TY - JOUR A1 - van Soest, Heleen L. A1 - Aleluia Reis, Lara A1 - Baptista, Luiz Bernardo A1 - Bertram, Christoph A1 - Després, Jacques A1 - Drouet, Laurent A1 - den Elzen, Michel A1 - Fragkos, Panagiotis A1 - Fricko, Oliver A1 - Fujimori, Shinichiro A1 - Grant, Neil A1 - Harmsen, Mathijs A1 - Iyer, Gokul A1 - Keramidas, Kimon A1 - Köberle, Alexandre C. A1 - Kriegler, Elmar A1 - Malik, Aman A1 - Mittal, Shivika A1 - Oshiro, Ken A1 - Riahi, Keywan A1 - Roelfsema, Mark A1 - van Ruijven, Bas A1 - Schaeffer, Roberto A1 - Silva Herran, Diego A1 - Tavoni, Massimo A1 - Ünlü, Gamze A1 - Vandyck, Toon A1 - van Vuuren, Detlef P. T1 - Global roll-out of comprehensive policy measures may aid in bridging emissions gap JF - Nature communications N2 - Closing the emissions gap between Nationally Determined Contributions (NDCs) and the global emissions levels needed to achieve the Paris Agreement’s climate goals will require a comprehensive package of policy measures. National and sectoral policies can help fill the gap, but success stories in one country cannot be automatically replicated in other countries. They need to be adapted to the local context. Here, we develop a new Bridge scenario based on nationally relevant, short-term measures informed by interactions with country experts. These good practice policies are rolled out globally between now and 2030 and combined with carbon pricing thereafter. We implement this scenario with an ensemble of global integrated assessment models. We show that the Bridge scenario closes two-thirds of the emissions gap between NDC and 2 °C scenarios by 2030 and enables a pathway in line with the 2 °C goal when combined with the necessary long-term changes, i.e. more comprehensive pricing measures after 2030. The Bridge scenario leads to a scale-up of renewable energy (reaching 52%–88% of global electricity supply by 2050), electrification of end-uses, efficiency improvements in energy demand sectors, and enhanced afforestation and reforestation. Our analysis suggests that early action via good-practice policies is less costly than a delay in global climate cooperation. KW - climate-change mitigation KW - climate-change policy Y1 - 2021 U6 - https://doi.org/10.1038/s41467-021-26595-z VL - 12 IS - 1 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Ye, Fangyuan A1 - Zhang, Shuo A1 - Warby, Jonathan A1 - Wu, Jiawei A1 - Gutierrez-Partida, Emilio A1 - Lang, Felix A1 - Shah, Sahil A1 - Saglamkaya, Elifnaz A1 - Sun, Bowen A1 - Zu, Fengshuo A1 - Shoai, Safa A1 - Wang, Haifeng A1 - Stiller, Burkhard A1 - Neher, Dieter A1 - Zhu, Wei-Hong A1 - Stolterfoht, Martin A1 - Wu, Yongzhen T1 - Overcoming C₆₀-induced interfacial recombination in inverted perovskite solar cells by electron-transporting carborane JF - Nature Communications N2 - Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C₆₀ interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C₆₀ interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23% with a low non-radiative voltage loss of 110 mV, and retain >97% of the initial efficiency after 400 h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells. Y1 - 2022 U6 - https://doi.org/10.1038/s41467-022-34203-x SN - 2041-1723 VL - 13 IS - 1 PB - Springer Nature CY - London ER - TY - BOOK ED - Löw, Martina ED - Sayman, Volkan ED - Schwerer, Jona ED - Wolf, Hannah T1 - Am Ende der Globalisierung BT - über die Refiguration von Räumen T3 - Re-Figuration von Räumen N2 - Die Globalisierung ist zur allgegenwärtigen Gewissheit geworden. Doch wie zutreffend ist das Konzept »Globalisierung«, wenn zeitgleich nationale Grenzen gestärkt und transnationale Freihandelszonen ausgeweitet werden, wenn auf unterschiedlichen scales Territorien überwunden und zugleich territoriale Abgrenzungen neu gesetzt werden? Aktuelle Veränderungen als Re-Figuration von Räumen zu verstehen, ermöglicht die Analyse und Diskussion widersprüchlicher, spannungsreicher und konflikthafter räumlicher Prozesse und ihrer alltäglichen Erfahrung. Die interdisziplinären Beiträge des Bandes liefern theoretische und empirische Analysen zu politischen, digitalen und alltäglichen Räumen im Konzept der Re-Figuration. KW - Globalisierung KW - Raum KW - Re-Figuration KW - Moderne KW - Sicherheit KW - Stadt KW - Land KW - Nationalstaat KW - Europa KW - Wissen KW - Grenze KW - Digitale Planung KW - Smart City KW - Öffentlichkeit KW - Medien KW - Migration KW - Tourismus KW - Berlin KW - Wandel KW - Lebensmittel KW - Materialität KW - Soziologische Theorie KW - Soziologie KW - globalization KW - space KW - modernity KW - security KW - city KW - country KW - nation-state KW - europe KW - knowledge KW - border KW - digital planning KW - public sphere KW - media KW - tourism KW - change KW - foods KW - materiality KW - sociological theory KW - sociology Y1 - 2021 SN - 978-3-8376-5402-8 SN - 978-3-8394-5402-2 U6 - https://doi.org/10.14361/9783839454022 VL - 1 PB - transcript CY - Bielefeld ER - TY - JOUR A1 - Ehrig, Lukas A1 - Wagner, Ann-Christin A1 - Wolter, Heike A1 - Correll, Christoph U. A1 - Geisel, Olga A1 - Konigorski, Stefan T1 - FASDetect as a machine learning-based screening app for FASD in youth with ADHD JF - npj Digital Medicine N2 - Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de. KW - Medical research KW - Psychiatric disorders Y1 - 2023 U6 - https://doi.org/10.1038/s41746-023-00864-1 SN - 2398-6352 VL - 6 IS - 1 PB - Macmillan Publishers Limited CY - Basingstoke ER - TY - JOUR A1 - Slosarek, Tamara A1 - Ibing, Susanne A1 - Schormair, Barbara A1 - Heyne, Henrike A1 - Böttinger, Erwin A1 - Andlauer, Till A1 - Schurmann, Claudia T1 - Implementation and evaluation of personal genetic testing as part of genomics analysis courses in German universities JF - BMC Medical Genomics N2 - Purpose Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM). Methods We compared and evaluated the courses and the students ' perceptions on the course setup using questionnaires. Results During the course, students changed their attitudes towards genotyping (HPI: 79% [15 of 19], TUM: 47% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73% [11 of 15], TUM: 72% [18 of 25]) and most students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79% [15 of 19], TUM: 70% [37 of 53]). Students found the personal genotyping component useful (HPI: 89% [17 of 19], TUM: 92% [49 of 53]) and recommended its inclusion in future courses (HPI: 95% [18 of 19], TUM: 98% [52 of 53]). Conclusion Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe. KW - Genomics education KW - Personal genotyping KW - Personalized medicine Y1 - 2023 U6 - https://doi.org/10.1186/s12920-023-01503-0 SN - 1755-8794 VL - 16 IS - 1 PB - BMC CY - London ER - TY - CHAP A1 - Rieskamp, Jonas A1 - Mirbabaie, Milad A1 - Hofeditz, Lennart A1 - Vischedyk, Justin T1 - Conversational agents and their influence on the well-being of cliniciansclinicians T2 - ACIS 2023 proceedings N2 - An increasing number of clinicians (i.e., nurses and physicians) suffer from mental health-related issues like depression and burnout. These, in turn, stress communication, collaboration, and decision- making—areas in which Conversational Agents (CAs) have shown to be useful. Thus, in this work, we followed a mixed-method approach and systematically analysed the literature on factors affecting the well-being of clinicians and CAs’ potential to improve said well-being by relieving support in communication, collaboration, and decision-making in hospitals. In this respect, we are guided by Brigham et al. (2018)’s model of factors influencing well-being. Based on an initial number of 840 articles, we further analysed 52 papers in more detail and identified the influences of CAs’ fields of application on external and individual factors affecting clinicians’ well-being. As our second method, we will conduct interviews with clinicians and experts on CAs to verify and extend these influencing factors. KW - conversational agents KW - well-being KW - mental health KW - hospitals KW - clinicians Y1 - 2023 UR - https://aisel.aisnet.org/acis2023/66 PB - Australasian Association for Information Systems CY - Wellington ER - TY - JOUR A1 - Seroussi, Helene A1 - Nowicki, Sophie A1 - Simon, Erika A1 - Abe-Ouchi, Ayako A1 - Albrecht, Torsten A1 - Brondex, Julien A1 - Cornford, Stephen A1 - Dumas, Christophe A1 - Gillet-Chaulet, Fabien A1 - Goelzer, Heiko A1 - Golledge, Nicholas R. A1 - Gregory, Jonathan M. A1 - Greve, Ralf A1 - Hoffman, Matthew J. A1 - Humbert, Angelika A1 - Huybrechts, Philippe A1 - Kleiner, Thomas A1 - Larourl, Eric A1 - Leguy, Gunter A1 - Lipscomb, William H. A1 - Lowry, Daniel A1 - Mengel, Matthias A1 - Morlighem, Mathieu A1 - Pattyn, Frank A1 - Payne, Anthony J. A1 - Pollard, David A1 - Price, Stephen F. A1 - Quiquet, Aurelien A1 - Reerink, Thomas J. A1 - Reese, Ronja A1 - Rodehacke, Christian B. A1 - Schlegel, Nicole-Jeanne A1 - Shepherd, Andrew A1 - Sun, Sainan A1 - Sutter, Johannes A1 - Van Breedam, Jonas A1 - van de Wal, Roderik S. W. A1 - Winkelmann, Ricarda A1 - Zhang, Tong T1 - initMIP-Antarctica BT - an ice sheet model initialization experiment of ISMIP6 JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Ice sheet numerical modeling is an important tool to estimate the dynamic contribution of the Antarctic ice sheet to sea level rise over the coming centuries. The influence of initial conditions on ice sheet model simulations, however, is still unclear. To better understand this influence, an initial state intercomparison exercise (initMIP) has been developed to compare, evaluate, and improve initialization procedures and estimate their impact on century-scale simulations. initMlP is the first set of experiments of the Ice Sheet Model Intercomparison Project for CMIP6 (ISMIP6), which is the primary Coupled Model Intercomparison Project Phase 6 (CMIP6) activity focusing on the Greenland and Antarctic ice sheets. Following initMlP-Greenland, initMlP-Antarctica has been designed to explore uncertainties associated with model initialization and spin-up and to evaluate the impact of changes in external forcings. Starting from the state of the Antarctic ice sheet at the end of the initialization procedure, three forward experiments are each run for 100 years: a control run, a run with a surface mass balance anomaly, and a run with a basal melting anomaly beneath floating ice. This study presents the results of initMlP-Antarctica from 25 simulations performed by 16 international modeling groups. The submitted results use different initial conditions and initialization methods, as well as ice flow model parameters and reference external forcings. We find a good agreement among model responses to the surface mass balance anomaly but large variations in responses to the basal melting anomaly. These variations can be attributed to differences in the extent of ice shelves and their upstream tributaries, the numerical treatment of grounding line, and the initial ocean conditions applied, suggesting that ongoing efforts to better represent ice shelves in continental-scale models should continue. Y1 - 2019 U6 - https://doi.org/10.5194/tc-13-1441-2019 SN - 1994-0416 SN - 1994-0424 VL - 13 IS - 5 SP - 1441 EP - 1471 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Reese, Ronja A1 - Albrecht, Torsten A1 - Mengel, Matthias A1 - Asay-Davis, Xylar A1 - Winkelmann, Ricarda T1 - Antarctic sub-shelf melt rates via PICO JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Ocean-induced melting below ice shelves is one of the dominant drivers for mass loss from the Antarctic Ice Sheet at present. An appropriate representation of sub-shelf melt rates is therefore essential for model simulations of marine-based ice sheet evolution. Continental-scale ice sheet models often rely on simple melt-parameterizations, in particular for long-term simulations, when fully coupled ice-ocean interaction becomes computationally too expensive. Such parameterizations can account for the influence of the local depth of the ice-shelf draft or its slope on melting. However, they do not capture the effect of ocean circulation underneath the ice shelf. Here we present the Potsdam Ice-shelf Cavity mOdel (PICO), which simulates the vertical overturning circulation in ice-shelf cavities and thus enables the computation of sub-shelf melt rates consistent with this circulation. PICO is based on an ocean box model that coarsely resolves ice shelf cavities and uses a boundary layer melt formulation. We implement it as a module of the Parallel Ice Sheet Model (PISM) and evaluate its performance under present-day conditions of the Southern Ocean. We identify a set of parameters that yield two-dimensional melt rate fields that qualitatively reproduce the typical pattern of comparably high melting near the grounding line and lower melting or refreezing towards the calving front. PICO captures the wide range of melt rates observed for Antarctic ice shelves, with an average of about 0.1 ma(-1) for cold sub-shelf cavities, for example, underneath Ross or Ronne ice shelves, to 16 ma(-1) for warm cavities such as in the Amundsen Sea region. This makes PICO a computationally feasible and more physical alternative to melt parameterizations purely based on ice draft geometry. Y1 - 2018 U6 - https://doi.org/10.5194/tc-12-1969-2018 SN - 1994-0416 SN - 1994-0424 VL - 12 IS - 6 SP - 1969 EP - 1985 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Reese, Ronja A1 - Winkelmann, Ricarda A1 - Gudmundsson, Gudmundur Hilmar T1 - Grounding-line flux formula applied as a flux condition in numerical simulations fails for buttressed Antarctic ice streams JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Currently, several large-scale ice-flow models impose a condition on ice flux across grounding lines using an analytically motivated parameterisation of grounding-line flux. It has been suggested that employing this analytical expression alleviates the need for highly resolved computational domains around grounding lines of marine ice sheets. While the analytical flux formula is expected to be accurate in an unbuttressed flow-line setting, its validity has hitherto not been assessed for complex and realistic geometries such as those of the Antarctic Ice Sheet. Here the accuracy of this analytical flux formula is tested against an optimised ice flow model that uses a highly resolved computational mesh around the Antarctic grounding lines. We find that when applied to the Antarctic Ice Sheet the analytical expression provides inaccurate estimates of ice fluxes for almost all grounding lines. Furthermore, in many instances direct application of the analytical formula gives rise to unphysical complex-valued ice fluxes. We conclude that grounding lines of the Antarctic Ice Sheet are, in general, too highly buttressed for the analytical parameterisation to be of practical value for the calculation of grounding-line fluxes. Y1 - 2018 U6 - https://doi.org/10.5194/tc-12-3229-2018 SN - 1994-0416 SN - 1994-0424 VL - 12 IS - 10 SP - 3229 EP - 3242 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Ciemer, Catrin A1 - Rehm, Lars A1 - Kurths, Jürgen A1 - Donner, Reik Volker A1 - Winkelmann, Ricarda A1 - Boers, Niklas T1 - An early-warning indicator for Amazon droughts exclusively based on tropical Atlantic sea surface temperatures JF - Environmental Research Letters N2 - Droughts in tropical South America have an imminent and severe impact on the Amazon rainforest and affect the livelihoods of millions of people. Extremely dry conditions in Amazonia have been previously linked to sea surface temperature (SST) anomalies in the adjacent tropical oceans. Although the sources and impacts of such droughts have been widely studied, establishing reliable multi-year lead statistical forecasts of their occurrence is still an ongoing challenge. Here, we further investigate the relationship between SST and rainfall anomalies using a complex network approach. We identify four ocean regions which exhibit the strongest overall SST correlations with central Amazon rainfall, including two particularly prominent regions in the northern and southern tropical Atlantic. Based on the time-dependent correlation between SST anomalies in these two regions alone, we establish a new early-warning method for droughts in the central Amazon basin and demonstrate its robustness in hindcasting past major drought events with lead-times up to 18 months. KW - complex networks KW - droughts KW - prediction KW - Amazon rainforest Y1 - 2019 VL - 15 IS - 9 PB - IOP - Institute of Physics Publishing CY - Bristol ER -