TY  - JOUR
A1  - Schwarz, Anja
T1  - Melancholia
JF  - Cultural studies review
Y1  - 2019
U6  - https://doi.org/10.5130/csr.v25i2.6918
SN  - 1837-8692
VL  - 25
IS  - 2
SP  - 259
EP  - 261
PB  - Melbourne Univ. Press
CY  - Sydney
ER  - 
TY  - JOUR
A1  - Ziesemer, Florence
A1  - Hüttel, Alexandra
A1  - Balderjahn, Ingo
T1  - Anti-Consumption
JF  - Sustainability
N2  - Transcending the conventional debate around efficiency in sustainable consumption, anti-consumption patterns leading to decreased levels of material consumption have been gaining importance. Change agents are crucial for the promotion of such patterns, so there may be lessons for governance interventions that can be learnt from the every-day experiences of those who actively implement and promote sustainability in the field of anti-consumption. Eighteen social innovation pioneers, who engage in and diffuse practices of voluntary simplicity and collaborative consumption as sustainable options of anti-consumption share their knowledge and personal insights in expert interviews for this research. Our qualitative content analysis reveals drivers, barriers, and governance strategies to strengthen anti-consumption patterns, which are negotiated between the market, the state, and civil society. Recommendations derived from the interviews concern entrepreneurship, municipal infrastructures in support of local grassroots projects, regulative policy measures, more positive communication to strengthen the visibility of initiatives and emphasize individual benefits, establishing a sense of community, anti-consumer activism, and education. We argue for complementary action between top-down strategies, bottom-up initiatives, corporate activities, and consumer behavior. The results are valuable to researchers, activists, marketers, and policymakers who seek to enhance their understanding of materially reduced consumption patterns based on the real-life experiences of active pioneers in the field.
KW  - social innovation
KW  - sufficiency
KW  - collaborative consumption
KW  - expert interview
KW  - consumer behavior
KW  - sustainability
KW  - innovation policy
KW  - governance for sustainable development
KW  - consumer education
Y1  - 2019
U6  - https://doi.org/10.3390/su11236663
SN  - 2071-1050
VL  - 11
IS  - 23
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Ozcelikay, Goksu
A1  - Kurbanoglu, Sevinc
A1  - Zhang, Xiaorong
A1  - Söz, Çağla Kosak
A1  - Wollenberger, Ulla
A1  - Ozkan, Sibel A.
A1  - Yarman, Aysu
A1  - Scheller, Frieder W.
T1  - Electrochemical MIP Sensor for Butyrylcholinesterase
JF  - Polymers
N2  - Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically relevant enzyme butyrylcholinesterase (BuChE) is presented. The MIP was prepared using electropolymerization of the functional monomer o-phenylenediamine and was deposited as a thin film on a glassy carbon electrode by oxidative potentiodynamic polymerization. Rebinding and removal of the template were detected by cyclic voltammetry using ferricyanide as a redox marker. Furthermore, the enzymatic activity of BuChE rebound to the MIP was measured via the anodic oxidation of thiocholine, the reaction product of butyrylthiocholine. The response was linear between 50 pM and 2 nM concentrations of BuChE with a detection limit of 14.7 pM. In addition to the high sensitivity for BuChE, the sensor responded towards pseudo-irreversible inhibitors in the lower mM range.
KW  - molecularly imprinted polymers
KW  - biomimetic sensors
KW  - butyrylcholinesterase
KW  - o-phenylenediamine
KW  - rivastigmine
Y1  - 2019
U6  - https://doi.org/10.3390/polym11121970
SN  - 2073-4360
VL  - 11
IS  - 12
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Niven, Robert K.
A1  - Abel, Markus
A1  - Schlegel, Michael
A1  - Waldrip, Steven H.
T1  - Maximum Entropy Analysis of Flow Networks: Theoretical Foundation and Applications
JF  - Entropy
N2  - The concept of a "flow network"-a set of nodes and links which carries one or more flows-unites many different disciplines, including pipe flow, fluid flow, electrical, chemical reaction, ecological, epidemiological, neurological, communications, transportation, financial, economic and human social networks. This Feature Paper presents a generalized maximum entropy framework to infer the state of a flow network, including its flow rates and other properties, in probabilistic form. In this method, the network uncertainty is represented by a joint probability function over its unknowns, subject to all that is known. This gives a relative entropy function which is maximized, subject to the constraints, to determine the most probable or most representative state of the network. The constraints can include "observable" constraints on various parameters, "physical" constraints such as conservation laws and frictional properties, and "graphical" constraints arising from uncertainty in the network structure itself. Since the method is probabilistic, it enables the prediction of network properties when there is insufficient information to obtain a deterministic solution. The derived framework can incorporate nonlinear constraints or nonlinear interdependencies between variables, at the cost of requiring numerical solution. The theoretical foundations of the method are first presented, followed by its application to a variety of flow networks.
KW  - maximum entropy analysis
KW  - flow network
KW  - probabilistic inference
Y1  - 2019
U6  - https://doi.org/10.3390/e21080776
SN  - 1099-4300
VL  - 21
IS  - 8
SP  - 776
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schütze, Franziska
A1  - Fürst, Steffen
A1  - Mielke, Jahel
A1  - Steudle, Gesine A.
A1  - Wolf, Sarah
A1  - Jäger, Carlo C.
T1  - The Role of Sustainable Investment in Climate Policy
JF  - Sustainability
N2  - Reaching the Sustainable Development Goals requires a fundamental socio-economic transformation accompanied by substantial investment in low-carbon infrastructure. Such a sustainability transition represents a non-marginal change, driven by behavioral factors and systemic interactions. However, typical economic models used to assess a sustainability transition focus on marginal changes around a local optimum, whichby constructionlead to negative effects. Thus, these models do not allow evaluating a sustainability transition that might have substantial positive effects. This paper examines which mechanisms need to be included in a standard computable general equilibrium model to overcome these limitations and to give a more comprehensive view of the effects of climate change mitigation. Simulation results show that, given an ambitious greenhouse gas emission constraint and a price of carbon, positive economic effects are possible if (1) technical progress results (partly) endogenously from the model and (2) a policy intervention triggering an increase of investment is introduced. Additionally, if (3) the investment behavior of firms is influenced by their sales expectations, the effects are amplified. The results provide suggestions for policy-makers, because the outcome indicates that investment-oriented climate policies can lead to more desirable outcomes in economic, social and environmental terms.
KW  - climate policy
KW  - green growth
KW  - macroeconomic models
KW  - sustainable investment
KW  - technical progress
KW  - expectations
KW  - 1.5 degrees C
Y1  - 2017
U6  - https://doi.org/10.3390/su9122221
SN  - 2071-1050
VL  - 9
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Weisshuhn, Peter
A1  - Reckling, Moritz
A1  - Stachow, Ulrich
A1  - Wiggering, Hubert
T1  - Supporting Agricultural Ecosystem Services through the Integration of Perennial Polycultures into Crop Rotations
JF  - Sustainability
N2  - This review analyzes the potential role and long-term effects of field perennial polycultures (mixtures) in agricultural systems, with the aim of reducing the trade-offs between provisioning and regulating ecosystem services. First, crop rotations are identified as a suitable tool for the assessment of the long-term effects of perennial polycultures on ecosystem services, which are not visible at the single-crop level. Second, the ability of perennial polycultures to support ecosystem services when used in crop rotations is quantified through eight agricultural ecosystem services. Legume-grass mixtures and wildflower mixtures are used as examples of perennial polycultures, and compared with silage maize as a typical crop for biomass production. Perennial polycultures enhance soil fertility, soil protection, climate regulation, pollination, pest and weed control, and landscape aesthetics compared with maize. They also score lower for biomass production compared with maize, which confirms the trade-off between provisioning and regulating ecosystem services. However, the additional positive factors provided by perennial polycultures, such as reduced costs for mineral fertilizer, pesticides, and soil tillage, and a significant preceding crop effect that increases the yields of subsequent crops, should be taken into account. However, a full assessment of agricultural ecosystem services requires a more holistic analysis that is beyond the capabilities of current frameworks.
KW  - agroecosystem
KW  - assessment
KW  - legume-grass mixture
KW  - wildflower mixture
KW  - perennial crop
KW  - mixed cropping
Y1  - 2017
U6  - https://doi.org/10.3390/su9122267
SN  - 2071-1050
VL  - 9
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Posovszky, Carsten
A1  - Roesler, Vreni Helen
A1  - Becker, Sebastian
A1  - Iven, Enno
A1  - Hudert, Christian
A1  - Ebinger, Friedrich
A1  - Calvano, Claudia
A1  - Warschburger, Petra
T1  - Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain
JF  - Nutrients
N2  - Intolerance to lactose or fructose is frequently diagnosed in children with chronic abdominal pain (CAP). However, the causal relationship remains a matter of discussion. A cohort of 253 patients, aged 7-12 years, presenting with unexplained CAP received standardized diagnostics. Additional diagnostic tests were performed based on their medical history and physical and laboratory investigations. Fructose and lactose hydrogen breath tests (H2BT) as well as empiric diagnostic elimination diets were performed in 135 patients reporting abdominal pain related to the consumption of lactose or fructose to evaluate carbohydrate intolerance as a potential cause of CAP. Carbohydrate malabsorption by H2BT was found in 55 (41%) out of 135 patients. An abnormal increase in H2BT was revealed in 30% (35/118) of patients after fructose consumption and in 18% (20/114) of patients after lactose administration. Forty-six percent (25/54) reported pain relief during a diagnostic elimination diet. In total, 17 patients had lactose malabsorption, 29 fructose malabsorption, and nine combined carbohydrate malabsorption. Carbohydrate intolerance as a cause of CAP was diagnosed at follow-up in only 18% (10/55) of patients with malabsorption after the elimination of the respective carbohydrate. Thus, carbohydrate malabsorption appears to be an incidental finding in children with functional abdominal pain disorders, rather than its cause. Therefore, testing of carbohydrate intolerance should only be considered in children with a strong clinical suspicion and with the goal to prevent long-term unnecessary dietary restrictions in children suffering from CAP.
KW  - chronic abdominal pain
KW  - children
KW  - fructose malabsorption
KW  - lactose intolerance
KW  - hydrogen breath test
KW  - functional abdominal pain disorders
Y1  - 2019
U6  - https://doi.org/10.3390/nu11123063
SN  - 2072-6643
VL  - 11
IS  - 12
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Codutti, Agnese
A1  - Bente, Klaas
A1  - Faivre, Damien
A1  - Klumpp, Stefan
T1  - Chemotaxis in external fields: Simulations for active magnetic biological matter
JF  - PLoS Computational Biology : a new community journal
N2  - The movement of microswimmers is often described by active Brownian particle models. Here we introduce a variant of these models with several internal states of the swimmer to describe stochastic strategies for directional swimming such as run and tumble or run and reverse that are used by microorganisms for chemotaxis. The model includes a mechanism to generate a directional bias for chemotaxis and interactions with external fields (e.g., gravity, magnetic field, fluid flow) that impose forces or torques on the swimmer. We show how this modified model can be applied to various scenarios: First, the run and tumble motion of E. coli is used to establish a paradigm for chemotaxis and investigate how it is affected by external forces. Then, we study magneto-aerotaxis in magnetotactic bacteria, which is biased not only by an oxygen gradient towards a preferred concentration, but also by magnetic fields, which exert a torque on an intracellular chain of magnets. We study the competition of magnetic alignment with active reorientation and show that the magnetic orientation can improve chemotaxis and thereby provide an advantage to the bacteria, even at rather large inclination angles of the magnetic field relative to the oxygen gradient, a case reminiscent of what is expected for the bacteria at or close to the equator. The highest gain in chemotactic velocity is obtained for run and tumble with a magnetic field parallel to the gradient, but in general a mechanism for reverse motion is necessary to swim against the magnetic field and a run and reverse strategy is more advantageous in the presence of a magnetic torque. This finding is consistent with observations that the dominant mode of directional changes in magnetotactic bacteria is reversal rather than tumbles. Moreover, it provides guidance for the design of future magnetic biohybrid swimmers. Author summary In this paper, we propose a modified Active Brownian particle model to describe bacterial swimming behavior under the influence of external forces and torques, in particular of a magnetic torque. This type of interaction is particularly important for magnetic biohybrids (i.e. motile bacteria coupled to a synthetic magnetic component) and for magnetotactic bacteria (i.e. bacteria with a natural intracellular magnetic chain), which perform chemotaxis to swim along chemical gradients, but are also directed by an external magnetic field. The model allows us to investigate the benefits and disadvantages of such coupling between two different directionality mechanisms. In particular we show that the magnetic torque can speed chemotaxis up in some conditions, while it can hinder it in other cases. In addition to an understanding of the swimming strategies of naturally magnetotactic organisms, the results may guide the design of future biomedical devices.
Y1  - 2019
U6  - https://doi.org/10.1371/journal.pcbi.1007548
SN  - 1553-734X
SN  - 1553-7358
VL  - 15
IS  - 12
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Wong, Kevin
A1  - Mason, Emily
A1  - Brune, Sascha
A1  - East, Madison
A1  - Edmonds, Marie
A1  - Zahirovic, Sabin
T1  - Deep Carbon Cycling Over the Past 200 Million Years: A Review of Fluxes in Different Tectonic Settings
JF  - Frontiers in Earth Science
KW  - deep carbon cycle
KW  - carbonate assimilation
KW  - solid Earth degassing
KW  - plate reconstructions
KW  - carbon dioxide
KW  - subduction zone
Y1  - 2019
U6  - https://doi.org/10.3389/feart.2019.00263
SN  - 2296-6463
VL  - 7
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Mei, Shilin
A1  - Kochovski, Zdravko
A1  - Roa, Rafael
A1  - Gu, Sasa
A1  - Xu, Xiaohui
A1  - Yu, Hongtao
A1  - Dzubiella, Joachim
A1  - Ballauff, Matthias
A1  - Lu, Yan
T1  - Enhanced Catalytic Activity of Gold@Polydopamine Nanoreactors with Multi-compartment Structure Under NIR Irradiation
JF  - Nano-Micro Letters
N2  - Photothermal conversion (PTC) nanostructures have great potential for applications in many fields, and therefore, they have attracted tremendous attention. However, the construction of a PTC nanoreactor with multi-compartment structure to achieve the combination of unique chemical properties and structural feature is still challenging due to the synthetic difficulties. Herein, we designed and synthesized a catalytically active, PTC gold (Au)@polydopamine (PDA) nanoreactor driven by infrared irradiation using assembled PS-b-P2VP nanosphere as soft template. The particles exhibit multi-compartment structure which is revealed by 3D electron tomography characterization technique. They feature permeable shells with tunable shell thickness. Full kinetics for the reduction reaction of 4-nitrophenol has been investigated using these particles as nanoreactors and compared with other reported systems. Notably, a remarkable acceleration of the catalytic reaction upon near-infrared irradiation is demonstrated, which reveals for the first time the importance of the synergistic effect of photothermal conversion and complex inner structure to the kinetics of the catalytic reduction. The ease of synthesis and fresh insights into catalysis will promote a new platform for novel nanoreactor studies.
KW  - Gold@polydopamine
KW  - 3D tomography
KW  - Nanoreactor
KW  - Catalysis
KW  - Photothermal conversion
Y1  - 2019
U6  - https://doi.org/10.1007/s40820-019-0314-9
SN  - 2311-6706
SN  - 2150-5551
VL  - 11
IS  - 1
PB  - Shanghai JIAO TONG univ press
CY  - Shanghai
ER  - 
TY  - JOUR
A1  - Saha, Sourav
A1  - Owen, Lewis A.
A1  - Orr, Elizabeth N.
A1  - Caffee, Marc W.
T1  - Cosmogenic Be-10 and equilibrium-line altitude dataset of Holocene glacier advances in the Himalayan-Tibetan orogen
JF  - Data in brief
N2  - A comprehensive analysis of the variable temporal and spatial responses of tropical-subtropical high-altitude glaciers to climate change is critical for successful model predictions and environmental risk assessment in the Himalayan-Tibetan orogen. High-frequency Holocene glacier chronostratigraphies are therefore reconstructed in 79 glaciated valleys across the orogen using 519 published and 16 new terrestrial cosmogenic 10Be exposure age dataset. Published 10Be ages are compiled only for moraine boulders (excluding bedrock ages). These ages are recalculated using the latest ICE-D production rate calibration database and the scaling scheme models. Outliers for the individual moraine are detected using the Chauvenet's criterion. In addition, past equilibrium-line altitudes (ELAs) are determined using the area-altitude (AA), area accumulation ratio (AAR), and toe-headwall accumulation ratio (THAR) methods for each glacier advance. The modern maximum elevations of lateral moraines (MELM) are also used to estimate modern ELAs and as an independent check on mean ELAs derived using the above three methods. These data may serve as an essential archive for future studies focusing on the cryospheric and environmental changes in the Himalayan-Tibetan orogen. A more comprehensive analysis of the published and new 10Be ages and ELA results and a list of references are presented in Saha et al. (2019, High-frequency Holocene glacier fluctuations in the Himalayan-Tibetan orogen. Quaternary Science Reviews, 220, 372–400).
KW  - Cosmogenic nuclides
KW  - Equilibrium-line altitudes
KW  - Holocene
KW  - Central asia
KW  - Glaciation
Y1  - 2019
U6  - https://doi.org/10.1016/j.dib.2019.104412
SN  - 2352-3409
VL  - 26
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Rossberg, Axel G.
A1  - Gaedke, Ursula
A1  - Kratina, Pavel
T1  - Dome patterns in pelagic size spectra reveal strong trophic cascades
JF  - Nature Communications
N2  - In ecological communities, especially the pelagic zones of aquatic ecosystems, certain bodysize ranges are often over-represented compared to others. Community size spectra, the distributions of community biomass over the logarithmic body-mass axis, tend to exhibit regularly spaced local maxima, called "domes", separated by steep troughs. Contrasting established theory, we explain these dome patterns as manifestations of top-down trophic cascades along aquatic food chains. Compiling high quality size-spectrum data and comparing these with a size-spectrum model introduced in this study, we test this theory and develop a detailed picture of the mechanisms by which bottom-up and top-down effects interact to generate dome patterns. Results imply that strong top-down trophic cascades are common in freshwater communities, much more than hitherto demonstrated, and may arise in nutrient rich marine systems as well. Transferring insights from the general theory of nonlinear pattern formation to domes patterns, we provide new interpretations of past lake-manipulation experiments.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-12289-0
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Franz, Kristina
A1  - Otten, Lindsey
A1  - Müller-Werdan, Ursula
A1  - Döhner, Wolfram
A1  - Norman, Kristina
T1  - Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital
JF  - Nutrients
N2  - Although malnutrition is frequent in the old, little is known about its association with fatigue. We evaluated the relation of self-reported severe weight loss with fatigue and the predictors for fatigue in old patients at hospital discharge. Severe weight loss was defined according to involuntary weight loss >= 5% in the last three months. We determined fatigue with the validated Brief Fatigue Inventory questionnaire. The regression analyses were adjusted for age, sex, number of comorbidities, medications/day, and BMI. Of 424 patients aged between 61 and 98 y, 34.1% had severe weight loss. Fatigue was higher in patients with severe weight loss (3.7 +/- 2.3 vs. 3.2 +/- 2.3 points, p = 0.021). In a multinomial regression model, weight loss was independently associated with higher risk for moderate fatigue (OR:1.172, CI:1.026-1.338, p = 0.019) and with increased risk for severe fatigue (OR:1.209, CI:1.047-1.395, p = 0.010) together with the number of medications/day (OR:1.220, CI:1.023-1.455, p = 0.027). In a binary regression model, severe weight loss predicted moderate-to-severe fatigue in the study population (OR:1.651, CI:1.052-2.590, p = 0.029). In summary, patients with self-reported severe weight loss at hospital discharge exhibited higher fatigue levels and severe weight loss was an independent predictor of moderate and severe fatigue, placing these patients at risk for impaired outcome in the post-hospital period.
KW  - malnutrition
KW  - involuntary weight loss
KW  - post-hospital syndrome
KW  - fatigue
KW  - old adults
Y1  - 2019
U6  - https://doi.org/10.3390/nu11102415
SN  - 2072-6643
VL  - 11
IS  - 10
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Palyulin, Vladimir V.
A1  - Blackburn, George
A1  - Lomholt, Michael A.
A1  - Watkins, Nicholas W.
A1  - Metzler, Ralf
A1  - Klages, Rainer
A1  - Chechkin, Aleksei V.
T1  - First passage and first hitting times of Levy flights and Levy walks
JF  - New journal of physics : the open-access journal for physics
N2  - For both Lévy flight and Lévy walk search processes we analyse the full distribution of first-passage and first-hitting (or first-arrival) times. These are, respectively, the times when the particle moves across a point at some given distance from its initial position for the first time, or when it lands at a given point for the first time. For Lévy motions with their propensity for long relocation events and thus the possibility to jump across a given point in space without actually hitting it ('leapovers'), these two definitions lead to significantly different results. We study the first-passage and first-hitting time distributions as functions of the Lévy stable index, highlighting the different behaviour for the cases when the first absolute moment of the jump length distribution is finite or infinite. In particular we examine the limits of short and long times. Our results will find their application in the mathematical modelling of random search processes as well as computer algorithms.
KW  - Levy flights
KW  - Levy walks
KW  - first-passage time
KW  - first-hitting time
Y1  - 2019
U6  - https://doi.org/10.1088/1367-2630/ab41bb
SN  - 1367-2630
VL  - 21
IS  - 10
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Matthey-Doret, Cyril
A1  - van der Kooi, Casper J.
A1  - Jeffries, Daniel L.
A1  - Bast, Jens
A1  - Dennis, Alice B.
A1  - Vorburger, Christoph
A1  - Schwander, Tanja
T1  - Mapping of Multiple Complementary Sex Determination Loci in a Parasitoid Wasp
JF  - Genome biology and evolution
N2  - Sex determination has evolved in a variety of ways and can depend on environmental and genetic signals. A widespread form of genetic sex determination is haplodiploidy, where unfertilized, haploid eggs develop into males and fertilized diploid eggs into females. One of the molecular mechanisms underlying haplodiploidy in Hymenoptera, the large insect order comprising ants, bees, and wasps, is complementary sex determination (CSD). In species with CSD, heterozygosity at one or several loci induces female development. Here, we identify the genomic regions putatively underlying multilocus CSD in the parasitoid wasp Lysiphlebus fabarum using restriction -site associated DNA sequencing. By analyzing segregation patterns at polymorphic sites among 331 diploid males and females, we identify up to four CSD candidate regions, all on different chromosomes. None of the candidate regions feature evidence for homology with the csd gene from the honey bee, the only species in which CSD has been characterized, suggesting that CSD in L. fabarum is regulated via a novel molecular mechanism. Moreover, no homology is shared between the candidate loci, in contrast to the idea that multilocus CSD should emerge from duplications of an ancestral single -locus system. Taken together, our results suggest that the molecular mechanisms underlying CSD in Hymenoptera are not conserved between species, raising the question as to whether CSD may have evolved multiple times independently in the group.
KW  - hymenoptera
KW  - sex determination
KW  - Lysiphlebus fabarum
KW  - CSD
Y1  - 2019
U6  - https://doi.org/10.1093/gbe/evz219
SN  - 1759-6653
VL  - 11
IS  - 10
SP  - 2954
EP  - 2962
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Felser, Claudia
A1  - Jessen, Anna
T1  - Correlative coordination and variable subject-verb agreement in German
JF  - Languages : open access journal
N2  - Coordinated subjects often show variable number agreement with the finite verb, but linguistic approaches to this phenomenon have rarely been informed by systematically collected data. We report the results from three experiments investigating German speakers' agreement preferences with complex subjects joined by the correlative conjunctions sowohl horizontal ellipsis als auch ('both horizontal ellipsis and'), weder horizontal ellipsis noch ('neither horizontal ellipsis nor') or entweder horizontal ellipsis oder ('either horizontal ellipsis or'). We examine to what extent conjunction type and a conjunct's relative proximity to the verb affect the acceptability and processibility of singular vs. plural agreement. Experiment 1 was an untimed acceptability rating task, Experiment 2 a timed sentence completion task, and Experiment 3 was a self-paced reading task. Taken together, our results show that number agreement with correlative coordination in German is primarily determined by a default constraint triggering plural agreement, which interacts with linear order and semantic factors. Semantic differences between conjunctions only affected speakers' agreement preferences in the absence of processing pressure but not their initial agreement computation. The combined results from our offline and online experimental measures of German speakers' agreement preferences suggest that the constraints under investigation do not only differ in their relative weighting but also in their relative timing during agreement computation.
KW  - correlative coordination
KW  - subject– verb agreement
KW  - German
Y1  - 2021
U6  - https://doi.org/10.3390/languages6020067
SN  - 2226-471X
VL  - 6
IS  - 2
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Tofelde, Stefanie
A1  - Bufe, Aaron
A1  - Turowski, Jens M.
T1  - Hillslope Sediment Supply Limits Alluvial Valley Width
JF  - AGU Advances
N2  - River-valley morphology preserves information on tectonic and climatic conditions that shape landscapes. Observations suggest that river discharge and valley-wall lithology are the main controls on valley width. Yet, current models based on these observations fail to explain the full range of cross-sectional valley shapes in nature, suggesting hitherto unquantified controls on valley width. In particular, current models cannot explain the existence of paired terrace sequences that form under cyclic climate forcing. Paired river terraces are staircases of abandoned floodplains on both valley sides, and hence preserve past valley widths. Their formation requires alternating phases of predominantly river incision and predominantly lateral planation, plus progressive valley narrowing. While cyclic Quaternary climate changes can explain shifts between incision and lateral erosion, the driving mechanism of valley narrowing is unknown. Here, we extract valley geometries from climatically formed, alluvial river-terrace sequences and show that across our dataset, the total cumulative terrace height (here: total valley height) explains 90%–99% of the variance in valley width at the terrace sites. This finding suggests that valley height, or a parameter that scales linearly with valley height, controls valley width in addition to river discharge and lithology. To explain this valley-width-height relationship, we reformulate existing valley-width models and suggest that, when adjusting to new boundary conditions, alluvial valleys evolve to a width at which sediment removal from valley walls matches lateral sediment supply from hillslope erosion. Such a hillslope-channel coupling is not captured in current valley-evolution models. Our model can explain the existence of paired terrace sequences under cyclic climate forcing and relates valley width to measurable field parameters. Therefore, it facilitates the reconstruction of past climatic and tectonic conditions from valley topography.
Y1  - 2022
U6  - https://doi.org/10.1029/2021AV000641
SN  - 2576-604X
PB  - American Geophysical Union (AGU); Wiley
CY  - Hoboken, New Jersey, USA
ER  - 
TY  - JOUR
A1  - Kühne, Franziska
A1  - Paunov, Tatjana
A1  - Weck, Florian
T1  - Recognizing obsessive-compulsive disorder
BT  - How suitable is the German Zohar-Fineberg obsessive-compulsive screen?
JF  - BMC psychiatry
N2  - Background 
Despite the prevalence of obsessive-compulsive disorder (OCD), its precise identification remains challenging. With the Zohar-Fineberg Obsessive-Compulsive Screen (ZF-OCS; 5 or 6 items), a brief instrument is widely available mainly in English. As there is a lack of empirical studies on the ZF-OCS, the aim of the present study was to translate the items into German and investigate the instrument in a nonclinical sample. 

Methods 
In two consecutive online surveys, n = 304 and n = 51 students participated. Besides the ZF-OCS, they answered established measures on OCD, depression, health anxiety, general anxiety and health-related well-being.  

Results 
Whereas internal consistency was low (α = .53–.72; ω = .55–.69), retest reliability (rt1,t2 = .89) at two weeks was high. As expected, we found high correlations with other OCD instruments (r > .61; convergent validity), and significantly weaker correlations with measures of depression (r = .39), health anxiety (r = .29), and health-related well-being (r = −.28, divergent validity). Nonetheless, the correlations with general anxiety were somewhere in between (r = .52).

Conclusions 
Due to heterogeneous OCD subtypes, the ZF-OCS asks diverse questions which probably resulted in the present internal consistency. Nevertheless, the results on retest reliability and validity were promising. As for other OCD instruments, divergent validity regarding general anxiety seems problematic to establish. Even so, the ZF-OCS seems valuable for screening purposes, as it is short and easy to administer, and may facilitate initiating subsequent clinical assessment. Further studies should determine the instrument’s diagnostic accuracy.
KW  - Obsessive-compulsive disorder
KW  - Psychodiagnostics
KW  - Psychometric properties
KW  - Screening
Y1  - 2021
U6  - https://doi.org/10.1186/s12888-021-03458-x
SN  - 1471-244X
VL  - 21
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Park, Jaeheung
A1  - Stolle, Claudia
A1  - Yamazaki, Yosuke
A1  - Rauberg, Jan
A1  - Michaelis, Ingo
A1  - Olsen, Nils
T1  - Diagnosing low-/mid-latitude ionospheric currents using platform magnetometers
BT  - CryoSat-2 and GRACE-FO
JF  - Earth, planets and space
N2  - Electric currents flowing in the terrestrial ionosphere have conventionally been diagnosed by low-earth-orbit (LEO) satellites equipped with science-grade magnetometers and long booms on magnetically clean satellites. In recent years, there are a variety of endeavors to incorporate platform magnetometers, which are initially designed for navigation purposes, to study ionospheric currents. Because of the suboptimal resolution and significant noise of the platform magnetometers, however, most of the studies were confined to high-latitude auroral regions, where magnetic field deflections from ionospheric currents easily exceed 100 nT. This study aims to demonstrate the possibility of diagnosing weak low-/mid-latitude ionospheric currents based on platform magnetometers. We use navigation magnetometer data from two satellites, CryoSat-2 and the Gravity Recovery and Climate Experiment Follow-On (GRACE-FO), both of which have been intensively calibrated based on housekeeping data and a high-precision geomagnetic field model. Analyses based on 8 years of CryoSat-2 data as well as similar to 1.5 years of GRACE-FO data reproduce well-known climatology of inter-hemispheric field-aligned currents (IHFACs), as reported by previous satellite missions dedicated to precise magnetic observations. Also, our results show that C-shaped structures appearing in noontime IHFAC distributions conform to the shape of the South Atlantic Anomaly. The F-region dynamo currents are only partially identified in the platform magnetometer data, possibly because the currents are weaker than IHFACs in general and depend significantly on altitude and solar activity. Still, this study evidences noontime F-region dynamo currents at the highest altitude (717 km) ever reported. We expect that further data accumulation from continuously operating missions may reveal the dynamo currents more clearly during the next solar maximum.
KW  - Platform magnetometers
KW  - CryoSat-2
KW  - GRACE-FO
KW  - Inter-hemispheric
KW  - field-aligned currents
KW  - F-region dynamo currents
Y1  - 2020
U6  - https://doi.org/10.1186/s40623-020-01274-3
SN  - 1343-8832
SN  - 1880-5981
VL  - 72
IS  - 1
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Miklashevsky, Alex
A1  - Fischer, Martin H.
A1  - Lindemann, Oliver
T1  - Spatial-numerical associations without a motor response? Grip force says ‘Yes’
JF  - Acta Psychologica
N2  - In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task (“Is it a number or a letter?”). In Experiment 2, we used a deeper semantic task (“Is this number larger or smaller than five?”). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500–700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words).
KW  - SNARC
KW  - Mental number line
KW  - Number processing
KW  - Embodied cognition
KW  - Grip force
KW  - Motor system
Y1  - 2022
U6  - https://doi.org/10.1016/j.actpsy.2022.103791
SN  - 1873-6297
VL  - 231
SP  - 1
EP  - 17
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Drago, Claudia
A1  - Pawlak, Julia
A1  - Weithoff, Guntram
T1  - Biogenic aggregation of small microplastics alters their ingestion by a common freshwater micro-invertebrate
JF  - Frontiers in Environmental Science
N2  - In recent years, increasing concerns have been raised about the environmental risk of microplastics in freshwater ecosystems. Small microplastics enter the water either directly or accumulate through disintegration of larger plastic particles. These particles might then be ingested by filter-feeding zooplankton, such as rotifers. Particles released into the water may also interact with the biota through the formation of aggregates, which might alter the uptake by zooplankton. In this study, we tested for size-specific aggregation of polystyrene microspheres and their ingestion by a common freshwater rotifer Brachionus calyciflorus. The ingestion of three sizes of polystyrene microspheres (MS) 1-, 3-, and 6-mu m was investigated. Each MS size was tested in combination with three different treatments: MS as the sole food intake, MS in association with food algae and MS aggregated with biogenic matter. After 72 h incubation in pre-filtered natural river water, the majority of the 1-mu m spheres occurred as aggregates. The larger the particles, the higher the relative number of single particles and the larger the aggregates. All particles were ingested by the rotifer following a Type-II functional response. The presence of algae did not influence the ingestion of the MS for all three sizes. The biogenic aggregation of microspheres led to a significant size-dependent alteration in their ingestion. Rotifers ingested more microspheres (MS) when exposed to aggregated 1- and 3-mu m MS as compared to single spheres, whereas fewer aggregated 6-mu m spheres were ingested. This indicates that the small particles when aggregated were in an effective size range for Brachionus, while the aggregated larger spheres became too large to be efficiently ingested. These observations provide the first evidence of a size- and aggregation-dependent feeding interaction between microplastics and rotifers. Microplastics when aggregated with biogenic particles in a natural environment can rapidly change their size-dependent availability. The aggregation properties of microplastics should be taken into account when performing experiments mimicking the natural environment.
KW  - microplastics ingestion
KW  - Brachionus calyciflorus
KW  - aggregation
KW  - microplastics
KW  - polystyrene
KW  - functional response
Y1  - 2020
U6  - https://doi.org/10.3389/fenvs.2020.574274
SN  - 2296-665X
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Lindner, Nadja
A1  - Moeller, Korbinian
A1  - Hildebrandt, Frauke
A1  - Hasselhorn, Marcus
A1  - Lonnemann, Jan
T1  - Children's use of egocentric reference frames in spatial language is related to their numerical magnitude understanding
JF  - Frontiers in Psychology
N2  - Numerical magnitude information is assumed to be spatially represented in the form of a mental number line defined with respect to a body-centred, egocentric frame of reference. In this context, spatial language skills such as mastery of verbal descriptions of spatial position (e.g., in front of, behind, to the right/left) have been proposed to be relevant for grasping spatial relations between numerical magnitudes on the mental number line. We examined 4- to 5-year-old’s spatial language skills in tasks that allow responses in egocentric and allocentric frames of reference, as well as their relative understanding of numerical magnitude (assessed by a number word comparison task). In addition, we evaluated influences of children’s absolute understanding of numerical magnitude assessed by their number word comprehension (montring different numbers using their fingers) and of their knowledge on numerical sequences (determining predecessors and successors as well as identifying missing dice patterns of a series). Results indicated that when considering responses that corresponded to the egocentric perspective, children’s spatial language was associated significantly with their relative numerical magnitude understanding, even after controlling for covariates, such as children’s SES, mental rotation skills, and also absolute magnitude understanding or knowledge on numerical sequences. This suggests that the use of egocentric reference frames in spatial language may facilitate spatial representation of numbers along a mental number line and thus seem important for preschoolers’ relative understanding of numerical magnitude.
KW  - spatial language
KW  - frames of reference
KW  - numerical development
KW  - mental number line
KW  - preschool children
Y1  - 2022
U6  - https://doi.org/10.3389/fpsyg.2022.943191
SN  - 1664-1078
SP  - 1
EP  - 13
PB  - Frontiers
CY  - Lausanne, Schweiz
ER  - 
TY  - JOUR
A1  - Ogunkola, Moses Olalekan
A1  - Guiraudie-Capraz, Gaelle
A1  - Féron, François
A1  - Leimkühler, Silke
T1  - The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells
JF  - Biomolecules
N2  - Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the human mercaptopyruvate sulfurtransferase (MPST) also designated as tRNA thiouridine modification protein (TUM1). The role of the human TUM1 protein has been suggested in a wide range of physiological processes in the cell among which are but not limited to involvement in Molybdenum cofactor (Moco) biosynthesis, cytosolic tRNA thiolation and generation of H2S as signaling molecule both in mitochondria and the cytosol. Previous interaction studies showed that TUM1 interacts with the L-cysteine desulfurase NFS1 and the Molybdenum cofactor biosynthesis protein 3 (MOCS3). Here, we show the roles of TUM1 in human cells using CRISPR/Cas9 genetically modified Human Embryonic Kidney cells. Here, we show that TUM1 is involved in the sulfur transfer for Molybdenum cofactor synthesis and tRNA thiomodification by spectrophotometric measurement of the activity of sulfite oxidase and liquid chromatography quantification of the level of sulfur-modified tRNA. Further, we show that TUM1 has a role in hydrogen sulfide production and cellular bioenergetics.
KW  - Moco biosynthesis
KW  - sulfite oxidase
KW  - cytosolic tRNA thiolation
KW  - 5-methoxycarbonylmethyl-2-thiouridine
KW  - H2S biosynthesis
KW  - cellular bioenergetics
Y1  - 2023
U6  - https://doi.org/10.3390/biom13010144
SN  - 2218-273X
VL  - 13
SP  - 1
EP  - 23
PB  - MDPI
CY  - Basel, Schweiz
ET  - 1
ER  - 
TY  - BOOK
A1  - Bender, Carsten
A1  - Dreiack, Stefanie
A1  - Engels, Victoria
A1  - Fisseler, Björn
A1  - Gregory, Luisa
A1  - Gross, Monika
A1  - Kaffenberger, Jens
A1  - Kostädt, Peter
A1  - Meyer zu Bexten, Erdmuthe
A1  - Rustemeier, Linda
A1  - Schwarz, Thorsten
A1  - Tannert, Benjamin
A1  - Velasquez, Estefania Cepeda
A1  - Weber, Gerhard
T1  - Leitfaden zur Digitalen Barrierefreiheit im Hochschulkontext
T3  - Arbeitspapier / Hochschulforum Digitalisierung (HFD) ; 66
Y1  - 2022
U6  - https://doi.org/10.5445/IR/1000153177
SN  - 2365-7081
VL  - 5
PB  - Stifterverband für die Deutsche Wissenschaft
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bertelmann, Roland
A1  - Mittermaier, Bernhard
A1  - Kostädt, Peter
T1  - Transform2Open
BT  - Kostenmonitoring, Kriterien, Kompetenzen und Prozesse der Open-Access-Transformation
Y1  - 2022
U6  - https://doi.org/10.48440/os.helmholtz.054
PB  - Helmholtz Open Science Office
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Rezori, Roman Enzio von
A1  - Buchallik, Friederike
A1  - Warschburger, Petra
T1  - Validation of the German Benefit Finding Scale for youth with chronic conditions
JF  - Child and adolescent psychiatry and mental health
N2  - Background
Benefit finding, defined as perceiving positive life changes resulting from adversity and negative life stressors, gains growing attention in the context of chronic illness. The study aimed at examining the psychometric properties of the Benefit Finding Scale for Children (BFSC) in a sample of German youth facing chronic conditions.

Methods
A sample of adolescents with various chronic conditions (N = 304; 12 – 21years) completed the 10-item BFSC along with measures of intra- and interpersonal resources, coping strategies, and health-related quality of life (hrQoL). The total sample was randomly divided into two subsamples for conducting exploratory and confirmatory factor analyses (EFA/CFA).

Results
EFA revealed that the BFSC scores had a one-dimensional factor structure. CFA verified the one-dimensional factor structure with an acceptable fit. The BFSC exhibited acceptable internal consistency (α = 0.87 – 0.88) and construct validity. In line with our hypotheses, benefit finding was positively correlated with optimism, self-esteem, self-efficacy, sense of coherence, and support seeking. There were no correlations with avoidance, wishful thinking, emotional reaction, and hrQoL. Sex differences in benefit finding were not consistent across subsamples. Benefit finding was also positively associated with age, disease severity, and social status.

Conclusions
The BFSC is a psychometrically sound instrument to assess benefit finding in adolescents with chronic illness and may facilitate further research on positive adaptation processes in adolescents, irrespective of their specific diagnosis.
KW  - Measure validation
KW  - Chronic conditions
KW  - Resilience
KW  - Coping skills and adjustment
KW  - Youth
Y1  - 2022
U6  - https://doi.org/10.1186/s13034-021-00438-7
SN  - 1753-2000
VL  - 16
SP  - 1
EP  - 8
PB  - Biomed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Marggraf, Lara Christin
A1  - Lindecke, Oliver
A1  - Voigt, Christian C.
A1  - Pētersons, Gunārs
A1  - Voigt-Heucke, Silke Luise
T1  - Nathusius’ bats, Pipistrellus nathusii, bypass mating opportunities of their own species, but respond to foraging heterospecifics on migratory transit flights
JF  - Frontiers in Ecology and Evolution
N2  - In late summer, migratory bats of the temperate zone face the challenge of accomplishing two energy-demanding tasks almost at the same time: migration and mating. Both require information and involve search efforts, such as localizing prey or finding potential mates. In non-migrating bat species, playback studies showed that listening to vocalizations of other bats, both con-and heterospecifics, may help a recipient bat to find foraging patches and mating sites. However, we are still unaware of the degree to which migrating bats depend on con-or heterospecific vocalizations for identifying potential feeding or mating opportunities during nightly transit flights. Here, we investigated the vocal responses of Nathusius’ pipistrelle bats, Pipistrellus nathusii, to simulated feeding and courtship aggregations at a coastal migration corridor. We presented migrating bats either feeding buzzes or courtship calls of their own or a heterospecific migratory species, the common noctule, Nyctalus noctula. We expected that during migratory transit flights, simulated feeding opportunities would be particularly attractive to bats, as well as simulated mating opportunities which may indicate suitable roosts for a stopover. However, we found that when compared to the natural silence of both pre-and post-playback phases, bats called indifferently during the playback of conspecific feeding sounds, whereas P. nathusii echolocation call activity increased during simulated feeding of N. noctula. In contrast, the call activity of P. nathusii decreased during the playback of conspecific courtship calls, while no response could be detected when heterospecific call types were broadcasted. Our results suggest that while on migratory transits, P. nathusii circumnavigate conspecific mating aggregations, possibly to save time or to reduce the risks associated with social interactions where aggression due to territoriality might be expected. This avoidance behavior could be a result of optimization strategies by P. nathusii when performing long-distance migratory flights, and it could also explain the lack of a response to simulated conspecific feeding. However, the observed increase of activity in response to simulated feeding of N. noctula, suggests that P. nathusii individuals may be eavesdropping on other aerial hawking insectivorous species during migration, especially if these occupy a slightly different foraging niche.
KW  - playback
KW  - phonotaxis
KW  - bats
KW  - acoustic communication
KW  - animal migration
KW  - eavesdropping
KW  - echolocation
KW  - Pipistrellus nathusii
Y1  - 2023
U6  - https://doi.org/10.3389/fevo.2022.908560
SN  - 2296-701X
SP  - 1
EP  - 10
PB  - Frontiers
CY  - Lausanne, Schweiz
ER  - 
TY  - JOUR
A1  - Dörfler, Thomas
T1  - Die Sanktionsausschüsse zwischen Macht und Regeln
T1  - Sanctions Committees Caught between Power and Rules
JF  - Vereinte Nationen : Zeitschrift für die Vereinten Nationen und ihre Sonderorganisationen
N2  - Sanktionen sind ein wichtiges Instrument des UN-Sicherheitsrats zur Erhaltung des Weltfriedens. Viele zentrale Entscheidungen, wie etwa die Listung und Entlistung terrorverdächtiger Personen, werden fernab der Öffentlichkeit in Sanktionsausschüssen getroffen. Die Einsetzung dieser Ausschüsse hat die Entscheidungsdynamiken im Rat erheblich verändert.
N2  - Sanctions are an important instrument of the United Nations Security Council to maintain international peace and security. The Council, however, transfers many decisions, such as the listing and delisting of individuals suspected of supporting terrorism, to its subsidiary sanctions
committees, mostly beyond public scrutiny. The article explores, how the creation of sanctions committees has changed decision-making dynamics, how committee members can be committed to rules and what this might imply for Germany’s future role on the Council.
KW  - Al-Qaida
KW  - Iran
KW  - Sanktionen
KW  - Sicherheitsrat
KW  - Sudan
KW  - UN Security Council
KW  - Terrorismus
KW  - sanctions committee
Y1  - 2018
SN  - 0042-384X
SN  - 2366-6773
VL  - 66
IS  - 2
SP  - 62
EP  - 66
PB  - BWV
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kühne, Franziska
A1  - Fauth, Henriette
A1  - Destina Sevde, Ay-Bryson
A1  - Visser, Leonie N.C.
A1  - Weck, Florian
T1  - Communicating the diagnosis of cancer or depression: Results of a randomized controlled online study using video vignettes
JF  - Cancer Medicine
N2  - Background
Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study.

Methods
Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied.

Results
Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61–1.06). 

Conclusions
The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer.
KW  - consultation
KW  - mental health
KW  - oncology
KW  - psycho-oncology
KW  - skills
Y1  - 2021
U6  - https://doi.org/10.1002/cam4.4396
SN  - 2045-7634
VL  - 10
SP  - 9012
EP  - 9021
PB  - Wiley
CY  - Hoboken, New Jersey, USA
ET  - 24
ER  - 
TY  - JOUR
A1  - Wojcik, Laurie Anne
A1  - Ceulemans, Ruben
A1  - Gaedke, Ursula
T1  - Functional diversity buffers the effects of a pulse perturbation on the dynamics of tritrophic food webs
JF  - Ecology and Evolution
N2  - Biodiversity decline causes a loss of functional diversity, which threatens ecosystems through a dangerous feedback loop: This loss may hamper ecosystems’ ability to buffer environmental changes, leading to further biodiversity losses. In this context, the increasing frequency of human-induced excessive loading of nutrients causes major problems in aquatic systems. Previous studies investigating how functional diversity influences the response of food webs to disturbances have mainly considered systems with at most two functionally diverse trophic levels. We investigated the effects of functional diversity on the robustness, that is, resistance, resilience, and elasticity, using a tritrophic—and thus more realistic—plankton food web model. We compared a non-adaptive food chain with no diversity within the individual trophic levels to a more diverse food web with three adaptive trophic levels. The species fitness differences were balanced through trade-offs between defense/growth rate for prey and selectivity/half-saturation constant for predators. We showed that the resistance, resilience, and elasticity of tritrophic food webs decreased with larger perturbation sizes and depended on the state of the system when the perturbation occurred. Importantly, we found that a more diverse food web was generally more resistant and resilient but its elasticity was context-dependent. Particularly, functional diversity reduced the probability of a regime shift toward a non-desirable alternative state. The basal-intermediate interaction consistently determined the robustness against a nutrient pulse despite the complex influence of the shape and type of the dynamical attractors. This relationship was strongly influenced by the diversity present and the third trophic level. Overall, using a food web model of realistic complexity, this study confirms the destructive potential of the positive feedback loop between biodiversity loss and robustness, by uncovering mechanisms leading to a decrease in resistance, resilience, and potentially elasticity as functional diversity declines.
KW  - functional diversity
KW  - nutrient spike
KW  - pulse perturbation
KW  - regime shift
KW  - robustness
KW  - tritrophic food web
Y1  - 2021
U6  - https://doi.org/10.1002/ece3.8214
SN  - 2045-7758
N1  - Wojcik and Ceulemans shared first authorship.
VL  - 11
IS  - 22
SP  - 15639
EP  - 15663
PB  - John Wiley & Sons, Inc.
CY  - Hoboken (New Jersey)
ER  - 
TY  - JOUR
A1  - Minnes, Mark
T1  - Más allá de la oscuridad
BT  - las "Soledades" de Góngora y el pirateo del lenguaje épico durante la primera globalización moderna
BT  - Góngora’s Soledades and the pirating of epic language during  the first modern phase of globalization
JF  - RILCE : revista de filología hispánica obalización moderna
N2  - En los últimos años, la crítica ha vuelto a enfatizar el vínculo de la escritura gongorina la épica y los subgéneros denominados “heroicos” (Mercedes Blanco, Jesús Ponce Cárdenas). Esta nueva perspectiva significa un cambio importante respecto a la recepción del poeta instaurada por la Generación del 27 y en particular por Dámaso Alonso. Limitándose a las Soledades de Góngora, el presente artículo explora las consecuencias de este nuevo paradigma, más allá de un Góngora puramente lírico. Metodológicamente, proponemos dejar atrás la dialéctica idealista o marxista de forma-contenido (la ideología de la forma de Fredric Jameson), por considerarla un enfoque anacrónico en el caso de Góngora. Sin embargo, encontramos un acercamiento filológico viable en el compromiso de la forma del temprano Barthes, que trata de esquivar la dialéctica de forma-contenido y volver a un gesto de escritura (écriture). La hipótesis del presente artículo sería, pues, que no se ha reflexionado suficientemente sobre el gesto de la escritura gongorina en las Soledades: una escritura que piratea el lenguaje épico.
N2  - In recent years, literary criticism has begun to  emphasize  the  linkage  between  Góngoras way of writing and epic or the so-called ‘heroic’ set of  subgenres  (Mercedes  Blanco,  Jesús  Ponce  Cárdenas). This new angle implies a considerable shift in  perspective  compared  to  the  reception  of  Góngora  by  the  Generación  del  27  and  especially  Dámaso  Alonso.  Limiting  itself  to  the  Soledades,  the present  article  explores  the  consequences  of  this new paradigm, beyond Góngora as a mere ‘lyricist’.
From  a  methodological  point  of  view,  we  will  not rely  on  the  idealist  or  Marxist  dialectic  of  form  and content (the ‘ideology of form’ of Fredric Jameson), which we consider an anachronism when referring to Góngora. Instead, the early Roland Barthes provides  an  alternative  by  suggesting  the  ‘commitment  to  form’  and  attempting  to  escape  the  dialectic  of  form  and  content  through  a  ‘gesture’  of écriture.  Thus,  the  present  article  postulates  that not  enough  critical  attention  has  been  paid  to  the ‘gesture’  of  Góngoras  writing   (écriture) in  the  Soledades: a writing that pirates the language of epic.
T2  - Beyond obscurity
KW  - Luis de Gongora
KW  - Literary Genres
KW  - Criticism and Style
KW  - Semantics of
KW  - Space
KW  - Globalization
KW  - Luis  de  Góngora
KW  - Géneros  literarios
KW  - Crítica y estilística
KW  - Semántica espacial
KW  - Globaización
Y1  - 2020
U6  - https://doi.org/10.15581/008.36.1.387-406
SN  - 0213-2370
SN  - 2174-0917
VL  - 36
IS  - 1
SP  - 387
EP  - 406
PB  - Ediciones Universidad de Navarra
CY  - Pamplona
ER  - 
TY  - JOUR
A1  - Endesfelder, Stefanie
A1  - Weichelt, Ulrike
A1  - Strauß, Evelyn
A1  - Schlör, Anja
A1  - Sifringer, Marco
A1  - Scheuer, Till
A1  - Bührer, Christoph
A1  - Schmitz, Thomas
T1  - Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury
JF  - International journal of molecular sciences
N2  - Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term “oxygen radical disease of prematurity”. Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28–32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NFκB), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.
KW  - anti-oxidative response
KW  - caffeine
KW  - hyperoxia
KW  - oxidative stress
KW  - preterm infants
KW  - developing brain
Y1  - 2017
U6  - https://doi.org/10.3390/ijms18010187
SN  - 1422-0067
SN  - 1661-6596
VL  - 18
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  - 
TY  - JOUR
A1  - Reeg, Jette
A1  - Strigl, Lea
A1  - Jeltsch, Florian
T1  - Agricultural buffer zone thresholds to safeguard functional bee diversity
BT  - Insights from a community modeling approach
JF  - Ecology and Evolution
N2  - Wild bee species are important pollinators in agricultural landscapes. However, population decline was reported over the last decades and is still ongoing. While agricultural intensification is a major driver of the rapid loss of pollinating species, transition zones between arable fields and forest or grassland patches, i.e., agricultural buffer zones, are frequently mentioned as suitable mitigation measures to support wild bee populations and other pollinator species. Despite the reported general positive effect, it remains unclear which amount of buffer zones is needed to ensure a sustainable and permanent impact for enhancing bee diversity and abundance. To address this question at a pollinator community level, we implemented a process-based, spatially explicit simulation model of functional bee diversity dynamics in an agricultural landscape. More specifically, we introduced a variable amount of agricultural buffer zones (ABZs) at the transition of arable to grassland, or arable to forest patches to analyze the impact on bee functional diversity and functional richness. We focused our study on solitary bees in a typical agricultural area in the Northeast of Germany. Our results showed positive effects with at least 25% of virtually implemented agricultural buffer zones. However, higher amounts of ABZs of at least 75% should be considered to ensure a sufficient increase in Shannon diversity and decrease in quasi-extinction risks. These high amounts of ABZs represent effective conservation measures to safeguard the stability of pollination services provided by solitary bee species. As the model structure can be easily adapted to other mobile species in agricultural landscapes, our community approach offers the chance to compare the effectiveness of conservation measures also for other pollinator communities in future.
KW  - agricultural landscape
KW  - buffer zones
KW  - community model
KW  - functional traits
KW  - solitary bees
KW  - spatially explicit
Y1  - 2022
U6  - https://doi.org/10.1002/ece3.8748
SN  - 2045-7758
VL  - 12
SP  - 1
EP  - 17
PB  - Wiley Online Library
CY  - Hoboken, New Jersey, USA
ET  - 3
ER  - 
TY  - JOUR
A1  - Kaunath, Vera
A1  - Eccard, Jana
T1  - Light Attraction in Carabid Beetles
BT  - Comparison Among Animals From the Inner City and a Dark Sky Reserve
JF  - Frontiers in Ecology and Evolution
N2  - Artificial light at night (ALAN) is altering the behaviour of nocturnal animals in a manifold of ways. Nocturnal invertebrates are particularly affected, due to their fatal attraction to ALAN. This selective pressure has the potential to reduce the strength of the flight-to-light response in insects, as shown recently in a moth species. Here we investigated light attraction of ground beetles (Coleoptera: Carabidae).We compared among animals (three genera) from a highly light polluted (HLP) grassland in the centre of Berlin and animals collected at a low-polluted area in a Dark Sky Reserve (DSR), captured using odour bait. In an arena setting tested at night time, HLP beetles (n = 75 across all genera) showed a reduced attraction towards ALAN. Tested during daytime, HLP beetles were less active in an open field test (measured as latency to start moving), compared to DSR (n = 143). However, we did not observe a reduced attraction towards ALAN within the species most common at both sides, Calathus fuscipes (HLP = 37, DSR = 118 individuals) indicating that not all species may be equally affected by ALAN. Reduced attraction to ALAN in urban beetles may either be a result of phenotypic selection in each generation removing HLP individuals that are attracted to light, or an indication for ongoing evolutionary differentiation among city and rural populations in their light response. Reduced attraction to light sources may directly enhance survival and reproductive success of urban individuals. However, decrease in mobility may negatively influence dispersal, reproduction and foraging success, highlighting the selective pressure that light pollution may have on fitness, by shaping and modifying the behaviour of insects.
KW  - light pollution
KW  - artificial light at night (ALAN)
KW  - Carabidae beetles
KW  - environmental change
KW  - Illuminance
KW  - solar powered light-emitting diode
Y1  - 2022
U6  - https://doi.org/10.3389/fevo.2022.751288
SN  - 2296-701X
N1  - VK and JE designed the experimental set up and research question. VK performed the animal trapping, experiments and hence, data collection, and organizing of the database. Both authors performed the statistical analyses and contributed to discussion, manuscript revision, read, and approved the submitted version.
VL  - 10
PB  - Frontiers Media
CY  - Lausanne, Schweiz
ER  - 
TY  - JOUR
A1  - Faber, Eike
T1  - Zweimal Kyros
BT  - die homonymen Perserfürsten und der Kampf um die Macht im Spiegel der Werke des Xenophon (Kyropädie, Anabasis)
JF  - Potestas : revista de estudios del mundo clásico e historia del arte
N2  - «Kyros» taucht als Fürstenname dreimal in der Überlieferung des Perserreiches auf. Der Historiker Xenophon von Athen (427–ca. 355 v. Chr.) hat in seinen Schriften über zwei Träger dieses Namens berichtet und sie durchaus unterschiedlich bewertet: Kyros II. («der Große»), Mehrer des Reiches, sowie ein Jahrhundert später Kyros, Sohn des Dareios und jüngerer Bruder des Perserkönigs Artaxerxes II. Der ältere Kyros ist namengebender Protagonist eines Fürstenspiegels (der Kyropädie), wird also grundsätzlich positiv und als ein Vorbild für andere dargestellt. Am erfolglosen Kampf des jüngeren Kyros um die Krone des Perserreichs hatte Xenophon als Offizier griechischer Söldner selbst teilgenommen. Aus dem Vergleich von Darstellung und Bewertung der beiden Fürsten lassen sich die Ansprüche Xenophons an einen idealen Herrscher ableiten, was hier unternommen werden soll. Zugleich ermöglichen diese Ergebnisse, Xenophon als Historiker und politischen Denker in der zeitgenössischen Debatte um die beste Staatsform einzubetten.
N2  - «Cyrus» as the name of a prince occurs thrice in the annals of the Persian Empire. e historian Xenophon of Athens (427–about 355 BC) wrote about two bearers of that name: Cyrus II. («the Great») and, roughly a century later, the younger Cyrus, son of Darius II. and younger brother of Artaxerxes II., the Persian king. e older Cyrus gives his name to a mirror of princes (the Cyrupaedia) and is portrayed positively and as an inspiration to others. Xenophon himself had been an officer in the failed attempt of the younger Cyrus to win the Persian throne by military force. By comparing the way Xenophon depicts and judges both princes, we can deduct what our historian expected of an ideal ruler. ese expectations place Xenophon in the wide contemporary spectrum of opinions on the best constitution (monarchy, oligarchy, democracy).
KW  - Herodot
KW  - Xenophon von Athen
KW  - Kyros II
KW  - griechische Geschichtsschreibung
KW  - Altorientalische Monarchie
KW  - Herodotus
KW  - Xenophon of Athens
KW  - Cyrus II
KW  - Greek Historiography
KW  - Oriental/Persian Monarchy
Y1  - 2016
UR  - https://www.e-revistes.uji.es/index.php/potestas/article/view/2308
U6  - https://doi.org/10.6035/potestas.2015.8.2
SN  - 1888-9867
SN  - 2340-499X
IS  - 8
SP  - 37
EP  - 56
PB  - Universitat Jaume I
CY  - Castellón
ER  - 
TY  - JOUR
A1  - Faber, Eike
T1  - Macht der Rhetorik - Rhetorik der Macht
BT  - zum athenischen Epitaphios
JF  - Potestas : revista de estudios del mundo clásico e historia del arte
N2  - ie athenische Totenrede (epitaphios logos) spielte eine  Schlüsselrolle  bei  der  Konstruktion  des idealisierten  Selbstbildes  des  demokratischen  Athen (5./4. Jh.v.Chr.).  Dieser  Aufsatz  zeigt  auf,  dass  die  beiden  bekanntesten  Beispiele  für  das  rhetorische  Genre,  die  Rede  des  Perikes  auf  die  Gefallenen  bei  Thukydides  und  die  Rede  des  Sokrates  im  platonischen  Dialog  Menexenos,  tatsächlich  scharfe  Kritik  an der Instituton der Totenrede und an der demokratischen Polis an sich üben,  obwohl  beide  Texte  für  sich  betrachtet  gemeinhin  als  affirmativ verstanden werden.
N2  - The epitaphios logos played an integral part in the construction of an idealised self-image of democratic Athens (5th / 4th century BC). This paper shows that two famous examples of this rhetorical genre, the orations of Pericles (in the History of the Peloponnesian War by Thucydides) and Socrates (in the Platonic dialogue Menexenos), generally regarded as affirmative, are very critical of the institution and the democratic polis as such.
KW  - Athen
KW  - politische Rhetorik
KW  - Platon
KW  - Thukydides
KW  - Athens
KW  - political rhetoric
Y1  - 2009
UR  - https://www.e-revistes.uji.es/index.php/potestas/article/view/112
SN  - 1888-9867
SN  - 2340-499X
VL  - 2
IS  - 2
SP  - 117
EP  - 132
PB  - Universitat Jaume
CY  - Castellón
ER  - 
TY  - JOUR
A1  - Kaiser, Michaela
A1  - Brenne, Andreas
T1  - Ästhetik - Normativität - Diversität
BT  - zum kunstpädagogischen Umgang mit Diversität
JF  - Individuelle Förderung - Heterogenität und Handlungsperspektiven in der Schule
Y1  - 2022
UR  - https://elibrary.utb.de/doi/book/10.36198/9783838559193
SN  - 978-3-8385-5919-3
SN  - 978-3-8252-5919-8
U6  - https://doi.org/10.36198/9783838559193
SP  - 249
EP  - 259
PB  - Waxmann
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Liebe, Thomas
A1  - Dordevic, Milos
A1  - Kaufmann, Jörn
A1  - Avetisyan, Araks
A1  - Skalej, Martin
A1  - Müller, Notger Germar
T1  - Investigation of the functional pathogenesis of mild cognitive impairment by localisation-based locus coeruleus resting-state fMRI
JF  - Human Brain Mapping
N2  - Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.
KW  - attention
KW  - locus coeruleus
KW  - mild cognitive impairment
KW  - resting-state fMRI
Y1  - 2022
U6  - https://doi.org/10.1002/hbm.26039
SN  - 1097-0193
VL  - 43
SP  - 5630
EP  - 5642
PB  - Wiley
CY  - New York, NY, USA
ET  - 18
ER  - 
TY  - JOUR
A1  - Hauffe, Robert
A1  - Rath, Michaela
A1  - Agyapong, Wilson
A1  - Jonas, Wenke
A1  - Vogel, Heike
A1  - Schulz, Tim Julius
A1  - Schwarz, Maria
A1  - Kipp, Anna Patricia
A1  - Blüher, Matthias
A1  - Kleinridders, André
T1  - Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling
JF  - Antioxidants
N2  - The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.
KW  - selenite
KW  - insulin
KW  - adipose tissue
KW  - obesity
KW  - insulin resistance
Y1  - 2022
U6  - https://doi.org/10.3390/antiox11050862
SN  - 2076-3921
VL  - 11
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel, Schweiz
ET  - 5
ER  - 
TY  - JOUR
A1  - Otto, Nils
A1  - Marelja, Zvonimir
A1  - Schoofs, Andreas
A1  - Kranenburg, Holger
A1  - Bittern, Jonas
A1  - Yildirim, Kerem
A1  - Berh, Dimitri
A1  - Bethke, Maria
A1  - Thomas, Silke
A1  - Rode, Sandra
A1  - Risse, Benjamin
A1  - Jiang, Xiaoyi
A1  - Pankratz, Michael
A1  - Leimkühler, Silke
A1  - Klämbt, Christian
T1  - The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
JF  - Nature Communications
N2  - Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet. To decipher a possible role of ensheathing glia in neuronal information processing, we screened for glial genes required in the Drosophila central nervous system for normal locomotor behavior. Shopper encodes a mitochondrial sulfite oxidase that is specifically required in ensheathing glia to regulate head bending and peristalsis. shopper mutants show elevated sulfite levels affecting the glutamate homeostasis which then act on neuronal network function. Interestingly, human patients lacking the Shopper homolog SUOX develop neurological symptoms, including seizures. Given an enhanced expression of SUOX by oligodendrocytes, our findings might indicate that in both invertebrates and vertebrates more than one glial cell type may be involved in modulating neuronal activity.
Y1  - 2018
U6  - https://doi.org/10.1038/s41467-018-05645-z
SN  - 2041-1723
VL  - 9
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Krstic, Jelena
A1  - Reinisch, Isabel
A1  - Schupp, Michael
A1  - Schulz, Tim Julius
A1  - Prokesch, Andreas
T1  - p53 functions in adipose tissue metabolism and homeostasis
JF  - International journal of molecular sciences
N2  - As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the best-described molecules in medical research. As cancer is in most cases an age-related disease, it seems paradoxical that p53 is so strongly conserved from early multicellular organisms to humans. A function not directly related to tumor suppression, such as the regulation of metabolism in nontransformed cells, could explain this selective pressure. While this role of p53 in cellular metabolism is gradually emerging, it is imperative to dissect the tissue-and cell-specific actions of p53 and its downstream signaling pathways. In this review, we focus on studies reporting p53's impact on adipocyte development, function, and maintenance, as well as the causes and consequences of altered p53 levels in white and brown adipose tissue (AT) with respect to systemic energy homeostasis. While whole body p53 knockout mice gain less weight and fat mass under a high-fat diet owing to increased energy expenditure, modifying p53 expression specifically in adipocytes yields more refined insights: (1) p53 is a negative regulator of in vitro adipogenesis; (2) p53 levels in white AT are increased in diet-induced and genetic obesity mouse models and in obese humans; (3) functionally, elevated p53 in white AT increases senescence and chronic inflammation, aggravating systemic insulin resistance; (4) p53 is not required for normal development of brown AT; and (5) when p53 is activated in brown AT in mice fed a high-fat diet, it increases brown AT temperature and brown AT marker gene expression, thereby contributing to reduced fat mass accumulation. In addition, p53 is increasingly being recognized as crucial player in nutrient sensing pathways. Hence, despite existence of contradictory findings and a varying density of evidence, several functions of p53 in adipocytes and ATs have been emerging, positioning p53 as an essential regulatory hub in ATs. Future studies need to make use of more sophisticated in vivo model systems and should identify an AT-specific set of p53 target genes and downstream pathways upon different (nutrient) challenges to identify novel therapeutic targets to curb metabolic diseases
KW  - p53
KW  - adipose tissue
KW  - metabolic syndrome
KW  - obesity
KW  - adipogenesis
KW  - insulin resistance
Y1  - 2018
U6  - https://doi.org/10.3390/ijms19092622
SN  - 1422-0067
VL  - 19
IS  - 9
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schulze, Sven
A1  - Wehrhold, Michel
A1  - Hille, Carsten
T1  - Femtosecond-Pulsed laser written and etched fiber bragg gratings for fiber-optical biosensing
JF  - Sensors
N2  - We present the development of a label-free, highly sensitive fiber-optical biosensor for online detection and quantification of biomolecules. Here, the advantages of etched fiber Bragg gratings (eFBG) were used, since they induce a narrowband Bragg wavelength peak in the reflection operation mode. The gratings were fabricated point-by-point via a nonlinear absorption process of a highly focused femtosecond-pulsed laser, without the need of prior coating removal or specific fiber doping. The sensitivity of the Bragg wavelength peak to the surrounding refractive index (SRI), as needed for biochemical sensing, was realized by fiber cladding removal using hydrofluoric acid etching. For evaluation of biosensing capabilities, eFBG fibers were biofunctionalized with a single-stranded DNA aptamer specific for binding the C-reactive protein (CRP). Thus, the CRP-sensitive eFBG fiber-optical biosensor showed a very low limit of detection of 0.82 pg/L, with a dynamic range of CRP detection from approximately 0.8 pg/L to 1.2 mu g/L. The biosensor showed a high specificity to CRP even in the presence of interfering substances. These results suggest that the proposed biosensor is capable for quantification of CRP from trace amounts of clinical samples. In addition, the adaption of this eFBG fiber-optical biosensor for detection of other relevant analytes can be easily realized.
KW  - fiber Bragg gratings
KW  - ultra-fast laser inscription
KW  - fiber etching
KW  - nanostructure fabrication
KW  - fiber-optical sensors
KW  - aptamers
KW  - C-reactive protein
KW  - biomarker
Y1  - 2018
U6  - https://doi.org/10.3390/s18092844
SN  - 1424-8220
VL  - 18
IS  - 9
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Biterova, Ekaterina
A1  - Esmaeeli Moghaddam Tabalvandani, Mariam
A1  - Alanen, Heli I.
A1  - Saaranen, Mirva
A1  - Ruddock, Lloyd W.
T1  - Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease
JF  - Scientific reports
N2  - Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery disease.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-25237-7
SN  - 2045-2322
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Xiong, Chao
A1  - Stolle, Claudia
A1  - Park, Jaeheung
T1  - Climatology of GPS signal loss observed by Swarm satellites
JF  - Annales geophysicae
N2  - By using 3-year global positioning system (GPS) measurements from December 2013 to November 2016, we provide in this study a detailed survey on the climatology of the GPS signal loss of Swarm onboard receivers. Our results show that the GPS signal losses prefer to occur at both low latitudes between +/- 5 and +/- 20 degrees magnetic latitude (MLAT) and high latitudes above 60 degrees MLAT in both hemispheres. These events at all latitudes are observed mainly during equinoxes and December solstice months, while totally absent during June solstice months. At low latitudes the GPS signal losses are caused by the equatorial plasma irregularities shortly after sunset, and at high latitude they are also highly related to the large density gradients associated with ionospheric irregularities. Additionally, the high-latitude events are more often observed in the Southern Hemisphere, occurring mainly at the cusp region and along nightside auroral latitudes. The signal losses mainly happen for those GPS rays with elevation angles less than 20 degrees, and more commonly occur when the line of sight between GPS and Swarm satellites is aligned with the shell structure of plasma irregularities. Our results also confirm that the capability of the Swarm receiver has been improved after the bandwidth of the phase-locked loop (PLL) widened, but the updates cannot radically avoid the interruption in tracking GPS satellites caused by the ionospheric plasma irregularities. Additionally, after the PLL bandwidth increased larger than 0.5 Hz, some unexpected signal losses are observed even at middle latitudes, which are not related to the ionospheric plasma irregularities. Our results suggest that rather than 1.0 Hz, a PLL bandwidth of 0.5 Hz is a more suitable value for the Swarm receiver.
KW  - Ionosphere
KW  - equatorial ionosphere
KW  - ionospheric irregularities
KW  - radio science
KW  - radio wave propagation
Y1  - 2018
U6  - https://doi.org/10.5194/angeo-36-679-2018
SN  - 0992-7689
SN  - 1432-0576
VL  - 36
IS  - 2
SP  - 679
EP  - 693
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Kucian, Karin
A1  - Zuber, Isabelle
A1  - Kohn, Juliane
A1  - Poltz, Nadine
A1  - Wyschkon, Anne
A1  - Esser, Günter
A1  - von Aster, Michael G.
T1  - Relation Between Mathematical Performance, Math Anxiety, and Affective Priming in Children With and Without Developmental Dyscalculia
JF  - Frontiers in psychology
N2  - Many children show negative emotions related to mathematics and some even develop mathematics anxiety. The present study focused on the relation between negative emotions and arithmetical performance in children with and without developmental dyscalculia (DD) using an affective priming task. Previous findings suggested that arithmetic performance is influenced if an affective prime precedes the presentation of an arithmetic problem. In children with DD specifically, responses to arithmetic operations are supposed to be facilitated by both negative and mathematics-related primes (= negative math priming effect). We investigated mathematical performance, math anxiety, and the domain-general abilities of 172 primary school children (76 with DD and 96 controls). All participants also underwent an affective priming task which consisted of the decision whether a simple arithmetic operation (addition or subtraction) that was preceded by a prime (positive/negative/neutral or mathematics-related) was true or false. Our findings did not reveal a negative math priming effect in children with DD. Furthermore, when considering accuracy levels, gender, or math anxiety, the negative math priming effect could not be replicated. However, children with DD showed more math anxiety when explicitly assessed by a specific math anxiety interview and showed lower mathematical performance compared to controls. Moreover, math anxiety was equally present in boys and girls, even in the earliest stages of schooling, and interfered negatively with performance. In conclusion, mathematics is often associated with negative emotions that can be manifested in specific math anxiety, particularly in children with DD. Importantly, present findings suggest that in the assessed age group, it is more reliable to judge math anxiety and investigate its effects on mathematical performance explicitly by adequate questionnaires than by an affective math priming task.
KW  - developmental dyscalculia
KW  - mathematics
KW  - affective priming
KW  - calculation
KW  - arithmetic
KW  - anxiety
KW  - gender
KW  - children
Y1  - 2018
U6  - https://doi.org/10.3389/fpsyg.2018.00263
SN  - 1664-1078
VL  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Coesfeld, Jacqueline
A1  - Kuester, Theres
A1  - Kuechly, Helga U.
A1  - Kyba, Christopher C. M.
T1  - Reducing variability and removing natural light from nighttime satellite imagery: A case study using the VIIRS DNB
JF  - Sensors
N2  - Temporal variation of natural light sources such as airglow limits the ability of night light sensors to detect changes in small sources of artificial light (such as villages). This study presents a method for correcting for this effect globally, using the satellite radiance detected from regions without artificial light emissions. We developed a routine to define an approximate grid of locations worldwide that do not have regular light emission. We apply this method with a 5 degree equally spaced global grid (total of 2016 individual locations), using data from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day-Night Band (DNB). This code could easily be adapted for other future global sensors. The correction reduces the standard deviation of data in the Earth Observation Group monthly DNB composites by almost a factor of two. The code and datasets presented here are available under an open license by GFZ Data Services, and are implemented in the Radiance Light Trends web application.
KW  - airglow
KW  - artificial light
KW  - calibration
KW  - VIIRS DNB
KW  - nightlights
KW  - remote sensing
Y1  - 2020
VL  - 20
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Dunsing, Valentin
A1  - Luckner, Madlen
A1  - Zuehlke, Boris
A1  - Petazzi, Roberto Arturo
A1  - Herrmann, Andreas
A1  - Chiantia, Salvatore
T1  - Optimal fluorescent protein tags for quantifying protein oligomerization in living cells
JF  - Scientific reports
N2  - Fluorescence fluctuation spectroscopy has become a popular toolbox for non-disruptive analysis of molecular interactions in living cells. The quantification of protein oligomerization in the native cellular environment is highly relevant for a detailed understanding of complex biological processes. An important parameter in this context is the molecular brightness, which serves as a direct measure of oligomerization and can be easily extracted from temporal or spatial fluorescence fluctuations. However, fluorescent proteins (FPs) typically used in such studies suffer from complex photophysical transitions and limited maturation, inducing non-fluorescent states. Here, we show how these processes strongly affect molecular brightness measurements. We perform a systematic characterization of non-fluorescent states for commonly used FPs and provide a simple guideline for accurate, unbiased oligomerization measurements in living cells. Further, we focus on novel red FPs and demonstrate that mCherry2, an mCherry variant, possesses superior properties with regards to precise quantification of oligomerization.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-28858-0
SN  - 2045-2322
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Zeeden, Christian
A1  - Obreht, Igor
A1  - Veres, Daniel
A1  - Kaboth-Bahr, Stefanie
A1  - Hošek, Jan
A1  - Marković, Slobodan B.
A1  - Bösken, Janina
A1  - Lehmkuhl, Frank
A1  - Rolf, Christian
A1  - Hambach, Ulrich
T1  - Smoothed millennial-scale palaeoclimatic reference data as unconventional comparison targets: Application to European loess records
JF  - Scientific Reports
N2  - Millennial-scale palaeoclimate variability has been documented in various terrestrial and marine palaeoclimate proxy records throughout the Northern Hemisphere for the last glacial cycle. Its clear expression and rapid shifts between different states of climate (Greenland Interstadials and Stadials) represents a correlation tool beyond the resolution of e.g. luminescence dating, especially relevant for terrestrial deposits. Usually, comparison of terrestrial proxy datasets and the Greenland ice cores indicates a complex expression of millennial-scale climate variability as recorded in terrestrial geoarchives including loess. Loess is the most widespread terrestrial geoarchive of the Quaternary and especially widespread over Eurasia. However, loess often records a smoothed representation of millennial-scale variability without all fidelity when compared to the Greenland data, this being a relevant limiting feature in integrating loess with other palaeoclimate records. To better understand the loess proxy-response to millennial-scale climate variability, we simulate a proxy signal smoothing by natural processes through application of low-pass filters of delta O-18 data from Greenland, a high-resolution palaeoclimate reference record, alongside speleothem isotope records from the Black Sea-Mediterranean region. We show that low-pass filters represent rather simple models for better constraining the expression of millennial-scale climate variability in low sedimentation environments, and in sediments where proxy-response signals are most likely affected by natural smoothing (by e.g. bioturbation). Interestingly, smoothed datasets from Greenland and the Black Sea-Mediterranean region are most similar in the last similar to 15 ka and between similar to 50-30 ka. Between similar to 30-15 ka, roughly corresponding to the Last Glacial Maximum and the deglaciation, the records show dissimilarities, challenging the construction of robust correlative time-scales in this age range. From our analysis it becomes apparent that patterns of palaeoclimate signals in loess-palaeosol sequences often might be better explained by smoothed Greenland reference data than the original high-resolution Greenland dataset, or other reference data. This opens the possibility to better assess the temporal resolution and palaeoclimate potential of loess-palaeosol sequences in recording supra-regional climate patterns, as well as to securely integrate loess with other chronologically better-resolved palaeoclimate records.
KW  - last glacial period
KW  - Western Interior Basin
KW  - high-resolution record
KW  - Greenland ice cores
KW  - paleosol sequence
KW  - time-scale
KW  - Chinese loess
KW  - astronomical calibration
KW  - chronology (AICC2012)
KW  - Antarctic ice
Y1  - 2020
VL  - 10
IS  - 1
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Richly, Keven
A1  - Brauer, Janos
A1  - Schlosser, Rainer
T1  - Predicting location probabilities of drivers to improved dispatch decisions of transportation network companies based on trajectory data
JF  - Proceedings of the 9th International Conference on Operations Research and Enterprise Systems - ICORES
N2  - The demand for peer-to-peer ridesharing services increased over the last years rapidly. To cost-efficiently dispatch orders and communicate accurate pick-up times is challenging as the current location of each available driver is not exactly known since observed locations can be outdated for several seconds. The developed trajectory visualization tool enables transportation network companies to analyze dispatch processes and determine the causes of unexpected delays. As dispatching algorithms are based on the accuracy of arrival time predictions, we account for factors like noise, sample rate, technical and economic limitations as well as the duration of the entire process as they have an impact on the accuracy of spatio-temporal data. To improve dispatching strategies, we propose a prediction approach that provides a probability distribution for a driver’s future locations based on patterns observed in past trajectories. We demonstrate the capabilities of our prediction results to ( i) avoid critical delays, (ii) to estimate waiting times with higher confidence, and (iii) to enable risk considerations in dispatching strategies.
KW  - trajectory data
KW  - location prediction algorithm
KW  - Peer-to-Peer ridesharing
KW  - transport network companies
KW  - risk-aware dispatching
Y1  - 2020
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Söchting, Maximilian
A1  - Trapp, Matthias
T1  - Controlling image-stylization techniques using eye tracking
JF  - Science and Technology Publications
N2  - With the spread of smart phones capable of taking high-resolution photos and the development of high-speed mobile data infrastructure, digital visual media is becoming one of the most important forms of modern communication. With this development, however, also comes a devaluation of images as a media form with the focus becoming the frequency at which visual content is generated instead of the quality of the content. In this work, an interactive system using image-abstraction techniques and an eye tracking sensor is presented, which allows users to experience diverting and dynamic artworks that react to their eye movement. The underlying modular architecture enables a variety of different interaction techniques that share common design principles, making the interface as intuitive as possible. The resulting experience allows users to experience a game-like interaction in which they aim for a reward, the artwork, while being held under constraints, e.g., not blinking. The co nscious eye movements that are required by some interaction techniques hint an interesting, possible future extension for this work into the field of relaxation exercises and concentration training.
KW  - Eye-tracking
KW  - Image Abstraction
KW  - Image Processing
KW  - Artistic Image Stylization
KW  - Interactive Media
Y1  - 2020
SN  - 2184-4321
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Caliendo, Marco
A1  - Goethner, Maximilian
A1  - Weißenberger, Martin
T1  - Entrepreneurial persistence beyond survival: Measurement and determinants
JF  - Journal of Small Business Management
N2  - Entrepreneurial persistence is demonstrated by an entrepreneur’s continued positive maintenance of entrepreneurial motivation and constantly renewed active engagement in a new business venture despite counterforces or enticing alternatives. It thus is a crucial factor for entrepreneurs when pursuing and exploiting their business opportunities and in realizing potential economic gains and benefits. Using rich data on a representative sample of German business founders, we investigated the determinants of entrepreneurial persistence. Next to observed survival, we also constructed a hybrid persistence measure capturing the motivational dimension of persistence. We analyzed the influence of individual-level (human capital and personality) and business-related characteristics on both measures as well as their relative importance. We found that the two indicators emphasize different aspects of persistence. For the survival indicator, the predictive power was concentrated in business characteristics and human capital, while for hybrid persistence the dominant factors were business characteristics and personality. Finally, we showed that results were heterogeneous across subgroups. In particular, formerly unemployed founders did not differ in survival chances, but they were more likely to lack a high psychological commitment to their business ventures.
KW  - entrepreneurship
KW  - startups
KW  - persistence
KW  - survival
Y1  - 2019
VL  - 58
IS  - 3
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Naliboff, John B.
A1  - Glerum, Anne
A1  - Brune, Sascha
A1  - Péron-Pinvidic, G.
A1  - Wrona, Thilo
T1  - Development of 3-D rift heterogeneity through fault network evolution
JF  - Geophysical Research Letters
N2  - Observations of rift and rifted margin architecture suggest that significant spatial and temporal structural heterogeneity develops during the multiphase evolution of continental rifting. Inheritance is often invoked to explain this heterogeneity, such as preexisting anisotropies in rock composition, rheology, and deformation. Here, we use high-resolution 3-D thermal-mechanical numerical models of continental extension to demonstrate that rift-parallel heterogeneity may develop solely through fault network evolution during the transition from distributed to localized deformation. In our models, the initial phase of distributed normal faulting is seeded through randomized initial strength perturbations in an otherwise laterally homogeneous lithosphere extending at a constant rate. Continued extension localizes deformation onto lithosphere-scale faults, which are laterally offset by tens of km and discontinuous along-strike. These results demonstrate that rift- and margin-parallel heterogeneity of large-scale fault patterns may in-part be a natural byproduct of fault network coalescence.
KW  - magma-poor
KW  - continental lithosphere
KW  - extension
KW  - insights
KW  - margins
KW  - architecture
KW  - systems
KW  - models
KW  - sea
KW  - reactivation
Y1  - 2019
VL  - 47
IS  - 13
PB  - John Wiley & Sons, Inc.
CY  - New Jersey
ER  - 
TY  - JOUR
A1  - Zimmermann, Malte
A1  - De Veaugh-Geiss, Joseph P.
A1  - Tönnis, Swantje
A1  - Onea, Edgar
T1  - (Non-)exhaustivity in focus partitioning across languages
JF  - Approaches to Hungarian
N2  - We present novel experimental evidence on the availability and the status of exhaustivity inferences with focus partitioning in German, English, and Hungarian. Results suggest that German and English focus-background clefts and Hungarian focus share important properties, (É. Kiss 1998, 1999; Szabolcsi 1994; Percus 1997; Onea & Beaver 2009). Those constructions are anaphoric devices triggering an existence presupposition. EXH-inferences are not obligatory in such constructions in English, German, or Hungarian, against some previous literature (Percus 1997; Büring & Križ 2013; É. Kiss 1998), but in line with pragmatic analyses of EXH-inferences in clefts (Horn 1981, 2016; Pollard & Yasavul 2016). The cross-linguistic differences in the distribution of EXH-inferences are attributed to properties of the Hungarian number marking system.
KW  - clefts
KW  - definite pseudoclefts
KW  - Hungarian focus
KW  - exhaustivity
KW  - experimental evidence
KW  - semantics-pragmatics interface
Y1  - 2020
VL  - 16
PB  - John Benjamins
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Zwickel, Theresa
A1  - Kahl, Sandra M.
A1  - Rychlik, Michael
A1  - Müller, Marina E. H.
T1  - Chemotaxonomy of Mycotoxigenic Small-Spored Alternaria Fungi
BT  - Do Multitoxin Mixtures Act as an Indicator for Species Differentiation?
JF  - Frontiers in microbiology
N2  - Necrotrophic as well as saprophytic small-spored Altemaria (A.) species are annually responsible for major losses of agricultural products, such as cereal crops, associated with the contamination of food and feedstuff with potential health-endangering Altemaria toxins. Knowledge of the metabolic capabilities of different species-groups to form mycotoxins is of importance for a reliable risk assessment. 93 Altemaria strains belonging to the four species groups Alternaria tenuissima, A. arborescens, A. altemata, and A. infectoria were isolated from winter wheat kernels harvested from fields in Germany and Russia and incubated under equal conditions. Chemical analysis by means of an HPLC-MS/MS multi-Alternaria-toxin-method showed that 95% of all strains were able to form at least one of the targeted 17 non-host specific Altemaria toxins. Simultaneous production of up to 15 (modified) Altemaria toxins by members of the A. tenuissima, A. arborescens, A. altemata species-groups and up to seven toxins by A. infectoria strains was demonstrated. Overall tenuazonic acid was the most extensively formed mycotoxin followed by alternariol and alternariol mono methylether, whereas altertoxin I was the most frequently detected toxin. Sulfoconjugated modifications of alternariol, alternariol mono methylether, altenuisol and altenuene were frequently determined. Unknown perylene quinone derivatives were additionally detected. Strains of the species-group A. infectoria could be segregated from strains of the other three species-groups due to significantly lower toxin levels and the specific production of infectopyrone. Apart from infectopyrone, alterperylenol was also frequently produced by 95% of the A. infectoria strains. Neither by the concentration nor by the composition of the targeted Altemaria toxins a differentiation between the species-groups A. altemata, A. tenuissima and A. arborescens was possible.
KW  - small-spored Alternaria fungi
KW  - Alternaria species-groups
KW  - Alternaria mycotoxins
KW  - chemotaxonomy
KW  - secondary metabolite profiling
KW  - LC-MS/MS
KW  - wheat
KW  - perylene quinone derivatives
Y1  - 2018
U6  - https://doi.org/10.3389/fmicb.2018.01368
SN  - 1664-302X
VL  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Heger, Tina
A1  - Nikles, Gabriele
A1  - Jacobs, Brooke S.
T1  - Differentiation in native as well as introduced ranges
BT  - germination reflects mean and variance in cover of surrounding vegetation
JF  - AoB PLANTS
N2  - Germination, a crucial phase in the life cycle of a plant, can be significantly influenced by competition and facilitation. The aim of this study was to test whether differences in cover of surrounding vegetation can lead to population differentiation in germination behaviour of an annual grassland species, and if so, whether such a differentiation can be found in the native as well as in the introduced range. We used maternal progeny of Erodium cicutarium previously propagated under uniform conditions that had been collected in multiple populations in the native and two introduced ranges, in populations representing extremes in terms of mean and variability of the cover of surrounding vegetation. In the first experiment, we tested the effect of germination temperature and mean cover at the source site on germination, and found interlinked effects of these factors. In seeds from one of the introduced ranges (California), we found indication for a 2-fold dormancy, hindering germination at high temperatures even if physical dormancy was broken and water was available. This behaviour was less strong in high cover populations, indicating cross-generational facilitating effects of dense vegetation. In the second experiment, we tested whether spatial variation in cover of surrounding vegetation has an effect on the proportion of dormant seeds. Contrary to our expectations, we found that across source regions, high variance in cover was associated with higher proportions of seeds germinating directly after storage. In all three regions, germination seemed to match the local environment in terms of climate and vegetation cover. We suggest that this is due to a combined effect of introduction of preadapted genotypes and local evolutionary processes.
KW  - Bet-hedging
KW  - competition
KW  - eco-evolutionary experience
KW  - facilitation
KW  - genetic adaptation
KW  - physical and physiological dormancy
KW  - preadaptation
Y1  - 2018
U6  - https://doi.org/10.1093/aobpla/ply009
SN  - 2041-2851
VL  - 10
IS  - 1
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Hesse, Julia
A1  - Klier, Dennis Tobias
A1  - Sgarzi, Massimo
A1  - Nsubuga, Anne
A1  - Bauer, Christoph
A1  - Grenzer, Joerg
A1  - Hübner, Rene
A1  - Wislicenus, Marcus
A1  - Joshi, Tanmaya
A1  - Kumke, Michael Uwe
A1  - Stephan, Holger
T1  - Rapid Synthesis of Sub-10nm Hexagonal NaYF4-Based Upconverting Nanoparticles using Therminol((R))66
JF  - ChemistryOpen : including thesis treasury
N2  - We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.
KW  - core-shell materials
KW  - lanthanides
KW  - nanostructures
KW  - photoluminescence
KW  - upconversion
Y1  - 2018
U6  - https://doi.org/10.1002/open.201700186
SN  - 2191-1363
VL  - 7
IS  - 2
SP  - 159
EP  - 168
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Käch, Heidi
A1  - Mathe-Hubert, Hugo
A1  - Dennis, Alice B.
A1  - Vorburger, Christoph
T1  - Rapid evolution of symbiont-mediated resistance compromises biological control of aphids by parasitoids
JF  - Evolutionary applications
N2  - There is growing interest in biological control as a sustainable and environmentally friendly way to control pest insects. Aphids are among the most detrimental agricultural pests worldwide, and parasitoid wasps are frequently employed for their control. The use of asexual parasitoids may improve the effectiveness of biological control because only females kill hosts and because asexual populations have a higher growth rate than sexuals. However, asexuals may have a reduced capacity to track evolutionary change in their host populations. We used a factorial experiment to compare the ability of sexual and asexual populations of the parasitoid Lysiphlebus fabarum to control caged populations of black bean aphids (Aphis fabae) of high and low clonal diversity. The aphids came from a natural population, and one-third of the aphid clones harbored Hamiltonella defensa, a heritable bacterial endosymbiont that increases resistance to parasitoids. We followed aphid and parasitoid population dynamics for 3months but found no evidence that the reproductive mode of parasitoids affected their effectiveness as biocontrol agents, independent of host clonal diversity. Parasitoids failed to control aphids in most cases, because their introduction resulted in strong selection for clones protected by H.defensa. The increasingly resistant aphid populations escaped control by parasitoids, and we even observed parasitoid extinctions in many cages. The rapid evolution of symbiont-conferred resistance in turn imposed selection on parasitoids. In cages where asexual parasitoids persisted until the end of the experiment, they became dominated by a single genotype able to overcome the protection provided by H.defensa. Thus, there was evidence for parasitoid counteradaptation, but it was generally too slow for parasitoids to regain control over aphid populations. It appears that when pest aphids possess defensive symbionts, the presence of parasitoid genotypes able to overcome symbiont-conferred resistance is more important for biocontrol success than their reproductive mode.
KW  - aphids
KW  - Aphis fabae
KW  - biological control
KW  - defensive symbiosis
KW  - Hamiltonella defensa
KW  - Lysiphlebus fabarum
KW  - parasitoid
KW  - resistance
Y1  - 2018
U6  - https://doi.org/10.1111/eva.12532
SN  - 1752-4571
VL  - 11
IS  - 2
SP  - 220
EP  - 230
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Shi, Jun
A1  - Joshi, Jasmin Radha
A1  - Tielboerger, Katja
A1  - Verhoeven, Koen J. F.
A1  - Macel, Mirka
T1  - Costs and benefits of admixture between foreign genotypes and local populations in the field
JF  - Ecology and evolution
N2  - Admixture is the hybridization between populations within one species. It can increase plant fitness and population viability by alleviating inbreeding depression and increasing genetic diversity. However, populations are often adapted to their local environments and admixture with distant populations could break down local adaptation by diluting the locally adapted genomes. Thus, admixed genotypes might be selected against and be outcompeted by locally adapted genotypes in the local environments. To investigate the costs and benefits of admixture, we compared the performance of admixed and within-population F1 and F2 generations of the European plant Lythrum salicaria in a reciprocal transplant experiment at three European field sites over a 2-year period. Despite strong differences between site and plant populations for most of the measured traits, including herbivory, we found limited evidence for local adaptation. The effects of admixture depended on experimental site and plant population, and were positive for some traits. Plant growth and fruit production of some populations increased in admixed offspring and this was strongest with larger parental distances. These effects were only detected in two of our three sites. Our results show that, in the absence of local adaptation, admixture may boost plant performance, and that this is particularly apparent in stressful environments. We suggest that admixture between foreign and local genotypes can potentially be considered in nature conservation to restore populations and/or increase population viability, especially in small inbred or maladapted populations.
KW  - heterosis
KW  - inbreeding depression
KW  - local adaptation
KW  - Lythrum salicaria
KW  - outbreeding depression
Y1  - 2018
U6  - https://doi.org/10.1002/ece3.3946
SN  - 2045-7758
VL  - 8
IS  - 7
SP  - 3675
EP  - 3684
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Frank, Mario
A1  - Kreitz, Christoph
T1  - A theorem prover for scientific and educational purposes
T2  - Electronic proceedings in theoretical computer science
N2  - We present a prototype of an integrated reasoning environment for educational purposes. The presented tool is a fragment of a proof assistant and automated theorem prover. We describe the existing and planned functionality of the theorem prover and especially the functionality of the educational fragment. This currently supports working with terms of the untyped lambda calculus and addresses both undergraduate students and researchers. We show how the tool can be used to support the students' understanding of functional programming and discuss general problems related to the process of building theorem proving software that aims at supporting both research and education.
Y1  - 2018
U6  - https://doi.org/10.4204/EPTCS.267.4
SN  - 2075-2180
IS  - 267
SP  - 59
EP  - 69
PB  - Open Publishing Association
CY  - Sydney
ER  - 
TY  - JOUR
A1  - Totz, Sonja Juliana
A1  - Eliseev, Alexey V.
A1  - Petri, Stefan
A1  - Flechsig, Michael
A1  - Caesar, Levke
A1  - Petoukhov, Vladimir
A1  - Coumou, Dim
T1  - The dynamical core of the Aeolus 1.0 statistical-dynamical atmosphere model
BT  - validation and parameter optimization
JF  - Geoscientific model development : an interactive open access journal of the European Geosciences Union
N2  - Here, we present novel equations for the large-scale zonal-mean wind as well as those for planetary waves. Together with synoptic parameterization (as presented by Coumou et al., 2011), these form the mathematical description of the dynamical core of Aeolus 1.0. The regions of high azonal wind velocities (planetary waves) are accurately captured for all validation experiments. The zonal-mean zonal wind and the integrated lower troposphere mass flux show good results in particular in the Northern Hemisphere. In the Southern Hemisphere, the model tends to produce too-weak zonal-mean zonal winds and a too-narrow Hadley circulation. We discuss possible reasons for these model biases as well as planned future model improvements and applications.
Y1  - 2018
U6  - https://doi.org/10.5194/gmd-11-665-2018
SN  - 1991-959X
SN  - 1991-9603
VL  - 11
IS  - 2
SP  - 665
EP  - 679
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Weithoff, Guntram
A1  - Taube, Anne
A1  - Bolius, Sarah
T1  - The invasion success of the cyanobacterium Cylindrospermopsis raciborskii in experimental mesocosms
BT  - genetic identity, grazing loss, competition and biotic resistance
JF  - Aquatic Invasions
N2  - The potentially toxic, invasive cyanobacterium Cylindrospermopsis raciborskii, originating from sub-tropical regions, has spread into temperate climate zones in almost all continents. Potential factors in its success are temperature, light and nutrient levels. Grazing losses through zooplankton have been measured in the laboratory but are typically not regarded as a factor in (failed) invasion success. In some potentially suitable lakes, C. raciborskii has never been found, although it is present in water bodies close by. Therefore, we tested the invasive potential of three different isolates introduced into natural plankton communities using laboratory mesocosm experiments under three grazing levels: ambient zooplankton densities, removal of large species using 100 mu m mesh and a ca. doubling of large species. Three C. raciborskii isolates originating from the same geographic region (North-East Germany) were added separately to the four replicates of each treatment and kept in semi-continuous cultures for 21 days. Two isolates disappeared from the mesocosms and were also not viable in filtered lake water indicating that the lake water itself or the switch from culture medium to lake water led to the decay of the inoculated C. raciborskii. Only one out of the three isolates persisted in the plankton communities at a rather low level and only in the treatment without larger zooplankton. This result demonstrates that under potentially suitable environmental conditions, top-down control from zooplankton might hamper the establishment of C. raciborskii. Non-metric multidimensional scaling showed distinct variation in resident phytoplankton communities between the different grazing levels, thus differential grazing impact shaped the resident community in different ways allowing C. raciborskii only to invade under competitive (= low grazing pressure) conditions. Furthermore, even after invasion failure, the temporary presence of C. raciborskii influenced the phytoplankton community.
KW  - alien species
KW  - Cyanobacteria
KW  - competitive resistance
KW  - consumptive resistance
KW  - herbivory
KW  - harmful algae
KW  - microbial invasion
Y1  - 2017
U6  - https://doi.org/10.3391/ai.2017.12.3.07
SN  - 1798-6540
SN  - 1818-5487
VL  - 12
SP  - 333
EP  - 341
PB  - Regional Euro-Asian Biological Invasions centre-reabic
CY  - Helsinki
ER  - 
TY  - JOUR
A1  - Vater, Aline
A1  - Moritz, Steffen
A1  - Roepke, Stefan
T1  - Does a narcissism epidemic exist in modern western societies?
BT  - Comparing narcissism and self-esteem in East and West Germany
JF  - PLOS ONE
N2  - Narcissism scores are higher in individualistic cultures compared with more collectivistic cultures. However, the impact of sociocultural factors on narcissism and self-esteem has not been well described. Germany was formerly divided into two different social systems, each with distinct economic, political and national cultures, and was reunified in 1989/90. Between 1949 and 1989/90, West Germany had an individualistic culture, whereas East Germany had a more collectivistic culture. The German reunification provides an exceptional opportunity to investigate the impact of sociocultural and generational differences on narcissism and self-esteem. In this study, we used an anonymous online survey to assess grandiose narcissism with the Narcissistic Personality Inventory (NPI) and the Pathological Narcissism Inventory (PNI) to assess grandiose and vulnerable aspects of narcissism, and self-esteem with the Rosenberg Self-Esteem Scale (RSE) in 1,025 German individuals. Data were analyzed according to age and place of birth. Our results showed that grandiose narcissism was higher and self-esteem was lower in individuals who grew up in former West Germany compared with former East Germany. Further analyses indicated no significant differences in grandiose narcissism, vulnerable narcissism or self-esteem in individuals that entered school after the German reunification (≤ 5 years of age in 1989). In the middle age cohort (6–18 years of age in 1989), significant differences in vulnerable narcissism, grandiose narcissism and self-esteem were observed. In the oldest age cohort (> 19 years of age in 1989), significant differences were only found in one of the two scales assessing grandiose narcissism (NPI). Our data provides empirical evidence that sociocultural factors are associated with differences in narcissism and self-esteem.
Y1  - 2018
U6  - https://doi.org/10.1371/journal.pone.0188287
SN  - 1932-6203
VL  - 13
IS  - 1
PB  - Public Library of Science
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Wolf, Isabell Ann-Cathrin
A1  - Gilles, Maria
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Seibert, Julia
A1  - Jennen-Steinmetz, Christine
A1  - Krumm, Bertram
A1  - Rietschel, Marcella
A1  - Deuschle, Michael
A1  - Laucht, Manfred
T1  - Impact of prenatal stress on mother-infant dyadic behavior during the still-face paradigm
JF  - Borderline Personality Disorder and Emotion Dysregulation : the official journal of the National Education Alliance for Borderline Personality Disorder (NEA.BPD) and Dachverband Dialektisch Behaviorale Therapie (DDBT)
N2  - Background:
Mother-infant interaction provides important training for the infant’s ability to cope with stress and the development of resilience. Prenatal stress (PS) and its impact on the offspring’s development have long been a focus of stress research, with studies highlighting both harmful and beneficial effects. The aim of the current study was to examine the possible influence of both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy with mother-child dyadic behavior following stress exposure.
Methods:
The behavior of 164 mother-infant dyads during the still-face situation was filmed at six months postpartum and coded into three dyadic patterns: 1) both positive, 2) infant protesting-mother positive, and 3) infant protesting-mother negative. PS exposure was assessed prenatally according to psychological measures (i.e., psychopathological, perceived and psychosocial PS; n = 164) and HPA axis activity measures (maternal salivary cortisol, i.e., cortisol decline and area under the curve with respect to ground (AUCg); n = 134).
Results:
Mother-infant dyads in both the high- and low-stress groups showed decreasing positive and increasing negative dyadic behavior in the reunion episode, which is associated with the well-known “still-face” and “carry-over” effect. Furthermore, mother-infant dyads with higher psychosocial PS exhibited significantly more positive dyadic behavior than the low psychosocial PS group in the first play episode, but not in the reunion episode. Similarly, mother-infant dyads with high HPA axis activity (i.e. high AUCg) but steeper diurnal cortisol decline (i.e. cortisol decline) displayed significantly less negative behavior in the reunion episode than dyads with low HPA axis activity. No significant results were found for psychopathological stress and perceived stress.
Conclusions:
The results suggest a beneficial effect of higher psychosocial PS and higher prenatal maternal HPA axis activity in late gestation, which is in line with “stress inoculation” theories.
KW  - Prenatal stress
KW  - Face-to-face still-face paradigm
KW  - Resilience
KW  - Psychosocial stress
KW  - Cortisol
Y1  - 2018
U6  - https://doi.org/10.1186/s40479-018-0078-8
SN  - 2051-6673
VL  - 5
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Bukowski, Alexandra R.
A1  - Schittko, Conrad
A1  - Petermann, Jana S.
T1  - The strength of negative plant-soil feedback increases from the intraspecific to the interspecific and the functional group level
JF  - Ecology and evolution
N2  - One of the processes that may play a key role in plant species coexistence and ecosystem functioning is plant-soil feedback, the effect of plants on associated soil communities and the resulting feedback on plant performance. Plant-soil feedback at the interspecific level (comparing growth on own soil with growth on soil from different species) has been studied extensively, while plant-soil feedback at the intraspecific level (comparing growth on own soil with growth on soil from different accessions within a species) has only recently gained attention. Very few studies have investigated the direction and strength of feedback among different taxonomic levels, and initial results have been inconclusive, discussing phylogeny, and morphology as possible determinants. To test our hypotheses that the strength of negative feedback on plant performance increases with increasing taxonomic level and that this relationship is explained by morphological similarities, we conducted a greenhouse experiment using species assigned to three taxonomic levels (intraspecific, interspecific, and functional group level). We measured certain fitness-related aboveground traits and used them along literature-derived traits to determine the influence of morphological similarities on the strength and direction of the feedback. We found that the average strength of negative feedback increased from the intraspecific over the interspecific to the functional group level. However, individual accessions and species differed in the direction and strength of the feedback. None of our results could be explained by morphological dissimilarities or individual traits. Synthesis. Our results indicate that negative plant-soil feedback is stronger if the involved plants belong to more distantly related species. We conclude that the taxonomic level is an important factor in the maintenance of plant coexistence with plant-soil feedback as a potential stabilizing mechanism and should be addressed explicitly in coexistence research, while the traits considered here seem to play a minor role.
KW  - Arabidopsis thaliana Col-0
KW  - home-away effect
KW  - intraspecific diversity
KW  - morphological similarities
KW  - dissimilarities of plants
KW  - plant-soil (belowground) interactions
KW  - species coexistence
KW  - taxonomic levels
KW  - trait measurements
Y1  - 2018
U6  - https://doi.org/10.1002/ece3.3755
SN  - 2045-7758
VL  - 8
IS  - 4
SP  - 2280
EP  - 2289
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Küçükgöze, Gökhan
A1  - Leimkühler, Silke
T1  - Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities
JF  - PLOS ONE
N2  - Mammalian aldehyde oxidases (AOXs) are molybdo-flavoenzymes which are present in many tissues in various mammalian species, including humans and rodents. Different species contain a different number of AOX isoforms. In particular, the reasons why mammals other than humans express a multiplicity of tissue-specific AOX enzymes is unknown. In mouse, the isoforms mAOX1, mAOX3, mAOX4 and mAOX2 are present. We previously established a codon-optimized heterologous expression systems for the mAOX1-4 isoforms in Escherichia coli that gives yield to sufficient amounts of active protein for kinetic characterizations and sets the basis in this study for site-directed mutagenesis and structure-function studies. A direct and simultaneous comparison of the enzymatic properties and characteristics of the four enzymes on a larger number of substrates has never been performed. Here, thirty different structurally related aromatic, aliphatic and N-heterocyclic compounds were used as substrates, and the kinetic parameters of all four mAOX enzymes were directly compared. The results show that especially mAOX4 displays a higher substrate selectivity, while no major differences between mAOX1, mAOX2 and mAOX3 were identified. Generally, mAOX1 was the enzyme with the highest catalytic turnover for most substrates. To understand the factors that contribute to the substrate specificity of mAOX4, site-directed mutagenesis was applied to substitute amino acids in the substrate-binding funnel by the ones present in mAOX1, mAOX3, and mAOX2. An increase in activity was obtained by the amino acid exchange M1088V in the active site identified to be specific for mAOX4, to the amino acid identified in mAOX3.
Y1  - 2018
U6  - https://doi.org/10.1371/journal.pone.0191819
SN  - 1932-6203
VL  - 13
IS  - 1
PB  - Public Library of Science
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Lara, Mark J.
A1  - Nitze, Ingmar
A1  - Grosse, Guido
A1  - Martin, Philip
A1  - McGuire, A. David
T1  - Reduced arctic tundra productivity linked with landform and climate change interactions
JF  - Scientific reports
N2  - Arctic tundra ecosystems have experienced unprecedented change associated with climate warming over recent decades. Across the Pan-Arctic, vegetation productivity and surface greenness have trended positively over the period of satellite observation. However, since 2011 these trends have slowed considerably, showing signs of browning in many regions. It is unclear what factors are driving this change and which regions/landforms will be most sensitive to future browning. Here we provide evidence linking decadal patterns in arctic greening and browning with regional climate change and local permafrost-driven landscape heterogeneity. We analyzed the spatial variability of decadal-scale trends in surface greenness across the Arctic Coastal Plain of northern Alaska (similar to 60,000 km(2)) using the Landsat archive (1999-2014), in combination with novel 30 m classifications of polygonal tundra and regional watersheds, finding landscape heterogeneity and regional climate change to be the most important factors controlling historical greenness trends. Browning was linked to increased temperature and precipitation, with the exception of young landforms (developed following lake drainage), which will likely continue to green. Spatiotemporal model forecasting suggests carbon uptake potential to be reduced in response to warmer and/or wetter climatic conditions, potentially increasing the net loss of carbon to the atmosphere, at a greater degree than previously expected.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-20692-8
SN  - 2045-2322
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Dai, Xiaolin
A1  - Mate, Diana M.
A1  - Glebe, Ulrich
A1  - Garakani, Tayebeh Mirzaei
A1  - Körner, Andrea
A1  - Schwaneberg, Ulrich
A1  - Böker, Alexander
T1  - Sortase-mediated ligation of purely artificial building blocks
JF  - Polymers
N2  - Sortase A (SrtA) from Staphylococcus aureus has been often used for ligating a protein with other natural or synthetic compounds in recent years. Here we show that SrtA-mediated ligation (SML) is universally applicable for the linkage of two purely artificial building blocks. Silica nanoparticles (NPs), poly(ethylene glycol) and poly(N-isopropyl acrylamide) are chosen as synthetic building blocks. As a proof of concept, NP-polymer, NP-NP, and polymer-polymer structures are formed by SrtA catalysis. Therefore, the building blocks are equipped with the recognition sequence needed for SrtA reaction-the conserved peptide LPETG-and a pentaglycine motif. The successful formation of the reaction products is shown by means of transmission electron microscopy (TEM), matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-ToF MS), and dynamic light scattering (DLS). The sortase catalyzed linkage of artificial building blocks sets the stage for the development of a new approach to link synthetic structures in cases where their synthesis by established chemical methods is complicated.
KW  - sortase-mediated ligation
KW  - enzymes
KW  - block copolymers
KW  - nanoparticles
Y1  - 2018
U6  - https://doi.org/10.3390/polym10020151
SN  - 2073-4360
VL  - 10
IS  - 2
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Krapf, Diego
A1  - Marinari, Enzo
A1  - Metzler, Ralf
A1  - Oshanin, Gleb
A1  - Xu, Xinran
A1  - Squarcini, Alessio
T1  - Power spectral density of a single Brownian trajectory
BT  - what one can and cannot learn from it
JF  - New journal of physics : the open-access journal for physics
N2  - The power spectral density (PSD) of any time-dependent stochastic processX (t) is ameaningful feature of its spectral content. In its text-book definition, the PSD is the Fourier transform of the covariance function of X-t over an infinitely large observation timeT, that is, it is defined as an ensemble-averaged property taken in the limitT -> infinity. Alegitimate question is what information on the PSD can be reliably obtained from single-trajectory experiments, if one goes beyond the standard definition and analyzes the PSD of a single trajectory recorded for a finite observation timeT. In quest for this answer, for a d-dimensional Brownian motion (BM) we calculate the probability density function of a single-trajectory PSD for arbitrary frequency f, finite observation time T and arbitrary number k of projections of the trajectory on different axes. We show analytically that the scaling exponent for the frequency-dependence of the PSD specific to an ensemble of BM trajectories can be already obtained from a single trajectory, while the numerical amplitude in the relation between the ensemble-averaged and single-trajectory PSDs is afluctuating property which varies from realization to realization. The distribution of this amplitude is calculated exactly and is discussed in detail. Our results are confirmed by numerical simulations and single-particle tracking experiments, with remarkably good agreement. In addition we consider a truncated Wiener representation of BM, and the case of a discrete-time lattice random walk. We highlight some differences in the behavior of a single-trajectory PSD for BM and for the two latter situations. The framework developed herein will allow for meaningful physical analysis of experimental stochastic trajectories.
KW  - power spectral density
KW  - single-trajectory analysis
KW  - probability density function
KW  - exact results
Y1  - 2018
U6  - https://doi.org/10.1088/1367-2630/aaa67c
SN  - 1367-2630
VL  - 20
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Goodwin, Guillaume C. H.
A1  - Mudd, Simon M.
A1  - Clubb, Fiona J.
T1  - Unsupervised detection of salt marsh platforms
BT  - a topographic method
JF  - Earth surface dynamics
N2  - Salt marshes filter pollutants, protect coastlines against storm surges, and sequester carbon, yet are under threat from sea level rise and anthropogenic modification. The sustained existence of the salt marsh ecosystem depends on the topographic evolution of marsh platforms. Quantifying marsh platform topography is vital for improving the management of these valuable landscapes. The determination of platform boundaries currently relies on supervised classification methods requiring near-infrared data to detect vegetation, or demands labour-intensive field surveys and digitisation. We propose a novel, unsupervised method to reproducibly isolate salt marsh scarps and platforms from a digital elevation model (DEM), referred to as Topographic Identification of Platforms (TIP). Field observations and numerical models show that salt marshes mature into subhorizontal platforms delineated by subvertical scarps. Based on this premise, we identify scarps as lines of local maxima on a slope raster, then fill landmasses from the scarps upward, thus isolating mature marsh platforms. We test the TIP method using lidar-derived DEMs from six salt marshes in England with varying tidal ranges and geometries, for which topographic platforms were manually isolated from tidal flats. Agreement between manual and unsupervised classification exceeds 94% for DEM resolutions of 1 m, with all but one site maintaining an accuracy superior to 90% for resolutions up to 3 m. For resolutions of 1 m, platforms detected with the TIP method are comparable in surface area to digitised platforms and have similar elevation distributions. We also find that our method allows for the accurate detection of local block failures as small as 3 times the DEM resolution. Detailed inspection reveals that although tidal creeks were digitised as part of the marsh platform, unsupervised classification categorises them as part of the tidal flat, causing an increase in false negatives and overall platform perimeter. This suggests our method may benefit from combination with existing creek detection algorithms. Fallen blocks and high tidal flat portions, associated with potential pioneer zones, can also lead to differences between our method and supervised mapping. Although pioneer zones prove difficult to classify using a topographic method, we suggest that these transition areas should be considered when analysing erosion and accretion processes, particularly in the case of incipient marsh platforms. Ultimately, we have shown that unsupervised classification of marsh platforms from high-resolution topography is possible and sufficient to monitor and analyse topographic evolution.
Y1  - 2018
U6  - https://doi.org/10.5194/esurf-6-239-2018
SN  - 2196-6311
SN  - 2196-632X
VL  - 6
IS  - 1
SP  - 239
EP  - 255
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Bridwell, David A.
A1  - Cavanagh, James F.
A1  - Collins, Anne G. E.
A1  - Nunez, Michael D.
A1  - Srinivasan, Ramesh
A1  - Stober, Sebastian
A1  - Calhoun, Vince D.
T1  - Moving Beyond ERP Components
BT  - a selective review of approaches to integrate EEG and behavior
JF  - Frontiers in human neuroscienc
N2  - Relationships between neuroimaging measures and behavior provide important clues about brain function and cognition in healthy and clinical populations. While electroencephalography (EEG) provides a portable, low cost measure of brain dynamics, it has been somewhat underrepresented in the emerging field of model-based inference. We seek to address this gap in this article by highlighting the utility of linking EEG and behavior, with an emphasis on approaches for EEG analysis that move beyond focusing on peaks or "components" derived from averaging EEG responses across trials and subjects (generating the event-related potential, ERP). First, we review methods for deriving features from EEG in order to enhance the signal within single-trials. These methods include filtering based on user-defined features (i.e., frequency decomposition, time-frequency decomposition), filtering based on data-driven properties (i.e., blind source separation, BSS), and generating more abstract representations of data (e.g., using deep learning). We then review cognitive models which extract latent variables from experimental tasks, including the drift diffusion model (DDM) and reinforcement learning (RL) approaches. Next, we discuss ways to access associations among these measures, including statistical models, data-driven joint models and cognitive joint modeling using hierarchical Bayesian models (HBMs). We think that these methodological tools are likely to contribute to theoretical advancements, and will help inform our understandings of brain dynamics that contribute to moment-to-moment cognitive function.
KW  - EEG
KW  - ERP
KW  - blind source separation
KW  - partial least squares
KW  - canonical correlations analysis
KW  - representational similarity analysis
KW  - deep learning
KW  - hierarchical Bayesian model
Y1  - 2018
U6  - https://doi.org/10.3389/fnhum.2018.00106
SN  - 1662-5161
VL  - 12
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Roder, Phillip
A1  - Hille, Carsten
T1  - Local tissue manipulation via a force- and pressure-controlled AFM micropipette for analysis of cellular processes
JF  - Scientific reports
N2  - Local manipulation of complex tissues at the single-cell level is challenging and requires excellent sealing between the specimen and the micromanipulation device. Here, biological applications for a recently developed loading technique for a force-and pressure-controlled fluidic force microscope micropipette are described. This technique allows for the exact positioning and precise spatiotemporal control of liquid delivery. The feasibility of a local loading technique for tissue applications was investigated using two fluorescent dyes, with which local loading behaviour could be optically visualised. Thus, homogeneous intracellular distribution of CellTracker Red and accumulation of SYTO 9 Green within nuclei was realised in single cells of a tissue preparation. Subsequently, physiological micromanipulation experiments were performed. Salivary gland tissue was pre-incubated with the Ca2+-sensitive dye OGB-1. An intracellular Ca2+ rise was then initiated at the single-cell level by applying dopamine via micropipette. When pre-incubating tissue with the nitric oxide (NO)-sensitive dye DAF-FM, NO release and intercellular NO diffusion was observed after local application of the NO donor SNP. Finally, local micromanipulation of a well-defined area along irregularly shaped cell surfaces of complex biosystems was shown for the first time for the fluidic force microscope micropipette. Thus, this technique is a promising tool for the investigation of the spatiotemporal effects of locally applied substances in complex tissues.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-24255-9
SN  - 2045-2322
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Reichetzeder, Christoph
A1  - Hocher, Berthold
T1  - DPP4 inhibition prevents AKI
T2  - Oncotarget
KW  - acute kidney injury
KW  - DPP-4 inhibitors
KW  - ischemia reperfusion injury
KW  - gliptins
KW  - Dipeptidyl peptidase IV
Y1  - 2017
U6  - https://doi.org/10.18632/oncotarget.20212
SN  - 1949-2553
VL  - 8
SP  - 64655
EP  - 64656
PB  - Impact Journals LLC
CY  - Orchard Park
ER  - 
TY  - JOUR
A1  - Goychuk, Igor
T1  - Sensing magnetic fields with magnetosensitive ion channels
JF  - Sensors
N2  - Magnetic nanoparticles are met across many biological species ranging from magnetosensitive bacteria, fishes, bees, bats, rats, birds, to humans. They can be both of biogenetic origin and due to environmental contamination, being either in paramagnetic or ferromagnetic state. The energy of such naturally occurring single-domain magnetic nanoparticles can reach up to 10-20 room k(B)T in the magnetic field of the Earth, which naturally led to supposition that they can serve as sensory elements in various animals. This work explores within a stochastic modeling framework a fascinating hypothesis of magnetosensitive ion channels with magnetic nanoparticles serving as sensory elements, especially, how realistic it is given a highly dissipative viscoelastic interior of living cells and typical sizes of nanoparticles possibly involved.
KW  - magnetic nanoparticles
KW  - ion channels
KW  - viscoelastic effects and anomalous diffusion
KW  - non-exponential statistics
KW  - influence of weak magnetic fields on living systems
Y1  - 2018
U6  - https://doi.org/10.3390/s18030728
SN  - 1424-8220
VL  - 18
IS  - 3
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Kleuser, Burkhard
T1  - Divergent role of sphingosine 1-phosphate in liver health and disease
JF  - International journal of molecular sciences
N2  - Two decades ago, sphingosine 1-phosphate (S1P) was discovered as a novel bioactive molecule that regulates a variety of cellular functions. The plethora of S1P-mediated effects is due to the fact that the sphingolipid not only modulates intracellular functions but also acts as a ligand of G protein-coupled receptors after secretion into the extracellular environment. In the plasma, S1P is found in high concentrations, modulating immune cell trafficking and vascular endothelial integrity. The liver is engaged in modulating the plasma S1P content, as it produces apolipoprotein M, which is a chaperone for the S1P transport. Moreover, the liver plays a substantial role in glucose and lipid homeostasis. A dysfunction of glucose and lipid metabolism is connected with the development of liver diseases such as hepatic insulin resistance, non-alcoholic fatty liver disease, or liver fibrosis. Recent studies indicate that S1P is involved in liver pathophysiology and contributes to the development of liver diseases. In this review, the current state of knowledge about S1P and its signaling in the liver is summarized with a specific focus on the dysregulation of S1P signaling in obesity-mediated liver diseases. Thus, the modulation of S1P signaling can be considered as a potential therapeutic target for the treatment of hepatic diseases.
KW  - sphingolipids
KW  - sphingosine kinase
KW  - fibrosis
KW  - non-alcoholic fatty liver disease
KW  - insulin resistance
KW  - liver fibrosis
Y1  - 2018
U6  - https://doi.org/10.3390/ijms19030722
SN  - 1422-0067
VL  - 19
IS  - 3
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Kayhan, Ezgi
A1  - Matthes, Daniel
A1  - Marriott Haresign, Ira
A1  - Bánki, Anna
A1  - Michel, Christine
A1  - Langeloh, Miriam
A1  - Wass, Sam
A1  - Hoehl, Stefanie
T1  - DEEP: A dual EEG pipeline for developmental hyperscanning studies
JF  - Developmental Cognitive Neuroscience
N2  - Cutting-edge hyperscanning methods led to a paradigm shift in social neuroscience. It allowed researchers to measure dynamic mutual alignment of neural processes between two or more individuals in naturalistic contexts. The ever-growing interest in hyperscanning research calls for the development of transparent and validated data analysis methods to further advance the field. We have developed and tested a dual electroencephalography (EEG) analysis pipeline, namely DEEP. Following the preprocessing of the data, DEEP allows users to calculate Phase Locking Values (PLVs) and cross-frequency PLVs as indices of inter-brain phase alignment of dyads as well as time-frequency responses and EEG power for each participant. The pipeline also includes scripts to control for spurious correlations. Our goal is to contribute to open and reproducible science practices by making DEEP publicly available together with an example mother-infant EEG hyperscanning dataset.
KW  - Developmental hyperscanning
KW  - Dual EEG analysis
KW  - Adult-child interaction
KW  - Phase Locking Value
KW  - PLV
KW  - Cross-frequency PLV
KW  - FieldTrip
Y1  - 2022
U6  - https://doi.org/10.1016/j.dcn.2022.101104
SN  - 1878-9307
VL  - 54
SP  - 1
EP  - 11
PB  - Elsevier
CY  - Amsterdam, Niederlande
ER  - 
TY  - JOUR
A1  - Costa Tomaz de Souza, Arthur
A1  - Ayzel, Georgy
A1  - Heistermann, Maik
T1  - Quantifying the location error of precipitation nowcasts
JF  - Advances in meteorology
N2  - In precipitation nowcasting, it is common to track the motion of precipitation in a sequence of weather radar images and to extrapolate this motion into the future. The total error of such a prediction consists of an error in the predicted location of a precipitation feature and an error in the change of precipitation intensity over lead time. So far, verification measures did not allow isolating the extent of location errors, making it difficult to specifically improve nowcast models with regard to location prediction. In this paper, we introduce a framework to directly quantify the location error. To that end, we detect and track scale-invariant precipitation features (corners) in radar images. We then consider these observed tracks as the true reference in order to evaluate the performance (or, inversely, the error) of any model that aims to predict the future location of a precipitation feature. Hence, the location error of a forecast at any lead time Delta t ahead of the forecast time t corresponds to the Euclidean distance between the observed and the predicted feature locations at t + Delta t. Based on this framework, we carried out a benchmarking case study using one year worth of weather radar composites of the German Weather Service. We evaluated the performance of four extrapolation models, two of which are based on the linear extrapolation of corner motion from t - 1 to t (LK-Lin1) and t - 4 to t (LK-Lin4) and the other two are based on the Dense Inverse Search (DIS) method: motion vectors obtained from DIS are used to predict feature locations by linear (DIS-Lin1) and Semi-Lagrangian extrapolation (DIS-Rot1). Of those four models, DIS-Lin1 and LK-Lin4 turned out to be the most skillful with regard to the prediction of feature location, while we also found that the model skill dramatically depends on the sinuosity of the observed tracks. The dataset of 376,125 detected feature tracks in 2016 is openly available to foster the improvement of location prediction in extrapolation-based nowcasting models.
KW  - inuosity
Y1  - 2020
U6  - https://doi.org/10.1155/2020/8841913
SN  - 1687-9309
SN  - 1687-9317
VL  - 2020
PB  - Hindawi
CY  - London
ER  - 
TY  - JOUR
A1  - Grubic, Mira
A1  - Wierzba, Marta
T1  - The German additive particle noch
BT  - testing the role of topic situations
JF  - Glossa : a journal of general linguistics
N2  - The particle noch (‘still’) can have an additive reading similar to auch (‘also’). We argue that both particles indicate that a previously partially answered QUD is re-opened to add a further answer. The particles differ in that the QUD, in the case of auch, can be re-opened with respect to the same topic situation, whereas noch indicates that the QUD is re-opened with respect to a new topic situation. This account predicts a difference in the accommodation behavior of the two particles. We present an experiment whose results are in line with this prediction.
KW  - additive particles
KW  - noch
KW  - auch
KW  - German
KW  - topic situation
KW  - semantics
KW  - experiments
Y1  - 2020
U6  - https://doi.org/10.5334/gjgl.1275
SN  - 2397-1835
VL  - 6
IS  - 1
PB  - Ubiquity Press
CY  - London
ER  - 
TY  - JOUR
A1  - Malass, Ihsane
A1  - Tarkhanov, Nikolaj Nikolaevič
T1  - A perturbation of the de Rham complex
T1  - Возмущение комплекса де Рама
JF  - Journal of Siberian Federal University : Mathematics & Physics
JF  - Žurnal Sibirskogo Federalʹnogo Universiteta : Matematika i fizika
N2  - We consider a perturbation of the de Rham complex on a compact manifold with boundary. This perturbation goes beyond the framework of complexes, and so cohomology does not apply to it. On the other hand, its curvature is "small", hence there is a natural way to introduce an Euler characteristic and develop a Lefschetz theory for the perturbation. This work is intended as an attempt to develop a cohomology theory for arbitrary sequences of linear mappings.
N2  - Рассмотрим возмущение комплекса де Рама на компактном многообразии с краем. Это возмущение выходит за рамки комплексов, и поэтому когомологии к нему не относятся. С другой стороны, его кривизна "мала", поэтому существует естественный способ ввести характеристику Эйлера и разработать теорию Лефшеца для возмущения. Данная работа предназначена для попытки разработать теорию когомологий для произвольных последовательностей линейных отображений.
KW  - de Rham complex
KW  - cohomology
KW  - Hodge theory
KW  - Neumann problem
KW  - комплекс де Рама
KW  - когомологии
KW  - теория Ходжа
KW  - проблема Неймана
Y1  - 2020
U6  - https://doi.org/10.17516/1997-1397-2020-13-5-519-532
SN  - 1997-1397
SN  - 2313-6022
VL  - 13
IS  - 5
SP  - 519
EP  - 532
PB  - Siberian Federal University
CY  - Krasnojarsk
ER  - 
TY  - JOUR
A1  - Tiedemann, Kim
A1  - Iobbi-Nivol, Chantal
A1  - Leimkühler, Silke
T1  - The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes
JF  - Molecules
N2  - The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the E. coli YdhV protein, which differs from bis-MGD solely by the absence of the nucleotides, now enables studying the role of the nucleotides of bis-MGD and bis-MPT cofactors in Moco insertion and the activity of molybdoenzymes in direct comparison. Using the well-known E. coli TMAO reductase TorA as a model enzyme for cofactor insertion, we were able to show that the GMP nucleotides of bis-MGD are crucial for the insertion of the bis-MGD cofactor into apo-TorA.
KW  - bis-MGD
KW  - chaperone
KW  - molybdenum cofactor
KW  - TMAO reductase
Y1  - 2022
U6  - https://doi.org/10.3390/molecules27092993
SN  - 1420-3049
VL  - 27
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel, Schweiz
ET  - 9
ER  - 
TY  - JOUR
A1  - Ouergui, Ibrahim
A1  - Delleli, Slaheddine
A1  - Bouassida, Anissa
A1  - Bouhlel, Ezdine
A1  - Chaabene, Helmi
A1  - Ardigò, Luca Paolo
A1  - Franchini, Emerson
T1  - Technical-tactical analysis of small combat games in male kickboxers
BT  - Effects of varied number of opponents and area size
JF  - BMC Sports Science, Medicine and Rehabilitation
N2  - Background: To handle the competition demands, sparring drills are used for specific technical–tactical training as well as physical–physiological conditioning in combat sports. While the effects of different area sizes and number of within-round sparring partners on physiological and perceptive responses in combats sports were examined in previous studies, technical and tactical aspects were not investigated. This study investigated the effect of different within-round sparring partners number (i.e., at a time; 1 vs. 1, 1 vs. 2, and 1 vs. 4) and area sizes (2 m × 2 m, 4 m × 4 m, and 6 m × 6 m) variation on the technical–tactical aspects of small combat games in kickboxing.

Method: Twenty male kickboxers (mean ± standard deviation, age: 20.3 ± 0.9 years), regularly competing in regional and national events randomly performed nine different kickboxing combats, lasting 2 min each. All combats were video recorded and analyzed using the software Dartfish.

Results: Results showed that the total number of punches was significantly higher in 1 versus 4 compared with 1 versus 1 (p = 0.011, d = 0.83). Further, the total number of kicks was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 0.99 and d = 0.83, respectively). Moreover, the total number of kick combinations was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 1.05 and d = 0.95, respectively). The same outcome was significantly lower in 2 m × 2 m compared with 4 m × 4 m and 6 m × 6 m areas (p = 0.010 and d = − 0.45; p < 0.001 and d = − 0.6, respectively). The number of block-and-parry was significantly higher in 1 versus 4 compared with 1 versus 1 (p < 0.001, d = 1.45) and 1 versus 2 (p = 0.046, d = 0.61) and in 2 m × 2 m compared with 4 m × 4 m and 6 × 6 m areas (p < 0.001; d = 0.47 and d = 0.66, respectively). Backwards lean actions occurred more often in 2 m × 2 m compared with 4 m × 4 m (p = 0.009, d = 0.53) and 6 m × 6 m (p = 0.003, d = 0.60). However, the number of foot defenses was significantly lower in 2 m × 2 m compared with 6 m × 6 m (p < 0.001, d = 1.04) and 4 m × 4 m (p = 0.004, d = 0.63). Additionally, the number of clinches was significantly higher in 1 versus 1 compared with 1 versus 2 (p = 0.002, d = 0.7) and 1 versus 4 (p = 0.034, d = 0.45).

Conclusions: This study provides practical insights into how to manipulate within-round sparring partners’ number and/or area size to train specific kickboxing technical–tactical fundamentals.
KW  - Martial arts
KW  - Time-motion analysis
KW  - Punch
KW  - Kick
KW  - Defensive actions
Y1  - 2021
U6  - https://doi.org/10.1186/s13102-021-00391-0
SN  - 2052-1847
N1  - Luca Paolo Ardigò and Emerson Franchini have contributed equally to this work.
IS  - 13
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Yarman, Aysu
A1  - Scheller, Frieder W.
T1  - How reliable is the electrochemical readout of MIP sensors?
JF  - Sensors
N2  - Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.
KW  - molecularly imprinted polymers
KW  - electropolymerization
KW  - direct electron
KW  - transfer
KW  - catalysis
KW  - redox marker
KW  - gate effect
Y1  - 2020
U6  - https://doi.org/10.3390/s20092677
SN  - 1424-8220
VL  - 20
IS  - 9
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Adam, Remi
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, Masanori
A1  - Arcaro, C
A1  - Armand, Catherine
A1  - Armstrong, T.
A1  - Egberts, Kathrin
T1  - Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance
JF  - Monthly Notices of the Royal Astronomical Society
N2  - We report on the detection of very high energy (VHE; E > 100 GeV) gamma-ray emission from the BL Lac objects KUV 00311-1938 and PKS 1440-389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE gamma-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311-1938 of z < 0.98 and of PKS 1440-389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311-1938 is constrained to 0.51 <= z < 0.98 and of PKS 1440-389 to 0.14 (sic) z < 0.53.
KW  - BL Lacertae objects: individual
KW  - galaxies: high-redshift
KW  - gamma-rays: general
KW  - Resolved and unresolved sources as a function of wavelength
Y1  - 2020
VL  - 494
IS  - 4
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Weithoff, Guntram
A1  - Bell, Elanor Margaret
T1  - Complex Trophic Interactions in an Acidophilic Microbial Community
JF  - Microorganisms
N2  - Extreme habitats often harbor specific communities that differ substantially from non-extreme habitats. In many cases, these communities are characterized by archaea, bacteria and protists, whereas the number of species of metazoa and higher plants is relatively low. In extremely acidic habitats, mostly prokaryotes and protists thrive, and only very few metazoa thrive, for example, rotifers. Since many studies have investigated the physiology and ecology of individual species, there is still a gap in research on direct, trophic interactions among extremophiles. To fill this gap, we experimentally studied the trophic interactions between a predatory protist (Actinophrys sol, Heliozoa) and its prey, the rotifers Elosa woralli and Cephalodella sp., the ciliate Urosomoida sp. and the mixotrophic protist Chlamydomonas acidophila (a green phytoflagellate, Chlorophyta). We found substantial predation pressure on all animal prey. High densities of Chlamydomonas acidophila reduced the predation impact on the rotifers by interfering with the feeding behaviour of A. sol. These trophic relations represent a natural case of intraguild predation, with Chlamydomonas acidophila being the common prey and the rotifers/ciliate and A. sol being the intraguild prey and predator, respectively. We further studied this intraguild predation along a resource gradient using Cephalodella sp. as the intraguild prey. The interactions among the three species led to an increase in relative rotifer abundance with increasing resource (Chlamydomonas) densities. By applying a series of laboratory experiments, we revealed the complexity of trophic interactions within a natural extremophilic community.
KW  - acid mine drainage
KW  - extremophiles
KW  - food web
KW  - heliozoa
KW  - intraguild predation
KW  - mining lakes
KW  - Rotifera
Y1  - 2022
U6  - https://doi.org/10.3390/microorganisms10071340
SN  - 2076-2607
VL  - 10
SP  - 1
EP  - 10
PB  - MDPI
CY  - Basel, Schweiz
ET  - 7
ER  - 
TY  - JOUR
A1  - Prasse, Paul
A1  - Iversen, Pascal
A1  - Lienhard, Matthias
A1  - Thedinga, Kristina
A1  - Herwig, Ralf
A1  - Scheffer, Tobias
T1  - Pre-Training on In Vitro and Fine-Tuning on Patient-Derived Data Improves Deep Neural Networks for Anti-Cancer Drug-Sensitivity Prediction
JF  - MDPI
N2  - Large-scale databases that report the inhibitory capacities of many combinations of candidate drug compounds and cultivated cancer cell lines have driven the development of preclinical drug-sensitivity models based on machine learning. However, cultivated cell lines have devolved from human cancer cells over years or even decades under selective pressure in culture conditions. Moreover, models that have been trained on in vitro data cannot account for interactions with other types of cells. Drug-response data that are based on patient-derived cell cultures, xenografts, and organoids, on the other hand, are not available in the quantities that are needed to train high-capacity machine-learning models. We found that pre-training deep neural network models of drug sensitivity on in vitro drug-sensitivity databases before fine-tuning the model parameters on patient-derived data improves the models’ accuracy and improves the biological plausibility of the features, compared to training only on patient-derived data. From our experiments, we can conclude that pre-trained models outperform models that have been trained on the target domains in the vast majority of cases.
KW  - deep neural networks
KW  - drug-sensitivity prediction
KW  - anti-cancer drugs
Y1  - 2022
U6  - https://doi.org/10.3390/cancers14163950
SN  - 2072-6694
VL  - 14
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel, Schweiz
ET  - 16
ER  - 
TY  - JOUR
A1  - Raju, Rajarshi Roy
A1  - Koetz, Joachim
T1  - Inner rotation of Pickering Janus emulsions
JF  - Nanomaterials : open access journal
N2  - Janus droplets were prepared by vortex mixing of three non-mixable liquids, i.e., olive oil, silicone oil and water, in the presence of gold nanoparticles (AuNPs) in the aqueous phase and magnetite nanoparticles (MNPs) in the olive oil. The resulting Pickering emulsions were stabilized by a red-colored AuNP layer at the olive oil/water interface and MNPs at the oil/oil interface. The core–shell droplets can be stimulated by an external magnetic field. Surprisingly, an inner rotation of the silicon droplet is observed when MNPs are fixed at the inner silicon droplet interface. This is the first example of a controlled movement of the inner parts of complex double emulsions by magnetic manipulation via interfacially confined magnetic nanoparticles.
KW  - Janus droplets
KW  - Pickering emulsions
KW  - magnetic manipulation
KW  - gold nanoparticles
KW  - magnetite nanoparticles
Y1  - 2021
U6  - https://doi.org/10.3390/nano11123312
SN  - 2079-4991
VL  - 11
IS  - 12
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Fuchs, Matthias
A1  - Grosse, Guido
A1  - Strauss, Jens
A1  - Günther, Frank
A1  - Grigoriev, Mikhail N.
A1  - Maximov, Georgy M.
A1  - Hugelius, Gustaf
T1  - Carbon and nitrogen pools in thermokarst-affected permafrost landscapes in Arctic Siberia
JF  - Biogeosciences
N2  - Ice-rich yedoma-dominated landscapes store considerable amounts of organic carbon (C) and nitrogen (N) and are vulnerable to degradation under climate warming. We investigate the C and N pools in two thermokarst-affected yedoma landscapes - on Sobo-Sise Island and on Bykovsky Peninsula in the north of eastern Siberia. Soil cores up to 3m depth were collected along geomorphic gradients and analysed for organic C and N contents. A high vertical sampling density in the profiles allowed the calculation of C and N stocks for short soil column intervals and enhanced understanding of within-core parameter variability. Profile-level C and N stocks were scaled to the landscape level based on landform classifications from 5 m resolution, multispectral RapidEye satellite imagery. Mean landscape C and N storage in the first metre of soil for Sobo-Sise Island is estimated to be 20.2 kg C m(-2) and 1.8 kg N m(-2) and for Bykovsky Peninsula 25.9 kg C m(-2) and 2.2 kg N m(-2). Radiocarbon dating demonstrates the Holocene age of thermokarst basin deposits but also suggests the presence of thick Holoceneage cover layers which can reach up to 2 m on top of intact yedoma landforms. Reconstructed sedimentation rates of 0.10-0.57 mm yr(-1) suggest sustained mineral soil accumulation across all investigated landforms. Both yedoma and thermokarst landforms are characterized by limited accumulation of organic soil layers (peat). We further estimate that an active layer deepening of about 100 cm will increase organic C availability in a seasonally thawed state in the two study areas by similar to 5.8 Tg (13.2 kg C m(-2)). Our study demonstrates the importance of increasing the number of C and N storage inventories in ice-rich yedoma and thermokarst environments in order to account for high variability of permafrost and thermokarst environments in pan-permafrost soil C and N pool estimates.
Y1  - 2018
U6  - https://doi.org/10.5194/bg-15-953-2018
SN  - 1726-4170
SN  - 1726-4189
VL  - 15
IS  - 3
SP  - 953
EP  - 971
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Sauermann, Antje
A1  - Höhle, Barbara
T1  - Word order in German child language and child-directed speech
BT  - a corpus analysis on the ordering of double objects in the German middlefield
JF  - Glossa: A Journal of General Linguistics
N2  - We report two corpus analyses to examine the impact of animacy, definiteness, givenness and type of referring expression on the ordering of double objects in the spontaneous speech of German-speaking two- to four-year-old children and the child-directed speech of their mothers. The first corpus analysis revealed that definiteness, givenness and type of referring expression influenced word order variation in child language and child-directed speech when the type of referring expression distinguished between pronouns and lexical noun phrases. These results correspond to previous child language studies in English (e.g., de Marneffe et al. 2012). Extending the scope of previous studies, our second corpus analysis examined the role of different pronoun types on word order. It revealed that word order in child language and child-directed speech was predictable from the types of pronouns used. Different types of pronouns were associated with different sentence positions but also showed a strong correlation to givenness and definiteness. Yet, the distinction between pronoun types diminished the effects of givenness so that givenness had an independent impact on word order only in child-directed speech but not in child language. Our results support a multi-factorial approach to word order in German. Moreover, they underline the strong impact of the type of referring expression on word order and suggest that it plays a crucial role in the acquisition of the factors influencing word order variation.
KW  - German
KW  - word order
KW  - corpus study
KW  - language acquisition
KW  - information structure
KW  - referring expression
Y1  - 2018
U6  - https://doi.org/10.5334/gjgl.281
SN  - 2397-1835
VL  - 3
IS  - 1
PB  - Ubiquity Press LTD
CY  - London
ER  - 
TY  - JOUR
A1  - Badalyan, Artavazd
A1  - Dierich, Marlen
A1  - Stiba, Konstanze
A1  - Schwuchow, Viola
A1  - Leimkühler, Silke
A1  - Wollenberger, Ulla
T1  - Electrical wiring of the aldehyde oxidoreductase PaoABC with a polymer containing osmium redox centers
BT  - biosensors for benzaldehyde and GABA
JF  - Biosensors
N2  - Biosensors for the detection of benzaldehyde and g-aminobutyric acid (GABA) are reported using aldehyde oxidoreductase PaoABC from Escherichia coli immobilized in a polymer containing bound low potential osmium redox complexes. The electrically connected enzyme already electrooxidizes benzaldehyde at potentials below −0.15 V (vs. Ag|AgCl, 1 M KCl). The pH-dependence of benzaldehyde oxidation can be strongly influenced by the ionic strength. The effect is similar with the soluble osmium redox complex and therefore indicates a clear electrostatic effect on the bioelectrocatalytic efficiency of PaoABC in the osmium containing redox polymer. At lower ionic strength, the pH-optimum is high and can be switched to low pH-values at high ionic strength. This offers biosensing at high and low pH-values. A “reagentless” biosensor has been formed with enzyme wired onto a screen-printed electrode in a flow cell device. The response time to addition of benzaldehyde is 30 s, and the measuring range is between 10–150 µM and the detection limit of 5 µM (signal to noise ratio 3:1) of benzaldehyde. The relative standard deviation in a series (n = 13) for 200 µM benzaldehyde is 1.9%. For the biosensor, a response to succinic semialdehyde was also identified. Based on this response and the ability to work at high pH a biosensor for GABA is proposed by coimmobilizing GABA-aminotransferase (GABA-T) and PaoABC in the osmium containing redox polymer.
KW  - redox polymer
KW  - aldehyde oxidoreductase
KW  - ionic strength
KW  - benzaldehyde
KW  - GABA
KW  - biosensor
Y1  - 2014
U6  - https://doi.org/10.3390/bios4040403
VL  - 4
IS  - 4
SP  - 403
EP  - 421
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Oguntunde, Philip G.
A1  - Abiodun, Babatunde Joseph
A1  - Lischeid, Gunnar
A1  - Abatan, Abayomi A.
T1  - Droughts projection over the Niger and Volta River basins of West Africa at specific global warming levels
JF  - International Journal of Climatology
N2  - This study investigates possible impacts of four global warming levels (GWLs: GWL1.5, GWL2.0, GWL2.5, and GWL3.0) on drought characteristics over Niger River basin (NRB) and Volta River basin (VRB). Two drought indices-Standardized Precipitation Index (SPI) and Standardized Precipitation-Evapotranspiration Index (SPEI)-were employed in characterizing droughts in 20 multi-model simulation outputs from the Coordinated Regional Climate Downscaling Experiment (CORDEX). The performance of the simulation in reproducing basic hydro-climatological features and severe drought characteristics (i.e., magnitude and frequency) in the basins were evaluated. The projected changes in the future drought frequency were quantified and compared under the four GWLs for two climate forcing scenarios (RCP8.5 and RCP4.5). The regional climate model (RCM) ensemble gives a realistic simulation of historical hydro-climatological variables needed to calculate the drought indices. With SPEI, the simulation ensemble projects an increase in the magnitude and frequency of severe droughts over both basins (NRB and VRB) at all GWLs, but the increase, which grows with the GWLs, is higher over NRB than over VRB. More than 75% of the simulations agree on the projected increase at GWL1.5 and all simulations agree on the increase at higher GWLs. With SPI, the projected changes in severe drought is weaker and the magnitude remains the same at all GWLs, suggesting that SPI projection may underestimate impacts of the GWLs on the intensity and severity of future drought. The results of this study have application in mitigating impact of global warming on future drought risk over the regional water systems.
KW  - climate change
KW  - drought index
KW  - global warming levels
KW  - river basins
KW  - West Africa
KW  - CORDEX data
Y1  - 2019
VL  - 40
IS  - 13
PB  - John Wiley & Sons, Inc.
CY  - New Jersey
ER  - 
TY  - JOUR
A1  - Omane, Paul Okyere
A1  - Höhle, Barbara
T1  - Acquiring syntactic variability
BT  - The production of Wh-questions in children and adults speaking Akan
JF  - Frontiers in communication
N2  - This paper investigates the predictions of the Derivational Complexity Hypothesis by studying the acquisition of wh-questions in 4- and 5-year-old Akan-speaking children in an experimental approach using an elicited production and an elicited imitation task. Akan has two types of wh-question structures (wh-in-situ and wh-ex-situ questions), which allows an investigation of children’s acquisition of these two question structures and their preferences for one or the other. Our results show that adults prefer to use wh-ex-situ questions over wh-in-situ questions. The results from the children show that both age groups have the two question structures in their linguistic repertoire. However, they differ in their preferences in usage in the elicited production task: while the 5-year-olds preferred the wh-in-situ structure over the wh-ex-situ structure, the 4-year-olds showed a selective preference for the wh-in-situ structure in who-questions. These findings suggest a developmental change in wh-question preferences in Akan-learning children between 4 and 5 years of age with a so far unobserved u-shaped developmental pattern. In the elicited imitation task, all groups showed a strong tendency to maintain the structure of in-situ and ex-situ questions in repeating grammatical questions. When repairing ungrammatical ex-situ questions, structural changes to grammatical in-situ questions were hardly observed but the insertion of missing morphemes while keeping the ex-situ structure. Together, our findings provide only partial support for the Derivational Complexity Hypothesis.
KW  - Akan
KW  - wh-questions
KW  - wh-in-situ
KW  - wh-ex-situ
KW  - derivational complexity
KW  - language acquisition
Y1  - 2021
U6  - https://doi.org/10.3389/fcomm.2021.604951
SN  - 2297-900X
VL  - 2021
PB  - Frontiers Media
CY  - Lausanne,  Schweiz
ER  - 
TY  - JOUR
A1  - Reich, Eli
T1  - The return of liberal rabbinic education to Berlin
BT  - Abraham Geiger College, Zacharias Frankel College and the School of Jewish Theology
JF  - Nordisk judaistik = Scandinavian Jewish studies
N2  - In Berlin two rabbinical seminaries, a Reform and a Conservative, have recently been established. The historical and intellectual roots of these institutions in the nineteenth century is sketched, and then contrasted with the present curriculum and the religious profile of the students. Some theological questions for the future of these projects conclude the article.
KW  - Abraham Geiger College
KW  - Zacharias Frankel College
KW  - the School of Jewish Theology
KW  - rabbinic education in Berlin
Y1  - 2020
U6  - https://doi.org/10.30752/nj.84891
SN  - 0348-1646
SN  - 2343-4929
VL  - 31
IS  - 1
SP  - 87
EP  - 92
PB  - Donner Institute
CY  - Åbo
ER  - 
TY  - JOUR
A1  - Baumgardt, Iris
T1  - Berufliche Orientierung von Kindern im Grundschulalter
BT  - Analyse von ausgewählten Projekten, Unterrichtsmaterialien und Lehrplänen
N2  - Die berufliche Orientierung von Kindern im Grundschulalter ist bislang nur in Ansätzen erforscht. Gleichwohl gibt es berufsorientierende Angebote, die auf verschiedenen Ebenen Grundschulkinder adressieren. Die Untersuchung fokussiert aktuelle Forschungsergebnisse, ausgewählte Initiativen, Kinderbücher, Unterrichtsmaterialien usw. zur beruflichen Orientierung von Kindern. Mit dem Ziel der Entwicklung und Ausdifferenzierung eines facettenreichen beruflichen Selbstkonzeptes von Kindern werden spezifische Forschungs- und Entwicklungspotenziale aufgezeigt.
Y1  - 2022
SN  - 978-3-8340-2199-1
SN  - 978-3-7639-7188-6
U6  - https://doi.org/10.3278/9783763971886
PB  - Schneider Verlag Hohengehren GmbH
CY  - Baltmannsweiler
ER  - 
TY  - JOUR
A1  - Taffarello, Denise
A1  - Srinivasan, Raghavan
A1  - Samprogna Mohor, Guilherme
A1  - Bittencourt Guimaraes, Joao Luis
A1  - Calijuri, Maria do Carmo
A1  - Mendiondo, Eduardo Mario
T1  - Modeling freshwater quality scenarios with ecosystem-based adaptation in the headwaters of the Cantareira system, Brazil
JF  - Hydrology and earth system sciences : HESS
N2  - Although hydrologic models provide hypothesis testing of complex dynamics occurring at catchments, fresh-water quality modeling is still incipient at many subtropical headwaters. In Brazil, a few modeling studies assess freshwater nutrients, limiting policies on hydrologic ecosystem services. This paper aims to compare freshwater quality scenarios under different land-use and land-cover (LULC) change, one of them related to ecosystem-based adaptation (EbA), in Brazilian headwaters. Using the spatially semi-distributed Soil and Water Assessment Tool (SWAT) model, nitrate, total phosphorous (TP) and sediment were modeled in catchments ranging from 7.2 to 1037 km(2). These head-waters were eligible areas of the Brazilian payment for ecosystem services (PES) projects in the Cantareira water supply system, which had supplied water to 9 million people in the Sao Paulo metropolitan region (SPMR). We considered SWAT modeling of three LULC scenarios: (i) recent past scenario (S1), with historical LULC in 1990; (ii) current land-use scenario (S2), with LULC for the period 2010-2015 with field validation; and (iii) future land-use scenario with PES (S2 + EbA). This latter scenario proposed forest cover restoration through EbA following the river basin plan by 2035. These three LULC scenarios were tested with a selected record of rainfall and evapotranspiration observed in 2006-2014, with the occurrence of extreme droughts. To assess hydrologic services, we proposed the hydrologic service index (HSI), as a new composite metric comparing water pollution levels (WPL) for reference catchments, related to the grey water footprint (greyWF) and water yield. On the one hand, water quality simulations allowed for the regionalization of greyWF at spatial scales under LULC scenarios. According to the critical threshold, HSI identified areas as less or more sustainable catchments. On the other hand, conservation practices simulated through the S2 + EbA scenario envisaged not only additional and viable best management practices (BMP), but also preventive decision-making at the headwaters of water supply systems.
Y1  - 2018
U6  - https://doi.org/10.5194/hess-22-4699-2018
SN  - 1027-5606
SN  - 1607-7938
VL  - 22
IS  - 9
SP  - 4699
EP  - 4723
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Mitic, Kristina
A1  - Grafe, Marianne
A1  - Batsios, Petros
A1  - Meyer, Irene
T1  - Partial Disassembly of the Nuclear Pore Complex Proteins during Semi-Closed Mitosis in Dictyostelium discoideum
JF  - Cells
N2  - Dictyostelium cells undergo a semi-closed mitosis, during which the nuclear envelope (NE) persists; however, free diffusion between the cytoplasm and the nucleus takes place. To permit the formation of the mitotic spindle, the nuclear envelope must be permeabilized in order to allow diffusion of tubulin dimers and spindle assembly factors into the nucleus. In Aspergillus, free diffusion of proteins between the cytoplasm and the nucleus is achieved by a partial disassembly of the nuclear pore complexes (NPCs) prior to spindle assembly. In order to determine whether this is also the case in Dictyostelium, we analysed components of the NPC by immunofluorescence microscopy and live cell imaging and studied their behaviour during interphase and mitosis. We observed that the NPCs are absent from the contact area of the nucleoli and that some nucleoporins also localize to the centrosome and the spindle poles. In addition, we could show that, during mitosis, the central FG protein NUP62, two inner ring components and Gle1 depart from the NPCs, while all other tested NUPs remained at the NE. This leads to the conclusion that indeed a partial disassembly of the NPCs takes place, which contributes to permeabilisation of the NE during semi-closed mitosis.
KW  - nuclear pore complex
KW  - nucleoporins
KW  - semi-closed mitosis
KW  - centrosome
KW  - Dictyostelium
Y1  - 2021
U6  - https://doi.org/10.3390/cells11030407
SN  - 2073-4409
VL  - 11
IS  - 3
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Mattis, Toni
A1  - Beckmann, Tom
A1  - Rein, Patrick
A1  - Hirschfeld, Robert
T1  - First-class concepts
BT  - Reified architectural knowledge beyond dominant decompositions
JF  - Journal of object technology : JOT / ETH Zürich, Department of Computer Science
N2  - Ideally, programs are partitioned into independently maintainable and understandable modules. As a system grows, its architecture gradually loses the capability to accommodate new concepts in a modular way. While refactoring is expensive and not always possible, and the programming language might lack dedicated primary language constructs to express certain cross-cutting concerns, programmers are still able to explain and delineate convoluted concepts through secondary means: code comments, use of whitespace and arrangement of code, documentation, or communicating tacit knowledge. <br /> Secondary constructs are easy to change and provide high flexibility in communicating cross-cutting concerns and other concepts among programmers. However, such secondary constructs usually have no reified representation that can be explored and manipulated as first-class entities through the programming environment. <br /> In this exploratory work, we discuss novel ways to express a wide range of concepts, including cross-cutting concerns, patterns, and lifecycle artifacts independently of the dominant decomposition imposed by an existing architecture. We propose the representation of concepts as first-class objects inside the programming environment that retain the capability to change as easily as code comments. We explore new tools that allow programmers to view, navigate, and change programs based on conceptual perspectives. In a small case study, we demonstrate how such views can be created and how the programming experience changes from draining programmers' attention by stretching it across multiple modules toward focusing it on cohesively presented concepts. Our designs are geared toward facilitating multiple secondary perspectives on a system to co-exist in symbiosis with the original architecture, hence making it easier to explore, understand, and explain complex contexts and narratives that are hard or impossible to express using primary modularity constructs.
KW  - software engineering
KW  - modularity
KW  - exploratory programming
KW  - program
KW  - comprehension
KW  - remodularization
KW  - architecture recovery
Y1  - 2022
U6  - https://doi.org/10.5381/jot.2022.21.2.a6
SN  - 1660-1769
VL  - 21
IS  - 2
SP  - 1
EP  - 15
PB  - ETH Zürich, Department of Computer Science
CY  - Zürich
ER  - 
TY  - JOUR
A1  - Marcisz, Katarzyna
A1  - Jassey, Vincent E. J.
A1  - Kosakyan, Anush
A1  - Krashevska, Valentyna
A1  - Lahr, Daniel J. G.
A1  - Lara, Enrique
A1  - Lamentowicz, Lukasz
A1  - Lamentowicz, Mariusz
A1  - Macumber, Andrew
A1  - Mazei, Yuri
A1  - Mitchell, Edward A. D.
A1  - Nasser, Nawaf A.
A1  - Patterson, R. Timothy
A1  - Roe, Helen M.
A1  - Singer, David
A1  - Tsyganov, Andrey N.
A1  - Fournier, Bertrand
T1  - Testate amoeba functional traits and their use in paleoecology
JF  - Frontiers in Ecology and Evolution
N2  - This review provides a synthesis of current knowledge on the morphological and functional traits of testate amoebae, a polyphyletic group of protists commonly used as proxies of past hydrological changes in paleoecological investigations from peatland, lake sediment and soil archives. A trait-based approach to understanding testate amoebae ecology and paleoecology has gained in popularity in recent years, with research showing that morphological characteristics provide complementary information to the commonly used environmental inferences based on testate amoeba (morpho-)species data. We provide a broad overview of testate amoeba morphological and functional traits and trait-environment relationships in the context of ecology, evolution, genetics, biogeography, and paleoecology. As examples we report upon previous ecological and paleoecological studies that used trait-based approaches, and describe key testate amoebae traits that can be used to improve the interpretation of environmental studies. We also highlight knowledge gaps and speculate on potential future directions for the application of trait-based approaches in testate amoeba research.
KW  - protists
KW  - functional traits
KW  - morphological traits
KW  - ecology
KW  - peatlands
KW  - lakes
KW  - soils
KW  - trait-based approaches
Y1  - 2020
U6  - https://doi.org/10.3389/fevo.2020.575966
SN  - 2296-701X
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Grafe, Marianne
A1  - Hofmann, Phillip
A1  - Batsios, Petros
A1  - Meyer, Irene
A1  - Gräf, Ralph
T1  - In vivo assembly of a Dictyostelium lamin mutant induced by light, mechanical stress, and pH
JF  - Cells : open access journal
N2  - We expressedDictyosteliumlamin (NE81) lacking both a functional nuclear localization signal and a CAAX-box for C-terminal lipid modification. This lamin mutant assembled into supramolecular, three-dimensional clusters in the cytosol that disassembled at the onset of mitosis and re-assembled in late telophase, thus mimicking the behavior of the endogenous protein. As disassembly is regulated by CDK1-mediated phosphorylation at serine 122, we generated a phosphomimetic S122E mutant called GFP-NE81-S122E-Delta NLS Delta CLIM. Surprisingly, during imaging, the fusion protein assembled into cytosolic clusters, similar to the protein lacking the phosphomimetic mutation. Clusters disassembled again in the darkness. Assembly could be induced with blue but not green or near ultraviolet light, and it was independent of the fusion tag. Assembly similarly occurred upon cell flattening. Earlier reports and own observations suggested that both blue light and cell flattening could result in a decrease of intracellular pH. Indeed, keeping the cells at low pH also reversibly induced cluster formation. Our results indicate that lamin assembly can be induced by various stress factors and that these are transduced via intracellular acidification. Although these effects have been shown in a phosphomimetic CDK1 mutant of theDictyosteliumlamin, they are likely relevant also for wild-type lamin.
KW  - lamin
KW  - NE81
KW  - Dictyostelium
KW  - nuclear envelope
KW  - nuclear lamina
Y1  - 2020
U6  - https://doi.org/10.3390/cells9081834
SN  - 2073-4409
VL  - 9
IS  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Neumann, Bettina
A1  - Wollenberger, Ulla
T1  - Electrochemical biosensors employing natural and artificial heme peroxidases on semiconductors
JF  - Sensors
N2  - Heme peroxidases are widely used as biological recognition elements in electrochemical biosensors for hydrogen peroxide and phenolic compounds. Various nature-derived and fully synthetic heme peroxidase mimics have been designed and their potential for replacing the natural enzymes in biosensors has been investigated. The use of semiconducting materials as transducers can thereby offer new opportunities with respect to catalyst immobilization, reaction stimulation, or read-out. This review focuses on approaches for the construction of electrochemical biosensors employing natural heme peroxidases as well as various mimics immobilized on semiconducting electrode surfaces. It will outline important advances made so far as well as the novel applications resulting thereof.
KW  - electrochemical biosensors
KW  - heme
KW  - peroxidases
KW  - semiconductors
KW  - peroxidase mimics
Y1  - 2020
U6  - https://doi.org/10.3390/s20133692
SN  - 1424-8220
VL  - 20
IS  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - García Bonillas, Rodrigo
T1  - Viva Babel : Long live Babel
BT  - Rezension zu: Lisboa de Mello, Ana Maria; Andrade, Antonio. (eds.)., Translinguismo e Poéticas do Contemporâneo. - Rio de Janeiro: 7 Letras, 2019. - 194 p. - ISBN: 978-85-421-0848-4
JF  - Alea : estudos neolatinos
Y1  - 2021
U6  - https://doi.org/10.1590/1517-106X/2021232344350
SN  - 1517-106X
SN  - 1807-0299
VL  - 23
IS  - 2
SP  - 344
EP  - 350
PB  - Universidade Federal do Rio de Janeiro, Faculdade de Letras
CY  - Rio de Janeiro RJ
ER  - 
TY  - JOUR
A1  - Rose, Robert
A1  - Groeger, Lars
A1  - Hölzle, Katharina
T1  - The Emergence of Shared Leadership in Innovation Labs
JF  - Frontiers in Psychology
N2  - Implementing innovation laboratories to leverage intrapreneurship are an increasingly popular organizational practice. A typical feature in these creative environments are semi-autonomous teams in which multiple members collectively exert leadership influence, thereby challenging traditional command-and-control conceptions of leadership. An extensive body of research on the team-centric concept of shared leadership has recognized the potential for pluralized leadership structures in enhancing team effectiveness; however, little empirical work has been conducted in organizational contexts in which creativity is key. This study set out to explore antecedents of shared leadership and its influence on team creativity in an innovation lab. Building on extant shared leadership and innovation research, we propose antecedents customary to creative teamwork, that is, experimental culture, task reflexivity, and voice. Multisource data were collected from 104 team members and 49 evaluations of 29 coaches nested in 21 teams working in a prototypical innovation lab. We identify factors specific to creative teamwork that facilitate the emergence of shared leadership by providing room for experimentation, encouraging team members to speak up in the creative process, and cultivating a reflective application of entrepreneurial thinking. We provide specific exemplary activities for innovation lab teams to increase levels of shared leadership.
KW  - innovation laboratories
KW  - intrapreneurship
KW  - team creativity
KW  - shared leadership
KW  - social network analysis
Y1  - 2021
U6  - https://doi.org/10.3389/fpsyg.2021.685167
SN  - 1664-1078
VL  - 12
SP  - 1
EP  - 13
PB  - Frontiers in psychology
CY  - Lausanne, Schweiz
ER  -