TY - JOUR
A1 - Cheng, Feng
A1 - Dennis, Alice B.
A1 - Osuoha, Josephine Ijeoma
A1 - Canitz, Julia
A1 - Kirschbaum, Frank
A1 - Tiedemann, Ralph
T1 - A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha
JF - BMC genomics
N2 - Background
Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high-quality genome assembly and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular.
Results
A high-quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862 Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A Computational Analysis of gene Family Evolution (CAFE5) comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris.
Conclusions
We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolution, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.
KW - Campylomormyrus
KW - Pacbio sequencing
KW - Gene family
KW - Osteoglossomorpha
KW - Kv1
Y1 - 2023
U6 - https://doi.org/10.1186/s12864-023-09196-6
SN - 1471-2164
VL - 24
IS - 1
PB - BMC
CY - London
ER -
TY - JOUR
A1 - Cesca, Simone
A1 - Sugan, Monica
A1 - Rudzinski, Lukasz
A1 - Vajedian, Sanaz
A1 - Niemz, Peter
A1 - Plank, Simon
A1 - Petersen, Gesa
A1 - Deng, Zhiguo
A1 - Rivalta, Eleonora
A1 - Vuan, Alessandro
A1 - Linares, Milton Percy Plasencia
A1 - Heimann, Sebastian
A1 - Dahm, Torsten
T1 - Massive earthquake swarm driven by magmatic intrusion at the Bransfield Strait, Antarctica
JF - Communications earth and environment
N2 - An earthquake swarm affected the Bransfield Strait, Antarctica, a unique rift basin in transition from intra-arc rifting to ocean spreading. The swarm, counting similar to 85,000 volcano-tectonic earthquakes since August 2020, is located close to the Orca submarine volcano, previously considered inactive. Simultaneously, geodetic data reported up to similar to 11 cm north-westward displacement over King George Island. We use a broad variety of geophysical data and methods to reveal the complex migration of seismicity, accompanying the intrusion of 0.26-0.56 km(3) of magma. Strike-slip earthquakes mark the intrusion at depth, while shallower normal faulting the similar to 20 km long lateral growth of a dike. Seismicity abruptly decreased after a Mw 6.0 earthquake, suggesting the magmatic dike lost pressure with the slipping of a large fault. A seafloor eruption is likely, but not confirmed by sea surface temperature anomalies. The unrest documents episodic magmatic intrusion in the Bransfield Strait, providing unique insights into active continental rifting.
Y1 - 2022
U6 - https://doi.org/10.1038/s43247-022-00418-5
SN - 2662-4435
VL - 3
IS - 1
PB - Springer Nature
CY - London
ER -
TY - JOUR
A1 - Fehr, Jana
A1 - Piccininni, Marco
A1 - Kurth, Tobias
A1 - Konigorski, Stefan
T1 - Assessing the transportability of clinical prediction models for cognitive impairment using causal models
JF - BMC medical research methodology
N2 - Background
Machine learning models promise to support diagnostic predictions, but may not perform well in new settings. Selecting the best model for a new setting without available data is challenging. We aimed to investigate the transportability by calibration and discrimination of prediction models for cognitive impairment in simulated external settings with different distributions of demographic and clinical characteristics.
Methods
We mapped and quantified relationships between variables associated with cognitive impairment using causal graphs, structural equation models, and data from the ADNI study. These estimates were then used to generate datasets and evaluate prediction models with different sets of predictors. We measured transportability to external settings under guided interventions on age, APOE & epsilon;4, and tau-protein, using performance differences between internal and external settings measured by calibration metrics and area under the receiver operating curve (AUC).
Results
Calibration differences indicated that models predicting with causes of the outcome were more transportable than those predicting with consequences. AUC differences indicated inconsistent trends of transportability between the different external settings. Models predicting with consequences tended to show higher AUC in the external settings compared to internal settings, while models predicting with parents or all variables showed similar AUC.
Conclusions
We demonstrated with a practical prediction task example that predicting with causes of the outcome results in better transportability compared to anti-causal predictions when considering calibration differences. We conclude that calibration performance is crucial when assessing model transportability to external settings.
KW - Alzheimer's Disease
KW - Clinical risk prediction
KW - DAG
KW - Causality;
KW - Transportability
Y1 - 2023
U6 - https://doi.org/10.1186/s12874-023-02003-6
SN - 1471-2288
VL - 23
IS - 1
PB - BMC
CY - London
ER -
TY - JOUR
A1 - Welke, Robert-William
A1 - Sperber, Hannah Sabeth
A1 - Bergmann, Ronny
A1 - Koikkarah, Amit
A1 - Menke, Laura
A1 - Sieben, Christian
A1 - Krüger, Detlev H.
A1 - Chiantia, Salvatore
A1 - Herrmann, Andreas
A1 - Schwarzer, Roland
T1 - Characterization of hantavirus N protein intracellular dynamics and localization
JF - Viruses
N2 - Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome.
The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation, and several other crucial processes during hantavirus infection.
In this study, we generated fluorescently tagged N protein constructs derived from Puumalavirus (PUUV), the dominant hantavirus species in Central, Northern, and Eastern Europe.
We comprehensively characterized this protein in the rodent cell line CHO-K1, monitoring the dynamics of N protein complex formation and investigating co-localization with host proteins as well as the viral glycoproteins Gc and Gn.
We observed formation of large, fibrillar PUUV N protein aggregates, rapidly coalescing from early punctate and spike-like assemblies.
Moreover, we found significant spatial correlation of N with vimentin, actin, and P-bodies but not with microtubules. N constructs also co-localized with Gn and Gc albeit not as strongly as the glycoproteins associated with each other.
Finally, we assessed oligomerization of N constructs, observing efficient and concentration-dependent multimerization, with complexes comprising more than 10 individual proteins.
KW - hantavirus
KW - N protein
KW - oligomerization
KW - actin
KW - P-bodies
KW - vimentin
KW - Number and Brightness
KW - Puumalavirus
KW - macromolecular assemblies
Y1 - 2022
U6 - https://doi.org/10.3390/v14030457
SN - 1999-4915
VL - 14
IS - 3
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Teich, Paula
A1 - Fühner, Thea Heidi
A1 - Baehr, Florian
A1 - Puta, Christian
A1 - Granacher, Urs
A1 - Kliegl, Reinhold
T1 - Covid pandemic effects on the physical fitness of primary school children
BT - results of the german EMOTIKON project
JF - Sports Medicine - Open
N2 - BackgroundIn spring of 2020, the Sars-CoV-2 incidence rate increased rapidly in Germany and around the world. Throughout the next 2 years, schools were temporarily closed and social distancing measures were put in place to slow the spread of the Covid-19 virus. Did these social restrictions and temporary school lockdowns affect children's physical fitness? The EMOTIKON project annually tests the physical fitness of all third-graders in the Federal State of Brandenburg, Germany. The tests assess cardiorespiratory endurance (6-min-run test), coordination (star-run test), speed (20-m sprint test), lower (powerLOW, standing long jump test), and upper (powerUP, ball-push test) limbs muscle power, and static balance (one-legged stance test with eyes closed). A total of 125,893 children were tested in the falls from 2016 to 2022. Primary analyses focused on 98,510 keyage third-graders (i.e., school enrollment according to the legal key date, aged 8 to 9 years) from 515 schools. Secondary analyses included 27,383 older-than-keyage third-graders (i.e., OTK, delayed school enrollment or repetition of a grade, aged 9 to 10 years), who have been shown to exhibit lower physical fitness than expected for their age. Linear mixed models fitted pre-pandemic quadratic secular trends, and took into account differences between children and schools.ResultsThird-graders exhibited lower cardiorespiratory endurance, coordination, speed and powerUP in the Covid pandemic cohorts (2020-2022) compared to the pre-pandemic cohorts (2016-2019). Children's powerLOW and static balance were higher in the pandemic cohorts compared to the pre-pandemic cohorts. From 2020 to 2021, coordination, powerLOW and powerUP further declined. Evidence for some post-pandemic physical fitness catch-up was restricted to powerUP. Cohen's |ds| for comparisons of the pandemic cohorts 2020-2022 with pre-pandemic cohorts 2016-2019 ranged from 0.02 for powerLOW to 0.15 for coordination. Within the pandemic cohorts, keyage children exhibited developmental losses ranging from approximately 1 month for speed to 5 months for cardiorespiratory endurance. For powerLOW and static balance, the positive pandemic effects translate to developmental gains of 1 and 7 months, respectively. Pre-pandemic secular trends may account for some of the observed differences between pandemic and pre-pandemic cohorts, especially in powerLOW, powerUP and static balance. The pandemic further increased developmental delays of OTK children in cardiorespiratory endurance, powerUP and balance.ConclusionsThe Covid-19 pandemic was associated with declines in several physical fitness components in German third-graders. Pandemic effects are still visible in 2022. Health-related interventions should specifically target those physical fitness components that were negatively affected by the pandemic (cardiorespiratory endurance, coordination, speed).
KW - Sars-CoV-2
KW - Cohort study
KW - Cardiorespiratory endurance
KW - Muscle power
KW - Physical fitness
KW - Youth
KW - EMOTIKON
KW - Linear mixed models
Y1 - 2023
U6 - https://doi.org/10.1186/s40798-023-00624-1
SN - 2198-9761
VL - 9
IS - 1
PB - Springer
CY - New York
ER -
TY - JOUR
A1 - Michirev, Alexej
A1 - Kühne, Katharina
A1 - Lindemann, Oliver
A1 - Fischer, Martin H.
A1 - Raab, Markus
T1 - How to not induce SNAs
BT - the insufficiency of directional force
JF - PLoS one
N2 - People respond faster to smaller numbers in their left space and to larger numbers in their right space. Here we argue that movements in space contribute to the formation of spatial-numerical associations (SNAs). We studied the impact of continuous isometric forces along the horizontal or vertical cardinal axes on SNAs while participants performed random number production and arithmetic verification tasks. Our results suggest that such isometric directional force do not suffice to induce SNAs.
Y1 - 2023
U6 - https://doi.org/10.1371/journal.pone.0288038
SN - 1932-6203
VL - 18
IS - 6
PB - PLoS
CY - San Fransisco
ER -
TY - JOUR
A1 - Borýsek, Martin
T1 - In search of Ovidian hebrew
BT - a philological study of a lesser known modern hebrew translation of Ovid’s Metamorphoses
JF - Acta Universitatis Carolinae : AUC
N2 - This paper focuses on the first substantial translation of Ovid’s Metamorphoses into modern Hebrew, whose author was Yehoshua Friedman (1885–1934). The first part of the paper sets Friedman into the context of modern Hebrew classical philology and explores the character of his verse. The core of the text consists of three case studies of selected excerpts from Ovid’s story of Apollo and Daphne (Met. I, 456–465; 481–482; 545–552). Based on detailed linguistic and stylistic analysis of these texts, I argue that Friedman did not simply adopt a pre-existing linguistic register, but rather created an original Ovidian idiom that helped to win him lasting significance in the history of Hebrew translations from classical languages.
KW - Ovid’s Metamorphoses
KW - Yehoshua Friedman
KW - modern Hebrew literature
KW - classical translations
KW - Apollo and Daphne
Y1 - 2022
UR - https://karolinum.cz/casopis/auc-philologica/rocnik-2021/cislo-4/clanek-10183
U6 - https://doi.org/10.14712/24646830.2022.11
SN - 0567-8269
SN - 2464-6830
IS - 4
SP - 29
EP - 56
PB - Karolinum Press
CY - Prag
ER -
TY - JOUR
A1 - Rosin, Paul L.
A1 - Lai, Yu-Kun
A1 - Mould, David
A1 - Yi, Ran
A1 - Berger, Itamar
A1 - Doyle, Lars
A1 - Lee, Seungyong
A1 - Li, Chuan
A1 - Liu, Yong-Jin
A1 - Semmo, Amir
A1 - Shamir, Ariel
A1 - Son, Minjung
A1 - Winnemöller, Holger
T1 - NPRportrait 1.0: A three-level benchmark for non-photorealistic rendering of portraits
JF - Computational visual media
N2 - Recently, there has been an upsurge of activity in image-based non-photorealistic rendering (NPR), and in particular portrait image stylisation, due to the advent of neural style transfer (NST). However, the state of performance evaluation in this field is poor, especially compared to the norms in the computer vision and machine learning communities. Unfortunately, the task of evaluating image stylisation is thus far not well defined, since it involves subjective, perceptual, and aesthetic aspects. To make progress towards a solution, this paper proposes a new structured, three-level, benchmark dataset for the evaluation of stylised portrait images. Rigorous criteria were used for its construction, and its consistency was validated by user studies. Moreover, a new methodology has been developed for evaluating portrait stylisation algorithms, which makes use of the different benchmark levels as well as annotations provided by user studies regarding the characteristics of the faces. We perform evaluation for a wide variety of image stylisation methods (both portrait-specific and general purpose, and also both traditional NPR approaches and NST) using the new benchmark dataset.
KW - non-photorealistic rendering (NPR)
KW - image stylization
KW - style transfer
KW - portrait
KW - evaluation
KW - benchmark
Y1 - 2022
U6 - https://doi.org/10.1007/s41095-021-0255-3
SN - 2096-0433
SN - 2096-0662
VL - 8
IS - 3
SP - 445
EP - 465
PB - Springer Nature
CY - London
ER -
TY - JOUR
A1 - Córdoba, Sandra Correa
A1 - Tong, Hao
A1 - Burgos, Asdrubal
A1 - Zhu, Feng
A1 - Alseekh, Saleh
A1 - Fernie, Alisdair R.
A1 - Nikoloski, Zoran
T1 - Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism
JF - Nature Communications
N2 - The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism.
Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83%) of single lethal knock-outs and 75% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide associations with fluxes obtained by integrating the PLM in diel condition- and accession-specific models identify up to 65 candidate genes modulating A. thaliana lipid metabolism. Using mutant lines, we validate up to 40% of the candidates, paving the way for identification of metabolic gene function based on models capturing natural variability in metabolism.
KW - Biochemical networks
KW - Biochemical reaction networks
KW - Genetic models
KW - Plant molecular biology
Y1 - 2023
U6 - https://doi.org/10.1038/s41467-023-40644-9
SN - 2041-1723
VL - 14
IS - 1
PB - Springer Nature
CY - London
ER -
TY - JOUR
A1 - Tomowski, Maxi
A1 - Lozada-Gobilard, Sissi Donna
A1 - Jeltsch, Florian
A1 - Tiedemann, Ralph
T1 - Recruitment and migration patterns reveal a key role for seed banks in the meta-population dynamics of an aquatic plant
JF - Scientific reports
N2 - Progressive habitat fragmentation threatens plant species with narrow habitat requirements. While local environmental conditions define population growth rates and recruitment success at the patch level, dispersal is critical for population viability at the landscape scale. Identifying the dynamics of plant meta-populations is often confounded by the uncertainty about soil-stored population compartments. We combined a landscape-scale assessment of an amphibious plant's population structure with measurements of dispersal complexity in time to track dispersal and putative shifts in functional connectivity. Using 13 microsatellite markers, we analyzed the genetic structure of extant Oenanthe aquatica populations and their soil seed banks in a kettle hole system to uncover hidden connectivity among populations in time and space. Considerable spatial genetic structure and isolation-by-distance suggest limited gene flow between sites. Spatial isolation and patch size showed minor effects on genetic diversity. Genetic similarity found among extant populations and their seed banks suggests increased local recruitment, despite some evidence of migration and recent colonization. Results indicate stepping-stone dispersal across adjacent populations. Among permanent and ephemeral demes the resulting meta-population demography could be determined by source-sink dynamics. Overall, these spatiotemporal connectivity patterns support mainland-island dynamics in our system, highlighting the importance of persistent seed banks as enduring sources of genetic diversity.
Y1 - 2023
U6 - https://doi.org/10.1038/s41598-023-37974-5
SN - 2045-2322
VL - 13
IS - 1
PB - Springer Nature
CY - London
ER -
TY - JOUR
A1 - Arend, Marius
A1 - Zimmer, David
A1 - Xu, Rudan
A1 - Sommer, Frederik
A1 - Mühlhaus, Timo
A1 - Nikoloski, Zoran
T1 - Proteomics and constraint-based modelling reveal enzyme kinetic properties of Chlamydomonas reinhardtii on a genome scale
JF - Nature Communications
N2 - Metabolic engineering of microalgae offers a promising solution for sustainable biofuel production, and rational design of engineering strategies can be improved by employing metabolic models that integrate enzyme turnover numbers. However, the coverage of turnover numbers for Chlamydomonas reinhardtii, a model eukaryotic microalga accessible to metabolic engineering, is 17-fold smaller compared to the heterotrophic cell factory Saccharomyces cerevisiae. Here we generate quantitative protein abundance data of Chlamydomonas covering 2337 to 3708 proteins in various growth conditions to estimate in vivo maximum apparent turnover numbers. Using constrained-based modeling we provide proxies for in vivo turnover numbers of 568 reactions, representing a 10-fold increase over the in vitro data for Chlamydomonas. Integration of the in vivo estimates instead of in vitro values in a metabolic model of Chlamydomonas improved the accuracy of enzyme usage predictions. Our results help in extending the knowledge on uncharacterized enzymes and improve biotechnological applications of Chlamydomonas.
KW - Computational models
KW - Enzymes
KW - Proteomics
Y1 - 2023
U6 - https://doi.org/10.1038/s41467-023-40498-1
SN - 2041-1723
VL - 14
IS - 1
PB - Springer Nature
CY - London
ER -
TY - JOUR
A1 - Basler, Georg
A1 - Fernie, Alisdair R.
A1 - Nikoloski, Zoran
T1 - Advances in metabolic flux analysis toward genome-scale profiling of higher organisms
JF - Bioscience reports : communications and reviews in molecular and cellular biology
N2 - Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies.
Y1 - 2018
U6 - https://doi.org/10.1042/BSR20170224
SN - 0144-8463
SN - 1573-4935
VL - 38
PB - Portland Press (London)
CY - London
ER -
TY - JOUR
A1 - Pandey, Prashant K.
A1 - Yu, Jing
A1 - Omranian, Nooshin
A1 - Alseekh, Saleh
A1 - Vaid, Neha
A1 - Fernie, Alisdair R.
A1 - Nikoloski, Zoran
A1 - Laitinen, Roosa A. E.
T1 - Plasticity in metabolism underpins local responses to nitrogen in Arabidopsis thaliana populations
JF - Plant Direct
N2 - Nitrogen (N) is central for plant growth, and metabolic plasticity can provide a strategy to respond to changing N availability. We showed that two local A. thaliana populations exhibited differential plasticity in the compounds of photorespiratory and starch degradation pathways in response to three N conditions. Association of metabolite levels with growth-related and fitness traits indicated that controlled plasticity in these pathways could contribute to local adaptation and play a role in plant evolution.
KW - Arabidopsis thaliana
KW - natural variation
KW - nitrogen availability
KW - photorespiration
KW - plasticity
Y1 - 2019
U6 - https://doi.org/10.1002/pld3.186
SN - 2475-4455
VL - 3
IS - 11
PB - John Wiley & sonst LTD
CY - Chichester
ER -
TY - CHAP
A1 - Rojahn, Marcel
A1 - Gronau, Norbert
ED - Bui, Tung X.
T1 - Openness indicators for the evaluation of digital platforms between the launch and maturity phase
T2 - Proceedings of the 57th Annual Hawaii International Conference on System Sciences
N2 - In recent years, the evaluation of digital platforms has become an important focus in the field of information systems science. The identification of influential indicators that drive changes in digital platforms, specifically those related to openness, is still an unresolved issue. This paper addresses the challenge of identifying measurable indicators and characterizing the transition from launch to maturity in digital platforms. It proposes a systematic analytical approach to identify relevant openness indicators for evaluation purposes. The main contributions of this study are the following (1) the development of a comprehensive procedure for analyzing indicators, (2) the categorization of indicators as evaluation metrics within a multidimensional grid-box model, (3) the selection and evaluation of relevant indicators, (4) the identification and assessment of digital platform architectures during the launch-to-maturity transition, and (5) the evaluation of the applicability of the conceptualization and design process for digital platform evaluation.
KW - federated industrial platform ecosystems
KW - technologies
KW - business models
KW - data-driven artifacts
KW - design-science research
KW - digital platform openness
KW - evaluation
KW - morphological analysis
Y1 - 2024
SN - 978-0-99813-317-1
SP - 4516
EP - 4525
PB - Department of IT Management Shidler College of Business University of Hawaii
CY - Honolulu, HI
ER -
TY - JOUR
A1 - Miklashevsky, Alex
A1 - Kulkova, Elena
A1 - Michirev, Alexej
A1 - Jeglinski-Mende, Melinda A.
A1 - Bertonatti, Matias
T1 - Book review on: Raab, Markus: Judgment, decision-making, and embodied choices. -
London ; San Diego ; Cambridge, MA ; Oxford: Academic Press, 2020. - xv, 155 pages. - ISBN: 978-0-12-823523-2
JF - Frontiers in psychology
KW - embodied cognition
KW - decision making
KW - embodied choice
KW - book review
KW - mind-body
Y1 - 2021
U6 - https://doi.org/10.3389/fpsyg.2021.665728
SN - 1664-1078
VL - 12
PB - Frontiers Research Foundation
CY - Lausanne
ER -
TY - JOUR
A1 - González Hauck, Sué
A1 - Herrmann, Franziska
A1 - Hettihewa, Julian A.
A1 - Kraft, Dariush
A1 - Milas, Max
A1 - Springer, Stephanie
A1 - Weckner, Franka
T1 - Jurisdiction
BT - Who speaks international law?
JF - Zeitschrift für ausländisches öffentliches Recht und Völkerrecht
Y1 - 2022
U6 - https://doi.org/10.17104/0044-2348-2022-2-289
SN - 0044-2348
SN - 2942-3562
VL - 82
IS - 2
SP - 289
EP - 298
PB - C.H. Beck
CY - München
ER -
TY - JOUR
A1 - Kayler, Zachary E.
A1 - Premke, Katrin
A1 - Gessler, Arthur
A1 - Gessner, Mark O.
A1 - Griebler, Christian
A1 - Hilt, Sabine
A1 - Klemedtsson, Leif
A1 - Kuzyakov, Yakov
A1 - Reichstein, Markus
A1 - Siemens, Jan
A1 - Totsche, Kai-Uwe
A1 - Tranvik, Lars
A1 - Wagner, Annekatrin
A1 - Weitere, Markus
A1 - Grossart, Hans-Peter
T1 - Integrating Aquatic and Terrestrial Perspectives to Improve Insights Into Organic Matter Cycling at the Landscape Scale
JF - Frontiers in Earth Science
N2 - Across a landscape, aquatic-terrestrial interfaces within and between ecosystems are hotspots of organic matter (OM) mineralization. These interfaces are characterized by sharp spatio-temporal changes in environmental conditions, which affect OM properties and thus control OM mineralization and other transformation processes. Consequently, the extent of OM movement at and across aquatic-terrestrial interfaces is crucial in determining OM turnover and carbon (C) cycling at the landscape scale. Here, we propose expanding current concepts in aquatic and terrestrial ecosystem sciences to comprehensively evaluate OM turnover at the landscape scale. We focus on three main concepts toward explaining OM turnover at the landscape scale: the landscape spatiotemporal context, OM turnover described by priming and ecological stoichiometry, and anthropogenic effects as a disruptor of natural OM transfer magnitudes and pathways. A conceptual framework is introduced that allows for discussing the disparities in spatial and temporal scales of OM transfer, changes in environmental conditions, ecosystem connectivity, and microbial-substrate interactions. The potential relevance of priming effects in both terrestrial and aquatic systems is addressed. For terrestrial systems, we hypothesize that the interplay between the influx of OM, its corresponding elemental composition, and the elemental demand of the microbial communities may alleviate spatial and metabolic thresholds. In comparison, substrate level OM dynamics may be substantially different in aquatic systems due to matrix effects that accentuate the role of abiotic conditions, substrate quality, and microbial community dynamics. We highlight the disproportionate impact anthropogenic activities can have on OM cycling across the landscape. This includes reversing natural OM flows through the landscape, disrupting ecosystem connectivity, and nutrient additions that cascade across the landscape. This knowledge is crucial for a better understanding of OM cycling in a landscape context, in particular since terrestrial and aquatic compartments may respond differently to the ongoing changes in climate, land use, and other anthropogenic interferences.
KW - landscape connectivity
KW - organic matter mineralization
KW - priming effects
KW - ecological stoichiometry
KW - aquatic-terrestrial interfaces
KW - anthropogenic interferences
Y1 - 2019
U6 - https://doi.org/10.3389/feart.2019.00127
SN - 2296-6463
VL - 7
PB - Frontiers Research Foundation
CY - Lausanne
ER -
TY - JOUR
A1 - Schmidt, Sabrina
A1 - Reil, Daniela
A1 - Jeske, Kathrin
A1 - Drewes, Stephan
A1 - Rosenfeld, Ulrike
A1 - Fischer, Stefan
A1 - Spierling, Nastasja G.
A1 - Labutin, Anton
A1 - Heckel, Gerald
A1 - Jacob, Jens
A1 - Ulrich, Rainer G.
A1 - Imholt, Christian
T1 - Spatial and temporal dynamics and molecular evolution of Tula orthohantavirus in German vole populations
JF - Viruses / Molecular Diversity Preservation International (MDPI)
N2 - Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.
KW - rodents
KW - hantavirus
KW - monitoring
KW - population dynamics
KW - common vole
KW - field vole
KW - water vole
KW - phylogeny
KW - molecular evolution
Y1 - 2021
U6 - https://doi.org/10.3390/v13061132
SN - 1999-4915
VL - 13
IS - 6
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Jaiser, Ralf
A1 - Akperov, Mirseid
A1 - Timazhev, A.
A1 - Romanowsky, Erik
A1 - Handorf, Dörthe
A1 - Mokhov, I. I.
T1 - Linkages between arctic and mid-latitude weather and climate
BT - unraveling the impact of changing sea ice and sea surface temperatures during Winter
JF - Meteorologische Zeitschrift
N2 - The study addresses the question, if observed changes in terms of Arctic-midlatitude linkages during winter are driven by Arctic Sea ice decline alone or if the increase of global sea surface temperatures plays an additional role. We compare atmosphere-only model experiments with ECHAM6 to ERA-Interim Reanalysis data. The model sensitivity experiment is implemented as a set of four combinations of sea ice and sea surface temperature boundary conditions. Atmospheric circulation regimes are determined and evaluated in terms of their cyclone and blocking characteristics and changes in frequency during winter. As a prerequisite, ECHAM6 reproduces general features of circulation regimes very well. Tropospheric changes induced by the change of boundary conditions are revealed and further impacts on the large-scale circulation up into the stratosphere are investigated. In early winter, the observed increase of atmospheric blocking in the region between Scandinavia and the Urals are primarily related to the changes in sea surface temperatures. During late winter, we f nd a weakened polar stratospheric vortex in the reanalysis that further impacts the troposphere. In the model sensitivity study a climatologically weakened polar vortex occurs only if sea ice is reduced and sea surface temperatures are increased together. This response is delayed compared to the reanalysis. The tropospheric response during late winter is inconclusive in the model, which is potentially related to the weak and delayed response in the stratosphere. The model experiments do not reproduce the connection between early and late winter as interpreted from the reanalysis. Potentially explaining this mismatch, we identify a discrepancy of ECHAM6 to reproduce the weakening of the stratospheric polar vortex through blocking induced upward propagation of planetary waves.
KW - Weather regimes
KW - Blocking
KW - Cyclones
KW - Wave Propagation
KW - Stratosphere
Y1 - 2023
U6 - https://doi.org/10.1127/metz/2023/1154
SN - 0941-2948
SN - 1610-1227
VL - 32
IS - 3
SP - 173
EP - 194
PB - Schweizerbart
CY - Stuttgart
ER -
TY - JOUR
A1 - Mayer, Dennis
A1 - Lever, Fabiano
A1 - Picconi, David
A1 - Metje, Jan
A1 - Ališauskas, Skirmantas
A1 - Calegari, Francesca
A1 - Düsterer, Stefan
A1 - Ehlert, Christopher
A1 - Feifel, Raimund
A1 - Niebuhr, Mario
A1 - Manschwetus, Bastian
A1 - Kuhlmann, Marion
A1 - Mazza, Tommaso
A1 - Robinson, Matthew Scott
A1 - Squibb, Richard James
A1 - Trabattoni, Andrea
A1 - Wallner, Måns
A1 - Saalfrank, Peter
A1 - Wolf, Thomas J. A.
A1 - Gühr, Markus
T1 - Following excited-state chemical shifts in molecular ultrafast x-ray photoelectron spectroscopy
JF - Nature Communications
N2 - The conversion of photon energy into other energetic forms in molecules is accompanied by charge moving on ultrafast timescales. We directly observe the charge motion at a specific site in an electronically excited molecule using time-resolved x-ray photoelectron spectroscopy (TR-XPS). We extend the concept of static chemical shift from conventional XPS by the excited-state chemical shift (ESCS), which is connected to the charge in the framework of a potential model. This allows us to invert TR-XPS spectra to the dynamic charge at a specific atom. We demonstrate the power of TR-XPS by using sulphur 2p-core-electron-emission probing to study the UV-excited dynamics of 2-thiouracil. The method allows us to discover that a major part of the population relaxes to the molecular ground state within 220–250 fs. In addition, a 250-fs oscillation, visible in the kinetic energy of the TR-XPS, reveals a coherent exchange of population among electronic states.
Y1 - 2022
U6 - https://doi.org/10.1038/s41467-021-27908-y
SN - 2041-1723
VL - 13
PB - Springer Nature
CY - Berlin
ER -
TY - JOUR
A1 - Veh, Georg
A1 - Lützow, Natalie
A1 - Kharlamova, Varvara
A1 - Petrakov, Dmitry
A1 - Hugonnet, Romain
A1 - Korup, Oliver
T1 - Trends, Breaks, and Biases in the Frequency of Reported Glacier Lake Outburst Floods
JF - Earth's Future
N2 - Thousands of glacier lakes have been forming behind natural dams in high mountains following glacier retreat since the early 20th century. Some of these lakes abruptly released pulses of water and sediment with disastrous downstream consequences. Yet it remains unclear whether the reported rise of these glacier lake outburst floods (GLOFs) has been fueled by a warming atmosphere and enhanced meltwater production, or simply a growing research effort. Here we estimate trends and biases in GLOF reporting based on the largest global catalog of 1,997 dated glacier-related floods in six major mountain ranges from 1901 to 2017. We find that the positive trend in the number of reported GLOFs has decayed distinctly after a break in the 1970s, coinciding with independently detected trend changes in annual air temperatures and in the annual number of field-based glacier surveys (a proxy of scientific reporting). We observe that GLOF reports and glacier surveys decelerated, while temperature rise accelerated in the past five decades. Enhanced warming alone can thus hardly explain the annual number of reported GLOFs, suggesting that temperature-driven glacier lake formation, growth, and failure are weakly coupled, or that outbursts have been overlooked. Indeed, our analysis emphasizes a distinct geographic and temporal bias in GLOF reporting, and we project that between two to four out of five GLOFs on average might have gone unnoticed in the early to mid-20th century. We recommend that such biases should be considered, or better corrected for, when attributing the frequency of reported GLOFs to atmospheric warming.
Y1 - 2022
U6 - https://doi.org/10.1029/2021EF002426
SN - 2328-4277
VL - 10
SP - 1
EP - 14
PB - Wiley-Blackwell
CY - Hoboken, New Jersey
ET - 3
ER -
TY - JOUR
A1 - Agarwal, Saloni
A1 - Hamidizadeh, Mojdeh
A1 - Bier, Frank Fabian
T1 - Detection of reverse transcriptase LAMP-amplified nucleic acid from oropharyngeal viral swab samples using biotinylated DNA probes through a lateral flow assay
JF - Biosensors : open access journal
N2 - This study focuses on three key aspects: (a) crude throat swab samples in a viral transport medium (VTM) as templates for RT-LAMP reactions; (b) a biotinylated DNA probe with enhanced specificity for LFA readouts; and (c) a digital semi-quantification of LFA readouts. Throat swab samples from SARS-CoV-2 positive and negative patients were used in their crude (no cleaning or pre-treatment) forms for the RT-LAMP reaction. The samples were heat-inactivated but not treated for any kind of nucleic acid extraction or purification. The RT-LAMP (20 min processing time) product was read out by an LFA approach using two labels: FITC and biotin. FITC was enzymatically incorporated into the RT-LAMP amplicon with the LF-LAMP primer, and biotin was introduced using biotinylated DNA probes, specifically for the amplicon region after RT-LAMP amplification. This assay setup with biotinylated DNA probe-based LFA readouts of the RT-LAMP amplicon was 98.11% sensitive and 96.15% specific. The LFA result was further analysed by a smartphone-based IVD device, wherein the T-line intensity was recorded. The LFA T-line intensity was then correlated with the qRT-PCR Ct value of the positive swab samples. A digital semi-quantification of RT-LAMP-LFA was reported with a correlation coefficient of R2 = 0.702. The overall RT-LAMP-LFA assay time was recorded to be 35 min with a LoD of three RNA copies/µL (Ct-33). With these three advancements, the nucleic acid testing-point of care technique (NAT-POCT) is exemplified as a versatile biosensor platform with great potential and applicability for the detection of pathogens without the need for sample storage, transportation, or pre-processing.
KW - RT-LAMP
KW - LFA
KW - NAAT-LFA
KW - semi-quantitative
KW - surveillance-based diagnostics
Y1 - 2023
U6 - https://doi.org/10.3390/bios13110988
SN - 2079-6374
VL - 13
IS - 11
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Bouamra, Marwa
A1 - Zouhal, Hassane
A1 - Ratel, Sébastien
A1 - Makhlouf, Issam
A1 - Bezrati, Ikram
A1 - Chtara, Moktar
A1 - Behm, David George
A1 - Granacher, Urs
A1 - Chaouachi, Anis
T1 - Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity
JF - Frontiers in Physiology
N2 - The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50% resistance (RT) and 50% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 ± 0.9 years; body-mass-index (BMI): 31.2 ± 4.8 kg·m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 sets×12 runs at 80–110% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3–4 sets × 10 repetition maximum (RM) and CT (n = 13): 50% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth.
KW - weight loss
KW - adolescents
KW - high-intensity-interval training
KW - resistance training
KW - DXA
KW - matched time
Y1 - 2022
U6 - https://doi.org/10.3389/fphys.2022.869063
SN - 1664-042X
VL - 13
SP - 1
EP - 16
PB - Frontiers
CY - Lausanne, Schweiz
ER -
TY - JOUR
A1 - Heistermann, Maik
A1 - Bogena, Heye
A1 - Francke, Till
A1 - Güntner, Andreas
A1 - Jakobi, Jannis
A1 - Rasche, Daniel
A1 - Schrön, Martin
A1 - Döpper, Veronika
A1 - Fersch, Benjamin
A1 - Groh, Jannis
A1 - Patil, Amol
A1 - Pütz, Thomas
A1 - Reich, Marvin
A1 - Zacharias, Steffen
A1 - Zengerle, Carmen
A1 - Oswald, Sascha
T1 - Soil moisture observation in a forested headwater catchment: combining a dense cosmic-ray neutron sensor network with roving and hydrogravimetry at the TERENO site Wüstebach
JF - Earth system science data : ESSD
N2 - Cosmic-ray neutron sensing (CRNS) has become an effective method to measure soil moisture at a horizontal scale of hundreds of metres and a depth of decimetres. Recent studies proposed operating CRNS in a network with overlapping footprints in order to cover root-zone water dynamics at the small catchment scale and, at the same time, to represent spatial heterogeneity. In a joint field campaign from September to November 2020 (JFC-2020), five German research institutions deployed 15 CRNS sensors in the 0.4 km2 Wüstebach catchment (Eifel mountains, Germany). The catchment is dominantly forested (but includes a substantial fraction of open vegetation) and features a topographically distinct catchment boundary. In addition to the dense CRNS coverage, the campaign featured a unique combination of additional instruments and techniques: hydro-gravimetry (to detect water storage dynamics also below the root zone); ground-based and, for the first time, airborne CRNS roving; an extensive wireless soil sensor network, supplemented by manual measurements; and six weighable lysimeters. Together with comprehensive data from the long-term local research infrastructure, the published data set (available at https://doi.org/10.23728/b2share.756ca0485800474e9dc7f5949c63b872; Heistermann et al., 2022) will be a valuable asset in various research contexts: to advance the retrieval of landscape water storage from CRNS, wireless soil sensor networks, or hydrogravimetry; to identify scale-specific combinations of sensors and methods to represent soil moisture variability; to improve the understanding and simulation of land–atmosphere exchange as well as hydrological and hydrogeological processes at the hillslope and the catchment scale; and to support the retrieval of soil water content from airborne and spaceborne remote sensing platforms.
Y1 - 2022
U6 - https://doi.org/10.5194/essd-14-2501-2022
SN - 1866-3516
SN - 1866-3508
VL - 14
IS - 5
SP - 2501
EP - 2519
PB - Copernicus
CY - Katlenburg-Lindau
ER -
TY - JOUR
A1 - Jebabli, Nidhal
A1 - Zouhal, Hassane
A1 - Boullosa, Daniel
A1 - Govindasamy, Karuppasamy
A1 - Tourny, Claire
A1 - Hackney, Anthony C.
A1 - Granacher, Urs
A1 - Ben Abderrahman, Abderraouf
T1 - The effects of preferred music and its timing on performance, pacing, and psychophysiological responses during the 6-min test
JF - Journal of human kinetics
N2 - The aim of this study was to investigate the effects of listening to preferred music during a warm up or exercise, on performance during a 6-min all-out exercise test (6-MT) in young adult males. Twenty-five healthy males volunteered to participate in this study. Following a within subject design, participants performed three test conditions (MDT: music during the test; MDW: music during the warm-up; WM: without music) in random order. Outcomes included mean running speed over the 6-min test (MRS6), total distance covered (TDC), heart rate responses (HRpeak, HRmean), blood lactate (3-min after the test), and the rating of perceived exertion (RPE); additionally, feeling scale scores were recorded. Listening to preferred music during running resulted in significant TDC (Delta up arrow 10%, p=0.006, ES=0.80) and MRS6 (Delta up arrow 14%, p=0.012, ES=1.02) improvement during the 6-MT, improvement was also noted for the warm-up with music condition (TDC:Delta up arrow 8%, p=0.028, ES=0.63; MRS6:Delta up arrow 8%, p=0.032, ES=0.61). A similar reverse "J-shaped" pacing profile was detected during the three conditions. Blood lactate was lower in the MDT condition by 8% (p=0.01, ES=1.10), but not the MDW condition, compared to MW. In addition, no statistically significant differences were found between the test sessions for the HR, RPE, and feeling scale scores. In conclusion, listening to music during exercise testing would be more beneficial for optimal TDC and MRS6 performances compared to MDW and WM.
KW - rating of perceived exertion
KW - work-rate distribution
KW - blood lactate;
KW - aerobic exercise
Y1 - 2022
U6 - https://doi.org/10.2478/hukin-2022-0038
SN - 1640-5544
SN - 1899-7562
VL - 82
IS - 1
SP - 123
EP - 133
PB - Academy of Physical Education
CY - Katowice
ER -
TY - GEN
A1 - Reil, Daniela
A1 - Rosenfeld, Ulrike
A1 - Imholt, Christian
A1 - Schmidt, Sabrina
A1 - Ulrich, Rainer G.
A1 - Eccard, Jana
A1 - Jacob, Jens
T1 - Puumala hantavirus infections in bank vole populations
BT - host and virus dynamics in Central Europe
T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2 - Background
In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010–2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies.
Results
We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections.
Conclusions
Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 957
KW - Myodes glareolus
KW - population dynamics
KW - Puumala virus seroprevalence
KW - space use
KW - survival
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431232
SN - 1866-8372
IS - 957
ER -
TY - JOUR
A1 - Philipowski, Katharina
ED - Philipowski, Katharina
T1 - Medieval Forms of First-Person Narration I
BT - a Potentially Universal Format (Villa Vigoni Talks I)
T2 - Beiträge zur mediävistischen Erzählforschung
N2 - In many European vernacular literatures in the 13th and 16th centuries, texts with remarkable congruities clearly emerge. They are allegorical, their subject is worldly love, and they use the first person as their narrative form. The most popular would be the French ›Roman de la Rose‹, the Italian ›Vita Nuova‹ by Dante or the Spanish ›Libro de buen amor‹. German examples are the ›Minnelehre‹ by Johann of Constance or the anonymous ›Minneburg‹. Until now such texts have been classified as (Dream-) allegories, as courtly love (Minne) speeches, or also as (fictional or stylized) autobiographies. As a result, they have rarely, if ever, been compared with each other. The goal of our conferences is to facilitate interdisciplinary exchanges regarding these texts, especially as concerns poetological, narrative, and allegorical dimensions.
KW - Mediävistik
KW - Erzählforschung
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?https://ojs.uni-oldenburg.de/ojs/index.php/bme/issue/view/13
SN - 2568-9967
VL - 8
IS - Special Issue
PB - University of Oldenburg Press
CY - Oldenburg
ER -
TY - JOUR
A1 - Philipowski, Katharina
ED - Philipowski, Katharina
T1 - Einführende Bemerkungen zu Diskursivität und Narrativität
JF - Medieval Forms of First-Person Narration: Narrativity and Discoursivity (Villa Vigoni Talks II)
JF - Beiträge zur mediävistischen Erzählforschung
KW - Mediävistik
KW - Erzählforschung
Y1 - 2022
U6 - http://nbn-resolving.de/urn/resolver.pl?https://ojs.uni-oldenburg.de/ojs/index.php/bme/article/view/222
SN - 2568-9967
VL - 14
IS - Special Issue
SP - 1
EP - 12
PB - University of Oldenburg Press
CY - Oldenburg
ER -
TY - JOUR
A1 - Bereswill, Sarah
A1 - Gatz-Miller, Hannah
A1 - Su, Danyang
A1 - Tötzke, Christian
A1 - Kardjilov, Nikolay
A1 - Oswald, Sascha
A1 - Mayer, Klaus Ulrich
T1 - Coupling non-invasive imaging and reactive transport modeling to investigate water and oxygen dynamics in the root zone
JF - Vadose zone journal
N2 - Oxygen (O-2) availability in soils is vital for plant growth and productivity. The transport and consumption of O-2 in the root zone is closely linked to soil moisture content, the spatial distribution of roots, as well as structure and heterogeneity of the surrounding soil. In this study, we measure three-dimensional root system architecture and the spatiotemporal dynamics of soil moisture (& theta;) and O-2 concentrations in the root zone of maize (Zea mays) via non-invasive imaging, and then construct and parameterize a reactive transport model based on the experimental data. The combination of three non-invasive imaging methods allowed for a direct comparison of simulation results with observations at high spatial and temporal resolution. In three different modeling scenarios, we investigated how the results obtained for different levels of conceptual complexity in the model were able to match measured & theta; and O-2 concentration patterns. We found that the modeling scenario that considers heterogeneous soil structure and spatial variability of hydraulic parameters (permeability, porosity, and van Genuchten & alpha; and n), better reproduced the measured & theta; and O-2 patterns relative to a simple model with a homogenous soil domain. The results from our combined imaging and modeling analysis reveal that experimental O-2 and water dynamics can be reproduced quantitatively in a reactive transport model, and that O-2 and water dynamics are best characterized when conditions unique to the specific system beyond the distribution of roots, such as soil structure and its effect on water saturation and macroscopic gas transport pathways, are considered.
Y1 - 2023
U6 - https://doi.org/10.1002/vzj2.20268
SN - 1539-1663
VL - 22
IS - 5
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Tabatabaei, Iman
A1 - Alseekh, Saleh
A1 - Shahid, Mohammad
A1 - Leniak, Ewa
A1 - Wagner, Mateusz
A1 - Mahmoudi, Henda
A1 - Thushar, Sumitha
A1 - Fernie, Alisdair R.
A1 - Murphy, Kevin M.
A1 - Schmöckel, Sandra M.
A1 - Tester, Mark
A1 - Müller-Röber, Bernd
A1 - Skirycz, Aleksandra
A1 - Balazadeh, Salma
T1 - The diversity of quinoa morphological traits and seed metabolic composition
JF - Scientific data
N2 - Quinoa (Chenopodium quinoa Willd.) is an herbaceous annual crop of the amaranth family (Amaranthaceae). It is increasingly cultivated for its nutritious grains, which are rich in protein and essential amino acids, lipids, and minerals. Quinoa exhibits a high tolerance towards various abiotic stresses including drought and salinity, which supports its agricultural cultivation under climate change conditions. The use of quinoa grains is compromised by anti-nutritional saponins, a terpenoid class of secondary metabolites deposited in the seed coat; their removal before consumption requires extensive washing, an economically and environmentally unfavorable process; or their accumulation can be reduced through breeding. In this study, we analyzed the seed metabolomes, including amino acids, fatty acids, and saponins, from 471 quinoa cultivars, including two related species, by liquid chromatography - mass spectrometry. Additionally, we determined a large number of agronomic traits including biomass, flowering time, and seed yield. The results revealed considerable diversity between genotypes and provide a knowledge base for future breeding or genome editing of quinoa.
Y1 - 2022
U6 - https://doi.org/10.1038/s41597-022-01399-y
SN - 2052-4463
VL - 9
IS - 1
PB - Nature Research
CY - Berlin
ER -
TY - CHAP
A1 - Abujarour, Safa’a
A1 - Köster, Antonia
A1 - Krasnova, Hanna
A1 - Wiesche, Manuel
T1 - Technology as a source of power
BT - Exploring how ICT use contributes to the social inclusion of refugees in Germany
T2 - Proceedings of the 54th Hawaii International Conference on System Sciences
N2 - Since the beginning of the recent global refugee crisis, researchers have been tackling many of its associated aspects, investigating how we can help to alleviate this crisis, in particular, using ICTs capabilities. In our research, we investigated the use of ICT solutions by refugees to foster the social inclusion process in the host community. To tackle this topic, we conducted thirteen interviews with Syrian refugees in Germany. Our findings reveal different ICT usages by refugees and how these contribute to feeling empowered. Moreover, we show the sources of empowerment for refugees that are gained by ICT use. Finally, we identified the two types of social inclusion benefits that were derived from empowerment sources. Our results provide practical implications to different stakeholders and decision-makers on how ICT usage can empower refugees, which can foster the social inclusion of refugees, and what should be considered to support them in their integration effort.
KW - culture, identity, and inclusion
KW - empowerment
KW - ict
KW - refugees
KW - social inclusion
KW - technology
Y1 - 2021
UR - https://hdl.handle.net/10125/70936
SN - 978-0-9981331-4-0
U6 - https://doi.org/10.24251/HICSS.2021.322
SN - 2572-6862
SP - 2637
EP - 2646
ER -
TY - JOUR
A1 - Mattern, Maximilian
A1 - Reppert, Alexander von
A1 - Zeuschner, Steffen Peer
A1 - Herzog, Marc
A1 - Pudell, Jan-Etienne
A1 - Bargheer, Matias
T1 - Concepts and use cases for picosecond ultrasonics with x-rays
JF - Photoacoustics
N2 - This review discusses picosecond ultrasonics experiments using ultrashort hard x-ray probe pulses to extract the transient strain response of laser-excited nanoscopic structures from Bragg-peak shifts. This method provides direct, layer-specific, and quantitative information on the picosecond strain response for structures down to few-nm thickness. We model the transient strain using the elastic wave equation and express the driving stress using Gruneisen parameters stating that the laser-induced stress is proportional to energy density changes in the microscopic subsystems of the solid, i.e., electrons, phonons and spins. The laser-driven strain response can thus serve as an ultrafast proxy for local energy-density and temperature changes, but we emphasize the importance of the nanoscale morphology for an accurate interpretation due to the Poisson effect. The presented experimental use cases encompass ultrathin and opaque metal-heterostructures, continuous and granular nanolayers as well as negative thermal expansion materials, that each pose a challenge to established all-optical techniques.
KW - Picosecond ultrasonics
KW - Ultrafast x-ray diffraction
KW - Ultrafast x-ray
KW - scattering
KW - Ultrafast photoacoustics
KW - Nanoscale heat transfer
KW - Negative
KW - thermal expansion
Y1 - 2023
U6 - https://doi.org/10.1016/j.pacs.2023.100503
SN - 2213-5979
VL - 31
PB - Elsevier
CY - Amsterdam
ER -
TY - CHAP
A1 - Abendroth, Adrian
A1 - Bender, Benedict
A1 - Gronau, Norbert
T1 - The evolution of original ERP customization
BT - a systematic literature review of technical possibilities
T2 - Proceedings of the 26th International Conference on Enterprise Information Systems
N2 - Enterprise Resource Planning (ERP) system customization is often necessary because companies have unique processes that provide their competitive advantage. Despite new technological advances such as cloud computing or model-driven development, technical ERP customization options are either outdated or ambiguously formulated in the scientific literature. Using a systematic literature review (SLR) that analyzes 137 definitions from 26 papers, the result is an analysis and aggregation of technical customization types by providing clearance and aligning with future organizational needs. The results show a shift from ERP code modification in on-premises systems to interface and integration customization in cloud ERP systems, as well as emerging technological opportunities as a way for customers and key users to perform system customization. The study contributes by providing a clear understanding of given customization types and assisting ERP users and vendors in making customization decisions.
KW - Enterprise Resource Planning (ERP) System
KW - Customization
KW - Modification
KW - Tailoring
KW - Literature Review
Y1 - 2024
SN - 978-989-758-692-7
U6 - https://doi.org/10.5220/0012305500003690
SN - 2184-4992
VL - 1
SP - 17
EP - 27
PB - SCITEPRESS - Science and Technology Publications
CY - Setúbal
ER -
TY - JOUR
A1 - Vilk, Ohad
A1 - Aghion, Erez
A1 - Avgar, Tal
A1 - Beta, Carsten
A1 - Nagel, Oliver
A1 - Sabri, Adal
A1 - Sarfati, Raphael
A1 - Schwartz, Daniel K.
A1 - Weiß, Matthias
A1 - Krapf, Diego
A1 - Nathan, Ran
A1 - Metzler, Ralf
A1 - Assaf, Michael
T1 - Unravelling the origins of anomalous diffusion
BT - from molecules to migrating storks
JF - Physical review research / American Physical Society
N2 - Anomalous diffusion or, more generally, anomalous transport, with nonlinear dependence of the mean-squared displacement on the measurement time, is ubiquitous in nature. It has been observed in processes ranging from microscopic movement of molecules to macroscopic, large-scale paths of migrating birds. Using data from multiple empirical systems, spanning 12 orders of magnitude in length and 8 orders of magnitude in time, we employ a method to detect the individual underlying origins of anomalous diffusion and transport in the data. This method decomposes anomalous transport into three primary effects: long-range correlations (“Joseph effect”), fat-tailed probability density of increments (“Noah effect”), and nonstationarity (“Moses effect”). We show that such a decomposition of real-life data allows us to infer nontrivial behavioral predictions and to resolve open questions in the fields of single-particle tracking in living cells and movement ecology.
Y1 - 2022
U6 - https://doi.org/10.1103/PhysRevResearch.4.033055
SN - 2643-1564
VL - 4
IS - 3
PB - American Physical Society
CY - College Park, MD
ER -
TY - GEN
A1 - Paoli, Antonio
A1 - Moro, Tatiana
A1 - Lorenzetti, Silvio
A1 - Seiler, Jan
A1 - Lüthy, Fabian
A1 - Gross, Micah
A1 - Roggio, Federico
A1 - Chaabene, Helmi
A1 - Musumeci, Giuseppe
T1 - The “Journal of Functional Morphology and Kinesiology” Journal Club Series
BT - Resistance Training
T2 - Journal of Functional Morphology and Kinesiology
N2 - We are glad to introduce the Second Journal Club of Volume Five, Second Issue. This edition is focused on relevant studies published in the last few years in the field of resistance training, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.
Y1 - 2020
U6 - https://doi.org/10.3390/jfmk5020025
SN - 2411-5142
VL - 5
IS - 2
SP - 1
EP - 9
PB - MDPI
CY - Basel
ER -
TY - GEN
A1 - Bilgen, Isa
T1 - Freiheit und Nachhaltigkeit im Verfassungswandel
T2 - Verfassungsblog : on matters constitutional
N2 - Mit dem Klima wandelt sich auch notwendig die offene Gesellschaft. Und mit ihr wandelt sich wiederum auch die Verfassung(-sinterpretation). Periodisch wiederkehrende Gesundheits- und Sicherheitskrisen fordern eine dynamische Reaktion des Grundgesetzes auf mit ihnen einhergehende Probleme. In andauernden Krisen wie der Umweltkrise muss die Verfassung gleichzeitig in vielerlei Hinsicht nachhaltig sein. Dabei muss das, was wir unter Freiheit, Klima‑, Umwelt- oder Tierschutz verstehen, immer im Wandel bleiben.
Y1 - 2023
UR - https://verfassungsblog.de/freiheit-und-nachhaltigkeit-im-verfassungswandel/
U6 - https://doi.org/10.17176/20230617-231023-0
SN - 2366-7044
PB - Max Steinbeis Verfassungsblog gGmbH
CY - Berlin
ER -
TY - JOUR
A1 - Mattern, Maximilian
A1 - Pudell, Jan-Etienne
A1 - Dumesnil, Karine
A1 - Reppert, Alexander von
A1 - Bargheer, Matias
T1 - Towards shaping picosecond strain pulses via magnetostrictive transducers
JF - Photoacoustics
N2 - Using time-resolved x-ray diffraction, we demonstrate the manipulation of the picosecond strain response of a metallic heterostructure consisting of a dysprosium (Dy) transducer and a niobium (Nb) detection layer by an external magnetic field. We utilize the first-order ferromagnetic–antiferromagnetic phase transition of the Dy layer, which provides an additional large contractive stress upon laser excitation compared to its zerofield response. This enhances the laser-induced contraction of the transducer and changes the shape of the picosecond strain pulses driven in Dy and detected within the buried Nb layer. Based on our experiment with rare-earth metals we discuss required properties for functional transducers, which may allow for novel field-control of the emitted picosecond strain pulses.
KW - picosecond ultrasonics
KW - magnetostriction
KW - ultrafast x-ray diffraction
KW - ultrafast photoacoustics
KW - nanoscale heat transfer
KW - negative thermal expansion
Y1 - 2023
U6 - https://doi.org/10.1016/j.pacs.2023.100463
SN - 2213-5979
VL - 30
PB - Elsevier
CY - Amsterdam
ER -
TY - GEN
A1 - Lemke, Tristan
T1 - Keine Reform für die Zukunft
T2 - Verfassungsblog : on matters constitutional
N2 - Am 1. Januar 2021 trat die jüngste Reform des Erneuerbare-Energien-Gesetzes (EEG) in Kraft. Sie führte mit der finanziellen Beteiligung der Gemeinden an den Erträgen der Windenergie klammheimlich eine verfassungswidrige Abgabe ein: Durch das Zusammenspiel des neuen § 36k EEG 2021 mit der altbekannten EEG-Umlage fließt eine bei den Strom-Endverbrauchern erhobene Abgabe in die kommunalen Haushalte. Das kann auf keine Gesetzgebungskompetenz gestützt werden. Darüber hinaus führt die Deckelung der EEG-Umlage in den Jahren 2021 und 2022 in Verbindung mit § 36k EEG 2021 dazu, dass in verfassungswidriger Weise Bundesmittel den Gemeinden zur freien Verfügung gestellt werden.
KW - Abgabe
KW - Umlage
Y1 - 2021
U6 - https://doi.org/10.17176/20210130-222740-0
SN - 2366-7044
PB - Max Steinbeis Verfassungsblog gGmbH
CY - Berlin
ER -
TY - JOUR
A1 - Heissel, Andreas
A1 - Sanchez, Alba
A1 - Pietrek, Anou F.
A1 - Bergau, Theresa
A1 - Stielow, Christiane
A1 - Rapp, Michael A.
A1 - Van der Kaap-Deeder, Jolene
T1 - Validating the German Short Basic Psychological Need Satisfaction and Frustration Scale in Individuals with Depression
JF - Healthcare
N2 - Satisfaction and frustration of the needs for autonomy, competence, and relatedness, as assessed with the 24-item Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS), have been found to be crucial indicators of individuals’ psychological health. To increase the usability of this scale within a clinical and health services research context, we aimed to validate a German short version (12 items) of this scale in individuals with depression including the examination of the relations from need frustration and need satisfaction to ill-being and quality of life (QOL). This cross-sectional study involved 344 adults diagnosed with depression (Mage (SD) = 47.5 years (11.1); 71.8% females). Confirmatory factor analyses indicated that the short version of the BPNSFS was not only reliable, but also fitted a six-factor structure (i.e., satisfaction/frustration X type of need). Subsequent structural equation modeling showed that need frustration related positively to indicators of ill-being and negatively to QOL. Surprisingly, need satisfaction did not predict differences in ill-being or QOL. The short form of the BPNSFS represents a practical instrument to measure need satisfaction and frustration in people with depression. Further, the results support recent evidence on the importance of especially need frustration in the prediction of psychopathology.
KW - basic psychological need frustration
KW - need satisfaction
KW - mental health
KW - ill-being
KW - depression
Y1 - 2023
U6 - https://doi.org/10.3390/healthcare11030412
SN - 2227-9032
VL - 11
IS - 3
PB - MDPI
CY - Basel
ER -
TY - JOUR
A1 - Wyckmans, Florent
A1 - Otto, A. Ross
A1 - Sebold, Miriam
A1 - Daw, Nathaniel
A1 - Bechara, Antoine
A1 - Saeremans, Mélanie
A1 - Kornreich, Charles
A1 - Chatard, Armand
A1 - Jaafari, Nemat
A1 - Noël, Xavier
T1 - Reduced model-based decision-making in gambling disorder
JF - Scientific reports
N2 - Compulsive behaviors (e.g., addiction) can be viewed as an aberrant decision process where inflexible reactions automatically evoked by stimuli (habit) take control over decision making to the detriment of a more flexible (goal-oriented) behavioral learning system. These behaviors are thought to arise from learning algorithms known as "model-based" and "model-free" reinforcement learning. Gambling disorder, a form of addiction without the confound of neurotoxic effects of drugs, showed impaired goal-directed control but the way in which problem gamblers (PG) orchestrate model-based and model-free strategies has not been evaluated. Forty-nine PG and 33 healthy participants (CP) completed a two-step sequential choice task for which model-based and model-free learning have distinct and identifiable trial-by-trial learning signatures. The influence of common psychopathological comorbidities on those two forms of learning were investigated. PG showed impaired model-based learning, particularly after unrewarded outcomes. In addition, PG exhibited faster reaction times than CP following unrewarded decisions. Troubled mood, higher impulsivity (i.e., positive and negative urgency) and current and chronic stress reported via questionnaires did not account for those results. These findings demonstrate specific reinforcement learning and decision-making deficits in behavioral addiction that advances our understanding and may be important dimensions for designing effective interventions.
Y1 - 2019
U6 - https://doi.org/10.1038/s41598-019-56161-z
SN - 2045-2322
VL - 9
PB - Nature Publ. Group
CY - London
ER -
TY - JOUR
A1 - Kaminski, Jakob A.
A1 - Schlagenhauf, Florian
A1 - Rapp, Michael A.
A1 - Awasthi, Swapnil
A1 - Ruggeri, Barbara
A1 - Deserno, Lorenz
A1 - Banaschewski, Tobias
A1 - Bokde, Arun L. W.
A1 - Bromberg, Uli
A1 - Büchel, Christian
A1 - Quinlan, Erin Burke
A1 - Desrivieres, Sylvane
A1 - Flor, Herta
A1 - Frouin, Vincent
A1 - Garavan, Hugh
A1 - Gowland, Penny
A1 - Ittermann, Bernd
A1 - Martinot, Jean-Luc
A1 - Martinot, Marie-Laure Paillere
A1 - Nees, Frauke
A1 - Orfanos, Dimitri Papadopoulos
A1 - Paus, Tomas
A1 - Poustka, Luise
A1 - Smolka, Michael N.
A1 - Fröhner, Juliane H.
A1 - Walter, Henrik
A1 - Whelan, Robert
A1 - Ripke, Stephan
A1 - Schumann, Gunter
A1 - Heinz, Andreas
T1 - Epigenetic variance in dopamine D2 receptor
BT - a marker of IQ malleability?
JF - Translational Psychiatry
N2 - Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.
Y1 - 2018
U6 - https://doi.org/10.1038/s41398-018-0222-7
SN - 2158-3188
VL - 8
PB - Nature Publ. Group
CY - New York
ER -
TY - JOUR
A1 - Herold, Fabian
A1 - Theobald, Paula
A1 - Gronwald, Thomas
A1 - Rapp, Michael A.
A1 - Müller, Notger Germar
T1 - Going digital – a commentary on the terminology used at the intersection of physical activity and digital health
JF - European review of aging and physical activity
N2 - In recent years digital technologies have become a major means for providing health-related services and this trend was strongly reinforced by the current Coronavirus disease 2019 (COVID-19) pandemic. As it is well-known that regular physical activity has positive effects on individual physical and mental health and thus is an important prerequisite for healthy aging, digital technologies are also increasingly used to promote unstructured and structured forms of physical activity. However, in the course of this development, several terms (e.g., Digital Health, Electronic Health, Mobile Health, Telehealth, Telemedicine, and Telerehabilitation) have been introduced to refer to the application of digital technologies to provide health-related services such as physical interventions. Unfortunately, the above-mentioned terms are often used in several different ways, but also relatively interchangeably. Given that ambiguous terminology is a major source of difficulty in scientific communication which can impede the progress of theoretical and empirical research, this article aims to make the reader aware of the subtle differences between the relevant terms which are applied at the intersection of physical activity and Digital Health and to provide state-of-art definitions for them.
KW - Digital Health
KW - Electronic Health
KW - Mobile Health
KW - Telehealth
KW - Telemedicine
KW - Physical activity
KW - Physical training
KW - Aging
Y1 - 2022
U6 - https://doi.org/10.1186/s11556-022-00296-y
SN - 1861-6909
VL - 19
PB - Springer
CY - Berlin ; Heidelberg
ER -
TY - JOUR
A1 - Heißel, Andreas
A1 - Bollmann, Julian
A1 - Kangas, Maria
A1 - Abdulla, K
A1 - Rapp, Michael A.
A1 - Sánchez Fernàndez, Alba Cristina
T1 - Validation of the German version of the work and social adjustment scale in a sample of depressed patients
JF - BMC health services research
N2 - Background
Depression is one of the key factors contributing to difficulties in one’s ability to work, and serves as one of the major reasons why employees apply for psychotherapy and receive insurance subsidization of treatments. Hence, an increasing and growing number of studies rely on workability assessment scales as their primary outcome measure. The Work and Social Assessment Scale (WSAS) has been documented as one of the most psychometrically reliable and valid tools especially developed to assess workability and social functioning in patients with mental health problems. Yet, the application of the WSAS in Germany has been limited due to the paucity of a valid questionnaire in the German language. The objective of the present study was to translate the WSAS, as a brief and easy administrable tool into German and test its psychometric properties in a sample of adults with depression.
Methods
Two hundred seventy-seven patients (M = 48.3 years, SD = 11.1) with mild to moderately severe depression were recruited. A multistep translation from English into the German language was performed and the factorial validity, criterion validity, convergent validity, discriminant validity, internal consistency, and floor and ceiling effects were examined.
Results
The confirmatory factor analysis results confirmed the one-factor structure of the WSAS. Significant correlations with the WHODAS 2–0 questionnaire, a measure of functionality, demonstrated good convergent validity. Significant correlations with depression and quality of life demonstrated good criterion validity. The WSAS also demonstrated strong internal consistency (α = .89), and the absence of floor and ceiling effects indicated good sensitivity of the instrument.
Conclusions
The results of the present study demonstrated that the German version of the WSAS has good psychometric properties comparable to other international versions of this scale. The findings recommend a global assessment of psychosocial functioning with the sum score of the WSAS.
KW - Workability
KW - Social functioning
KW - Depression
KW - Psychometric evaluation
KW - Translation
Y1 - 2021
U6 - https://doi.org/10.1186/s12913-021-06622-x
SN - 1472-6963
VL - 21
SP - 1
EP - 11
PB - BioMed Central
CY - London
ER -
TY - JOUR
A1 - Pérez Chaparro, Camilo Germán Alberto
A1 - Schuch, Felipe Barreto
A1 - Zech, Philipp
A1 - Kangas, Maria
A1 - Rapp, Michael A.
A1 - Heißel, Andreas
T1 - Recreational exercising and self-reported cardiometabolic diseases in German people living with HIV
BT - A cross-sectional study
JF - International journal of environmental research and public health : IJERPH / Molecular Diversity Preservation International
N2 - Exercise is known for its beneficial effects on preventing cardiometabolic diseases (CMDs) in the general population. People living with the human immunodeficiency virus (PLWH) are prone to sedentarism, thus raising their already elevated risk of developing CMDs in comparison to individuals without HIV. The aim of this cross-sectional study was to determine if exercise is associated with reduced risk of self-reported CMDs in a German HIV-positive sample (n = 446). Participants completed a self-report survey to assess exercise levels, date of HIV diagnosis, CD4 cell count, antiretroviral therapy, and CMDs. Participants were classified into exercising or sedentary conditions. Generalized linear models with Poisson regression were conducted to assess the prevalence ratio (PR) of PLWH reporting a CMD. Exercising PLWH were less likely to report a heart arrhythmia for every increase in exercise duration (PR: 0.20: 95% CI: 0.10–0.62, p < 0.01) and diabetes mellitus for every increase in exercise session per week (PR: 0.40: 95% CI: 0.10–1, p < 0.01). Exercise frequency and duration are associated with a decreased risk of reporting arrhythmia and diabetes mellitus in PLWH. Further studies are needed to elucidate the mechanisms underlying exercise as a protective factor for CMDs in PLWH.
KW - HIV
KW - exercise
KW - cardiovascular diseases
KW - metabolic disease
KW - sedentary
Y1 - 2021
U6 - https://doi.org/10.3390/ijerph182111579
SN - 1660-4601
VL - 18
IS - 21
SP - 1
EP - 10
PB - MDPI
CY - Basel, Schweiz
ER -
TY - JOUR
A1 - Gellert, Paul
A1 - Häusler, Andreas
A1 - Suhr, Ralf
A1 - Gholami, Maryam
A1 - Rapp, Michael A.
A1 - Kuhlmey, Adelheid
A1 - Nordheim, Johanna
T1 - Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia
JF - PLoS one
N2 - Purpose:
To test whether the negative relationship between perceived stress and quality of life (Hypothesis 1) can be buffered by perceived social support in patients with dementia as well as in caregivers individually (Hypothesis 2: actor effects) and across partners (Hypothesis 3: partner effects and actor-partner effects).
Method:
A total of 108 couples (N = 216 individuals) comprised of one individual with early-stage dementia and one caregiving partner were assessed at baseline and one month apart. Moderation effects were investigated by applying linear mixed models and actor-partner interdependence models.
Results:
Although the stress-quality of life association was more pronounced in caregivers (beta = -.63, p<.001) compared to patients (beta= -.31, p<.001), this association was equally moderated by social support in patients (beta = .14, p<.05) and in the caregivers (beta =.13, p<.05). From one partner to his or her counterpart, the partner buffering and actor-partner-buffering effect were not present.
Conclusion:
The stress-buffering effect has been replicated in individuals with dementia and caregivers but not across partners. Interventions to improve quality of life through perceived social support should not only focus on caregivers, but should incorporate both partners.
Y1 - 2018
U6 - https://doi.org/10.1371/journal.pone.0189849
SN - 1932-6203
VL - 13
IS - 1
PB - PLoS
CY - San Fransisco
ER -
TY - JOUR
A1 - Heinz, Andreas
A1 - Kiefer, Falk
A1 - Smolka, Michael N.
A1 - Endrass, Tanja
A1 - Beste, Christian
A1 - Beck, Anne
A1 - Liu, Shuyan
A1 - Genauck, Alexander
A1 - Romund, Lydia
A1 - Rapp, Michael A.
A1 - Tost, Heike
A1 - Spanagel, Rainer
T1 - Addiction research consortium: losing and regaining control over drug intake (ReCoDe) - from trajectories to mechanisms and interventions
JF - Addiction Biology
N2 - One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
KW - addiction
KW - alternative rewards
KW - animal and computational models
KW - cognitive-behavioral control
KW - craving and relapse
KW - habit formation
Y1 - 2019
VL - 25
IS - 2
PB - John Wiley & Sons, Inc.
CY - New Jersey
ER -
TY - JOUR
A1 - Schraplau, Anne
A1 - Block, Andrea
A1 - Häusler, Andreas
A1 - Wippert, Pia-Maria
A1 - Rapp, Michael A.
A1 - Völler, Heinz
A1 - Bonaventura, Klaus
A1 - Mayer, Frank
T1 - Mobile diagnostics and consultation for the prevention of the metabolic syndrome and its secondary diseases in Brandenburg—study protocol of a regional prospective cohort study
BT - the Mobile Brandenburg Cohort
JF - Pilot and Feasibility Studies
N2 - Background
The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a “Mobile Brandenburg Cohort” to reveal new causes and risk factors for MetS.
Methods
In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis.
Discussion
The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the “Mobile Brandenburg Cohort” create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions.
Trial registration
German Clinical Trials Register, DRKS00022764; registered 07 October 2020—retrospectively registered.
KW - Metabolic syndrome
KW - Mobile diagnostics
KW - Prevention
KW - Nutrition
KW - Physical activity
KW - Rural health
Y1 - 2021
U6 - https://doi.org/10.1186/s40814-021-00898-w
SN - 2055-5784
VL - 7
SP - 1
EP - 11
PB - BioMed Central (Springer Nature)
CY - London
ER -
TY - JOUR
A1 - Heissel, Andreas
A1 - Pietrek, Anou F.
A1 - Schwefel, Melanie
A1 - Abula, Kahar
A1 - Wilbertz, Gregor
A1 - Heinzel, Stephan
A1 - Rapp, Michael A.
T1 - STEP.De study
BT - a multicentre cluster-randomised effectiveness trial of exercise therapy for patients with depressive symptoms in healthcare services : study protocol
JF - BMJ open
N2 - Introduction Although exercise therapy has widely been shown to be an efficacious treatment modality for depression, evidence for its effectiveness and cost efficiency is lacking. The Sport/Exercise Therapy for Depression study is a multicentre cluster-randomised effectiveness trial that aims to compare the effectiveness and cost efficiency of exercise therapy and psychotherapy as antidepressant treatment.
Methods and analysis 480 patients (aged 18-65) with an International Classification of Diseases diagnosis associated with depressive symptoms are recruited. Up to 30 clusters (psychotherapists) are randomly assigned to allocate patients to either an exercise or a psychotherapy treatment as usual in a 2: 1 ratio. The primary outcome (depressive symptoms) and the secondary outcomes (work and social adjustment, quality of life) will be assessed at six measurement time points (t0: baseline, t1: 8 weeks after treatment initiation, t2: 16 weeks after treatment initiation, t3/ 4/5: 2, 6, 12 months after treatment). Linear regression analyses will be used for the primary endpoint data analysis. For the secondary endpoints, mixed linear and logistic regression models with fixed and random factors will be added. For the cost efficiency analysis, expenditures in the 12 months before and after the intervention and the outcome difference will be compared between groups in a multilevel model. Recruitment start date was 1 July 2018 and the planned recruitment end date is 31 December 2020.
Ethics and dissemination The study protocol was approved by the ethics committee of the University of Potsdam (No. 17/2018) and the Freie Universitat Berlin (No. 206/2018) and registered in the ISRCTN registry. Informed written consent will be obtained from all participants. The study will be reported in accordance with the Consolidated Standards of Reporting Trials and the Recommendations for Interventional Trials statements. The results will be published in peer-reviewed academic journals and disseminated to the public.
Y1 - 2020
U6 - https://doi.org/10.1136/bmjopen-2019-036287
SN - 2044-6055
VL - 10
IS - 4
PB - BMJ Publishing Group
CY - London
ER -
TY - JOUR
A1 - Schulze, Susanne
A1 - Merz, Sibille
A1 - Thier, Anne
A1 - Tallarek, Marie
A1 - König, Franziska
A1 - Uhlenbrock, Greta
A1 - Nübling, Matthias
A1 - Lincke, Hans-Joachim
A1 - Rapp, Michael A.
A1 - Spallek, Jacob
A1 - Holmberg, Christine
T1 - Psychosocial burden in nurses working in nursing homes during the Covid-19 pandemic
BT - a cross-sectional study with quantitative and qualitative data
JF - BMC health services research
N2 - Background The Covid-19 pandemic led to increased work-related strain and psychosocial burden in nurses worldwide, resulting in high prevalences of mental health problems. Nurses in long-term care facilities seem to be especially affected by the pandemic. Nevertheless, there are few findings indicating possible positive changes for health care workers. Therefore, we investigated which psychosocial burdens and potential positive aspects nurses working in long-term care facilities experience during the Covid-19 pandemic. Methods We conducted a mixed-methods study among nurses and nursing assistants working in nursing homes in Germany. The survey contained the third German version of the Copenhagen Psychosocial Questionnaire (COPSOQ III). Using Welch's t-tests, we compared the COPSOQ results of our sample against a pre-pandemic reference group of geriatric nurses from Germany. Additionally, we conducted semi-structured interviews with geriatric nurses with a special focus on psychosocial stress, to reach a deeper understanding of their experiences on work-related changes and burdens during the pandemic. Data were analysed using thematic coding (Braun and Clarke). Results Our survey sample (n = 177) differed significantly from the pre-pandemic reference group in 14 out of 31 COPSOQ scales. Almost all of these differences indicated negative changes. Our sample scored significantly worse regarding the scales 'quantitative demands', 'hiding emotions', 'work-privacy conflicts', 'role conflicts', 'quality of leadership', 'support at work', 'recognition', 'physical demands', 'intention to leave profession', 'burnout', 'presenteeism' and 'inability to relax'. The interviews (n = 15) revealed six main themes related to nurses' psychosocial stress: 'overall working conditions', 'concern for residents', 'management of relatives', 'inability to provide terminal care', 'tensions between being infected and infecting others' and 'technicisation of care'. 'Enhanced community cohesion' (interviews), 'meaning of work' and 'quantity of social relations' (COPSOQ III) were identified as positive effects of the pandemic. Conclusions Results clearly illustrate an aggravation of geriatric nurses' situation and psychosocial burden and only few positive changes due to the Covid-19 pandemic. Pre-existing hardships seem to have further deteriorated and new stressors added to nurses' strain. The perceived erosion of care, due to an overemphasis of the technical in relation to the social and emotional dimensions of care, seems to be especially burdensome to geriatric nurses.
KW - COPSOQ
KW - Nurses
KW - Nursing home
KW - Psychosocial burden
KW - Mixed-methods study
KW - Covid-19
Y1 - 2022
U6 - https://doi.org/10.1186/s12913-022-08333-3
SN - 1472-6963
VL - 22
IS - 1
PB - BMC
CY - London
ER -
TY - JOUR
A1 - Ye, Fangyuan
A1 - Zhang, Shuo
A1 - Warby, Jonathan
A1 - Wu, Jiawei
A1 - Gutierrez-Partida, Emilio
A1 - Lang, Felix
A1 - Shah, Sahil
A1 - Saglamkaya, Elifnaz
A1 - Sun, Bowen
A1 - Zu, Fengshuo
A1 - Shoaee, Safa
A1 - Wang, Haifeng
A1 - Stiller, Burkhard
A1 - Neher, Dieter
A1 - Zhu, Wei-Hong
A1 - Stolterfoht, Martin
A1 - Wu, Yongzhen
T1 - Overcoming C-60-induced interfacial recombination in inverted perovskite solar cells by electron-transporting carborane
JF - Nature Communications
N2 - Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C-60 interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C-60 interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23% with a low non-radiative voltage loss of 110mV, and retain >97% of the initial efficiency after 400h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells. Effective transport layers are essential to suppress non-radiative recombination losses. Here, the authors introduce phenylamino-functionalized ortho-carborane as an interfacial layer, and realise inverted perovskite solar cells with efficiency of over 23% and operational stability of T97=400h.
Y1 - 2022
U6 - https://doi.org/10.1038/s41467-022-34203-x
SN - 2041-1723
VL - 13
IS - 1
PB - Nature Publishing Group
CY - London
ER -