TY - JOUR A1 - Jaiser, Ralf A1 - Akperov, Mirseid A1 - Timazhev, A. A1 - Romanowsky, Erik A1 - Handorf, Dörthe A1 - Mokhov, I. I. T1 - Linkages between arctic and mid-latitude weather and climate BT - unraveling the impact of changing sea ice and sea surface temperatures during Winter JF - Meteorologische Zeitschrift N2 - The study addresses the question, if observed changes in terms of Arctic-midlatitude linkages during winter are driven by Arctic Sea ice decline alone or if the increase of global sea surface temperatures plays an additional role. We compare atmosphere-only model experiments with ECHAM6 to ERA-Interim Reanalysis data. The model sensitivity experiment is implemented as a set of four combinations of sea ice and sea surface temperature boundary conditions. Atmospheric circulation regimes are determined and evaluated in terms of their cyclone and blocking characteristics and changes in frequency during winter. As a prerequisite, ECHAM6 reproduces general features of circulation regimes very well. Tropospheric changes induced by the change of boundary conditions are revealed and further impacts on the large-scale circulation up into the stratosphere are investigated. In early winter, the observed increase of atmospheric blocking in the region between Scandinavia and the Urals are primarily related to the changes in sea surface temperatures. During late winter, we f nd a weakened polar stratospheric vortex in the reanalysis that further impacts the troposphere. In the model sensitivity study a climatologically weakened polar vortex occurs only if sea ice is reduced and sea surface temperatures are increased together. This response is delayed compared to the reanalysis. The tropospheric response during late winter is inconclusive in the model, which is potentially related to the weak and delayed response in the stratosphere. The model experiments do not reproduce the connection between early and late winter as interpreted from the reanalysis. Potentially explaining this mismatch, we identify a discrepancy of ECHAM6 to reproduce the weakening of the stratospheric polar vortex through blocking induced upward propagation of planetary waves. KW - Weather regimes KW - Blocking KW - Cyclones KW - Wave Propagation KW - Stratosphere Y1 - 2023 U6 - https://doi.org/10.1127/metz/2023/1154 SN - 0941-2948 SN - 1610-1227 VL - 32 IS - 3 SP - 173 EP - 194 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Mayer, Dennis A1 - Lever, Fabiano A1 - Picconi, David A1 - Metje, Jan A1 - Ališauskas, Skirmantas A1 - Calegari, Francesca A1 - Düsterer, Stefan A1 - Ehlert, Christopher A1 - Feifel, Raimund A1 - Niebuhr, Mario A1 - Manschwetus, Bastian A1 - Kuhlmann, Marion A1 - Mazza, Tommaso A1 - Robinson, Matthew Scott A1 - Squibb, Richard James A1 - Trabattoni, Andrea A1 - Wallner, Måns A1 - Saalfrank, Peter A1 - Wolf, Thomas J. A. A1 - Gühr, Markus T1 - Following excited-state chemical shifts in molecular ultrafast x-ray photoelectron spectroscopy JF - Nature Communications N2 - The conversion of photon energy into other energetic forms in molecules is accompanied by charge moving on ultrafast timescales. We directly observe the charge motion at a specific site in an electronically excited molecule using time-resolved x-ray photoelectron spectroscopy (TR-XPS). We extend the concept of static chemical shift from conventional XPS by the excited-state chemical shift (ESCS), which is connected to the charge in the framework of a potential model. This allows us to invert TR-XPS spectra to the dynamic charge at a specific atom. We demonstrate the power of TR-XPS by using sulphur 2p-core-electron-emission probing to study the UV-excited dynamics of 2-thiouracil. The method allows us to discover that a major part of the population relaxes to the molecular ground state within 220–250 fs. In addition, a 250-fs oscillation, visible in the kinetic energy of the TR-XPS, reveals a coherent exchange of population among electronic states. Y1 - 2022 U6 - https://doi.org/10.1038/s41467-021-27908-y SN - 2041-1723 VL - 13 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Veh, Georg A1 - Lützow, Natalie A1 - Kharlamova, Varvara A1 - Petrakov, Dmitry A1 - Hugonnet, Romain A1 - Korup, Oliver T1 - Trends, Breaks, and Biases in the Frequency of Reported Glacier Lake Outburst Floods JF - Earth's Future N2 - Thousands of glacier lakes have been forming behind natural dams in high mountains following glacier retreat since the early 20th century. Some of these lakes abruptly released pulses of water and sediment with disastrous downstream consequences. Yet it remains unclear whether the reported rise of these glacier lake outburst floods (GLOFs) has been fueled by a warming atmosphere and enhanced meltwater production, or simply a growing research effort. Here we estimate trends and biases in GLOF reporting based on the largest global catalog of 1,997 dated glacier-related floods in six major mountain ranges from 1901 to 2017. We find that the positive trend in the number of reported GLOFs has decayed distinctly after a break in the 1970s, coinciding with independently detected trend changes in annual air temperatures and in the annual number of field-based glacier surveys (a proxy of scientific reporting). We observe that GLOF reports and glacier surveys decelerated, while temperature rise accelerated in the past five decades. Enhanced warming alone can thus hardly explain the annual number of reported GLOFs, suggesting that temperature-driven glacier lake formation, growth, and failure are weakly coupled, or that outbursts have been overlooked. Indeed, our analysis emphasizes a distinct geographic and temporal bias in GLOF reporting, and we project that between two to four out of five GLOFs on average might have gone unnoticed in the early to mid-20th century. We recommend that such biases should be considered, or better corrected for, when attributing the frequency of reported GLOFs to atmospheric warming. Y1 - 2022 U6 - https://doi.org/10.1029/2021EF002426 SN - 2328-4277 VL - 10 SP - 1 EP - 14 PB - Wiley-Blackwell CY - Hoboken, New Jersey ET - 3 ER - TY - JOUR A1 - Bouamra, Marwa A1 - Zouhal, Hassane A1 - Ratel, Sébastien A1 - Makhlouf, Issam A1 - Bezrati, Ikram A1 - Chtara, Moktar A1 - Behm, David George A1 - Granacher, Urs A1 - Chaouachi, Anis T1 - Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity JF - Frontiers in Physiology N2 - The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50% resistance (RT) and 50% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 ± 0.9 years; body-mass-index (BMI): 31.2 ± 4.8 kg·m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 sets×12 runs at 80–110% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3–4 sets × 10 repetition maximum (RM) and CT (n = 13): 50% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth. KW - weight loss KW - adolescents KW - high-intensity-interval training KW - resistance training KW - DXA KW - matched time Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.869063 SN - 1664-042X VL - 13 SP - 1 EP - 16 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Heistermann, Maik A1 - Bogena, Heye A1 - Francke, Till A1 - Güntner, Andreas A1 - Jakobi, Jannis A1 - Rasche, Daniel A1 - Schrön, Martin A1 - Döpper, Veronika A1 - Fersch, Benjamin A1 - Groh, Jannis A1 - Patil, Amol A1 - Pütz, Thomas A1 - Reich, Marvin A1 - Zacharias, Steffen A1 - Zengerle, Carmen A1 - Oswald, Sascha T1 - Soil moisture observation in a forested headwater catchment: combining a dense cosmic-ray neutron sensor network with roving and hydrogravimetry at the TERENO site Wüstebach JF - Earth system science data : ESSD N2 - Cosmic-ray neutron sensing (CRNS) has become an effective method to measure soil moisture at a horizontal scale of hundreds of metres and a depth of decimetres. Recent studies proposed operating CRNS in a network with overlapping footprints in order to cover root-zone water dynamics at the small catchment scale and, at the same time, to represent spatial heterogeneity. In a joint field campaign from September to November 2020 (JFC-2020), five German research institutions deployed 15 CRNS sensors in the 0.4 km2 Wüstebach catchment (Eifel mountains, Germany). The catchment is dominantly forested (but includes a substantial fraction of open vegetation) and features a topographically distinct catchment boundary. In addition to the dense CRNS coverage, the campaign featured a unique combination of additional instruments and techniques: hydro-gravimetry (to detect water storage dynamics also below the root zone); ground-based and, for the first time, airborne CRNS roving; an extensive wireless soil sensor network, supplemented by manual measurements; and six weighable lysimeters. Together with comprehensive data from the long-term local research infrastructure, the published data set (available at https://doi.org/10.23728/b2share.756ca0485800474e9dc7f5949c63b872; Heistermann et al., 2022) will be a valuable asset in various research contexts: to advance the retrieval of landscape water storage from CRNS, wireless soil sensor networks, or hydrogravimetry; to identify scale-specific combinations of sensors and methods to represent soil moisture variability; to improve the understanding and simulation of land–atmosphere exchange as well as hydrological and hydrogeological processes at the hillslope and the catchment scale; and to support the retrieval of soil water content from airborne and spaceborne remote sensing platforms. Y1 - 2022 U6 - https://doi.org/10.5194/essd-14-2501-2022 SN - 1866-3516 SN - 1866-3508 VL - 14 IS - 5 SP - 2501 EP - 2519 PB - Copernicus CY - Katlenburg-Lindau ER - TY - JOUR A1 - Jebabli, Nidhal A1 - Zouhal, Hassane A1 - Boullosa, Daniel A1 - Govindasamy, Karuppasamy A1 - Tourny, Claire A1 - Hackney, Anthony C. A1 - Granacher, Urs A1 - Ben Abderrahman, Abderraouf T1 - The effects of preferred music and its timing on performance, pacing, and psychophysiological responses during the 6-min test JF - Journal of human kinetics N2 - The aim of this study was to investigate the effects of listening to preferred music during a warm up or exercise, on performance during a 6-min all-out exercise test (6-MT) in young adult males. Twenty-five healthy males volunteered to participate in this study. Following a within subject design, participants performed three test conditions (MDT: music during the test; MDW: music during the warm-up; WM: without music) in random order. Outcomes included mean running speed over the 6-min test (MRS6), total distance covered (TDC), heart rate responses (HRpeak, HRmean), blood lactate (3-min after the test), and the rating of perceived exertion (RPE); additionally, feeling scale scores were recorded. Listening to preferred music during running resulted in significant TDC (Delta up arrow 10%, p=0.006, ES=0.80) and MRS6 (Delta up arrow 14%, p=0.012, ES=1.02) improvement during the 6-MT, improvement was also noted for the warm-up with music condition (TDC:Delta up arrow 8%, p=0.028, ES=0.63; MRS6:Delta up arrow 8%, p=0.032, ES=0.61). A similar reverse "J-shaped" pacing profile was detected during the three conditions. Blood lactate was lower in the MDT condition by 8% (p=0.01, ES=1.10), but not the MDW condition, compared to MW. In addition, no statistically significant differences were found between the test sessions for the HR, RPE, and feeling scale scores. In conclusion, listening to music during exercise testing would be more beneficial for optimal TDC and MRS6 performances compared to MDW and WM. KW - rating of perceived exertion KW - work-rate distribution KW - blood lactate; KW - aerobic exercise Y1 - 2022 U6 - https://doi.org/10.2478/hukin-2022-0038 SN - 1640-5544 SN - 1899-7562 VL - 82 IS - 1 SP - 123 EP - 133 PB - Academy of Physical Education CY - Katowice ER - TY - GEN A1 - Reil, Daniela A1 - Rosenfeld, Ulrike A1 - Imholt, Christian A1 - Schmidt, Sabrina A1 - Ulrich, Rainer G. A1 - Eccard, Jana A1 - Jacob, Jens T1 - Puumala hantavirus infections in bank vole populations BT - host and virus dynamics in Central Europe T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010–2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 957 KW - Myodes glareolus KW - population dynamics KW - Puumala virus seroprevalence KW - space use KW - survival Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431232 SN - 1866-8372 IS - 957 ER - TY - BOOK A1 - Denz, Rebekka A1 - Stellmacher, Martha A1 - Ullrich, Rebecca A1 - Benar, Jael Andra A1 - Uličná, Lenka A1 - Martini, Annett A1 - Allgaier-Honal, Recha A1 - Abramowicz, Isidoro A1 - Ariel, Neri Y. A1 - Stürzebecher, Maria A1 - Weinhold, Beate A1 - Singer-Brehm, Elisabeth ED - Denz, Rebekka ED - Stellmacher, Martha ED - Ullrich, Rebecca T1 - Genisa-Blätter IV N2 - Auch wenn Genisot – jüdische Ablagen nicht mehr verwendeter Bücher und Kultgegenstände – in der bisherigen historischen Forschung selten beachtet werden, sind sie als Quellen aus originär jüdischer Hand von hoher Bedeutung und können unser Verständnis der Umsetzung von Ritualen im Kontext der lokalen Gemeinde vertiefen. Der Schwerpunkt der ‚Genisa-Blätter IV‘ liegt auf Fragen nach jüdisch-rituellen Praktiken und ihrer Bedeutung, ihren Objekten und Akteuren. Acht wissenschaftliche und ein essayistischer Beitrag nähern sich diesen Themen über konkrete Funde aus Genisot mitteleuropäischer jüdischer Gemeinden, von religiösen Texten wie dem Fragment einer Torarolle und einem Minhagim-Buch über Personaldokumente bis hin zu Musiknoten und Kleidungsstücken. KW - Genisa KW - Jüdische Studien KW - Ritual KW - Ländliches Judentum KW - Geniza KW - Jewish Studies KW - ritual KW - Rural Jewry Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-555356 SN - 978-3-86956-539-2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Denz, Rebekka A1 - Rudolf, Gabi A1 - Singer-Brehm, Elisabeth A1 - Sowa, Oliver A1 - Müller, Monika A1 - Schulz, Michael Karl A1 - Uličná, Lenka A1 - Ullrich, Rebecca A1 - Weinhold, Beate A1 - Fuchs, Stefanie ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Genisa-Blätter III N2 - Ursprünglich sollten die „Genisa-Blätter III“ ein europäisches Projekt werden. Veröffentlicht werden sollten Quellen aus ­Genisot, die im vormals deutschsprachigen Raum gehoben wurden. Das Vorhaben scheiterte. Nunmehr sind im Band sieben Beiträge versammelt, in denen kenntnisreich Funde aus den Ablagen in Alsenz, Altenschönbach, Memmelsdorf, Reckendorf und Veitshöchheim besprochen werden. Der achte Aufsatz knüpft am internationalen Vorhaben an: Im Mittelpunkt des Artikels stehen drei Genisafunde aus Tschechien, genauer gesagt aus den beiden ostböhmischen Ortschaften Luže und Rychnov nad Kněžnou. Alle acht Beiträge gemeinsam verdeutlichen die inhaltliche Spannbreite von Genisot, die sich die Forschung zunutze machen kann: Sie reicht von Aspekten der Wirtschaft und des Rechts, über die Religion bis hin zum alltäglichen Leben und bietet jeweils eigene Geschichten im Spannungsfeld des möglichen Scheiterns. KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Landesgeschichte KW - Franken KW - Ländliches Judentum KW - regional history KW - Franconia KW - Rural Jewry Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435289 SN - 978-3-86956-470-8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Fuchs, Stefanie ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Worum geht es hier eigentlich? BT - ein illustriertes Fragment aus der Reckendorfer Genisa JF - Genisa Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Landesgeschichte KW - Ländliches Judentum KW - Franken KW - Rural Jewry KW - regional history KW - Franconia Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470986 SN - 978-3-86956-470-8 SP - 123 EP - 138 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ullrich, Rebecca ED - Denz, Rebekka ED - Rudolf, Gabi T1 - „Sage diesen Psalm und er wird dir einen guten Anteil bringen“ BT - eine Abschrift des ‚Sefer Shimmush Tehillim‘ in der Reckendorfer Genisa JF - Genisa Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Franconia KW - Rural Jewry KW - regional history KW - Landesgeschichte KW - Ländliches Judentum Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470967 SN - 978-3-86956-470-8 SP - 81 EP - 98 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Singer-Brehm, Elisabeth ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Neues zur Historie von der Schönen Melusina JF - Genisa Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470905 SN - 978-3-86956-470-8 SP - 13 EP - 28 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schulz, Michael Karl ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Ein Empfehlungsschreiben für einen Sofer in Westfalen aus dem Jahr 1755/17561 KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470936 SN - 978-3-86956-470-8 SP - 43 EP - 57 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Uličná, Lenka ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Amulets Found in Bohemian Genizot BT - a first approach KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Franconia KW - Landesgeschichte KW - Ländliches Judentum KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470952 SN - 978-3-86956-470-8 SP - 69 EP - 80 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Sowa, Oliver ED - Denz, Rebekka ED - Rudolf, Gabi T1 - „Einhundertfün[f]zig Würtzb. maß Haber“ BT - ein jüdisch-christliches Handelsgeschäftaus dem Jahr 1709 JF - Genisa-Blätter III KW - Genisa KW - Jüdische Studien KW - Geniza KW - Jewish Studies KW - Franken KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Rural Jewry KW - regional history Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470919 SN - 978-3-86956-470-8 SP - 29 EP - 38 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR ED - Philipowski, Katharina T1 - Medieval forms of first-person narration II BT - narrativity and discoursivity (Villa Vigoni Talks II) T2 - Beiträge zur mediävistischen Erzählforschung N2 - One of the central features that medieval narratives in the first person have in common is their specific structure. Most of them are not continuously and coherently narrative, but in most cases include long discursive sections or textual elements such as letters, prayers, songs, or dialogues. The classification of these texts as narrative literature is thus anything but self-evident. The contributions to this volume examine how first-person discursivity and narrativity interact in French, German, and Italian narratives, what interrelation exists between the first-person narrative stance and discursivity, and how the literary forms of narrativity and discursivity (each of which is assigned a specific tense, namely the past tense and the present tense) relate to each other. KW - Mediävistik KW - Erzählforschung Y1 - 2022 U6 - https://doi.org/10.25619/BmE_H20225 SN - 2568-9967 VL - 14 IS - Special Issue PB - University of Oldenburg Press CY - Oldenburg ER - TY - GEN A1 - Philipowski, Katharina ED - Philipowski, Katharina T1 - Einführende Bemerkungen zu Diskursivität und Narrativität T2 - Medieval Forms of First-Person Narration: Narrativity and Discoursivity (Villa Vigoni Talks II) T2 - Beiträge zur mediävistischen Erzählforschung KW - Mediävistik KW - Erzählforschung Y1 - 2022 U6 - https://doi.org/10.25619/BmE20225222 SN - 2568-9967 VL - 14 IS - Special Issue SP - 1 EP - 12 PB - University of Oldenburg Press CY - Oldenburg ER - TY - JOUR A1 - Ilicic, Doris A1 - Woodhouse, Jason Nicholas A1 - Karsten, Ulf A1 - Zimmermann, Jonas A1 - Wichard, Thomas A1 - Quartino, Maria Liliana A1 - Campana, Gabriela Laura A1 - Livenets, Alexandra A1 - Van den Wyngaert, Silke A1 - Grossart, Hans-Peter T1 - Antarctic Glacial Meltwater Impacts the Diversity of Fungal Parasites Associated With Benthic Diatoms in Shallow Coastal Zones JF - Frontiers in microbiology N2 - Aquatic ecosystems are frequently overlooked as fungal habitats, although there is increasing evidence that their diversity and ecological importance are greater than previously considered. Aquatic fungi are critical and abundant components of nutrient cycling and food web dynamics, e.g., exerting top-down control on phytoplankton communities and forming symbioses with many marine microorganisms. However, their relevance for microphytobenthic communities is almost unexplored. In the light of global warming, polar regions face extreme changes in abiotic factors with a severe impact on biodiversity and ecosystem functioning. Therefore, this study aimed to describe, for the first time, fungal diversity in Antarctic benthic habitats along the salinity gradient and to determine the co-occurrence of fungal parasites with their algal hosts, which were dominated by benthic diatoms. Our results reveal that Ascomycota and Chytridiomycota are the most abundant fungal taxa in these habitats. We show that also in Antarctic waters, salinity has a major impact on shaping not just fungal but rather the whole eukaryotic community composition, with a diversity of aquatic fungi increasing as salinity decreases. Moreover, we determined correlations between putative fungal parasites and potential benthic diatom hosts, highlighting the need for further systematic analysis of fungal diversity along with studies on taxonomy and ecological roles of Chytridiomycota. KW - Antarctica KW - aquatic fungi KW - Chytridiomycota KW - phytoplankton host KW - salinity gradient KW - Illumina amplicon sequencing KW - Carlini Station Y1 - 2022 U6 - https://doi.org/10.3389/fmicb.2022.805694 SN - 1664-302X IS - 13 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Garcia, Sarahi L. A1 - Buck, Moritz A1 - Hamilton, Joshua J. A1 - Wurzbacher, Christian A1 - Grossart, Hans-Peter A1 - McMahon, Katherine D. A1 - Eiler, Alexander T1 - Model communities hint at promiscuous metabolic linkages between ubiquitous free-living freshwater bacteria JF - mSphere N2 - Genome streamlining is frequently observed in free-living aquatic microorganisms and results in physiological dependencies between microorganisms. However, we know little about the specificity of these microbial associations. In order to examine the specificity and extent of these associations, we established mixed cultures from three different freshwater environments and analyzed the cooccurrence of organisms using a metagenomic time series. Free-living microorganisms with streamlined genomes lacking multiple biosynthetic pathways showed no clear recurring pattern in their interaction partners. Free-living freshwater bacteria form promiscuous cooperative associations. This notion contrasts with the well-documented high specificities of interaction partners in host-associated bacteria. Considering all data together, we suggest that highly abundant free-living bacterial lineages are functionally versatile in their interactions despite their distinct streamlining tendencies at the single-cell level. This metabolic versatility facilitates interactions with a variable set of community members. KW - community KW - interactions KW - metagenomics KW - microbial ecology KW - mixed cultures KW - promiscuous Y1 - 2018 U6 - https://doi.org/10.1128/mSphere.00202-18 SN - 2379-5042 VL - 3 IS - 3 PB - American Society for Microbiology CY - Washington ER - TY - JOUR A1 - Günthel, Marco A1 - Donis, Daphne A1 - Kirillin, Georgiy A1 - Ionescu, Danny A1 - Bizic, Mina A1 - McGinnis, Daniel F. A1 - Grossart, Hans-Peter A1 - Tang, Kam W. T1 - Contribution of oxic methane production to surface methane emission in lakes and its global importance JF - Nature Communications N2 - Recent discovery of oxic methane production in sea and lake waters, as well as wetlands, demands re-thinking of the global methane cycle and re-assessment of the contribution of oxic waters to atmospheric methane emission. Here we analysed system-wide sources and sinks of surface-water methane in a temperate lake. Using a mass balance analysis, we show that internal methane production in well-oxygenated surface water is an important source for surface-water methane during the stratified period. Combining our results and literature reports, oxic methane contribution to emission follows a predictive function of littoral sediment area and surface mixed layer volume. The contribution of oxic methane source(s) is predicted to increase with lake size, accounting for the majority (>50%) of surface methane emission for lakes with surface areas >1 km(2). Y1 - 2019 U6 - https://doi.org/10.1038/s41467-019-13320-0 SN - 2041-1723 VL - 10 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Srivastava, Abhishek A1 - Murugaiyan, Jayaseelan A1 - Garcia, Juan A. L. A1 - De Corte, Daniele A1 - Hoetzinger, Matthias A1 - Eravci, Murat A1 - Weise, Christoph A1 - Kumar, Yadhu A1 - Roesler, Uwe A1 - Hahn, Martin W. A1 - Grossart, Hans-Peter T1 - Combined Methylome, Transcriptome and Proteome Analyses Document Rapid Acclimatization of a Bacterium to Environmental Changes JF - Frontiers in Microbiology N2 - Polynucleobacter asymbioticus strain QLW-P1DMWA-1T represents a group of highly successful heterotrophic ultramicrobacteria that is frequently very abundant (up to 70% of total bacterioplankton) in freshwater habitats across all seven continents. This strain was originally isolated from a shallow Alpine pond characterized by rapid changes in water temperature and elevated UV radiation due to its location at an altitude of 1300 m. To elucidate the strain’s adjustment to fluctuating environmental conditions, we recorded changes occurring in its transcriptomic and proteomic profiles under contrasting experimental conditions by simulating thermal conditions in winter and summer as well as high UV irradiation. To analyze the potential connection between gene expression and regulation via methyl group modification of the genome, we also analyzed its methylome. The methylation pattern differed between the three treatments, pointing to its potential role in differential gene expression. An adaptive process due to evolutionary pressure in the genus was deduced by calculating the ratios of non-synonymous to synonymous substitution rates for 20 Polynucleobacter spp. genomes obtained from geographically diverse isolates. The results indicate purifying selection. KW - DNA modification KW - gene expression KW - freshwater heterotrophic bacteria KW - UV radiation KW - purifying selection Y1 - 2020 U6 - https://doi.org/10.3389/fmicb.2020.544785 SN - 1664-302X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Gubelit, Yulia I. A1 - Grossart, Hans-Peter T1 - New Methods, New Concepts BT - What Can Be Applied to Freshwater Periphyton? JF - Frontiers in Microbiology N2 - Microbial interactions play an essential role in aquatic ecosystems and are of the great interest for both marine and freshwater ecologists. Recent development of new technologies and methods allowed to reveal many functional mechanisms and create new concepts. Yet, many fundamental aspects of microbial interactions have been almost exclusively studied for marine pelagic and benthic ecosystems. These studies resulted in a formulation of the Black Queen Hypothesis, a development of the phycosphere concept for pelagic communities, and a realization of microbial communication as a key mechanism for microbial interactions. In freshwater ecosystems, especially for periphyton communities, studies focus mainly on physiology, biodiversity, biological indication, and assessment, but the many aspects of microbial interactions are neglected to a large extent. Since periphyton plays a great role for aquatic nutrient cycling, provides the basis for water purification, and can be regarded as a hotspot of microbial biodiversity, we highlight that more in-depth studies on microbial interactions in periphyton are needed to improve our understanding on functioning of freshwater ecosystems. In this paper we first present an overview on recent concepts (e.g., the “Black Queen Hypothesis”) derived from state-of-the-art OMICS methods including metagenomics, metatranscriptomics, and metabolomics. We then point to the avenues how these methods can be applied for future studies on biodiversity and the ecological role of freshwater periphyton, a yet largely neglected component of many freshwater ecosystems. KW - freshwater KW - lake periphyton KW - microbial interactions KW - Black Queen Hypothesis KW - OMICs tools Y1 - 2020 U6 - https://doi.org/10.3389/fmicb.2020.01275 SN - 1664-302X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Klaus, Benita A1 - Müller, Patrick A1 - van Wickeren, Nora A1 - Dordevic, Milos A1 - Schmicker, Marlen A1 - Zdunczyk, Yael A1 - Brigadski, Tanja A1 - Lessmann, Volkmar A1 - Vielhaber, Stefan A1 - Schreiber, Stefanie A1 - Müller, Notger Germar T1 - Structural and functional brain alterations in patients with myasthenia gravis JF - Brain communications N2 - Myasthenia gravis is an autoimmune disease affecting neuromuscular transmission and causing skeletal muscle weakness. Additionally, systemic inflammation, cognitive deficits and autonomic dysfunction have been described. However, little is known about myasthenia gravis-related reorganization of the brain. In this study, we thus investigated the structural and functional brain changes in myasthenia gravis patients. Eleven myasthenia gravis patients (age: 70.64 +/- 9.27; 11 males) were compared to age-, sex- and education-matched healthy controls (age: 70.18 +/- 8.98; 11 males). Most of the patients (n = 10, 0.91%) received cholinesterase inhibitors. Structural brain changes were determined by applying voxel-based morphometry using high-resolution T-1-weighted sequences. Functional brain changes were assessed with a neuropsychological test battery (including attention, memory and executive functions), a spatial orientation task and brain-derived neurotrophic factor blood levels. Myasthenia gravis patients showed significant grey matter volume reductions in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. Furthermore, myasthenia gravis patients showed significantly lower performance in executive functions, working memory (Spatial Span, P = 0.034, d = 1.466), verbal episodic memory (P = 0.003, d = 1.468) and somatosensory-related spatial orientation (Triangle Completion Test, P = 0.003, d = 1.200). Additionally, serum brain-derived neurotrophic factor levels were significantly higher in myasthenia gravis patients (P = 0.001, d = 2.040). Our results indicate that myasthenia gravis is associated with structural and functional brain alterations. Especially the grey matter volume changes in the cingulate gyrus and the inferior parietal lobe could be associated with cognitive deficits in memory and executive functions. Furthermore, deficits in somatosensory-related spatial orientation could be associated with the lower volumes in the inferior parietal lobe. Future research is needed to replicate these findings independently in a larger sample and to investigate the underlying mechanisms in more detail. Klaus et al. compared myasthenia gravis patients to matched healthy control subjects and identified functional alterations in memory functions as well as structural alterations in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. KW - myasthenia gravis KW - neuroplasticity KW - VBM KW - neuropsychological testing KW - BDNF Y1 - 2022 U6 - https://doi.org/10.1093/braincomms/fcac018 SN - 2632-1297 VL - 4 IS - 1 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Zhang, Zhihao A1 - Wang, Ting A1 - Kuang, Jin A1 - Herold, Fabian A1 - Ludyga, Sebastian A1 - Li, Jingming A1 - Hall, Daniel L. A1 - Taylor, Alyx A1 - Healy, Sean A1 - Yeung, Albert S. A1 - Kramer, Arthur F. A1 - Zou, Liye T1 - The roles of exercise tolerance and resilience in the effect of physical activity on emotional states among college students JF - International Journal of Clinical and Health Psychology N2 - Background/objective: Negative emotional states, such as depression, anxiety, and stress challenge health care due to their long-term consequences for mental disorders. Accumulating evidence indicates that regular physical activity (PA) can positively influence negative emotional states. Among possible candidates, resilience and exercise tolerance in particular have the potential to partly explain the positive effects of PA on negative emotional states. Thus, the aim of this study was to investigate the association between PA and negative emotional states, and further determine the mediating effects of exercise tolerance and resilience in such a relationship. Method: In total, 1117 Chinese college students (50.4% female, Mage=18.90, SD=1.25) completed a psychosocial battery, including the 21-item Depression Anxiety Stress Scale (DASS-21), the Connor-Davidson Resilience Scale (CD-RISC), the Preference for and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q), and the International Physical Activity Questionnaire short form (IPAQ-SF). Regression analysis was used to identify the serial multiple mediation, controlling for gender, age and BMI. Results: PA, exercise intensity-tolerance, and resilience were significantly negatively correlated with negative emotional states (Ps<.05). Further, exercise tolerance and resilience partially mediated the relationship between PA and negative emotional states. Conclusions: Resilience and exercise intensity-tolerance can be achieved through regularly engaging in PA, and these newly observed variables play critical roles in prevention of mental illnesses, especially college students who face various challenges. Recommended amount of PA should be incorporated into curriculum or sport clubs within a campus environment. KW - Exercise tolerance KW - Resilience KW - Physical activity KW - Emotion KW - Depression Y1 - 2022 U6 - https://doi.org/10.1016/j.ijchp.2022.100312 SN - 1697-2600 SN - 1576-7329 VL - 22 IS - 3 PB - Elsevier CY - New York ER - TY - JOUR A1 - Herold, Fabian A1 - Behrendt, Tom A1 - Meißner, Caroline A1 - Müller, Notger Germar A1 - Schega, Lutz T1 - The Influence of acute sprint interval training on cognitive performance of healthy younger adults JF - International journal of environmental research and public health : IJERPH / Molecular Diversity Preservation International N2 - There is considerable evidence showing that an acute bout of physical exercises can improve cognitive performance, but the optimal exercise characteristics (e.g., exercise type and exercise intensity) remain elusive. In this regard, there is a gap in the literature to which extent sprint interval training (SIT) can enhance cognitive performance. Thus, this study aimed to investigate the effect of a time-efficient SIT, termed as "shortened-sprint reduced-exertion high-intensity interval training" (SSREHIT), on cognitive performance. Nineteen healthy adults aged 20-28 years were enrolled and assessed for attentional performance (via the d2 test), working memory performance (via Digit Span Forward/Backward), and peripheral blood lactate concentration immediately before and 10 min after an SSREHIT and a cognitive engagement control condition (i.e., reading). We observed that SSREHIT can enhance specific aspects of attentional performance, as it improved the percent error rate (F%) in the d-2 test (t (18) = -2.249, p = 0.037, d = -0.516), which constitutes a qualitative measure of precision and thoroughness. However, SSREHIT did not change other measures of attentional or working memory performance. In addition, we observed that the exercise-induced increase in the peripheral blood lactate levels correlated with changes in attentional performance, i.e., the total number of responses (GZ) (r(m) = 0.70, p < 0.001), objective measures of concentration (SKL) (r(m) = 0.73, p < 0.001), and F% (r(m) = -0.54, p = 0.015). The present study provides initial evidence that a single bout of SSREHIT can improve specific aspects of attentional performance and conforming evidence for a positive link between cognitive improvements and changes in peripheral blood lactate levels. KW - sprint interval training KW - acute exercise KW - cognition KW - lactate KW - exercise-cognition Y1 - 2022 U6 - https://doi.org/10.3390/ijerph19010613 SN - 1660-4601 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Tjaden, Jasper A1 - Seuthe, Miriam A1 - Weinert, Sebastian T1 - Recruiting refugees to reduce labour shortages in health care professions BT - experimental evidence on the potential of foreign-language outreach on social media JF - Human resources for health N2 - Background Many high-income countries are grappling with severe labour shortages in the healthcare sector. Refugees and recent migrants present a potential pool for staff recruitment due to their higher unemployment rates, younger age, and lower average educational attainment compared to the host society's labour force. Despite this, refugees and recent migrants, often possessing limited language skills in the destination country, are frequently excluded from traditional recruitment campaigns conducted solely in the host country’s language. Even those with intermediate language skills may feel excluded, as destination-country language advertisements are perceived as targeting only native speakers. This study experimentally assesses the effectiveness of a recruitment campaign for nursing positions in a German care facility, specifically targeting Arabic and Ukrainian speakers through Facebook advertisements. Methods We employ an experimental design (AB test) approximating a randomized controlled trial, utilizing Facebook as the delivery platform. We compare job advertisements for nursing positions in the native languages of Arabic and Ukrainian speakers (treatment) with the same advertisements displayed in German (control) for the same target group in the context of a real recruitment campaign for nursing jobs in Berlin, Germany. Our evaluation includes comparing link click rates, visits to the recruitment website, initiated applications, and completed applications, along with the unit cost of these indicators. We assess statistical significance in group differences using the Chi-squared test. Results We find that recruitment efforts in the origin language were 5.6 times (Arabic speakers) and 1.9 times (Ukrainian speakers) more effective in initiating nursing job applications compared to the standard model of German-only advertisements among recent migrants and refugees. Overall, targeting refugees and recent migrants was 2.4 (Ukrainians) and 10.8 (Arabic) times cheaper than targeting the reference group of German speakers indicating higher interest among these groups. Conclusions The results underscore the substantial benefits for employers in utilizing targeted recruitment via social media aimed at foreign-language communities within the country. This strategy, which is low-cost and low effort compared to recruiting abroad or investing in digitalization, has the potential for broad applicability in numerous high-income countries with sizable migrant communities. Increased employment rates among underemployed refugee and migrant communities, in turn, contribute to reducing poverty, social exclusion, public expenditure, and foster greater acceptance of newcomers within the receiving society. KW - social media KW - Facebook KW - nursing KW - refugee KW - migrant KW - recruitment Y1 - 2024 U6 - https://doi.org/10.1186/s12960-024-00933-w SN - 1478-4491 VL - 22 SP - 1 EP - 9 PB - Biomed Central CY - London ER - TY - JOUR A1 - Tjaden, Jasper A1 - Haarmann, Esther A1 - Savaskan, Nicolai T1 - Experimental evidence on improving COVID-19 vaccine outreach among migrant communities on social media JF - Scientific reports N2 - Studies from several countries suggest that COVID-19 vaccination rates are lower among migrants compared to the general population. Urgent calls have been made to improve vaccine outreach to migrants, however, there is limited evidence on effective approaches, especially using social media. We assessed a targeted, low-cost, Facebook campaign disseminating COVID-19 vaccine information among Arabic, Turkish and Russian speakers in Germany (N = 888,994). As part of the campaign, we conducted two randomized, online experiments to assess the impact of the advertisement (1) language and (2) depicted messenger (government authority, religious leader, doctor or family). Key outcomes included reach, click-through rates, conversion rates and cost-effectiveness. Within 29 days, the campaign reached 890 thousand Facebook users. On average, 2.3 individuals accessed the advertised COVID-19 vaccination appointment tool for every euro spent on the campaign. Migrants were 2.4 (Arabic), 1.8 (Russian) and 1.2 (Turkish) times more likely to click on advertisements translated to their native language compared to German-language advertisements. Furthermore, findings showed that government representatives can be more successful in engaging migrants online compared to other messengers, despite common claims of lower trust in government institutions among migrants. This study highlights the potential of tailored, and translated, vaccination campaigns on social media for reaching migrants who may be left out by traditional media campaigns. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-20340-2 SN - 2045-2322 VL - 12 PB - Springer Nature CY - London ER - TY - JOUR A1 - Fischer, Martin H. A1 - Winter, Bodo A1 - Felisatti, Arianna A1 - Myachykov, Andriy A1 - Jeglinski-Mende, Melinda A. A1 - Shaki, Samuel T1 - More instructions make fewer subtractions JF - Frontiers in psychology / Frontiers Research Foundation N2 - Research on problem solving offers insights into how humans process task-related information and which strategies they use (Newell and Simon, 1972; Öllinger et al., 2014). Problem solving can be defined as the search for possible changes in one's mind (Kahneman, 2003). In a recent study, Adams et al. (2021) assessed whether the predominant problem solving strategy when making changes involves adding or subtracting elements. In order to do this, they used several examples of simple problems, such as editing text or making visual patterns symmetrical, either in naturalistic settings or on-line. The essence of the authors' findings is a strong preference to add rather than subtract elements across a diverse range of problems, including the stabilizing of artifacts, creating symmetrical patterns, or editing texts. More specifically, they succeeded in demonstrating that “participants were less likely to identify advantageous subtractive changes when the task did not (vs. did) cue them to consider subtraction, when they had only one opportunity (vs. several) to recognize the shortcomings of an additive search strategy or when they were under a higher (vs. lower) cognitive load” (Adams et al., 2021, p. 258). Addition and subtraction are generally defined as de-contextualized mathematical operations using abstract symbols (Russell, 1903/1938). Nevertheless, understanding of both symbols and operations is informed by everyday activities, such as making or breaking objects (Lakoff and Núñez, 2000; Fischer and Shaki, 2018). The universal attribution of “addition bias” or “subtraction neglect” to problem solving activities is perhaps a convenient shorthand but it overlooks influential framing effects beyond those already acknowledged in the report and the accompanying commentary (Meyvis and Yoon, 2021). Most importantly, while Adams et al.'s study addresses an important issue, their very method of verbally instructing participants, together with lack of control over several known biases, might render their findings less than conclusive. Below, we discuss our concerns that emerged from the identified biases, namely those regarding the instructions and the experimental materials. Moreover, we refer to research from mathematical cognition that provides new insights into Adams et al.'s findings. KW - problem solving KW - addition KW - subtraction KW - cognitive bias KW - SNARC Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.720616 SN - 1664-1078 VL - 12 SP - 1 EP - 3 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Zurell, Damaris A1 - König, Christian A1 - Malchow, Anne-Kathleen A1 - Kapitza, Simon A1 - Bocedi, Greta A1 - Travis, Justin M. J. A1 - Fandos, Guillermo T1 - Spatially explicit models for decision-making in animal conservation and restoration JF - Ecography : pattern and diversity in ecology / Nordic Ecologic Society Oikos N2 - Models are useful tools for understanding and predicting ecological patterns and processes. Under ongoing climate and biodiversity change, they can greatly facilitate decision-making in conservation and restoration and help designing adequate management strategies for an uncertain future. Here, we review the use of spatially explicit models for decision support and to identify key gaps in current modelling in conservation and restoration. Of 650 reviewed publications, 217 publications had a clear management application and were included in our quantitative analyses. Overall, modelling studies were biased towards static models (79%), towards the species and population level (80%) and towards conservation (rather than restoration) applications (71%). Correlative niche models were the most widely used model type. Dynamic models as well as the gene-to-individual level and the community-to-ecosystem level were underrepresented, and explicit cost optimisation approaches were only used in 10% of the studies. We present a new model typology for selecting models for animal conservation and restoration, characterising model types according to organisational levels, biological processes of interest and desired management applications. This typology will help to more closely link models to management goals. Additionally, future efforts need to overcome important challenges related to data integration, model integration and decision-making. We conclude with five key recommendations, suggesting that wider usage of spatially explicit models for decision support can be achieved by 1) developing a toolbox with multiple, easier-to-use methods, 2) improving calibration and validation of dynamic modelling approaches and 3) developing best-practise guidelines for applying these models. Further, more robust decision-making can be achieved by 4) combining multiple modelling approaches to assess uncertainty, and 5) placing models at the core of adaptive management. These efforts must be accompanied by long-term funding for modelling and monitoring, and improved communication between research and practise to ensure optimal conservation and restoration outcomes. KW - adaptive management KW - biodiversity conservation KW - cost optimisation KW - ecosystem restoration KW - global change KW - predictive models Y1 - 2021 U6 - https://doi.org/10.1111/ecog.05787 SN - 1600-0587 IS - 4 SP - 1 EP - 16 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - König, Christian A1 - Weigelt, Patrick A1 - Taylor, Amanda A1 - Stein, Anke A1 - Dawson, Wayne A1 - Essl, Franz A1 - Pergl, Jan A1 - Pyšek, Petr A1 - Kleunen, Mark van A1 - Winter, Marten A1 - Chatelain, Cyrille A1 - Wieringa, Jan J. A1 - Krestov, Pavel A1 - Kreft, Holger T1 - Source pools and disharmony of the world’s island floras JF - Ecography N2 - Island disharmony refers to the biased representation of higher taxa on islands compared to their mainland source regions and represents a central concept in island biology. Here, we develop a generalizable framework for approximating these source regions and conduct the first global assessment of island disharmony and its underlying drivers. We compiled vascular plant species lists for 178 oceanic islands and 735 mainland regions. Using mainland data only, we modelled species turnover as a function of environmental and geographic distance and predicted the proportion of shared species between each island and mainland region. We then quantified the over- or under-representation of families on individual islands (representational disharmony) by contrasting the observed number of species against a null model of random colonization from the mainland source pool, and analysed the effects of six family-level functional traits on the resulting measure. Furthermore, we aggregated the values of representational disharmony per island to characterize overall taxonomic bias of a given flora (compositional disharmony), and analysed this second measure as a function of four island biogeographical variables. Our results indicate considerable variation in representational disharmony both within and among plant families. Examples of generally over-represented families include Urticaceae, Convolvulaceae and almost all pteridophyte families. Other families such as Asteraceae and Orchidaceae were generally under-represented, with local peaks of over-representation in known radiation hotspots. Abiotic pollination and a lack of dispersal specialization were most strongly associated with an insular over-representation of families, whereas other family-level traits showed minor effects. With respect to compositional disharmony, large, high-elevation islands tended to have the most disharmonic floras. Our results provide important insights into the taxon- and island-specific drivers of disharmony. The proposed framework allows overcoming the limitations of previous approaches and provides a quantitative basis for incorporating functional and phylogenetic approaches into future studies of island disharmony. KW - assembly processes KW - biotic filtering KW - dispersal filtering KW - environmental filtering KW - generalized dissimilarity modelling KW - island disharmony KW - island syndromes KW - source regions KW - vascular plants Y1 - 2020 VL - 44 IS - 1 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Müller, Marik A1 - Nedielkov, Ruslan A1 - Arndt, Katja M. T1 - Strategies for Enzymatic Inactivation of the Veterinary Antibiotic Florfenicol JF - Antibiotics N2 - Large quantities of the antibiotic florfenicol are used in animal farming and aquaculture, contaminating the ecosystem with antibiotic residues and promoting antimicrobial resistance, ultimately leading to untreatable multidrug-resistant pathogens. Florfenicol-resistant bacteria often activate export mechanisms that result in resistance to various structurally unrelated antibiotics. We devised novel strategies for the enzymatic inactivation of florfenicol in different media, such as saltwater or milk. Using a combinatorial approach and selection, we optimized a hydrolase (EstDL136) for florfenicol cleavage. Reaction kinetics were followed by time-resolved NMR spectroscopy. Importantly, the hydrolase remained active in different media, such as saltwater or cow milk. Various environmentally-friendly application strategies for florfenicol inactivation were developed using the optimized hydrolase. As a potential filter device for cost-effective treatment of waste milk or aquacultural wastewater, the hydrolase was immobilized on Ni-NTA agarose or silica as carrier materials. In two further application examples, the hydrolase was used as cell extract or encapsulated with a semi-permeable membrane. This facilitated, for example, florfenicol inactivation in whole milk, which can help to treat waste milk from medicated cows, to be fed to calves without the risk of inducing antibiotic resistance. Enzymatic inactivation of antibiotics, in general, enables therapeutic intervention without promoting antibiotic resistance. KW - aquaculture KW - antibiotic inactivation KW - enzyme optimization KW - enzymatic inactivation KW - florfenicol KW - immobilization KW - industrial farming Y1 - 2022 U6 - https://doi.org/10.3390/antibiotics11040443 SN - 2079-6382 VL - 11 IS - 4 SP - 1 EP - 18 PB - MDPI CY - Basel, Schweiz ER - TY - JOUR A1 - Taleb, Aiham A1 - Rohrer, Csaba A1 - Bergner, Benjamin A1 - De Leon, Guilherme A1 - Rodrigues, Jonas Almeida A1 - Schwendicke, Falk A1 - Lippert, Christoph A1 - Krois, Joachim T1 - Self-supervised learning methods for label-efficient dental caries classification JF - Diagnostics : open access journal N2 - High annotation costs are a substantial bottleneck in applying deep learning architectures to clinically relevant use cases, substantiating the need for algorithms to learn from unlabeled data. In this work, we propose employing self-supervised methods. To that end, we trained with three self-supervised algorithms on a large corpus of unlabeled dental images, which contained 38K bitewing radiographs (BWRs). We then applied the learned neural network representations on tooth-level dental caries classification, for which we utilized labels extracted from electronic health records (EHRs). Finally, a holdout test-set was established, which consisted of 343 BWRs and was annotated by three dental professionals and approved by a senior dentist. This test-set was used to evaluate the fine-tuned caries classification models. Our experimental results demonstrate the obtained gains by pretraining models using self-supervised algorithms. These include improved caries classification performance (6 p.p. increase in sensitivity) and, most importantly, improved label-efficiency. In other words, the resulting models can be fine-tuned using few labels (annotations). Our results show that using as few as 18 annotations can produce >= 45% sensitivity, which is comparable to human-level diagnostic performance. This study shows that self-supervision can provide gains in medical image analysis, particularly when obtaining labels is costly and expensive. KW - unsupervised methods KW - self-supervised learning KW - representation learning KW - dental caries classification KW - data driven approaches KW - annotation KW - efficient deep learning Y1 - 2022 U6 - https://doi.org/10.3390/diagnostics12051237 SN - 2075-4418 VL - 12 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kindermann, Liana A1 - Dobler, Magnus A1 - Niedeggen, Daniela A1 - Chimbioputo Fabiano, Ezequiel A1 - Linstädter, Anja T1 - Dataset on woody aboveground biomass, disturbance losses, and wood density from an African savanna ecosystem JF - Data in Brief N2 - This dataset comprises tree inventories and damage assessments performed in Namibia's semi-arid Zambezi Region. Data were sampled in savannas and savanna woodlands along steep gradients of elephant population densities to capture the effects of those (and other) disturbances on individual-level and stand-level aboveground woody biomass (AGB). The dataset contains raw data on dendrometric measures and processed data on specific wood density (SWD), woody aboveground biomass, and biomass losses through disturbance impacts. Allometric proxies (height, canopy diameters, and in adult trees also stem circumferences) were recorded for n = 6,179 tree and shrub individuals. Wood samples were taken for each encountered species to measure specific wood density. These measurements have been used to estimate woody aboveground biomass via established allometric models, advanced through our improved methodologies and workflows that accounted for tree and shrub architecture shaped by disturbance impacts. To this end, we performed a detailed damage assessment on each woody individual in the field. In addition to estimations of standing biomass, our new method also delivered data on biomass losses to different disturbance agents (elephants, fire, and others) on the level of plant individuals and stands. The data presented here have been used within a study published with Ecological Indicators (Kindermann et al., 2022) to evaluate the benefits of our improved methodology in comparison to a standard reference method of aboveground biomass estimations. Additionally, it has been employed in a study on carbon storage and sequestration in vegetation and soils (Sandhage-Hofmann et al., 2021). The raw data of dendrometric measurements can be subjected to other available allometric models for biomass estimation. The processed data can be used to analyze disturbance impacts on woody aboveground biomass, or for regional carbon storage estimates. The data on species-specific wood density can be used for application to other dendrometric datasets to (re-) estimate biomass through allometric models requiring wood density. It can further be used for plant functional trait analyses. KW - Damage assessment KW - Disturbance impacts KW - Disturbance indicator KW - Elephant disturbance KW - Tree allometry KW - Specific wood density KW - Woody aboveground biomass KW - Wood specific gravity Y1 - 2022 U6 - https://doi.org/10.1016/j.dib.2022.108155 SN - 2352-3409 VL - 42 SP - 1 EP - 16 PB - Elsevier CY - Amsterdam, Niederlande ER - TY - JOUR A1 - Ruszkiewicz, Joanna A1 - Endig, Lisa A1 - Güver, Ebru A1 - Bürkle, Alexander A1 - Mangerich, Aswin T1 - Life-cycle-dependent toxicities of mono- and bifunctional alkylating agents in the 3R-compliant model organism C. elegans JF - Cells : open access journal N2 - Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C. elegans to examine the toxicities of alkylating sulphur mustard analogues, specifically the monofunctional agent 2-chloroethyl-ethyl sulphide (CEES) and the bifunctional, crosslinking agent mechlorethamine (HN2). We exposed wild-type worms at different life cycle stages (from larvae L1 to adulthood day 10) to CEES or HN2 and scored their viability 24 h later. The susceptibility of C. elegans to CEES and HN2 paralleled that of human cells, with HN2 exhibiting higher toxicity than CEES, reflected in LC50 values in the high µM to low mM range. Importantly, the effects were dependent on the worms’ developmental stage as well as organismic age: the highest susceptibility was observed in L1, whereas the lowest was observed in L4 worms. In adult worms, susceptibility to alkylating agents increased with advanced age, especially to HN2. To examine reproductive effects, L4 worms were exposed to CEES and HN2, and both the offspring and the percentage of unhatched eggs were assessed. Moreover, germline apoptosis was assessed by using ced-1p::GFP (MD701) worms. In contrast to concentrations that elicited low toxicities to L4 worms, CEES and HN2 were highly toxic to germline cells, manifesting as increased germline apoptosis as well as reduced offspring number and percentage of eggs hatched. Again, HN2 exhibited stronger effects than CEES. Compound specificity was also evident in toxicities to dopaminergic neurons–HN2 exposure affected expression of dopamine transporter DAT-1 (strain BY200) at lower concentrations than CEES, suggesting a higher neurotoxic effect. Mechanistically, nicotinamide adenine dinucleotide (NAD+) has been linked to mustard agent toxicities. Therefore, the NAD+-dependent system was investigated in the response to CEES and HN2 treatment. Overall NAD+ levels in worm extracts were revealed to be largely resistant to mustard exposure except for high concentrations, which lowered the NAD+ levels in L4 worms 24 h post-treatment. Interestingly, however, mutant worms lacking components of NAD+-dependent pathways involved in genome maintenance, namely pme-2, parg-2, and sirt-2.1 showed a higher and compound-specific susceptibility, indicating an active role of NAD+ in genotoxic stress response. In conclusion, the present results demonstrate that C. elegans represents an attractive model to study the toxicology of alkylating agents, which supports its use in mechanistic as well as intervention studies with major strength in the possibility to analyze toxicities at different life cycle stages. KW - C. elegans KW - alkylating agents KW - mustards KW - life cycle toxicities KW - neurotoxicity KW - NAD+ Y1 - 2023 U6 - https://doi.org/10.3390/cells12232728 SN - 2073-4409 VL - 12 IS - 23 PB - MDPI CY - Basel ER - TY - JOUR A1 - Langary, Damoun A1 - Küken, Anika A1 - Nikoloski, Zoran T1 - The effective deficiency of biochemical networks JF - Scientific reports N2 - The deficiency of a (bio)chemical reaction network can be conceptually interpreted as a measure of its ability to support exotic dynamical behavior and/or multistationarity. The classical definition of deficiency relates to the capacity of a network to permit variations of the complex formation rate vector at steady state, irrespective of the network kinetics. However, the deficiency is by definition completely insensitive to the fine details of the directionality of reactions as well as bounds on reaction fluxes. While the classical definition of deficiency can be readily applied in the analysis of unconstrained, weakly reversible networks, it only provides an upper bound in the cases where relevant constraints on reaction fluxes are imposed. Here we propose the concept of effective deficiency, which provides a more accurate assessment of the network’s capacity to permit steady state variations at the complex level for constrained networks of any reversibility patterns. The effective deficiency relies on the concept of nonstoichiometric balanced complexes, which we have already shown to be present in real-world biochemical networks operating under flux constraints. Our results demonstrate that the effective deficiency of real-world biochemical networks is smaller than the classical deficiency, indicating the effects of reaction directionality and flux bounds on the variation of the complex formation rate vector at steady state. Y1 - 2023 U6 - https://doi.org/10.1038/s41598-023-41767-1 SN - 2045-2322 VL - 13 PB - Springer Nature CY - London ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Kühne, Franziska T1 - Assessing Patient Preferences BT - Examination of the German Cooper-Norcross Inventory of Preferences JF - Frontiers in Psychology N2 - Despite the positive effects of including patients’ preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. KW - psychotherapy KW - preference KW - activity preference KW - preference assessment KW - validation study Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.795776 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Konak, Orhan A1 - van de Water, Robin A1 - Döring, Valentin A1 - Fiedler, Tobias A1 - Liebe, Lucas A1 - Masopust, Leander A1 - Postnov, Kirill A1 - Sauerwald, Franz A1 - Treykorn, Felix A1 - Wischmann, Alexander A1 - Gjoreski, Hristijan A1 - Luštrek, Mitja A1 - Arnrich, Bert T1 - HARE BT - unifying the human activity recognition engineering workflow JF - Sensors N2 - Sensor-based human activity recognition is becoming ever more prevalent. The increasing importance of distinguishing human movements, particularly in healthcare, coincides with the advent of increasingly compact sensors. A complex sequence of individual steps currently characterizes the activity recognition pipeline. It involves separate data collection, preparation, and processing steps, resulting in a heterogeneous and fragmented process. To address these challenges, we present a comprehensive framework, HARE, which seamlessly integrates all necessary steps. HARE offers synchronized data collection and labeling, integrated pose estimation for data anonymization, a multimodal classification approach, and a novel method for determining optimal sensor placement to enhance classification results. Additionally, our framework incorporates real-time activity recognition with on-device model adaptation capabilities. To validate the effectiveness of our framework, we conducted extensive evaluations using diverse datasets, including our own collected dataset focusing on nursing activities. Our results show that HARE’s multimodal and on-device trained model outperforms conventional single-modal and offline variants. Furthermore, our vision-based approach for optimal sensor placement yields comparable results to the trained model. Our work advances the field of sensor-based human activity recognition by introducing a comprehensive framework that streamlines data collection and classification while offering a novel method for determining optimal sensor placement. KW - human activity recognition KW - multimodal classification KW - privacy preservation KW - real-time classification KW - sensor placement Y1 - 2023 U6 - https://doi.org/10.3390/s23239571 SN - 1424-8220 VL - 23 IS - 23 PB - MDPI CY - Basel ER - TY - JOUR A1 - Sixtus, Elena A1 - Lindner, Nadja A1 - Lohse, Karoline A1 - Lonnemann, Jan T1 - Investigating the influence of body movements on children's mental arithmetic performance JF - Acta psychologica : international journal of psychonomics N2 - Several lines of research have demonstrated spatial-numerical associations in both adults and children, which are thought to be based on a spatial representation of numerical information in the form of a mental number line. The acquisition of increasingly precise mental number line representations is assumed to support arithmetic learning in children. It is further suggested that sensorimotor experiences shape the development of number concepts and arithmetic learning, and that mental arithmetic can be characterized as “motion along a path” and might constitute shifts in attention along the mental number line. The present study investigated whether movements in physical space influence mental arithmetic in primary school children, and whether the expected effect depends on concurrency of body movements and mental arithmetic. After turning their body towards the left or right, 48 children aged 8 to 10 years solved simple subtraction and addition problems. Meanwhile, they either walked or stood still and looked towards the respective direction. We report a congruency effect between body orientation and operation type, i.e., higher performance for the combinations leftward orientation and subtraction and rightward orientation and addition. We found no significant difference between walking and looking conditions. The present results suggest that mental arithmetic in children is influenced by preceding sensorimotor cues and not necessarily by concurrent body movements. KW - Mental number line KW - Horizontal space KW - Embodied cognition KW - Arithmetic skills Y1 - 2023 U6 - https://doi.org/10.1016/j.actpsy.2023.104003 SN - 0001-6918 SN - 1873-6297 VL - 239 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Moreno Curtidor, Catalina A1 - Annunziata, Maria Grazia A1 - Gupta, Saurabh A1 - Apelt, Federico A1 - Richard, Sarah Isabel A1 - Kragler, Friedrich A1 - Müller-Röber, Bernd A1 - Olas, Justyna Jadwiga T1 - Physiological profiling of embryos and dormant seeds in two Arabidopsis accessions reveals a metabolic switch in carbon reserve accumulation JF - Frontiers in plant science N2 - In flowering plants, sugars act as carbon sources providing energy for developing embryos and seeds. Although most studies focus on carbon metabolism in whole seeds, knowledge about how particular sugars contribute to the developmental transitions during embryogenesis is scarce. To develop a quantitative understanding of how carbon composition changes during embryo development, and to determine how sugar status contributes to final seed or embryo size, we performed metabolic profiling of hand-dissected embryos at late torpedo and mature stages, and dormant seeds, in two Arabidopsis thaliana accessions with medium [Columbia-0 (Col-0)] and large [Burren-0 (Bur-0)] seed sizes, respectively. Our results show that, in both accessions, metabolite profiles of embryos largely differ from those of dormant seeds. We found that developmental transitions from torpedo to mature embryos, and further to dormant seeds, are associated with major metabolic switches in carbon reserve accumulation. While glucose, sucrose, and starch predominantly accumulated during seed dormancy, fructose levels were strongly elevated in mature embryos. Interestingly, Bur-0 seeds contain larger mature embryos than Col-0 seeds. Fructose and starch were accumulated to significantly higher levels in mature Bur-0 than Col-0 embryos, suggesting that they contribute to the enlarged mature Bur-0 embryos. Furthermore, we found that Bur-0 embryos accumulated a higher level of sucrose compared to hexose sugars and that changes in sucrose metabolism are mediated by sucrose synthase (SUS), with SUS genes acting non-redundantly, and in a tissue-specific manner to utilize sucrose during late embryogenesis. KW - carbon KW - embryo development KW - hexoses KW - metabolites KW - sucrose KW - synthase Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2020.588433 SN - 1664-462X VL - 11 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Kühne, Franziska T1 - Assessing patient preferences BT - examination of the german cooper-norcross inventory of preferences JF - Frontiers in psychology N2 - Despite the positive effects of including patients' preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. KW - psychotherapy KW - preference KW - activity preference KW - preference assessment KW - validation study Y1 - 2022 U6 - https://doi.org/10.3389/fpsyg.2021.795776 SN - 1664-1078 VL - 12 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Gisch, Ulrike Alexandra A1 - Robert, Margaux A1 - Berlin, Noemi A1 - Nebout, Antoine A1 - Etile, Fabrice A1 - Teyssier, Sabrina A1 - Andreeva, Valentina A. A1 - Hercberg, Serge A1 - Touvier, Mathilde A1 - Peneau, Sandrine T1 - Mastery is associated with weight status, food intake, snacking, and eating disorder symptoms in the NutriNet-Sante cohort study JF - Frontiers in Nutrition N2 - Mastery is a psychological resource that is defined as the extent to which individuals perceive having control over important circumstances of their lives. Although mastery has been associated with various physical and psychological health outcomes, studies assessing its relationship with weight status and dietary behavior are lacking. The aim of this cross-sectional study was to assess the relationship between mastery and weight status, food intake, snacking, and eating disorder (ED) symptoms in the NutriNet-Sante cohort study. Mastery was measured with the Pearlin Mastery Scale (PMS) in 32,588 adults (77.45% female), the mean age was 50.04 (14.53) years. Height and weight were self-reported. Overall diet quality and food group consumption were evaluated with >= 3 self-reported 24-h dietary records (range: 3-27). Snacking was assessed with an ad-hoc question. ED symptoms were assessed with the Sick-Control-One-Fat-Food Questionnaire (SCOFF). Linear and logistic regression analyses were conducted to assess the relationship between mastery and weight status, food intake, snacking, and ED symptoms, controlling for sociodemographic and lifestyle characteristics. Females with a higher level of mastery were less likely to be underweight (OR: 0.88; 95%CI: 0.84, 0.93), overweight [OR: 0.94 (0.91, 0.97)], or obese [class I: OR: 0.86 (0.82, 0.90); class II: OR: 0.76 (0.71, 0.82); class III: OR: 0.77 (0.69, 0.86)]. Males with a higher level of mastery were less likely to be obese [class III: OR: 0.75 (0.57, 0.99)]. Mastery was associated with better diet quality overall, a higher consumption of fruit and vegetables, seafood, wholegrain foods, legumes, non-salted oleaginous fruits, and alcoholic beverages and with a lower consumption of meat and poultry, dairy products, sugary and fatty products, milk-based desserts, and sweetened beverages. Mastery was also associated with lower snacking frequency [OR: 0.89 (0.86, 0.91)] and less ED symptoms [OR: 0.73 (0.71, 0.75)]. As mastery was associated with favorable dietary behavior and weight status, targeting mastery might be a promising approach in promoting healthy behaviors. KW - mastery KW - locus of control KW - weight status KW - diet quality KW - food group consumption KW - snacking KW - eating disorder symptoms KW - large population Y1 - 2022 U6 - https://doi.org/10.3389/fnut.2022.871669 SN - 2296-861X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - CHAP A1 - Marx, Julian A1 - Brünker, Felix A1 - Mirbabaie, Milad A1 - Stieglitz, Stefan ED - Bui, Tung X. T1 - Digital activism on social media BT - the role of brand ambassadors and corporate reputation management T2 - Proceedings of the 57th Annual Hawaii International Conference on System Sciences N2 - Social media constitute an important arena for public debates and steady interchange of issues relevant to society. To boost their reputation, commercial organizations also engage in political, social, or environmental debates on social media. To engage in this type of digital activism, organizations increasingly utilize the social media profiles of executive employees and other brand ambassadors. However, the relationship between brand ambassadors’ digital activism and corporate reputation is only vaguely understood. The results of a qualitative inquiry suggest that digital activism via brand ambassadors can be risky (e.g., creating additional surface for firestorms, financial loss) and rewarding (e.g., emitting authenticity, employing ‘megaphones’ for industry change) at the same time. The paper informs both scholarship and practitioners about strategic trade-offs that need to be considered when employing brand ambassadors for digital activism. KW - the bright and dark side of social media in the marginalized contexts KW - brand ambassadors KW - digital activism KW - reputation management KW - social media Y1 - 2024 UR - https://hdl.handle.net/10125/107250 SN - 978-0-99813-317-1 SP - 7205 EP - 7214 PB - Department of IT Management Shidler College of Business University of Hawaii CY - Honolulu, HI ER - TY - JOUR A1 - Philipowski, Katharina T1 - Konrads ›Klage der Kunst‹ im Kontext von Sangspruchdichtung und allegorischem Ich-Erzählen JF - Konrad von Würzburg als Erzähler JF - Beiträge zur mediävistischen Erzählforschung N2 - Die ›Klage der Kunst‹ Konrads wird auf dem Hintergrund und in Bezug zur Sangspruchdichtung sowie der Textfamilie allegorischer Erzählungen in der ersten Person untersucht. Während Strophik, Sangbarkeit und kunst-Thematik das Werk in den Kontext der Sangspruchdichtung rücken, stellt es sich durch seinen Umfang, seine Narrativität und das Erzähltempus, das die Handlung zwar nicht dominiert, aber rahmt, an die Seite erster früher Erzählexperimente, die Dialog, Streit oder Rede als erlebte Erfahrung eines Ich präsentieren wie das ›Frauenbuch‹ Ulrichs von Liechtenstein, das aber – ähnlich wie Konrads ›Klage der Kunst‹ – zu seiner Zeit offenbar nur mäßig erfolgreich, jedenfalls nur unikal überliefert, ist. Konrad scheint der erste zu sein, der in der höfischen Literatur das Erzählen in der ersten Person mit Allegorizität verknüpft. Er nutzt dieses neue und in der späteren Literatur so überaus fruchtbare Erzählformat geschickt, um seine eigene literarische Meisterschaft unter anderem in den Gestalten von wildekeit und kunst unter Beweis zu stellen, zu thematisieren und szenisch zu verhandeln. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?https://ojs.uni-oldenburg.de/ojs/index.php/bme/article/view/131 SN - 2568-9967 VL - 10 IS - Themenheft SP - 57 EP - 79 PB - University of Oldenburg Press CY - Oldenburg ER - TY - CHAP A1 - Mirbabaie, Milad A1 - Rieskamp, Jonas A1 - Hofeditz, Lennart A1 - Stieglitz, Stefan ED - Bui, Tung X. T1 - Breaking down barriers BT - how conversational agents facilitate open science and data sharing T2 - Proceedings of the 57th Annual Hawaii International Conference on System Sciences N2 - Many researchers hesitate to provide full access to their datasets due to a lack of knowledge about research data management (RDM) tools and perceived fears, such as losing the value of one's own data. Existing tools and approaches often do not take into account these fears and missing knowledge. In this study, we examined how conversational agents (CAs) can provide a natural way of guidance through RDM processes and nudge researchers towards more data sharing. This work offers an online experiment in which researchers interacted with a CA on a self-developed RDM platform and a survey on participants’ data sharing behavior. Our findings indicate that the presence of a guiding and enlightening CA on an RDM platform has a constructive influence on both the intention to share data and the actual behavior of data sharing. Notably, individual factors do not appear to impede or hinder this effect. KW - open science practices in information systems research KW - conversational agents KW - data sharing KW - digital nudging KW - open science KW - research data management Y1 - 2024 UR - https://hdl.handle.net/10125/106457 SN - 978-0-99813-317-1 SP - 672 EP - 681 PB - Department of IT Management Shidler College of Business University of Hawaii CY - Honolulu, HI ER - TY - JOUR A1 - Reil, Daniela A1 - Rosenfeld, Ulrike A1 - Imholt, Christian A1 - Schmidt, Sabrina A1 - Ulrich, Rainer G. A1 - Eccard, Jana A1 - Jacob, Jens T1 - Puumala hantavirus infections in bank vole populations BT - host and virus dynamics in Central Europe JF - BMC ecology N2 - Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010–2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk KW - Myodes glareolus KW - Population dynamics KW - Puumala virus seroprevalence KW - Space use KW - Survival Y1 - 2017 U6 - https://doi.org/10.1186/s12898-017-0118-z SN - 1472-6785 VL - 17 PB - BioMed Central CY - London ER - TY - JOUR A1 - Kraft, Tobias ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - Neue Quellen zu Humboldts Kuba-Forschung. Das „Digitale Dossier“ des Proyecto Humboldt Digital (2019–2023) JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - Die deutsch-kubanische Forschungs- und Digitalisierungsinitiative „Proyecto Humboldt Digital“ (ProHD) hat während ihrer Projektlaufzeit (2019–2023) wichtige Quellen zum Thema „Humboldt und Kuba“ erstmals digital erschlossen. Als Kooperation zwischen der Berlin-Brandenburgischen Akademie der Wissenschaften und der Oficina del Historiador de la Ciudad de La Habana hat ProHD damit wichtige Akzente für die Archivdigitalisierung, die digitale Editionsphilologie und die digitale Wissenschaftskommunikation in Kuba gesetzt. Das Korpus der erschlossenen Bestände wird hier in fünf Schlaglichtern vorgestellt: 1) Quellen zur Humboldt’schen Forschungsreise, 2) Juan Luis de la Cuesta, 3) Materialien zu Kuba aus dem Humboldt-Nachlass, 4) Zensur und Beschlagnahme des Essai politique sur l’île de Cuba, 5) Francisco de Arango y Parreño. N2 - La iniciativa alemana-cubana “Proyecto Humboldt Digital” (ProHD) ha hecho accesibles digitalmente por primera vez importantes fuentes sobre el tema “Humboldt y Cuba” durante el período de su ejecución (2019–2023). Como cooperación entre la Academia de Ciencias y Humanidades de Berlín-Brandeburgo y la Oficina del Historiador de la Ciudad de La Habana, ProHD ha inspirado importantes pautas para la digitalización de archivos, la ecdótica digital y la comunicación científica digital en Cuba. El corpus de los fondos catalogados se presenta aquí en cinco puntos destacados: 1) fuentes en torno al viaje humboldtiano, 2) Juan Luis de la Cuesta, 3) materiales sobre Cuba de la colección Humboldt, 4) Censura y confiscación del Essai politique sur l’île de Cuba, 5) Francisco de Arango y Parreño. N2 - The German-Cuban initiative “Proyecto Humboldt Digital” (ProHD) has made important archival sources on “Humboldt and Cuba” digitally accessible for the first time during the project period (2019–2023). As a cooperation between the Berlin-Brandenburg Academy of Sciences and Humanities and the Office of the Historian of the City of Havana, ProHD has inspired key principles for archival digitization, digital scholarly editions and digital scholarly communication in Cuba. The digital corpus is presented in this article along five main strands: 1) documents related to Humboldt’s voyage, 2) Juan Luis de la Cuesta, 3) Documents on Cuba from the Humboldt personal papers, 4) censorship and confiscation of the Essai politique sur l’île de Cuba, 5) Francisco de Arango y Parreño. KW - digitale Geisteswissenschaften KW - Kuba KW - Editionsphilologie KW - Humboldt-Nachlass KW - Essai politique sur l’île de Cuba Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-646592 SN - 2568-3543 SN - 1617-5239 VL - XXV IS - 48 SP - 25 EP - 64 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Gao, Hong ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - Nachgedanken zur Übersetzung des ersten Bandes von Humboldts „Kosmos“ JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - La traduction en langue chinoise du premier volume du monumental ouvrage scientifique d'Alexander von Humboldt, intitulé «Cosmos», a vu le jour en 2023 sous l՚égide de la prestigieuse maison d՚édition de l՚Université de Pékin. Dans sa postface éclairée, la traductrice émérite, Gao Hong, éclaire la lanterne des lecteurs chinois sur la fresque cosmique esquissée par Humboldt, révélant ainsi les intrications entre les phénomènes naturels et leur pertinence à l՚échelle de l'univers tout entier. Gao Hong narre son propre périple aux côtés de Humboldt, tout en distillant ses réflexions personnelles sur cette fresque cosmique. «Cosmos» d՚Humboldt, œuvre scientifique par excellence, transcende également les sphères esthétiques et artistiques, exprimant invariablement une profonde vénération pour l՚univers. Restituer en chinois la «beauté géométrique» de la langue allemande, empreinte d՚une rigueur structurelle, constitue un défi singulier, le chinois se caractérisant par sa fluidité, sa souplesse et sa poésie imagée, en totale antithèse avec l՚allemand. En qualité de traducteur, il importe de naviguer librement entre ces deux mondes linguistiques distincts. N2 - In 2023, the first translation of Alexander von Humboldt՚s work “Kosmos”, Volume I, into Chinese was published by Peking University Press. In the afterword, translated here into German, translator Gao Hong familiarizes Chinese readers with the characteristics of Humboldt՚s “description of the world,” which presents natural phenomena in their interrelationships and their connection with the universe as a whole. Gao Hong describes her own journey in Humboldt՚s footsteps and her fascination with this nature painting, which also meets the highest aesthetic standards and is designed to promote awe towards the cosmos. Transmitting the “geometric beauty” of this language is a particular challenge because the flowing, pictorial structure of Chinese is almost contrary to the strict regulations of German. As a translator you have to move freely between the two worlds. N2 - 亚里山大·洪堡的科学巨著《宇宙》第一卷的中文译本于2023年由北京大学出版社出版。在译后记中，译者高虹向中国读者介绍了洪堡笔下的宇宙画卷，这幅画卷展示出自然现象之间的相互关系以及它们与整个宇宙的相关性。高虹讲述了自己追随洪堡的旅程以及她个人对这幅宇宙画卷的欣赏与思考。洪堡的《宇宙》是一部科学著作，但同时也呈现出极高的美学境界与水准，它无处不在表达对宇宙的敬畏。在中文翻译中再现德语语言拥有严谨结构的“几何美”是一个特殊的挑战，因为汉语流畅，灵动，充满意境之美，与德语的特点完全相反。作为译者必须要在两个语言世界之间自由转换。 KW - Kosmos KW - Zusammenhänge der Naturerscheinungen und deren Wechselwirkungen auf einander KW - Ehrfurcht vor Kosmos KW - architektonische Schönheit der Humboldt’schen Sprache Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-646569 SN - 2568-3543 SN - 1617-5239 VL - XXV IS - 48 SP - 17 EP - 24 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ette, Ottmar A1 - Schwarz, Ingo ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - „Ein junges, neues Geschlecht wird besseres liefern als das alte“. Ein Empfehlungsbrief Alexander von Humboldts für Carl Ludwig JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - In dem Aufsatz wird ein Brief erstmalig veröffentlicht, in dem Alexander von Humboldt im Jahr 1849 bei einem Minister der liberalen Regierung von Kurhessen die Verdienste eines an der Universität in Marburg lehrenden jungen Professors hervorhob. Die Rede ist hier von dem später durch bahnbrechende Entdeckungen berühmten Physiologen Carl Ludwig. Vermittelt wurde das Schreiben durch den Humboldt nahestehenden Mediziner und Physiologen Emil du Bois-Reymond. Der Empfehlungsbrief, mit dem Humboldt versuchte, Ludwigs finanzielle Situation zu verbessern, ist ein Beispiel für die Förderung junger Forscher wie auch freier wissenschaftlicher Institutionen durch Humboldt. N2 - A letter from Alexander von Humboldt to a minister in the liberal government of the Electorate of Hesse is published here for the first time. In this letter from 1849, Humboldt praised the achievements of a young professor at the University of Marburg: Carl Ludwig, now famous for his groundbreaking discoveries in physiology. Humboldt’s friend and colleague, Emil du Bois-Reymond, had facilitated the contact between Ludwig and Humboldt. The letter of recommendation, with which Humboldt sought to help improve Ludwig’s financial situation, is an example of how Humboldt promoted the work of young scientists and independent scientific institutions. N2 - En el ensayo se publica por primera vez una carta en la que Alexander von Humboldt, en 1849, enfatizaba los méritos de un joven profesor que enseñaba en la Universidad de Marburg a un ministro del gobierno liberal de Hesse. Estamos hablando del fisiólogo Carl Ludwig, que más tarde se hizo famoso por sus descubrimientos innovadores. La carta fue mediada por el médico y fisiólogo Emil du Bois-Reymond, cercano a Humboldt. La carta de recomendación con la que Humboldt intentó mejorar la situación financiera de Ludwig es un ejemplo del apoyo de Humboldt a los jóvenes investigadores y a las instituciones científicas independientes. KW - Alexander von Humboldt KW - Förderung junger Wissenschaftler KW - Carl Ludwig KW - Emil du Bois-Reymond KW - Kurhessen KW - Bernhard Eberhard KW - Physiologie Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-646552 SN - 2568-3543 SN - 1617-5239 VL - XXV IS - 48 SP - 5 EP - 15 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kutzinski, Vera M. ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - Off-road adventures BT - reading statistics in Alexander von Humboldt’s political essay on the kingdom of New Spain JF - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies N2 - This article focuses on the visual qualities of Alexander von Humboldt’s statistical tables in his Political Essay on the Kingdom of New Spain (1808–1811, 2nd ed. 1825–1827) with special attention to how such composites of numbers, alphabetical script, and semiotic elements relate to narrative writing. I argue that Humboldt’s tables/tableaus open up spaces inside his narrative that fragment the reading process, inviting new conversations, connections, and ideas. N2 - Este articulo entretiene con los atributos visuales de las abundantes tablas estadísticas incluyendo en el Essai politique sur le royaume de la Nouvelle Espagne (1808–1811, 2nd ed. 1825–1827) de Alexander de Humboldt, en especial con las relaciones entre las combinaciones de números, escritura y elementos semióticos (que Humboldt llama “tableaux”) y la propia narrativa. Obran estas relaciones una fragmentación del proceso de leer, abriendo dimensiones y espacios en que se podrían manifestar nuevas conexiones, conversaciones e ideas innovadoras. N2 - Dieser Artikel befasst sich mit den bildhaften Eigenschaften der vielen statistischen Tabellen in Alexander von Humboldts Essai politique sur le royaume de la Nouvelle Espagne (1808–1811, 2nd ed. 1820–1827), wobei meine besondere Aufmerksamkeit den Verhältnissen gilt, die diese aus Zahlen, alphabetischer Schrift und semiotischen Elementen zusammengesetzten Komposita (die Humboldt als Tableaux bezeichnet) mit der beschreibenden Erzählung selbst eingehen: In diesen Verhältnissen offenbaren sich nämlich Dimensionen oder Räumlichkeiten, die durch die visuelle Zerteilung des Textes stets weitere, neue Verbindungen, Gespräche und Ideen zu produzieren suchen. KW - statistics KW - visuality and narrative KW - word-image relations KW - New Spain Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-646601 SN - 2568-3543 SN - 1617-5239 VL - XXV IS - 48 SP - 65 EP - 86 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kretzschmar, Mirjam E. A1 - Ashby, Ben A1 - Fearon, Elizabeth A1 - Overton, Christopher E. A1 - Panovska-Griffiths, Jasmina A1 - Pellis, Lorenzo A1 - Quaife, Matthew A1 - Rozhnova, Ganna A1 - Scarabel, Francesca A1 - Stage, Helena B. A1 - Swallow, Ben A1 - Thompson, Robin N. A1 - Tildesley, Michael J. A1 - Villela, Daniel Campos T1 - Challenges for modelling interventions for future pandemics JF - Epidemics N2 - Mathematical modelling and statistical inference provide a framework to evaluate different non-pharmaceutical and pharmaceutical interventions for the control of epidemics that has been widely used during the COVID-19 pandemic. In this paper, lessons learned from this and previous epidemics are used to highlight the challenges for future pandemic control. We consider the availability and use of data, as well as the need for correct parameterisation and calibration for different model frameworks. We discuss challenges that arise in describing and distinguishing between different interventions, within different modelling structures, and allowing both within and between host dynamics. We also highlight challenges in modelling the health economic and political aspects of interventions. Given the diversity of these challenges, a broad variety of interdisciplinary expertise is needed to address them, combining mathematical knowledge with biological and social insights, and including health economics and communication skills. Addressing these challenges for the future requires strong cross disciplinary collaboration together with close communication between scientists and policy makers. KW - Mathematical models KW - Pandemics KW - Pharmaceutical interventions KW - Non-pharmaceutical interventions KW - Policy support Y1 - 2022 U6 - https://doi.org/10.1016/j.epidem.2022.100546 SN - 1755-4365 SN - 1878-0067 VL - 38 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Bilgen, Isa T1 - Our dignity in your hands T2 - Verfassungsblog : on matters constitutional Y1 - 2024 UR - https://verfassungsblog.de/our-dignity-in-your-hands/ U6 - https://doi.org/10.17176/20240204-004255-0 SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - JOUR A1 - van Rees, Charles B. A1 - Waylen, Kerry A. A1 - Schmidt-Kloiber, Astrid A1 - Thackeray, Stephen J. A1 - Kalinkat, Gregor A1 - Martens, Koen A1 - Domisch, Sami A1 - Lillebo, Ana A1 - Hermoso, Virgilio A1 - Grossart, Hans-Peter A1 - Schinegger, Rafaela A1 - Decleer, Kris A1 - Adriaens, Tim A1 - Denys, Luc A1 - Jaric, Ivan A1 - Janse, Jan H. A1 - Monaghan, Michael T. A1 - De Wever, Aaike A1 - Geijzendorffer, Ilse A1 - Adamescu, Mihai C. A1 - Jähnig, Sonja C. T1 - Safeguarding freshwater life beyond 2020 BT - recommendations for the new global biodiversity framework from the European experience JF - Conservation letters N2 - Plans are currently being drafted for the next decade of action on biodiversity-both the post-2020 Global Biodiversity Framework of the Convention on Biological Diversity (CBD) and Biodiversity Strategy of the European Union (EU). Freshwater biodiversity is disproportionately threatened and underprioritized relative to the marine and terrestrial biota, despite supporting a richness of species and ecosystems with their own intrinsic value and providing multiple essential ecosystem services. Future policies and strategies must have a greater focus on the unique ecology of freshwater life and its multiple threats, and now is a critical time to reflect on how this may be achieved. We identify priority topics including environmental flows, water quality, invasive species, integrated water resources management, strategic conservation planning, and emerging technologies for freshwater ecosystem monitoring. We synthesize these topics with decades of first-hand experience and recent literature into 14 special recommendations for global freshwater biodiversity conservation based on the successes and setbacks of European policy, management, and research. Applying and following these recommendations will inform and enhance the ability of global and European post-2020 biodiversity agreements to halt and reverse the rapid global decline of freshwater biodiversity. KW - climate change KW - conservation KW - ecosystem services KW - rivers KW - sustainable KW - development goals KW - water resources KW - wetlands Y1 - 2020 U6 - https://doi.org/10.1111/conl.12771 SN - 1755-263X VL - 14 IS - 1 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Perkins, Anita A1 - Rose, Andrew A1 - Grossart, Hans-Peter A1 - Rojas-Jimenez, Keilor Osvaldo A1 - Barroso Prescott, Selva Kiri A1 - Oakes, Joanne M. T1 - Oxic and Anoxic Organic Polymer Degradation Potential of Endophytic Fungi From the Marine Macroalga, Ecklonia radiata JF - Frontiers in Microbiology N2 - Cellulose and chitin are the most abundant polymeric, organic carbon source globally. Thus, microbes degrading these polymers significantly influence global carbon cycling and greenhouse gas production. Fungi are recognized as important for cellulose decomposition in terrestrial environments, but are far less studied in marine environments, where bacterial organic matter degradation pathways tend to receive more attention. In this study, we investigated the potential of fungi to degrade kelp detritus, which is a major source of cellulose in marine systems. Given that kelp detritus can be transported considerable distances in the marine environment, we were specifically interested in the capability of endophytic fungi, which are transported with detritus, to ultimately contribute to kelp detritus degradation. We isolated 10 species and two strains of endophytic fungi from the kelp Ecklonia radiata. We then used a dye decolorization assay to assess their ability to degrade organic polymers (lignin, cellulose, and hemicellulose) under both oxic and anoxic conditions and compared their degradation ability with common terrestrial fungi. Under oxic conditions, there was evidence that Ascomycota isolates produced cellulose-degrading extracellular enzymes (associated with manganese peroxidase and sulfur-containing lignin peroxidase), while Mucoromycota isolates appeared to produce both lignin and cellulose-degrading extracellular enzymes, and all Basidiomycota isolates produced lignin-degrading enzymes (associated with laccase and lignin peroxidase). Under anoxic conditions, only three kelp endophytes degraded cellulose. We concluded that kelp fungal endophytes can contribute to cellulose degradation in both oxic and anoxic environments. Thus, endophytic kelp fungi may play a significant role in marine carbon cycling via polymeric organic matter degradation. KW - kelp KW - fungi KW - endophytes KW - carbon cycling KW - extracellular enzymes KW - cellulose polymeric organic matter Y1 - 2021 U6 - https://doi.org/10.3389/fmicb.2021.726138 SN - 1664-302X VL - 12 SP - 1 EP - 13 PB - Frontiers in microbiology CY - Lausanne, Schweiz ER - TY - GEN A1 - Philipowski, Katharina ED - Philipowski, Katharina T1 - Experience and poetology in allegorical love autobiographies BT - an introduction into the volume T2 - Medieval Forms of First-Person Narration: A Potentially Universal Format (Villa Vigoni Talks I) T2 - Beiträge zur mediävistischen Erzählforschung N2 - Im Hochmittelalter entstehen Erzählungen, die etablierte literarische Formen und Traditionen neu verbinden: Sie sind volkssprachig, allegorisch und verwenden als Erzählform die erste Person, um in dieser Kombination, die sich zu einem die Grenzen der Einzelsprachen überschreitenden Erzähl-Format verfestigt, unterschiedlichste Themen aufzugreifen. Dieses Format, erstmals realisiert im altfranzösischen Roman de la Rose, wird die europäische Literatur mit Texten wie Dantes Divina Comedia, Guillaumes de Deguileville Pèlerinage de la Vie Humaine, William Langlands Pierce Plowman und Christines de Pizan Le Livre de la mutation de Fortune bis weit in die Neuzeit hinein prägen. Der in den Band einleitende Beitrag geht der Frage nach, ob das narrative Format dabei universell verwendet wird oder, z.B. im Rahmen der Liebesdichtung, spezifische Besonderheiten aufweist. KW - Mediävistik KW - Erzählforschung Y1 - 2020 U6 - https://doi.org/10.25619/BmE2020375 SN - 2568-9967 VL - 8 IS - Special Issue SP - 1 EP - 27 PB - University of Oldenburg Press CY - Oldenburg ER - TY - JOUR ED - Philipowski, Katharina T1 - Medieval forms of first-person narration I BT - a potentially universal format (Villa Vigoni Talks I) T2 - Beiträge zur mediävistischen Erzählforschung N2 - In many European vernacular literatures in the 13th and 16th centuries, texts with remarkable congruities clearly emerge. They are allegorical, their subject is worldly love, and they use the first person as their narrative form. The most popular would be the French ›Roman de la Rose‹, the Italian ›Vita Nuova‹ by Dante or the Spanish ›Libro de buen amor‹. German examples are the ›Minnelehre‹ by Johann of Constance or the anonymous ›Minneburg‹. Until now such texts have been classified as (Dream-) allegories, as courtly love (Minne) speeches, or also as (fictional or stylized) autobiographies. As a result, they have rarely, if ever, been compared with each other. The goal of our conferences is to facilitate interdisciplinary exchanges regarding these texts, especially as concerns poetological, narrative, and allegorical dimensions. KW - Mediävistik KW - Erzählforschung Y1 - 2020 U6 - https://doi.org/10.25619/BmE_H202038 SN - 2568-9967 VL - 8 IS - Special Issue PB - University of Oldenburg Press CY - Oldenburg ER - TY - GEN A1 - Bilgen, Isa T1 - Unsere Würde in Euren Händen T2 - Verfassungsblog : on matters constitutional Y1 - 2024 UR - https://verfassungsblog.de/unsere-wurde-in-euren-handen/ U6 - https://doi.org/10.17176/20240204-004217-0 SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - JOUR A1 - Denz, Rebekka A1 - Stellmacher, Martha A1 - Ullrich, Rebecca T1 - Einleitung JF - Genisa-Blätter IV Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-584843 SN - 978-3-86956-539-2 SP - 9 EP - 13 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - CHAP A1 - Peppler, Lisa A1 - Feißt, Martin A1 - Schneider, Anna A1 - Apelt, Maja A1 - Schenk, Liane T1 - Beyond one-sided expectations of integration BT - rethinking international nurse migration to Germany T2 - European journal of public health N2 - Background: Like most countries, Germany is currently recruiting international nurses due to staff shortages. While these are mostly academic, the academisation of nursing in Germany has only just begun. This allows for a broader look at the participation of migrant nurses: How do care teams deal with the fact that immigrant colleagues are theoretically more highly qualified than long-established colleagues? Methods: Case studies were conducted in four inpatient care teams of two hospitals in 2022. Qualitative data include 26 observation protocols, 4 group discussions and 17 guided interviews. These were analysed using the documentary method and validated intersubjectively. Results: Due to current academisation efforts in Germany and the immigration of academised nursing staff from abroad, the areas of activity and responsibility of nursing in Germany are under negotiating pressure. This concerns basic care for example, which in Germany is provided by skilled workers, but in other countries is mostly provided by assistants or relatives. The question of who should provide basic care, whether all nurses or only nursing assistants, documents the struggle between an established and a new understanding of care. In this context, the knowledge and skills of migrant and academicised care workers become a crucial aspect in the struggle for a new professional identity for care in Germany. Conclusions: The specific situation in Germany makes it possible to show the potential for change that international care migration can constitute for destination countries. The far-reaching process of change of German nursing is given a further dimension not only by its academization, but by the immigration of international and academically trained nursing staff, where inclusive or exclusive effects can already be observed. Key messages: The increasing proportion of migrant nurses accelerates the current discussion on nursing in Germany. Conflict areas show up in everyday work of care teams and must be addressed there. KW - emigration and immigration KW - Germany KW - inpatients KW - negotiating KW - nurses KW - nursing staff KW - immigrants KW - professional identity Y1 - 2023 U6 - https://doi.org/10.1093/eurpub/ckad160.1484 SN - 1101-1262 SN - 1464-360X VL - 33 IS - Supplement 2 PB - Oxford University Press CY - London ER - TY - JOUR A1 - Bilgen, Isa ED - Ammann, Odile ED - Bottega, Fiona ED - Bukovac, Jasmina T1 - Verantwortungsvoller Parentalismus BT - Der Staat im Dienst der Selbstbestimmung JF - Verantwortung und Recht N2 - ndividuelle Selbstbestimmung ist Kernelement der Menschenwürde und damit ein Höchstwert der Verfassung. Dennoch scheint sich ihr Schutz auf die Abwesenheit des Staates zu beschränken. Tatsächlich ist sie zahlreichen Gefährdungen ausgesetzt. Der Beitrag will darum ihren Schutz auf das gebotene Niveau heben. Art. 1 Abs. 1 GG verpflichtet den Staat nicht nur zur Achtung, sondern auch zum Schutz der Menschenwürde. Will er diesen Auftrag ernstnehmen, muss er sich entsprechend in den Dienst der Selbstbestimmung seiner Bürger stellen. Dazu darf und muss er ihnen bisweilen Grenzen setzen, um ihre Verantwortungsfähigkeit zu fördern. Y1 - 2022 SN - 978-3-8487-8497-4 SN - 978-3-7489-2876-8 U6 - https://doi.org/10.5771/9783748928768-357 SP - 357 EP - 376 PB - Nomos CY - Baden-Baden ER - TY - JOUR A1 - González Hauck, Sué A1 - Herrmann, Franziska A1 - Hettihewa, Julian A. A1 - Kraft, Dariush A1 - Milas, Max A1 - Springer, Stephanie A1 - Weckner, Franka T1 - Jurisdiction BT - Who speaks international law? JF - Zeitschrift für ausländisches öffentliches Recht und Völkerrecht Y1 - 2022 UR - https://beck-online.beck.de/Bcid/Y-300-Z-ZAOERV-B-2022-S-289-N-1 U6 - https://doi.org/10.17104/0044-2348-2022-2-289 SN - 0044-2348 SN - 2942-3562 VL - 82 IS - 2 SP - 289 EP - 298 PB - C.H. Beck CY - München ER - TY - JOUR A1 - McHuron, Elizabeth A. A1 - Adamczak, Stephanie A1 - Arnould, John P. Y. A1 - Ashe, Erin A1 - Booth, Cormac A1 - Bowen, W. Don A1 - Christiansen, Fredrik A1 - Chudzinska, Magda A1 - Costa, Daniel P. A1 - Fahlman, Andreas A1 - Farmer, Nicholas A. A1 - Fortune, Sarah M. E. A1 - Gallagher, Cara A. A1 - Keen, Kelly A. A1 - Madsen, Peter T. A1 - McMahon, Clive R. A1 - Nabe-Nielsen, Jacob A1 - Noren, Dawn P. A1 - Noren, Shawn R. A1 - Pirotta, Enrico A1 - Rosen, David A. S. A1 - Speakman, Cassie N. A1 - Villegas-Amtmann, Stella A1 - Williams, Rob T1 - Key questions in marine mammal bioenergetics JF - Conservation physiology N2 - Bioenergetic approaches are increasingly used to understand how marine mammal populations could be affected by a changing and disturbed aquatic environment. There remain considerable gaps in our knowledge of marine mammal bioenergetics, which hinder the application of bioenergetic studies to inform policy decisions. We conducted a priority-setting exercise to identify high-priority unanswered questions in marine mammal bioenergetics, with an emphasis on questions relevant to conservation and management. Electronic communication and a virtual workshop were used to solicit and collate potential research questions from the marine mammal bioenergetic community. From a final list of 39 questions, 11 were identified as 'key'questions because they received votes from at least 50% of survey participants. Key questions included those related to energy intake (prey landscapes, exposure to human activities) and expenditure (field metabolic rate, exposure to human activities, lactation, time-activity budgets), energy allocation priorities, metrics of body condition and relationships with survival and reproductive success and extrapolation of data from one species to another. Existing tools to address key questions include labelled water, animal-borne sensors, mark-resight data from long-term research programs, environmental DNA and unmanned vehicles. Further validation of existing approaches and development of new methodologies are needed to comprehensively address some key questions, particularly for cetaceans. The identification of these key questions can provide a guiding framework to set research priorities, which ultimately may yield more accurate information to inform policies and better conserve marine mammal populations. Y1 - 2022 U6 - https://doi.org/10.1093/conphys/coac055 SN - 2051-1434 VL - 10 IS - 1 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Panzer, Marcel A1 - Bender, Benedict A1 - Gronau, Norbert T1 - Deep reinforcement learning in production planning and control BT - A systematic literature review T2 - Proceedings of the Conference on Production Systems and Logistics N2 - Increasingly fast development cycles and individualized products pose major challenges for today's smart production systems in times of industry 4.0. The systems must be flexible and continuously adapt to changing conditions while still guaranteeing high throughputs and robustness against external disruptions. Deep rein- forcement learning (RL) algorithms, which already reached impressive success with Google DeepMind's AlphaGo, are increasingly transferred to production systems to meet related requirements. Unlike supervised and unsupervised machine learning techniques, deep RL algorithms learn based on recently collected sensor- and process-data in direct interaction with the environment and are able to perform decisions in real-time. As such, deep RL algorithms seem promising given their potential to provide decision support in complex environments, as production systems, and simultaneously adapt to changing circumstances. While different use-cases for deep RL emerged, a structured overview and integration of findings on their application are missing. To address this gap, this contribution provides a systematic literature review of existing deep RL applications in the field of production planning and control as well as production logistics. From a performance perspective, it became evident that deep RL can beat heuristics significantly in their overall performance and provides superior solutions to various industrial use-cases. Nevertheless, safety and reliability concerns must be overcome before the widespread use of deep RL is possible which presumes more intensive testing of deep RL in real world applications besides the already ongoing intensive simulations. KW - deep reinforcement learning KW - machine learning KW - production planning KW - production control KW - systematic literature review Y1 - 2021 U6 - https://doi.org/10.15488/11238 SN - 2701-6277 SP - 535 EP - 545 PB - Institutionelles Repositorium der Leibniz Universität Hannover CY - Hannover ER - TY - BOOK A1 - Suter, Bernhard T1 - Gestaltungsprozesse im Musikunterricht anleiten BT - Eine Design-based-Research-Studie zur reflexionsgestützten Kompetenzentwicklung von berufseinsteigenden Primarlehrkräften BT - A design-based research study on the reflection-supported competence development of primary school teachers entering the profession T3 - Potsdamer Schriftenreihe zur Musikpädagogik N2 - «Musik erfinden und gestalten» hat grosses musikpädagogisches Potenzial: mit Klängen experimentieren, ein Gespür für dramaturgische Verläufe entwickeln, nonverbal kommunizieren – Musik erfinden und gestalten eröffnet ein breites Feld musikalischer Aktivitäten und Erfahrungsmöglichkeiten. Doch im regulären Musikunterricht in der Volksschule der Schweiz sind produktionsdidaktische Ansätze noch eher die Ausnahme und Musiklehrkräften fehlt es an Anleitungsstrategien. Für das vorliegende Buch untersuchte der Autor in Form einer Design-based-Research-Studie, wie Primarlehrkräfte ihre Anleitungsstrategien bei der Durchführung von musikalischen Gestaltungsprozessen in ihren Schulklassen schrittweise entwickeln. Dabei begleitete der Forscher die Lehrkräfte in der schulischen Praxis und intervenierte gezielt mit Reflexionsimpulsen, um den Professionalisierungsprozess zu unterstützen. Daraus wurden drei Reflexionstools generiert: Das Reflexionstool try-outs beinhaltet konkrete Handlungsanregungen und Reflexionsfragen für das Anleiten musikalischer Gestaltungsprozesse. Das Onlinetool improspider ist ein Selbstreflexionsinstrument zur Einschätzung personaler Orientierungen. Das Kompetenzmodell Kompetenzflyer bietet eine Reflexionsfolie für die Ansteuerung eigenständiger Kompetenzerwerbsschritte. Die Reflexionstools sind außerdem online in Form eines Lernobjekts verfügbar. N2 - “Inventing and creating music” has great potential for music education: experimenting with sounds, developing a feel for dramaturgical progressions, communicating non-verbally - inventing and creating music opens up a broad field of musical activities and experiential possibilities. However, in regular music lessons in Swiss elementary school, didactic approaches to production are still the exception rather than the rule and music teachers lack guidance strategies. For this book, the author used a design-based research study to investigate how primary school teachers gradually develop their instruction strategies when carrying out musical creation processes in their classrooms. The researcher accompanied the teachers in their school practice and intervened specifically with reflection impulses to support the professionalization process. Three reflection tools were generated from this: The reflection tool “try-outs” contains concrete suggestions for action and reflection questions for guiding musical design processes. The online tool “improspider” is a self-reflection instrument for assessing personal orientation. The competence model “competence flyer” offers a reflection foil for the control of independent competence acquisition steps. The reflection tools are also available online in the form of a learning object. T2 - Guiding creative processes in music lessons T3 - Potsdamer Schriftenreihe zur Musikpädagogik - 10 KW - Musikunterricht auf Primarstufe KW - musikalische Gestaltungsprozesse KW - Fachdidaktik Musik KW - Lehrerbildung KW - Design-based Research KW - music teaching at primary level KW - inventing music KW - didactics of music KW - teacher training KW - design-based research Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-600523 SN - 978-3-86956-567-5 SN - 1861-8529 SN - 2196-5080 IS - 10 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Dellepiane, Sergio A1 - Vaid, Akhil A1 - Jaladanki, Suraj K. A1 - Coca, Steven A1 - Fayad, Zahi A. A1 - Charney, Alexander W. A1 - Böttinger, Erwin A1 - He, John Cijiang A1 - Glicksberg, Benjamin S. A1 - Chan, Lili A1 - Nadkarni, Girish T1 - Acute kidney injury in patients hospitalized with COVID-19 in New York City BT - temporal trends From March 2020 to April 2021 JF - Kidney medicine Y1 - 2021 U6 - https://doi.org/10.1016/j.xkme.2021.06.008 SN - 2590-0595 VL - 3 IS - 5 SP - 877 EP - 879 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kowalczyk, Katarzyna A. A1 - Amann, Thorben A1 - Strefler, Jessica A1 - Vorrath, Maria-Elena A1 - Hartmann, Jens A1 - de Marco, Serena A1 - Renforth, Phil A1 - Foteinis, Spyros A1 - Kriegler, Elmar T1 - Marine carbon dioxide removal by alkalinization should no longer be overlooked JF - Environmental research letters N2 - To achieve the Paris climate target, deep emissions reductions have to be complemented with carbon dioxide removal (CDR). However, a portfolio of CDR options is necessary to reduce risks and potential negative side effects. Despite a large theoretical potential, ocean-based CDR such as ocean alkalinity enhancement (OAE) has been omitted in climate change mitigation scenarios so far. In this study, we provide a techno-economic assessment of large-scale OAE using hydrated lime ('ocean liming'). We address key uncertainties that determine the overall cost of ocean liming (OL) such as the CO2 uptake efficiency per unit of material, distribution strategies avoiding carbonate precipitation which would compromise efficiency, and technology availability (e.g., solar calciners). We find that at economic costs of 130–295 $/tCO2 net-removed, ocean liming could be a competitive CDR option which could make a significant contribution towards the Paris climate target. As the techno-economic assessment identified no showstoppers, we argue for more research on ecosystem impacts, governance, monitoring, reporting, and verification, and technology development and assessment to determine whether ocean liming and other OAE should be considered as part of a broader CDR portfolio. KW - carbon dioxide removal (CDR) KW - ocean alkalinity enhancement (OAE) KW - ocean liming (OL) KW - echno-economic assessment KW - uptake efficiency Y1 - 2024 U6 - https://doi.org/10.1088/1748-9326/ad5192 SN - 1748-9326 VL - 19 IS - 7 PB - IOP Publishing CY - Bristol ER - TY - JOUR A1 - Weinhold, Beate ED - Denz, Rebekka ED - Rudolf, Gabi T1 - Hilfe für Erez Israel BT - Spendenbelege in fränkischen Genisot: Eine Bestandsaufnahme JF - Genisa Blätter III KW - Franken KW - Jüdische Studien KW - Landesgeschichte KW - Ländliches Judentum KW - Franconia KW - Geniza KW - Jewish Studies KW - Rural Jewry KW - regional history KW - Genisa Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-470975 SN - 978-3-86956-470-8 SP - 99 EP - 121 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - EL Mahmoud, Khaled T1 - Measuring with double legal standards BT - Germany’s intervention in support of Israel before the ICJ T2 - Verfassungsblog : on matters constitutional Y1 - 2024 UR - https://verfassungsblog.de/measuring-with-double-legal-standards-germanys-intervention-in-support-of-israel-before-the-icj/ U6 - https://doi.org/10.59704/1c5ec794a420161f SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - GEN A1 - Bilgen, Isa T1 - Freiheit und Nachhaltigkeit im Verfassungswandel T2 - Verfassungsblog : on matters constitutional N2 - Mit dem Klima wandelt sich auch notwendig die offene Gesellschaft. Und mit ihr wandelt sich wiederum auch die Verfassung(-sinterpretation). Periodisch wiederkehrende Gesundheits- und Sicherheitskrisen fordern eine dynamische Reaktion des Grundgesetzes auf mit ihnen einhergehende Probleme. In andauernden Krisen wie der Umweltkrise muss die Verfassung gleichzeitig in vielerlei Hinsicht nachhaltig sein. Dabei muss das, was wir unter Freiheit, Klima‑, Umwelt- oder Tierschutz verstehen, immer im Wandel bleiben. Y1 - 2023 UR - https://verfassungsblog.de/freiheit-und-nachhaltigkeit-im-verfassungswandel/ U6 - https://doi.org/10.17176/20230617-231023-0 SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - GEN A1 - Weigl, Hannes T1 - Opfer der Diplomatie BT - von moderner Sklaverei, ausgehebelter Immunität und der schwierigen Suche nach Gerechtigkeit T2 - Verfassungsblog : on matters constitutional Y1 - 2022 UR - https://verfassungsblog.de/opfer-der-diplomatie/ U6 - https://doi.org/10.17176/20221208-001620-0 SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - GEN A1 - Köhne, Lea T1 - (State) immunity for Palestine? T2 - Verfassungsblog : on matters constitutional Y1 - 2023 UR - https://verfassungsblog.de/state-immunity-for-palestine/ U6 - https://doi.org/10.59704/c6b1bf054163ad38 SN - 2366-7044 PB - Max Steinbeis Verfassungsblog gGmbH CY - Berlin ER - TY - JOUR A1 - Wardelmann, Kristina A1 - Rath, Michaela A1 - Castro, José Pedro A1 - Blümel, Sabine A1 - Schell, Mareike A1 - Hauffe, Robert A1 - Schumacher, Fabian A1 - Flore, Tanina A1 - Ritter, Katrin A1 - Wernitz, Andreas A1 - Hosoi, Toru A1 - Ozawa, Koichiro A1 - Kleuser, Burkhard A1 - Weiß, Jürgen A1 - Schürmann, Annette A1 - Kleinridders, André T1 - Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism and insulin sensitivity in the hypothalamus JF - Antioxidants N2 - Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. Although insulin activates this response and improves metabolism, the metabolic impact of one of its members, the mitochondrial chaperone heat shock protein 10 (Hsp10), is unknown. Thus, we hypothesized that a reduction of Hsp10 in hypothalamic neurons will impair mitochondrial function and impact brain insulin action. Therefore, we investigated the role of chaperone Hsp10 by introducing a lentiviral-mediated Hsp10 knockdown (KD) in the hypothalamic cell line CLU-183 and in the arcuate nucleus (ARC) of C57BL/6N male mice. We analyzed mitochondrial function and insulin signaling utilizing qPCR, Western blot, XF96 Analyzer, immunohistochemistry, and microscopy techniques. We show that Hsp10 expression is reduced in T2D mice brains and regulated by leptin in vitro. Hsp10 KD in hypothalamic cells induced mitochondrial dysfunction with altered fatty acid metabolism and increased mitochondria-specific oxidative stress resulting in neuronal insulin resistance. Consequently, the reduction of Hsp10 in the ARC of C57BL/6N mice caused hypothalamic insulin resistance with acute liver insulin resistance. KW - brain insulin signaling KW - mitochondria KW - oxidative stress KW - fatty acid metabolism Y1 - 2021 U6 - https://doi.org/10.3390/antiox10050711 SN - 2076-3921 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Heide, Judith A1 - Netzebandt, Jonka A1 - Ahrens, Stine A1 - Brüsch, Julia A1 - Saalfrank, Teresa A1 - Schmitz-Antonischki, Dorit T1 - Improving lexical retrieval with LingoTalk BT - an app-based, self-administered treatment for clients with aphasia JF - Frontiers in communication N2 - Introduction LingoTalk is a German speech-language app designed to enhance lexical retrieval in individuals with aphasia. It incorporates automatic speech recognition (ASR) to provide therapist-independent feedback. The execution and effectiveness of a self-administered intervention with LingoTalk was explored in a case series study. Methods Three individuals with chronic aphasia participated in a highly individualized, supervised self-administered intervention lasting 3 weeks. The LingoTalk app closely monitored the frequency, intensity and progress of the intervention. Treatment efficacy was assessed using a multiple baseline design, examining both item-specific treatment effects and generalization to untreated items, an untreated task, and spontaneous speech. Results All participants successfully completed the intervention with LingoTalk, although one participant was not able to use the ASR feature. None of the participants fully adhered to the treatment protocol. All participants demonstrated significant and sustained improvement in the naming of practiced items, although there was limited evidence of generalization. Additionally, there was a slight reduction in word-finding difficulties during spontaneous speech. Discussion This small-scale study indicates that self-administered intervention with LingoTalk can improve oral naming of treated items. Thus, it has the potential to complement face-to-face speech-language therapy, such as within in a “flipped speech room” approach. The choice of feedback mode is discussed. Transparent progress monitoring of the intervention appears to positively influence patients' motivation. KW - aphasi KW - anomia KW - lexical retrieva KW - oral naming KW - app-based intervention KW - self-training KW - automatic speech recognition (ASR) KW - LingoTalk Y1 - 2023 U6 - https://doi.org/10.3389/fcomm.2023.1210193 SN - 2297-900X VL - 8 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Uth, Melanie A1 - Gutiérrez-Bravo, Rodrigo A1 - Fliessbach, Jan T1 - On the incompatibility of object fronting and progressive aspect in Yucatec Maya JF - Frontiers in language sciences N2 - In this paper, we present data from an elicitation study and a corpus study that support the observation that the Yucatec Maya progressive aspect auxiliary táan is replaced by the habitual auxiliary k in sentences with contrastively focused fronted objects. Focus has been extensively studied in Yucatec, yet the incompatibility of object fronting and progressive aspect in Yucatec Maya remains understudied. Both our experimental results and our corpus study point in the direction that this incompatibility may very well be categorical. Theoretically, we take a progressive reading to be derived from an imperfectivity operator in combination with a singular operator, and we propose that this singular operator implicates the negation of event plurality, leading to an exhaustive interpretation which ranks below corrective focus on a contrastive focus scale. This means that, in a sentence with object focus fronting, the use of the marked auxiliary táan (as opposed to the more general k) would trigger two contrastive foci, which would be an unlikely and probably dispreferred speech act. KW - fronting KW - progressive KW - Yucatec Maya KW - habitual KW - focus Y1 - 2024 U6 - https://doi.org/10.3389/flang.2023.1286520 SN - 2813-4605 VL - 2 PB - Frontiers Media S.A. CY - Lausanne, Switzerland ER - TY - JOUR A1 - Blaser, Berenike Lisa A1 - Weymar, Mathias A1 - Wendt, Julia T1 - The effect of a single-session heart rate variability biofeedback on attentional control BT - does stress matter? JF - Frontiers in psychology N2 - Introduction Vagally mediated heart rate variability is an index of autonomic nervous system activity that is associated with a large variety of outcome variables including psychopathology and self-regulation. While practicing heart rate variability biofeedback over several weeks has been reliably associated with a number of positive outcomes, its acute effects are not well known. As the strongest association with vagally mediated heart rate variability has been found particularly within the attention-related subdomain of self-regulation, we investigated the acute effect of heart rate variability biofeedback on attentional control using the revised Attention Network Test. Methods Fifty-six participants were tested in two sessions. In one session each participant received a heart rate variability biofeedback intervention, and in the other session a control intervention of paced breathing at a normal ventilation rate. After the biofeedback or control intervention, participants completed the Attention Network Test using the Orienting Score as a measure of attentional control. Results Mixed models revealed that higher resting baseline vagally mediated heart rate variability was associated with better performance in attentional control, which suggests more efficient direction of attention to target stimuli. There was no significant main effect of the intervention on attentional control. However, an interaction effect indicated better performance in attentional control after biofeedback in individuals who reported higher current stress levels. Discussion The results point to acute beneficial effects of heart rate variability biofeedback on cognitive performance in highly stressed individuals. Although promising, the results need to be replicated in larger or more targeted samples in order to reach stronger conclusions about the effects. KW - attention KW - self-regulation KW - heart rate variability KW - biofeedback KW - cognitive control KW - stress KW - vagal tone KW - slow-paced breathing Y1 - 2023 U6 - https://doi.org/10.3389/fpsyg.2023.1292983 SN - 1664-1078 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Bürger, Gerd A1 - Heistermann, Maik T1 - Shallow and deep learning of extreme rainfall events from convective atmospheres JF - Natural hazards and earth system sciences : NHESS N2 - Our subject is a new catalogue of radar-based heavy rainfall events (CatRaRE) over Germany and how it relates to the concurrent atmospheric circulation. We classify daily ERA5 fields of convective indices according to CatRaRE, using an array of 13 statistical methods, consisting of 4 conventional (“shallow”) and 9 more recent deep machine learning (DL) algorithms; the classifiers are then applied to corresponding fields of simulated present and future atmospheres from the Coordinated Regional Climate Downscaling Experiment (CORDEX) project. The inherent uncertainty of the DL results from the stochastic nature of their optimization is addressed by employing an ensemble approach using 20 runs for each network. The shallow random forest method performs best with an equitable threat score (ETS) around 0.52, followed by the DL networks ALL-CNN and ResNet with an ETS near 0.48. Their success can be understood as a result of conceptual simplicity and parametric parsimony, which obviously best fits the relatively simple classification task. It is found that, on summer days, CatRaRE convective atmospheres over Germany occur with a probability of about 0.5. This probability is projected to increase, regardless of method, both in ERA5-reanalyzed and CORDEX-simulated atmospheres: for the historical period we find a centennial increase of about 0.2 and for the future period one of slightly below 0.1. Y1 - 2023 U6 - https://doi.org/10.5194/nhess-23-3065-2023 SN - 1684-9981 VL - 23 IS - 9 SP - 3065 EP - 3077 PB - European Geophysical Society CY - Katlenburg-Lindau ER - TY - JOUR A1 - Schell, Mareike A1 - Wardelmann, Kristina A1 - Hauffe, Robert A1 - Rath, Michaela A1 - Chopra, Simran A1 - Kleinridders, André T1 - Lactobacillus rhamnosus sex-specifically attenuates depressive-like behavior and mitigates metabolic consequences in obesity JF - Biological psychiatry: global open science N2 - BACKGROUND: Patients with diabetes exhibit an increased prevalence for emotional disorders compared with healthy humans, partially due to a shared pathogenesis including hormone resistance and inflammation, which is also linked to intestinal dysbiosis. The preventive intake of probiotic lactobacilli has been shown to improve dysbiosis along with mood and metabolism. Yet, a potential role of Lactobacillus rhamnosus (Lacticaseibacillus rhamnosus 0030) (LR) in improving emotional behavior in established obesity and the underlying mechanisms are unknown. METHODS: Female and male C57BL/6N mice were fed a low-fat diet (10% kcal from fat) or high-fat diet (HFD) (45% kcal from fat) for 6 weeks, followed by daily oral gavage of vehicle or 1 3 10 8 colony-forming units of LR, and assessment of anxiety- and depressive-like behavior. Cecal microbiota composition was analyzed using 16S ribosomal RNA sequencing, plasma and cerebrospinal fluid were collected for metabolomic analysis, and gene expression of different brain areas was assessed using reverse transcriptase quantitative polymerase chain reaction. RESULTS: We observed that 12 weeks of HFD feeding induced hyperinsulinemia, which was attenuated by LR application only in female mice. On the contrary, HFD-fed male mice exhibited increased anxiety- and depressive-like behavior, where the latter was specifically attenuated by LR application, which was independent of metabolic changes. Furthermore, LR application restored the HFD-induced decrease of tyrosine hydroxylase, along with normalizing cholecystokinin gene expression in dopaminergic brain regions; both tyrosine hydroxylase and cholecystokinin are involved in signaling pathways impacting emotional disorders. CONCLUSIONS: Our data show that LR attenuates depressive-like behavior after established obesity, with changes in the dopaminergic system in male mice, and mitigates hyperinsulinemia in obese female mice. Y1 - 2023 U6 - https://doi.org/10.1016/j.bpsgos.2023.02.011 SN - 2667-1743 VL - 3 IS - 4 SP - 651 EP - 662 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ziubanova, Anastasia A. A1 - Laurinavichyute, Anna A1 - Parshina, Olga T1 - Does early exposure to spoken and sign language affect reading fluency in deaf and hard-of-hearing adult signers? JF - Frontiers in psychology N2 - Introduction Early linguistic background, and in particular, access to language, lays the foundation of future reading skills in deaf and hard-of-hearing signers. The current study aims to estimate the impact of two factors – early access to sign and/or spoken language – on reading fluency in deaf and hard-of-hearing adult Russian Sign Language speakers. Methods In the eye-tracking experiment, 26 deaf and 14 hard-of-hearing native Russian Sign Language speakers read 144 sentences from the Russian Sentence Corpus. Analysis of global eye-movement trajectories (scanpaths) was used to identify clusters of typical reading trajectories. The role of early access to sign and spoken language as well as vocabulary size as predictors of the more fluent reading pattern was tested. Results Hard-of-hearing signers with early access to sign language read more fluently than those who were exposed to sign language later in life or deaf signers without access to speech sounds. No association between early access to spoken language and reading fluency was found. Discussion Our results suggest a unique advantage for the hard-of-hearing individuals from having early access to both sign and spoken language and support the existing claims that early exposure to sign language is beneficial not only for deaf but also for hard-of-hearing children. KW - reading fluency KW - deaf KW - hard-of-hearing KW - sign language KW - multimodal bilingualism KW - scanpaths KW - eye movements Y1 - 2023 U6 - https://doi.org/10.3389/fpsyg.2023.1145638 SN - 1664-1078 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Rosenblum, Michael A1 - Pikovsky, Arkady T1 - Inferring connectivity of an oscillatory network via the phase dynamics reconstruction JF - Frontiers in network physiology N2 - We review an approach for reconstructing oscillatory networks’ undirected and directed connectivity from data. The technique relies on inferring the phase dynamics model. The central assumption is that we observe the outputs of all network nodes. We distinguish between two cases. In the first one, the observed signals represent smooth oscillations, while in the second one, the data are pulse-like and can be viewed as point processes. For the first case, we discuss estimating the true phase from a scalar signal, exploiting the protophase-to-phase transformation. With the phases at hand, pairwise and triplet synchronization indices can characterize the undirected connectivity. Next, we demonstrate how to infer the general form of the coupling functions for two or three oscillators and how to use these functions to quantify the directional links. We proceed with a different treatment of networks with more than three nodes. We discuss the difference between the structural and effective phase connectivity that emerges due to high-order terms in the coupling functions. For the second case of point-process data, we use the instants of spikes to infer the phase dynamics model in the Winfree form directly. This way, we obtain the network’s coupling matrix in the first approximation in the coupling strength. KW - oscillations KW - network KW - connectivity KW - data analysis KW - phase reduction Y1 - 2023 U6 - https://doi.org/10.3389/fnetp.2023.1298228 SN - 2674-0109 VL - 3 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Sammoud, Senda A1 - Bouguezzi, Raja A1 - Uthoff, Aaron A1 - Ramirez-Campillo, Rodrigo A1 - Moran, Jason A1 - Negra, Yassine A1 - Hachana, Younes A1 - Chaabene, Helmi T1 - The effects of backward vs. forward running training on measures of physical fitness in young female handball players JF - Frontiers in sports and active living N2 - Introduction This study examined the effects of an 8-week backward running (BR) vs. forward running (FR) training programmes on measures of physical fitness in young female handball players. Methods Twenty-nine players participated in this study. Participants were randomly assigned to a FR training group, BR training group, and a control group. Results and discussion Within-group analysis indicated significant, small-to-large improvements in all performance tests (effect size [g] = 0.36 to 1.80), except 5-m forward sprint-time in the BR group and 5- and 10-m forward sprint-time in the FR group. However, the CG significantly decreased forward sprint performance over 10-m and 20-m (g = 0.28 to 0.50) with no changes in the other fitness parameters. No significant differences in the amount of change scores between the BR and FR groups were noted. Both training interventions have led to similar improvements in measures of muscle power, change of direction (CoD) speed, sprint speed either forward or backward, and repeated sprint ability (RSA) in young female handball players, though BR training may have a small advantage over FR training for 10-m forward sprint time and CoD speed, while FR training may provide small improvements over BR training for RSAbest. Practitioners are advised to consider either FR or BR training to improve various measures of physical fitness in young female handball players. KW - team sports KW - athletic performance KW - motor activity KW - youth sports KW - sports medicine Y1 - 2023 U6 - https://doi.org/10.3389/fspor.2023.1244369 SN - 2624-9367 VL - 5 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Blasimann, Angela A1 - Busch, Aglaja A1 - Henle, Philipp A1 - Bruhn, Sven A1 - Vissers, Dirk A1 - Baur, Heiner T1 - Neuromuscular control during stair descent and artificial tibial translation after acute ACL rupture JF - Orthopaedic journal of sports medicine N2 - Background: Anterior cruciate ligament (ACL) rupture has direct effect on passive and active knee stability and, specifically, stretch-reflex excitability. Purpose/Hypothesis: The purpose of this study was to investigate neuromuscular activity in patients with an acute ACL deficit (ACL-D group) compared with a matched control group with an intact ACL (ACL-I group) during stair descent and artificially induced anterior tibial translation. It was hypothesized that neuromuscular control would be impaired in the ACL-D group. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Surface electromyographic (EMG) activity of the vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), and semitendinosus (ST) muscles was recorded bilaterally in 15 patients with ACL-D (mean, 13.8 days [range, 7-21 days] since injury) and 15 controls with ACL-I during stair descent and artificially induced anterior tibial translation. The movements of stair descent were divided into preactivity, weight acceptance, and push-off phases. Reflex activity during anterior tibial translation was split into preactivity and short, medium, and late latency responses. Walking on a treadmill was used for submaximal EMG normalization. Kruskal-Wallis test and post hoc analyses with Dunn-Bonferroni correction were used to compare normalized root mean square values for each muscle, limb, movement, and reflex phase between the ACL-D and ACL-I groups. Results: During the preactivity phase of stair descent, the hamstrings of the involved leg of the ACL-D group showed 33% to 51% less activity compared with the matched leg and contralateral leg of the ACL-I group (P <.05). During the weight acceptance and push-off phases, the VL revealed a significant reduction (approximately 40%) in the involved leg of the ACL-D group compared with the ACL-I group. At short latency, the BF and ST of the involved leg of the ACL-D group showed a significant increase in EMG activity compared with the uninvolved leg of the ACL-I group, by a factor of 2.2 to 4.6. Conclusion: In the acute phase after an ACL rupture, neuromuscular alterations were found mainly in the hamstrings of both limbs during stair descent and reflex activity. The potential role of prehabilitation needs to be further studied. KW - acute KW - anterior cruciate ligament KW - neuromuscular control KW - rupture KW - stairs KW - tibial translation Y1 - 2022 U6 - https://doi.org/10.1177/23259671221123299 SN - 2325-9671 VL - 10 IS - 10 PB - Sage ER - TY - JOUR A1 - Hauffe, Robert A1 - Rath, Michaela A1 - Schell, Mareike A1 - Ritter, Katrin A1 - Kappert, Kai A1 - Deubel, Stefanie A1 - Ott, Christiane A1 - Jähnert, Markus A1 - Jonas, Wenke A1 - Schürmann, Annette A1 - Kleinridders, André T1 - HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue JF - Molecular Metabolism N2 - Objective Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. The aim of this investigation was to determine the effect of a reduced HSP60 expression on the development of obesity and insulin resistance. Methods Control and heterozygous whole-body HSP60 knockout (Hsp60+/−) mice were fed a high-fat diet (HFD, 60% calories from fat) for 16 weeks and subjected to extensive metabolic phenotyping. To understand the effect of HSP60 on white adipose tissue, microarray analysis of gonadal WAT was performed, ex vivo experiments were performed, and a lentiviral knockdown of HSP60 in 3T3-L1 cells was conducted to gain detailed insights into the effect of reduced HSP60 levels on adipocyte homeostasis. Results Male Hsp60+/− mice exhibited lower body weight with lower fat mass. These mice exhibited improved insulin sensitivity compared to control, as assessed by Matsuda Index and HOMA-IR. Accordingly, insulin levels were significantly reduced in Hsp60+/− mice in a glucose tolerance test. However, Hsp60+/− mice exhibited an altered adipose tissue metabolism with elevated insulin-independent glucose uptake, adipocyte hyperplasia in the presence of mitochondrial dysfunction, altered autophagy, and local insulin resistance. Conclusions We discovered that the reduction of HSP60 in mice predominantly affects adipose tissue homeostasis, leading to beneficial alterations in body weight, body composition, and adipocyte morphology, albeit exhibiting local insulin resistance. KW - Mitochondria KW - Stress response KW - Obesity KW - Glucose homeostasis KW - Insulin resistance KW - Adipose tissue Y1 - 2021 U6 - https://doi.org/10.1016/j.molmet.2021.101276 SN - 2212-8778 VL - 53 SP - 1 EP - 14 PB - Elsevier CY - Amsterdam, Niederlande ER - TY - JOUR A1 - Hauffe, Robert A1 - Rath, Michaela A1 - Agyapong, Wilson A1 - Jonas, Wenke A1 - Vogel, Heike A1 - Schulz, Tim Julius A1 - Schwarz, Maria A1 - Kipp, Anna Patricia A1 - Blüher, Matthias A1 - Kleinridders, André T1 - Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling JF - Antioxidants N2 - The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo. KW - selenite KW - insulin KW - adipose tissue KW - obesity KW - insulin resistance Y1 - 2022 U6 - https://doi.org/10.3390/antiox11050862 SN - 2076-3921 VL - 11 SP - 1 EP - 16 PB - MDPI CY - Basel, Schweiz ET - 5 ER - TY - THES A1 - Ritt, Vanessa T1 - Unbemannte Schiffe im Internationalen Seerecht T2 - Acta Iuridica Universitatis Potsdamiensis N2 - Die internationale Schifffahrt erhofft sich mit der Entwicklung unbemannter Schiffe, die nur noch von Kontrollzentren an Land durch Personal überwacht werden und sonst durch Elektromotoren und Solarenergie betrieben und mit selbstlernenden Navigationsprogrammen ausgestattet weitgehend autark agieren, eine Einsparung von Transportkosten von über 20 %. Diese voranschreitende technische Entwicklung wird insbesondere das internationale Seerecht in Zukunft vor Herausforderungen stellen. Das Werk untersucht vor diesem Hintergrund primär die Kompatibilität dieser Schiffe mit dem Seerechtsübereinkommen. Zunächst wird eine Schiffsdefinition für den Vertrag entwickelt und eine Anwendung des Regelwerks auf autonome Schiffe überprüft. Dann wird auf Problemfelder wie die Einhaltung von Pflichten durch die Schiffe, die Notwendigkeit besonderer Schutzrechte vor allem in Bezug auf Zwangsmaßnahmen durch die Küstenstaaten an Bord und die Anwendbarkeit der bestehenden Piraterievorschriften auf diese Schiffe eingegangen. Weiter wirft die Arbeit die Frage auf, ob die Staatengemeinschaft, besonders mit Hinblick auf den maritimen Umweltschutz, nach dem Seerechtsübereinkommen eine Pflicht zur Förderung unbemannter Schiffe hat. Abschließend wird auf erforderliche Cyber Security Maßnahmen für diesen besonderen Schiffstyp eingegangen. Insgesamt zeigt sich nach dieser Analyse, dass das Seerechtsübereinkommen, mit überschaubaren Anpassungen, gut Anwendung auf autonome Schiffe finden kann. N2 - With the development of unmanned ships, which are only monitored by personnel from control centers on land and otherwise operated by electric motors, solar energy and equipped with self-learning navigation programs, international shipping hopes that transport costs will be reduced by more than 20%. This advancing technical development will present international maritime law with challenges in the future. Against this background, the thesis primarily examines the compatibility of these ships with the United Nations Convention on the Law of the Sea. First the author develops a definition for the term ship and evaluates the application of the contract to autonomous ships. Then problem areas such as compliance with contractual obligations, the need for special protective rights for the flag states, especially with regard to coercive measures by the coastal states on board, and the applicability of the existing piracy regulations to these ships are discussed. The thesis also raises the question whether the international community, especially with regard to maritime environmental protection, has an obligation to promote unmanned ships under the United Nations Convention on the Law of the Sea. Finally, the necessary cyber security measures for this particular type of ship are evaluated. In conclusion, the analysis shows that the Convention on the Law of the Sea, with minor adjustments, can be applied to unmanned vessels. T2 - Unmanned vessels and the International Law of the Sea T3 - Acta Iuridica Universitatis Potsdamiensis - 8 KW - Seerecht KW - unbemannte Schiffe KW - internationales Seerecht KW - maritimer Umweltschutz KW - Piraterie KW - Seerechtsübereinkommen KW - piracy KW - law of the sea KW - United Nations Convention on the Law of the Sea KW - international law of the sea KW - maritime environmental protection KW - unmanned vessel KW - unmanned ship Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-519385 SN - 978-3-86956-522-4 SN - 2199-9686 SN - 2199-9694 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - THES A1 - Ganschow, Constantin Alexander T1 - Die Konversion im Asylverfahren T2 - Acta Iuridica Universitatis Potsdamiensis N2 - Der Verfasser beschäftigt sich mit der Frage des Glaubensübertritts in einem Asylverfahren. Dabei nimmt er Zeitpunkt, Art und Umstände des Religionswechsels in den Blick. Ferner untersucht er, wie die sogenannte Konversion von den zuständigen Behörden und Gerichten zu behandeln und zu bewerten ist. Einführend gibt er einen Überblick zum völkerrechtlichen Schutz der Religions- und Weltanschauungsfreiheit sowie typischen Gefährdungslagen. Überdies befasst er sich mit den Rechtsgrundlagen des Asyl- und Flüchtlingsschutzrechts und stellt Verbindungen zum Flucht- und Verfolgungsgrund der Religion her. Schwerpunkt bildet die Untersuchung der Verfahrensstadien, in denen die Konversion relevant wird. Dabei berücksichtigt der Verfasser die nationale und europäische Rechtsprechung. Von besonderer Bedeutung sind die Ausführungen zum Zusammenspiel von staatlichen Ermittlungspflichten und Mitwirkungsgeboten von Asylantragstellenden, wobei den Besonderheiten des grund- und menschenrechtlichen Mehrebenensystems Rechnung getragen wird. Zentral sind ferner die Ausführungen zum Umgang mit Taufurkunden und sonstigen Bescheinigungen über die religiöse Überzeugung. Besonderes Gewicht liegt auf der verfassungsrechtlichen Stellung der Religionsgemeinschaften und der Frage, ob die Entscheidung einer Religionsgemeinschaft, ein neues Mitglied aufzunehmen, die Behörde im Asylverfahren bindet. Diesem Problem widmet sich der Verfasser unter Heranziehung der relevanten Literaturstimmen und einschlägigen Rechtsprechung. Der rechtswissenschaftliche Beitrag bietet den beteiligten Akteuren nicht nur eine Einführung in das Themengebiet des Glaubensübertritts im Asylverfahren, sondern gibt den Lesenden auch eine praxistaugliche Handlungsunterstützung rund um die wichtigsten Fragen einer Konversion im Asylverfahren an die Hand. Praktische Bezüge entstehen beispielsweise dadurch, dass wichtige Impulse und Empfehlungen für eine gleichermaßen moderne, rechtsstaatliche und grundrechtsorientierte Verfahrensführung entwickelt werden. N2 - This thesis addresses questions related to the conversion of faith during an asylum procedure. It explores how these conversions of faith are treated and assessed by the relevant authorities and courts, whereby the timing, nature and circumstances of the conversion is taken into account. The thesis begins with an overview of the fundamental human right of freedom of religion and belief and typical risks associated to this. In addition, the legal basis of asylum and refugee protection law is discussed and linked to religion as a reason for flight and persecution. Next, procedural stages which are affected by a conversion of faith are analysed in-depth. Here national and European case law is taken into account. Of particular importance is the interplay of the state's duty to inquire and the co-operation requirements of the asylum seeker, whereby special attention is placed on the multi-level governance of fundamental human rights. The handeling of baptismal certificates and other certificates of religious conviction is another important consideration. Particular emphasis is placed on the constitutional standing of the religious communities and the question of whether the decision of a religious community to accept a new member binds the authority in the asylum procedure. This problem is analysed with reference to current literature and relevant rulings. The jurisprudential thesis not only offers the reader an introduction to the topic of faith conversion during in the asylum procedure, but also practice oriented support around the most pressing questions of dealing with these conversions during an asylum procedure. Specific recommendations and impulses are presented to develop an equally modern, constitutional and fundamental rights-oriented procedural management. T3 - Acta Iuridica Universitatis Potsdamiensis - 7 KW - Anhörung KW - Asyl KW - Asylantrag KW - Asylgesetz KW - Asylrecht KW - Asylverfahren KW - Begleitung KW - Bescheinigung KW - Beweismittel KW - Ehrenamtliche KW - Ermittlungspflicht KW - Flucht KW - Flüchtling KW - Flüchtlingsschutz KW - Folgeantrag KW - Gemeinde KW - Glauben KW - Glaubensfreiheit KW - Glaubensprüfung KW - Glaubenswechsel KW - Mitwirkungspflicht KW - Nachfluchtgrund KW - Religiöse Verfolgung KW - Religion KW - Religionsfreiheit KW - Religionsgemeinschaft KW - Religions- und Weltanschauungsfreiheit KW - Religionswechsel KW - Sachverhaltsaufklärung KW - Sachverhaltsaufklärungspflicht KW - Selbstbestimmungsrecht KW - Selbstbestimmungsrecht der Religionsgemeinschaften KW - Sonderbeauftragte KW - Sonderbeauftragte für religiöse Verfolgung KW - Taufurkunde KW - Glaubensübertritt KW - Kirche KW - Konversion KW - Verfolgung KW - Verfolgungsgrund KW - asylum KW - asylum procedure KW - baptismal certificate KW - certificate of religious conviction KW - conversion KW - faith KW - flight KW - freedom of religion and belief KW - non-refoulement KW - post-flight activities KW - refugee KW - refugee law KW - refugee protection KW - religion KW - risk KW - persecution KW - protection Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-505819 SN - 978-3-86956-509-5 SN - 2199-9686 SN - 2199-9694 IS - 7 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Zhou, Lin A1 - Fischer, Eric A1 - Brahms, Clemens Markus A1 - Granacher, Urs A1 - Arnrich, Bert T1 - DUO-GAIT BT - a gait dataset for walking under dual-task and fatigue conditions with inertial measurement units JF - Scientific data N2 - In recent years, there has been a growing interest in developing and evaluating gait analysis algorithms based on inertial measurement unit (IMU) data, which has important implications, including sports, assessment of diseases, and rehabilitation. Multi-tasking and physical fatigue are two relevant aspects of daily life gait monitoring, but there is a lack of publicly available datasets to support the development and testing of methods using a mobile IMU setup. We present a dataset consisting of 6-minute walks under single- (only walking) and dual-task (walking while performing a cognitive task) conditions in unfatigued and fatigued states from sixteen healthy adults. Especially, nine IMUs were placed on the head, chest, lower back, wrists, legs, and feet to record under each of the above-mentioned conditions. The dataset also includes a rich set of spatio-temporal gait parameters that capture the aspects of pace, symmetry, and variability, as well as additional study-related information to support further analysis. This dataset can serve as a foundation for future research on gait monitoring in free-living environments. Y1 - 2023 U6 - https://doi.org/10.1038/s41597-023-02391-w SN - 2052-4463 VL - 10 IS - 1 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Witzel, Katja A1 - Abu Risha, Marua A1 - Albers, Philip A1 - Börnke, Frederik A1 - Hanschen, Franziska S. T1 - Identification and Characterization of Three Epithiospecifier Protein Isoforms in Brassica oleracea JF - Frontiers in plant science N2 - Glucosinolates present in Brassicaceae play a major role in herbivory defense. Upon tissue disruption, glucosinolates come into contact with myrosinase, which initiates their breakdown to biologically active compounds. Among these, the formation of epithionitriles is triggered by the presence of epithiospecifier protein (ESP) and a terminal double bond in the glucosinolate side chain. One ESP gene is characterized in the model plant Arabidopsis thaliana (AtESP; At1g54040.2). However, Brassica species underwent genome triplication since their divergence from the Arabidopsis lineage. This indicates the presence of multiple ESP isoforms in Brassica crops that are currently poorly characterized. We identified three B. oleracea ESPs, specifically BoESP1 (LOC106296341), BoESP2 (LOC106306810), and BoESP3 (LOC106325105) based on in silico genome analysis. Transcript and protein abundance were assessed in shoots and roots of four B. oleracea vegetables, namely broccoli, kohlrabi, white, and red cabbage, because these genotypes showed a differential pattern for the formation of glucosinolate hydrolysis products as well for their ESP activity. BoESP1 and BoESP2 were expressed mainly in shoots, while BoESP3 was abundant in roots. Biochemical characterization of heterologous expressed BoESP isoforms revealed different substrate specificities towards seven glucosinolates: all isoforms showed epithiospecifier activity on alkenyl glucosinolates, but not on non-alkenyl glucosinolates. The pH-value differently affected BoESP activity: while BoESP1 and BoESP2 activities were optimal at pH 6-7, BoESP3 activity remained relatively stable from pH 4 to 7. In order test their potential for the in vivo modification of glucosinolate breakdown, the three isoforms were expressed in A. thaliana Hi-0, which lacks AtESP expression, and analyzed for the effect on their respective hydrolysis products. The BoESPs altered the hydrolysis of allyl glucosinolate in the A. thaliana transformants to release 1-cyano-2,3-epithiopropane and reduced formation of the corresponding 3-butenenitrile and allyl isothiocyanate. Plants expressing BoESP2 showed the highest percentage of released epithionitriles. Given these results, we propose a model for isoform-specific roles of B. oleracea ESPs in glucosinolate breakdown. KW - epithionitrile KW - expression profile KW - functional complementation KW - glucosinolate hydrolysis KW - nitrile KW - specifier proteins KW - tissue specificity Y1 - 2019 U6 - https://doi.org/10.3389/fpls.2019.01552 SN - 1664-462X VL - 10 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Grum, Marcus A1 - Hiessl, Werner A1 - Maresch, Karl A1 - Gronau, Norbert T1 - Design of a neuronal training modeling language BT - exemplified with the AI-based dynamic GUI adaption JF - AIS-Transactions on enterprise systems N2 - As the complexity of learning task requirements, computer infrastruc- tures and knowledge acquisition for artificial neuronal networks (ANN) is in- creasing, it is challenging to talk about ANN without creating misunderstandings. An efficient, transparent and failure-free design of learning tasks by models is not supported by any tool at all. For this purpose, particular the consideration of data, information and knowledge on the base of an integration with knowledge- intensive business process models and a process-oriented knowledge manage- ment are attractive. With the aim of making the design of learning tasks express- ible by models, this paper proposes a graphical modeling language called Neu- ronal Training Modeling Language (NTML), which allows the repetitive use of learning designs. An example ANN project of AI-based dynamic GUI adaptation exemplifies its use as a first demonstration. KW - AI and business informatics KW - development of AI-based systems KW - AI-based decision support system KW - cooperative AI (human-in-the-loop) KW - process-oriented knowledge acquisition KW - modeling language Y1 - 2021 UR - https://www.aes-journal.com/index.php/ais-tes/article/view/20/18 U6 - https://doi.org/10.30844/aistes.v5i1.20 SN - 1867-7134 VL - 5 IS - 1 PB - GITO-Publ., Verl. für Industrielle Informationstechnik und Organisation CY - Berlin ER - TY - JOUR A1 - Licht, Alexis A1 - Kelson, Julia A1 - Bergel, Shelly J. A1 - Schauer, Andrew J. A1 - Petersen, Sierra Victoria A1 - Capirala, Ashika A1 - Huntington, Katharine W. A1 - Dupont-Nivet, Guillaume A1 - Win, Zaw A1 - Aung, Day Wa T1 - Dynamics of pedogenic carbonate growth in the tropical domain of Myanmar JF - Geochemistry, geophysics, geosystems N2 - Pedogenic carbonate is widespread at mid latitudes where warm and dry conditions favor soil carbonate growth from spring to fall. The mechanisms and timing of pedogenic carbonate formation are more ambiguous in the tropical domain, where long periods of soil water saturation and high soil respiration enhance calcite dissolution. This paper provides stable carbon, oxygen and clumped isotope values from Quaternary and Miocene pedogenic carbonates in the tropical domain of Myanmar, in areas characterized by warm (>18°C) winters and annual rainfall up to 1,700 mm. We show that carbonate growth in Myanmar is delayed to the driest and coldest months of the year by sustained monsoonal rainfall from mid spring to late fall. The range of isotopic variability in Quaternary pedogenic carbonates can be solely explained by temporal changes of carbonate growth within the dry season, from winter to early spring. We propose that high soil moisture year-round in the tropical domain narrows carbonate growth to the driest months and makes it particularly sensitive to the seasonal distribution of rainfall. This sensitivity is also enabled by high winter temperatures, allowing carbonate growth to occur outside the warmest months of the year. This high sensitivity is expected to be more prominent in the geological record during times with higher temperatures and greater expansion of the tropical realm. Clumped isotope temperatures, δ13C and δ18O values of tropical pedogenic carbonates are impacted by changes of both rainfall seasonality and surface temperatures; this sensitivity can potentially be used to track past tropical rainfall distribution. KW - clumped isotopes KW - pedogenic carbonate KW - monsoon Y1 - 2022 U6 - https://doi.org/10.1029/2021GC009929 SN - 1525-2027 VL - 23 IS - 7 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Bimbinov, Arseniy A. A1 - Stage, Diana T1 - Развитие медицинского уголовного права в Германии и России JF - Vserossijskij kriminologičeskij žurnal : RKZ = Russian journal of criminology : RJC N2 - Negative consequences of the actions of medical professionals have always been subject to controversial assessment from the legal standpoint. There were periods in Russian history when doctors were prosecuted even without establishing their guilt first, and the periods when doctors were not held responsible at all for the violations that they committed. Currently, medical and pharmaceutical work is a complicated process of performing professional functions connected with the observance of established standards and requirements of its organization. Most medical tests and manipulations of prevention, research, diagnostic, treatment or rehabilitation character are regulated by formal protocols which could, in some cases, prevent a qualified doctor from saving a patient's life and in others - inflict forced harm on their health. Both of these situations require a legal assessment of the actions, the mechanism of which has not yet been fully determined. This circumstance could lead to a criminal prosecution of a medical professional whose fault is absent (or nonobvious). On the other hand, a structurally complex professional activity, for which there are no recognized methods of legal assessment, creates preconditions for various violations and abuses on the part of medical professionals. Changing relationships between a doctor and a patient, as well as the commercialization of modern medical practices have made the healthcare system one of the most delicto- and even criminally-oriented.
These factors act as causes for the growing complexity of legislation (in the wide sense of the word) on criminal liability of medical professionals and the controversial law enforcement practice which, in its turn, leads to the interest of researchers in these problems. The results of such research often remain unconnected with other achievements of the criminal law science; due to this, it is necessary to study the development of law, including the practice of law enforcement and the doctrine, on criminal liability of medical professionals - medical criminal law. Taking into consideration that such a sub-branch of law is not traditional for Russian science, the authors present the results of researching the development of medical criminal law not only in Russia, but also in Germany, where this sphere of law has long been established as independent. N2 - Неблагоприятные последствия, наступившие в процессе осуществления медицинской деятельности, с правовой точки зрения оценивались неоднозначно во все времена. В отечественной истории были периоды, когда лекарей казнили даже без установления их вины и когда докторов вообще не привлекали к ответственности за допущенные ими нарушения. В настоящее время медицинская и фармацевтическая деятельность представляет собой сложный процесс выполнения профессиональных функций, связанный с соблюдением установленных стандартов и требований к его организации. Большинство медицинских обследований и манипуляций, имеющих профилактическую, исследовательскую, диагностическую, лечебную или реабилитационную направленность, регламентировано формальными рамками протокола, который может в одной ситуации не позволить компетентному врачу спасти жизнь пациента, а в другой - причинить вынужденный вред его здоровью. Обе обозначенные ситуации потребуют правовой оценки содеянного, механизм которой до сих пор в полной мере не определен. Данное обстоятельство может повлечь привлечение медицинского работника к уголовной ответственности при отсутствии (или неочевидности) вины в его действиях. С другой стороны, структурно сложная профессиональная деятельность, не имеющая признанных методик правовой оценки, создает предпосылки для различного рода нарушений и злоупотреблений со стороны медицинских работников. Меняющиеся отношения между врачом и пациентом, а также коммерциализация современной медицинской практики привели к тому, что система здравоохранения сегодня является одной из самых деликто- и даже криминально ориентированных. Изложенное выступает причиной усложняющегося законодательства (в широком смысле слова) об уголовной ответственности медицинских работников и противоречивой правоприменительной практики, а это, в свою очередь, порождает научные исследования данных проблем. Результаты таких исследований часто существуют вне связи с другими достижениями уголовно-правовой науки, поэтому представляется необходимым изучить развитие права, включая правоприменение и доктрину, об уголовной ответственности медицинских работников - медицинское уголовное право. С учетом того что для отечественной науки выделение такой подотрасли права является нетрадиционным, в настоящей работе представлены результаты исследования развития медицинского уголовного права не только в России, но и в Германии, где уже давно сложилась и обособилась данная область права. T2 - The development of medical criminal law in Germany and in Russia KW - Iatrogeny KW - medical professionals KW - medical crimes KW - causing death KW - criminal liability KW - medical care KW - medical risk KW - ятрогения KW - медицинские работники KW - медицинские преступления KW - причинение смерти KW - уголовная ответственность KW - медицинская помощь KW - медицинский риск Y1 - 2021 UR - https://cj-bgu.ru/reader/article.aspx?id=24646 U6 - https://doi.org/10.17150/2500-4255.2021.15(4).456-465 SN - 2500-4255 SN - 2500-1442 VL - 15 IS - 4 SP - 456 EP - 465 PB - Bajkal'skij gosudarstvennij universitet CY - Irkutsk ER - TY - JOUR A1 - Wilhelmi, Ilka A1 - Neumann, Alexander A1 - Jähnert, Markus A1 - Ouni, Meriem A1 - Schürmann, Annette T1 - Enriched alternative splicing in islets of diabetes-susceptible mice JF - International journal of molecular sciences N2 - Dysfunctional islets of Langerhans are a hallmark of type 2 diabetes (T2D). We hypothesize that differences in islet gene expression alternative splicing which can contribute to altered protein function also participate in islet dysfunction. RNA sequencing (RNAseq) data from islets of obese diabetes-resistant and diabetes-susceptible mice were analyzed for alternative splicing and its putative genetic and epigenetic modulators. We focused on the expression levels of chromatin modifiers and SNPs in regulatory sequences. We identified alternative splicing events in islets of diabetes-susceptible mice amongst others in genes linked to insulin secretion, endocytosis or ubiquitin-mediated proteolysis pathways. The expression pattern of 54 histones and chromatin modifiers, which may modulate splicing, were markedly downregulated in islets of diabetic animals. Furthermore, diabetes-susceptible mice carry SNPs in RNA-binding protein motifs and in splice sites potentially responsible for alternative splicing events. They also exhibit a larger exon skipping rate, e.g., in the diabetes gene Abcc8, which might affect protein function. Expression of the neuronal splicing factor Srrm4 which mediates inclusion of microexons in mRNA transcripts was markedly lower in islets of diabetes-prone compared to diabetes-resistant mice, correlating with a preferential skipping of SRRM4 target exons. The repression of Srrm4 expression is presumably mediated via a higher expression of miR-326-3p and miR-3547-3p in islets of diabetic mice. Thus, our study suggests that an altered splicing pattern in islets of diabetes-susceptible mice may contribute to an elevated T2D risk. KW - alternative splicing KW - epigenetic KW - MicroRNA KW - RNAseq KW - diabetes KW - beta-cell KW - failure Y1 - 2021 U6 - https://doi.org/10.3390/ijms22168597 SN - 1422-0067 VL - 22 IS - 16 PB - Molecular Diversity Preservation International CY - Basel ER - TY - JOUR A1 - Gorin, Vladislav A. A1 - Scherz, Mark D. A1 - Korost, Dmitry V. A1 - Poyarkov, Nikolay A. T1 - Consequences of parallel miniaturisation in Microhylinae (Anura, Microhylidae), with the description of a new genus of diminutive South East Asian frogs JF - Zoosystematics and evolution : Mitteilungen aus dem Museum für Naturkunde in Berlin N2 - The genus Microhyla Tschudi, 1838 includes 52 species and is one of the most diverse genera of the family Microhylidae, being the most species-rich taxon of the Asian subfamily Microhylinae. The recent, rapid description of numerous new species of Microhyla with complex phylogenetic relationships has made the taxonomy of the group especially challenging. Several recent phylogenetic studies suggested paraphyly of Microhyla with respect to Glyphoglossus Gunther, 1869, and revealed three major phylogenetic lineages of mid-Eocene origin within this assemblage. However, comprehensive works assessing morphological variation among and within these lineages are absent. In the present study we investigate the generic taxonomy of Microhyla-Glyphoglossus assemblage based on a new phylogeny including 57 species, comparative morphological analysis of skeletons from cleared-and-stained specimens for 23 species, and detailed descriptions of generalized osteology based on volume-rendered micro-CT scans for five speciesal-together representing all major lineages within the group. The results confirm three highly divergent and well-supported clades that correspond with external and osteological morphological characteristics, as well as respective geographic distribution. Accordingly, acknowledging ancient divergence between these lineages and their significant morphological differentiation, we propose to consider these three lineages as distinct genera: Microhyla sensu stricto, Glyphoglossus, and a newly described genus, Nanohyla gen. nov. KW - Amphibians KW - integrative taxonomy KW - narrow-mouthed frogs KW - micro-computed tomography KW - Nanohyla gen. nov KW - osteology KW - sexual dimorphism KW - taxonomic revision Y1 - 2021 U6 - https://doi.org/10.3897/zse.97.57968 SN - 1860-0743 SN - 1435-1935 VL - 97 IS - 1 SP - 21 EP - 54 PB - Pensoft Publishers CY - Sofia ER - TY - JOUR A1 - Arntz, Fabian A1 - Mkaouer, Bessem A1 - Markov, Adrian A1 - Schoenfeld, Brad A1 - Moran, Jason A1 - Ramirez-Campillo, Rodrigo A1 - Behrens, Martin A1 - Baumert, Philipp A1 - Erskine, Robert M. A1 - Hauser, Lukas A1 - Chaabene, Helmi T1 - Effect of plyometric jump training on skeletal muscle hypertrophy in healthy individuals BT - a systematic review with multilevel meta-analysis JF - Frontiers in Physiology N2 - Objective: To examine the effect of plyometric jump training on skeletal muscle hypertrophy in healthy individuals. Methods: A systematic literature search was conducted in the databases PubMed, SPORTDiscus, Web of Science, and Cochrane Library up to September 2021. Results: Fifteen studies met the inclusion criteria. The main overall finding (44 effect sizes across 15 clusters median = 2, range = 1–15 effects per cluster) indicated that plyometric jump training had small to moderate effects [standardised mean difference (SMD) = 0.47 (95% CIs = 0.23–0.71); p < 0.001] on skeletal muscle hypertrophy. Subgroup analyses for training experience revealed trivial to large effects in non-athletes [SMD = 0.55 (95% CIs = 0.18–0.93); p = 0.007] and trivial to moderate effects in athletes [SMD = 0.33 (95% CIs = 0.16–0.51); p = 0.001]. Regarding muscle groups, results showed moderate effects for the knee extensors [SMD = 0.72 (95% CIs = 0.66–0.78), p < 0.001] and equivocal effects for the plantar flexors [SMD = 0.65 (95% CIs = −0.25–1.55); p = 0.143]. As to the assessment methods of skeletal muscle hypertrophy, findings indicated trivial to small effects for prediction equations [SMD = 0.29 (95% CIs = 0.16–0.42); p < 0.001] and moderate-to-large effects for ultrasound imaging [SMD = 0.74 (95% CIs = 0.59–0.89); p < 0.001]. Meta-regression analysis indicated that the weekly session frequency moderates the effect of plyometric jump training on skeletal muscle hypertrophy, with a higher weekly session frequency inducing larger hypertrophic gains [β = 0.3233 (95% CIs = 0.2041–0.4425); p < 0.001]. We found no clear evidence that age, sex, total training period, single session duration, or the number of jumps per week moderate the effect of plyometric jump training on skeletal muscle hypertrophy [β = −0.0133 to 0.0433 (95% CIs = −0.0387 to 0.1215); p = 0.101–0.751]. Conclusion: Plyometric jump training can induce skeletal muscle hypertrophy, regardless of age and sex. There is evidence for relatively larger effects in non-athletes compared with athletes. Further, the weekly session frequency seems to moderate the effect of plyometric jump training on skeletal muscle hypertrophy, whereby more frequent weekly plyometric jump training sessions elicit larger hypertrophic adaptations. KW - muscle tissue KW - muscle strength KW - stretch shortening cycle exercise KW - muscle growth KW - human physical conditioning KW - youth sports KW - aged Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.888464 SN - 1664-042X VL - 13 SP - 1 EP - 17 PB - Frontiers CY - Lausanne, Schweiz ET - 888464 ER - TY - JOUR A1 - Agarwal, Saloni A1 - Hamidizadeh, Mojdeh A1 - Bier, Frank Fabian T1 - Detection of reverse transcriptase LAMP-amplified nucleic acid from oropharyngeal viral swab samples using biotinylated DNA probes through a lateral flow assay JF - Biosensors : open access journal N2 - This study focuses on three key aspects: (a) crude throat swab samples in a viral transport medium (VTM) as templates for RT-LAMP reactions; (b) a biotinylated DNA probe with enhanced specificity for LFA readouts; and (c) a digital semi-quantification of LFA readouts. Throat swab samples from SARS-CoV-2 positive and negative patients were used in their crude (no cleaning or pre-treatment) forms for the RT-LAMP reaction. The samples were heat-inactivated but not treated for any kind of nucleic acid extraction or purification. The RT-LAMP (20 min processing time) product was read out by an LFA approach using two labels: FITC and biotin. FITC was enzymatically incorporated into the RT-LAMP amplicon with the LF-LAMP primer, and biotin was introduced using biotinylated DNA probes, specifically for the amplicon region after RT-LAMP amplification. This assay setup with biotinylated DNA probe-based LFA readouts of the RT-LAMP amplicon was 98.11% sensitive and 96.15% specific. The LFA result was further analysed by a smartphone-based IVD device, wherein the T-line intensity was recorded. The LFA T-line intensity was then correlated with the qRT-PCR Ct value of the positive swab samples. A digital semi-quantification of RT-LAMP-LFA was reported with a correlation coefficient of R2 = 0.702. The overall RT-LAMP-LFA assay time was recorded to be 35 min with a LoD of three RNA copies/µL (Ct-33). With these three advancements, the nucleic acid testing-point of care technique (NAT-POCT) is exemplified as a versatile biosensor platform with great potential and applicability for the detection of pathogens without the need for sample storage, transportation, or pre-processing. KW - RT-LAMP KW - LFA KW - NAAT-LFA KW - semi-quantitative KW - surveillance-based diagnostics Y1 - 2023 U6 - https://doi.org/10.3390/bios13110988 SN - 2079-6374 VL - 13 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wittenbecher, Clemens A1 - Cuadrat, Rafael A1 - Johnston, Luke A1 - Eichelmann, Fabian A1 - Jäger, Susanne A1 - Kuxhaus, Olga A1 - Prada, Marcela A1 - Del Greco, Fabiola M. A1 - Hicks, Andrew A. A1 - Hoffman, Per A1 - Krumsiek, Jan A1 - Hu, Frank B. A1 - Schulze, Matthias B. T1 - Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology JF - Nature communications N2 - Metabolic alterations precede cardiometabolic disease onset. Here we present ceramide- and dihydroceramide-profiling data from a nested case-cohort (type 2 diabetes [T2D, n = 775]; cardiovascular disease [CVD, n = 551]; random subcohort [n = 1137]) in the prospective EPIC-Potsdam study. We apply the novel NetCoupler-algorithm to link a data-driven (dihydro)ceramide network to T2D and CVD risk. Controlling for confounding by other (dihydro)ceramides, ceramides C18:0 and C22:0 and dihydroceramides C20:0 and C22:2 are associated with higher and ceramide C20:0 and dihydroceramide C26:1 with lower T2D risk. Ceramide C16:0 and dihydroceramide C22:2 are associated with higher CVD risk. Genome-wide association studies and Mendelian randomization analyses support a role of ceramide C22:0 in T2D etiology. Our results also suggest that (dh)ceramides partly mediate the putative adverse effect of high red meat consumption and benefits of coffee consumption on T2D risk. Thus, (dihydro)ceramides may play a critical role in linking genetic predisposition and dietary habits to cardiometabolic disease risk. Y1 - 2022 U6 - https://doi.org/10.1038/s41467-022-28496-1 SN - 2041-1723 VL - 13 PB - Nature Research CY - Berlin ER - TY - JOUR A1 - DeFelipe, Irene A1 - Alcalde, Juan A1 - Baykiev, Eldar A1 - Bernal, Isabel A1 - Boonma, Kittiphon A1 - Carbonell, Ramon A1 - Flude, Stephanie A1 - Folch, Arnau A1 - Fullea, Javier A1 - García-Castellanos, Daniel A1 - Geyer, Adelina A1 - Giralt, Santiago A1 - Hernández, Armand A1 - Jiménez-Munt, Ivone A1 - Kumar, Ajay A1 - Llorens, Maria-Gema A1 - Martí, Joan A1 - Molina, Cecilia A1 - Olivar-Castaño, Andrés A1 - Parnell, Andrew A1 - Schimmel, Martin A1 - Torné, Montserrat A1 - Ventosa, Sergi T1 - Towards a digital twin of the Earth system: Geo-Soft-CoRe, a geoscientific software & code repository JF - Frontiers in earth science N2 - The immense advances in computer power achieved in the last decades have had a significant impact in Earth science, providing valuable research outputs that allow the simulation of complex natural processes and systems, and generating improved forecasts. The development and implementation of innovative geoscientific software is currently evolving towards a sustainable and efficient development by integrating models of different aspects of the Earth system. This will set the foundation for a future digital twin of the Earth. The codification and update of this software require great effort from research groups and therefore, it needs to be preserved for its reuse by future generations of geoscientists. Here, we report on Geo-Soft-CoRe, a Geoscientific Software & Code Repository, hosted at the archive DIGITAL.CSIC. This is an open source, multidisciplinary and multiscale collection of software and code developed to analyze different aspects of the Earth system, encompassing tools to: 1) analyze climate variability; 2) assess hazards, and 3) characterize the structure and dynamics of the solid Earth. Due to the broad range of applications of these software packages, this collection is useful not only for basic research in Earth science, but also for applied research and educational purposes, reducing the gap between the geosciences and the society. By providing each software and code with a permanent identifier (DOI), we ensure its self-sustainability and accomplish the FAIR (Findable, Accessible, Interoperable and Reusable) principles. Therefore, we aim for a more transparent science, transferring knowledge in an easier way to the geoscience community, and encouraging an integrated use of computational infrastructure. KW - digital twin KW - software KW - code KW - global change KW - hazards KW - solid earth Y1 - 2022 U6 - https://doi.org/10.3389/feart.2022.828005 SN - 2296-6463 VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Groh, Jannis A1 - Diamantopoulos, Efstathios A1 - Duan, Xiaohong A1 - Ewert, Frank A1 - Heinlein, Florian A1 - Herbst, Michael A1 - Holbak, Maja A1 - Kamali, Bahareh A1 - Kersebaum, Kurt-Christian A1 - Kuhnert, Matthias A1 - Nendel, Claas A1 - Priesack, Eckart A1 - Steidl, Jörg A1 - Sommer, Michael A1 - Pütz, Thomas A1 - Vanderborght, Jan A1 - Vereecken, Harry A1 - Wallor, Evelyn A1 - Weber, Tobias K. D. A1 - Wegehenkel, Martin A1 - Weihermüller, Lutz A1 - Gerke, Horst H. T1 - Same soil, different climate: Crop model intercomparison on translocated lysimeters JF - Vadose zone journal N2 - Crop model intercomparison studies have mostly focused on the assessment of predictive capabilities for crop development using weather and basic soil data from the same location. Still challenging is the model performance when considering complex interrelations between soil and crop dynamics under a changing climate. The objective of this study was to test the agronomic crop and environmental flux-related performance of a set of crop models. The aim was to predict weighing lysimeter-based crop (i.e., agronomic) and water-related flux or state data (i.e., environmental) obtained for the same soil monoliths that were taken from their original environment and translocated to regions with different climatic conditions, after model calibration at the original site. Eleven models were deployed in the study. The lysimeter data (2014-2018) were from the Dedelow (Dd), Bad Lauchstadt (BL), and Selhausen (Se) sites of the TERENO (TERrestrial ENvironmental Observatories) SOILCan network. Soil monoliths from Dd were transferred to the drier and warmer BL site and the wetter and warmer Se site, which allowed a comparison of similar soil and crop under varying climatic conditions. The model parameters were calibrated using an identical set of crop- and soil-related data from Dd. Environmental fluxes and crop growth of Dd soil were predicted for conditions at BL and Se sites using the calibrated models. The comparison of predicted and measured data of Dd lysimeters at BL and Se revealed differences among models. At site BL, the crop models predicted agronomic and environmental components similarly well. Model performance values indicate that the environmental components at site Se were better predicted than agronomic ones. The multi-model mean was for most observations the better predictor compared with those of individual models. For Se site conditions, crop models failed to predict site-specific crop development indicating that climatic conditions (i.e., heat stress) were outside the range of variation in the data sets considered for model calibration. For improving predictive ability of crop models (i.e., productivity and fluxes), more attention should be paid to soil-related data (i.e., water fluxes and system states) when simulating soil-crop-climate interrelations in changing climatic conditions. Y1 - 2022 U6 - https://doi.org/10.1002/vzj2.20202 SN - 1539-1663 VL - 21 IS - 4 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Kühne, Katharina A1 - Herbold, Erika A1 - Bendel, Oliver A1 - Zhou, Yuefang A1 - Fischer, Martin H. T1 - “Ick bin een Berlina” BT - dialect proficiency impacts a robot’s trustworthiness and competence evaluation JF - Frontiers in robotics and AI N2 - Background: Robots are increasingly used as interaction partners with humans. Social robots are designed to follow expected behavioral norms when engaging with humans and are available with different voices and even accents. Some studies suggest that people prefer robots to speak in the user’s dialect, while others indicate a preference for different dialects. Methods: Our study examined the impact of the Berlin dialect on perceived trustworthiness and competence of a robot. One hundred and twenty German native speakers (Mage = 32 years, SD = 12 years) watched an online video featuring a NAO robot speaking either in the Berlin dialect or standard German and assessed its trustworthiness and competence. Results: We found a positive relationship between participants’ self-reported Berlin dialect proficiency and trustworthiness in the dialect-speaking robot. Only when controlled for demographic factors, there was a positive association between participants’ dialect proficiency, dialect performance and their assessment of robot’s competence for the standard German-speaking robot. Participants’ age, gender, length of residency in Berlin, and device used to respond also influenced assessments. Finally, the robot’s competence positively predicted its trustworthiness. Discussion: Our results inform the design of social robots and emphasize the importance of device control in online experiments. KW - competence KW - dialect KW - human-robot interaction KW - robot voice KW - social robot KW - trust Y1 - 2024 U6 - https://doi.org/10.3389/frobt.2023.1241519 SN - 2296-9144 VL - 10 PB - Frontiers Media S.A. CY - Lausanne ER - TY - JOUR A1 - Petrov, Polina A1 - Singer, Leo P. A1 - Coughlin, Michael W. A1 - Kumar, Vishwesh A1 - Almualla, Mouza A1 - Anand, Shreya A1 - Bulla, Mattia A1 - Dietrich, Tim A1 - Foucart, Francois A1 - Guessoum, Nidhal T1 - Data-driven expectations for electromagnetic counterpart searches based on LIGO/Virgo public alerts JF - The astrophysical journal : an international review of spectroscopy and astronomical physics; part 1 N2 - Searches for electromagnetic counterparts of gravitational-wave signals have redoubled since the first detection in 2017 of a binary neutron star merger with a gamma-ray burst, optical/infrared kilonova, and panchromatic afterglow. Yet, one LIGO/Virgo observing run later, there has not yet been a second, secure identification of an electromagnetic counterpart. This is not surprising given that the localization uncertainties of events in LIGO and Virgo's third observing run, O3, were much larger than predicted. We explain this by showing that improvements in data analysis that now allow LIGO/Virgo to detect weaker and hence more poorly localized events have increased the overall number of detections, of which well-localized, gold-plated events make up a smaller proportion overall. We present simulations of the next two LIGO/Virgo/KAGRA observing runs, O4 and O5, that are grounded in the statistics of O3 public alerts. To illustrate the significant impact that the updated predictions can have, we study the follow-up strategy for the Zwicky Transient Facility. Realistic and timely forecasting of gravitational-wave localization accuracy is paramount given the large commitments of telescope time and the need to prioritize which events are followed up. We include a data release of our simulated localizations as a public proposal planning resource for astronomers. Y1 - 2022 U6 - https://doi.org/10.3847/1538-4357/ac366d SN - 1538-4357 VL - 924 IS - 2 PB - Institute of Physics Publ. CY - London ER - TY - JOUR A1 - Döbbeling-Hildebrandt, Niklas A1 - Miersch, Klaas A1 - Khanna, Tarun M. A1 - Bachelet, Marion A1 - Bruns, Stephan B. A1 - Callaghan, Max A1 - Edenhofer, Ottmar A1 - Flachsland, Christian A1 - Forster, Piers M. A1 - Kalkuhl, Matthias A1 - Koch, Nicolas A1 - Lamb, William F. A1 - Ohlendorf, Nils A1 - Steckel, Jan Christoph A1 - Minx, Jan C. T1 - Systematic review and meta-analysis of ex-post evaluations on the effectiveness of carbon pricing JF - Nature communications N2 - Today, more than 70 carbon pricing schemes have been implemented around the globe, but their contributions to emissions reductions remains a subject of heated debate in science and policy. Here we assess the effectiveness of carbon pricing in reducing emissions using a rigorous, machine-learning assisted systematic review and meta-analysis. Based on 483 effect sizes extracted from 80 causal ex-post evaluations across 21 carbon pricing schemes, we find that introducing a carbon price has yielded immediate and substantial emission reductions for at least 17 of these policies, despite the low level of prices in most instances. Statistically significant emissions reductions range between –5% to –21% across the schemes (–4% to –15% after correcting for publication bias). Our study highlights critical evidence gaps with regard to dozens of unevaluated carbon pricing schemes and the price elasticity of emissions reductions. More rigorous synthesis of carbon pricing and other climate policies is required across a range of outcomes to advance our understanding of “what works” and accelerate learning on climate solutions in science and policy. KW - carbon and energy KW - climate-change mitigation KW - climate-change policy KW - economics Y1 - 2024 U6 - https://doi.org/10.1038/s41467-024-48512-w SN - 2041-1723 VL - 15 IS - 1 PB - Springer Nature CY - London ER - TY - JOUR A1 - Tchewonpi Sagu, Sorel A1 - Landgräber, Eva A1 - Henkel, Ina M. A1 - Huschek, Gerd A1 - Homann, Thomas A1 - Bußler, Sara A1 - Schlüter, Oliver A1 - Rawel, Harshadrai Manilal T1 - Effect of cereal α-amylase/trypsin inhibitors on developmental characteristics and abundance of digestive enzymes of mealworm larvae (Tenebrio molitor L.) JF - Insects : open access journal N2 - The objective of this work was to investigate the potential effect of cereal α-amylase/trypsin inhibitors (ATIs) on growth parameters and selective digestive enzymes of Tenebrio molitor L. larvae. The approach consisted of feeding the larvae with wheat, sorghum and rice meals containing different levels and composition of α-amylase/trypsin inhibitors. The developmental and biochemical characteristics of the larvae were assessed over feeding periods of 5 h, 5 days and 10 days, and the relative abundance of α-amylase and selected proteases in larvae were determined using liquid chromatography tandem mass spectrometry. Overall, weight gains ranged from 21% to 42% after five days of feeding. The larval death rate significantly increased in all groups after 10 days of feeding (p < 0.05), whereas the pupation rate was about 25% among larvae fed with rice (Oryza sativa L.) and Siyazan/Esperya wheat meals, and only 8% and 14% among those fed with Damougari and S35 sorghum meals. As determined using the Lowry method, the protein contents of the sodium phosphate extracts ranged from 7.80 ± 0.09 to 9.42 ± 0.19 mg/mL and those of the ammonium bicarbonate/urea reached 19.78 ± 0.16 to 37.47 ± 1.38 mg/mL. The total protein contents of the larvae according to the Kjeldahl method ranged from 44.0 and 49.9 g/100 g. The relative abundance of α-amylase, CLIP domain-containing serine protease, modular serine protease zymogen and C1 family cathepsin significantly decreased in the larvae, whereas dipeptidylpeptidase I and chymotrypsin increased within the first hours after feeding (p < 0.05). Trypsin content was found to be constant independently of time or feed material. Finally, based on the results we obtained, it was difficult to substantively draw conclusions on the likely effects of meal ATI composition on larval developmental characteristics, but their effects on the digestive enzyme expression remain relevant. KW - growth behavior KW - Tenebrio molitor larvae KW - feeding KW - cereal meals KW - α-amylase KW - digestive enzymes quantification KW - LC-MS/MS KW - trypsin inhibitors Y1 - 2021 U6 - https://doi.org/10.3390/insects12050454 SN - 2075-4450 VL - 12 IS - 5 PB - MDPI CY - Basel ER -