TY - JOUR A1 - Wachs, Sebastian A1 - Wright, Michelle F. A1 - Sittichai, Ruthaychonnee A1 - Singh, Ritu A1 - Biswal, Ramakrishna A1 - Kim, Eun-mee A1 - Yang, Soeun A1 - Gámez-Guadix, Manuel A1 - Almendros, Carmen A1 - Flora, Katerina A1 - Daskalou, Vassiliki A1 - Maziridou, Evdoxia T1 - Associations between witnessing and perpetrating online hate in eight countries BT - the buffering effects of problem-focused coping JF - International Journal of Environmental Research and Public Health N2 - Online hate is a topic that has received considerable interest lately, as online hate represents a risk to self-determination and peaceful coexistence in societies around the globe. However, not much is known about the explanations for adolescents posting or forwarding hateful online material or how adolescents cope with this newly emerging online risk. Thus, we sought to better understand the relationship between a bystander to and perpetrator of online hate, and the moderating effects of problem-focused coping strategies (e.g., assertive, technical coping) within this relationship. Self-report questionnaires on witnessing and committing online hate and assertive and technical coping were completed by 6829 adolescents between 12 and 18 years of age from eight countries. The results showed that increases in witnessing online hate were positively related to being a perpetrator of online hate. Assertive and technical coping strategies were negatively related with perpetrating online hate. Bystanders of online hate reported fewer instances of perpetrating online hate when they reported higher levels of assertive and technical coping strategies, and more frequent instances of perpetrating online hate when they reported lower levels of assertive and technical coping strategies. In conclusion, our findings suggest that, if effective, prevention and intervention programs that target online hate should consider educating young people about problem-focused coping strategies, self-assertiveness, and media skills. Implications for future research are discussed. KW - online hate KW - hate speech KW - bystander KW - perpetrator KW - coping strategies KW - cyber aggression Y1 - 2019 U6 - https://doi.org/10.3390/ijerph16203992 SN - 1660-4601 VL - 16 IS - 20 PB - MDPI CY - Basel ER - TY - JOUR A1 - Granacher, Urs A1 - Nobari, Hadi A1 - Ruivo Alves, Ana A1 - Clemente, Filipe Manuel A1 - Pérez-Gómez, Jorge A1 - Clark, Cain Craig Truman A1 - Zouhal, Hassane T1 - Associations Between Variations in Accumulated Workload and Physiological Variables in Young Male Soccer Players Over the Course of a Season JF - Frontiers in physiology N2 - This study sought to analyze the relationship between in-season training workload with changes in aerobic power (VO2max), maximum and resting heart rate (HRmax and HRrest), linear sprint medium (LSM), and short test (LSS), in soccer players younger than 16 years (under-16 soccer players). We additionally aimed to explain changes in fitness levels during the in-season through regression models, considering accumulated load, baseline levels, and peak height velocity (PHV) as predictors. Twenty-three male sub-elite soccer players aged 15.5 ± 0.2 years (PHV: 13.6 ± 0.4 years; body height: 172.7 ± 4.2 cm; body mass: 61.3 ± 5.6 kg; body fat: 13.7% ± 3.9%; VO2max: 48.4 ± 2.6 mL⋅kg–1⋅min–1), were tested three times across the season (i.e., early-season (EaS), mid-season (MiS), and end-season (EnS) for VO2max, HRmax, LSM, and LSS. Aerobic and speed variables gradually improved over the season and had a strong association with PHV. Moreover, the HRmax demonstrated improvements from EaS to EnS; however, this was more evident in the intermediate period (from EaS to MiS) and had a strong association with VO2max. Regression analysis showed significant predictions for VO2max [F(2, 20) = 8.18, p ≤ 0.001] with an R2 of 0.45. In conclusion, the meaningful variation of youth players’ fitness levels can be observed across the season, and such changes can be partially explained by the load imposed. KW - internal load KW - heart rate KW - linear sprint KW - aerobic power KW - football Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.638180 SN - 1664-042X VL - 12 SP - 1 EP - 12 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Wick, Kristin A1 - Kriemler, Susi A1 - Granacher, Urs T1 - Associations between measures of physical fitness and cognitive performance in preschool children JF - BMC sports science, medicine & rehabilitation N2 - Background: Given that recent studies report negative secular declines in physical fitness, associations between fitness and cognition in childhood are strongly discussed. The preschool age is characterized by high neuroplasticity which effects motor skill learning, physical fitness, and cognitive development. The aim of this study was to assess the relation of physical fitness and attention (including its individual dimensions (quantitative, qualitative)) as one domain of cognitive performance in preschool children. We hypothesized that fitness components which need precise coordination compared to simple fitness components are stronger related to attention. Methods: Physical fitness components like static balance (i.e., single-leg stance), muscle strength (i.e., handgrip strength), muscle power (i.e., standing long jump), and coordination (i.e., hopping on one leg) were assessed in 61 healthy children (mean age 4.5 +/- 0.6 years; girls n = 30). Attention was measured with the "Konzentrations-Handlungsverfahren fur Vorschulkinder" [concentration-action procedure for preschoolers]). Analyses were adjusted for age, body height, and body mass. Results: Results from single linear regression analysis revealed a significant (p < 0.05) association between physical fitness (composite score) and attention (composite score) (standardized ss = 0.40), showing a small to medium effect (F-2 = 0.14). Further, coordination had a significant relation with the composite score and the quantitative dimension of attention (standardized ss = 0.35; p < 0.01; standardized ss = - 0.33; p < 0.05). Coordination explained about 11% (composite score) and 9% (quantitative dimension) of the variance in the stepwise multiple regression model. Conclusion: The results indicate that performance in physical fitness, particularly coordination, is related to attention in preschool children. Thus, high performance in complex fitness components (i.e., hopping on one leg) tends to predict attention in preschool children. Further longitudinal studies should focus on the effectiveness of physical activity programs implementing coordination and complex exercises at preschool age to examine cause-effect relationships between physical fitness and attention precisely. KW - Motor skills KW - Cognitive skills KW - Attention KW - Kindergarten Y1 - 2022 U6 - https://doi.org/10.1186/s13102-022-00470-w SN - 2052-1847 VL - 14 IS - 1 PB - BMC CY - London ER - TY - JOUR A1 - Wachs, Sebastian A1 - Machimbarrena, Juan Manuel A1 - Wright, Michelle F. A1 - Gámez-Guadix, Manuel A1 - Yang, Soeun A1 - Sittichai, Ruthaychonnee A1 - Singh, Ritu A1 - Biswal, Ramakrishna A1 - Flora, Katerina A1 - Daskalou, Vassiliki A1 - Maziridou, Evdoxia A1 - Sung Hong, Jun A1 - Krause, Norman T1 - Associations between coping strategies and cyberhate involvement BT - evidence from adolescents across three world regions JF - International journal of environmental research and public health N2 - Cyberhate represents a risk to adolescents’ development and peaceful coexistence in democratic societies. Yet, not much is known about the relationship between adolescents’ ability to cope with cyberhate and their cyberhate involvement. To fill current gaps in the literature and inform the development of media education programs, the present study investigated various coping strategies in a hypothetical cyberhate scenario as correlates for being cyberhate victims, perpetrators, and both victim–perpetrators. The sample consisted of 6829 adolescents aged 12–18 years old (Mage = 14.93, SD = 1.64; girls: 50.4%, boys: 48.9%, and 0.7% did not indicate their gender) from Asia, Europe, and North America. Results showed that adolescents who endorsed distal advice or endorsed technical coping showed a lower likelihood to be victims, perpetrators, or victim–perpetrators. In contrast, if adolescents felt helpless or endorsed retaliation to cope with cyberhate, they showed higher odds of being involved in cyberhate as victims, perpetrators, or victim–perpetrators. Finally, adolescents who endorsed close support as a coping strategy showed a lower likelihood to be victim–perpetrators, and adolescents who endorsed assertive coping showed higher odds of being victims. In conclusion, the results confirm the importance of addressing adolescents’ ability to deal with cyberhate to develop more tailored prevention approaches. More specifically, such initiatives should focus on adolescents who feel helpless or feel inclined to retaliate. In addition, adolescents should be educated to practice distal advice and technical coping when experiencing cyberhate. Implications for the design and instruction of evidence-based cyberhate prevention (e.g., online educational games, virtual learning environments) will be discussed. KW - cyberhate KW - hate speech KW - coping strategies KW - cross-national KW - counter-speech Y1 - 2022 U6 - https://doi.org/10.3390/ijerph19116749 SN - 1660-4601 VL - 19 SP - 1 EP - 14 PB - MDPI CY - Basel, Schweiz ET - 11 ER - TY - JOUR A1 - Kwanbunjan, Karunee A1 - Panprathip, Pornpimol A1 - Phosat, Chanchira A1 - Chumpathat, Noppanath A1 - Wechjakwen, Naruemon A1 - Puduang, Somchai A1 - Auyyuenyong, Ratchada A1 - Henkel, Ina A1 - Schweigert, Florian J. T1 - Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk JF - BMC Endocrine Disorders N2 - Background: Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate the relationship between RBP4, TTR, triglyceride (TG) and type 2 diabetes risk in rural Thailand. Results: RBP4 and TTR levels, as well as homeostatic model assessment of insulin resistance (HOMA-IR) values, were significantly elevated among subjects with high triglyceride levels (p < 0.01, p < 0.05, p < 0.05, respectively). Triglyceride levels correlated with RBP4 (r = 0.34, p < 0.001) and TTR (r= 0.26, p < 0.01) levels, as well as HOMA-IR values (r= 0.16, p < 0.05). After adjustment for age and gender, the risk of hypertriglyceridemia was 3.7 times greater (95% Cl =1.42 -9.73, p = 0.008) in the highest RBP4 tertile as compared to the lowest tertile. Similarly, the highest TTR and HOMA-IR tertiles had greater risk of hypertriglyceridemia at 3.5 (95% Cl = 1.30-9.20, p = 0.01) and 3.6 (95% CI = 1.33- 9.58, p = 0.01) times higher than the respective lowest tertiles. The correlation between TTR and blood glucose was statistically significant (r 0.18, p < 0.05), but not found this relationship in RBP4. Conclusions: The associations of RBP4 and TTR with hypertriglyceridemia and insulin resistance may have important implications for the risk of heart disease and stroke. KW - RBP4 KW - TTR KW - HOMA-IR KW - Hypertriglyceridemia KW - Type 2 diabetes Y1 - 2018 U6 - https://doi.org/10.1186/s12902-018-0254-2 SN - 1472-6823 VL - 18 PB - BMC CY - London ER - TY - JOUR A1 - Osei, Francis A1 - Block, Andrea A1 - Wippert, Pia-Maria T1 - Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review JF - Frontiers in Endocrinology N2 - Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS. KW - allostatic load KW - cortisol KW - dehydroepiandrosterone sulfate KW - epinephrine KW - norepinephrine KW - metabolic syndrome KW - primary marker Y1 - 2022 U6 - https://doi.org/10.3389/fendo.2022.946740 SN - 1664-2392 VL - 13 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Eichelmann, Fabian A1 - Schulze, Matthias Bernd A1 - Wittenbecher, Clemens A1 - Menzel, Juliane A1 - Weikert, Cornelia A1 - di Giuseppe, Romina A1 - Biemann, Ronald A1 - Isermann, Berend A1 - Fritsche, Andreas A1 - Boeing, Heiner A1 - Aleksandrova, Krasimira T1 - Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer JF - JAMA network open N2 - IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis. Y1 - 2019 U6 - https://doi.org/10.1001/jamanetworkopen.2019.0896 SN - 2574-3805 VL - 2 IS - 3 PB - American Veterinary Medical Association CY - Chicago ER - TY - JOUR A1 - Arazi, Hamid A1 - Asadi, Abbas A1 - Khalkhali, Farhood A1 - Boullosa, Daniel A1 - Hackney, Anthony C. A1 - Granacher, Urs A1 - Zouhal, Hassane T1 - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players BT - A Preliminary Study JF - Frontiers in Physiology N2 - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r 2) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season. KW - training load KW - rate of perceived exertion KW - rolling averages KW - weighted moving averages KW - football Y1 - 2020 U6 - https://doi.org/10.3389/fphys.2020.00995 SN - 1664-042X VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Sariati, Dorsaf A1 - Zouhal, Hassane A1 - Hammami, Raouf A1 - Clark, Cain Craig Truman A1 - Nebigh, Ammar A1 - Chtara, Moktar A1 - Hackney, Anthony C. A1 - Souissi, Nizar A1 - Granacher, Urs A1 - Ben Ounis, Omar T1 - Association Between Mental Imagery and Change of Direction Performance in Young Elite Soccer Players of Different Maturity Status JF - Frontiers in Psychology N2 - Previous studies have not considered the potential influence of maturity status on the relationship between mental imagery and change of direction (CoD) speed in youth soccer. Accordingly, this cross-sectional study examined the association between mental imagery and CoD performance in young elite soccer players of different maturity status. Forty young male soccer players, aged 10-17 years, were assigned into two groups according to their predicted age at peak height velocity (PHV) (Pre-PHV; n = 20 and Post-PHV; n = 20). Participants were evaluated on soccer-specific tests of CoD with (CoDBall-15m) and without (CoD-15m) the ball. Participants completed the movement imagery questionnaire (MIQ) with the three- dimensional structure, internal visual imagery (IVI), external visual imagery (EVI), as well as kinesthetic imagery (KI). The Post-PHV players achieved significantly better results than Pre-PHV in EVI (ES = 1.58, large; p < 0.001), CoD-15m (ES = 2.09, very large; p < 0.001) and CoDBall-15m (ES = 1.60, large; p < 0.001). Correlations were significantly different between maturity groups, where, for the pre-PHV group, a negative very large correlation was observed between CoDBall-15m and KI (r = –0.73, p = 0.001). For the post-PHV group, large negative correlations were observed between CoD-15m and IVI (r = –0.55, p = 0.011), EVI (r = –062, p = 0.003), and KI (r = –0.52, p = 0.020). A large negative correlation of CoDBall-15m with EVI (r = –0.55, p = 0.012) and very large correlation with KI (r = –0.79, p = 0.001) were also observed. This study provides evidence of the theoretical and practical use for the CoD tasks stimulus with imagery. We recommend that sport psychology specialists, coaches, and athletes integrated imagery for CoD tasks in pre-pubertal soccer players to further improve CoD related performance. KW - mental imagery KW - football KW - maturation KW - speed KW - adolescents Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.665508 SN - 1664-1078 VL - 12 SP - 1 EP - 9 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Dech, Silas A1 - Bittmann, Frank A1 - Schaefer, Laura T1 - Assessment of the adaptive force of Elbow extensors in healthy subjects quantified by a novel pneumatically driven measurement system with considerations of its quality criteria JF - Diagnostics : open access journal N2 - Adaptive Force (AF) reflects the capability of the neuromuscular system to adapt adequately to external forces with the intention of maintaining a position or motion. One specific approach to assessing AF is to measure force and limb position during a pneumatically applied increasing external force. Through this method, the highest (AFmax), the maximal isometric (AFisomax) and the maximal eccentric Adaptive Force (AFeccmax) can be determined. The main question of the study was whether the AFisomax is a specific and independent parameter of muscle function compared to other maximal forces. In 13 healthy subjects (9 male and 4 female), the maximal voluntary isometric contraction (pre- and post-MVIC), the three AF parameters and the MVIC with a prior concentric contraction (MVICpri-con) of the elbow extensors were measured 4 times on two days. Arithmetic mean (M) and maximal (Max) torques of all force types were analyzed. Regarding the reliability of the AF parameters between days, the mean changes were 0.31–1.98 Nm (0.61%–5.47%, p = 0.175–0.552), the standard errors of measurements (SEM) were 1.29–5.68 Nm (2.53%–15.70%) and the ICCs(3,1) = 0.896–0.996. M and Max of AFisomax, AFmax and pre-MVIC correlated highly (r = 0.85–0.98). The M and Max of AFisomax were significantly lower (6.12–14.93 Nm; p ≤ 0.001–0.009) and more variable between trials (coefficient of variation (CVs) ≥ 21.95%) compared to those of pre-MVIC and AFmax (CVs ≤ 5.4%). The results suggest the novel measuring procedure is suitable to reliably quantify the AF, whereby the presented measurement errors should be taken into consideration. The AFisomax seems to reflect its own strength capacity and should be detected separately. It is suggested its normalization to the MVIC or AFmax could serve as an indicator of a neuromuscular function. KW - adaptive force KW - sensorimotor control KW - isometric muscle action KW - eccentric muscle action KW - maximal voluntary contraction KW - adaptive holding capacity KW - reliability KW - validity KW - neuromuscular functionality Y1 - 2021 U6 - https://doi.org/10.3390/diagnostics11060923 SN - 2075-4418 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - König, Johanna A1 - Block, Andrea A1 - Becker, Mathias A1 - Fenske, Kristin A1 - Hertel, Johannes A1 - Van der Auwera, Sandra A1 - Zymara, Kathleen A1 - Voelzke, Henry A1 - Freyberger, Harald Jürgen A1 - Grabe, Hans Joergen T1 - Assessment of subjective emotional valence and long-lasting impact of life events BT - development and psychometrics of the Stralsund Life Event List (SEL) JF - BMC Psychiatry N2 - Background: Life events (LEs) are associated with future physical and mental health. They are crucial for understanding the pathways to mental disorders as well as the interactions with biological parameters. However, deeper insight is needed into the complex interplay between the type of LE, its subjective evaluation and accompanying factors such as social support. The "Stralsund Life Event List" (SEL) was developed to facilitate this research. Methods: The SEL is a standardized interview that assesses the time of occurrence and frequency of 81 LEs, their subjective emotional valence, the perceived social support during the LE experience and the impact of past LEs on present life. Data from 2265 subjects from the general population-based cohort study "Study of Health in Pomerania" (SHIP) were analysed. Based on the mean emotional valence ratings of the whole sample, LEs were categorized as "positive" or "negative". For verification, the SEL was related to lifetime major depressive disorder (MDD; Munich Composite International Diagnostic Interview), childhood trauma (Childhood Trauma Questionnaire), resilience (Resilience Scale) and subjective health (SF-12 Health Survey). Conclusions: The SEL is a valid instrument that enables the analysis of the number and frequency of LEs, their emotional valence, perceived social support and current impact on life on a global score and on an individual item level. Thus, we can recommend its use in research settings that require the assessment and analysis of the relationship between the occurrence and subjective evaluation of LEs as well as the complex balance between distressing and stabilizing life experiences. KW - Positive life events KW - Negative life events KW - General population KW - Emotional valence KW - Depressive disorder Y1 - 2018 U6 - https://doi.org/10.1186/s12888-018-1649-3 SN - 1471-244X VL - 18 PB - BioMed Central CY - London ER - TY - JOUR A1 - Hahn, Daniela A1 - Weck, Florian A1 - Witthöft, Michael A1 - Kühne, Franziska T1 - Assessment of counseling self-efficacy BT - validation of the German Counselor Activity self-efficacy scales-revised JF - Frontiers in psychology / Frontiers Research Foundation N2 - Background: Many authors regard counseling self-efficacy (CSE) as important in therapist development and training. The purpose of this study was to examine the factor structure, reliability, and validity of the German version of the Counselor Activity Self-Efficacy Scales-Revised (CASES-R). Method: The sample consisted of 670 German psychotherapy trainees, who completed an online survey. We examined the factor structure by applying exploratory and confirmatory factor analysis to the instrument as a whole. Results: A bifactor-exploratory structural equation modeling model with one general and five specific factors provided the best fit to the data. Omega hierarchical coefficients indicated optimal reliability for the general factor, acceptable reliability for the Action Skills-Revised (AS-R) factor, and insufficient estimates for the remaining factors. The CASES-R scales yielded significant correlations with related measures, but also with therapeutic orientations. Conclusion: We found support for the reliability and validity of the German CASES-R. However, the subdomains (except AS-R) should be interpreted with caution, and we do not recommend the CASES-R for comparisons between psychotherapeutic orientations. KW - counselor activity self-efficacy scales KW - counseling self-efficacy KW - psychotherapy training KW - assessment KW - factor structure KW - validation Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.780088 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Ben Nsir, Siwar A1 - Jomaa, Seifeddine A1 - Yildirim, Umit A1 - Zhou, Xiangqian A1 - D'Oria, Marco A1 - Rode, Michael A1 - Khlifi, Slaheddine T1 - Assessment of climate change impact on discharge of the lakhmass catchment (Northwest Tunisia) JF - Water N2 - The Mediterranean region is increasingly recognized as a climate change hotspot but is highly underrepresented in hydrological climate change studies. This study aims to investigate the climate change effects on the hydrology of Lakhmass catchment in Tunisia. Lakhmass catchment is a part of the Medium Valley of Medjerda in northwestern Tunisia that drains an area of 126 km(2). First, the Hydrologiska Byrans Vattenbalansavdelning light (HBV-light) model was calibrated and validated successfully at a daily time step to simulate discharge during the 1981-1986 period. The Nash Sutcliffe Efficiency and Percent bias (NSE, PBIAS) were (0.80, +2.0%) and (0.53, -9.5%) for calibration (September 1982-August 1984) and validation (September 1984-August 1986) periods, respectively. Second, HBV-light model was considered as a predictive tool to simulate discharge in a baseline period (1981-2009) and future projections using data (precipitation and temperature) from thirteen combinations of General Circulation Models (GCMs) and Regional Climatic Models (RCMs). We used two trajectories of Representative Concentration Pathways, RCP4.5 and RCP8.5, suggested by the Intergovernmental Panel on Climate Change (IPCC). Each RCP is divided into three projection periods: near-term (2010-2039), mid-term (2040-2069) and long-term (2070-2099). For both scenarios, a decrease in precipitation and discharge will be expected with an increase in air temperature and a reduction in precipitation with almost 5% for every +1 degrees C of global warming. By long-term (2070-2099) projection period, results suggested an increase in temperature with about 2.7 degrees C and 4 degrees C, and a decrease in precipitation of approximately 7.5% and 15% under RCP4.5 and RCP8.5, respectively. This will likely result in a reduction of discharge of 12.5% and 36.6% under RCP4.5 and RCP8.5, respectively. This situation calls for early climate change adaptation measures under a participatory approach, including multiple stakeholders and water users. KW - hydrological modeling KW - HBV-light model KW - Mediterranean KW - discharge KW - climate change KW - RCP4,5 and 8,5 Y1 - 2022 U6 - https://doi.org/10.3390/w14142242 SN - 2073-4441 VL - 14 IS - 14 PB - MDPI CY - Basel ER - TY - JOUR A1 - Henschke, Jakob A1 - Kaplick, Hannes A1 - Wochatz, Monique A1 - Engel, Tilman T1 - Assessing the validity of inertial measurement units for shoulder kinematics using a commercial sensor-software system BT - a validation study JF - Health science reports N2 - Background and Aims Wearable inertial sensors may offer additional kinematic parameters of the shoulder compared to traditional instruments such as goniometers when elaborate and time-consuming data processing procedures are undertaken. However, in clinical practice simple-real time motion analysis is required to improve clinical reasoning. Therefore, the aim was to assess the criterion validity between a portable "off-the-shelf" sensor-software system (IMU) and optical motion (Mocap) for measuring kinematic parameters during active shoulder movements. Methods 24 healthy participants (9 female, 15 male, age 29 +/- 4 years, height 177 +/- 11 cm, weight 73 +/- 14 kg) were included. Range of motion (ROM), total range of motion (TROM), peak and mean angular velocity of both systems were assessed during simple (abduction/adduction, horizontal flexion/horizontal extension, vertical flexion/extension, and external/internal rotation) and complex shoulder movements. Criterion validity was determined using intraclass-correlation coefficients (ICC), root mean square error (RMSE) and Bland and Altmann analysis (bias; upper and lower limits of agreement). Results ROM and TROM analysis revealed inconsistent validity during simple (ICC: 0.040-0.733, RMSE: 9.7 degrees-20.3 degrees, bias: 1.2 degrees-50.7 degrees) and insufficient agreement during complex shoulder movements (ICC: 0.104-0.453, RMSE: 10.1 degrees-23.3 degrees, bias: 1.0 degrees-55.9 degrees). Peak angular velocity (ICC: 0.202-0.865, RMSE: 14.6 degrees/s-26.7 degrees/s, bias: 10.2 degrees/s-29.9 degrees/s) and mean angular velocity (ICC: 0.019-0.786, RMSE:6.1 degrees/s-34.2 degrees/s, bias: 1.6 degrees/s-27.8 degrees/s) were inconsistent. Conclusions The "off-the-shelf" sensor-software system showed overall insufficient agreement with the gold standard. Further development of commercial IMU-software-solutions may increase measurement accuracy and permit their integration into everyday clinical practice. KW - diagnostic techniques and procedures KW - kinematics KW - shoulder joint KW - validation study KW - wearable devices Y1 - 2022 U6 - https://doi.org/10.1002/hsr2.772 SN - 2398-8835 VL - 5 IS - 5 SP - 1 EP - 11 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Fehr, Jana A1 - Piccininni, Marco A1 - Kurth, Tobias A1 - Konigorski, Stefan T1 - Assessing the transportability of clinical prediction models for cognitive impairment using causal models JF - BMC medical research methodology N2 - Background Machine learning models promise to support diagnostic predictions, but may not perform well in new settings. Selecting the best model for a new setting without available data is challenging. We aimed to investigate the transportability by calibration and discrimination of prediction models for cognitive impairment in simulated external settings with different distributions of demographic and clinical characteristics. Methods We mapped and quantified relationships between variables associated with cognitive impairment using causal graphs, structural equation models, and data from the ADNI study. These estimates were then used to generate datasets and evaluate prediction models with different sets of predictors. We measured transportability to external settings under guided interventions on age, APOE & epsilon;4, and tau-protein, using performance differences between internal and external settings measured by calibration metrics and area under the receiver operating curve (AUC). Results Calibration differences indicated that models predicting with causes of the outcome were more transportable than those predicting with consequences. AUC differences indicated inconsistent trends of transportability between the different external settings. Models predicting with consequences tended to show higher AUC in the external settings compared to internal settings, while models predicting with parents or all variables showed similar AUC. Conclusions We demonstrated with a practical prediction task example that predicting with causes of the outcome results in better transportability compared to anti-causal predictions when considering calibration differences. We conclude that calibration performance is crucial when assessing model transportability to external settings. KW - Alzheimer's Disease KW - Clinical risk prediction KW - DAG KW - Causality; KW - Transportability Y1 - 2023 U6 - https://doi.org/10.1186/s12874-023-02003-6 SN - 1471-2288 VL - 23 IS - 1 PB - BMC CY - London ER - TY - JOUR A1 - Pawlak, Julia A1 - Noetzel, Dominique Christian A1 - Drago, Claudia A1 - Weithoff, Guntram T1 - Assessing the toxicity of polystyrene beads and silica particles on the microconsumer Brachionus calyciflorus at different timescales JF - Frontiers in Environmental Science N2 - Environmental pollution by microplastics has become a severe problem in terrestrial and aquatic ecosystems and, according to actual prognoses, problems will further increase in the future. Therefore, assessing and quantifying the risk for the biota is crucial. Standardized short-term toxicological procedures as well as methods quantifying potential toxic effects over the whole life span of an animal are required. We studied the effect of the microplastic polystyrene on the survival and reproduction of a common freshwater invertebrate, the rotifer Brachionus calyciflorus, at different timescales. We used pristine polystyrene spheres of 1, 3, and 6 µm diameter and fed them to the animals together with food algae in different ratios ranging from 0 to 50% nonfood particles. As a particle control, we used silica to distinguish between a pure particle effect and a plastic effect. After 24 h, no toxic effect was found, neither with polystyrene nor with silica. After 96 h, a toxic effect was detectable for both particle types. The size of the particles played a negligible role. Studying the long-term effect by using life table experiments, we found a reduced reproduction when the animals were fed with 3 µm spheres together with similar-sized food algae. We conclude that the fitness reduction is mainly driven by the dilution of food by the nonfood particles rather than by a direct toxic effect. KW - microplastics KW - rotifer KW - freshwater KW - natural particle KW - toxicity KW - environmental pollution Y1 - 2022 U6 - https://doi.org/10.3389/fenvs.2022.955425 SN - 2296-665X SP - 1 EP - 11 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Jing, Miao A1 - Kumar, Rohini A1 - Heße, Falk A1 - Thober, Stephan A1 - Rakovec, Oldrich A1 - Samaniego, Luis A1 - Attinger, Sabine T1 - Assessing the response of groundwater quantity and travel time distribution to 1.5, 2, and 3 °C global warming in a mesoscale central German basin JF - Hydrology and Earth System Sciences N2 - Groundwater is the biggest single source of high-quality freshwater worldwide, which is also continuously threatened by the changing climate. In this paper, we investigate the response of the regional groundwater system to climate change under three global warming levels (1.5, 2, and 3 ∘C) in a central German basin (Nägelstedt). This investigation is conducted by deploying an integrated modeling workflow that consists of a mesoscale hydrologic model (mHM) and a fully distributed groundwater model, OpenGeoSys (OGS). mHM is forced with climate simulations of five general circulation models under three representative concentration pathways. The diffuse recharges estimated by mHM are used as boundary forcings to the OGS groundwater model to compute changes in groundwater levels and travel time distributions. Simulation results indicate that groundwater recharges and levels are expected to increase slightly under future climate scenarios. Meanwhile, the mean travel time is expected to decrease compared to the historical average. However, the ensemble simulations do not all agree on the sign of relative change. Changes in mean travel time exhibit a larger variability than those in groundwater levels. The ensemble simulations do not show a systematic relationship between the projected change (in both groundwater levels and travel times) and the warming level, but they indicate an increased variability in projected changes with adjusting the enhanced warming level from 1.5 to 3 ∘C. Correspondingly, it is highly recommended to restrain the trend of global warming. KW - climate change impacts KW - hydrological models KW - coupled surface KW - water fluxes KW - catchment KW - recharge KW - dynamics KW - aquifer KW - flow KW - parameterization Y1 - 2020 U6 - https://doi.org/10.5194/hess-24-1511-2020 SN - 1607-7938 SN - 1027-5606 VL - 24 IS - 3 SP - 1511 EP - 1526 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Pohl, Martin A1 - Macias, Oscar A1 - Coleman, Phaedra A1 - Gordon, Chris T1 - Assessing the impact of hydrogen absorption on the characteristics of the Galactic center excess JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We present a new reconstruction of the distribution of atomic hydrogen in the inner Galaxy that is based on explicit radiation transport modeling of line and continuum emission and a gas-flow model in the barred Galaxy that provides distance resolution for lines of sight toward the Galactic center. The main benefits of the new gas model are (a) the ability to reproduce the negative line signals seen with the HI4PI survey and (b) the accounting for gas that primarily manifests itself through absorption. We apply the new model of Galactic atomic hydrogen to an analysis of the diffuse gamma-ray emission from the inner Galaxy, for which an excess at a few GeV was reported that may be related to dark matter. We find with high significance an improved fit to the diffuse gamma-ray emission observed with the Fermi-LAT, if our new H i model is used to estimate the cosmic-ray induced diffuse gamma-ray emission. The fit still requires a nuclear bulge at high significance. Once this is included there is no evidence of a dark-matter signal, be it cuspy or cored. But an additional so-called boxy bulge is still favored by the data. This finding is robust under the variation of various parameters, for example, the excitation temperature of atomic hydrogen, and a number of tests for systematic issues. Y1 - 2022 U6 - https://doi.org/10.3847/1538-4357/ac6032 SN - 0004-637X SN - 1538-4357 VL - 929 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Francke, Till A1 - Heistermann, Maik A1 - Köhli, Markus A1 - Budach, Christian A1 - Schrön, Martin A1 - Oswald, Sascha T1 - Assessing the feasibility of a directional cosmic-ray neutron sensing sensor for estimating soil moisture JF - Geoscientific Instrumentation, Methods and Data Systems N2 - Cosmic-ray neutron sensing (CRNS) is a non-invasive tool for measuring hydrogen pools such as soil moisture, snow or vegetation. The intrinsic integration over a radial hectare-scale footprint is a clear advantage for averaging out small-scale heterogeneity, but on the other hand the data may become hard to interpret in complex terrain with patchy land use. This study presents a directional shielding approach to prevent neutrons from certain angles from being counted while counting neutrons entering the detector from other angles and explores its potential to gain a sharper horizontal view on the surrounding soil moisture distribution. Using the Monte Carlo code URANOS (Ultra Rapid Neutron-Only Simulation), we modelled the effect of additional polyethylene shields on the horizontal field of view and assessed its impact on the epithermal count rate, propagated uncertainties and aggregation time. The results demonstrate that directional CRNS measurements are strongly dominated by isotropic neutron transport, which dilutes the signal of the targeted direction especially from the far field. For typical count rates of customary CRNS stations, directional shielding of half-spaces could not lead to acceptable precision at a daily time resolution. However, the mere statistical distinction of two rates should be feasible. KW - water-balance KW - quantification KW - calibration KW - validation Y1 - 2021 U6 - https://doi.org/10.5194/gi-11-75-2022 SN - 2193-0864 SN - 2193-0856 VL - 11 SP - 75 EP - 92 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Walther, Sophia A1 - Guanter, Luis A1 - Heim, Birgit A1 - Jung, Martin A1 - Duveiller, Gregory A1 - Wolanin, Aleksandra A1 - Sachs, Torsten T1 - Assessing the dynamics of vegetation productivity in circumpolar regions with different satellite indicators of greenness and photosynthesis JF - Biogeosciences N2 - High-latitude treeless ecosystems represent spatially highly heterogeneous landscapes with small net carbon fluxes and a short growing season. Reliable observations and process understanding are critical for projections of the carbon balance of the climate-sensitive tundra. Space-borne remote sensing is the only tool to obtain spatially continuous and temporally resolved information on vegetation greenness and activity in remote circumpolar areas. However, confounding effects from persistent clouds, low sun elevation angles, numerous lakes, widespread surface inundation, and the sparseness of the vegetation render it highly challenging. Here, we conduct an extensive analysis of the timing of peak vegetation productivity as shown by satellite observations of complementary indicators of plant greenness and photosynthesis. We choose to focus on productivity during the peak of the growing season, as it importantly affects the total annual carbon uptake. The suite of indicators are as follows: (1) MODIS-based vegetation indices (VIs) as proxies for the fraction of incident photosynthetically active radiation (PAR) that is absorbed (fPAR), (2) VIs combined with estimates of PAR as a proxy of the total absorbed radiation (APAR), (3) sun-induced chlorophyll fluorescence (SIF) serving as a proxy for photosynthesis, (4) vegetation optical depth (VOD), indicative of total water content and (5) empirically upscaled modelled gross primary productivity (GPP). Averaged over the pan-Arctic we find a clear order of the annual peak as APAR <= GPP < SIF < VIs/VOD. SIF as an indicator of photosynthesis is maximised around the time of highest annual temperatures. The modelled GPP peaks at a similar time to APAR. The time lag of the annual peak between APAR and instantaneous SIF fluxes indicates that the SIF data do contain information on light-use efficiency of tundra vegetation, but further detailed studies are necessary to verify this. Delayed peak greenness compared to peak photosynthesis is consistently found across years and land-cover classes. A particularly late peak of the normalised difference vegetation index (NDVI) in regions with very small seasonality in greenness and a high amount of lakes probably originates from artefacts. Given the very short growing season in circumpolar areas, the average time difference in maximum annual photosynthetic activity and greenness or growth of 3 to 25 days (depending on the data sets chosen) is important and needs to be considered when using satellite observations as drivers in vegetation models. Y1 - 2018 U6 - https://doi.org/10.5194/bg-15-6221-2018 SN - 1726-4170 SN - 1726-4189 VL - 15 IS - 20 SP - 6221 EP - 6256 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Fanselow, Gisbert A1 - Zimmermann, Malte A1 - Philipp, Mareike T1 - Assessing the availability of inverse scope in German in the covered box paradigm JF - Glossa : a journal of general linguistics N2 - This paper presents the results of a novel experimental approach to relative quantifier scope in German that elicits data in an indirect manner. Applying the covered-box method (Huang et al. 2013) to scope phenomena, we show that inverse scope is available to some extent in the free constituent order language German, thereby validating earlier findings on other syntactic configurations in German (Rado & Bott 2018) and empirical claims on other free constituent order languages (Japanese, Russian, Hindi), as well as recent corpus findings in Webelhuth (2020). Moreover, the results of the indirect covered-box experiment replicate findings from an earlier direct-query experiment with comparable target items, in which participants were asked directly about the availability of surface scope and inverse scope readings. The configuration of interest consisted of canonical transitive clauses with deaccented existential subject and universal object QPs, in which the restriction of the universal QP was controlled for by the context. KW - inverse scope KW - covered-box KW - free constituent order KW - German KW - experimental semantics Y1 - 2022 U6 - https://doi.org/10.16995/glossa.5766 SN - 2397-1835 VL - 7 IS - 1 SP - 1 EP - 24 PB - Open Library of Humanities CY - London ER - TY - JOUR A1 - Gasparatos, Nikolaos A1 - Scheffler, Christiane A1 - Hermanussen, Michael T1 - Assessing the applicability of changepoint analysis to analyse short-term growth JF - Human biology and public health N2 - Background: Assessing short-term growth in humans is still fraught with difficulties. Especially when looking for small variations and increments, such as mini growth spurts, high precision instruments or frequent measurements are necessary. Daily measurements however require a lot of effort, both for anthropologists and for the subjects. Therefore, new sophisticated approaches are needed that reduce fluctuations and reveal underlying patterns. Objectives: Changepoints are abrupt variations in the properties of time series data. In the context of growth, such variations could be variation in mean height. By adjusting the variance and using different growth models, we assessed the ability of changepoint analysis to analyse short-term growth and detect mini growth spurts. Sample and Methods: We performed Bayesian changepoint analysis on simulated growth data using the bcp package in R. Simulated growth patterns included stasis, linear growth, catch-up growth, and mini growth spurts. Specificity and a normalised variant of the Matthews correlation coefficient (MCC) were used to assess the algorithm’s performance. Welch’s t-test was used to compare differences of the mean. Results: First results show that changepoint analysis can detect mini growth spurts. However, the ability to detect mini growth spurts is highly dependent on measurement error. Data preparation, such as ranking and rotating time series data, showed negligible improvements. Missing data was an issue and may affect the prediction quality of the classification metrics. Conclusion: Changepoint analysis is a promising tool to analyse short-term growth. However, further optimisation and analysis of real growth data is needed to make broader generalisations. KW - changepoint analysis KW - changepoint detection KW - performance evaluation KW - mini growth spurt KW - short-term growth Y1 - 2023 U6 - https://doi.org/10.52905/hbph2023.1.62 SN - 2748-9957 VL - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Kühne, Franziska T1 - Assessing Patient Preferences BT - Examination of the German Cooper-Norcross Inventory of Preferences JF - Frontiers in Psychology N2 - Despite the positive effects of including patients’ preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. KW - psychotherapy KW - preference KW - activity preference KW - preference assessment KW - validation study Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.795776 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Kühne, Franziska T1 - Assessing patient preferences BT - examination of the german cooper-norcross inventory of preferences JF - Frontiers in psychology N2 - Despite the positive effects of including patients' preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. KW - psychotherapy KW - preference KW - activity preference KW - preference assessment KW - validation study Y1 - 2022 U6 - https://doi.org/10.3389/fpsyg.2021.795776 SN - 1664-1078 VL - 12 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Smith, Taylor A1 - Bookhagen, Bodo T1 - Assessing Multi-Temporal Snow-Volume Trends in High Mountain Asia From 1987 to 2016 Using High-Resolution Passive Microwave Data JF - Frontiers in Earth Science N2 - High Mountain Asia (HMA) is dependent upon both the amount and timing of snow and glacier meltwater. Previous model studies and coarse resolution (0.25° × 0.25°, ∼25 km × 25 km) passive microwave assessments of trends in the volume and timing of snowfall, snowmelt, and glacier melt in HMA have identified key spatial and seasonal heterogeneities in the response of snow to changes in regional climate. Here we use recently developed, continuous, internally consistent, and high-resolution passive microwave data (3.125 km × 3.125 km, 1987–2016) from the special sensor microwave imager instrument family to refine and extend previous estimates of changes in the snow regime of HMA. We find an overall decline in snow volume across HMA; however, there exist spatially contiguous regions of increasing snow volume—particularly during the winter season in the Pamir, Karakoram, Hindu Kush, and Kunlun Shan. Detailed analysis of changes in snow-volume trends through time reveal a large step change from negative trends during the period 1987–1997, to much more positive trends across large regions of HMA during the periods 1997–2007 and 2007–2016. We also find that changes in high percentile monthly snow-water volume exhibit steeper trends than changes in low percentile snow-water volume, which suggests a reduction in the frequency of high snow-water volumes in much of HMA. Regions with positive snow-water storage trends generally correspond to regions of positive glacier mass balances. KW - snow KW - glacier KW - climate change KW - passive microwave KW - special sensor microwave imager KW - special sensor microwave imager/sounder Y1 - 2020 U6 - https://doi.org/10.3389/feart.2020.559175 SN - 2296-6463 VL - 8 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Jesus, Sonia A. A1 - Schmidt, Anke A1 - Fickel, Jörns A1 - Doherr, Marcus G. A1 - Boonprasert, Khajohnpat A1 - Thitaram, Chatchote A1 - Sariya, Ladawan A1 - Ratanakron, Parntep A1 - Hildebrandt, Thomas Bernd T1 - Assessing coagulation parameters in healthy Asian Elephants (Elephas maximus) from European and thai populations JF - Animals N2 - Simple Summary Asian elephants (Elephas maximus) are considered endangered and their population is in continuous decline. Understanding their social interactions, health, and welfare status has been a topic of intense research in recent decades. Coagulation assessments have been underutilized in wildlife but can give valuable information on individual health. This study aims to increase the knowledge of the coagulation status in healthy Asian elephants from different backgrounds and age groups, using a fast point-of-care analyzer. This tool can be further used in either routine health check-ups performed by caretakers or in a clinical emergency, such as in cases of elephant endotheliotropic herpesvirus hemorrhagic disease outbreaks. We have also investigated the presence of genomic mutations in one coagulation factor-factor VII-where a disorder was previously reported in an Asian elephant. Hereby, we report new reference values for coagulation parameters, such as coagulation times and fibrinogen concentration of Asian elephants assessed in Thailand and in Europe, as well as several single point mutations found in the exons of Elephas maximus coagulation F7 gene. We found the point-of-care analyzer used in this study to be very practical and user friendly for a zoo and field environment and hope that this project will incentivize further coagulation studies in Asian elephants and in other wildlife species. The Asian elephant population is continuously declining due to several extrinsic reasons in their range countries, but also due to diseases in captive populations worldwide. One of these diseases, the elephant endotheliotropic herpesvirus (EEHV) hemorrhagic disease, is very impactful because it particularly affects Asian elephant calves. It is commonly fatal and presents as an acute and generalized hemorrhagic syndrome. Therefore, having reference values of coagulation parameters, and obtaining such values for diseased animals in a very short time, is of great importance. We analyzed prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen concentrations using a portable and fast point-of-care analyzer (VetScan Pro) in 127 Asian elephants from Thai camps and European captive herds. We found significantly different PT and aPTT coagulation times between elephants from the two regions, as well as clear differences in fibrinogen concentration. Nevertheless, these alterations were not expected to have biological or clinical implications. We have also sequenced the coagulation factor VII gene of 141 animals to assess the presence of a previously reported hereditary coagulation disorder in Asian elephants and to investigate the presence of other mutations. We did not find the previously reported mutation in our study population. Instead, we discovered the presence of several new single nucleotide polymorphisms, two of them being considered as deleterious by effect prediction software. KW - coagulation KW - Asian elephant KW - EEHV KW - factor VII KW - F7 gene KW - prothrombin KW - activated PTT KW - fibrinogen Y1 - 2022 U6 - https://doi.org/10.3390/ani12030361 SN - 2076-2615 VL - 12 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Hoffmann, Holger A1 - Ott, Christiane A1 - Raupbach, Jana A1 - Andernach, Lars A1 - Renz, Matthias A1 - Grune, Tilman A1 - Hanschen, Franziska S. T1 - Assessing bioavailability and bioactivity of 4-Hydroxythiazolidine-2-Thiones, newly discovered glucosinolate degradation products formed during domestic boiling of cabbage JF - Frontiers in nutrition N2 - Glucosinolates are plant secondary metabolites found in cruciferous vegetables (Brassicaceae) that are valued for their potential health benefits. Frequently consumed representatives of these vegetables, for example, are white or red cabbage, which are typically boiled before consumption. Recently, 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were identified as a class of thermal glucosinolate degradation products that are formed during the boiling of cabbage. Since these newly discovered compounds are frequently consumed, this raises questions about their potential uptake and their possible bioactive functions. Therefore, 3-allyl-4-hydroxythiazolidine-2-thione (allyl HTT) and 4-hydroxy-3-(4-(methylsulfinyl) butyl)thiazolidine-2-thione (4-MSOB HTT) as degradation products of the respective glucosinolates sinigrin and glucoraphanin were investigated. After consumption of boiled red cabbage broth, recoveries of consumed amounts of the degradation products in urine collected for 24 h were 18 +/- 5% for allyl HTT and 21 +/- 4% for 4-MSOB HTT (mean +/- SD, n = 3). To investigate the stability of the degradation products during uptake and to elucidate the uptake mechanism, both an in vitro stomach and an in vitro intestinal model were applied. The results indicate that the uptake of allyl HTT and 4-MSOB HTT occurs by passive diffusion. Both compounds show no acute cell toxicity, no antioxidant potential, and no change in NAD(P)H dehydrogenase quinone 1 (NQO1) activity up to 100 mu M. However, inhibition of glycogen synthase kinases-3 (GSK-3) in the range of 20% for allyl HTT for the isoform GSK-3 beta and 29% for 4-MSOB HTT for the isoform GSK-3 alpha at a concentration of 100 mu M was found. Neither health-promoting nor toxic effects of 3-alk(en)yl-4-hydroxythiazolidine-2-thiones were found in the four tested assays carried out in this study, which contrasts with the properties of other glucosinolate degradation products, such as isothiocyanates. KW - stomach model KW - glycogen synthase kinase-3 KW - cytotoxicity KW - antioxidant potential KW - intestinal model KW - cellular uptake KW - isothiocyanate Y1 - 2022 U6 - https://doi.org/10.3389/fnut.2022.941286 SN - 2296-861X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Heyd, Thomas T1 - Ascensión al Teide de Alexander von Humboldt JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - En este breve ensayo propongo que en la ascensión al Teide Alexander von Humboldt pudo adquirir una perspectiva integral, que le sirvió como marco de comunicación científica para aunar la multitud de datos que se había dispuesto a recoger en su breve estancia en la isla. Más aun, de ahí en adelante este marco además le serviría para darle sentido de conjunto a las incontables y diversas informaciones que recogería en los restantes cinco años de viaje. Para poner en evidencia el enfoque de la visita a Tenerife de Humboldt, analizo su relato de la ascensión al Teide suponiendo que está estructurado según los relatos de viajes épicos y peregrinaciones. N2 - In dieser kurzen Abhandlung wird dargelegt, dass Alexander von Humboldt durch die Besteigung des Teide eine integrierende Perspektive erwerben konnte, die ihm als Rahmen wissenschaftlicher Kommunikation dienen würde um die Vielzahl der Daten, welche er sich vorgenommen hatte auf der Insel zu sammeln, zu vereinen. Darüber hinaus wird ihm dieser Rahmen von hier an auch dazu dienen, um den unzähligen und verschiedenartigen Informationen, die er in den verbleibenden fünf Reisejahren sammeln würde, einen einheitlichen Sinn zu geben. Um die Blickrichtung von Humboldts Besuch auf Teneriffa darzulegen, untersuche ich seinen Bericht über die Besteigung des Teide unter der Annahme, dass er den Aufbau epischer Reisen und Pilgerfahrten hat. N2 - In this brief essay I propose that, with the ascent of the Teide, Alexander von Humboldt was able to acquire an integrating perspective that served him as a framework for scientific communication to unify the multitude of data that he had set out to collect during his brief stay on the island. Moreover, thereafter this framework would also serve him to give a unified sense to the countless and diverse kinds of information that he could collect during the remaining five years of travel. To bring out the focus of Humboldt’s visit to Tenerife, I analyse his account of the ascent of the Teide by assuming that it is structured in the manner of the stories of epic journeys and pilgrimages. KW - Bergbesteigung KW - Tenerife KW - Teneriffa KW - Vulkanlandschaften Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-86956 SN - 1617-5239 SN - 2568-3543 VL - XVI IS - 30 SP - 68 EP - 77 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Herrero, Mario A1 - Thornton, Philip K. A1 - Mason-D'Croz, Daniel A1 - Palmer, Jeda A1 - Bodirsky, Benjamin Leon A1 - Pradhan, Prajal A1 - Barrett, Christopher B. A1 - Benton, Tim G. A1 - Hall, Andrew A1 - Pikaar, Ilje A1 - Bogard, Jessica R. A1 - Bonnett, Graham D. A1 - Bryan, Brett A. A1 - Campbell, Bruce M. A1 - Christensen, Svend A1 - Clark, Michael A1 - Fanzo, Jessica A1 - Godde, Cecile M. A1 - Jarvis, Andy A1 - Loboguerrero, Ana Maria A1 - Mathys, Alexander A1 - McIntyre, C. Lynne A1 - Naylor, Rosamond L. A1 - Nelson, Rebecca A1 - Obersteiner, Michael A1 - Parodi, Alejandro A1 - Popp, Alexander A1 - Ricketts, Katie A1 - Smith, Pete A1 - Valin, Hugo A1 - Vermeulen, Sonja J. A1 - Vervoort, Joost A1 - van Wijk, Mark A1 - van Zanten, Hannah H. E. A1 - West, Paul C. A1 - Wood, Stephen A. A1 - Rockström, Johan T1 - Articulating the effect of food systems innovation on the Sustainable Development Goals JF - The lancet Planetary health N2 - Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level. Y1 - 2020 U6 - https://doi.org/10.1016/S2542-5196(20)30277-1 SN - 2542-5196 VL - 5 IS - 1 SP - E50 EP - E62 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Thulin, Mirjam T1 - Arthur Czellitzer (1871 – 1943) and the society for Jewish family research JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture N2 - In 1924, the Berlin ophthalmologist Arthur Czellitzer (1871–1943) and like-minded members of the local Jewish community founded the Society for Jewish Family Research. A year later, the Society launched the journal Jüdische Familienforschung (Jewish Family Research), edited by Czellitzer. The Society was an outstanding platform of professional academic and amateur researchers and promoted a type of Jewish genealogy and family history that was shaped by the historical-medical discourse of the time. The concepts and methods of both the biological sciences and Wissenschaft des Judentums shaped and defined the academic approach to family research and history in Czellitzer’s and the Society’s work. The Society soon became the leading international association for the academic Jewish genealogical research. Despite of its brutal end in 1938, Arthur Czellitzer’s and the Society’s works, the issues raised, and the methods they created shape Jewish family research and genealogy until today. Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485534 SN - 978-3-86956-493-7 SN - 1614-6492 SN - 1862-7684 IS - 26 SP - 29 EP - 42 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Garrido, Elisa T1 - Arte, ciencia y cultura visual en el atlas pintoresco BT - vista de la Plaza Mayor de Mexico JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - Lo pintoresco se puede definir como un sentimiento que invita al espectador de una escena particular a reproducirla en un cuadro, algo que permitió a los viajeros del siglo XIX transportar las imágenes como posesiones, especialmente a través de la publicación de un Atlas Pittoresque. Cada una de esas imágenes es un testimonio de los viajes y sus historias cruzadas. Este es el caso de la lámina III, Vista de la Plaza Mayor de México, que forma parte de la obra Vues des Cordillères et Monuments des Peuples Indigènes de l’Amérique, una imagen que ilustra las redes de intercambio que se sucedían entre artistas y científicos a través de los viajes y expediciones. N2 - The picturesque can be explained as a feeling that invites the viewer of a particular scene to be reproduced in a frame, which allowed the travellers to move images as possessions, especially through the publication of the Atlas Pittoresque. Each of these images is a testimony of interlinked travelogues. This is the case of the Plate III, Vue de la Grande Place de Mexico in Vues des Cordillères et Monuments des Peuples Indigènes de l’Amérique, an image illustrating the exchange networks that were happening between artists and scientists through the travels and expeditions. N2 - On peut définir le pittoresque comme un sentiment invitant le spectateur d’une scène particulière à la reproduire dans un tableau, et qui a permis aux voyageurs de transporter les images comme des possessions, particulièrement vers la publication d’un Atlas Pittoresque. Chacune de ces images est un témoignage des voyages et ses histoires croisées. C‘est le cas de la Planche III, Vue de la Grande Place de Mexico, qu’appartiennent aux Vues des Cordillères et Monuments des Peuples Indigènes de l’Amérique, une image représentant des réseaux d‘échanges entre les artistes et les scientifiques vers les voyages et les expéditions. KW - Bildtafeln KW - México KW - Plaza Mayor KW - Reiterstandbild KW - Vues des Cordilleres Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-86949 SN - 1617-5239 SN - 2568-3543 VL - XVI IS - 30 SP - 54 EP - 67 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Georgiev, Vasil N. A1 - Grafmüller, Andrea A1 - Bléger, David A1 - Hecht, Stefan A1 - Kunstmann, Sonja A1 - Barbirz, Stefanie A1 - Lipowsky, Reinhard A1 - Dimova, Rumiana T1 - Area increase and budding in giant vesicles triggered by light BT - behind the scene JF - Advanced science N2 - Biomembranes are constantly remodeled and in cells, these processes are controlled and modulated by an assortment of membrane proteins. Here, it is shown that such remodeling can also be induced by photoresponsive molecules. The morphological control of giant vesicles in the presence of a water-soluble ortho-tetrafluoroazobenzene photoswitch (F-azo) is demonstrated and it is shown that the shape transformations are based on an increase in membrane area and generation of spontaneous curvature. The vesicles exhibit budding and the buds can be retracted by using light of a different wavelength. In the presence of F-azo, the membrane area can increase by more than 5% as assessed from vesicle electrodeformation. To elucidate the underlying molecular mechanism and the partitioning of F-azo in the membrane, molecular dynamics simulations are employed. Comparison with theoretically calculated shapes reveals that the budded shapes are governed by curvature elasticity, that the spontaneous curvature can be decomposed into a local and a nonlocal contribution, and that the local spontaneous curvature is about 1/(2.5 mu m). The results show that exo- and endocytotic events can be controlled by light and that these photoinduced processes provide an attractive method to change membrane area and morphology. KW - azobenzene KW - lipid membranes KW - molecular dynamics KW - photoswitch KW - vesicles Y1 - 2018 U6 - https://doi.org/10.1002/advs.201800432 SN - 2198-3844 VL - 5 IS - 8 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Hoffmann, Lisa A1 - Wilbert, Jürgen A1 - Lehofer, Mike A1 - Schwab, Susanne T1 - Are we good friends? BT - Friendship preferences and the quantity and quality of mutual friendships JF - European Journal of Special Needs Education N2 - Empirical studies already examined various facets of the friendship construct. Building on this, the present study examines the questions of how the number of friendships and their quality differ between students with and without SEN and whether a homophily-effect can be identified. The sample consists of 455 fourth-graders from 28 inclusive classes in Austria. The results indicate that students with SEN have fewer friends than students without SEN. Furthermore, students without SEN preferred peers without SEN as a friend. This homophily-effect was shown for students with SEN, too. However, students with and without SEN rated the quality of their friendships similarly and no interactions between the SEN status of oneself or of the friend was found for the quality of the friendship. The results show that, in the context of inclusion, the issue of friendship needs to be increasingly addressed to improve the situation of students with SEN. KW - social participation KW - friendship KW - quality of friendship KW - homophily KW - sociometric nomination Y1 - 2019 VL - 36 IS - 4 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Schreiber, Alexander A1 - Onea Gáspár, Edgar T1 - Are narrow focus exhaustivity inferences Bayesian inferences? JF - Frontiers in psychology / Frontiers Research Foundation N2 - In successful communication, the literal meaning of linguistic utterances is often enriched by pragmatic inferences. Part of the pragmatic reasoning underlying such inferences has been successfully modeled as Bayesian goal recognition in the Rational Speech Act (RSA) framework. In this paper, we try to model the interpretation of question-answer sequences with narrow focus in the answer in the RSA framework, thereby exploring the effects of domain size and prior probabilities on interpretation. Should narrow focus exhaustivity inferences be actually based on Bayesian inference involving prior probabilities of states, RSA models should predict a dependency of exhaustivity on these factors. We present experimental data that suggest that interlocutors do not act according to the predictions of the RSA model and that exhaustivity is in fact approximately constant across different domain sizes and priors. The results constitute a conceptual challenge for Bayesian accounts of the underlying pragmatic inferences. KW - pragmatics KW - Bayesian models KW - rational speech act models KW - implicatures KW - focus KW - exhaustivity Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.677223 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Nevill, Alan M. A1 - Negra, Yassine A1 - Myers, Tony D. A1 - Duncan, Michael J. A1 - Chaabene, Helmi A1 - Granacher, Urs T1 - Are Early or Late Maturers Likely to Be Fitter in the General Population? JF - International Journal of Environmental Research and Public Health N2 - The present study aims to identify the optimal body-size/shape and maturity characteristics associated with superior fitness test performances having controlled for body-size, sex, and chronological-age differences. The sample consisted of 597 Tunisian children (396 boys and 201 girls) aged 8 to 15 years. Three sprint speeds recorded at 10, 20 and 30 m; two vertical and two horizontal jump tests; a change-of-direction and a handgrip-strength tests, were assessed during physical-education classes. Allometric modelling was used to identify the benefit of being an early or late maturer. Findings showed that being tall and light is the ideal shape to be successful at most physical fitness tests, but the height-to-weight “shape” ratio seems to be test-dependent. Having controlled for body-size/shape, sex, and chronological age, the model identified maturity-offset as an additional predictor. Boys who go earlier/younger through peak-height-velocity (PHV) outperform those who go at a later/older age. However, most of the girls’ physical-fitness tests peaked at the age at PHV and decline thereafter. Girls whose age at PHV was near the middle of the age range would appear to have an advantage compared to early or late maturers. These findings have important implications for talent scouts and coaches wishing to recruit children into their sports/athletic clubs. KW - youth KW - fitness tests KW - allometry KW - body shape KW - biological age Y1 - 2021 U6 - https://doi.org/10.3390/ijerph18020497 SN - 1660-4601 VL - 18 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Rolph, Rebecca A1 - Overduin, Pier Paul A1 - Ravens, Thomas A1 - Lantuit, Hugues A1 - Langer, Moritz T1 - ArcticBeach v1.0 BT - a physics-based parameterization of pan-Arctic coastline erosion JF - Frontiers in Earth Science N2 - In the Arctic, air temperatures are increasing and sea ice is declining, resulting in larger waves and a longer open water season, all of which intensify the thaw and erosion of ice-rich coasts. Climate change has been shown to increase the rate of Arctic coastal erosion, causing problems for Arctic cultural heritage, existing industrial, military, and civil infrastructure, as well as changes in nearshore biogeochemistry. Numerical models that reproduce historical and project future Arctic erosion rates are necessary to understand how further climate change will affect these problems, and no such model yet exists to simulate the physics of erosion on a pan-Arctic scale. We have coupled a bathystrophic storm surge model to a simplified physical erosion model of a permafrost coastline. This Arctic erosion model, called ArcticBeach v1.0, is a first step toward a physical parameterization of Arctic shoreline erosion for larger-scale models. It is forced by wind speed and direction, wave period and height, sea surface temperature, all of which are masked during times of sea ice cover near the coastline. Model tuning requires observed historical retreat rates (at least one value), as well as rough nearshore bathymetry. These parameters are already available on a pan-Arctic scale. The model is validated at three study sites at 1) Drew Point (DP), Alaska, 2) Mamontovy Khayata (MK), Siberia, and 3) Veslebogen Cliffs, Svalbard. Simulated cumulative retreat rates for DP and MK respectively (169 and 170 m) over the time periods studied at each site (2007-2016, and 1995-2018) are found to the same order of magnitude as observed cumulative retreat (172 and 120 m). The rocky Veslebogen cliffs have small observed cumulative retreat rates (0.05 m over 2014-2016), and our model was also able to reproduce this same order of magnitude of retreat (0.08 m). Given the large differences in geomorphology between the study sites, this study provides a proof-of-concept that ArcticBeach v1.0 can be applied on very different permafrost coastlines. ArcticBeach v1.0 provides a promising starting point to project retreat of Arctic shorelines, or to evaluate historical retreat in places that have had few observations. KW - permafrost KW - erosion KW - modelling KW - arctic KW - climate change Y1 - 2022 U6 - https://doi.org/10.3389/feart.2022.962208 SN - 2296-6463 VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Radosavljevic, Boris A1 - Lantuit, Hugues A1 - Knoblauch, Christian A1 - Couture, Nicole A1 - Herzschuh, Ulrike A1 - Fritz, Michael T1 - Arctic nearshore sediment dynamics - an example from Herschel Island - Qikiqtaruk, Canada JF - Journal of marine science and engineering N2 - Increasing arctic coastal erosion rates imply a greater release of sediments and organic matter into the coastal zone. With 213 sediment samples taken around Herschel Island-Qikiqtaruk, Canadian Beaufort Sea, we aimed to gain new insights on sediment dynamics and geochemical properties of a shallow arctic nearshore zone. Spatial characteristics of nearshore sediment texture (moderately to poorly sorted silt) are dictated by hydrodynamic processes, but ice-related processes also play a role. We determined organic matter (OM) distribution and inferred the origin and quality of organic carbon by C/N ratios and stable carbon isotopes delta C-13. The carbon content was higher offshore and in sheltered areas (mean: 1.0 wt.%., S.D.: 0.9) and the C/N ratios also showed a similar spatial pattern (mean: 11.1, S.D.: 3.1), while the delta C-13 (mean: -26.4 parts per thousand VPDB, S.D.: 0.4) distribution was more complex. We compared the geochemical parameters of our study with terrestrial and marine samples from other studies using a bootstrap approach. Sediments of the current study contained 6.5 times and 1.8 times less total organic carbon than undisturbed and disturbed terrestrial sediments, respectively. Therefore, degradation of OM and separation of carbon pools take place on land and continue in the nearshore zone, where OM is leached, mineralized, or transported beyond the study area. KW - permafrost KW - Arctic Ocean KW - stable carbon isotopes KW - nitrogen KW - sediment KW - chemistry KW - sediment dynamics KW - Beaufort Sea KW - grain size Y1 - 2022 U6 - https://doi.org/10.3390/jmse10111589 SN - 2077-1312 VL - 10 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Casado, Mathieu A1 - Landais, Amaelle A1 - Picard, Ghislain A1 - Münch, Thomas A1 - Laepple, Thomas A1 - Stenni, Barbara A1 - Dreossi, Giuliano A1 - Ekaykin, Alexey A1 - Arnaud, Laurent A1 - Genthon, Christophe A1 - Touzeau, Alexandra A1 - Masson-Delmotte, Valerie A1 - Jouzel, Jean T1 - Archival processes of the water stable isotope signal in East Antarctic ice cores JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - The oldest ice core records are obtained from the East Antarctic Plateau. Water isotopes are key proxies to reconstructing past climatic conditions over the ice sheet and at the evaporation source. The accuracy of climate reconstructions depends on knowledge of all processes affecting water vapour, precipitation and snow isotopic compositions. Fractionation processes are well understood and can be integrated in trajectory-based Rayleigh distillation and isotope-enabled climate models. However, a quantitative understanding of processes potentially altering snow isotopic composition after deposition is still missing. In low-accumulation sites, such as those found in East Antarctica, these poorly constrained processes are likely to play a significant role and limit the interpretability of an ice core's isotopic composition. By combining observations of isotopic composition in vapour, precipitation, surface snow and buried snow from Dome C, a deep ice core site on the East Antarctic Plateau, we found indications of a seasonal impact of metamorphism on the surface snow isotopic signal when compared to the initial precipitation. Particularly in summer, exchanges of water molecules between vapour and snow are driven by the diurnal sublimation-condensation cycles. Overall, we observe in between precipitation events modification of the surface snow isotopic composition. Using high-resolution water isotopic composition profiles from snow pits at five Antarctic sites with different accumulation rates, we identified common patterns which cannot be attributed to the seasonal variability of precipitation. These differences in the precipitation, surface snow and buried snow isotopic composition provide evidence of post-deposition processes affecting ice core records in low-accumulation areas. Y1 - 2018 U6 - https://doi.org/10.5194/tc-12-1745-2018 SN - 1994-0416 SN - 1994-0424 VL - 12 IS - 5 SP - 1745 EP - 1766 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Hargis, Hailey A1 - Gotsch, Sybil G. A1 - Porada, Philipp A1 - Moore, Georgianne W. A1 - Ferguson, Briana A1 - Van Stan, John T. T1 - Arboreal epiphytes in the soil-atmosphere interface BT - how often are the biggest "buckets" in the canopy empty? JF - Geosciences N2 - Arboreal epiphytes (plants residing in forest canopies) are present across all major climate zones and play important roles in forest biogeochemistry. The substantial water storage capacity per unit area of the epiphyte "bucket" is a key attribute underlying their capability to influence forest hydrological processes and their related mass and energy flows. It is commonly assumed that the epiphyte bucket remains saturated, or near-saturated, most of the time; thus, epiphytes (particularly vascular epiphytes) can store little precipitation, limiting their impact on the forest canopy water budget. We present evidence that contradicts this common assumption from (i) an examination of past research; (ii) new datasets on vascular epiphyte and epi-soil water relations at a tropical montane cloud forest (Monteverde, Costa Rica); and (iii) a global evaluation of non-vascular epiphyte saturation state using a process-based vegetation model, LiBry. All analyses found that the external and internal water storage capacity of epiphyte communities is highly dynamic and frequently available to intercept precipitation. Globally, non-vascular epiphytes spend <20% of their time near saturation and regionally, including the humid tropics, model results found that non-vascular epiphytes spend similar to 1/3 of their time in the dry state (0-10% of water storage capacity). Even data from Costa Rican cloud forest sites found the epiphyte community was saturated only 1/3 of the time and that internal leaf water storage was temporally dynamic enough to aid in precipitation interception. Analysis of the epi-soils associated with epiphytes further revealed the extent to which the epiphyte bucket emptied-as even the canopy soils were often <50% saturated (29-53% of all days observed). Results clearly show that the epiphyte bucket is more dynamic than currently assumed, meriting further research on epiphyte roles in precipitation interception, redistribution to the surface and chemical composition of "net" precipitation waters reaching the surface. KW - precipitation KW - interception KW - bromeliad KW - vascular epiphyte KW - non-vascular epiphyte KW - lichens KW - bryophytes KW - water storage capacity Y1 - 2019 U6 - https://doi.org/10.3390/geosciences9080342 SN - 2076-3263 VL - 9 IS - 8 PB - MDPI CY - Basel ER - TY - CHAP A1 - Czychowski, Christian A1 - Düstersiek, Niclas ED - Schrör, Simon ED - Fischer, Georg ED - Beaucamp, Sophie ED - Hondros, Konstantin T1 - Appropriation Art BT - in Zeiten von "Metall auf Metall" und des Internets T2 - Tipping Points : interdisziplinäre Zugänge zu neuen Fragen des Urheberrechts Y1 - 2020 SN - 978-3-7489-1066-4 SN - 978-3-8487-6957-5 U6 - https://doi.org/10.5771/9783748910664-199 SP - 199 EP - 220 PB - Nomos CY - Baden-Baden ER - TY - JOUR A1 - Wochatz, Monique A1 - Schraplau, Anne A1 - Engel, Tilman A1 - Zecher, Mahli Megan A1 - Sharon, Hadar A1 - Alt, Yasmin A1 - Mayer, Frank A1 - Kalron, Alon T1 - Application of eccentric training in various clinical populations BT - Protocol for a multi-centered pilot and feasibility study in people with low back pain and people with multiple sclerosis JF - PLoS ONE N2 - Physical activity and exercise are effective approaches in prevention and therapy of multiple diseases. Although the specific characteristics of lengthening contractions have the potential to be beneficial in many clinical conditions, eccentric training is not commonly used in clinical populations with metabolic, orthopaedic, or neurologic conditions. The purpose of this pilot study is to investigate the feasibility, functional benefits, and systemic responses of an eccentric exercise program focused on the trunk and lower extremities in people with low back pain (LBP) and multiple sclerosis (MS). A six-week eccentric training program with three weekly sessions is performed by people with LBP and MS. The program consists of ten exercises addressing strength of the trunk and lower extremities. The study follows a four-group design (N = 12 per group) in two study centers (Israel and Germany): three groups perform the eccentric training program: A) control group (healthy, asymptomatic); B) people with LBP; C) people with MS; group D (people with MS) receives standard care physiotherapy. Baseline measurements are conducted before first training, post-measurement takes place after the last session both comprise blood sampling, self-reported questionnaires, mobility, balance, and strength testing. The feasibility of the eccentric training program will be evaluated using quantitative and qualitative measures related to the study process, compliance and adherence, safety, and overall program assessment. For preliminary assessment of potential intervention effects, surrogate parameters related to mobility, postural control, muscle strength and systemic effects are assessed. The presented study will add knowledge regarding safety, feasibility, and initial effects of eccentric training in people with orthopaedic and neurological conditions. The simple exercises, that are easily modifiable in complexity and intensity, are likely beneficial to other populations. Thus, multiple applications and implementation pathways for the herein presented training program are conceivable. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0270875 SN - 1932-6203 VL - 17 IS - 12 PB - Public Library of Science CY - San Francisco, California, USA ER - TY - JOUR A1 - Leinweber, Juliane T1 - App-Einsatz in der Logopädie/Sprachtherapie: Strategien und Kriterien JF - Spektrum Patholinguistik Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510199 SN - 978-3-86956-507-1 SN - 1866-9085 SN - 1866-9433 IS - 14 SP - 69 EP - 76 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ortiz Sotelo, Jorge T1 - Aportes de Humboldt BT - A la náutica y a la oceanografía peruana N2 - La corta estadía de Alexander von Humboldt en el Perú dejó su huella más notoria en el estudio que realizara del sistema de corrientes marítimas que fluyen delante de la costa peruana, bautizada en su honor Corriente de Humboldt o la Corriente Peruana. Para ello llevó a cabo varias mediciones de la temperatura de mar durante su viaje de Trujillo a Lima, durante su permanencia en El Callao, y en el viaje que realizó entre dicho puerto y Guayaquil a bordo de la corbeta de la Real Armada Castor. Por otro lado, con la colaboración de algunos oficiales de la Real Armada estacionados en El Callao realizó observaciones astronómicas que le permitieron determinar con mayor precisión la longitud del puerto de El Callao. En este trabajo se abordan estos aspectos de la presencia de Humboldt en el Perú. KW - Ozeanologie KW - Perú Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41686 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 23 EP - 31 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hülscher, Julian A1 - Sobel, Edward A1 - Kallnik, Niklas A1 - Hoffmann, J. Elis A1 - Millar, Ian L. A1 - Hartmann, Kai A1 - Bernhardt, Anne T1 - Apatites record sedimentary provenance change 4-5 myrs before clay in the Oligocene/Miocene Alpine molasse JF - Frontiers in Earth Science N2 - Extracting information about past tectonic or climatic environmental changes from sedimentary records is a key objective of provenance research. Interpreting the imprint of such changes remains challenging as signals might be altered in the sediment-routing system. We investigate the sedimentary provenance of the Oligocene/Miocene Upper Austrian Northern Alpine Foreland Basin and its response to the tectonically driven exhumation of the Tauern Window metamorphic dome (28 +/- 1 Ma) in the Eastern European Alps by using the unprecedented combination of Nd isotopic composition of bulk-rock clay-sized samples and partly previously published multi-proxy (Nd isotopic composition, trace-element geochemistry, U-Pb dating) sand-sized apatite single-grain analysis. The basin offers an excellent opportunity to investigate environmental signal propagation into the sedimentary record because comprehensive stratigraphic and seismic datasets can be combined with present research results. The bulk-rock clay-sized fraction epsilon Nd values of well-cutting samples from one well on the northern basin slope remained stable at similar to-9.7 from 27 to 19 Ma but increased after 19 Ma to similar to-9.1. In contrast, apatite single-grain distributions, which were extracted from 22 drill-core samples, changed significantly around 23.3 Ma from apatites dominantly from low-grade ( Author summary Amoeboid motion is a crawling-like cell migration that plays an important key role in multiple biological processes such as wound healing and cancer metastasis. This type of cell motility results from expanding and simultaneously contracting parts of the cell membrane. From fluorescence images, we obtain a sequence of points, representing the cell membrane, for each time step. By using regression analysis on these sequences, we derive smooth representations, so-called contours, of the membrane. Since the number of measurements is discrete and often limited, the question is raised of how to link consecutive contours with each other. In this work, we present a novel mathematical framework in which these links are described by regularized flows allowing a certain degree of concentration or stretching of neighboring reference points on the same contour. This stretching rate, the so-called local dispersion, is used to identify expansions and contractions of the cell membrane providing a fully automated way of extracting properties of these cell shape changes. We applied our methods to time-lapse microscopy data of the social amoeba Dictyostelium discoideum. Y1 - 2021 U6 - https://doi.org/10.1371/journal.pcbi.1009268 SN - 1553-734X SN - 1553-7358 VL - 17 IS - 8 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Arkes, Hal R. A1 - Aberegg, Scott K. A1 - Arpin, Kevin A. T1 - Analysis of physicians' probability estimates of a medical outcome based on a sequence of events JF - JAMA network open / American Medical Association N2 - IMPORTANCE The probability of a conjunction of 2 independent events is the product of the probabilities of the 2 components and therefore cannot exceed the probability of either component; violation of this basic law is called the conjunction fallacy. A common medical decision-making scenario involves estimating the probability of a final outcome resulting from a sequence of independent events; however, little is known about physicians' ability to accurately estimate the overall probability of success in these situations. OBJECTIVE To ascertain whether physicians are able to correctly estimate the overall probability of a medical outcome resulting from 2 independent events. DESIGN, SETTING, AND PARTICIPANTS This survey study consisted of 3 separate substudies, in which 215 physicians were asked via internet-based survey to estimate the probability of success of each of 2 components of a diagnostic or prognostic sequence as well as the overall probability of success of the 2-step sequence. Substudy 1 was performed from April 2 to 4, 2021, substudy 2 from November 2 toll, 2021, and substudy 3 from May 13 to 19, 2021. All physicians were board certified or board eligible in the primary specialty germane to the substudy (ie, obstetrics and gynecology for substudies land 3 and pulmonology for substudy 2), were recruited from a commercial survey service, and volunteered to participate in the study. EXPOSURES Case scenarios presented in an online survey. MAIN OUTCOMES AND MEASURES Respondents were asked to provide their demographic information in addition to 3 probability estimates. The first substudy included a scenario describing a brow presentation discovered during labor; the 2 conjuncts were the probabilities that the brow presentation would resolve and that the delivery would be vaginal. The second substudy involved a diagnostic evaluation of an incidentally discovered pulmonary nodule; the 2 conjuncts were the probabilities that the patient had a malignant condition and that a technically successful transthoracic needle biopsy would reveal a malignant condition. The third substudy included a modification of the first substudy in an attempt to debias the conjunction fallacy prevalent in the first substudy. Respondents' own probability estimates of the individual events were used to calculate the mathematically correct conjunctive probability. RESULTS Among 215 respondents, the mean (SD) age was 54.0 (9.5) years; 142 respondents (66.0%) were male. Data on race and ethnicity were not collected. A total of 168 physicians (78.1%) estimated the probability of the 2-step sequence to be greater than the probability of at least 1 of the 2 component events. Compared with the product of their 2 estimated components, respondents overestimated the combined probability by 12.8% (95% CI, 9.6%-16.1%; P < .001) in substudy 1, 19.8% (95% Cl, 16.6%-23.0%; P < .001) in substudy 2, and 18.0% (95% CI, 13.4%-22.5%; P < .001) in substudy 3, results that were mathematically incoherent (ie, formally illogical and mathematically incorrect). CONCLUSIONS AND RELEVANCE In this survey study of 215 physicians, respondents consistently overestimated the combined probability of 2 events compared with the probability calculated from their own estimates of the individual events. This biased estimation, consistent with the conjunction fallacy, may have substantial implications for diagnostic and prognostic decision-making. Y1 - 2022 U6 - https://doi.org/10.1001/jamanetworkopen.2022.18804 SN - 2574-3805 VL - 5 IS - 6 PB - American Veterinary Medical Association CY - Chicago ER - TY - JOUR A1 - Schenke, Maren A1 - Schjeide, Brit-Maren A1 - Püschel, Gerhard Paul A1 - Seeger, Bettina T1 - Analysis of motor neurons differentiated from human induced pluripotent stem cells for the use in cell-based Botulinum neurotoxin activity assays JF - Toxins N2 - Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs). For the potency assessment of BoNTs produced for treatment in traditional and aesthetic medicine, the mouse lethality assay is still used by the majority of manufacturers, which is ethically questionable in terms of the 3Rs principle. In this study, MNs were differentiated from human induced pluripotent stem cells based on three published protocols. The resulting cell populations were analyzed for their MN yield and their suitability for the potency assessment of BoNTs. MNs produce specific gangliosides and synaptic proteins, which are bound by BoNTs in order to be taken up by receptor-mediated endocytosis, which is followed by cleavage of specific soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) proteins required for neurotransmitter release. The presence of receptors and substrates for all BoNT serotypes was demonstrated in MNs generated in vitro. In particular, the MN differentiation protocol based on Du et al. yielded high numbers of MNs in a short amount of time with high expression of BoNT receptors and targets. The resulting cells are more sensitive to BoNT/A1 than the commonly used neuroblastoma cell line SiMa. MNs are, therefore, an ideal tool for being combined with already established detection methods. KW - Botulinum neurotoxin KW - motor neurons KW - cell-based in vitro assay KW - potency KW - assessment KW - induced pluripotent stem cells Y1 - 2020 U6 - https://doi.org/10.3390/toxins12050276 SN - 2072-6651 VL - 12 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Milewski, Robert A1 - Chabrillat, Sabine A1 - Behling, Robert T1 - Analyses of Recent Sediment Surface Dynamic of a Namibian Kalahari Salt Pan Based on Multitemporal Landsat and Hyperspectral Hyperion Data JF - Remote Sensing N2 - This study combines spaceborne multitemporal and hyperspectral data to analyze the spatial distribution of surface evaporite minerals and changes in a semi-arid depositional environment associated with episodic flooding events, the Omongwa salt pan (Kalahari, Namibia). The dynamic of the surface crust is evaluated by a change-detection approach using the Iterative-reweighted Multivariate Alteration Detection (IR-MAD) based on the Landsat archive imagery from 1984 to 2015. The results show that the salt pan is a highly dynamic and heterogeneous landform. A change gradient is observed from very stable pan border to a highly dynamic central pan. On the basis of hyperspectral EO-1 Hyperion images, the current distribution of surface evaporite minerals is characterized using Spectral Mixture Analysis (SMA). Assessment of field and image endmembers revealed that the pan surface can be categorized into three major crust types based on diagnostic absorption features and mineralogical ground truth data. The mineralogical crust types are related to different zones of surface change as well as pan morphology that influences brine flow during the pan inundation and desiccation cycles. These combined information are used to spatially map depositional environments where the more dynamic halite crust concentrates in lower areas although stable gypsum and calcite/sepiolite crusts appear in higher elevated areas. KW - salt pan KW - playa KW - hyperspectral KW - multitemporal KW - change detection KW - evaporite minerals Y1 - 2016 U6 - https://doi.org/10.3390/rs9020170 SN - 2072-4292 VL - 9 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Milewski, Robert A1 - Chabrillat, Sabine A1 - Bookhagen, Bodo T1 - Analyses of Namibian Seasonal Salt Pan Crust Dynamics and Climatic Drivers Using Landsat 8 Time-Series and Ground Data JF - Remote Sensing N2 - Salt pans are highly dynamic environments that are difficult to study by in situ methods because of their harsh climatic conditions and large spatial areas. Remote sensing can help to elucidate their environmental dynamics and provide important constraints regarding their sedimentological, mineralogical, and hydrological evolution. This study utilizes spaceborne multitemporal multispectral optical data combined with spectral endmembers to document spatial distribution of surface crust types over time on the Omongwa pan located in the Namibian Kalahari. For this purpose, 49 surface samples were collected for spectral and mineralogical characterization during three field campaigns (2014–2016) reflecting different seasons and surface conditions of the salt pan. An approach was developed to allow the spatiotemporal analysis of the salt pan crust dynamics in a dense time-series consisting of 77 Landsat 8 cloud-free scenes between 2014 and 2017, covering at least three major wet–dry cycles. The established spectral analysis technique Sequential Maximum Angle Convex Cone (SMACC) extraction method was used to derive image endmembers from the Landsat time-series stack. Evaluation of the extracted endmember set revealed that the multispectral data allowed the differentiation of four endmembers associated with mineralogical mixtures of the crust’s composition in dry conditions and three endmembers associated with flooded or muddy pan conditions. The dry crust endmember spectra have been identified in relation to visible, near infrared, and short-wave infrared (VNIR–SWIR) spectroscopy and X-ray diffraction (XRD) analyses of the collected surface samples. According these results, the spectral endmembers are interpreted as efflorescent halite crust, mixed halite–gypsum crust, mixed calcite quartz sepiolite crust, and gypsum crust. For each Landsat scene the spatial distribution of these crust types was mapped with the Spectral Angle Mapper (SAM) method and significant spatiotemporal dynamics of the major surface crust types were observed. Further, the surface crust dynamics were analyzed in comparison with the pan’s moisture regime and other climatic parameters. The results show that the crust dynamics are mainly driven by flooding events in the wet season, but are also influenced by temperature and aeolian activity in the dry season. The approach utilized in this study combines the advantages of multitemporal satellite data for temporal event characterization with advantages from hyperspectral methods for the image and ground data analyses that allow improved mineralogical differentiation and characterization. KW - salt pan KW - playa KW - spectral analysis KW - crust KW - saline pan cycle KW - evaporites KW - time-series mapping Y1 - 2019 U6 - https://doi.org/10.3390/rs12030474 SN - 2072-4292 IS - 3 PB - MDPI CY - Basel ER - TY - GEN A1 - Degen, Andreas T1 - Analyse visueller Wahrnehmungsqualitäten von Lyrik T2 - Textpraxis : digitales Journal für Philologie / Sonderausgabe N2 - Das Projekt beschäftigt sich mit der visuellen Wirkungsdimension von Lyrik und der Möglichkeit ihrer analytischen Beschreibung. Dafür werden die Anordnung von Versen und Wörtern, Auszeichnungen und andere typographische Strukturen von nicht experimentellen Gedichten seit Ende des 18. Jahrhunderts im Rahmen von Modellanalysen untersucht. Y1 - 2023 UR - https://www.textpraxis.net/andreas-degen-visuelle-wahrnehmungsqualitaeten U6 - https://doi.org/10.17879/19958489288 SN - 2191-8236 VL - 7 IS - 2 PB - Westfälische Wilhelms-Universität CY - Münster ER - TY - JOUR A1 - Thomas, Jessica E. A1 - Carvalho, Gary R. A1 - Haile, James A1 - Martin, Michael D. A1 - Castruita, Jose A. Samaniego A1 - Niemann, Jonas A1 - Sinding, Mikkel-Holger S. A1 - Sandoval-Velasco, Marcela A1 - Rawlence, Nicolas J. A1 - Fuller, Errol A1 - Fjeldsa, Jon A1 - Hofreiter, Michael A1 - Stewart, John R. A1 - Gilbert, M. Thomas P. A1 - Knapp, Michael T1 - An ‛Aukward’ tale BT - a genetic approach to discover the whereabouts of the Last Great Auks JF - Genes N2 - One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller’s candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars’ minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds. KW - ancient DNA KW - extinct birds KW - mitochondrial genome KW - museum specimens KW - palaeogenomics Y1 - 2017 U6 - https://doi.org/10.3390/genes8060164 SN - 2073-4425 VL - 8 IS - 6 SP - 164 PB - MDPI CY - Basel ER - TY - JOUR A1 - Qin, Xia A1 - Faaß, Marcel A1 - Niedermeier, Frank T1 - An Overview of the ‘National Multiplication Trainings’ Programme JF - Potsdamer Beiträge zur Hochschulforschung N2 - The article introduces the efforts exerted to initiate multiplication of the DIES training courses to a wider audience of higher education managers and academics in the target regions. The DIES ‘National Multiplication Trainings’ Programme has supported three cohorts of alumni teams so far to implement national training courses in the area of higher education leadership and management. The article sets the context of this publication and reflects on the main evaluation results of the programme implementation itself. KW - training multiplication KW - higher education management KW - higher education leadership KW - capacity building KW - alumni work Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-493344 SN - 978-3-86956-496-8 SN - 2192-1075 SN - 2192-1083 IS - 5 SP - 17 EP - 35 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - He, Hai A1 - Höper, Rune A1 - Dodenhöft, Moritz A1 - Marlière, Philippe A1 - Bar-Even, Arren T1 - An optimized methanol assimilation pathway relying on promiscuous formaldehyde-condensing aldolases in E. coli JF - Metabolic Engineering N2 - Engineering biotechnological microorganisms to use methanol as a feedstock for bioproduction is a major goal for the synthetic metabolism community. Here, we aim to redesign the natural serine cycle for implementation in E. coli. We propose the homoserine cycle, relying on two promiscuous formaldehyde aldolase reactions, as a superior pathway design. The homoserine cycle is expected to outperform the serine cycle and its variants with respect to biomass yield, thermodynamic favorability, and integration with host endogenous metabolism. Even as compared to the RuMP cycle, the most efficient naturally occurring methanol assimilation route, the homoserine cycle is expected to support higher yields of a wide array of products. We test the in vivo feasibility of the homoserine cycle by constructing several E. coli gene deletion strains whose growth is coupled to the activity of different pathway segments. Using this approach, we demonstrate that all required promiscuous enzymes are active enough to enable growth of the auxotrophic strains. Our findings thus identify a novel metabolic solution that opens the way to an optimized methylotrophic platform. KW - Pathway design KW - Promiscuous enzymes KW - Formaldehyde assimilation KW - Serine cycle KW - Growth selection Y1 - 2020 U6 - https://doi.org/10.1016/j.ymben.2020.03.002 SN - 1096-7176 SN - 1096-7184 VL - 60 SP - 1 EP - 13 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - BOOK A1 - Baltzer, Wanda A1 - Hradilak, Theresa A1 - Pfennigschmidt, Lara A1 - Prestin, Luc Maurice A1 - Spranger, Moritz A1 - Stadlinger, Simon A1 - Wendt, Leo A1 - Lincke, Jens A1 - Rein, Patrick A1 - Church, Luke A1 - Hirschfeld, Robert T1 - An individual-centered approach to visualize people’s opinions and demographic information N2 - The noble way to substantiate decisions that affect many people is to ask these people for their opinions. For governments that run whole countries, this means asking all citizens for their views to consider their situations and needs. Organizations such as Africa's Voices Foundation, who want to facilitate communication between decision-makers and citizens of a country, have difficulty mediating between these groups. To enable understanding, statements need to be summarized and visualized. Accomplishing these goals in a way that does justice to the citizens' voices and situations proves challenging. Standard charts do not help this cause as they fail to create empathy for the people behind their graphical abstractions. Furthermore, these charts do not create trust in the data they are representing as there is no way to see or navigate back to the underlying code and the original data. To fulfill these functions, visualizations would highly benefit from interactions to explore the displayed data, which standard charts often only limitedly provide. To help improve the understanding of people's voices, we developed and categorized 80 ideas for new visualizations, new interactions, and better connections between different charts, which we present in this report. From those ideas, we implemented 10 prototypes and two systems that integrate different visualizations. We show that this integration allows consistent appearance and behavior of visualizations. The visualizations all share the same main concept: representing each individual with a single dot. To realize this idea, we discuss technologies that efficiently allow the rendering of a large number of these dots. With these visualizations, direct interactions with representations of individuals are achievable by clicking on them or by dragging a selection around them. This direct interaction is only possible with a bidirectional connection from the visualization to the data it displays. We discuss different strategies for bidirectional mappings and the trade-offs involved. Having unified behavior across visualizations enhances exploration. For our prototypes, that includes grouping, filtering, highlighting, and coloring of dots. Our prototyping work was enabled by the development environment Lively4. We explain which parts of Lively4 facilitated our prototyping process. Finally, we evaluate our approach to domain problems and our developed visualization concepts. Our work provides inspiration and a starting point for visualization development in this domain. Our visualizations can improve communication between citizens and their government and motivate empathetic decisions. Our approach, combining low-level entities to create visualizations, provides value to an explorative and empathetic workflow. We show that the design space for visualizing this kind of data has a lot of potential and that it is possible to combine qualitative and quantitative approaches to data analysis. N2 - Der noble Weg, Entscheidungen, die viele Menschen betreffen, zu begründen, besteht darin, diese Menschen nach ihrer Meinung zu fragen. Für Regierungen, die ganze Länder führen, bedeutet dies, alle Bürger nach ihrer Meinung zu fragen, um ihre Situationen und Bedürfnisse zu berücksichtigen. Organisationen wie die Africa's Voices Foundation, die die Kommunikation zwischen Entscheidungsträgern und Bürgern eines Landes erleichtern wollen, haben Schwierigkeiten, zwischen diesen Gruppen zu vermitteln. Um Verständnis zu ermöglichen, müssen die Aussagen zusammengefasst und visualisiert werden. Diese Ziele auf eine Weise zu erreichen, die den Stimmen und Situationen der Bürgerinnen und Bürger gerecht wird, erweist sich als Herausforderung. Standardgrafiken helfen dabei nicht weiter, da es ihnen nicht gelingt, Empathie für die Menschen hinter ihren grafischen Abstraktionen zu schaffen. Darüber hinaus schaffen diese Diagramme kein Vertrauen in die Daten, die sie darstellen, da es keine Möglichkeit gibt, den verwendeten Code und die Originaldaten zu sehen oder zu ihnen zurück zu navigieren. Um diese Funktionen zu erfüllen, würden Visualisierungen sehr von Interaktionen zur Erkundung der angezeigten Daten profitieren, die Standardgrafiken oft nur begrenzt bieten. Um das Verständnis der Stimmen der Menschen zu verbessern, haben wir 80 Ideen für neue Visualisierungen, neue Interaktionen und bessere Verbindungen zwischen verschiedenen Diagrammen entwickelt und kategorisiert, die wir in diesem Bericht vorstellen. Aus diesen Ideen haben wir 10 Prototypen und zwei Systeme implementiert, die verschiedene Visualisierungen integrieren. Wir zeigen, dass diese Integration ein einheitliches Erscheinungsbild und Verhalten der Visualisierungen ermöglicht. Die Visualisierungen haben alle das gleiche Grundkonzept: Jedes Individuum wird durch einen einzigen Punkt dargestellt. Um diese Idee zu verwirklichen, diskutieren wir Technologien, die die effiziente Darstellung einer großen Anzahl dieser Punkte ermöglichen. Mit diesen Visualisierungen sind direkte Interaktionen mit Darstellungen von Individuen möglich, indem man auf sie klickt oder eine Auswahl um sie herumzieht. Diese direkte Interaktion ist nur mit einer bidirektionalen Verbindung von der Visualisierung zu den angezeigten Daten möglich. Wir diskutieren verschiedene Strategien für bidirektionale Mappings und die damit verbundenen Kompromisse. Ein einheitliches Verhalten über Visualisierungen hinweg verbessert die Exploration. Für unsere Prototypen umfasst dies Gruppierung, Filterung, Hervorhebung und Einfärbung von Punkten. Unsere Arbeit an den Prototypen wurde durch die Entwicklungsumgebung Lively4 ermöglicht. Wir erklären, welche Teile von Lively4 unseren Prototyping-Prozess erleichtert haben. Schließlich bewerten wir unsere Herangehensweise an Domänenprobleme und die von uns entwickelten Visualisierungskonzepte. Unsere Arbeit liefert Inspiration und einen Ausgangspunkt für die Entwicklung von Visualisierungen in diesem Bereich. Unsere Visualisierungen können die Kommunikation zwischen Bürgern und ihrer Regierung verbessern und einfühlsame Entscheidungen motivieren. Unser Ansatz, bei dem wir niedrigstufige Entitäten zur Erstellung von Visualisierungen kombinieren, bietet einen wertvollen Ansatz für einen explorativen und einfühlsamen Arbeitsablauf. Wir zeigen, dass der Designraum für die Visualisierung dieser Art von Daten ein großes Potenzial hat und dass es möglich ist, qualitative und quantitative Ansätze zur Datenanalyse zu kombinieren. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 136 KW - data visualization KW - demographic information KW - visualization concept exploration KW - web-based development environment KW - Datenvisualisierung KW - demografische Informationen KW - Visualisierungskonzept-Exploration KW - web-basierte Entwicklungsumgebung Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-491457 SN - 978-3-86956-504-0 SN - 1613-5652 SN - 2191-1665 IS - 136 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hoan, Tran Viet A1 - Richter, Karl-Gerd A1 - Borsig, Nicolas A1 - Bauer, Jonas A1 - Ha, Nguyen Thi A1 - Norra, Stefan T1 - An improved groundwater model framework for aquifer structures of the quaternary-formed sediment body in the southernmost parts of the Mekong Delta, Vietnam JF - Hydrology : open access journal N2 - The Ca Mau peninsula (CMP) is a key economic region in southern Vietnam. In recent decades, the high demand for water has increased the exploitation of groundwater, thus lowering the groundwater level and leading to risks of degradation, depletion, and land subsidence, as well as salinity intrusion in the groundwater of the whole Mekong Delta region. By using a finite element groundwater model with boundary expansion to the sea, we updated the latest data on hydrogeological profiles, groundwater levels, and exploitation. The basic model setup covers seven aquifers and seven aquitards. It is determined that the inflow along the coastline to the mainland is 39% of the total inflow. The exploitation of the study area in 2019 was 567,364 m(3)/day. The most exploited aquifers are the upper-middle Pleistocene (qp(2-3)) and the middle Pliocene (n(2)(2)), accounting for 63.7% and 24.6%, respectively; the least exploited aquifers are the upper Pleistocene and the upper Miocene, accounting for 0.35% and 0.02%, respectively. In the deeper aquifers, qp(2-3) and n(2)(2), the change in storage is negative due to the high exploitation rate, leading to a decline in the reserves of these aquifers. These groundwater model results are the calculations of groundwater reserves from the coast to the mainland in the entire system of aquifers in the CMP. This makes groundwater decision managers, stakeholders, and others more efficient in sustainable water resources planning in the CMP and Mekong Delta (MKD). KW - groundwater modeling KW - hydrogeology KW - aquifers system KW - water balance; KW - validation of model KW - Ca Mau peninsula KW - Kien Giang KW - Soc Trang KW - Hau Giang KW - Bac Lieu Y1 - 2022 U6 - https://doi.org/10.3390/hydrology9040061 SN - 2306-5338 VL - 9 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Nakoudi, Konstantina A1 - Stachlewska, Iwona S. A1 - Ritter, Christoph T1 - An extended lidar-based cirrus cloud retrieval scheme BT - first application over an Arctic site JF - Optics express : the international electronic journal of optics / Optica N2 - Accurate and precise characterization of cirrus cloud geometrical and optical properties is essential for better constraining their radiative footprint. A lidar-based retrieval scheme is proposed here, with its performance assessed on fine spatio-temporal observations over the Arctic site of Ny-Alesund, Svalbard. Two contributions related to cirrus geometrical (dynamic Wavelet Covariance Transform (WCT)) and optical properties (constrained Klett) are reported. The dynamic WCT rendered cirrus detection more robust, especially for thin cirrus layers that frequently remained undetected by the classical WCT method. Regarding optical characterization, we developed an iterative scheme for determining the cirrus lidar ratio (LRci) that is a crucial parameter for aerosol - cloud discrimination. Building upon the Klett-Fernald method, the LRci was constrained by an additional reference value. In established methods, such as the double-ended Klett, an aerosol-free reference value is applied. In the proposed constrained Klett, however, the reference value was approximated from cloud-free or low cloud optical depth (COD up to 0.2) profiles and proved to agree with independent Raman estimates. For optically thin cirrus, the constrained Klett inherent uncertainties reached 50% (60-74%) in terms of COD (LRci). However, for opaque cirrus COD (LRci) uncertainties were lower than 10% (15%). The detection method discrepancies (dynamic versus static WCT) had a higher impact on the optical properties of low COD layers (up to 90%) compared to optically thicker ones (less than 10%). The constrained Klett presented high agreement with two established retrievals. For an exemplary cirrus cloud, the constrained Klett estimated the COD355 (LRci355) at 0.28 +/- 0.17 (29 +/- 4 sr), the double-ended Klett at 0.27 +/- 0.15 (32 +/- 4 sr) and the Raman retrievals at 0.22 +/- 0.12 (26 +/- 11 sr). Our approach to determine the necessary reference value can also be applied in established methods and increase their accuracy. In contrast, the classical aerosol-free assumption led to 44 sr LRci overestimation in optically thin layers and 2-8 sr in thicker ones. The multiple scattering effect was corrected using Eloranta (1998) and accounted for 50-60% extinction underestimation near the cloud base and 20-30% within the cirrus layers. Y1 - 2021 U6 - https://doi.org/10.1364/OE.414770 SN - 1094-4087 VL - 29 IS - 6 SP - 8553 EP - 8580 PB - Optical Society of America CY - Washington ER - TY - JOUR A1 - Warschburger, Petra A1 - Wortmann, Hanna Rosalie A1 - Gisch, Ulrike Alexandra A1 - Baer, Nadja-Raphaela A1 - Schenk, Liane A1 - Anton, Verena A1 - Bergmann, Manuela M. T1 - An experimental approach to training interoceptive sensitivity BT - study protocol for a pilot randomized controlled trial JF - Nutrition Journal N2 - Background Eating in absence of hunger is quite common and often associated with an increased energy intake co-existent with a poorer food choice. Intuitive eating (IE), i.e., eating in accordance with internal hunger and satiety cues, may protect from overeating. IE, however, requires accurate perception and processing of one’s own bodily signals, also referred to as interoceptive sensitivity. Training interoceptive sensitivity might therefore be an effective method to promote IE and prevent overeating. As most studies on eating behavior are conducted in younger adults and close social relationships influence health-related behavior, this study focuses on middle-aged and older couples. Methods The present pilot randomized intervention study aims at investigating the feasibility and effectiveness of a 21-day mindfulness-based training program designed to increase interoceptive sensitivity. A total of N = 60 couples participating in the NutriAct Family Study, aged 50–80 years, will be recruited. This randomized-controlled intervention study comprises three measurement points (pre-intervention, post-intervention, 4-week follow-up) and a 21-day training that consists of daily mindfulness-based guided audio exercises (e.g., body scan). A three-arm intervention study design is applied to compare two intervention groups (training together as a couple vs. training alone) with a control group (no training). Each measurement point includes the assessment of self-reported and objective indicators of interoceptive sensitivity (primary outcome), self-reported indicators of intuitive and maladaptive eating (secondary outcomes), and additional variables. A training evaluation applying focus group discussions will be conducted to assess participants’ overall acceptance of the training and its feasibility. Discussion By investigating the feasibility and effectiveness of a mindfulness-based training program to increase interoceptive sensitivity, the present study will contribute to a deeper understanding of how to promote healthy eating in older age. KW - Digital intervention KW - Older adults KW - Interoception KW - Eating behavior KW - Intuitive eating KW - Partnership KW - Mindfulness KW - Randomized-controlled trial KW - NutriAct Family Study KW - Mixed methods Y1 - 2022 U6 - https://doi.org/10.1186/s12937-022-00827-4 SN - 1475-2891 VL - 21 PB - Springer Nature CY - London ER - TY - JOUR A1 - Concia, Francesca A1 - Distler, Petr A1 - Law, Gareth A1 - Macerata, Elena A1 - Mariani, Mario A1 - Mossini, Eros A1 - Negrin, Maddalena A1 - Štrok, Marko ED - Meinel, Christoph ED - Schweiger, Stefanie ED - Staubitz, Thomas ED - Conrad, Robert ED - Alario Hoyos, Carlos ED - Ebner, Martin ED - Sancassani, Susanna ED - Żur, Agnieszka ED - Friedl, Christian ED - Halawa, Sherif ED - Gamage, Dilrukshi ED - Scott, Jeffrey ED - Kristine Jonson Carlon, May ED - Deville, Yves ED - Gaebel, Michael ED - Delgado Kloos, Carlos ED - von Schmieden, Karen T1 - An experience in developing models to use MOOCs in teaching and to advocate OERs JF - EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash? N2 - Loss of expertise in the fields of Nuclear- and Radio-Chemistry (NRC) is problematic at a scientific and social level. This has been addressed by developing a MOOC, in order to let students in scientific matters discover all the benefits of NRC to society and improving their awareness of this discipline. The MOOC “Essential Radiochemistry for Society” includes current societal challenges related to health, clean and sustainable energy for safety and quality of food and agriculture. NRC teachers belonging to CINCH network were invited to use the MOOC in their teaching, according to various usage models: on the basis of these different experiences, some usage patterns were designed, describing context characteristics (number and age of students, course), activities’ scheduling and organization, results and students’ feedback, with the aim of encouraging the use of MOOCs in university teaching, as an opportunity for both lecturers and students. These models were the basis of a “toolkit for teachers”. By experiencing digital teaching resources created by different lecturers, CINCH teachers took a first meaningful step towards understanding the worth of Open Educational Resources (OER) and the importance of their creation, adoption and sharing for knowledge progress. In this paper, the entire path from MOOC concept to MOOC different usage models, to awareness-raising regarding OER is traced in conceptual stages. KW - Digitale Bildung KW - Kursdesign KW - MOOC KW - Micro Degree KW - Online-Lehre KW - Onlinekurs KW - Onlinekurs-Produktion KW - digital education KW - e-learning KW - micro degree KW - micro-credential KW - online course creation KW - online course design KW - online teaching Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-624609 SP - 239 EP - 254 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Jararnezhadgero, AmirAli A1 - Mamashli, Elaheh A1 - Granacher, Urs T1 - An Endurance-Dominated Exercise Program Improves Maximum Oxygen Consumption, Ground Reaction Forces, and Muscle Activities in Patients With Moderate Diabetic Neuropathy JF - Frontiers in physiology / Frontiers Research Foundation N2 - Background: The prevalence of diabetes worldwide is predicted to increase from 2.8% in 2000 to 4.4% in 2030. Diabetic neuropathy (DN) is associated with damage to nerve glial cells, their axons, and endothelial cells leading to impaired function and mobility. Objective: We aimed to examine the effects of an endurance-dominated exercise program on maximum oxygen consumption (VO2max), ground reaction forces, and muscle activities during walking in patients with moderate DN. Methods: Sixty male and female individuals aged 45–65 years with DN were randomly assigned to an intervention (IG, n = 30) or a waiting control (CON, n = 30) group. The research protocol of this study was registered with the Local Clinical Trial Organization (IRCT20200201046326N1). IG conducted an endurance-dominated exercise program including exercises on a bike ergometer and gait therapy. The progressive intervention program lasted 12 weeks with three sessions per week, each 40–55 min. CON received the same treatment as IG after the post-tests. Pre- and post-training, VO2max was tested during a graded exercise test using spiroergometry. In addition, ground reaction forces and lower limbs muscle activities were recorded while walking at a constant speed of ∼1 m/s. Results: No statistically significant baseline between group differences was observed for all analyzed variables. Significant group-by-time interactions were found for VO2max (p < 0.001; d = 1.22). The post-hoc test revealed a significant increase in IG (p < 0.001; d = 1.88) but not CON. Significant group-by-time interactions were observed for peak lateral and vertical ground reaction forces during heel contact and peak vertical ground reaction force during push-off (p = 0.001–0.037; d = 0.56–1.53). For IG, post-hoc analyses showed decreases in peak lateral (p < 0.001; d = 1.33) and vertical (p = 0.004; d = 0.55) ground reaction forces during heel contact and increases in peak vertical ground reaction force during push-off (p < 0.001; d = 0.92). In terms of muscle activity, significant group-by-time interactions were found for vastus lateralis and gluteus medius during the loading phase and for vastus medialis during the mid-stance phase, and gastrocnemius medialis during the push-off phase (p = 0.001–0.044; d = 0.54–0.81). Post-hoc tests indicated significant intervention-related increases in vastus lateralis (p = 0.001; d = 1.08) and gluteus medius (p = 0.008; d = 0.67) during the loading phase and vastus medialis activity during mid-stance (p = 0.001; d = 0.86). In addition, post-hoc tests showed decreases in gastrocnemius medialis during the push-off phase in IG only (p < 0.001; d = 1.28). Conclusions: This study demonstrated that an endurance-dominated exercise program has the potential to improve VO2max and diabetes-related abnormal gait in patients with DN. The observed decreases in peak vertical ground reaction force during the heel contact of walking could be due to increased vastus lateralis and gluteus medius activities during the loading phase. Accordingly, we recommend to implement endurance-dominated exercise programs in type 2 diabetic patients because it is feasible, safe and effective by improving aerobic capacity and gait characteristics. KW - oxygen consumption KW - kinetics KW - electromyography KW - diabetic KW - gait Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.654755 SN - 1664-042X VL - 12 SP - 1 EP - 15 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Musculus, Lisa A1 - Tünte, Markus R. A1 - Raab, Markus A1 - Kayhan, Ezgi T1 - An Embodied Cognition Perspective on the Role of Interoception in the Development of the Minimal Self JF - Frontiers in Psychology N2 - Interoception is an often neglected but crucial aspect of the human minimal self. In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans. To do so, we first provide a comparative overview of the central accounts addressing the link between interoception and the minimal self. Grounding our arguments on the embodiment framework, we propose a bidirectional relationship between motor and interoceptive states, which jointly contribute to the development of the minimal self. We present empirical findings on interoception in development and discuss the role of interoception in the development of the minimal self. Moreover, we make theoretical predictions that can be tested in future experiments. Our goal is to provide a comprehensive view on the mechanisms underlying the minimal self by explaining the role of interoception in the development of the minimal self. KW - interoception KW - development of minimal self KW - cardioception KW - embodied cognition KW - bodily self Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.716950 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Ciemer, Catrin A1 - Rehm, Lars A1 - Kurths, Jürgen A1 - Donner, Reik Volker A1 - Winkelmann, Ricarda A1 - Boers, Niklas T1 - An early-warning indicator for Amazon droughts exclusively based on tropical Atlantic sea surface temperatures JF - Environmental Research Letters N2 - Droughts in tropical South America have an imminent and severe impact on the Amazon rainforest and affect the livelihoods of millions of people. Extremely dry conditions in Amazonia have been previously linked to sea surface temperature (SST) anomalies in the adjacent tropical oceans. Although the sources and impacts of such droughts have been widely studied, establishing reliable multi-year lead statistical forecasts of their occurrence is still an ongoing challenge. Here, we further investigate the relationship between SST and rainfall anomalies using a complex network approach. We identify four ocean regions which exhibit the strongest overall SST correlations with central Amazon rainfall, including two particularly prominent regions in the northern and southern tropical Atlantic. Based on the time-dependent correlation between SST anomalies in these two regions alone, we establish a new early-warning method for droughts in the central Amazon basin and demonstrate its robustness in hindcasting past major drought events with lead-times up to 18 months. KW - complex networks KW - droughts KW - prediction KW - Amazon rainforest Y1 - 2019 VL - 15 IS - 9 PB - IOP - Institute of Physics Publishing CY - Bristol ER - TY - JOUR A1 - Haugsbakken, Halvdan A1 - Hagelia, Marianne ED - Meinel, Christoph ED - Schweiger, Stefanie ED - Staubitz, Thomas ED - Conrad, Robert ED - Alario Hoyos, Carlos ED - Ebner, Martin ED - Sancassani, Susanna ED - Żur, Agnieszka ED - Friedl, Christian ED - Halawa, Sherif ED - Gamage, Dilrukshi ED - Scott, Jeffrey ED - Kristine Jonson Carlon, May ED - Deville, Yves ED - Gaebel, Michael ED - Delgado Kloos, Carlos ED - von Schmieden, Karen T1 - An asynchronous cooperative leaning design in a Small Private Online Course (SPOC) JF - EMOOCs 2023 : Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash? N2 - This short paper sets out to propose a novel and interesting learning design that facilitates for cooperative learning in which students do not conduct traditional group work in an asynchronous online education setting. This learning design will be explored in a Small Private Online Course (SPOC) among teachers and school managers at a teacher education. Such an approach can be made possible by applying specific criteria commonly used to define collaborative learning. Collaboration can be defined, among other things, as a structured way of working among students that includes elements of co-laboring. The cooperative learning design involves adapting various traditional collaborative learning approaches for use in an online learning environment. A critical component of this learning design is that students work on a self-defined case project related to their professional practices. Through an iterative process, students will receive ongoing feedback and formative assessments from instructors and follow students at specific points, meaning that co-constructing of knowledge and learning takes place as the SPOC progresses. This learning design can contribute to better learning experiences and outcomes for students, and be a valuable contribution to current research discussions on learning design in Massive Open Online Courses (MOOCs). KW - Digitale Bildung KW - Kursdesign KW - MOOC KW - Micro Degree KW - Online-Lehre KW - Onlinekurs KW - Onlinekurs-Produktion KW - digital education KW - e-learning KW - micro degree KW - micro-credential KW - online course creation KW - online course design KW - online teaching Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-622107 SP - 67 EP - 76 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Dreher, Dorothee A1 - Baldermann, Susanne A1 - Schreiner, Monika A1 - Hause, Bettina T1 - An arbuscular mycorrhizal fungus and a root pathogen induce different volatiles emitted by Medicago truncatula roots JF - Journal of Advanced Research N2 - Plants are in permanent contact with various microorganisms and are always impacted by them. To better understand the first steps of a plant’s recognition of soil-borne microorganisms, the early release of volatile organic compounds (VOCs) emitted from roots of Medicago truncatula in response to the symbiont Rhizophagus irregularis or the pathogenic oomycete Aphanomyces euteiches was analysed. More than 90 compounds were released from roots as detected by an untargeted gas chromatography-mass spectrometry approach. Principal component analyses clearly distinguished untreated roots from roots treated with either R. irregularis or A. euteiches. Several VOCs were found to be emitted specifically in response to each of the microorganisms. Limonene was specifically emitted from wild-type roots after contact with R. irregularis spores but not from roots of the mycorrhiza-deficient mutant does not make infections3. The application of limonene to mycorrhizal roots, however, did not affect the mycorrhization rate. Inoculation of roots with A. euteiches zoospores resulted in the specific emission of several sesquiterpenes, such as nerolidol, viridiflorol and nerolidol-epoxyacetate but application of nerolidol to zoospores of A. euteiches did not affect their vitality. Therefore, plants discriminate between different microorganisms at early stages of their interaction and respond differently to the level of root-emitted volatiles. KW - Arbuscular mycorrhiza KW - Oomycetous pathogen KW - Volatile organic compound (VOC) KW - Aeroponic cultivation KW - Gas chromatography-mass spectrometry (GC-MS) Y1 - 2019 U6 - https://doi.org/10.1016/j.jare.2019.03.002 SN - 2090-1232 SN - 2090-1224 VL - 19 SP - 85 EP - 90 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Uličná, Lenka ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Amulets Found in Bohemian Genizot BT - a first approach KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Franconia KW - Landesgeschichte KW - Ländliches Judentum KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470952 SN - 978-3-86956-470-8 SP - 69 EP - 80 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Aloni, Sapir Shekef A1 - Perovic, Milena A1 - Weitman, Michal A1 - Cohen, Reut A1 - Oschatz, Martin A1 - Mastai, Yitzhak T1 - Amino acid-based ionic liquids as precursors for the synthesis of chiral nanoporous carbons JF - Nanoscale Advances N2 - The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces. Y1 - 2019 U6 - https://doi.org/10.1039/c9na00520j SN - 2516-0230 VL - 1 IS - 12 SP - 4981 EP - 4988 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Naolou, Toufik A1 - Lendlein, Andreas A1 - Neffe, Axel T. T1 - Amides as non-polymerizable catalytic adjuncts enable the ring-opening polymerization of lactide with ferrous acetate under mild conditions JF - Frontiers in Chemistry N2 - Sn-based catalysts are effective in the ring-opening polymerization (ROP) but are toxic. Fe(OAc)(2) used as an alternative catalyst is suitable for the ROP of lactide only at higher temperatures (>170 degrees C), associated with racemization. In the ROP of ester and amide group containing morpholinediones with Fe(OAc)(2) to polydepsipeptides at 135 degrees C, ester bonds were selectively opened. Here, it was hypothesized that ROP of lactones is possible with Fe(OAc)(2) when amides are present in the reactions mixture as Fe-ligands could increase the solubility and activity of the metal catalytic center. The ROP of lactide in the melt with Fe(OAc)(2) is possible at temperatures as low as 105 degrees C, in the presence of N-ethylacetamide or N-rnethylbenzamide as non-polymerizable catalytic adjuncts (NPCA), with high conversion (up to 99 mol%) and yield (up to 88 mol%). Polydispersities of polylactide decreased with decreasing reaction temperature to <= 1.1. NMR as well as polarimetric studies showed that no racemization occurred at reaction temperatures <= 145 degrees C. A kinetic study demonstrated a living chain-growth mechanism. MALDI analysis revealed that no side reactions (e.g., cyclization) occurred, though transesterification took place. KW - ring-opening polymerization KW - polyester KW - catalyst KW - iron KW - amide ligand Y1 - 2019 U6 - https://doi.org/10.3389/fchem.2019.00346 SN - 2296-2646 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Schwartz, Yitzchak T1 - American Jewish Ideas in a Transnational Jewish World, 1843–1900 JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien N2 - As mid-19th-century American Jews introduced radical changes to their religious observance and began to define Judaism in new ways, to what extent did they engage with European Jewish ideas? Historians often approach religious change among Jews from German lands during this period as if Jewish immigrants had come to America with one set of ideas that then evolved solely in conversation with their American contexts. Historians have similarly cast the kinds of Judaism Americans created as both unique to America and uniquely American. These characterizations are accurate to an extent. But to what extent did Jewish innovations in the United States take place in conversation with European Jewish developments? Looking to the 19th-century American Jewish press, this paper seeks to understand how American Jews engaged European Judaism in formulating their own ideas, understanding themselves, and understanding their place in world Judaism. KW - modern Jewish history KW - Orthodox Judaism KW - Reform Judaism KW - Isaac Leeser KW - Isaac Mayer Wise KW - print culture KW - 19th century KW - German Jewry KW - United States KW - moderne jüdische Geschichte KW - jüdische Orthodoxie KW - Reformjudentum KW - Isaac Leeser KW - Isaac Mayer Wise KW - 19. Jahrhundert KW - deutsch-jüdische Geschichte KW - USA Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532835 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 39 EP - 52 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Lange, Bastian A1 - Bürkner, Hans-Joachim T1 - Ambiguous avant-gardes and their geographies BT - on blank spots of the postgrowth debate JF - Die Erde : journal of the Geographical Society of Berlin ; Zeitschrift der Gesellschaft für Erdkunde zu Berlin N2 - In the following article, the focus is on the transformative potentials created by so-called persistence avant-gardes and prevention innovators. The text extends Bluhdorn's guiding concept of narratives of hope (Bluhdorn 2017; Bluhdorn and Butzlaff 2019) by considering those groups that are marginalized within debates on socio-ecological transformation. With a closer look at the narratives of prevention and blockade that these actors engage, the ambiguous nature of postgrowth avant-gardes is carved out. Their discursive, argumentative, and effective inhibition of transitory policies is interpreted as a pro-active potential, rather than a mere obstacle to socio-ecological transformation. Adding a geographical perspective, the paper pleads for a more precise theoretical penetration of the ambivalent figure of avantgardes when analyzing processes of local and regional postgrowth. N2 - Mit dem Beitrag richten wir den Fokus auf transformative Potenziale, die von sogenannten Beharrungsavantgar-den und Präventionsinnovatoren ausgehen. Der Text erweitert Blühdorns Leitkonzept der Hoffnungsnarrative (Blühdorn 2017; Blühdorn and Butzlaff 2019), indem er jene Gruppen in den Blick nimmt, die in den Debatten um die sozial-ökologische Transformation marginalisiert werden. Mit einem genaueren Blick auf die Präventions- und Blockade-Narrative dieser Akteure wird die Mehrdeutigkeit der Postwachstumsavantgarden herausgear-beitet. Ihre diskursive, argumentative und effektive Verhinderung transitorischer Politiken wird als proaktives Potenzial und nicht als bloßes Hindernis für eine sozial-ökologische Transformation interpretiert. Unter Hinzu-nahme einer geographischen Perspektive plädiert der Beitrag für eine präzisere theoretische Durchdringung der ambivalenten Figur der Avantgarden bei der Analyse lokaler und regionaler Postwachstumsvorgänge. KW - alternative economies KW - transformative policies KW - change agents KW - postgrowth KW - regional development KW - East Germany Y1 - 2021 U6 - https://doi.org/10.12854/erde-2021-566 SN - 0013-9998 VL - 152 IS - 4 SP - 273 EP - 287 PB - Gesellschaft für Erdkunde CY - Berlin ER - TY - JOUR A1 - Weiss, Irene M. ED - Ambühl, Annemarie T1 - Amarilis y la belleza de Zacinto BT - voces de poetas en el idilio 4 de Teócrito JF - thersites 11: tessellae – Birthday Issue for Christine Walde N2 - Theocritus’ id. 4 has been considered by some scholars as an example of rural mime; the fact that the poem, a unique case in the Corpus Theocriteum, does not contain any pastoral song or contest contributes to the impression of ‘realism’. This lack could be an obstacle for the poetological approach to the bucolic genre in antiquity, which considers metapoetry as its main feature. Our reading of the idyll shows that this limitation is only apparent. KW - Theocritus KW - bucolic genre KW - metapoetry KW - intertextuality KW - Aristophanes Y1 - 2020 U6 - https://doi.org/10.34679/thersites.vol11.174 SN - 2364-7612 VL - 2020 IS - 11 SP - 1 EP - 30 ER - TY - JOUR A1 - Schröter, David A1 - Neugart, Susanne A1 - Schreiner, Monika A1 - Grune, Tilman A1 - Rohn, Sascha A1 - Ott, Christiane T1 - Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages JF - Nutrients N2 - For centuries, Amaranthus sp. were used as food, ornamentals, and medication. Molecular mechanisms, explaining the health beneficial properties of amaranth, are not yet understood, but have been attributed to secondary metabolites, such as phenolic compounds. One of the most abundant phenolic compounds in amaranth leaves is 2-caffeoylisocitric acid (C-IA) and regarding food occurrence, C-IA is exclusively found in various amaranth species. In the present study, the anti-inflammatory activity of C-IA, chlorogenic acid, and caffeic acid in LPS-challenged macrophages (RAW 264.7) has been investigated and cellular contents of the caffeic acid derivatives (CADs) were quantified in the cells and media. The CADs were quantified in the cell lysates in nanomolar concentrations, indicating a cellular uptake. Treatment of LPS-challenged RAW 264.7 cells with 10 µM of CADs counteracted the LPS effects and led to significantly lower mRNA and protein levels of inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin 6, by directly decreasing the translocation of the nuclear factor κB/Rel-like containing protein 65 into the nucleus. This work provides new insights into the molecular mechanisms that attribute to amaranth’s anti-inflammatory properties and highlights C-IA’s potential as a health-beneficial compound for future research. KW - inflammation KW - caffeic acid derivatives KW - RAW 264 KW - 7 macrophages KW - NF-kappa B KW - amaranth Y1 - 2019 U6 - https://doi.org/10.3390/nu11030571 SN - 2072-6643 VL - 11 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Franken, Nadine A1 - Degeling, Maria A1 - Preisfeld, Angelika ED - Mientus, Lukas ED - Klempin, Christiane ED - Nowak, Anna T1 - Am Puls der (digitalen) Zeit? BT - E-Peer-Assessments im Praxissemester in den Fächern Biologie und Mathematik JF - Reflexion in der Lehrkräftebildung: Empirisch – Phasenübergreifend – Interdisziplinär (Potsdamer Beiträge zur Lehrerbildung und Bildungsforschung ; 4) N2 - In diesem Beitrag wird ein geplantes digitales Lehrkonzept für die universitäre Begleitung des Praxissemesters in den Fächern Biologie und Mathematik vorgestellt. Darin setzen sich Studierende im Praxissemester selbstständig fachspezifische Schwerpunkte für die Planung, Durchführung und Reflexion von Unterrichtsprojekten in der Schule. Optimalerweise ergibt sich aus den Unterrichtsprojekten auch eine fachbezogene Fragestellung, die von den Studierenden im Zuge Forschenden Lernens ergründet werden kann. Begleitet wird der gesamte Prozess durch systematisch angeleitete E-Peer-Assessments (E-PA). Dabei treten Studierende in Peers in den digitalen, schriftlichen Dialog über Unterricht und durchlaufen gemeinsam Reflexions- und Feedbackschleifen, welche durch die universitäre Seminarleitung instruiert werden. KW - E-Peer-Assessment KW - Feedback KW - Lehrkräftebildung KW - Praxissemester KW - Reflexion Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-631402 SN - 978-3-86956-566-8 SN - 2626-3556 SN - 2626-4722 IS - 4 SP - 221 EP - 231 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - CHAP A1 - Löw, Martina A1 - Sayman, Volkan A1 - Schwerer, Jona A1 - Wolf, Hannah ED - Löw, Martina ED - Sayman, Volkan ED - Schwerer, Jona ED - Wolf, Hannah T1 - Am Ende der Globalisierung BT - über die Refiguration von Räumen T2 - Am Ende der Globalisierung Y1 - 2021 SN - 978-3-8394-5402-2 SN - 978-3-8376-5402-8 U6 - https://doi.org/10.14361/9783839454022 SP - 9 EP - 22 PB - transcript CY - Bielefeld ER -