer
A1 - Rheinberger, Myriam
A1 - Rice, Kenneth M.
A1 - Rosenkranz, Alexander R.
A1 - Rossing, Peter
A1 - Rotter, Jerome
A1 - Sabanayagam, Charumathi
A1 - Schmidt, Helena
A1 - Schmidt, Reinhold
A1 - Schoettker, Ben
A1 - Schulz, Christina-Alexandra
A1 - Sedaghat, Sanaz
A1 - Shaffer, Christian M.
A1 - Strauch, Konstantin
A1 - Szymczak, Silke
A1 - Taylor, Kent D.
A1 - Tremblay, Johanne
A1 - Chaker, Layal
A1 - van der Harst, Pim
A1 - van der Most, Peter J.
A1 - Verweij, Niek
A1 - Voelker, Uwe
A1 - Waldenberger, Melanie
A1 - Wallentin, Lars
A1 - Waterworth, Dawn M.
A1 - White, Harvey D.
A1 - Wilson, James G.
A1 - Wong, Tien-Yin
A1 - Woodward, Mark
A1 - Yang, Qiong
A1 - Yasuda, Masayuki
A1 - Yerges-Armstrong, Laura M.
A1 - Zhang, Yan
A1 - Snieder, Harold
A1 - Wanner, Christoph
A1 - Boger, Carsten A.
A1 - Kottgen, Anna
A1 - Kronenberg, Florian
A1 - Pattaro, Cristian
A1 - Heid, Iris M.
T1 - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2 - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19
KW - acute kidney injury
KW - end-stage kidney disease
KW - genome-wide association
KW - study
KW - rapid eGFRcrea decline
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS - 19
ER -
TY - JOUR
A1 - Rothwell, Joseph A.
A1 - Murphy, Neil
A1 - Aleksandrova, Krasimira
A1 - Schulze, Matthias Bernd
A1 - Bešević, Jelena
A1 - Kliemann, Nathalie
A1 - Jenab, Mazda
A1 - Ferrari, Pietro
A1 - Achaintre, David
A1 - Gicquiau, Audrey
A1 - Vozar, Béatrice
A1 - Scalbert, Augustin
A1 - Huybrechts, Inge
A1 - Freisling, Heinz
A1 - Prehn, Cornelia
A1 - Adamski, Jerzy
A1 - Cross, Amanda J.
A1 - Pala, Valeria Maria
A1 - Boutron-Ruault, Marie-Christine
A1 - Dahm, Christina C.
A1 - Overvad, Kim
A1 - Gram, Inger Torhild
A1 - Sandanger, Torkjel M.
A1 - Skeie, Guri
A1 - Jakszyn, Paula
A1 - Tsilidis, Kostas K.
A1 - Hughes, David J.
A1 - van Guelpen, Bethany
A1 - Bodén, Stina
A1 - Sánchez, Maria-José
A1 - Schmidt, Julie A.
A1 - Katzke, Verena
A1 - Kühn, Tilman
A1 - Colorado-Yohar, Sandra
A1 - Tumino, Rosario
A1 - Bueno-de-Mesquita, Bas
A1 - Vineis, Paolo
A1 - Masala, Giovanna
A1 - Panico, Salvatore
A1 - Eriksen, Anne Kirstine
A1 - Tjønneland, Anne
A1 - Aune, Dagfinn
A1 - Weiderpass, Elisabete
A1 - Severi, Gianluca
A1 - Chajès, Véronique
A1 - Gunter, Marc J.
T1 - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
JF - Clinical gastroenterology and hepatology
N2 - BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.
RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants.
CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
KW - colorectal neoplasm
KW - risk factors
KW - World Cancer Research Fund/American Institute for Cancer Research Recommendations
KW - targeted metabolomics
Y1 - 2020
U6 - https://doi.org/10.1016/j.cgh.2020.11.045
SN - 1542-3565
SN - 1542-7714
VL - 20
SP - E1061
EP - E1082
PB - Elsevier
CY - New York, NY
ER -
TY - JOUR
A1 - Sigel, Keith Magnus
A1 - Swartz, Talia H.
A1 - Golden, Eddye
A1 - Paranjpe, Ishan
A1 - Somani, Sulaiman
A1 - Richter, Felix
A1 - De Freitas, Jessica K.
A1 - Miotto, Riccardo
A1 - Zhao, Shan
A1 - Polak, Paz
A1 - Mutetwa, Tinaye
A1 - Factor, Stephanie
A1 - Mehandru, Saurabh
A1 - Mullen, Michael
A1 - Cossarini, Francesca
A1 - Böttinger, Erwin
A1 - Fayad, Zahi
A1 - Merad, Miriam
A1 - Gnjatic, Sacha
A1 - Aberg, Judith
A1 - Charney, Alexander
A1 - Nadkarni, Girish
A1 - Glicksberg, Benjamin S.
T1 - Coronavirus 2019 and people living with human immunodeficiency virus
BT - outcomes for hospitalized patients in New York City
JF - Clinical infectious diseases : electronic edition
N2 - Background:
There are limited data regarding the clinical impact of coronavirus disease 2019 (COVID-19) on people living with human immunodeficiency virus (PLWH). In this study, we compared outcomes for PLWH with COVID-19 to a matched comparison group.
Methods:
We identified 88 PLWH hospitalized with laboratory-confirmed COVID-19 in our hospital system in New York City between 12 March and 23 April 2020. We collected data on baseline clinical characteristics, laboratory values, HIV status, treatment, and outcomes from this group and matched comparators (1 PLWH to up to 5 patients by age, sex, race/ethnicity, and calendar week of infection). We compared clinical characteristics and outcomes (death, mechanical ventilation, hospital discharge) for these groups, as well as cumulative incidence of death by HIV status.
Results:
Patients did not differ significantly by HIV status by age, sex, or race/ethnicity due to the matching algorithm. PLWH hospitalized with COVID-19 had high proportions of HIV virologic control on antiretroviral therapy. PLWH had greater proportions of smoking (P < .001) and comorbid illness than uninfected comparators. There was no difference in COVID-19 severity on admission by HIV status (P = .15). Poor outcomes for hospitalized PLWH were frequent but similar to proportions in comparators; 18% required mechanical ventilation and 21% died during follow-up (compared with 23% and 20%, respectively). There was similar cumulative incidence of death over time by HIV status (P = .94).
Conclusions:
We found no differences in adverse outcomes associated with HIV infection for hospitalized COVID-19 patients compared with a demographically similar patient group.
KW - human immunodeficiency virus
KW - coronavirus 2019
KW - severe acute respiratory
KW - syndrome coronavirus 2
Y1 - 2020
U6 - https://doi.org/10.1093/cid/ciaa880
SN - 1058-4838
SN - 1537-6591
VL - 71
IS - 11
SP - 2933
EP - 2938
PB - Oxford Univ. Press
CY - Cary, NC
ER -