TY - JOUR A1 - Schad, Daniel A1 - Vasishth, Shravan T1 - The posterior probability of a null hypothesis given a statistically significant result JF - The quantitative methods for psychology N2 - When researchers carry out a null hypothesis significance test, it is tempting to assume that a statistically significant result lowers Prob(H0), the probability of the null hypothesis being true. Technically, such a statement is meaningless for various reasons: e.g., the null hypothesis does not have a probability associated with it. However, it is possible to relax certain assumptions to compute the posterior probability Prob(H0) under repeated sampling. We show in a step-by-step guide that the intuitively appealing belief, that Prob(H0) is low when significant results have been obtained under repeated sampling, is in general incorrect and depends greatly on: (a) the prior probability of the null being true; (b) type-I error rate, (c) type-II error rate, and (d) replication of a result. Through step-by-step simulations using open-source code in the R System of Statistical Computing, we show that uncertainty about the null hypothesis being true often remains high despite a significant result. To help the reader develop intuitions about this common misconception, we provide a Shiny app (https://danielschad.shinyapps.io/probnull/). We expect that this tutorial will help researchers better understand and judge results from null hypothesis significance tests. KW - Null hypothesis significance testing KW - Bayesian inference KW - statistical KW - power Y1 - 2022 U6 - https://doi.org/10.20982/tqmp.18.2.p011 SN - 1913-4126 SN - 2292-1354 VL - 18 IS - 2 SP - 130 EP - 141 PB - University of Montreal, Department of Psychology CY - Montreal ER - TY - JOUR A1 - Schmicker, Marlen A1 - Frühling, Insa A1 - Menze, Inga A1 - Glanz, Wenzel A1 - Müller, Patrick A1 - Noesselt, Toemme A1 - Müller, Notger Germar T1 - The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline JF - Journal of Alzheimer's disease reports : JADR N2 - Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit. Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients. Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition. KW - Alzheimer's disease KW - dementia KW - diagnostic marker KW - early diagnosis KW - subjective cognitive decline KW - taste Y1 - 2023 U6 - https://doi.org/10.3233/ADR220092 SN - 2542-4823 VL - 7 IS - 1 SP - 249 EP - 262 PB - IOS Press CY - Clifton, VA ER - TY - JOUR A1 - Lin, Chiao-I A1 - Mayer, Frank A1 - Wippert, Pia-Maria T1 - The prevalence of chronic ankle instability in basketball athletes BT - a cross-sectional study JF - BMC sports science, medicine & rehabilitation N2 - Background Ankle sprain is the most common injury in basketball. Chronic ankle instability develops from an acute ankle sprain may cause negative effects on quality of life, ankle functionality or on increasing risk for recurrent ankle sprains and post-traumatic osteoarthritis. To facilitate a preventative strategy of chronic ankle instability (CAI) in the basketball population, gathering epidemiological data is essential. However, the epidemiological data of CAI in basketball is limited. Therefore, this study aims to investigate the prevalence of CAI in basketball athletes and to determine whether gender, competitive level, and basketball playing position influence this prevalence. Methods In a cross-sectional study, in total 391 Taiwanese basketball athletes from universities and sports clubs participated. Besides non-standardized questions about demographics and their history of ankle sprains, participants further filled out the standard Cumberland Ankle Instability Tool applied to determine the presence of ankle instability. Questionnaires from 255 collegiate and 133 semi-professional basketball athletes (male = 243, female = 145, 22.3 +/- 3.8 years, 23.3 +/- 2.2 kg/m(2)) were analyzed. Differences in prevalence between gender, competitive level and playing position were determined using the Chi-square test. Results In the surveyed cohort, 26% had unilateral CAI while 50% of them had bilateral CAI. Women had a higher prevalence than men in the whole surveyed cohort (X-2(1) = 0.515, p = 0.003). This gender disparity also showed from sub-analyses, that the collegiate female athletes had a higher prevalence than collegiate men athletes (X-2(1) = 0.203, p = 0.001). Prevalence showed no difference between competitive levels (p > 0.05) and among playing positions (p > 0.05). Conclusions CAI is highly prevalent in the basketball population. Gender affects the prevalence of CAI. Regardless of the competitive level and playing position the prevalence of CAI is similar. The characteristic of basketball contributes to the high prevalence. Prevention of CAI should be a focus in basketball. When applying the CAI prevention measures, gender should be taken into consideration. KW - Functional ankle instability KW - Perceived ankle instability KW - Ankle sprain; KW - Ankle injury KW - Survey KW - Basketball Y1 - 2022 U6 - https://doi.org/10.1186/s13102-022-00418-0 SN - 2052-1847 VL - 14 IS - 1 PB - BMC CY - London ER - TY - JOUR A1 - Steinrötter, Björn T1 - The principle of equivalence of legal systems in private international law and its contribution to the foundation and preservation of peace T1 - Princip jednakosti pravnih sistema u međunarodnom privatnom pravu i njegov doprinos uspostavljanju i očuvanju mira T1 - Принцип једнакости правних система у међународном приватном праву и његов допринос успостављању и очувању мира JF - Zbornik radova Pravnog fakulteta, Novi Sad JF - Зборник радова Правног факултета у Новом Саду N2 - Private international law (PIL) might seem disconnected from peacebuilding and peacekeeping efforts. However, this perception falls short. PIL, contrary to public international law’s direct peacekeeping potential, indirectly contributes to peace by fostering mutual respect between states. The relationship between PIL and peace stems from the recognition and respect states show for each other’s legal systems. PIL operates on the principle of comity, where states acknowledge the applicability of foreign laws to resolve cases. In essence, while PIL’s impact on peace is indirect and modest, its emphasis on mutual respect and fair treatment contributes to peaceful relations between states, making it an important element in the broader context of peacebuilding and peacekeeping efforts. Private international law (PIL) does not determine substantive fairness for parties but focuses on localizing cases at a meta-level of conflict-of-laws. This localization is guided by party, trade, and regulatory interests, and is rooted in neutrality and respect for other legal systems. While the principle of equivalence and neutrality remains foundational in PIL, exceptions and limitations have been established over time to address specific scenarios, ensuring a balanced approach that respects both foreign legal systems and fundamental legal principles. N2 - Na prvi pogled može delovati da Međunarodno privatno pravo (MPP) nema veze sa naporima za uspostavljanje i očuvanje mira. Međutim, ova percepcija nije utemeljena. Suprotno neposrednom potencijalu međunarodnog javnog prava za očuvanje mira, MPP indirektno doprinosi miru podsticanjem međusobnog poštovanja između država. Odnos između MPP i mira proizlazi iz poštovanja koje države iskazuju prema pravnim sistemima drugih država. MPP funkcioniše na osnovu principa uzajamnog uvažavanja, gde države priznaju primenljivost stranih zakona za rešavanje slučajeva. U suštini, iako je uticaj MPP-a na mir indirektan i skroman, njegov naglasak na međusobnom poštovanju i pravičnom postupanju doprinosi pomirljivom tonu u odnosu između država, čineći ga važnim elementom u širem kontekstu izgradnje i očuvanja mira. MPP nema neposredni doprinos u postzanju suštinske pravičnost među stranama spora, već se fokusira na lokalizaciju slučajeva na meta-nivou sukoba zakona. Ova lokalizacija se vodi stranačkim, trgovinskim i regulatornim interesima i ukorenjena je u neutralnosti i poštovanju drugih pravnih sistema. Iako princip ekvivalencije i neutralnosti ostaje temeljni u MPP-u, su vremenom uspostavljeni izuzeci i ograničenja kako bi se adresirali specifični scenariji, osiguravajući uravnotežen pristup koji poštuje i strane pravne sisteme i temeljne pravne principe. N2 - На први поглед може деловати да Међународно приватно право (МПП) нема везе са напорима за успостављање и очување мира. Међутим, ова перцепција није утемељена. Супротно непосредном потенцијалу међународног јавног права за очување мира, МПП индиректно доприноси миру подстицањем међусобног поштовања између држава. Однос између МПП и мира произлази из поштовања које државе исказују према правним системима других држава. МПП функционише на основу принципа узајамног уважавања, где државе признају применљивост страних закона за решавање случајева. У суштини, иако је утицај МПП-а на мир индиректан и скроман, његов нагласак на међусобном поштовању и правичном поступању доприноси помирљивом тону у односу између држава, чинећи га важним елементом у ширем контексту изградње и очувања мира. МПП нема непосредни допринос у постзању суштинске правичност међу странама спора, већ се фокусира на локализацију случајева на мета-нивоу сукоба закона. Ова локализација се води страначким, трговинским и регулаторним интересима и укорењена је у неутралности и поштовању других правних система. Иако принцип еквиваленције и неутралности остаје темељни у МПП-у, су временом успостављени изузеци и ограничења како би се адресирали специфични сценарији, осигуравајући уравнотежен приступ који поштује и стране правне системе и темељне правне принципе. KW - Private International Law KW - peacebuilding and peacekeeping KW - mutual respect KW - comity KW - equivalence KW - međunarodno privatno pravo KW - uspostavljanje i održavanje mira KW - uzajamno poštovanje i uvažavanje KW - jednakost KW - међународно приватно право KW - успостављање и одржавање мира KW - узајамно поштовање и уважавање KW - једнакост Y1 - 2023 U6 - https://doi.org/10.5937/zrpfns57-40597 SN - 0550-2179 SN - 2406-1255 VL - 57 IS - 3 SP - 991 EP - 1004 PB - Univerzitet u Novom Sadu / Pravni Fakultet CY - Novi Sad ER - TY - JOUR A1 - Bryant, Seth A1 - Davies, Evan A1 - Sol, David A1 - Davis, Sandy T1 - The progression of flood risk in southern Alberta since the 2013 flood JF - Journal of flood risk management N2 - After a century of semi-restricted floodplain development, Southern Alberta, Canada, was struck by the devastating 2013 Flood. Aging infrastructure and limited property-level floodproofing likely contributed to the $4-6 billion (CAD) losses. Following this catastrophe, Alberta has seen a revival in flood management, largely focused on structural protections. However, concurrent with the recent structural work was a 100,000+ increase in Calgary's population in the 5 years following the flood, leading to further densification of high-hazard areas. This study implements the novel Stochastic Object-based Flood damage Dynamic Assessment (SOFDA) model framework to quantify the progression of the direct-damage flood risk in a mature urban neighborhood after the 2013 Flood. Five years of remote-sensing data, property assessment records, and inundation simulations following the flood are used to construct the model. Results show that in these 5 years, vulnerability trends (like densification) have increased flood risk by 4%; however, recent structural mitigation projects have reduced overall flood risk by 47% for this case study. These results demonstrate that the flood management revival in Southern Alberta has largely been successful at reducing flood risk; however, the gains are under threat from continued development and densification absent additional floodproofing regulations. KW - Calgary KW - depth-damage functions KW - expected annual damages KW - flood risk KW - model KW - property level protection measures KW - risk analysis KW - risk dynamics Y1 - 2022 U6 - https://doi.org/10.1111/jfr3.12811 SN - 1753-318X VL - 15 IS - 3 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Börnert-Ringleb, Moritz A1 - Westphal, Andrea A1 - Zaruba, Nicole A1 - Gutmann, Franziska A1 - Vock, Miriam T1 - The relationship between attitudes toward inclusion, beliefs about teaching and learning, and subsequent automatic evaluations amongst student teachers JF - Frontiers in education N2 - Teachers' attitudes toward inclusion are frequently cited as being an important predictor of how successfully a given inclusive school system is implemented. At the same time, beliefs about the nature of teaching and learning are discussed as a possible predictor of attitudes toward inclusion. However, more recent research emphasizes the need of considering implicit processes, such as automatic evaluations, when describing attitudes and beliefs. Previous evidence on the association of attitudes toward inclusion and beliefs about teaching and learning is solely based on explicit reports. Therefore, this study aims to examine the relationship between attitudes toward inclusion, beliefs about teaching and learning, and the subsequent automatic evaluations of pre-service teachers (N = 197). The results revealed differences between pre-service teachers' explicit attitudes/beliefs and their subsequent automatic evaluations. Differences in the relationship between attitudes toward inclusion and beliefs about teaching and learning occur when teachers focus either on explicit measures or automatic evaluations. These differences might be due to different facets of the same attitude object being represented. Relying solely on either explicit measures or automatic evaluations at the exclusion of the other might lead to erroneous assumptions about the relation of attitudes toward inclusion and beliefs about teaching and learning. KW - inclusion KW - attitudes KW - teaching KW - automatic evaluation KW - beliefs KW - implicit Y1 - 2020 U6 - https://doi.org/10.3389/feduc.2020.584464 SN - 2504-284X VL - 5 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Mendel, Ralf R. A1 - Hercher, Thomas W. A1 - Zupok, Arkadiusz A1 - Hasnat, Muhammad Abrar A1 - Leimkühler, Silke T1 - The requirement of inorganic Fe-S clusters for the biosynthesis of the organometallic molybdenum cofactor JF - Inorganics : open access journal N2 - Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containing prosthetic groups like the molybdenum cofactor (Moco). Here, we give an overview of the assembly of Fe-S clusters in bacteria and humans and present their connection to the Moco biosynthesis pathway. In all organisms, Fe-S cluster assembly starts with the abstraction of sulfur froml-cysteine and its transfer to a scaffold protein. After formation, Fe-S clusters are transferred to carrier proteins that insert them into recipient apo-proteins. In eukaryotes like humans and plants, Fe-S cluster assembly takes place both in mitochondria and in the cytosol. Both Moco biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. Moco is a tricyclic pterin compound with molybdenum coordinated through its unique dithiolene group. Moco biosynthesis begins in the mitochondria in a Fe-S cluster dependent step involving radical/S-adenosylmethionine (SAM) chemistry. An intermediate is transferred to the cytosol where the dithiolene group is formed, to which molybdenum is finally added. Further connections between Fe-S cluster assembly and Moco biosynthesis are discussed in detail. KW - Moco biosynthesis KW - Fe-S cluster assembly KW - l-cysteine desulfurase KW - ISC KW - SUF KW - NIF KW - iron KW - molybdenum KW - sulfur Y1 - 2020 U6 - https://doi.org/10.3390/inorganics8070043 SN - 2304-6740 VL - 8 IS - 7 PB - MDPI CY - Basel ER - TY - JOUR A1 - Reich, Eli T1 - The return of liberal rabbinic education to Berlin BT - Abraham Geiger College, Zacharias Frankel College and the School of Jewish Theology JF - Nordisk judaistik = Scandinavian Jewish studies N2 - In Berlin two rabbinical seminaries, a Reform and a Conservative, have recently been established. The historical and intellectual roots of these institutions in the nineteenth century is sketched, and then contrasted with the present curriculum and the religious profile of the students. Some theological questions for the future of these projects conclude the article. KW - Abraham Geiger College KW - Zacharias Frankel College KW - the School of Jewish Theology KW - rabbinic education in Berlin Y1 - 2020 U6 - https://doi.org/10.30752/nj.84891 SN - 0348-1646 SN - 2343-4929 VL - 31 IS - 1 SP - 87 EP - 92 PB - Donner Institute CY - Åbo ER - TY - JOUR A1 - Bielcik, Milos A1 - Aguilar-Trigueros, Carlos A. A1 - Lakovic, Milica A1 - Jeltsch, Florian A1 - Rillig, Matthias C. T1 - The role of active movement in fungal ecology and community assembly JF - Movement Ecology N2 - Movement ecology aims to provide common terminology and an integrative framework of movement research across all groups of organisms. Yet such work has focused on unitary organisms so far, and thus the important group of filamentous fungi has not been considered in this context. With the exception of spore dispersal, movement in filamentous fungi has not been integrated into the movement ecology field. At the same time, the field of fungal ecology has been advancing research on topics like informed growth, mycelial translocations, or fungal highways using its own terminology and frameworks, overlooking the theoretical developments within movement ecology. We provide a conceptual and terminological framework for interdisciplinary collaboration between these two disciplines, and show how both can benefit from closer links: We show how placing the knowledge from fungal biology and ecology into the framework of movement ecology can inspire both theoretical and empirical developments, eventually leading towards a better understanding of fungal ecology and community assembly. Conversely, by a greater focus on movement specificities of filamentous fungi, movement ecology stands to benefit from the challenge to evolve its concepts and terminology towards even greater universality. We show how our concept can be applied for other modular organisms (such as clonal plants and slime molds), and how this can lead towards comparative studies with the relationship between organismal movement and ecosystems in the focus. KW - Filamentous fungi KW - Microbial community KW - Active movement KW - Modular organisms KW - Interference competition KW - Fungal space searching algorithms KW - Fungal foraging KW - Fungal highways KW - Clonal plants KW - Slime molds Y1 - 2019 U6 - https://doi.org/10.1186/s40462-019-0180-6 SN - 2051-3933 VL - 7 IS - 1 PB - BMC CY - London ER - TY - JOUR A1 - Rothermel, Ann-Kathrin T1 - The role of evidence-based misogyny in antifeminist online communities of the ‘manosphere’ JF - Big data & society N2 - In recent years, there have been a growing number of online and offline attacks linked to a loosely connected network of misogynist and antifeminist online communities called ‘the manosphere’. Since 2016, the ideas spread among and by groups of the manosphere have also become more closely aligned with those of other Far-Right online networks. In this commentary, I explore the role of what I term ‘evidence-based misogyny’ for mobilization and radicalization into the antifeminist and misogynist subcultures of the manosphere. Evidence-based misogyny is a discursive strategy, whereby members of the manosphere refer to (and misinterpret) knowledge in the form of statistics, studies, news items and pop-culture and mimic accepted methods of knowledge presentation to support their essentializing, polarizing views about gender relations in society. Evidence-based misogyny is a core aspect for manosphere-related mobilization as it provides a false sense of authority and forges a collective identity, which is framed as a supposed ‘alternative’ to mainstream gender knowledge. Due to its core function to justify and confirm the misogynist sentiments of users, evidence-based misogyny serves as connector between the manosphere and both mainstream conservative as well as other Far-Right and conspiratorial discourses. KW - misogyny KW - male supremacy KW - far right KW - discourse KW - incels KW - radicalization KW - antifeminist KW - men's rights KW - manosphere Y1 - 2023 U6 - https://doi.org/10.1177/20539517221145671 SN - 2053-9517 VL - 10 IS - 1 PB - Sage CY - Thousand Oaks, Calif. ER - TY - JOUR A1 - Johann, Kornelia A1 - Kleinert, Maximilian A1 - Klaus, Susanne T1 - The role of GDF15 as a myomitokine JF - Cells N2 - Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic energy metabolism through its anorectic action. GDF15 expression and secretion from various organs and tissues is induced in different physiological and pathophysiological states, often linked to mitochondrial stress, leading to highly variable circulating GDF15 levels. In skeletal muscle and the heart, the basal expression of GDF15 is very low compared to other organs, but GDF15 expression and secretion can be induced in various stress conditions, such as intense exercise and acute myocardial infarction, respectively. GDF15 is thus considered as a myokine and cardiokine. GFRAL, the exclusive receptor for GDF15, is expressed in hindbrain neurons and activation of the GDF15-GFRAL pathway is linked to an increased sympathetic outflow and possibly an activation of the hypothalamic-pituitary-adrenal (HPA) stress axis. There is also evidence for peripheral, direct effects of GDF15 on adipose tissue lipolysis and possible autocrine cardiac effects. Metabolic and behavioral outcomes of GDF15 signaling can be beneficial or detrimental, likely depending on the magnitude and duration of the GDF15 signal. This is especially apparent for GDF15 production in muscle, which can be induced both by exercise and by muscle disease states such as sarcopenia and mitochondrial myopathy. KW - anorexia KW - appetite regulation KW - cardiokine KW - cytokine KW - exercise KW - mitochondria KW - muscle KW - myokine KW - myopathy KW - sarcopenia Y1 - 2021 U6 - https://doi.org/10.3390/cells10112990 SN - 2073-4409 VL - 10 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Fairey, Brenton J. A1 - Timmerman, Martin Jan A1 - Sudo, Masafumi A1 - Tsikos, Harilaos T1 - The role of hydrothermal activity in the formation of Karst-hosted manganese deposits of the Postmasburg Mn Field, Northern Cape Province, South Africa JF - Minerals N2 - The Postmasburg Manganese Field (PMF), Northern Cape Province, South Africa, once represented one of the largest sources of manganese ore worldwide. Two belts of manganese ore deposits have been distinguished in the PMF, namely the Western Belt of ferruginous manganese ores and the Eastern Belt of siliceous manganese ores. Prevailing models of ore formation in these two belts invoke karstification of manganese-rich dolomites and residual accumulation of manganese wad which later underwent diagenetic and low-grade metamorphic processes. For the most part, the role of hydrothermal processes and metasomatic alteration towards ore formation has not been adequately discussed. Here we report an abundance of common and some rare Al-, Na-, K- and Ba-bearing minerals, particularly aegirine, albite, microcline, banalsite, serandite-pectolite, paragonite and natrolite in Mn ores of the PMF, indicative of hydrothermal influence. Enrichments in Na, K and/or Ba in the ores are generally on a percentage level for most samples analysed through bulk-rock techniques. The presence of As-rich tokyoite also suggests the presence of As and V in the hydrothermal fluid. The fluid was likely oxidized and alkaline in nature, akin to a mature basinal brine. Various replacement textures, particularly of Na- and K- rich minerals by Ba-bearing phases, suggest sequential deposition of gangue as well as ore-minerals from the hydrothermal fluid, with Ba phases being deposited at a later stage. The stratigraphic variability of the studied ores and their deviation from the strict classification of ferruginous and siliceous ores in the literature, suggests that a re-evaluation of genetic models is warranted. New Ar-Ar ages for K-feldspars suggest a late Neoproterozoic timing for hydrothermal activity. This corroborates previous geochronological evidence for regional hydrothermal activity that affected Mn ores at the PMF but also, possibly, the high-grade Mn ores of the Kalahari Manganese Field to the north. A revised, all-encompassing model for the development of the manganese deposits of the PMF is then proposed, whereby the source of metals is attributed to underlying carbonate rocks beyond the Reivilo Formation of the Campbellrand Subgroup. The main process by which metals are primarily accumulated is attributed to karstification of the dolomitic substrate. The overlying Asbestos Hills Subgroup banded iron formation (BIF) is suggested as a potential source of alkali metals, which also provides a mechanism for leaching of these BIFs to form high-grade residual iron ore deposits. KW - manganese ore KW - Postmasburg manganese field KW - hydrothermal KW - karst KW - South Africa Y1 - 2019 U6 - https://doi.org/10.3390/min9070408 SN - 2075-163X VL - 9 IS - 7 PB - MDPI CY - Basel ER - TY - JOUR A1 - Metin, Ayse Duha A1 - Dung, Nguyen Viet A1 - Schröter, Kai A1 - Vorogushyn, Sergiy A1 - Guse, Björn A1 - Kreibich, Heidi A1 - Merz, Bruno T1 - The role of spatial dependence for large-scale flood risk estimation JF - Natural hazards and earth system sciences N2 - Flood risk assessments are typically based on scenarios which assume homogeneous return periods of flood peaks throughout the catchment. This assumption is unrealistic for real flood events and may bias risk estimates for specific return periods. We investigate how three assumptions about the spatial dependence affect risk estimates: (i) spatially homogeneous scenarios (complete dependence), (ii) spatially heterogeneous scenarios (modelled dependence) and (iii) spatially heterogeneous but uncorrelated scenarios (complete independence). To this end, the model chain RFM (regional flood model) is applied to the Elbe catchment in Germany, accounting for the spatio-temporal dynamics of all flood generation processes, from the rainfall through catchment and river system processes to damage mechanisms. Different assumptions about the spatial dependence do not influence the expected annual damage (EAD); however, they bias the risk curve, i.e. the cumulative distribution function of damage. The widespread assumption of complete dependence strongly overestimates flood damage of the order of 100% for return periods larger than approximately 200 years. On the other hand, for small and medium floods with return periods smaller than approximately 50 years, damage is underestimated. The overestimation aggravates when risk is estimated for larger areas. This study demonstrates the importance of representing the spatial dependence of flood peaks and damage for risk assessments. Y1 - 2020 U6 - https://doi.org/10.5194/nhess-20-967-2020 SN - 1561-8633 SN - 1684-9981 VL - 20 IS - 4 SP - 967 EP - 979 PB - European Geosciences Union (EGU) ; Copernicus CY - Göttingen ER - TY - JOUR A1 - Romanowsky, Erik A1 - Handorf, Dörthe A1 - Jaiser, Ralf A1 - Wohltmann, Ingo A1 - Dorn, Wolfgang A1 - Ukita, Jinro A1 - Cohen, Judah A1 - Dethloff, Klaus A1 - Rex, Markus T1 - The role of stratospheric ozone for Arctic-midlatitude linkages JF - Scientific reports N2 - Arctic warming was more pronounced than warming in midlatitudes in the last decades making this region a hotspot of climate change. Associated with this, a rapid decline of sea-ice extent and a decrease of its thickness has been observed. Sea-ice retreat allows for an increased transport of heat and momentum from the ocean up to the tropo- and stratosphere by enhanced upward propagation of planetary-scale atmospheric waves. In the upper atmosphere, these waves deposit the momentum transported, disturbing the stratospheric polar vortex, which can lead to a breakdown of this circulation with the potential to also significantly impact the troposphere in mid- to late-winter and early spring. Therefore, an accurate representation of stratospheric processes in climate models is necessary to improve the understanding of the impact of retreating sea ice on the atmospheric circulation. By modeling the atmospheric response to a prescribed decline in Arctic sea ice, we show that including interactive stratospheric ozone chemistry in atmospheric model calculations leads to an improvement in tropo-stratospheric interactions compared to simulations without interactive chemistry. This suggests that stratospheric ozone chemistry is important for the understanding of sea ice related impacts on atmospheric dynamics. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-43823-1 SN - 2045-2322 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Schütze, Franziska A1 - Fürst, Steffen A1 - Mielke, Jahel A1 - Steudle, Gesine A. A1 - Wolf, Sarah A1 - Jäger, Carlo C. T1 - The Role of Sustainable Investment in Climate Policy JF - Sustainability N2 - Reaching the Sustainable Development Goals requires a fundamental socio-economic transformation accompanied by substantial investment in low-carbon infrastructure. Such a sustainability transition represents a non-marginal change, driven by behavioral factors and systemic interactions. However, typical economic models used to assess a sustainability transition focus on marginal changes around a local optimum, whichby constructionlead to negative effects. Thus, these models do not allow evaluating a sustainability transition that might have substantial positive effects. This paper examines which mechanisms need to be included in a standard computable general equilibrium model to overcome these limitations and to give a more comprehensive view of the effects of climate change mitigation. Simulation results show that, given an ambitious greenhouse gas emission constraint and a price of carbon, positive economic effects are possible if (1) technical progress results (partly) endogenously from the model and (2) a policy intervention triggering an increase of investment is introduced. Additionally, if (3) the investment behavior of firms is influenced by their sales expectations, the effects are amplified. The results provide suggestions for policy-makers, because the outcome indicates that investment-oriented climate policies can lead to more desirable outcomes in economic, social and environmental terms. KW - climate policy KW - green growth KW - macroeconomic models KW - sustainable investment KW - technical progress KW - expectations KW - 1.5 degrees C Y1 - 2017 U6 - https://doi.org/10.3390/su9122221 SN - 2071-1050 VL - 9 PB - MDPI CY - Basel ER - TY - GEN A1 - Schütze, Franziska A1 - Fürst, Steffen A1 - Mielke, Jahel A1 - Steudle, Gesine A. A1 - Wolf, Sarah A1 - Jäger, Carlo C. T1 - The Role of Sustainable Investment in Climate Policy T2 - Postprints der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe N2 - Reaching the Sustainable Development Goals requires a fundamental socio-economic transformation accompanied by substantial investment in low-carbon infrastructure. Such a sustainability transition represents a non-marginal change, driven by behavioral factors and systemic interactions. However, typical economic models used to assess a sustainability transition focus on marginal changes around a local optimum, whichby constructionlead to negative effects. Thus, these models do not allow evaluating a sustainability transition that might have substantial positive effects. This paper examines which mechanisms need to be included in a standard computable general equilibrium model to overcome these limitations and to give a more comprehensive view of the effects of climate change mitigation. Simulation results show that, given an ambitious greenhouse gas emission constraint and a price of carbon, positive economic effects are possible if (1) technical progress results (partly) endogenously from the model and (2) a policy intervention triggering an increase of investment is introduced. Additionally, if (3) the investment behavior of firms is influenced by their sales expectations, the effects are amplified. The results provide suggestions for policy-makers, because the outcome indicates that investment-oriented climate policies can lead to more desirable outcomes in economic, social and environmental terms. T3 - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 137 KW - climate policy KW - green growth KW - macroeconomic models KW - sustainable investment KW - technical progress KW - expectations KW - 1.5 degrees C Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470485 SN - 1867-5808 IS - 137 ER - TY - JOUR A1 - Krupkova, Olga A1 - Zvick, Johannes A1 - Würtz-Kozak, Karin T1 - The role of transient receptor potential channels in joint diseases JF - European cells & materials N2 - Transient receptor potential channels (TRP channels) are cation selective transmembrane receptors with diverse structures, activation mechanisms and physiological functions. TRP channels act as cellular sensors for a plethora of stimuli, including temperature, membrane voltage, oxidative stress, mechanical stimuli, pH and endogenous as well as exogenous ligands, thereby illustrating their versatility. As such, TRP channels regulate various functions in both excitable and non-excitable cells, mainly by mediating Ca2+ homeostasis. Dysregulation of TRP channels is implicated in many pathologies, including cardiovascular diseases, muscular dystrophies and hyperalgesia. However, the importance of TRP channel expression, physiological function and regulation in chondrocytes and intervertebral disc (IVD) cells is largely unexplored. Osteoarthritis (OA) and degenerative disc disease (DDD) are chronic age-related disorders that significantly affect the quality of life by causing pain, activity limitation and disability. Furthermore, currently available therapies cannot effectively slow-down or stop progression of these diseases. Both OA and DDD are characterised by reduced tissue cellularity, enhanced inflammatory responses and molecular, structural and mechanical alterations of the extracellular matrix, hence affecting load distribution and reducing joint flexibility. However, knowledge on how chondrocytes and IVD cells sense their microenvironment and respond to its changes is still limited. In this review, we introduced six families of mammalian TRP channels, their mechanisms of activation as well as activation-driven cellular consequences. We summarised the current knowledge on TRP channel expression and activity in chondrocytes and IVD cells and the significance of TRP channels as therapeutic targets for the treatment of OA and DDD. KW - Transient receptor potential channels KW - degenerative disc disease KW - osteoarthritis KW - nociception KW - mechanosensing KW - osmosensing KW - inflammation KW - calcium Y1 - 2017 U6 - https://doi.org/10.22203/eCM.v034a12 SN - 1473-2262 VL - 34 SP - 180 EP - 201 PB - Univ. of Wales CY - Aberystwyth ER - TY - JOUR A1 - Zhang, Zhihao A1 - Wang, Ting A1 - Kuang, Jin A1 - Herold, Fabian A1 - Ludyga, Sebastian A1 - Li, Jingming A1 - Hall, Daniel L. A1 - Taylor, Alyx A1 - Healy, Sean A1 - Yeung, Albert S. A1 - Kramer, Arthur F. A1 - Zou, Liye T1 - The roles of exercise tolerance and resilience in the effect of physical activity on emotional states among college students JF - International Journal of Clinical and Health Psychology N2 - Background/objective: Negative emotional states, such as depression, anxiety, and stress challenge health care due to their long-term consequences for mental disorders. Accumulating evidence indicates that regular physical activity (PA) can positively influence negative emotional states. Among possible candidates, resilience and exercise tolerance in particular have the potential to partly explain the positive effects of PA on negative emotional states. Thus, the aim of this study was to investigate the association between PA and negative emotional states, and further determine the mediating effects of exercise tolerance and resilience in such a relationship. Method: In total, 1117 Chinese college students (50.4% female, Mage=18.90, SD=1.25) completed a psychosocial battery, including the 21-item Depression Anxiety Stress Scale (DASS-21), the Connor-Davidson Resilience Scale (CD-RISC), the Preference for and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q), and the International Physical Activity Questionnaire short form (IPAQ-SF). Regression analysis was used to identify the serial multiple mediation, controlling for gender, age and BMI. Results: PA, exercise intensity-tolerance, and resilience were significantly negatively correlated with negative emotional states (Ps<.05). Further, exercise tolerance and resilience partially mediated the relationship between PA and negative emotional states. Conclusions: Resilience and exercise intensity-tolerance can be achieved through regularly engaging in PA, and these newly observed variables play critical roles in prevention of mental illnesses, especially college students who face various challenges. Recommended amount of PA should be incorporated into curriculum or sport clubs within a campus environment. KW - Exercise tolerance KW - Resilience KW - Physical activity KW - Emotion KW - Depression Y1 - 2022 U6 - https://doi.org/10.1016/j.ijchp.2022.100312 SN - 1697-2600 SN - 1576-7329 VL - 22 IS - 3 PB - Elsevier CY - New York ER - TY - JOUR A1 - Pestryakova, Luidmila Agafyevna A1 - Herzschuh, Ulrike A1 - Gorodnichev, Ruslan A1 - Wetterich, Sebastian T1 - The sensitivity of diatom taxa from Yakutian lakes (north-eastern Siberia) to electrical conductivity and other environmental variables JF - Polar research : a Norwegian journal of Polar research N2 - Relative abundances of 157 diatom taxa from Yakutian lake surface-sediments were investigated for their potential to indicate certain environmental conditions. Data from 206 sites from Arctic, sub-Arctic and boreal environments were included. Redundancy analyses were performed to assess the explanatory power of mean July temperature (T-July), conductivity, pH, dissolved silica concentration, phosphate concentration, lake depth and vegetation type on diatom species composition. Boosted regression tree analyses were performed to infer the most relevant environmental variables for abundances of individual taxa and weighted average regression was applied to infer their respective optimum and tolerance. Electrical conductivity was best indicated by diatom taxa. In contrast, only few taxa were indicative of Si and water depth. Few taxa were related to specific pH values. Although T-July, explained the highest proportion of variance in the diatom spectra and was, after conductivity, the second-most selected splitting variable, we a priori decided not to present indicator taxa because of the poorly understood relationship between diatom occurrences and T-July. In total, 92 diatom taxa were reliable indicators of a certain vegetation type or a combination of several types. The high numbers of indicative species for open vegetation sites and for forested sites suggest that the principal turnover is the transition from forest-tundra to northern taiga. Overall, our results reveal that preference ranges of diatom taxa for environmental variables are mostly broad, and the use of indicator taxa for the purposes of environmental reconstruction or environmental monitoring is therefore restricted to marked rather than subtle environmental transitions. KW - Temperature KW - pH KW - dissolved silica concentration KW - Arctic KW - diatom indicator species Y1 - 2018 U6 - https://doi.org/10.1080/17518369.2018.1485625 SN - 0800-0395 SN - 1751-8369 VL - 37 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Atsawawaranunt, Kamolphat A1 - Comas-Bru, Laia A1 - Mozhdehi, Sahar Amirnezhad A1 - Deininger, Michael A1 - Harrison, Sandy P. A1 - Baker, Andy A1 - Boyd, Meighan A1 - Kaushal, Nikita A1 - Ahmad, Syed Masood A1 - Brahim, Yassine Ait A1 - Arienzo, Monica A1 - Bajo, Petra A1 - Braun, Kerstin A1 - Burstyn, Yuval A1 - Chawchai, Sakonvan A1 - Duan, Wuhui A1 - Hatvani, Istvan Gabor A1 - Hu, Jun A1 - Kern, Zoltan A1 - Labuhn, Inga A1 - Lachniet, Matthew A1 - Lechleitner, Franziska A. A1 - Lorrey, Andrew A1 - Perez-Mejias, Carlos A1 - Pickering, Robyn A1 - Scroxton, Nick A1 - Atkinson, Tim A1 - Ayalon, Avner A1 - Baldini, James A1 - Bar-Matthews, Miriam A1 - Pablo Bernal, Juan A1 - Breitenbach, Sebastian Franz Martin A1 - Boch, Ronny A1 - Borsato, Andrea A1 - Cai, Yanjun A1 - Carolin, Stacy A1 - Cheng, Hai A1 - Columbu, Andrea A1 - Couchoud, Isabelle A1 - Cruz, Francisco A1 - Demeny, Attila A1 - Dominguez-Villar, David A1 - Dragusin, Virgil A1 - Drysdale, Russell A1 - Ersek, Vasile A1 - Finne, Martin A1 - Fleitmann, Dominik A1 - Fohlmeister, Jens Bernd A1 - Frappier, Amy A1 - Genty, Dominique A1 - Holzkamper, Steffen A1 - Hopley, Philip A1 - Kathayat, Gayatri A1 - Keenan-Jones, Duncan A1 - Koltai, Gabriella A1 - Luetscher, Marc A1 - Li, Ting-Yong A1 - Lone, Mahjoor Ahmad A1 - Markowska, Monika A1 - Mattey, Dave A1 - McDermott, Frank A1 - Moreno, Ana A1 - Moseley, Gina A1 - Nehme, Carole A1 - Novello, Valdir F. A1 - Psomiadis, David A1 - Rehfeld, Kira A1 - Ruan, Jiaoyang A1 - Sekhon, Natasha A1 - Sha, Lijuan A1 - Sholz, Denis A1 - Shopov, Yavor A1 - Smith, Andrew A1 - Strikis, Nicolas A1 - Treble, Pauline A1 - Unal-Imer, Ezgi A1 - Vaks, Anton A1 - Vansteenberge, Stef A1 - Veiga-Pires, Cristina A1 - Voarintsoa, Ny Riavo A1 - Wang, Xianfeng A1 - Wong, Corinne A1 - Wortham, Barbara A1 - Wurtzel, Jennifer A1 - Zong, Baoyun T1 - The SISAL database BT - a global resource to document oxygen and carbon isotope records from speleothems JF - Earth System Science Data N2 - Stable isotope records from speleothems provide information on past climate changes, most particularly information that can be used to reconstruct past changes in precipitation and atmospheric circulation. These records are increasingly being used to provide "out-of-sample" evaluations of isotope-enabled climate models. SISAL (Speleothem Isotope Synthesis and Analysis) is an international working group of the Past Global Changes (PAGES) project. The working group aims to provide a comprehensive compilation of speleothem isotope records for climate reconstruction and model evaluation. The SISAL database contains data for individual speleothems, grouped by cave system. Stable isotopes of oxygen and carbon (delta O-18, delta C-13) measurements are referenced by distance from the top or bottom of the speleothem. Additional tables provide information on dating, including information on the dates used to construct the original age model and sufficient information to assess the quality of each data set and to erect a standardized chronology across different speleothems. The metadata table provides location information, information on the full range of measurements carried out on each speleothem and information on the cave system that is relevant to the interpretation of the records, as well as citations for both publications and archived data. Y1 - 2018 U6 - https://doi.org/10.5194/essd-10-1687-2018 SN - 1866-3508 SN - 1866-3516 VL - 10 IS - 3 SP - 1687 EP - 1713 PB - Copernicus CY - Göttingen ER -