TY - JOUR A1 - Topuz, Birol T1 - Quranic verses shaping Djem and false perception of Alevism in the society JF - International journal of islamic thought : IJIT N2 - It is seen that the Alevi-Sunni relations are mostly shaped by the stereotyped perceptions of the two groups about each other. In particular, the fact that Alevism is a closed society due to the pressure they have experienced throughout history has prevented them from being perceived correctly. As such, it is seen that there are many misconceptions about Alevis and their rituals that do not match the reality but are accepted as correct by the society. Due to the lack of communication that could not be developed through this "unknown" in the historical process, Alevi-Sunni relations have always been open to manipulations. As a matter of fact, it is seen that Alevis' relations with Islam, the Djem ceremonies that form the basis of Alevism, and the content of Djem ceremonies have always remained a mystery to Sunnis. Unfortunately, this misperception also reflected negatively on the communication between the two groups. As it is known, if stereotypes arise when there is incorrect information about the target group, the best way to correct them is to create common contact environments that will bring individuals to the right information. Here in this article, the unknown Djem ritual and especially the Qur'anic verses that they refer to during the Djem ceremonies are discussed. KW - words KW - Alevis KW - Sunnis KW - Djem KW - verses of Quran in Djem Y1 - 2022 U6 - https://doi.org/10.24035/ijit.21.2022.223 SN - 2232-1314 SN - 2289-6023 VL - 21 SP - 35 EP - 45 PB - University of Kebansaan, Malaysia CY - Kuala Lumpur ER - TY - JOUR A1 - Hilgers, Leon A1 - Hartmann, Stefanie A1 - Pfaender, Jobst A1 - Lentge-Maass, Nora A1 - Marwoto, Ristiyanti M. A1 - von Rintelen, Thomas A1 - Hofreiter, Michael T1 - Evolutionary divergence and radula diversification in two ecomorphs from an adaptive radiation of freshwater snails JF - Genes N2 - (1) Background: Adaptive diversification of complex traits plays a pivotal role in the evolution of organismal diversity. In the freshwater snail genus Tylomelania, adaptive radiations were likely promoted by trophic specialization via diversification of their key foraging organ, the radula. (2) Methods: To investigate the molecular basis of radula diversification and its contribution to lineage divergence, we used tissue-specific transcriptomes of two sympatric Tylomelania sarasinorum ecomorphs. (3) Results: We show that ecomorphs are genetically divergent lineages with habitat-correlated abundances. Sequence divergence and the proportion of highly differentially expressed genes are significantly higher between radula transcriptomes compared to the mantle and foot. However, the same is not true when all differentially expressed genes or only non-synonymous SNPs are considered. Finally, putative homologs of some candidate genes for radula diversification (hh, arx, gbb) were also found to contribute to trophic specialization in cichlids and Darwin's finches. (4) Conclusions: Our results are in line with diversifying selection on the radula driving Tylomelania ecomorph divergence and indicate that some molecular pathways may be especially prone to adaptive diversification, even across phylogenetically distant animal groups. KW - speciation KW - adaptive radiation KW - molluscs KW - RNAseq KW - regulatory evolution KW - trophic specialization Y1 - 2022 U6 - https://doi.org/10.3390/genes13061029 SN - 2073-4425 VL - 13 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Escalante, Ignacio A1 - Dominguez, Marisol A1 - Gomez-Ruiz, Daisy Alejandra A1 - Machado, Glauco T1 - Benefits and costs of mixed-species aggregations in Harvestmen (Arachnida: Opiliones) JF - Frontiers in ecology and evolution N2 - Many animals form aggregations with individuals of the same species (single-species aggregations, SSA). Less frequently, individuals may also aggregate with individuals of other species (mixed-species aggregations, MSA). Although the benefits and costs of SSA have been intensively studied, the same is not true for MSA. Here, we first review the cases of MSA in harvestmen, an arachnid order in which the records of MSA are more frequent than other arthropod orders. We then propose several benefits and costs of MSA in harvestmen, and contrast them with those of SSA. Second, using field-gathered data we describe gregariousness in seven species of Prionostemma harvestmen from Costa Rica. These species form MSA, but individuals are also found solitarily or in SSA. We tested one possible benefit and one possible cost of gregariousness in Prionostemma harvestmen. Regarding the benefit, we hypothesized that individuals missing legs would be more exposed to predation than eight-legged individuals and thus they should be found preferentially in aggregations, where they would be more protected from predators. Our data, however, do not support this hypothesis. Regarding the cost, we hypothesized that gregariousness increases the chances of parasitism. We found no support for this hypothesis either because both mite prevalence and infestation intensity did not differ between solitary or aggregated individuals. Additionally, the type of aggregation (SSA or MSA) was not associated with the benefit or the cost we explored. This lack of effect may be explained by the fluid membership of the aggregations, as we found high turnover over time in the number of individuals and species composition of the aggregations. In conclusion, we hope our review and empirical data stimulate further studies on MSA, which remains one of the most elusive forms of group living in animals. KW - alarm signals KW - aggregation size KW - autotomy KW - chemical defenses KW - dilution KW - effect KW - ectoparasitism KW - group living KW - roosting site Y1 - 2022 U6 - https://doi.org/10.3389/fevo.2021.766323 SN - 2296-701X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Dijkstra, Hylke A1 - Debre, Maria Josepha T1 - The death of major international organizations BT - when institutional stickiness is not enough JF - Global studies quarterly N2 - Major international organizations (IOs) are heavily contested, but they are rarely dissolved. Scholars have focused on their longevity, making institutional arguments about replacement costs and institutional assets as well as IO agency to adapt and resist challenges. This article analyzes the limits of institutional stickiness by focusing on outlier cases. While major IOs are dissolved at considerably lower rates than minor IOs, the article nevertheless identifies twenty-one cases where major IOs have died since 1815. These are tough cases as they do not conform to our institutionalist expectations. To better understand these rare but important events, the article provides case illustrations from the League of Nations and International Refugee Organization, which were dissolved due to their perceived underperformance and a disappearing demand for cooperation. These cases show the limits of the institutional theories of IO stickiness: sometimes member states find high replacement costs justified or consider assets as sunk costs, and IOs may lack agency to strategically respond. This article refines theories of institutional stickiness and contributes to the institutional theory of the life and death of IOs. Les principales organisations internationales (OI) sont fortement contestées, mais rarement dissoutes. Pour expliquer leur longévité, les chercheurs ont avancé des arguments institutionnels concernant les coûts de remplacement et les actifs de l'institution, mais aussi la capacité des OI à s'adapter et à résister aux défis. Cet article analyse les limites de la persistance des institutions en se concentrant sur des cas particuliers. Tandis que les principales OI sont dissoutes bien moins fréquemment que des OI moins importantes, cet article identifie néanmoins 21 cas de disparition d'OI principales depuis 1815. Ces derniers sont particulièrement difficiles, car ils ne correspondent pas à nos attentes en termes d'institutions. Afin de mieux comprendre ces événements rares, mais non moins importants, l'article propose comme illustrations de cas la Société des Nations et l'Organisation internationale pour les réfugiés, qui ont été dissoutes à cause de leur manque apparent de résultats et de la disparition de la demande de coopération. Ces cas mettent en évidence les limites des théories institutionnelles de persistance des OI : parfois, les États membres considèrent les coûts de remplacement élevés justifiés ou les actifs comme des coûts irrécupérables, et les OI n'ont peut-être pas la capacité de leur répondre de manière stratégique. Le présent article affine les théories de persistance institutionnelle et contribue à la théorie institutionnelle de vie et de mort des OI. Las organizaciones internacionales (OI) más importantes son muy cuestionadas, pero rara vez se disuelven. Los investigadores se han centrado en la longevidad de las IO, formulando argumentos institucionales sobre los costes de sustitución y los activos institucionales, así como sobre la capacidad de adaptación y resistencia de las organizaciones internacionales. Este artículo analiza los límites de la rigidez institucional centrándose en casos atípicos. Aunque las OI más importantes se disuelven en proporciones considerablemente menores que las OI de menor importancia, el artículo identifica 21 casos en los que OI más importantes desaparecieron desde 1815. Se trata de casos difíciles, ya que no se ajustan a nuestras expectativas institucionalistas. Para comprender mejor estos raros pero importantes acontecimientos, el artículo ofrece ejemplos de casos de la Sociedad de Naciones y de la, Organización Internacional para los Refugiados que se disolvieron debido a su bajo desempeño percibido y a la desaparición de la demanda de cooperación. Estos casos muestran los límites de las teorías institucionales sobre la rigidez de las OI: En ocasiones, los Estados miembros consideran justificados los elevados costes de sustitución o consideran que los activos son costes irrecuperables, y las OI pueden no disponer de capacidad de respuesta estratégica. Este artículo profundiza en las teorías de la rigidez institucional y contribuye a la teoría institucional de la vida y la muerte de las organizaciones internacionales. Y1 - 2022 U6 - https://doi.org/10.1093/isagsq/ksac048 SN - 2634-3797 VL - 2 IS - 4 SP - 1 EP - 13 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Bryant, Seth A1 - Davies, Evan A1 - Sol, David A1 - Davis, Sandy T1 - The progression of flood risk in southern Alberta since the 2013 flood JF - Journal of flood risk management N2 - After a century of semi-restricted floodplain development, Southern Alberta, Canada, was struck by the devastating 2013 Flood. Aging infrastructure and limited property-level floodproofing likely contributed to the $4-6 billion (CAD) losses. Following this catastrophe, Alberta has seen a revival in flood management, largely focused on structural protections. However, concurrent with the recent structural work was a 100,000+ increase in Calgary's population in the 5 years following the flood, leading to further densification of high-hazard areas. This study implements the novel Stochastic Object-based Flood damage Dynamic Assessment (SOFDA) model framework to quantify the progression of the direct-damage flood risk in a mature urban neighborhood after the 2013 Flood. Five years of remote-sensing data, property assessment records, and inundation simulations following the flood are used to construct the model. Results show that in these 5 years, vulnerability trends (like densification) have increased flood risk by 4%; however, recent structural mitigation projects have reduced overall flood risk by 47% for this case study. These results demonstrate that the flood management revival in Southern Alberta has largely been successful at reducing flood risk; however, the gains are under threat from continued development and densification absent additional floodproofing regulations. KW - Calgary KW - depth-damage functions KW - expected annual damages KW - flood risk KW - model KW - property level protection measures KW - risk analysis KW - risk dynamics Y1 - 2022 U6 - https://doi.org/10.1111/jfr3.12811 SN - 1753-318X VL - 15 IS - 3 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Minutillo, Serena A. A1 - Ruano-Rosa, David A1 - Abdelfattah, Ahmed A1 - Schena, Leonardo A1 - Malacrino, Antonino T1 - The fungal microbiome of wheat flour includes potential mycotoxin producers JF - Foods N2 - Consumers are increasingly demanding higher quality and safety standards for the products they consume, and one of this is wheat flour, the basis of a wide variety of processed products. This major component in the diet of many communities can be contaminated by microorganisms before the grain harvest, or during the grain storage right before processing. These microorganisms include several fungal species, many of which produce mycotoxins, secondary metabolites that can cause severe acute and chronic disorders. Yet, we still know little about the overall composition of fungal communities associated with wheat flour. In this study, we contribute to fill this gap by characterizing the fungal microbiome of different types of wheat flour using culture-dependent and -independent techniques. Qualitatively, these approaches suggested similar results, highlighting the presence of several fungal taxa able to produce mycotoxins. In-vitro isolation of fungal species suggest a higher frequency of Penicillium, while metabarcoding suggest a higher abundance of Alternaria. This discrepancy might reside on the targeted portion of the community (alive vs. overall) or in the specific features of each technique. Thus, this study shows that commercial wheat flour hosts a wide fungal diversity with several taxa potentially representing concerns for consumers, aspects that need more attention throughout the food production chain. KW - Penicillium KW - Alternaria KW - post-harvest KW - metabarcoding Y1 - 2022 U6 - https://doi.org/10.3390/foods11050676 SN - 2304-8158 VL - 11 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wassermann, Birgit A1 - Abdelfattah, Ahmed A1 - Wicaksono, Wisnu Adi A1 - Kusstatscher, Peter A1 - Müller, Henry A1 - Cernava, Tomislav A1 - Goertz, Simon A1 - Rietz, Steffen A1 - Abbadi, Amine A1 - Berg, Gabriele T1 - The Brassica napus seed microbiota is cultivar-specific and transmitted via paternal breeding lines JF - Microbial biotechnology N2 - Seed microbiota influence germination and plant health and have the potential to improve crop performance, but the factors that determine their structure and functions are still not fully understood. Here, we analysed the impact of plant-related and external factors on seed endophyte communities of 10 different oilseed rape (Brassica napus L.) cultivars from 26 field sites across Europe. All seed lots harboured a high abundance and diversity of endophytes, which were dominated by six genera: Ralstonia, Serratia, Enterobacter, Pseudomonas, Pantoea, and Sphingomonas. The cultivar was the main factor explaining the variations in bacterial diversity, abundance and composition. In addition, the latter was significantly influenced by diverse biotic and abiotic factors, for example host germination rates and disease resistance against Plasmodiophora brassicae. A set of bacterial biomarkers was identified to discriminate between characteristics of the seeds, for example Sphingomonas for improved germination and Brevundimonas for disease resistance. Application of a Bayesian community approach suggested vertical transmission of seed endophytes, where the paternal parent plays a major role and might even determine the germination performance of the offspring. This study contributes to the understanding of seed microbiome assembly and underlines the potential of the microbiome to be implemented in crop breeding and biocontrol programmes. Y1 - 2022 U6 - https://doi.org/10.1111/1751-7915.14077 SN - 1751-7915 VL - 15 IS - 9 SP - 2379 EP - 2390 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Stolpmann, Lydia A1 - Mollenhauer, Gesine A1 - Morgenstern, Anne A1 - Hammes, Jens S. A1 - Boike, Julia A1 - Overduin, Pier Paul A1 - Grosse, Guido T1 - Origin and pathways of dissolved organic carbon in a small catchment in the Lena River Delta JF - Frontiers in Earth Science N2 - The Arctic is rich in aquatic systems and experiences rapid warming due to climate change. The accelerated warming causes permafrost thaw and the mobilization of organic carbon. When dissolved organic carbon is mobilized, this DOC can be transported to aquatic systems and degraded in the water bodies and further downstream. Here, we analyze the influence of different landscape components on DOC concentrations and export in a small (6.45 km(2)) stream catchment in the Lena River Delta. The catchment includes lakes and ponds, with the flow path from Pleistocene yedoma deposits across Holocene non-yedoma deposits to the river outlet. In addition to DOC concentrations, we use radiocarbon dating of DOC as well as stable oxygen and hydrogen isotopes (delta O-18 and delta D) to assess the origin of DOC. We find significantly higher DOC concentrations in the Pleistocene yedoma area of the catchment compared to the Holocene non-yedoma area with medians of 5 and 4.5 mg L-1 (p < 0.05), respectively. When yedoma thaw streams with high DOC concentration reach a large yedoma thermokarst lake, we observe an abrupt decrease in DOC concentration, which we attribute to dilution and lake processes such as mineralization. The DOC ages in the large thermokarst lake (between 3,428 and 3,637 C-14 y BP) can be attributed to a mixing of mobilized old yedoma and Holocene carbon. Further downstream after the large thermokarst lake, we find progressively younger DOC ages in the stream water to its mouth, paired with decreasing DOC concentrations. This process could result from dilution with leaching water from Holocene deposits and/or emission of ancient yedoma carbon to the atmosphere. Our study shows that thermokarst lakes and ponds may act as DOC filters, predominantly by diluting incoming waters of higher DOC concentrations or by re-mineralizing DOC to CO2 and CH4. Nevertheless, our results also confirm that the small catchment still contributes DOC on the order of 1.2 kg km(-2) per day from a permafrost landscape with ice-rich yedoma deposits to the Lena River. KW - Arctic lakes KW - ice complex KW - yedoma KW - thermokarst lakes KW - DOC KW - aquatic carbon cycle KW - permafrost KW - radiocarbon dating Y1 - 2022 U6 - https://doi.org/10.3389/feart.2021.759085 SN - 2296-6463 VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Hänel, Hilkje C. T1 - Einleitung: Epistemische Ungerechtigkeiten T1 - Introduction: epistemic injustice JF - Zeitschrift für praktische Philosophie N2 - Die Debatte um epistemische Ungerechtigkeit verbindet normative Gerechtigkeitstheorien mit erkenntnistheoretischen Theorien und stellt somit die Art von wichtigen Fragen, die in den letzten Jahren sowohl innerhalb als auch außerhalb der Wissenschaft internationale Aufmerksamkeit erfahren haben. Verwiesen sei hier etwa auf soziale Bewegungen wie #MeToo und #BlackLivesMatter zeigen. Theorien der epistemischen Ungerechtigkeit (sowie verwandte Theorien wie Epistemologie des Unwissens, feministische Erkenntnistheorie und Standpunkttheorie) können sowohl epistemische Praktiken analysieren und einen Beitrag zu Gerechtigkeitstheorien und sozialer Epistemologie liefern, als auch zu adäquateren Verständnissen von existierenden Ungerechtigkeiten beitragen. In dem hier vorliegenden Schwerpunkt werden Beiträge zu eben solchen bislang wenig erforschten Ungerechtigkeiten sowie neue Diskussionsbeiträge zur Debatte um epistemische Ungerechtigkeiten geliefert. N2 - The debate of epistemic injustice combines normative theories of justice with epistemological theories, posing the kinds of important questions that have received international attention in recent years, both inside and outside academia. Examples of the public relevance of the issue are social movements such as #MeToo and #BlackLivesMatter. Theories of epistemic injustice (and related theories such as epistemology of ignorance, feminist epistemology, and standpoint epistemology) can both analyze epistemic practices and contribute to theories of justice, social epistemology, and neighboring fields, as well as provide more adequate understandings of existing injustices. The special issue contributes to the analysis of such existing, yet under-researched injustices and new contributions to the debate on epistemic injustices. KW - Epistemische Ungerechtigkeit KW - Unwissen KW - feministische Erkenntnistheorie KW - Standpunkttheorie KW - soziale Bewegungen KW - epistemic injustice KW - ignorance KW - feminist epistemology KW - standpoint-theory KW - social movements Y1 - 2022 U6 - https://doi.org/10.22613/zfpp/9.1.5 SN - 2409-9961 VL - 9 IS - 1 SP - 141 EP - 154 PB - Universität Salzburg, Zentrum für Ethik und Armutsforschung CY - Salzburg ER - TY - JOUR A1 - Inceoglu, Fadil A1 - Shprits, Yuri A1 - Heinemann, Stephan G. A1 - Bianco, Stefano T1 - Identification of coronal holes on AIA/SDO images using unsupervised machine learning JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - Through its magnetic activity, the Sun governs the conditions in Earth's vicinity, creating space weather events, which have drastic effects on our space- and ground-based technology. One of the most important solar magnetic features creating the space weather is the solar wind that originates from the coronal holes (CHs). The identification of the CHs on the Sun as one of the source regions of the solar wind is therefore crucial to achieve predictive capabilities. In this study, we used an unsupervised machine-learning method, k-means, to pixel-wise cluster the passband images of the Sun taken by the Atmospheric Imaging Assembly on the Solar Dynamics Observatory in 171, 193, and 211 angstrom in different combinations. Our results show that the pixel-wise k-means clustering together with systematic pre- and postprocessing steps provides compatible results with those from complex methods, such as convolutional neural networks. More importantly, our study shows that there is a need for a CH database where a consensus about the CH boundaries is reached by observers independently. This database then can be used as the "ground truth," when using a supervised method or just to evaluate the goodness of the models. Y1 - 2022 U6 - https://doi.org/10.3847/1538-4357/ac5f43 SN - 1538-4357 VL - 930 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Asante, Drusilla Obenewaa A1 - Osei, Francis A1 - Abdul-Samed, Fridaus A1 - Nanevie, Victoria Dzifa T1 - Knowledge and participation in exercise and physical activity among pregnant women in Ho, Ghana JF - Frontiers in Public Health N2 - Background Physical activity (PA) and exercise have been identified to improve the general fitness and health. Although, the Pregnancy Physical Activity Questionnaire (PPAQ) has been validated for use in assessing PA in pregnant women. However, understanding the knowledge and participation levels of PA in pregnant women in the underdeveloped regions of Ghana is of clinical relevance to foster education and promotion of PA. In Ghana, pregnant women believe the "myth" (mostly in rural areas and underdeveloped regions) that exercising in the first trimester might lead to miscarriage. Thus, the main objective of this study was to investigate the extent of knowledge and participation levels in PA among pregnant women in Ho, Ghana using a self-developed questionnaire which consisted of some questions adapted from the PPAQ. MethodsSeventy-seven (n = 77) pregnant women between the ages of 18-50 years were recruited from three hospitals across the Ho municipality of Ghana. A self-developed questionnaire which consisted of some questions taken from the PPAQ was administered to participants under the researchers' supervision. Spearman's correlation analysis was used to find the association between the level of participation in PA, knowledge of PA and gestational age among pregnant women. Results From the total participants (n = 77) recruited, 57 (74%) of the participants scored high in PA knowledge. Most of the participants 48 (62.3%) answered that PA promotes healthy pregnancy. Participants who reported barriers to PA during pregnancy were no exercise habits 51 (66.2%), having no time 17 (22.1%) and fear of miscarriage 9 (11.7%). There was a significant (p < 0.05) association between the level of participation and gestational age. No significant (p > 0.05) association between the level of participation and knowledge of PA was observed. Conclusion There is a high level of knowledge of PA among pregnant women in Ho, Ghana. However, most pregnant women rather engage in PA as their gestational age increases. Thus, to foster sustainable exercise participation during pregnancy, all healthcare providers saddled with the responsibility of providing maternal healthcare must strengthen the education and promotion of exercise and PA among pregnant women in Ho, Ghana. KW - physical activity KW - barriers to physical activity KW - education KW - pregnancy KW - gestational age Y1 - 2022 U6 - https://doi.org/10.3389/fpubh.2022.927191 SN - 2296-2565 VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - von Steinkeller, Annika A1 - Grosse, Gerlind T1 - Children are more social when playing analog games together than digital games JF - Computers in Human Behavior Reports N2 - Digital media are being used more and more frequently by children and for a wide variety of functions. However, there are no studies to date that examine the effect of such use on peer interactions and the occurrence of prosocial behavior in peers. For parents, it has been found that when using digital media only few parents respond responsively to their children's attempts at interaction and also very rarely, they communicate with them verbally and nonverbally. In the present study, we investigated how playing a game in a digital versus analog form influences in-teractions (especially prosocial behavior) of peers. We used an experimental situation, where 24 dyads of 4-10-year-old children were examined. Each of the dyads was randomly assigned to a condition where they played either a digital or analog game together. Various interaction parameters and prosocial behavior during and after the game were analyzed. Results show that children in the analog condition communicated verbally with each other more often, responded more often to interaction attempts of their partners and showed less often negative forms of inter-action and more often positive forms of interaction than children in the digital condition. However, the type of medium had no influence on prosocial behavior after the game situation. These results suggest that the format of a game (digital vs. analog) has a decisive influence on peer interactions concerning their communication during but not their prosocial behavior after the game situation. KW - child development KW - peer interactions KW - media KW - prosocial behavior KW - digital KW - games Y1 - 2022 U6 - https://doi.org/10.1016/j.chbr.2022.100195 SN - 2451-9588 VL - 6 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Smirnov, Artem A1 - Shprits, Yuri A1 - Allison, Hayley A1 - Aseev, Nikita A1 - Drozdov, Alexander A1 - Kollmann, Peter A1 - Wang, Dedong A1 - Saikin, Anthony T1 - Storm-Time evolution of the Equatorial Electron Pitch Angle Distributions in Earth's Outer Radiation Belt JF - Frontiers in astronomy and space sciences N2 - In this study we analyze the storm-time evolution of equatorial electron pitch angle distributions (PADs) in the outer radiation belt region using observations from the Magnetic Electron Ion Spectrometer (MagEIS) instrument aboard the Van Allen Probes in 2012-2019. The PADs are approximated using a sum of the first, third and fifth sine harmonics. Different combinations of the respective coefficients refer to the main PAD shapes within the outer radiation belt, namely the pancake, flat-top, butterfly and cap PADs. We conduct a superposed epoch analysis of 129 geomagnetic storms and analyze the PAD evolution for day and night MLT sectors. PAD shapes exhibit a strong energy-dependent response. At energies of tens of keV, the PADs exhibit little variation throughout geomagnetic storms. Cap PADs are mainly observed at energies < 300 keV, and their extent in L shrinks with increasing energy. The cap distributions transform into the pancake PADs around the main phase of the storm on the nightside, and then come back to their original shapes during the recovery phase. At higher energies on the dayside, the PADs are mainly pancake during pre-storm conditions and become more anisotropic during the main phase. The quiet-time butterfly PADs can be observed on the nightside at L> 5.6. During the main phase, butterfly PADs have stronger 90 degrees-minima and can be observed at lower L-shells (down to L = 5), then transitioning into flat-top PADs at L similar to 4.5 - 5 and pancake PADs at L < 4.5. The resulting PAD coefficients for different energies, locations and storm epochs can be used to test the wave models and physics-based radiation belt codes in terms of pitch angle distributions. KW - pitch angle KW - pitch angle distributions KW - electrons KW - radiation belts KW - magnetosphere KW - van alien probes Y1 - 2022 U6 - https://doi.org/10.3389/fspas.2022.836811 SN - 2296-987X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Adolfs, Marjolijn A1 - Hoque, Mohammed Mainul A1 - Shprits, Yuri T1 - Storm-time relative total electron content modelling using machine learning techniques JF - Remote sensing N2 - Accurately predicting total electron content (TEC) during geomagnetic storms is still a challenging task for ionospheric models. In this work, a neural-network (NN)-based model is proposed which predicts relative TEC with respect to the preceding 27-day median TEC, during storm time for the European region (with longitudes 30 degrees W-50 degrees E and latitudes 32.5 degrees N-70 degrees N). The 27-day median TEC (referred to as median TEC), latitude, longitude, universal time, storm time, solar radio flux index F10.7, global storm index SYM-H and geomagnetic activity index Hp30 are used as inputs and the output of the network is the relative TEC. The relative TEC can be converted to the actual TEC knowing the median TEC. The median TEC is calculated at each grid point over the European region considering data from the last 27 days before the storm using global ionosphere maps (GIMs) from international GNSS service (IGS) sources. A storm event is defined when the storm time disturbance index Dst drops below 50 nanotesla. The model was trained with storm-time relative TEC data from the time period of 1998 until 2019 (2015 is excluded) and contains 365 storms. Unseen storm data from 33 storm events during 2015 and 2020 were used to test the model. The UQRG GIMs were used because of their high temporal resolution (15 min) compared to other products from different analysis centers. The NN-based model predictions show the seasonal behavior of the storms including positive and negative storm phases during winter and summer, respectively, and show a mixture of both phases during equinoxes. The model's performance was also compared with the Neustrelitz TEC model (NTCM) and the NN-based quiet-time TEC model, both developed at the German Aerospace Agency (DLR). The storm model has a root mean squared error (RMSE) of 3.38 TEC units (TECU), which is an improvement by 1.87 TECU compared to the NTCM, where an RMSE of 5.25 TECU was found. This improvement corresponds to a performance increase by 35.6%. The storm-time model outperforms the quiet-time model by 1.34 TECU, which corresponds to a performance increase by 28.4% from 4.72 to 3.38 TECU. The quiet-time model was trained with Carrington averaged TEC and, therefore, is ideal to be used as an input instead of the GIM derived 27-day median. We found an improvement by 0.8 TECU which corresponds to a performance increase by 17% from 4.72 to 3.92 TECU for the storm-time model using the quiet-time-model predicted TEC as an input compared to solely using the quiet-time model. KW - ionosphere KW - relative total electron content KW - geomagnetic storms KW - neural KW - networks KW - NTCM KW - European storm-time model Y1 - 2022 U6 - https://doi.org/10.3390/rs14236155 SN - 2072-4292 VL - 14 IS - 23 PB - MDPI CY - Basel ER - TY - JOUR A1 - Prol, Fabricio S. A1 - Smirnov, Artem G. A1 - Hoque, M. Mainul A1 - Shprits, Yuri T1 - Combined model of topside ionosphere and plasmasphere derived from radio-occultation and Van Allen Probes data JF - Scientific reports N2 - In the last years, electron density profile functions characterized by a linear dependence on the scale height showed good results when approximating the topside ionosphere. The performance above 800 km, however, is not yet well investigated. This study investigates the capability of the semi-Epstein functions to represent electron density profiles from the peak height up to 20,000 km. Electron density observations recorded by the Van Allen Probes were used to resolve the scale height dependence in the plasmasphere. It was found that the linear dependence of the scale height in the topside ionosphere cannot be directly used to extrapolate profiles above 800 km. We find that the dependence of scale heights on altitude is quadratic in the plasmasphere. A statistical model of the scale heights is therefore proposed. After combining the topside ionosphere and plasmasphere by a unified model, we have obtained good estimations not only in the profile shapes, but also in the Total Electron Content magnitude and distributions when compared to actual measurements from 2013, 2014, 2016 and 2017. Our investigation shows that Van Allen Probes can be merged to radio-occultation data to properly represent the upper ionosphere and plasmasphere by means of a semi-Epstein function. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-13302-1 SN - 2045-2322 VL - 12 IS - 1 PB - Macmillan Publishers Limited, part of Springer Nature CY - London ER - TY - JOUR A1 - Drozdov, Alexander A1 - Allison, Hayley J. A1 - Shprits, Yuri A1 - Usanova, Maria E. A1 - Saikin, Anthony A1 - Wang, Dedong T1 - Depletions of Multi-MeV Electrons and their association to Minima in Phase Space Density JF - Geophysical research letters N2 - Fast-localized electron loss, resulting from interactions with electromagnetic ion cyclotron (EMIC) waves, can produce deepening minima in phase space density (PSD) radial profiles. Here, we perform a statistical analysis of local PSD minima to quantify how readily these are associated with radiation belt depletions. The statistics of PSD minima observed over a year are compared to the Versatile Electron Radiation Belts (VERB) simulations, both including and excluding EMIC waves. The observed minima distribution can only be achieved in the simulation including EMIC waves, indicating their importance in the dynamics of the radiation belts. By analyzing electron flux depletions in conjunction with the observed PSD minima, we show that, in the heart of the outer radiation belt (L* < 5), on average, 53% of multi-MeV electron depletions are associated with PSD minima, demonstrating that fast localized loss by interactions with EMIC waves are a common and crucial process for ultra-relativistic electron populations. KW - radiation belts KW - EMIC KW - VERB KW - PSD Y1 - 2022 U6 - https://doi.org/10.1029/2021GL097620 SN - 0094-8276 SN - 1944-8007 VL - 49 IS - 8 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Szangolies, Leonna A1 - Rohwäder, Marie-Sophie A1 - Jeltsch, Florian T1 - Single large AND several small habitat patches BT - a community perspective on their importance for biodiversity JF - Basic and applied ecology : Journal of the Gesellschaft für Ökologie N2 - The debate whether single large or several small (SLOSS) patches benefit biodiversity has existed for decades, but recent literature provides increasing evidence for the importance of small habitats. Possible beneficial mechanisms include reduced presence of preda-tors and competitors in small habitat areas or specific functions such as stepping stones for dispersal. Given the increasing amount of studies highlighting individual behavioral differences that may influence these functions, we hypothesize that the advantage of small versus large habitat patches not only depends on patch functionality but also on the presence of animal personalities (i.e., risk-tolerant vs. risk-averse). Using an individual-based, spatially-explicit community model, we analyzed the diversity of mammal communities in landscapes consisting of a few large habitat islands interspersed with different amounts and sizes of small habitat patches. Within these heterogeneous environments, individuals compete for resources and form home-ranges, with only risk-tolerant individuals using habitat edges. Results show that when risk-tolerant individuals exist, small patches increase species diversity. A strong peak occurs at approximately 20% habitat cover in small patches when those small habitats are only used for foraging but not for breeding and home-range core position. Additional usage as stepping stones for juvenile dispersal further increases species persistence. Over-all, our results reveal that a combination of a few large and several small habitat patches promotes biodiversity by enhancing land-scape heterogeneity. Here, heterogeneity is created by pronounced differences in habitat functionality, increasing edge density, and variability in habitat use by different behavioral types. The finding that a combination of single large AND several small (SLASS) patches is needed for effective biodiversity preservation has implications for advancing landscape conservation. Particularly in struc-turally poor agricultural areas, modern technology enables precise management with the opportunity to create small foraging habitats by excluding less profitable agricultural land from cultivation. KW - SLOSS KW - fragmentation KW - heterogeneity KW - community KW - coexistence KW - coviability KW - competition KW - home-ranges KW - inter-individual difference KW - personality Y1 - 2022 U6 - https://doi.org/10.1016/j.baae.2022.09.004 SN - 1439-1791 SN - 1618-0089 VL - 65 SP - 16 EP - 27 PB - Elsevier CY - München ER - TY - JOUR A1 - Desch, Anke A1 - Förstner, Bernd Rainer A1 - Artmann, Jörg A1 - Häusler, Andreas A1 - Hauptmann, Michael A1 - Altin, Sibel Vildan A1 - Rapp, Michael A. A1 - Holmberg, Christine T1 - A theory of change of an innovation for therapeutic care and meaningful living in a German nursing home JF - BMC geriatrics N2 - Background: Demographic changes are leading to growing care needs of older people and creating a challenge for healthcare systems worldwide. Nursing homes (NHs) need to provide care for growing numbers of residents while ensuring a high-quality care. We aimed to examine an innovative NH in Germany and apply a theory of change (ToC) approach to develop a best practice model (BPM) for therapeutic care in NHs. Methods: A multimethod qualitative study conducted from February to July 2021 in Germany involved interviews with 14 staff members of an innovative NH and 10 directors and care managers of other NHs. The interview guidelines included questions on nursing practices, infrastructure, resources, interprofessional collaboration, and working culture. Additional material on the participating NH (website, promotion videos, newsletters, care documentation) were collected. Contextual literature on NH culture and therapeutic care in Germany, ToC methodology, and NH culture change were reviewed. Following a question-focused analysis of all material, we generated a ToC model towards a BPM of therapeutic care and meaningful living in NHs. Results: were verified in interdisciplinary team meetings, with study participants and other stakeholders to establish consensus. Results The participating NH's care concept aims to improve residents' functional abilities and wellbeing as well as staff members' job satisfaction. Central components of their approach include therapeutic elements such as music and movement in all nursing activities, multidisciplinary collaboration, a broad therapy and social activity offer, the continuation of therapy in everyday activities, a focus on individual life history, values, needs, and skills, social integration into the regional community, and the creation of a meaningful living environment for residents and staff. Conclusion: The BPM we developed shows how a meaningful living environment can be created through therapeutic care and integrative activities. The ToC sheds light onto the contextual factors and cultural values which should be considered in the development of NH interventions. Research on not only biomedical aspects, but also psychosocial dynamics and narrative co-constructions in nursing practice should inform NH innovations. The ToC also highlights the importance of developing adequate political frameworks and infrastructures for implementing such innovative practices on a larger scale. KW - positive gerontology KW - de-institutionalization KW - meaning-making KW - therapeutic emplotment KW - integrated narrative nursing KW - nursing home culture change Y1 - 2022 U6 - https://doi.org/10.1186/s12877-022-03462-0 SN - 1471-2318 VL - 22 IS - 1 PB - BioMed Central CY - London ER - TY - JOUR A1 - Aktas, Berfin A1 - Stede, Manfred T1 - Anaphoric distance in oral and written language BT - Experimental evidence JF - Discours : revue de linguistique, psycholinguistique et informatique N2 - We investigate the variation in oral and written language in terms of anaphoric distance (i.e., the textual distance between anaphors and their antecedents), expanding corpus-based research with experimental evidence. Contrastive corpus studies demonstrate that oral genres include longer average anaphoric distance than written genres, if the distance is measured in terms of clauses (Fox, 1987; Aktas & Stede, 2020). We designed an experiment in order to examine the contrasts in oral and written mediums, using the same genre. We aim to gain more insight about the impact of the medium, in a situation where both mediums convey a similar level of spontaneity, informality and interactivity. We designed a story continuation study, where the participants are recruited via crowdsourcing. To our knowledge, this is the first study of its kind, where anaphoric distance is manipulated systematically in a language production experiment in order to examine medium distinctions. We observed that participants use more pronouns in oral medium than in written medium if the anaphoric distance is long. This result is in line with the implications of the earlier corpus-based research. In addition, our results indicate that anaphoric distance has a larger effect in referential choice for the written medium. KW - anaphora KW - anaphoric distance KW - referential choice KW - production medium KW - oral KW - written KW - story continuation KW - crowdsourcing Y1 - 2022 U6 - https://doi.org/10.4000/discours.12383 SN - 1963-1723 IS - 31 PB - Université de Paris-Sorbonne, Maion Recherche CY - Paris ER - TY - JOUR A1 - Li, Wenjia A1 - Tian, Fang A1 - Rudaya, Natalya A. A1 - Herzschuh, Ulrike A1 - Cao, Xianyong T1 - Pollen-based holocene thawing-history of permafrost in Northern Asia and its potential impacts on climate change JF - Frontiers in Ecology and Evolution N2 - As the recent permafrost thawing of northern Asia proceeds due to anthropogenic climate change, precise and detailed palaeoecological records from past warm periods are essential to anticipate the extent of future permafrost variations. Here, based on the modern relationship between permafrost and vegetation (represented by pollen assemblages), we trained a Random Forest model using pollen and permafrost data and verified its reliability to reconstruct the history of permafrost in northern Asia during the Holocene. An early Holocene (12-8 cal ka BP) strong thawing trend, a middle-to-late Holocene (8-2 cal ka BP) relatively slow thawing trend, and a late Holocene freezing trend of permafrost in northern Asia are consistent with climatic proxies such as summer solar radiation and Northern Hemisphere temperature. The extensive distribution of permafrost in northern Asia inhibited the spread of evergreen coniferous trees during the early Holocene warming and might have decelerated the enhancement of the East Asian summer monsoon (EASM) by altering hydrological processes and albedo. Based on these findings, we suggest that studies of the EASM should consider more the state of permafrost and vegetation in northern Asia, which are often overlooked and may have a profound impact on climate change in this region. KW - pollen KW - Random Forest KW - Siberia KW - East Asian summer monsoon KW - permafrost Y1 - 2022 U6 - https://doi.org/10.3389/fevo.2022.894471 SN - 2296-701X VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Kamali, Bahareh A1 - Lorite, Ignacio J. A1 - Webber, Heidi A. A1 - Rezaei, Ehsan Eyshi A1 - Gabaldon-Leal, Clara A1 - Nendel, Claas A1 - Siebert, Stefan A1 - Ramirez-Cuesta, Juan Miguel A1 - Ewert, Frank A1 - Ojeda, Jonathan J. T1 - Uncertainty in climate change impact studies for irrigated maize cropping systems in southern Spain JF - Scientific reports N2 - This study investigates the main drivers of uncertainties in simulated irrigated maize yield under historical conditions as well as scenarios of increased temperatures and altered irrigation water availability. Using APSIM, MONICA, and SIMPLACE crop models, we quantified the relative contributions of three irrigation water allocation strategies, three sowing dates, and three maize cultivars to the uncertainty in simulated yields. The water allocation strategies were derived from historical records of farmer's allocation patterns in drip-irrigation scheme of the Genil-Cabra region, Spain (2014-2017). By considering combinations of allocation strategies, the adjusted R-2 values (showing the degree of agreement between simulated and observed yields) increased by 29% compared to unrealistic assumptions of considering only near optimal or deficit irrigation scheduling. The factor decomposition analysis based on historic climate showed that irrigation strategies was the main driver of uncertainty in simulated yields (66%). However, under temperature increase scenarios, the contribution of crop model and cultivar choice to uncertainty in simulated yields were as important as irrigation strategy. This was partially due to different model structure in processes related to the temperature responses. Our study calls for including information on irrigation strategies conducted by farmers to reduce the uncertainty in simulated yields at field scale. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-08056-9 SN - 2045-2322 VL - 12 IS - 1 PB - Macmillan Publishers Limited, CY - London ER - TY - JOUR A1 - Ariagno, Coline A1 - Le Bouteiller, Caroline A1 - van der Beek, Pieter A. A1 - Klotz, Sébastien T1 - Sediment export in marly badland catchments modulated by frost-cracking intensity, Draix–Bléone Critical Zone Observatory, SE France JF - Earth surface dynamics : ESURF ; an interactive open access journal of the European Geosciences Union N2 - At the interface between the lithosphere and the atmosphere, the critical zone records the complex interactions between erosion, climate, geologic substrate, and life and can be directly monitored. Long data records (30 consecutive years for sediment yields) collected in the sparsely vegetated, steep, and small marly badland catchments of the Draix-Bleone Critical Zone Observatory (CZO), SE France, allow analyzing potential climatic controls on regolith dynamics and sediment export. Although widely accepted as a first-order control, rainfall variability does not fully explain the observed interannual variability in sediment export. Previous studies in this area have suggested that frost-weathering processes could drive regolith production and potentially modulate the observed pattern of sediment export. Here, we define sediment export anomalies as the residuals from a predictive model with annual rainfall intensity above a threshold as the control. We then use continuous soil temperature data recorded at different locations over multiple years to highlight the role of different frost-weathering processes (i.e., ice segregation versus volumetric expansion) in regolith production. Several proxies for different frost-weathering processes have been calculated from these data and compared to the sediment export anomalies, with careful consideration of field data quality. Our results suggest that frost-cracking intensity (linked to ice segregation) can explain about half (47 %-64 %) of the sediment export anomalies. In contrast, the number of freeze-thaw cycles (linked to volumetric expansion) has only a minor impact on catchment sediment response. The time spent below 0 degrees C also correlates well with the sediment export anomalies and requires fewer field data to be calculated than the frost-cracking intensity. Thus, frost-weathering processes modulate sediment export by controlling regolith production in these catchments and should be taken into account when building predictive models of sediment export from these badlands under a changing climate. Y1 - 2022 U6 - https://doi.org/10.5194/esurf-10-81-2022 SN - 2196-6311 SN - 2196-632X VL - 10 IS - 1 SP - 81 EP - 96 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Peter, Lena A1 - Wendering, Désirée Jacqueline A1 - Schlickeiser, Stephan A1 - Hoffmann, Henrike A1 - Noster, Rebecca A1 - Wagner, Dimitrios Laurin A1 - Zarrinrad, Ghazaleh A1 - Münch, Sandra A1 - Picht, Samira A1 - Schulenberg, Sarah A1 - Moradian, Hanieh A1 - Mashreghi, Mir-Farzin A1 - Klein, Oliver A1 - Gossen, Manfred A1 - Roch, Toralf A1 - Babel, Nina A1 - Reinke, Petra A1 - Volk, Hans-Dieter A1 - Amini, Leila A1 - Schmueck-Henneresse, Michael T1 - Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients JF - Molecular therapy methods and clinical development N2 - Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that compromises their immune response to infections and vaccines. For this reason, SOT patients have a high risk of developing severe coronavirus disease 2019 (COVID-19) and an increased risk of death from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Moreover, the efficiency of immunotherapies and vaccines is reduced due to the constant immunosuppression in this patient group. Here, we propose adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, tacrolimus, for optimized performance in the immunosuppressed patient. Using a ribonucleoprotein approach of CRISPR-Cas9 technology, we have generated tacrolimus-resistant SARS-CoV-2-specific T cell products from convalescent donors and demonstrate their specificity and function through characterizations at the single-cell level, including flow cytometry, single-cell RNA (scRNA) Cellular Indexing of Transcriptomes and Epitopes (CITE), and T cell receptor (TCR) sequencing analyses. Based on the promising results, we aim for clinical validation of this approach in transplant recipients. Additionally, we propose a combinatory approach with tacrolimus, to prevent an overshooting immune response manifested as bystander T cell activation in the setting of severe COVID-19 immunopathology, and tacrolimus-resistant SARS-CoV-2-specific T cell products, allowing for efficient clearance of viral infection. Our strategy has the potential to prevent severe COVID-19 courses in SOT or autoimmunity settings and to prevent immunopathology while providing viral clearance in severe non-transplant COVID-19 cases. Y1 - 2022 U6 - https://doi.org/10.1016/j.omtm.2022.02.012 SN - 2329-0501 VL - 25 SP - 52 EP - 73 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Barcena, Maria Luisa A1 - Aslam, Muhammad A1 - Pozdniakova, Sofya A1 - Norman, Kristina A1 - Ladilov, Yury T1 - Cardiovascular inflammaging: mechanisms and translational aspects JF - Cells N2 - Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging. KW - cardiac inflammaging KW - vascular senescence KW - mitochondrial homeostasis KW - microbiome Y1 - 2022 U6 - https://doi.org/10.3390/cells11061010 SN - 2073-4409 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Fuchs, Matthias A1 - Palmtag, Juri A1 - Juhls, Bennet A1 - Overduin, Pier Paul A1 - Grosse, Guido A1 - Abdelwahab, Ahmed A1 - Bedington, Michael A1 - Sanders, Tina A1 - Ogneva, Olga A1 - Fedorova, Irina A1 - Zimov, Nikita S. A1 - Mann, Paul J. A1 - Strauss, Jens T1 - High-resolution bathymetry models for the Lena Delta and Kolyma Gulf coastal zones JF - Earth system science data N2 - Arctic river deltas and deltaic near-shore zones represent important land-ocean transition zones influencing sediment dynamics and nutrient fluxes from permafrost-affected terrestrial ecosystems into the coastal Arctic Ocean. To accurately model fluvial carbon and freshwater export from rapidly changing river catchments as well as assess impacts of future change on the Arctic shelf and coastal ecosystems, we need to understand the sea floor characteristics and topographic variety of the coastal zones. To date, digital bathymetrical data from the poorly accessible, shallow, and large areas of the eastern Siberian Arctic shelves are sparse. We have digitized bathymetrical information for nearly 75 000 locations from large-scale (1 V 25000-1 V 500000) current and historical nautical maps of the Lena Delta and the Kolyma Gulf region in northeastern Siberia. We present the first detailed and seamless digital models of coastal zone bathymetry for both delta and gulf regions in 50 and 200m spatial resolution. We validated the resulting bathymetry layers using a combination of our own water depth measurements and a collection of available depth measurements, which showed a strong correlation (r>0.9). Our bathymetrical models will serve as an input for a high-resolution coupled hydrodynamic-ecosystem model to better quantify fluvial and coastal carbon fluxes to the Arctic Ocean, but they may be useful for a range of other studies related to Arctic delta and near-shore dynamics such as modeling of submarine permafrost, near-shore sea ice, or shelf sediment transport. The new digital high-resolution bathymetry products are available on the PANGAEA data set repository for the Lena Delta (https://doi.org/10.1594/PANGAEA.934045; Fuchs et al., 2021a) and Kolyma Gulf region (https://doi.org/10.1594/PANGAEA.934049; Fuchs et al., 2021b), respectively. Likewise, the depth validation data are available on PANGAEA as well (https://doi.org/10.1594/PANGAEA.933187; Fuchs et al., 2021c). Y1 - 2022 U6 - https://doi.org/10.5194/essd-14-2279-2022 SN - 1866-3508 SN - 1866-3516 VL - 14 IS - 5 SP - 2279 EP - 2301 PB - Copernicus CY - Göttingen ER - TY - GEN A1 - Cesca, Simone A1 - Stich, Daniel A1 - Grigoli, Francesco A1 - Vuan, Alessandro A1 - López-Comino, José Ángel A1 - Niemz, Peter A1 - Blanch, Estefanía A1 - Dahm, Torsten A1 - Ellsworth, William L. T1 - Reply to: Multiple induced seismicity mechanisms at Castor underground gas storage illustrate the need for thorough monitoring T2 - Nature communications Y1 - 2022 U6 - https://doi.org/10.1038/s41467-022-30904-5 SN - 2041-1723 VL - 13 IS - 1 PB - Nature Research CY - Berlin ER - TY - JOUR A1 - Abdelilah-Seyfried, Salim A1 - Iruela-Arispe, M. Luisa A1 - Penninger, Josef M. A1 - Tournier-Lasserve, Elisabeth A1 - Vikkula, Miikka A1 - Cleaver, Ondine T1 - Recalibrating vascular malformations and mechanotransduction by pharmacological intervention JF - Journal of clinical investigation Y1 - 2022 U6 - https://doi.org/10.1172/JCI160227 SN - 0021-9738 SN - 1558-8238 VL - 132 IS - 8 PB - American Society for Clinical Investigation CY - Ann Arbor ER - TY - JOUR A1 - Li, Jian A1 - Shen, Jinhua A1 - Zhang, Xiaoli A1 - Peng, Yangqin A1 - Zhang, Qin A1 - Hu, Liang A1 - Reichetzeder, Christoph A1 - Zeng, Suimin A1 - Li, Jing A1 - Tian, Mei A1 - Gong, Fei A1 - Lin, Ge A1 - Hocher, Berthold T1 - Risk factors associated with preterm birth after IVF/ICSI JF - Scientific reports N2 - In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd-37th gestational week) and early preterm birth (20th-32nd gestational week). The underlying general and procedure related risk factors are not well understood so far. 4328 infertile women undergoing IVF/ICSI were entered into this study. The study population was divided into three groups: (a) early preterm birth group (n = 66), (b) preterm birth group (n = 675) and (c) full-term birth group (n = 3653). Odds for preterm birth were calculated by stepwise multivariate logistic regression analysis. We identified seven independent risk factors for preterm birth and four independent risk factors for early preterm birth. Older (> 39) or younger (< 25) maternal age (OR: 1.504, 95% CI 1.108-2.042, P = 0.009; OR: 2.125, 95% CI 1.049-4.304, P = 0.036, respectively), multiple pregnancy (OR: 9.780, 95% CI 8.014-11.935, P < 0.001; OR: 8.588, 95% CI 4.866-15.157, P < 0.001, respectively), placenta previa (OR: 14.954, 95% CI 8.053-27.767, P < 0.001; OR: 16.479, 95% CI 4.381-61.976, P < 0.001, respectively), and embryo reduction (OR: 3.547, 95% CI 1.736-7.249, P = 0.001; OR: 7.145, 95% CI 1.990-25.663, P = 0.003, respectively) were associated with preterm birth and early preterm birth, whereas gestational hypertension (OR: 2.494, 95% CI 1.770-3.514, P < 0.001), elevated triglycerides (OR: 1.120, 95% CI 1.011-1.240, P = 0.030) and shorter activated partial thromboplastin time (OR: 0.967, 95% CI 0.949-0.985, P < 0.001) were associated only with preterm birth. In conclusion, preterm and early preterm birth risk factors in patients undergoing assisted IVF/ICSI are in general similar to those in natural pregnancy. The lack of some associations in the early preterm group was most likely due to the lower number of early preterm birth cases. Only embryo reduction represents an IVF/ICSI specific risk factor. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-12149-w SN - 2045-2322 VL - 12 IS - 1 PB - Nature Research CY - Berlin ER - TY - JOUR A1 - Xu, Huizhen A1 - Giannetti, Alessandro A1 - Sugiyama, Yuki A1 - Zheng, Wenna A1 - Schneider, René A1 - Watanabe, Yoichiro A1 - Oda, Yoshihisa A1 - Persson, Staffan T1 - Secondary cell wall patterning-connecting the dots, pits and helices JF - Open biology N2 - All plant cells are encased in primary cell walls that determine plant morphology, but also protect the cells against the environment. Certain cells also produce a secondary wall that supports mechanically demanding processes, such as maintaining plant body stature and water transport inside plants. Both these walls are primarily composed of polysaccharides that are arranged in certain patterns to support cell functions. A key requisite for patterned cell walls is the arrangement of cortical microtubules that may direct the delivery of wall polymers and/or cell wall producing enzymes to certain plasma membrane locations. Microtubules also steer the synthesis of cellulose-the load-bearing structure in cell walls-at the plasma membrane. The organization and behaviour of the microtubule array are thus of fundamental importance to cell wall patterns. These aspects are controlled by the coordinated effort of small GTPases that probably coordinate a Turing's reaction-diffusion mechanism to drive microtubule patterns. Here, we give an overview on how wall patterns form in the water-transporting xylem vessels of plants. We discuss systems that have been used to dissect mechanisms that underpin the xylem wall patterns, emphasizing the VND6 and VND7 inducible systems, and outline challenges that lay ahead in this field. KW - plant cell wall KW - microtubules KW - xylem KW - cell wall patterning KW - cellulose Y1 - 2022 U6 - https://doi.org/10.1098/rsob.210208 SN - 2046-2441 VL - 12 IS - 5 PB - Royal Society CY - London ER - TY - JOUR A1 - Walch, Daniela M. R. A1 - Singh, Rakesh K. A1 - Soreide, Janne E. A1 - Lantuit, Hugues A1 - Poste, Amanda T1 - Spatio-temporal variability of suspended particulate matter in a high-arctic estuary (Adventfjorden, Svalbard) using sentinel-2 time-series JF - Remote sensing N2 - Arctic coasts, which feature land-ocean transport of freshwater, sediments, and other terrestrial material, are impacted by climate change, including increased temperatures, melting glaciers, changes in precipitation and runoff. These trends are assumed to affect productivity in fjordic estuaries. However, the spatial extent and temporal variation of the freshwater-driven darkening of fjords remain unresolved. The present study illustrates the spatio-temporal variability of suspended particulate matter (SPM) in the Adventfjorden estuary, Svalbard, using in-situ field campaigns and ocean colour remote sensing (OCRS) via high-resolution Sentinel-2 imagery. To compute SPM concentration (C-SPMsat), a semi-analytical algorithm was regionally calibrated using local in-situ data, which improved the accuracy of satellite-derived SPM concentration by similar to 20% (MRD). Analysis of SPM concentration for two consecutive years (2019, 2020) revealed strong seasonality of SPM in Adventfjorden. Highest estimated SPM concentrations and river plume extent (% of fjord with C-SPMsat > 30 mg L-1) occurred during June, July, and August. Concurrently, we observed a strong relationship between river plume extent and average air temperature over the 24 h prior to the observation (R-2 = 0.69). Considering predicted changes to environmental conditions in the Arctic region, this study highlights the importance of the rapidly changing environmental parameters and the significance of remote sensing in analysing fluxes in light attenuating particles, especially in the coastal Arctic Ocean. KW - ocean colour KW - coastal darkening KW - SPM KW - sediment plumes KW - Arctic coast KW - remote sensing KW - regional tuning KW - coastal ecosystems; KW - land-ocean-interaction KW - riverine inputs Y1 - 2022 U6 - https://doi.org/10.3390/rs14133123 SN - 2072-4292 VL - 14 IS - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kaa, Johannes M. A1 - Sternemann, Christian A1 - Appel, Karen A1 - Cerantola, Valerio A1 - Preston, Thomas R. A1 - Albers, Christian A1 - Elbers, Mirko A1 - Libon, Lelia A1 - Makita, Mikako A1 - Pelka, Alexander A1 - Petitgirard, Sylvain A1 - Plückthun, Christian A1 - Roddatis, Vladimir A1 - Sahle, Christoph J. A1 - Spiekermann, Georg A1 - Schmidt, Christian A1 - Schreiber, Anja A1 - Sakrowski, Robin A1 - Tolan, Metin A1 - Wilke, Max A1 - Zastrau, Ulf A1 - Konopkova, Zuzana T1 - Structural and electron spin state changes in an x-ray heated iron carbonate system at the Earth's lower mantle pressures JF - Physical review research N2 - The determination of the spin state of iron-bearing compounds at high pressure and temperature is crucial for our understanding of chemical and physical properties of the deep Earth. Studies on the relationship between the coordination of iron and its electronic spin structure in iron-bearing oxides, silicates, carbonates, iron alloys, and other minerals found in the Earth's mantle and core are scarce because of the technical challenges to simultaneously probe the sample at high pressures and temperatures. We used the unique properties of a pulsed and highly brilliant x-ray free electron laser (XFEL) beam at the High Energy Density (HED) instrument of the European XFEL to x-ray heat and probe samples contained in a diamond anvil cell. We heated and probed with the same x-ray pulse train and simultaneously measured x-ray emission and x-ray diffraction of an FeCO3 sample at a pressure of 51 GPa with up to melting temperatures. We collected spin state sensitive Fe K beta(1,3) fluorescence spectra and detected the sample's structural changes via diffraction, observing the inverse volume collapse across the spin transition. During x-ray heating, the carbonate transforms into orthorhombic Fe4C3O12 and iron oxides. Incipient melting was also observed. This approach to collect information about the electronic state and structural changes from samples contained in a diamond anvil cell at melting temperatures and above will considerably improve our understanding of the structure and dynamics of planetary and exoplanetary interiors. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevResearch.4.033042 SN - 2643-1564 VL - 4 IS - 3 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Agne, Stefanie A1 - Naylor, Gavin J. P. A1 - Preick, Michaela A1 - Yang, Lei A1 - Thiel, Ralf A1 - Weigmann, Simon A1 - Paijmans, Johanna L. A. A1 - Barlow, Axel A1 - Hofreiter, Michael A1 - Straube, Nicolas T1 - Taxonomic identification of two poorly known lantern shark species based on mitochondrial DNA from wet-collection paratypes JF - Frontiers in Ecology and Evolution N2 - Etmopteridae (lantern sharks) is the most species-rich family of sharks, comprising more than 50 species. Many species are described from few individuals, and re-collection of specimens is often hindered by the remoteness of their sampling sites. For taxonomic studies, comparative morphological analysis of type specimens housed in natural history collections has been the main source of evidence. In contrast, DNA sequence information has rarely been used. Most lantern shark collection specimens, including the types, were formalin fixed before long-term storage in ethanol solutions. The DNA damage caused by both fixation and preservation of specimens has excluded these specimens from DNA sequence-based phylogenetic analyses so far. However, recent advances in the field of ancient DNA have allowed recovery of wet-collection specimen DNA sequence data. Here we analyse archival mitochondrial DNA sequences, obtained using ancient DNA approaches, of two wet-collection lantern shark paratype specimens, namely Etmopterus litvinovi and E. pycnolepis, for which the type series represent the only known individuals. Target capture of mitochondrial markers from single-stranded DNA libraries allows for phylogenetic placement of both species. Our results suggest synonymy of E. benchleyi with E. litvinovi but support the species status of E. pycnolepis. This revised taxonomy is helpful for future conservation and management efforts, as our results indicate a larger distribution range of E. litvinovi. This study further demonstrates the importance of wet-collection type specimens as genetic resource for taxonomic research. KW - type specimens KW - Etmopterus litvinovi KW - Etmopterus pycnolepis KW - deep-sea KW - sharks KW - archival DNA Y1 - 2022 U6 - https://doi.org/10.3389/fevo.2022.910009 SN - 2296-701X VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Zeitz, Maria A1 - Haacker, Jan M. A1 - Donges, Jonathan A1 - Albrecht, Torsten A1 - Winkelmann, Ricarda T1 - Dynamic regimes of the Greenland Ice Sheet emerging from interacting melt-elevation and glacial isostatic adjustment feedbacks JF - Earth system dynamics N2 - The stability of the Greenland Ice Sheet under global warming is governed by a number of dynamic processes and interacting feedback mechanisms in the ice sheet, atmosphere and solid Earth. Here we study the long-term effects due to the interplay of the competing melt-elevation and glacial isostatic adjustment (GIA) feedbacks for different temperature step forcing experiments with a coupled ice-sheet and solid-Earth model. Our model results show that for warming levels above 2 degrees C, Greenland could become essentially ice-free within several millennia, mainly as a result of surface melting and acceleration of ice flow. These ice losses are mitigated, however, in some cases with strong GIA feedback even promoting an incomplete recovery of the Greenland ice volume. We further explore the full-factorial parameter space determining the relative strengths of the two feedbacks: our findings suggest distinct dynamic regimes of the Greenland Ice Sheets on the route to destabilization under global warming - from incomplete recovery, via quasi-periodic oscillations in ice volume to ice-sheet collapse. In the incomplete recovery regime, the initial ice loss due to warming is essentially reversed within 50 000 years, and the ice volume stabilizes at 61 %-93 % of the present-day volume. For certain combinations of temperature increase, atmospheric lapse rate and mantle viscosity, the interaction of the GIA feedback and the melt-elevation feedback leads to self-sustained, long-term oscillations in ice-sheet volume with oscillation periods between 74 000 and over 300 000 years and oscillation amplitudes between 15 %-70 % of present-day ice volume. This oscillatory regime reveals a possible mode of internal climatic variability in the Earth system on timescales on the order of 100 000 years that may be excited by or synchronized with orbital forcing or interact with glacial cycles and other slow modes of variability. Our findings are not meant as scenario-based near-term projections of ice losses but rather providing insight into of the feedback loops governing the "deep future" and, thus, long-term resilience of the Greenland Ice Sheet. Y1 - 2022 U6 - https://doi.org/10.5194/esd-13-1077-2022 SN - 2190-4979 SN - 2190-4987 VL - 13 IS - 3 SP - 1077 EP - 1096 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Schlemm, Tanja A1 - Feldmann, Johannes A1 - Winkelmann, Ricarda A1 - Levermann, Anders T1 - Stabilizing effect of melange buttressing on the marine ice-cliff instability of the West Antarctic Ice Sheet JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Owing to global warming and particularly high regional ocean warming, both Thwaites and Pine Island Glaciers in the Amundsen region of the Antarctic Ice Sheet could lose their buttressing ice shelves over time. We analyse the possible consequences using the parallel ice sheet model (PISM), applying a simple cliff-calving parameterization and an ice melange-buttressing model. We find that the instantaneous loss of ice-shelf buttressing, due to enforced ice-shelf melting, initiates grounding-line retreat and triggers marine ice sheet instability (MISI). As a consequence, the grounding line progresses into the interior of the West Antarctic Ice Sheet and leads to a sea level contribution of 0.6 m within 100 a. By subjecting the exposed ice cliffs to cliff calving using our simplified parameterization, we also analyse marine ice cliff instability (MICI). In our simulations it can double or even triple the sea level contribution depending on the only loosely constrained parameter that determines the maximum cliff-calving rate. The speed of MICI depends on this upper bound of the calving rate, which is given by the ice melange buttressing the glacier. However, stabilization of MICI may occur for geometric reasons. Because the embayment geometry changes as MICI advances into the interior of the ice sheet, the upper bound on calving rates is reduced and the progress of MICI is slowed down. Although we cannot claim that our simulations bear relevant quantitative estimates of the effect of ice-melange buttressing on MICI, the mechanism has the potential to stop the instability. Further research is needed to evaluate its role for the past and future evolution of the Antarctic Ice Sheet. Y1 - 2022 U6 - https://doi.org/10.5194/tc-16-1979-2022 SN - 1994-0416 SN - 1994-0424 VL - 16 IS - 5 SP - 1979 EP - 1996 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Feldmann, Johannes A1 - Reese, Ronja A1 - Winkelmann, Ricarda A1 - Levermann, Anders T1 - Shear-margin melting causes stronger transient ice discharge than ice-stream melting in idealized simulations JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Basal ice-shelf melting is the key driver of Antarctica's increasing sea-level contribution. In diminishing the buttressing force of the ice shelves that fringe the ice sheet, the melting increases the ice discharge into the ocean. Here we contrast the influence of basal melting in two different ice-shelf regions on the time-dependent response of an isothermal, inherently buttressed ice-sheet-shelf system. In the idealized numerical simulations, the basal-melt perturbations are applied close to the grounding line in the ice-shelf's (1) ice-stream region, where the ice shelf is fed by the fastest ice masses that stream through the upstream bed trough and (2) shear margins, where the ice flow is slower. The results show that melting below one or both of the shear margins can cause a decadal to centennial increase in ice discharge that is more than twice as large compared to a similar perturbation in the ice-stream region. We attribute this to the fact that melt-induced ice-shelf thinning in the central grounding-line region is attenuated very effectively by the fast flow of the central ice stream. In contrast, the much slower ice dynamics in the lateral shear margins of the ice shelf facilitate sustained ice-shelf thinning and thereby foster buttressing reduction. Regardless of the melt location, a higher melt concentration toward the grounding line generally goes along with a stronger response. Our results highlight the vulnerability of outlet glaciers to basal melting in stagnant, buttressing-relevant ice-shelf regions, a mechanism that may gain importance under future global warming. Y1 - 2022 U6 - https://doi.org/10.5194/tc-16-1927-2022 SN - 1994-0416 SN - 1994-0424 VL - 16 IS - 5 SP - 1927 EP - 1940 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Durand, Gael A1 - van den Broeke, Michiel R. A1 - Le Cozannet, Goneri A1 - Edwards, Tamsin L. A1 - Holland, Paul R. A1 - Jourdain, Nicolas C. A1 - Marzeion, Ben A1 - Mottram, Ruth A1 - Nicholls, Robert J. A1 - Pattyn, Frank A1 - Paul, Frank A1 - Slangen, Aimee B. A. A1 - Winkelmann, Ricarda A1 - Burgard, Clara A1 - van Calcar, Caroline J. A1 - Barre, Jean-Baptiste A1 - Bataille, Amelie A1 - Chapuis, Anne T1 - Sea-Level rise: from global perspectives to local services JF - Frontiers in Marine Science N2 - Coastal areas are highly diverse, ecologically rich, regions of key socio-economic activity, and are particularly sensitive to sea-level change. Over most of the 20th century, global mean sea level has risen mainly due to warming and subsequent expansion of the upper ocean layers as well as the melting of glaciers and ice caps. Over the last three decades, increased mass loss of the Greenland and Antarctic ice sheets has also started to contribute significantly to contemporary sea-level rise. The future mass loss of the two ice sheets, which combined represent a sea-level rise potential of similar to 65 m, constitutes the main source of uncertainty in long-term (centennial to millennial) sea-level rise projections. Improved knowledge of the magnitude and rate of future sea-level change is therefore of utmost importance. Moreover, sea level does not change uniformly across the globe and can differ greatly at both regional and local scales. The most appropriate and feasible sea level mitigation and adaptation measures in coastal regions strongly depend on local land use and associated risk aversion. Here, we advocate that addressing the problem of future sea-level rise and its impacts requires (i) bringing together a transdisciplinary scientific community, from climate and cryospheric scientists to coastal impact specialists, and (ii) interacting closely and iteratively with users and local stakeholders to co-design and co-build coastal climate services, including addressing the high-end risks. KW - sea-level rise KW - Antarctic KW - Greenland KW - glaciers KW - local impact Y1 - 2022 U6 - https://doi.org/10.3389/fmars.2021.709595 SN - 2296-7745 VL - 8 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Bulla, Mattia A1 - Coughlin, Michael W. A1 - Dhawan, Suhail A1 - Dietrich, Tim T1 - Multi-messenger constraints on the Hubble constant through combination of gravitational waves, gamma-ray bursts and kilonovae from neutron star mergers JF - Universe : open access journal N2 - The simultaneous detection of gravitational waves and light from the binary neutron star merger GW170817 led to independent measurements of distance and redshift, providing a direct estimate of the Hubble constant H-0 that does not rely on a cosmic distance ladder, nor assumes a specific cosmological model. By using gravitational waves as "standard sirens", this approach holds promise to arbitrate the existing tension between the H-0 value inferred from the cosmic microwave background and those obtained from local measurements. However, the known degeneracy in the gravitational-wave analysis between distance and inclination of the source led to a H-0 value from GW170817 that was not precise enough to resolve the existing tension. In this review, we summarize recent works exploiting the viewing-angle dependence of the electromagnetic signal, namely the associated short gamma-ray burst and kilonova, to constrain the system inclination and improve on H-0. We outline the key ingredients of the different methods, summarize the results obtained in the aftermath of GW170817 and discuss the possible systematics introduced by each of these methods. KW - gravitational waves KW - stars: neutron KW - stars: binaries KW - cosmology: cosmological parameters KW - cosmology: distance scale KW - cosmology: cosmic background radiation Y1 - 2022 U6 - https://doi.org/10.3390/universe8050289 SN - 2218-1997 VL - 8 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Lehmann, Nico A1 - Kuhn, Yves-Alain A1 - Keller, Martin A1 - Aye, Norman A1 - Herold, Fabian A1 - Draganski, Bogdan A1 - Taube, Wolfgang A1 - Taubert, Marco T1 - Brain activation during active balancing and its behavioral relevance in younger and older adults BT - a functional near-infrared spectroscopy (fNIRS) study JF - Frontiers in Aging Neuroscience N2 - Age-related deterioration of balance control is widely regarded as an important phenomenon influencing quality of life and longevity, such that a more comprehensive understanding of the neural mechanisms underlying this process is warranted. Specifically, previous studies have reported that older adults typically show higher neural activity during balancing as compared to younger counterparts, but the implications of this finding on balance performance remain largely unclear. Using functional near-infrared spectroscopy (fNIRS), differences in the cortical control of balance between healthy younger (n = 27) and older (n = 35) adults were explored. More specifically, the association between cortical functional activity and balance performance across and within age groups was investigated. To this end, we measured hemodynamic responses (i.e., changes in oxygenated and deoxygenated hemoglobin) while participants balanced on an unstable device. As criterion variables for brain-behavior-correlations, we also assessed postural sway while standing on a free-swinging platform and while balancing on wobble boards with different levels of difficulty. We found that older compared to younger participants had higher activity in prefrontal and lower activity in postcentral regions. Subsequent robust regression analyses revealed that lower prefrontal brain activity was related to improved balance performance across age groups, indicating that higher activity of the prefrontal cortex during balancing reflects neural inefficiency. We also present evidence supporting that age serves as a moderator in the relationship between brain activity and balance, i.e., cortical hemodynamics generally appears to be a more important predictor of balance performance in the older than in the younger. Strikingly, we found that age differences in balance performance are mediated by balancing-induced activation of the superior frontal gyrus, thus suggesting that differential activation of this region reflects a mechanism involved in the aging process of the neural control of balance. Our study suggests that differences in functional brain activity between age groups are not a mere by-product of aging, but instead of direct behavioral relevance for balance performance. Potential implications of these findings in terms of early detection of fall-prone individuals and intervention strategies targeting balance and healthy aging are discussed. KW - aging KW - neuroimaging KW - functional near-infrared spectroscopy (fNIRS) KW - balance KW - postural control KW - prefrontal cortex KW - neural inefficiency Y1 - 2022 U6 - https://doi.org/10.3389/fnagi.2022.828474 SN - 1663-4365 VL - 14 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Konigorski, Stefan A1 - Wernicke, Sarah A1 - Slosarek, Tamara A1 - Zenner, Alexander M. A1 - Strelow, Nils A1 - Ruether, Darius F. A1 - Henschel, Florian A1 - Manaswini, Manisha A1 - Pottbäcker, Fabian A1 - Edelman, Jonathan A. A1 - Owoyele, Babajide A1 - Danieletto, Matteo A1 - Golden, Eddye A1 - Zweig, Micol A1 - Nadkarni, Girish N. A1 - Böttinger, Erwin T1 - StudyU: a platform for designing and conducting innovative digital N-of-1 trials JF - Journal of medical internet research N2 - N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully functional platforms are not yet available. Here, we present the open source StudyU platform, which includes the StudyU Designer and StudyU app. With the StudyU Designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials. The StudyU app is a smartphone app with innovative user-centric elements for participants to partake in trials published through the StudyU Designer to assess the effects of different interventions on their health. Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner. We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice. KW - digital interventions KW - N-of-1 trial KW - SCED KW - single-case experimental design KW - web application KW - mobile application KW - app KW - digital health Y1 - 2022 U6 - https://doi.org/10.2196/35884 SN - 1439-4456 SN - 1438-8871 VL - 24 IS - 7 PB - Healthcare World CY - Richmond, Va. ER - TY - JOUR A1 - Toumoulin, Agathe A1 - Tardif-Becquet, Delphine A1 - Donnadieu, Yannick A1 - Licht, Alexis A1 - Ladant, Jean-Baptiste A1 - Kunzmann, Lutz A1 - Dupont-Nivet, Guillaume T1 - Evolution of continental temperature seasonality from the Eocene greenhouse to the Oligocene icehouse BT - a model-data comparison JF - Climate of the past : an interactive open access journal of the European Geosciences Union N2 - At the junction of greenhouse and icehouse climate states, the Eocene-Oligocene Transition (EOT) is a key moment in Cenozoic climate history. While it is associated with severe extinctions and biodiversity turnovers on land, the role of terrestrial climate evolution remains poorly resolved, especially the associated changes in seasonality. Some paleobotanical and geochemical continental records in parts of the Northern Hemisphere suggest the EOT is associated with a marked cooling in winter, leading to the development of more pronounced seasons (i.e., an increase in the mean annual range of temperature, MATR). However, the MATR increase has been barely studied by climate models and large uncertainties remain on its origin, geographical extent and impact. In order to better understand and describe temperature seasonality changes between the middle Eocene and the early Oligocene, we use the Earth system model IPSL-CM5A2 and a set of simulations reconstructing the EOT through three major climate forcings: pCO(2) decrease (1120, 840 and 560 ppm), the Antarctic ice-sheet (AIS) formation and the associated sea-level decrease. Our simulations suggest that pCO(2) lowering alone is not sufficient to explain the seasonality evolution described by the data through the EOT but rather that the combined effects of pCO(2) , AIS formation and increased continentality provide the best data-model agreement.pCO(2) decrease induces a zonal pattern with alternating increasing and decreasing seasonality bands particularly strong in the northern high latitudes (up to 8 degrees C MATR increase) due to sea-ice and surface albedo feedback. Conversely, the onset of the AIS is responsible for a more constant surface albedo yearly, which leads to a strong decrease in seasonality in the southern midlatitudes to high latitudes (> 40 degrees S). Finally, continental areas that emerged due to the sea-level lowering cause the largest increase in seasonality and explain most of the global heterogeneity in MATR changes (1MATR) patterns. The Delta MATR patterns we reconstruct are generally consistent with the variability of the EOT biotic crisis intensity across the Northern Hemisphere and provide insights on their underlying mechanisms. Y1 - 2022 U6 - https://doi.org/10.5194/cp-18-341-2022 SN - 1814-9324 SN - 1814-9332 VL - 18 IS - 2 SP - 341 EP - 362 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Herrmann, Matthias L. A1 - Boden, Cindy A1 - Maurer, Christoph A1 - Kentischer, Felix A1 - Mennig, Eva A1 - Wagner, Sören A1 - Conzelmann, Lars O. A1 - Förstner, Bernd R. A1 - Rapp, Michael A. A1 - von Arnim, Christine A. F. A1 - Denkinger, Michael A1 - Eschweiler, Gerhard W. A1 - Thomas, Christine T1 - Anticholinergic drug exposure increases the risk of delirium in older patients undergoing elective surgery JF - Frontiers in medicine N2 - IntroductionPostoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful. Although preoperative medication intake is assumed to be an important modifiable risk factor, the impact of anticholinergic drugs on the occurrence of POD seems underestimated in elective surgery. The aim of this study was to investigate the association between preoperative anticholinergic burden and POD. We hypothesized that a high preoperative anticholinergic burden is an independent, potentially modifiable predisposing and precipitating factor of POD in older people. MethodsBetween November 2017 and April 2019, 1,470 patients of 70 years and older undergoing elective orthopedic, general, cardiac, or vascular surgery were recruited in the randomized, prospective, multicenter PAWEL trial. Anticholinergic burden of a sub-cohort of 899 patients, who did not receive a multimodal intervention for preventing POD, was assessed by two different tools at hospital admission: The established Anticholinergic Risk Scale (ARS) and the recently developed Anticholinergic Burden Score (ABS). POD was detected by confusion assessment method (CAM) and a validated post discharge medical record review. Logistic regression analyses were performed to evaluate the association between anticholinergic burden and POD. ResultsPOD was observed in 210 of 899 patients (23.4%). Both ARS and ABS were independently associated with POD. The association persisted after adjustment for relevant confounding factors such as age, sex, comorbidities, preoperative cognitive and physical status, number of prescribed drugs, surgery time, type of surgery and anesthesia, usage of heart-lung-machine, and treatment in intensive care unit. If a patient was taking one of the 56 drugs listed in the ABS, risk for POD was 2.7-fold higher (OR = 2.74, 95% CI = 1.55-4.94) and 1.5-fold higher per additional point on the ARS (OR = 1.54, 95% CI = 1.15-2.02). ConclusionPreoperative anticholinergic drug exposure measured by ARS or ABS was independently associated with POD in older patients undergoing elective surgery. Therefore, identification, discontinuation or substitution of anticholinergic medication prior to surgery may be a promising approach to reduce the risk of POD in older patients. KW - delirium KW - acute encephalopathy KW - surgery KW - anticholinergic KW - geriatric KW - postoperative Y1 - 2022 U6 - https://doi.org/10.3389/fmed.2022.871229 SN - 2296-858X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Haugk, Charlotte A1 - Jongejans, Loeka L. A1 - Mangelsdorf, Kai A1 - Fuchs, Matthias A1 - Ogneva, Olga A1 - Palmtag, Juri A1 - Mollenhauer, Gesine A1 - Mann, Paul J. A1 - Overduin, P. Paul A1 - Grosse, Guido A1 - Sanders, Tina A1 - Tuerena, Robyn E. A1 - Schirrmeister, Lutz A1 - Wetterich, Sebastian A1 - Kizyakov, Alexander A1 - Karger, Cornelia A1 - Strauss, Jens T1 - Organic matter characteristics of a rapidly eroding permafrost cliff in NE Siberia (Lena Delta, Laptev Sea region) JF - Biogeosciences N2 - Organic carbon (OC) stored in Arctic permafrost represents one of Earth's largest and most vulnerable terrestrial carbon pools. Amplified climate warming across the Arctic results in widespread permafrost thaw. Permafrost deposits exposed at river cliffs and coasts are particularly susceptible to thawing processes. Accelerating erosion of terrestrial permafrost along shorelines leads to increased transfer of organic matter (OM) to nearshore waters. However, the amount of terrestrial permafrost carbon and nitrogen as well as the OM quality in these deposits is still poorly quantified. We define the OM quality as the intrinsic potential for further transformation, decomposition and mineralisation. Here, we characterise the sources and the quality of OM supplied to the Lena River at a rapidly eroding permafrost river shoreline cliff in the eastern part of the delta (Sobo-Sise Island). Our multi-proxy approach captures bulk elemental, molecu- lar geochemical and carbon isotopic analyses of Late Pleistocene Yedoma permafrost and Holocene cover deposits, discontinuously spanning the last similar to 52 kyr. We showed that the ancient permafrost exposed in the Sobo-Sise cliff has a high organic carbon content (mean of about 5 wt %). The oldest sediments stem from Marine Isotope Stage (MIS) 3 interstadial deposits (dated to 52 to 28 cal ka BP) and are overlaid by last glacial MIS 2 (dated to 28 to 15 cal ka BP) and Holocene MIS 1 (dated to 7-0 cal ka BP) deposits. The relatively high average chain length (ACL) index of n-alkanes along the cliff profile indicates a predominant contribution of vascular plants to the OM composition. The elevated ratio of isoand anteiso-branched fatty acids (FAs) relative to mid- and long-chain (C >= 20) n-FAs in the interstadial MIS 3 and the interglacial MIS 1 deposits suggests stronger microbial activity and consequently higher input of bacterial biomass during these climatically warmer periods. The overall high carbon preference index (CPI) and higher plant fatty acid (HPFA) values as well as high C/N ratios point to a good quality of the preserved OM and thus to a high potential of the OM for decomposition upon thaw. A decrease in HPFA values downwards along the profile probably indicates stronger OM decomposition in the oldest (MIS 3) deposits of the cliff. The characterisation of OM from eroding permafrost leads to a better assessment of the greenhouse gas potential of the OC released into river and nearshore waters in the future. Y1 - 2022 U6 - https://doi.org/10.5194/bg-19-2079-2022 SN - 1726-4170 SN - 1726-4189 VL - 19 IS - 7 SP - 2079 EP - 2094 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Voglimacci-Stephanopoli, Joëlle A1 - Wendleder, Anna A1 - Lantuit, Hugues A1 - Langlois, Alexandre A1 - Stettner, Samuel A1 - Schmitt, Andreas A1 - Dedieu, Jean-Pierre A1 - Roth, Achim A1 - Royer, Alain T1 - Potential of X-band polarimetric synthetic aperture radar co-polar phase difference for arctic snow depth estimation JF - Cryosphere N2 - Changes in snowpack associated with climatic warming has drastic impacts on surface energy balance in the cryosphere. Yet, traditional monitoring techniques, such as punctual measurements in the field, do not cover the full snowpack spatial and temporal variability, which hampers efforts to upscale measurements to the global scale. This variability is one of the primary constraints in model development. In terms of spatial resolution, active microwaves (synthetic aperture radar - SAR) can address the issue and outperform methods based on passive microwaves. Thus, high-spatial-resolution monitoring of snow depth (SD) would allow for better parameterization of local processes that drive the spatial variability of snow. The overall objective of this study is to evaluate the potential of the TerraSAR-X (TSX) SAR sensor and the wave co-polar phase difference (CPD) method for characterizing snow cover at high spatial resolution. Consequently, we first (1) investigate SD and depth hoar fraction (DHF) variability between different vegetation classes in the Ice Creek catchment (Qikiqtaruk/Herschel Island, Yukon, Canada) using in situ measurements collected over the course of a field campaign in 2019; (2) evaluate linkages between snow characteristics and CPD distribution over the 2019 dataset; and (3) determine CPD seasonality considering meteorological data over the 2015-2019 period. SD could be extracted using the CPD when certain conditions are met. A high incidence angle (>30 circle) with a high topographic wetness index (TWI) (>7.0) showed correlation between SD and CPD (R2 up to 0.72). Further, future work should address a threshold of sensitivity to TWI and incidence angle to map snow depth in such environments and assess the potential of using interpolation tools to fill in gaps in SD information on drier vegetation types. Y1 - 2022 U6 - https://doi.org/10.5194/tc-16-2163-2022 SN - 1994-0416 SN - 1994-0424 VL - 16 IS - 6 SP - 2163 EP - 2181 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Xiong, Yingquan A1 - Delic, Denis A1 - Zeng, Shufei A1 - Chen, Xin A1 - Chu, Chang A1 - Hasan, Ahmed A. A1 - Krämer, Bernhard K. A1 - Klein, Thomas A1 - Yin, Lianghong A1 - Hocher, Berthold T1 - Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker JF - BMC nephrology N2 - Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocking agents can be safely used during a SARS-CoV-2 infection but it is unknown if DPP-4 inhibitors or SGLT2-blockers may promote COVID-19 by increasing the host viral entry enzymes ACE2 and TMPRSS2. Methods We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model. In the present study, the gene expression of Ace2, Tmprss2, Ren, Agtr2 and Agt was assessed with qRT-PCR and the protein expression of ACE2 and TMPRSS2 with immunohistochemistry in the following experimental groups: Sham + normal diet (ND) + placebo (PBO); 5/6Nx + ND + PBO; 5/6Nx + high salt-diet (HSD) + PBO; 5/6Nx + HSD + telmisartan; 5/6Nx + HSD + linagliptin; 5/6Nx + HSD + empagliflozin. Results In the kidney, the expression of Ace2 was not altered on mRNA level under disease and treatment conditions. The renal TMPRSS2 levels (mRNA and protein) were not affected, whereas the cardiac level was significantly increased in 5/6Nx rats. Intriguingly, the elevated TMPRSS2 protein expression in the heart was significantly normalized after treatment with telmisartan, linagliptin and empagliflozin. Conclusions Our study indicated that there is no upregulation regarding host factors potentially promoting SARS-CoV-2 virus entry into host cells when the SGLT2-blocker empagliflozin, telmisartan and the DPP4-inhibitor blocker linagliptin are used. The results obtained in a preclinical, experimental non-diabetic kidney failure model need confirmation in ongoing interventional clinical trials. KW - SARS CoV-2 host factors KW - 5/6 nephrectomy KW - High-salt diet KW - ARB KW - DPP4 inhibitor KW - SGLT2 blocker Y1 - 2022 U6 - https://doi.org/10.1186/s12882-022-02747-1 SN - 1471-2369 VL - 23 IS - 1 PB - Springer Nature CY - London ER - TY - JOUR A1 - Shams, Boshra A1 - Wang, Ziqian A1 - Roine, Timo A1 - Aydogan, Dogu Baran A1 - Vajkoczy, Peter A1 - Lippert, Christoph A1 - Picht, Thomas A1 - Fekonja, Lucius Samo T1 - Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract JF - Brain communications N2 - Shams et al. report that glioma patients' motor status is predicted accurately by diffusion MRI metrics along the corticospinal tract based on support vector machine method, reaching an overall accuracy of 77%. They show that these metrics are more effective than demographic and clinical variables. Along tract statistics enables white matter characterization using various diffusion MRI metrics. These diffusion models reveal detailed insights into white matter microstructural changes with development, pathology and function. Here, we aim at assessing the clinical utility of diffusion MRI metrics along the corticospinal tract, investigating whether motor glioma patients can be classified with respect to their motor status. We retrospectively included 116 brain tumour patients suffering from either left or right supratentorial, unilateral World Health Organization Grades II, III and IV gliomas with a mean age of 53.51 +/- 16.32 years. Around 37% of patients presented with preoperative motor function deficits according to the Medical Research Council scale. At group level comparison, the highest non-overlapping diffusion MRI differences were detected in the superior portion of the tracts' profiles. Fractional anisotropy and fibre density decrease, apparent diffusion coefficient axial diffusivity and radial diffusivity increase. To predict motor deficits, we developed a method based on a support vector machine using histogram-based features of diffusion MRI tract profiles (e.g. mean, standard deviation, kurtosis and skewness), following a recursive feature elimination method. Our model achieved high performance (74% sensitivity, 75% specificity, 74% overall accuracy and 77% area under the curve). We found that apparent diffusion coefficient, fractional anisotropy and radial diffusivity contributed more than other features to the model. Incorporating the patient demographics and clinical features such as age, tumour World Health Organization grade, tumour location, gender and resting motor threshold did not affect the model's performance, revealing that these features were not as effective as microstructural measures. These results shed light on the potential patterns of tumour-related microstructural white matter changes in the prediction of functional deficits. KW - machine learning KW - support vector machine KW - tractography KW - diffusion MRI; KW - corticospinal tract Y1 - 2022 U6 - https://doi.org/10.1093/braincomms/fcac141 SN - 2632-1297 VL - 4 IS - 3 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Kaya, Mustafa Yücel A1 - Dupont-Nivet, Guillaume A1 - Frieling, Joost A1 - Fioroni, Chiara A1 - Rohrmann, Alexander A1 - Altıner, Sevinç Özkan A1 - Vardar, Ezgi A1 - Tanyas, Hakan A1 - Mamtimin, Mehmut A1 - Zhaojie, Guo T1 - The Eurasian epicontinental sea was an important carbon sink during the Palaeocene-Eocene thermal maximum JF - Communications earth and environment N2 - The Palaeocene-Eocene Thermal Maximum (ca. 56 million years ago) offers a primary analogue for future global warming and carbon cycle recovery. Yet, where and how massive carbon emissions were mitigated during this climate warming event remains largely unknown. Here we show that organic carbon burial in the vast epicontinental seaways that extended over Eurasia provided a major carbon sink during the Palaeocene-Eocene Thermal Maximum. We coupled new and existing stratigraphic analyses to a detailed paleogeographic framework and using spatiotemporal interpolation calculated ca. 720–1300 Gt organic carbon excess burial, focused in the eastern parts of the Eurasian epicontinental seaways. A much larger amount (2160–3900 Gt C, and when accounting for the increase in inundated shelf area 7400–10300 Gt C) could have been sequestered in similar environments globally. With the disappearance of most epicontinental seas since the Oligocene-Miocene, an effective negative carbon cycle feedback also disappeared making the modern carbon cycle critically dependent on the slower silicate weathering feedback. Y1 - 2022 U6 - https://doi.org/10.1038/s43247-022-00451-4 SN - 2662-4435 VL - 3 IS - 1 PB - Springer Nature CY - London ER - TY - JOUR A1 - Özsoy, Onur A1 - Iefremenko, Kateryna A1 - Schroeder, Christoph T1 - Shifting and expanding clause combining strategies in heritage Turkish varieties JF - Languages N2 - Turkish is a language described as relying predominantly on non-finite subordination in the domain of clause combining. However, there are also strategies of finite subordination, as well as means of syndetic and asyndetic paratactic clause combining, especially in the informal settings. Clause combining is and has been one of the focal points of research on heritage Turkish (h-Turkish). One point is particularly clear: In comparison with the monolingual setting, finite means of clause combining are more frequent in h-Turkish in Germany, the U.S., and the Netherlands, while non-finite means of clause combining are less frequent. Overall, our results confirm the findings of earlier studies: heritage speakers in Germany and the U.S. prefer paratactic means of clause combining using connectors, as opposed to monolingual speakers. Our results also reveal that age (adolescents vs. adults) and register (informal vs. formal) significantly modulate the use of connectors. Moreover, we find that the shift in preferences in means of clause combining triggers an expansion in the system of connectors and leads to the development of new narrative connectors, such as o zaman and derken. The system of syndetic paratactic clause combining is expanding in heritage Turkish. This expansion calls for multifaceted modeling of change in heritage languages, which integrates language-internal factors (register), dynamics of convergence with the contact languages, and extra-linguistic factors (age and language use). KW - bilingualism KW - corpus linguistics KW - heritage languages KW - heritage Turkish KW - clause combining KW - coordination KW - connectors Y1 - 2022 U6 - https://doi.org/10.3390/languages7030242 SN - 2226-471X VL - 7 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wendering, Philipp A1 - Nikoloski, Zoran T1 - Genome-scale modeling specifies the metabolic capabilities of Rhizophagus irregularis JF - mSystems N2 - Rhizophagus irregularis is one of the most extensively studied arbuscular mycorrhizal fungi (AMF) that forms symbioses with and improves the performance of many crops. Lack of transformation protocol for R. irregularis renders it challenging to investigate molecular mechanisms that shape the physiology and interactions of this AMF with plants. Here, we used all published genomics, transcriptomics, and metabolomics resources to gain insights into the metabolic functionalities of R. irregularis by reconstructing its high-quality genome-scale metabolic network that considers enzyme constraints. Extensive validation tests with the enzyme-constrained metabolic model demonstrated that it can be used to (i) accurately predict increased growth of R. irregularis on myristate with minimal medium; (ii) integrate enzyme abundances and carbon source concentrations that yield growth predictions with high and significant Spearman correlation (rS = 0.74) to measured hyphal dry weight; and (iii) simulate growth rate increases with tighter association of this AMF with the host plant across three fungal structures. Based on the validated model and system-level analyses that integrate data from transcriptomics studies, we predicted that differences in flux distributions between intraradical mycelium and arbuscles are linked to changes in amino acid and cofactor biosynthesis. Therefore, our results demonstrated that the enzyme-constrained metabolic model can be employed to pinpoint mechanisms driving developmental and physiological responses of R. irregularis to different environmental cues. In conclusion, this model can serve as a template for other AMF and paves the way to identify metabolic engineering strategies to modulate fungal metabolic traits that directly affect plant performance. IMPORTANCE Mounting evidence points to the benefits of the symbiotic interactions between the arbuscular mycorrhiza fungus Rhizophagus irregularis and crops; however, the molecular mechanisms underlying the physiological responses of this fungus to different host plants and environments remain largely unknown. We present a manually curated, enzyme-constrained, genome-scale metabolic model of R. irregularis that can accurately predict experimentally observed phenotypes. We show that this high-quality model provides an entry point into better understanding the metabolic and physiological responses of this fungus to changing environments due to the availability of different nutrients. The model can be used to design metabolic engineering strategies to tailor R. irregularis metabolism toward improving the performance of host plants. KW - Rhizophagus irregularis KW - metabolic modeling Y1 - 2022 U6 - https://doi.org/10.1128/msystems.01216-21 SN - 2379-5077 VL - 7 IS - 1 PB - American Society for Microbiology CY - Washington, DC ER - TY - JOUR A1 - Sagu Tchewonpi, Sorel A1 - Rawel, Harshadrai M. A1 - Rohn, Sascha T1 - Targeted bottom-up mass spectrometry approach for the relative quantification of post-translational modification of bovine κ-casein during milk fermentation JF - Molecules N2 - kappa-casein (kappa-CN) is one of the key components in bovine milk, playing a unique role in the structuration of casein micelles. It contains in its chemical structure up to sixteen amino acid residues (mainly serine and threonine) susceptible to modifications, including glycosylation and phosphorylation, which may further be formed during milk processing. In this study, changes in post-translational modification (PTM) of kappa-CN during bovine milk fermentation were investigated. One-to-five-day fermented milk samples were produced. A traditional bottom-up proteomics approach was used to establish a multiple-reaction monitoring (MRM) method for relative quantification of kappa-CN PTM. Endoproteinase Glu-C was found to efficiently digest the kappa-CN molecule. The developed LC-MS method was validated by performing assessments of linearity, precision, repeatability, reproducibility, limit of detection (LOD), and limit of quantification (LOQ). Among the yielded peptides, four of them containing serine and threonine residues were identified and the unmodified as well as the modified variants of each of them were relatively quantified. These peptides were (1) IPTINTIASGEPTSTTE ([140, 158]), (2) STVATLE ([162, 168]), (3) DSPE ([169, 172]), and (4) INTVQVTSTAV ([180, 190]). Distribution analysis between unmodified and modified peptides revealed that over 50% of kappa-CN was found in one of its modified forms in milk. The fermentation process further significantly altered the composition between unmodified/modified kappa-CN, with glycoslaytion being predominant compared to phosphorylation (p < 0.01). Further method development towards alpha and beta-CN fractions and their PTM behavior would be an asset to better understand the changes undergone by milk proteins and the micellar structure during fermentation. KW - bovine milk KW - fermentation KW - kappa-casein KW - post-translational modifications KW - glycosylation KW - phosphorylation KW - mass spectrometry Y1 - 2022 U6 - https://doi.org/10.3390/molecules27185834 SN - 1420-3049 VL - 27 IS - 18 PB - MDPI CY - Basel ER - TY - JOUR A1 - Geng, Rongwei A1 - Andreev, Andrei A1 - Kruse, Stefan A1 - Heim, Birgit A1 - van Geffen, Femke A1 - Pestryakova, Luidmila A1 - Zakharov, Evgenii A1 - Troeva, Elena I. A1 - Shevtsova, Iuliia A1 - Li, Furong A1 - Zhao, Yan A1 - Herzschuh, Ulrike T1 - Modern pollen assemblages from lake sediments and soil in East Siberia and relative pollen productivity estimates for Major Taxa JF - Frontiers in Ecology and Evolution N2 - Modern pollen-vegetation-climate relationships underpin palaeovegetation and palaeoclimate reconstructions from fossil pollen records. East Siberia is an ideal area for investigating the relationships between modern pollen assemblages and near natural vegetation under cold continental climate conditions. Reliable pollen-based quantitative vegetation and climate reconstructions are still scarce due to the limited number of modern pollen datasets. Furthermore, differences in pollen representation of samples from lake sediments and soils are not well understood. Here, we present a new pollen dataset of 48 moss/soil and 24 lake surface-sediment samples collected in Chukotka and central Yakutia in East Siberia. The pollen-vegetation-climate relationships were investigated by ordination analyses. Generally, tundra and taiga vegetation types can be well distinguished in the surface pollen assemblages. Moss/soil and lake samples contain generally similar pollen assemblages as revealed by a Procrustes comparison with some exceptions. Overall, modern pollen assemblages reflect the temperature and precipitation gradients in the study areas as revealed by constrained ordination analysis. We estimate the relative pollen productivity (RPP) of major taxa and the relevant source area of pollen (RSAP) for moss/soil samples from Chukotka and central Yakutia using Extended R-Value (ERV) analysis. The RSAP of the tundra-forest transition area in Chukotka and taiga area in central Yakutia are ca. 1300 and 360 m, respectively. For Chukotka, RPPs relative to both Poaceae and Ericaceae were estimated while RPPs for central Yakutia were relative only to Ericaceae. Relative to Ericaceae (reference taxon, RPP = 1), Larix, Betula, Picea, and Pinus are overrepresented while Alnus, Cyperaceae, Poaceae, and Salix are underrepresented in the pollen spectra. Our estimates are in general agreement with previously published values and provide the basis for reliable quantitative reconstructions of East Siberian vegetation. KW - modern pollen assemblages KW - pollen-vegetation-climate relationships KW - East Siberia KW - tundra KW - taiga KW - relative pollen productivity KW - quantitative vegetation reconstruction Y1 - 2022 U6 - https://doi.org/10.3389/fevo.2022.837857 SN - 2296-701X VL - 10 PB - Frontiers Media CY - Lausanne ER -