TY  - JOUR
A1  - Deeken, Friederike
A1  - Reichert, Markus
A1  - Zech, Hilmar
A1  - Wenzel, Julia
A1  - Wedemeyer, Friederike
A1  - Aguilera, Alvaro
A1  - Aslan, Acelya
A1  - Bach, Patrick
A1  - Bahr, Nadja Samia
A1  - Ebrahimi, Claudia
A1  - Fischbach, Pascale Christine
A1  - Ganz, Marvin
A1  - Garbusow, Maria
A1  - Großkopf, Charlotte M.
A1  - Heigert, Marie
A1  - Hentschel, Angela
A1  - Karl, Damian
A1  - Pelz, Patricia
A1  - Pinger, Mathieu
A1  - Riemerschmid, Carlotta
A1  - Rosenthal, Annika
A1  - Steffen, Johannes
A1  - Strehle, Jens
A1  - Weiss,, Franziska
A1  - Wieder, Gesine
A1  - Wieland, Alfred
A1  - Zaiser, Judith
A1  - Zimmermann, Sina
A1  - Walter, Henrik
A1  - Lenz, Bernd
A1  - Deserno, Lorenz
A1  - Smolka, Michael N.
A1  - Liu, Shuyan
A1  - Ebner-Priemer, Ulrich Walter
A1  - Heinz, Andreas
A1  - Rapp, Michael A.
T1  - Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany
JF  - JAMA Network Open
N2  - Importance  Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence.

Objective  To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms.

Design, Setting, and Participants  This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021).

Main Outcomes and Measures  Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates.

Results  Of the 1743 screened participants, 189 (119 [63.0%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95% CI, 21.87-31.77; P < .001) and New Year’s Eve (β = 66.88; 95% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = −5.45; 95% CI, −8.00 to −2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = −11.10; 95% CI, −13.63 to −8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = −6.14; 95% CI, −9.96 to −2.31; P = .002) and in participants with severe AUD (β = −6.26; 95% CI, −10.18 to −2.34; P = .002).

Conclusions and Relevance  This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.
Y1  - 2022
U6  - https://doi.org/10.1001/jamanetworkopen.2022.24641
SN  - 2574-3805
VL  - 5
SP  - 1
EP  - 11
PB  - JAMA Network / American Medical Association
CY  - Chicago, Illinois, USA
ET  - 8
ER  - 
TY  - JOUR
A1  - Brahms, Markus
A1  - Heinzel, Stephan
A1  - Rapp, Michael A.
A1  - Mückstein, Marie
A1  - Hortobágyi, Tibor
A1  - Stelzel, Christine
A1  - Granacher, Urs
T1  - The acute effects of mental fatigue on balance performance in healthy young and older adults – A systematic review and meta-analysis
JF  - Acta Psychologica
N2  - Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task.

We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance.

We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = −0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically.

Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.
KW  - Cognitive fatigue
KW  - Exertion
KW  - Tiredness
KW  - Postural control
KW  - Gait
KW  - Sway
Y1  - 2022
U6  - https://doi.org/10.1016/j.actpsy.2022.103540
SN  - 1873-6297
VL  - 225
SP  - 1
EP  - 13
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Clausen, Sünje
A1  - Brünker, Felix
A1  - Stieglitz, Stefan
T1  - Towards responsible augmentation
BT  - identifying characteristics of AI-based technology with ethical implications for knowledge workers
T2  - ACIS 2023 proceedings
N2  - Artificial intelligence (AI)-based technologies can increasingly perform knowledge work tasks, such as medical diagnosis. Thereby, it is expected that humans will not be replaced by AI but work closely with AI-based technology (“augmentation”). Augmentation has ethical implications for humans (e.g., impact on autonomy, opportunities to flourish through work), thus, developers and managers of AI-based technology have a responsibility to anticipate and mitigate risks to human workers. However, doing so can be difficult as AI encompasses a wide range of technologies, some of which enable fundamentally new forms of interaction. In this research-in-progress paper, we propose the development of a taxonomy to categorize unique characteristics of AI-based technology that influence the interaction and have ethical implications for human workers. The completed taxonomy will support researchers in forming cumulative knowledge on the ethical implications of augmentation and assist practitioners in the ethical design and management of AI-based technology in knowledge work.
KW  - artificial intelligence
KW  - augmentation
KW  - taxonomy
KW  - human-AI interaction
KW  - ethics
Y1  - 2023
UR  - https://aisel.aisnet.org/acis2023/123/
PB  - Australasian Association for Information Systems
CY  - Wellington
ER  - 
TY  - JOUR
A1  - Agthe, Maria
A1  - Kayser, Daniela Niesta
A1  - Schwarz, Sascha
A1  - Maner, Jon K.
T1  - Antecedents of the red-romance effect
BT  - men's attractiveness and women's fertility
JF  - PLOS ONE / Public Library of Science
N2  - The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.
Y1  - 2023
U6  - https://doi.org/10.1371/journal.pone.0284035
SN  - 1932-6203
VL  - 18
IS  - 4
PB  - PLOS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Schmicker, Marlen
A1  - Frühling, Insa
A1  - Menze, Inga
A1  - Glanz, Wenzel
A1  - Müller, Patrick
A1  - Noesselt, Toemme
A1  - Müller, Notger Germar
T1  - The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline
JF  - Journal of Alzheimer's disease reports : JADR
N2  - Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit. 

Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. 

Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. 

Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients.

Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.
KW  - Alzheimer's disease
KW  - dementia
KW  - diagnostic marker
KW  - early diagnosis
KW  - subjective cognitive decline
KW  - taste
Y1  - 2023
U6  - https://doi.org/10.3233/ADR220092
SN  - 2542-4823
VL  - 7
IS  - 1
SP  - 249
EP  - 262
PB  - IOS Press
CY  - Clifton, VA
ER  - 
TY  - JOUR
A1  - Xiong, Yingquan
A1  - Delic, Denis
A1  - Zeng, Shufei
A1  - Chen, Xin
A1  - Chu, Chang
A1  - Hasan, Ahmed A.
A1  - Krämer, Bernhard K.
A1  - Klein, Thomas
A1  - Yin, Lianghong
A1  - Hocher, Berthold
T1  - Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker
JF  - BMC nephrology
N2  - Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocking agents can be safely used during a SARS-CoV-2 infection but it is unknown if DPP-4 inhibitors or SGLT2-blockers may promote COVID-19 by increasing the host viral entry enzymes ACE2 and TMPRSS2. Methods We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model. In the present study, the gene expression of Ace2, Tmprss2, Ren, Agtr2 and Agt was assessed with qRT-PCR and the protein expression of ACE2 and TMPRSS2 with immunohistochemistry in the following experimental groups: Sham + normal diet (ND) + placebo (PBO); 5/6Nx + ND + PBO; 5/6Nx + high salt-diet (HSD) + PBO; 5/6Nx + HSD + telmisartan; 5/6Nx + HSD + linagliptin; 5/6Nx + HSD + empagliflozin. Results In the kidney, the expression of Ace2 was not altered on mRNA level under disease and treatment conditions. The renal TMPRSS2 levels (mRNA and protein) were not affected, whereas the cardiac level was significantly increased in 5/6Nx rats. Intriguingly, the elevated TMPRSS2 protein expression in the heart was significantly normalized after treatment with telmisartan, linagliptin and empagliflozin. Conclusions Our study indicated that there is no upregulation regarding host factors potentially promoting SARS-CoV-2 virus entry into host cells when the SGLT2-blocker empagliflozin, telmisartan and the DPP4-inhibitor blocker linagliptin are used. The results obtained in a preclinical, experimental non-diabetic kidney failure model need confirmation in ongoing interventional clinical trials.
KW  - SARS CoV-2 host factors
KW  - 5/6 nephrectomy
KW  - High-salt diet
KW  - ARB
KW  - DPP4 inhibitor
KW  - SGLT2 blocker
Y1  - 2022
U6  - https://doi.org/10.1186/s12882-022-02747-1
SN  - 1471-2369
VL  - 23
IS  - 1
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Shams, Boshra
A1  - Wang, Ziqian
A1  - Roine, Timo
A1  - Aydogan, Dogu Baran
A1  - Vajkoczy, Peter
A1  - Lippert, Christoph
A1  - Picht, Thomas
A1  - Fekonja, Lucius Samo
T1  - Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract
JF  - Brain communications
N2  - Shams et al. report that glioma patients' motor status is predicted accurately by diffusion MRI metrics along the corticospinal tract based on support vector machine method, reaching an overall accuracy of 77%. They show that these metrics are more effective than demographic and clinical variables. 

Along tract statistics enables white matter characterization using various diffusion MRI metrics. These diffusion models reveal detailed insights into white matter microstructural changes with development, pathology and function. Here, we aim at assessing the clinical utility of diffusion MRI metrics along the corticospinal tract, investigating whether motor glioma patients can be classified with respect to their motor status. We retrospectively included 116 brain tumour patients suffering from either left or right supratentorial, unilateral World Health Organization Grades II, III and IV gliomas with a mean age of 53.51 +/- 16.32 years. Around 37% of patients presented with preoperative motor function deficits according to the Medical Research Council scale. At group level comparison, the highest non-overlapping diffusion MRI differences were detected in the superior portion of the tracts' profiles. Fractional anisotropy and fibre density decrease, apparent diffusion coefficient axial diffusivity and radial diffusivity increase. To predict motor deficits, we developed a method based on a support vector machine using histogram-based features of diffusion MRI tract profiles (e.g. mean, standard deviation, kurtosis and skewness), following a recursive feature elimination method. Our model achieved high performance (74% sensitivity, 75% specificity, 74% overall accuracy and 77% area under the curve). We found that apparent diffusion coefficient, fractional anisotropy and radial diffusivity contributed more than other features to the model. Incorporating the patient demographics and clinical features such as age, tumour World Health Organization grade, tumour location, gender and resting motor threshold did not affect the model's performance, revealing that these features were not as effective as microstructural measures. These results shed light on the potential patterns of tumour-related microstructural white matter changes in the prediction of functional deficits.
KW  - machine learning
KW  - support vector machine
KW  - tractography
KW  - diffusion MRI;
KW  - corticospinal tract
Y1  - 2022
U6  - https://doi.org/10.1093/braincomms/fcac141
SN  - 2632-1297
VL  - 4
IS  - 3
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - de Carvalho Souza, Alyson Matheus
A1  - Barrocas, Roberta
A1  - Fischer, Martin H.
A1  - Arnaud, Emanuel
A1  - Moeller, Korbinian
A1  - Rennó-Costa, César
T1  - Combining virtual reality and tactile stimulation to investigate embodied finger-based numerical representations
JF  - Frontiers in psychology / Frontiers Research Foundation
N2  - Finger-based representation of numbers is a high-level cognitive strategy to assist numerical and arithmetic processing in children and adults. It is unclear whether this paradigm builds on simple perceptual features or comprises several attributes through embodiment. Here we describe the development and initial testing of an experimental setup to study embodiment during a finger-based numerical task using Virtual Reality (VR) and a low-cost tactile stimulator that is easy to build. Using VR allows us to create new ways to study finger-based numerical representation using a virtual hand that can be manipulated in ways our hand cannot, such as decoupling tactile and visual stimuli. The goal is to present a new methodology that can allow researchers to study embodiment through this new approach, maybe shedding new light on the cognitive strategy behind the finger-based representation of numbers. In this case, a critical methodological requirement is delivering precisely targeted sensory stimuli to specific effectors while simultaneously recording their behavior and engaging the participant in a simulated experience. We tested the device's capability by stimulating users in different experimental configurations. Results indicate that our device delivers reliable tactile stimulation to all fingers of a participant's hand without losing motion tracking quality during an ongoing task. This is reflected by an accuracy of over 95% in participants detecting stimulation of a single finger or multiple fingers in sequential stimulation as indicated by experiments with sixteen participants. We discuss possible application scenarios, explain how to apply our methodology to study the embodiment of finger-based numerical representations and other high-level cognitive functions, and discuss potential further developments of the device based on the data obtained in our testing.
KW  - virtual reality
KW  - numerical cognition
KW  - finger counting
KW  - embodied cognition
KW  - cognitive science
KW  - virtual environment
Y1  - 2023
U6  - https://doi.org/10.3389/fpsyg.2023.1119561
SN  - 1664-1078
VL  - 14
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Stübler, Sabine
A1  - Kloft, Charlotte
A1  - Huisinga, Wilhelm
T1  - Cell-level systems biology model to study inflammatory bowel diseases and their treatment options
JF  - CPT: pharmacometrics & systems pharmacology
N2  - To help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment modalities thereof. The model, including key cell types and processes of the mucosal immune response, compiles a large amount of isolated experimental findings from literature into a larger context and allows for simulations of different inflammation scenarios based on the underlying data and assumptions. In the context of a large and diverse virtual IBD population, we characterized the patients based on their phenotype (in contrast to healthy individuals, they developed persistent inflammation after a trigger event) rather than on a priori assumptions on parameter differences to a healthy individual. This allowed to reproduce the enormous diversity of predispositions known to lead to IBD. Analyzing different treatment effects, the model provides insight into characteristics of individual drug therapy. We illustrate for anti-TNF-alpha therapy, how the model can be used (i) to decide for alternative treatments with best prospects in the case of nonresponse, and (ii) to identify promising combination therapies with other available treatment options.
Y1  - 2023
U6  - https://doi.org/10.1002/psp4.12932
SN  - 2163-8306
VL  - 12
IS  - 5
SP  - 690
EP  - 705
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Kaya, Mustafa Yücel
A1  - Dupont-Nivet, Guillaume
A1  - Frieling, Joost
A1  - Fioroni, Chiara
A1  - Rohrmann, Alexander
A1  - Altıner, Sevinç Özkan
A1  - Vardar, Ezgi
A1  - Tanyas, Hakan
A1  - Mamtimin, Mehmut
A1  - Zhaojie, Guo
T1  - The Eurasian epicontinental sea was an important carbon sink during the Palaeocene-Eocene thermal maximum
JF  - Communications earth and environment
N2  - The Palaeocene-Eocene Thermal Maximum (ca. 56 million years ago) offers a primary analogue for future global warming and carbon cycle recovery. Yet, where and how massive carbon emissions were mitigated during this climate warming event remains largely unknown. Here we show that organic carbon burial in the vast epicontinental seaways that extended over Eurasia provided a major carbon sink during the Palaeocene-Eocene Thermal Maximum. We coupled new and existing stratigraphic analyses to a detailed paleogeographic framework and using spatiotemporal interpolation calculated ca. 720–1300 Gt organic carbon excess burial, focused in the eastern parts of the Eurasian epicontinental seaways. A much larger amount (2160–3900 Gt C, and when accounting for the increase in inundated shelf area 7400–10300 Gt C) could have been sequestered in similar environments globally. With the disappearance of most epicontinental seas since the Oligocene-Miocene, an effective negative carbon cycle feedback also disappeared making the modern carbon cycle critically dependent on the slower silicate weathering feedback.
Y1  - 2022
U6  - https://doi.org/10.1038/s43247-022-00451-4
SN  - 2662-4435
VL  - 3
IS  - 1
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - van Soest, Heleen L.
A1  - Aleluia Reis, Lara
A1  - Baptista, Luiz Bernardo
A1  - Bertram, Christoph
A1  - Després, Jacques
A1  - Drouet, Laurent
A1  - den Elzen, Michel
A1  - Fragkos, Panagiotis
A1  - Fricko, Oliver
A1  - Fujimori, Shinichiro
A1  - Grant, Neil
A1  - Harmsen, Mathijs
A1  - Iyer, Gokul
A1  - Keramidas, Kimon
A1  - Köberle, Alexandre C.
A1  - Kriegler, Elmar
A1  - Malik, Aman
A1  - Mittal, Shivika
A1  - Oshiro, Ken
A1  - Riahi, Keywan
A1  - Roelfsema, Mark
A1  - van Ruijven, Bas
A1  - Schaeffer, Roberto
A1  - Silva Herran, Diego
A1  - Tavoni, Massimo
A1  - Ünlü, Gamze
A1  - Vandyck, Toon
A1  - van Vuuren, Detlef P.
T1  - Global roll-out of comprehensive policy measures may aid in bridging emissions gap
JF  - Nature communications
N2  - Closing the emissions gap between Nationally Determined Contributions (NDCs) and the global emissions levels needed to achieve the Paris Agreement’s climate goals will require a comprehensive package of policy measures. National and sectoral policies can help fill the gap, but success stories in one country cannot be automatically replicated in other countries. They need to be adapted to the local context. Here, we develop a new Bridge scenario based on nationally relevant, short-term measures informed by interactions with country experts. These good practice policies are rolled out globally between now and 2030 and combined with carbon pricing thereafter. We implement this scenario with an ensemble of global integrated assessment models. We show that the Bridge scenario closes two-thirds of the emissions gap between NDC and 2 °C scenarios by 2030 and enables a pathway in line with the 2 °C goal when combined with the necessary long-term changes, i.e. more comprehensive pricing measures after 2030. The Bridge scenario leads to a scale-up of renewable energy (reaching 52%–88% of global electricity supply by 2050), electrification of end-uses, efficiency improvements in energy demand sectors, and enhanced afforestation and reforestation. Our analysis suggests that early action via good-practice policies is less costly than a delay in global climate cooperation.
KW  - climate-change mitigation
KW  - climate-change policy
Y1  - 2021
U6  - https://doi.org/10.1038/s41467-021-26595-z
VL  - 12
IS  - 1
PB  - Nature Publishing Group UK
CY  - London
ER  - 
TY  - JOUR
A1  - Ye, Fangyuan
A1  - Zhang, Shuo
A1  - Warby, Jonathan
A1  - Wu, Jiawei
A1  - Gutierrez-Partida, Emilio
A1  - Lang, Felix
A1  - Shah, Sahil
A1  - Saglamkaya, Elifnaz
A1  - Sun, Bowen
A1  - Zu, Fengshuo
A1  - Shoai, Safa
A1  - Wang, Haifeng
A1  - Stiller, Burkhard
A1  - Neher, Dieter
A1  - Zhu, Wei-Hong
A1  - Stolterfoht, Martin
A1  - Wu, Yongzhen
T1  - Overcoming C₆₀-induced interfacial recombination in inverted perovskite solar cells by electron-transporting carborane
JF  - Nature Communications
N2  - Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C₆₀ interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C₆₀ interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23% with a low non-radiative voltage loss of 110 mV, and retain >97% of the initial efficiency after 400 h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells.
Y1  - 2022
U6  - https://doi.org/10.1038/s41467-022-34203-x
SN  - 2041-1723
VL  - 13
IS  - 1
PB  - Springer Nature
CY  - London
ER  - 
TY  - BOOK
ED  - Löw, Martina
ED  - Sayman, Volkan
ED  - Schwerer, Jona
ED  - Wolf, Hannah
T1  - Am Ende der Globalisierung
BT  - über die Refiguration von Räumen
T3  - Re-Figuration von Räumen
N2  - Die Globalisierung ist zur allgegenwärtigen Gewissheit geworden. Doch wie zutreffend ist das Konzept »Globalisierung«, wenn zeitgleich nationale Grenzen gestärkt und transnationale Freihandelszonen ausgeweitet werden, wenn auf unterschiedlichen scales Territorien überwunden und zugleich territoriale Abgrenzungen neu gesetzt werden? Aktuelle Veränderungen als Re-Figuration von Räumen zu verstehen, ermöglicht die Analyse und Diskussion widersprüchlicher, spannungsreicher und konflikthafter räumlicher Prozesse und ihrer alltäglichen Erfahrung. Die interdisziplinären Beiträge des Bandes liefern theoretische und empirische Analysen zu politischen, digitalen und alltäglichen Räumen im Konzept der Re-Figuration.
KW  - Globalisierung
KW  - Raum
KW  - Re-Figuration
KW  - Moderne
KW  - Sicherheit
KW  - Stadt
KW  - Land
KW  - Nationalstaat
KW  - Europa
KW  - Wissen
KW  - Grenze
KW  - Digitale Planung
KW  - Smart City
KW  - Öffentlichkeit
KW  - Medien
KW  - Migration
KW  - Tourismus
KW  - Berlin
KW  - Wandel
KW  - Lebensmittel
KW  - Materialität
KW  - Soziologische Theorie
KW  - Soziologie
KW  - globalization
KW  - space
KW  - modernity
KW  - security
KW  - city
KW  - country
KW  - nation-state
KW  - europe
KW  - knowledge
KW  - border
KW  - digital planning
KW  - public sphere
KW  - media
KW  - tourism
KW  - change
KW  - foods
KW  - materiality
KW  - sociological theory
KW  - sociology
Y1  - 2021
SN  - 978-3-8376-5402-8
SN  - 978-3-8394-5402-2
U6  - https://doi.org/10.14361/9783839454022
VL  - 1
PB  - transcript
CY  - Bielefeld
ER  - 
TY  - JOUR
A1  - Ehrig, Lukas
A1  - Wagner, Ann-Christin
A1  - Wolter, Heike
A1  - Correll, Christoph U.
A1  - Geisel, Olga
A1  - Konigorski, Stefan
T1  - FASDetect as a machine learning-based screening app for FASD in youth with ADHD
JF  - npj Digital Medicine
N2  - Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de.
KW  - Medical research
KW  - Psychiatric disorders
Y1  - 2023
U6  - https://doi.org/10.1038/s41746-023-00864-1
SN  - 2398-6352
VL  - 6
IS  - 1
PB  - Macmillan Publishers Limited
CY  - Basingstoke
ER  - 
TY  - JOUR
A1  - Slosarek, Tamara
A1  - Ibing, Susanne
A1  - Schormair, Barbara
A1  - Heyne, Henrike
A1  - Böttinger, Erwin
A1  - Andlauer, Till
A1  - Schurmann, Claudia
T1  - Implementation and evaluation of personal genetic testing as part of genomics analysis courses in German universities
JF  - BMC Medical Genomics
N2  - Purpose
Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM).

Methods
We compared and evaluated the courses and the students ' perceptions on the course setup using questionnaires.

Results
During the course, students changed their attitudes towards genotyping (HPI: 79% [15 of 19], TUM: 47% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73% [11 of 15], TUM: 72% [18 of 25]) and most students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79% [15 of 19], TUM: 70% [37 of 53]). Students found the personal genotyping component useful (HPI: 89% [17 of 19], TUM: 92% [49 of 53]) and recommended its inclusion in future courses (HPI: 95% [18 of 19], TUM: 98% [52 of 53]).

Conclusion
Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe.
KW  - Genomics education
KW  - Personal genotyping
KW  - Personalized medicine
Y1  - 2023
U6  - https://doi.org/10.1186/s12920-023-01503-0
SN  - 1755-8794
VL  - 16
IS  - 1
PB  - BMC
CY  - London
ER  - 
TY  - CHAP
A1  - Rieskamp, Jonas
A1  - Mirbabaie, Milad
A1  - Hofeditz, Lennart
A1  - Vischedyk, Justin
T1  - Conversational agents and their influence on the well-being of cliniciansclinicians
T2  - ACIS 2023 proceedings
N2  - An increasing number of clinicians (i.e., nurses and physicians) suffer from mental health-related issues like depression and burnout. These, in turn, stress communication, collaboration, and decision- making—areas in which Conversational Agents (CAs) have shown to be useful. Thus, in this work, we followed a mixed-method approach and systematically analysed the literature on factors affecting the well-being of clinicians and CAs’ potential to improve said well-being by relieving support in communication, collaboration, and decision-making in hospitals. In this respect, we are guided by Brigham et al. (2018)’s model of factors influencing well-being. Based on an initial number of 840 articles, we further analysed 52 papers in more detail and identified the influences of CAs’ fields of application on external and individual factors affecting clinicians’ well-being. As our second method, we will conduct interviews with clinicians and experts on CAs to verify and extend these influencing factors.
KW  - conversational agents
KW  - well-being
KW  - mental health
KW  - hospitals
KW  - clinicians
Y1  - 2023
UR  - https://aisel.aisnet.org/acis2023/66
PB  - Australasian Association for Information Systems
CY  - Wellington
ER  - 
TY  - JOUR
A1  - Seroussi, Helene
A1  - Nowicki, Sophie
A1  - Simon, Erika
A1  - Abe-Ouchi, Ayako
A1  - Albrecht, Torsten
A1  - Brondex, Julien
A1  - Cornford, Stephen
A1  - Dumas, Christophe
A1  - Gillet-Chaulet, Fabien
A1  - Goelzer, Heiko
A1  - Golledge, Nicholas R.
A1  - Gregory, Jonathan M.
A1  - Greve, Ralf
A1  - Hoffman, Matthew J.
A1  - Humbert, Angelika
A1  - Huybrechts, Philippe
A1  - Kleiner, Thomas
A1  - Larourl, Eric
A1  - Leguy, Gunter
A1  - Lipscomb, William H.
A1  - Lowry, Daniel
A1  - Mengel, Matthias
A1  - Morlighem, Mathieu
A1  - Pattyn, Frank
A1  - Payne, Anthony J.
A1  - Pollard, David
A1  - Price, Stephen F.
A1  - Quiquet, Aurelien
A1  - Reerink, Thomas J.
A1  - Reese, Ronja
A1  - Rodehacke, Christian B.
A1  - Schlegel, Nicole-Jeanne
A1  - Shepherd, Andrew
A1  - Sun, Sainan
A1  - Sutter, Johannes
A1  - Van Breedam, Jonas
A1  - van de Wal, Roderik S. W.
A1  - Winkelmann, Ricarda
A1  - Zhang, Tong
T1  - initMIP-Antarctica
BT  - an ice sheet model initialization experiment of ISMIP6
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Ice sheet numerical modeling is an important tool to estimate the dynamic contribution of the Antarctic ice sheet to sea level rise over the coming centuries. The influence of initial conditions on ice sheet model simulations, however, is still unclear. To better understand this influence, an initial state intercomparison exercise (initMIP) has been developed to compare, evaluate, and improve initialization procedures and estimate their impact on century-scale simulations. initMlP is the first set of experiments of the Ice Sheet Model Intercomparison Project for CMIP6 (ISMIP6), which is the primary Coupled Model Intercomparison Project Phase 6 (CMIP6) activity focusing on the Greenland and Antarctic ice sheets. Following initMlP-Greenland, initMlP-Antarctica has been designed to explore uncertainties associated with model initialization and spin-up and to evaluate the impact of changes in external forcings. Starting from the state of the Antarctic ice sheet at the end of the initialization procedure, three forward experiments are each run for 100 years: a control run, a run with a surface mass balance anomaly, and a run with a basal melting anomaly beneath floating ice. This study presents the results of initMlP-Antarctica from 25 simulations performed by 16 international modeling groups. The submitted results use different initial conditions and initialization methods, as well as ice flow model parameters and reference external forcings. We find a good agreement among model responses to the surface mass balance anomaly but large variations in responses to the basal melting anomaly. These variations can be attributed to differences in the extent of ice shelves and their upstream tributaries, the numerical treatment of grounding line, and the initial ocean conditions applied, suggesting that ongoing efforts to better represent ice shelves in continental-scale models should continue.
Y1  - 2019
U6  - https://doi.org/10.5194/tc-13-1441-2019
SN  - 1994-0416
SN  - 1994-0424
VL  - 13
IS  - 5
SP  - 1441
EP  - 1471
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Reese, Ronja
A1  - Albrecht, Torsten
A1  - Mengel, Matthias
A1  - Asay-Davis, Xylar
A1  - Winkelmann, Ricarda
T1  - Antarctic sub-shelf melt rates via PICO
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Ocean-induced melting below ice shelves is one of the dominant drivers for mass loss from the Antarctic Ice Sheet at present. An appropriate representation of sub-shelf melt rates is therefore essential for model simulations of marine-based ice sheet evolution. Continental-scale ice sheet models often rely on simple melt-parameterizations, in particular for long-term simulations, when fully coupled ice-ocean interaction becomes computationally too expensive. Such parameterizations can account for the influence of the local depth of the ice-shelf draft or its slope on melting. However, they do not capture the effect of ocean circulation underneath the ice shelf. Here we present the Potsdam Ice-shelf Cavity mOdel (PICO), which simulates the vertical overturning circulation in ice-shelf cavities and thus enables the computation of sub-shelf melt rates consistent with this circulation. PICO is based on an ocean box model that coarsely resolves ice shelf cavities and uses a boundary layer melt formulation. We implement it as a module of the Parallel Ice Sheet Model (PISM) and evaluate its performance under present-day conditions of the Southern Ocean. We identify a set of parameters that yield two-dimensional melt rate fields that qualitatively reproduce the typical pattern of comparably high melting near the grounding line and lower melting or refreezing towards the calving front. PICO captures the wide range of melt rates observed for Antarctic ice shelves, with an average of about 0.1 ma(-1) for cold sub-shelf cavities, for example, underneath Ross or Ronne ice shelves, to 16 ma(-1) for warm cavities such as in the Amundsen Sea region. This makes PICO a computationally feasible and more physical alternative to melt parameterizations purely based on ice draft geometry.
Y1  - 2018
U6  - https://doi.org/10.5194/tc-12-1969-2018
SN  - 1994-0416
SN  - 1994-0424
VL  - 12
IS  - 6
SP  - 1969
EP  - 1985
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Reese, Ronja
A1  - Winkelmann, Ricarda
A1  - Gudmundsson, Gudmundur Hilmar
T1  - Grounding-line flux formula applied as a flux condition in numerical simulations fails for buttressed Antarctic ice streams
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Currently, several large-scale ice-flow models impose a condition on ice flux across grounding lines using an analytically motivated parameterisation of grounding-line flux. It has been suggested that employing this analytical expression alleviates the need for highly resolved computational domains around grounding lines of marine ice sheets. While the analytical flux formula is expected to be accurate in an unbuttressed flow-line setting, its validity has hitherto not been assessed for complex and realistic geometries such as those of the Antarctic Ice Sheet. Here the accuracy of this analytical flux formula is tested against an optimised ice flow model that uses a highly resolved computational mesh around the Antarctic grounding lines. We find that when applied to the Antarctic Ice Sheet the analytical expression provides inaccurate estimates of ice fluxes for almost all grounding lines. Furthermore, in many instances direct application of the analytical formula gives rise to unphysical complex-valued ice fluxes. We conclude that grounding lines of the Antarctic Ice Sheet are, in general, too highly buttressed for the analytical parameterisation to be of practical value for the calculation of grounding-line fluxes.
Y1  - 2018
U6  - https://doi.org/10.5194/tc-12-3229-2018
SN  - 1994-0416
SN  - 1994-0424
VL  - 12
IS  - 10
SP  - 3229
EP  - 3242
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Ciemer, Catrin
A1  - Rehm, Lars
A1  - Kurths, Jürgen
A1  - Donner, Reik Volker
A1  - Winkelmann, Ricarda
A1  - Boers, Niklas
T1  - An early-warning indicator for Amazon droughts exclusively based on tropical Atlantic sea surface temperatures
JF  - Environmental Research Letters
N2  - Droughts in tropical South America have an imminent and severe impact on the Amazon rainforest and affect the livelihoods of millions of people. Extremely dry conditions in Amazonia have been previously linked to sea surface temperature (SST) anomalies in the adjacent tropical oceans. Although the sources and impacts of such droughts have been widely studied, establishing reliable multi-year lead statistical forecasts of their occurrence is still an ongoing challenge. Here, we further investigate the relationship between SST and rainfall anomalies using a complex network approach. We identify four ocean regions which exhibit the strongest overall SST correlations with central Amazon rainfall, including two particularly prominent regions in the northern and southern tropical Atlantic. Based on the time-dependent correlation between SST anomalies in these two regions alone, we establish a new early-warning method for droughts in the central Amazon basin and demonstrate its robustness in hindcasting past major drought events with lead-times up to 18 months.
KW  - complex networks
KW  - droughts
KW  - prediction
KW  - Amazon rainforest
Y1  - 2019
VL  - 15
IS  - 9
PB  - IOP - Institute of Physics Publishing
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Seroussi, Helene
A1  - Nowicki, Sophie
A1  - Payne, Antony J.
A1  - Goelzer, Heiko
A1  - Lipscomb, William H.
A1  - Abe-Ouchi, Ayako
A1  - Agosta, Cecile
A1  - Albrecht, Torsten
A1  - Asay-Davis, Xylar
A1  - Barthel, Alice
A1  - Calov, Reinhard
A1  - Cullather, Richard
A1  - Dumas, Christophe
A1  - Galton-Fenzi, Benjamin K.
A1  - Gladstone, Rupert
A1  - Golledge, Nicholas R.
A1  - Gregory, Jonathan M.
A1  - Greve, Ralf
A1  - Hattermann, Tore
A1  - Hoffman, Matthew J.
A1  - Humbert, Angelika
A1  - Huybrechts, Philippe
A1  - Jourdain, Nicolas C.
A1  - Kleiner, Thomas
A1  - Larour, Eric
A1  - Leguy, Gunter R.
A1  - Lowry, Daniel P.
A1  - Little, Chistopher M.
A1  - Morlighem, Mathieu
A1  - Pattyn, Frank
A1  - Pelle, Tyler
A1  - Price, Stephen F.
A1  - Quiquet, Aurelien
A1  - Reese, Ronja
A1  - Schlegel, Nicole-Jeanne
A1  - Shepherd, Andrew
A1  - Simon, Erika
A1  - Smith, Robin S.
A1  - Straneo, Fiammetta
A1  - Sun, Sainan
A1  - Trusel, Luke D.
A1  - Van Breedam, Jonas
A1  - van de Wal, Roderik S. W.
A1  - Winkelmann, Ricarda
A1  - Zhao, Chen
A1  - Zhang, Tong
A1  - Zwinger, Thomas
T1  - ISMIP6 Antarctica
BT  - a multi-model ensemble of the Antarctic ice sheet evolution over the 21st century
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in response to different climate scenarios and assess the mass loss that would contribute to future sea level rise. However, there is currently no consensus on estimates of the future mass balance of the ice sheet, primarily because of differences in the representation of physical processes, forcings employed and initial states of ice sheet models. This study presents results from ice flow model simulations from 13 international groups focusing on the evolution of the Antarctic ice sheet during the period 2015-2100 as part of the Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). They are forced with outputs from a subset of models from the Coupled Model Intercomparison Project Phase 5 (CMIP5), representative of the spread in climate model results. Simulations of the Antarctic ice sheet contribution to sea level rise in response to increased warming during this period varies between 7:8 and 30.0 cm of sea level equivalent (SLE) under Representative Concentration Pathway (RCP) 8.5 scenario forcing. These numbers are relative to a control experiment with constant climate conditions and should therefore be added to the mass loss contribution under climate conditions similar to present-day conditions over the same period. The simulated evolution of the West Antarctic ice sheet varies widely among models, with an overall mass loss, up to 18.0 cm SLE, in response to changes in oceanic conditions. East Antarctica mass change varies between 6 :1 and 8.3 cm SLE in the simulations, with a significant increase in surface mass balance outweighing the increased ice discharge under most RCP 8.5 scenario forcings. The inclusion of ice shelf collapse, here assumed to be caused by large amounts of liquid water ponding at the surface of ice shelves, yields an additional simulated mass loss of 28mm compared to simulations without ice shelf collapse. The largest sources of uncertainty come from the climate forcing, the ocean-induced melt rates, the calibration of these melt rates based on oceanic conditions taken outside of ice shelf cavities and the ice sheet dynamic response to these oceanic changes. Results under RCP 2.6 scenario based on two CMIP5 climate models show an additional mass loss of 0 and 3 cm of SLE on average compared to simulations done under present-day conditions for the two CMIP5 forcings used and display limited mass gain in East Antarctica.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-3033-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 9
SP  - 3033
EP  - 3070
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Reese, Ronja
A1  - Levermann, Anders
A1  - Albrecht, Torsten
A1  - Seroussi, Helene
A1  - Winkelmann, Ricarda
T1  - The role of history and strength of the oceanic forcing in sea level projections from Antarctica with the Parallel Ice Sheet Model
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Mass loss from the Antarctic Ice Sheet constitutes the largest uncertainty in projections of future sea level rise. Ocean-driven melting underneath the floating ice shelves and subsequent acceleration of the inland ice streams are the major reasons for currently observed mass loss from Antarctica and are expected to become more important in the future. Here we show that for projections of future mass loss from the Antarctic Ice Sheet, it is essential (1) to better constrain the sensitivity of sub-shelf melt rates to ocean warming and (2) to include the historic trajectory of the ice sheet. In particular, we find that while the ice sheet response in simulations using the Parallel Ice Sheet Model is comparable to the median response of models in three Antarctic Ice Sheet Intercomparison projects - initMIP, LARMIP-2 and ISMIP6 - conducted with a range of ice sheet models, the projected 21st century sea level contribution differs significantly depending on these two factors. For the highest emission scenario RCP8.5, this leads to projected ice loss ranging from 1:4 to 4:0 cm of sea level equivalent in simulations in which ISMIP6 ocean forcing drives the PICO ocean box model where parameter tuning leads to a comparably low sub-shelf melt sensitivity and in which no surface forcing is applied. This is opposed to a likely range of 9:1 to 35:8 cm using the exact same initial setup, but emulated from the LARMIP-2 experiments with a higher melt sensitivity, even though both projects use forcing from climate models and melt rates are calibrated with previous oceanographic studies. Furthermore, using two initial states, one with a previous historic simulation from 1850 to 2014 and one starting from a steady state, we show that while differences between the ice sheet configurations in 2015 seem marginal at first sight, the historic simulation increases the susceptibility of the ice sheet to ocean warming, thereby increasing mass loss from 2015 to 2100 by 5% to 50 %. Hindcasting past ice sheet changes with numerical models would thus provide valuable tools to better constrain projections. Our results emphasize that the uncertainty that arises from the forcing is of the same order of magnitude as the ice dynamic response for future sea level projections.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-3097-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 9
SP  - 3097
EP  - 3110
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Zeitz, Maria
A1  - Levermann, Anders
A1  - Winkelmann, Ricarda
T1  - Sensitivity of ice loss to uncertainty in flow law parameters in an idealized one-dimensional geometry
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Acceleration of the flow of ice drives mass losses in both the Antarctic and the Greenland Ice Sheet. The projections of possible future sea-level rise rely on numerical ice-sheet models, which solve the physics of ice flow, melt, and calving. While major advancements have been made by the ice-sheet modeling community in addressing several of the related uncertainties, the flow law, which is at the center of most process-based ice-sheet models, is not in the focus of the current scientific debate. However, recent studies show that the flow law parameters are highly uncertain and might be different from the widely accepted standard values. Here, we use an idealized flow-line setup to investigate how these uncertainties in the flow law translate into uncertainties in flow-driven mass loss. In order to disentangle the effect of future warming on the ice flow from other effects, we perform a suite of experiments with the Parallel Ice Sheet Model (PISM), deliberately excluding changes in the surface mass balance. We find that changes in the flow parameters within the observed range can lead up to a doubling of the flow-driven mass loss within the first centuries of warming, compared to standard parameters. The spread of ice loss due to the uncertainty in flow parameters is on the same order of magnitude as the increase in mass loss due to surface warming. While this study focuses on an idealized flow-line geometry, it is likely that this uncertainty carries over to realistic three-dimensional simulations of Greenland and Antarctica.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-3537-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 10
SP  - 3537
EP  - 3550
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Albrecht, Torsten
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Glacial-cycle simulations of the Antarctic Ice Sheet with the Parallel Ice Sheet Model (PISM)
BT  - Part 1: boundary conditions and climatic forcing
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Simulations of the glacial-interglacial history of the Antarctic Ice Sheet provide insights into dynamic threshold behavior and estimates of the ice sheet's contributions to global sea-level changes for the past, present and future. However, boundary conditions are weakly constrained, in particular at the interface of the ice sheet and the bedrock. Also climatic forcing covering the last glacial cycles is uncertain, as it is based on sparse proxy data. <br /> We use the Parallel Ice Sheet Model (PISM) to investigate the dynamic effects of different choices of input data, e.g., for modern basal heat flux or reconstructions of past changes of sea level and surface temperature. As computational resources are limited, glacial-cycle simulations are performed using a comparably coarse model grid of 16 km and various parameterizations, e.g., for basal sliding, iceberg calving, or for past variations in precipitation and ocean temperatures. In this study we evaluate the model's transient sensitivity to corresponding parameter choices and to different boundary conditions over the last two glacial cycles and provide estimates of involved uncertainties. We also discuss isolated and combined effects of climate and sea-level forcing. Hence, this study serves as a "cookbook" for the growing community of PISM users and paleo-ice sheet modelers in general. <br /> For each of the different model uncertainties with regard to climatic forcing, ice and Earth dynamics, and basal processes, we select one representative model parameter that captures relevant uncertainties and motivates corresponding parameter ranges that bound the observed ice volume at present. The four selected parameters are systematically varied in a parameter ensemble analysis, which is described in a companion paper.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-599-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 2
SP  - 599
EP  - 632
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Kreuzer, Moritz
A1  - Reese, Ronja
A1  - Huiskamp, Willem Nicholas
A1  - Petri, Stefan
A1  - Albrecht, Torsten
A1  - Feulner, Georg
A1  - Winkelmann, Ricarda
T1  - Coupling framework (1.0) for the PISM (1.1.4) ice sheet model and the MOMS (5.1.0) ocean model via the PICO ice shelf cavity model in an Antarctic domain
JF  - Geoscientific model development : an interactive open access journal of the European Geosciences Union
N2  - The past and future evolution of the Antarctic Ice Sheet is largely controlled by interactions between the ocean and floating ice shelves. To investigate these interactions, coupled ocean and ice sheet model configurations are required. Previous modelling studies have mostly relied on high-resolution configurations, limiting these studies to individual glaciers or regions over short timescales of decades to a few centuries. We present a framework to couple the dynamic ice sheet model PISM (Parallel Ice Sheet Model) with the global ocean general circulation model MOM5 (Modular Ocean Model) via the ice shelf cavity model PICO (Pots-dam Ice-shelf Cavity mOdel). As ice shelf cavities are not resolved by MOM5 but are parameterized with the PICO box model, the framework allows the ice sheet and ocean components to be run at resolutions of 16 km and 3 degrees respectively. This approach makes the coupled configuration a useful tool for the analysis of interactions between the Antarctic Ice Sheet and the global ocean over time spans of the order of centuries to millennia. In this study, we describe the technical implementation of this coupling framework: sub-shelf melting in the ice sheet component is calculated by PICO from modelled ocean temperatures and salinities at the depth of the continental shelf, and, vice versa, the resulting mass and energy fluxes from melting at the ice-ocean interface are transferred to the ocean component. Mass and energy fluxes are shown to be conserved to machine precision across the considered component domains. The implementation is computationally efficient as it introduces only minimal overhead. Furthermore, the coupled model is evaluated in a 4000 year simulation under constant present-day climate forcing and is found to be stable with respect to the ocean and ice sheet spin-up states. The framework deals with heterogeneous spatial grid geometries, varying grid resolutions, and timescales between the ice and ocean component in a generic way; thus, it can be adopted to a wide range of model set-ups.
Y1  - 2021
U6  - https://doi.org/10.5194/gmd-14-3697-2021
SN  - 1991-959X
SN  - 1991-9603
VL  - 14
IS  - 6
SP  - 3697
EP  - 3714
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Zeitz, Maria
A1  - Haacker, Jan M.
A1  - Donges, Jonathan
A1  - Albrecht, Torsten
A1  - Winkelmann, Ricarda
T1  - Dynamic regimes of the Greenland Ice Sheet emerging from interacting melt-elevation and glacial isostatic adjustment feedbacks
JF  - Earth system dynamics
N2  - The stability of the Greenland Ice Sheet under global warming is governed by a number of dynamic processes and interacting feedback mechanisms in the ice sheet, atmosphere and solid Earth. 
Here we study the long-term effects due to the interplay of the competing melt-elevation and glacial isostatic adjustment (GIA) feedbacks for different temperature step forcing experiments with a coupled ice-sheet and solid-Earth model. 
Our model results show that for warming levels above 2 degrees C, Greenland could become essentially ice-free within several millennia, mainly as a result of surface melting and acceleration of ice flow. These ice losses are mitigated, however, in some cases with strong GIA feedback even promoting an incomplete recovery of the Greenland ice volume. We further explore the full-factorial parameter space determining the relative strengths of the two feedbacks: our findings suggest distinct dynamic regimes of the Greenland Ice Sheets on the route to destabilization under global warming - from incomplete recovery, via quasi-periodic oscillations in ice volume to ice-sheet collapse. 
In the incomplete recovery regime, the initial ice loss due to warming is essentially reversed within 50 000 years, and the ice volume stabilizes at 61 %-93 % of the present-day volume. For certain combinations of temperature increase, atmospheric lapse rate and mantle viscosity, the interaction of the GIA feedback and the melt-elevation feedback leads to self-sustained, long-term oscillations in ice-sheet volume with oscillation periods between 74 000 and over 300 000 years and oscillation amplitudes between 15 %-70 % of present-day ice volume. 
This oscillatory regime reveals a possible mode of internal climatic variability in the Earth system on timescales on the order of 100 000 years that may be excited by or synchronized with orbital forcing or interact with glacial cycles and other slow modes of variability. Our findings are not meant as scenario-based near-term projections of ice losses but rather providing insight into of the feedback loops governing the "deep future" and, thus, long-term resilience of the Greenland Ice Sheet.
Y1  - 2022
U6  - https://doi.org/10.5194/esd-13-1077-2022
SN  - 2190-4979
SN  - 2190-4987
VL  - 13
IS  - 3
SP  - 1077
EP  - 1096
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Albrecht, Torsten
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Glacial-cycle simulations of the Antarctic Ice Sheet with the Parallel Ice Sheet Model (PISM)
BT  - part 2: parameter ensemble analysis
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - The Parallel Ice Sheet Model (PISM) is applied to the Antarctic Ice Sheet over the last two glacial cycles (approximate to 210 000 years) with a resolution of 16 km. An ensemble of 256 model runs is analyzed in which four relevant model parameters have been systematically varied using full-factorial parameter sampling. Parameters and plausible parameter ranges have been identified in a companion paper (Albrecht et al., 2020) and are associated with ice dynamics, climatic forcing, basal sliding and bed deformation and represent distinct classes of model uncertainties. The model is scored against both modern and geologic data, including reconstructed grounding-line locations, elevation-age data, ice thickness, surface velocities and uplift rates. An aggregated score is computed for each ensemble member that measures the overall model-data misfit, including measurement uncertainty in terms of a Gaussian error model (Briggs and Tarasov, 2013). The statistical method used to analyze the ensemble simulation results follows closely the simple averaging method described in Pollard et al. (2016). 
This analysis reveals clusters of best-fit parameter combinations, and hence a likely range of relevant model and boundary parameters, rather than individual best-fit parameters. The ensemble of reconstructed histories of Antarctic Ice Sheet volumes provides a score-weighted likely range of sea-level contributions since the Last Glacial Maximum (LGM) of 9.4 +/- 4.1m (or 6.5 +/- 2.0 x 10(6) km(3)), which is at the upper range of most previous studies. The last deglaciation occurs in all ensemble simulations after around 12 000 years before present and hence after the meltwater pulse 1A (MWP1a). Our ensemble analysis also provides an estimate of parametric uncertainty bounds for the present-day state that can be used for PISM projections of future sea-level contributions from the Antarctic Ice Sheet.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-633-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 2
SP  - 633
EP  - 656
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Schlemm, Tanja
A1  - Feldmann, Johannes
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Stabilizing effect of melange buttressing on the marine ice-cliff instability of the West Antarctic Ice Sheet
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Owing to global warming and particularly high regional ocean warming, both Thwaites and Pine Island Glaciers in the Amundsen region of the Antarctic Ice Sheet could lose their buttressing ice shelves over time. We analyse the possible consequences using the parallel ice sheet model (PISM), applying a simple cliff-calving parameterization and an ice melange-buttressing model. We find that the instantaneous loss of ice-shelf buttressing, due to enforced ice-shelf melting, initiates grounding-line retreat and triggers marine ice sheet instability (MISI). As a consequence, the grounding line progresses into the interior of the West Antarctic Ice Sheet and leads to a sea level contribution of 0.6 m within 100 a. By subjecting the exposed ice cliffs to cliff calving using our simplified parameterization, we also analyse marine ice cliff instability (MICI). In our simulations it can double or even triple the sea level contribution depending on the only loosely constrained parameter that determines the maximum cliff-calving rate. The speed of MICI depends on this upper bound of the calving rate, which is given by the ice melange buttressing the glacier. However, stabilization of MICI may occur for geometric reasons. Because the embayment geometry changes as MICI advances into the interior of the ice sheet, the upper bound on calving rates is reduced and the progress of MICI is slowed down. Although we cannot claim that our simulations bear relevant quantitative estimates of the effect of ice-melange buttressing on MICI, the mechanism has the potential to stop the instability. Further research is needed to evaluate its role for the past and future evolution of the Antarctic Ice Sheet.
Y1  - 2022
U6  - https://doi.org/10.5194/tc-16-1979-2022
SN  - 1994-0416
SN  - 1994-0424
VL  - 16
IS  - 5
SP  - 1979
EP  - 1996
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Feldmann, Johannes
A1  - Reese, Ronja
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Shear-margin melting causes stronger transient ice discharge than ice-stream melting in idealized simulations
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Basal ice-shelf melting is the key driver of Antarctica's increasing sea-level contribution. In diminishing the buttressing force of the ice shelves that fringe the ice sheet, the melting increases the ice discharge into the ocean.
Here we contrast the influence of basal melting in two different ice-shelf regions on the time-dependent response of an isothermal, inherently buttressed ice-sheet-shelf system. In the idealized numerical simulations, the basal-melt perturbations are applied close to the grounding line in the ice-shelf's (1) ice-stream region, where the ice shelf is fed by the fastest ice masses that stream through the upstream bed trough and (2) shear margins, where the ice flow is slower.
The results show that melting below one or both of the shear margins can cause a decadal to centennial increase in ice discharge that is more than twice as large compared to a similar perturbation in the ice-stream region. We attribute this to the fact that melt-induced ice-shelf thinning in the central grounding-line region is attenuated very effectively by the fast flow of the central ice stream. In contrast, the much slower ice dynamics in the lateral shear margins of the ice shelf facilitate sustained ice-shelf thinning and thereby foster buttressing reduction.
Regardless of the melt location, a higher melt concentration toward the grounding line generally goes along with a stronger response. Our results highlight the vulnerability of outlet glaciers to basal melting in stagnant, buttressing-relevant ice-shelf regions, a mechanism that may gain importance under future global warming.
Y1  - 2022
U6  - https://doi.org/10.5194/tc-16-1927-2022
SN  - 1994-0416
SN  - 1994-0424
VL  - 16
IS  - 5
SP  - 1927
EP  - 1940
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Wunderling, Nico
A1  - Willeit, Matteo
A1  - Donges, Jonathan
A1  - Winkelmann, Ricarda
T1  - Global warming due to loss of large ice masses and Arctic summer sea ice
JF  - Nature Communications
N2  - Several large-scale cryosphere elements such as the Arctic summer sea ice, the mountain glaciers, the Greenland and West Antarctic Ice Sheet have changed substantially during the last century due to anthropogenic global warming. However, the impacts of their possible future disintegration on global mean temperature (GMT) and climate feedbacks have not yet been comprehensively evaluated. Here, we quantify this response using an Earth system model of intermediate complexity. Overall, we find a median additional global warming of 0.43 degrees C (interquartile range: 0.39-0.46 degrees C) at a CO2 concentration of 400 ppm. Most of this response (55%) is caused by albedo changes, but lapse rate together with water vapour (30%) and cloud feedbacks (15%) also contribute significantly. While a decay of the ice sheets would occur on centennial to millennial time scales, the Arctic might become ice-free during summer within the 21st century. Our findings imply an additional increase of the GMT on intermediate to long time scales. The disintegration of cryosphere elements such as the Arctic summer sea ice, mountain glaciers, Greenland and West Antarctica is associated with temperature and radiative feedbacks. In this work, the authors quantify these feedbacks and find an additional global warming of 0.43 degrees C.
Y1  - 2020
U6  - https://doi.org/10.1038/s41467-020-18934-3
SN  - 2041-1723
VL  - 11
IS  - 1
PB  - Nature Publishing Group
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Zeitz, Maria
A1  - Reese, Ronja
A1  - Beckmann, Johanna
A1  - Krebs-Kanzow, Uta
A1  - Winkelmann, Ricarda
T1  - Impact of the melt-albedo feedback on the future evolution of the Greenland Ice Sheet with PISM-dEBM-simple
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Surface melting of the Greenland Ice Sheet contributes a large amount to current and future sea level rise. Increased surface melt may lower the reflectivity of the ice sheet surface and thereby increase melt rates: the so-called melt-albedo feedback describes this self-sustaining increase in surface melting. In order to test the effect of the melt-albedo feedback in a prognostic ice sheet model, we implement dEBM-simple, a simplified version of the diurnal Energy Balance Model dEBM, in the Parallel Ice Sheet Model (PISM). The implementation includes a simple representation of the melt-albedo feedback and can thereby replace the positive-degree-day melt scheme. Using PISM-dEBM-simple, we find that this feedback increases ice loss through surface warming by 60 % until 2300 for the high-emission scenario RCP8.5 when compared to a scenario in which the albedo remains constant at its present-day values. With an increase of 90 % compared to a fixed-albedo scenario, the effect is more pronounced for lower surface warming under RCP2.6. Furthermore, assuming an immediate darkening of the ice surface over all summer months, we estimate an upper bound for this effect to be 70 % in the RCP8.5 scenario and a more than 4-fold increase under RCP2.6. With dEBM-simple implemented in PISM, we find that the melt-albedo feedback is an essential contributor to mass loss in dynamic simulations of the Greenland Ice Sheet under future warming.
Y1  - 2021
U6  - https://doi.org/10.5194/tc-15-5739-2021
SN  - 1994-0416
SN  - 1994-0424
VL  - 15
IS  - 12
SP  - 5739
EP  - 5764
PB  - Copernicus
CY  - Katlenburg-Lindau
ER  - 
TY  - JOUR
A1  - Klose, Ann Kristin
A1  - Wunderling, Nico
A1  - Winkelmann, Ricarda
A1  - Donges, Jonathan
T1  - What do we mean, 'tipping cascade'?
JF  - Environmental research letters : ERL
N2  - Based on suggested interactions of potential tipping elements in the Earth's climate and in ecological systems, tipping cascades as possible dynamics are increasingly discussed and studied. The activation of such tipping cascades would impose a considerable risk for human societies and biosphere integrity. However, there are ambiguities in the description of tipping cascades within the literature so far. Here we illustrate how different patterns of multiple tipping dynamics emerge from a very simple coupling of two previously studied idealized tipping elements. In particular, we distinguish between a two phase cascade, a domino cascade and a joint cascade. A mitigation of an unfolding two phase cascade may be possible and common early warning indicators are sensitive to upcoming critical transitions to a certain degree. In contrast, a domino cascade may hardly be stopped once initiated and critical slowing down-based indicators fail to indicate tipping of the following element. These different potentials for intervention and anticipation across the distinct patterns of multiple tipping dynamics should be seen as a call to be more precise in future analyses of cascading dynamics arising from tipping element interactions in the Earth system.
KW  - tipping cascade
KW  - domino effect
KW  - tipping interactions
KW  - cascading regime
KW  - shifts
KW  - early warning indicators
Y1  - 2021
U6  - https://doi.org/10.1088/1748-9326/ac3955
SN  - 1748-9326
VL  - 16
IS  - 12
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Tiberius, Victor
A1  - Weyland, Michael
T1  - Identifying constituent elements of entrepreneurship curricula
BT  - a systematic literature review
JF  - Administrative sciences
N2  - Entrepreneurship education research has a strong “output” focus on impact studies but pays much less attention to the “inside” or process perspective of the way entrepreneurship education occurs. In particular, the scattered previous entrepreneurship curriculum research has not managed to provide a current and comprehensive overview of the curricular elements that constitute entrepreneurship education. To overcome this shortcoming, we aim to identify the teaching objectives, teaching contents, teaching methods, and assessment methods discussed in entrepreneurship curriculum research. To this end, we conducted a systematic literature review on the four entrepreneurship curriculum dimensions and collected all mentioned curriculum items. We used a two-stage coding procedure to find the genuinely entrepreneurship-specific items. Among numerous items (also from business management and other subjects), we found 26 objectives, 34 contents, 11 teaching methods, and 7 assessment methods that were entrepreneurship-specific. Most of these items were addressed by only a few scholarly papers.
KW  - assessment methods
KW  - curriculum
KW  - entrepreneurship education
KW  - teaching contents
KW  - teaching methods
KW  - teaching objectives
Y1  - 2023
U6  - https://doi.org/10.3390/admsci14010001
SN  - 2076-3387
VL  - 14
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Romero Barbosa, Luís
A1  - Coelho, Victor Hugo R.
A1  - Scheiffele, Lena
A1  - Baroni, Gabriele
A1  - Ramos Filho, Geraldo M.
A1  - Montenegro, Suzana M. G. L.
A1  - Das Neves Almeida, Cristiano
A1  - Oswald, Sascha
T1  - Dynamic groundwater recharge simulations based on cosmic-ray neutron sensing in a tropical wet experimental basin
JF  - Vadose zone journal : VZJ : advancing critical zone science
N2  - Although cosmic-ray neutron sensing (CRNS) is probably the most promising noninvasive proximal soil moisture measurement technique at the field scale, its application for hydrological simulations remains underexplored in the literature so far. This study assessed the use of CRNS to inversely calibrate soil hydraulic parameters at the intermediate field scale to simulate the groundwater recharge rates at a daily timescale. The study was conducted for two contrasting hydrological years at the Guaraira experimental basin, Brazil, a 5.84-km(2), a tropical wet and rather flat landscape covered by secondary Atlantic forest. As a consequence of the low altitude and proximity to the equator low neutron count rates could be expected, reducing the precision of CRNS while constituting unexplored and challenging conditions for CRNS applications. Inverse calibration for groundwater recharge rates was used based on CRNS or point-scale soil moisture data. The CRNS-derived retention curve and saturated hydraulic conductivity were consistent with the literature and locally performed slug tests. Simulated groundwater recharge rates ranged from 60 to 470 mm yr(-1), corresponding to 5 and 29% of rainfall, and correlated well with estimates based on water table fluctuations. In contrast, the estimated results based on inversive point-scale datasets were not in alignment with measured water table fluctuations. The better performance of CRNS-based estimations of field-scale hydrological variables, especially groundwater recharge, demonstrated its clear advantages over traditional invasive point-scale techniques. Finally, the study proved the ability of CRNS as practicable in low altitude, tropical wet areas, thus encouraging its adoption for water resources monitoring and management.
Y1  - 2021
U6  - https://doi.org/10.1002/vzj2.20145
SN  - 1539-1663
VL  - 20
IS  - 4
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Durand, Gael
A1  - van den Broeke, Michiel R.
A1  - Le Cozannet, Goneri
A1  - Edwards, Tamsin L.
A1  - Holland, Paul R.
A1  - Jourdain, Nicolas C.
A1  - Marzeion, Ben
A1  - Mottram, Ruth
A1  - Nicholls, Robert J.
A1  - Pattyn, Frank
A1  - Paul, Frank
A1  - Slangen, Aimee B. A.
A1  - Winkelmann, Ricarda
A1  - Burgard, Clara
A1  - van Calcar, Caroline J.
A1  - Barre, Jean-Baptiste
A1  - Bataille, Amelie
A1  - Chapuis, Anne
T1  - Sea-Level rise: from global perspectives to local services
JF  - Frontiers in Marine Science
N2  - Coastal areas are highly diverse, ecologically rich, regions of key socio-economic activity, and are particularly sensitive to sea-level change. Over most of the 20th century, global mean sea level has risen mainly due to warming and subsequent expansion of the upper ocean layers as well as the melting of glaciers and ice caps. Over the last three decades, increased mass loss of the Greenland and Antarctic ice sheets has also started to contribute significantly to contemporary sea-level rise. The future mass loss of the two ice sheets, which combined represent a sea-level rise potential of similar to 65 m, constitutes the main source of uncertainty in long-term (centennial to millennial) sea-level rise projections. Improved knowledge of the magnitude and rate of future sea-level change is therefore of utmost importance. Moreover, sea level does not change uniformly across the globe and can differ greatly at both regional and local scales. The most appropriate and feasible sea level mitigation and adaptation measures in coastal regions strongly depend on local land use and associated risk aversion. Here, we advocate that addressing the problem of future sea-level rise and its impacts requires (i) bringing together a transdisciplinary scientific community, from climate and cryospheric scientists to coastal impact specialists, and (ii) interacting closely and iteratively with users and local stakeholders to co-design and co-build coastal climate services, including addressing the high-end risks.
KW  - sea-level rise
KW  - Antarctic
KW  - Greenland
KW  - glaciers
KW  - local impact
Y1  - 2022
U6  - https://doi.org/10.3389/fmars.2021.709595
SN  - 2296-7745
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - BOOK
A1  - Leubner, Martin
A1  - Saupe, Anja
T1  - Differenzierung im Literaturunterricht
BT  - ein Leitfaden und Aufgabenbeispiele
N2  - Der Band stellt ein Modell für einen differenzierenden Literaturunterricht vor, der individuelle Förderung für unterschiedliche Bereiche von Heterogenität ermöglicht.

Eine ergiebige Differenzierung nutzt die Aspekte Ziele, Themen und Methoden des Unterrichts sowie Lenkung und Aufgabenformat. Diese Aspekte werden mit Blick auf die einzelnen Phasen des Unterrichts präzisiert. Dabei werden Leistungsunterschiede, sprachliche, kulturelle und soziale sowie individuelle Voraussetzungen der einzelnen Schüler:innen deutlicher adressiert.

Einzelne exemplarische Aufgabensets mit ausführlicher Erläuterung dienen der Veranschaulichung des Modells. Zudem werden Unterrichtseinheiten vorgestellt, die systematisch Möglichkeiten der Differenzierung nutzen.
Y1  - 2023
UR  - https://www.wbv.de/shop/Differenzierung-im-Literaturunterricht-I73538
SN  - 978-3-76397-352-1
SN  - 978-3-76397-353-8
U6  - https://doi.org/10.3278/9783763973538
PB  - wbv
CY  - Bielefeld
ER  - 
TY  - BOOK
A1  - Franz, Norbert P.
T1  - Der russische Krimi
BT  - Buch und Film ; Von Škljarevskij bis Akunin
N2  - Die erste umfassende Darstellung des Kriminalgenres in Russland. Sie geht auf Bücher und Filme ein und berücksichtigt die Debatten der Literaturkritik, da sich die Kulturpolitik während der sowjetischen Jahrzehnte schwer damit tat, dem Kriminalgenre überhaupt ein Existenzrecht zubilligen. Sympathie für die Miliz zu erzeugen wurde schließlich offizieller Zweck dieses politisch zu einer Nischenexistenz gedrängten Genres. Entsprechend liegt ein Akzent der Studie auf der Ideologie, besonders bei der Darstellung der Helden und ihrer Gegner und der Lebenswelt, die die Leser als ihre wiedererkennen sollten. Dabei erfahren sie eine Menge über die Gesellschaft, vor allem über deren sonst eher verschwiegene Schattenseiten. 
Nicht zuletzt wegen der langen Entbehrung spannender Texte wurde der Krimi nach dem Ende des Sozialismus zu dem Bestsellergenre schlechthin. Am Beispiel des Frauenkrimis (Marinina und Nachfolgerinnen) und des postmodernen Krimis (Akunin) wird die postsowjetische Entwicklung bis in die 2010er Jahre gezeigt.
N2  - Первое объемное исследование детективного жанра в России. В нем анализируются книги и фильмы, учитываются дебаты в литературной критике, поскольку культурная политика в советские десятилетия не давала криминальному жанру полные права на существование. Создание положительного и привлекательного образа милиции стало в итоге официальной задачей этого жанра, который политически был вынужден существовать в определенной нише. Соответственно в исследовании значительное внимание уделяется идеологии, особенно в изображении героев и их противников, а также их жизненной среды, с которой должен был познакомиться читатель. В процессе чтения он узнает много нового об обществе, особенно о его темной стороне, которую принято было по идеологическим причинам замалчивать. 
В годы горбачевской перестройки и гласности детективный роман постепенно стал жанром бестселлера par excellence. Постсоветское развитие вплоть до 2010-х годов показано на примере женского детектива (Маринина и ее преемницы) и постмодернистского криминального романа (Акунин).
N2  - Der russische Krimi presents the first comprehensive account of crime fiction in Russia. It offers detailed discussions of books and movies and also of the broader critical literary debates, as cultural policy during the Soviet decades would not easily grant the crime genre any right to exist. Instead, generating sympathy for the security apparatus eventually became the official purpose of this genre, which was politically relegated to a niche existence. Accordingly, the study places particular emphasis on ideology, especially in the portrayal of the heroes and their opponents and a fictional reality that the reader should nonetheless recognize as his own. In this process, he learns a lot about the darker sides of society that are otherwise mostly kept secret. Not least because of the long-time scarcity of exciting texts, after the end of socialism crime fiction became the bestseller genre par excellence. These post-Soviet developments up to the 2010s are shown using the example of the women's crime novel (Marinina and her successors) and the postmodern crime novel (Akunin).
KW  - Russische Kulturgeschichte
KW  - Kriminalliteratur
KW  - Russische Popularkultur
KW  - Sozialistischer Realismus
KW  - Frauenkrimi
KW  - postmoderner Krimi
KW  - Kriminalfilm
KW  - Aleksandr Škljarevskij (1837-1883)
KW  - Arkadij Adamov (1920-1991)
KW  - Arkadij Vajner (1931-2005)
KW  - Georgij Vajner (1938-2009)
KW  - Aleksandra Marinina (*1957)
KW  - Boris Akunin (*1956)
KW  - история русской культуры
KW  - русская популярная культура
KW  - детективный жанр
KW  - социалистический реализм
KW  - женский детектив
KW  - постмодернистский детектив
KW  - Russian cultural history
KW  - Crime fiction
KW  - Russian popular culture
KW  - Socialist realism
KW  - women’s crime fiction
KW  - postmodern crime fiction
Y1  - 2024
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-615591
SN  - 978-3-86956-549-1
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Moreno-Romero, Jordi
A1  - Probst, Aline V.
A1  - Trindade, Inês
A1  - Kalyanikrishna, 
A1  - Engelhorn, Julia
A1  - Farrona, Sara
T1  - Looking At the Past and Heading to the Future
BT  - Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany
T2  - Frontiers in Plant Science
N2  - In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how chromatin organization controls gene expression, development, and plant responses to the environment. New evidence showing how epigenetic states are set, perpetuated, and inherited were presented, and novel data related to the three-dimensional organization of chromatin within the nucleus were discussed. At the level of the nucleosome, its composition by different histone variants and their specialized histone deposition complexes were addressed as well as the mechanisms involved in histone post-translational modifications and their role in gene expression. The keynote lecture on plant DNA methylation by Julie Law (SALK Institute) and the tribute session to Lars Hennig, honoring the memory of one of the founders of the EWPC who contributed to promote the plant chromatin and epigenetic field in Europe, added a very special note to this gathering. In this perspective article we summarize some of the most outstanding data and advances on plant chromatin research presented at this workshop.
KW  - EWPC2019
KW  - chromatin
KW  - epigenetics
KW  - transcription
KW  - nucleus
Y1  - 2020
U6  - https://doi.org/10.3389/fpls.2019.01795
SN  - 1664-462X
VL  - 10
IS  - 1795
SP  - 1
EP  - 12
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - GEN
A1  - Grohmann, Nils-Hendrik
T1  - How to avoid politicised monitoring?
BT  - treaty-design suggestions for a business and human rights framework convention
T2  - Völkerrechtsblog : Der Blog des Arbeitskreis junger Völkerrechtswissenschaftler*innen
Y1  - 2022
UR  - https://voelkerrechtsblog.org/de/how-to-avoid-politicised-monitoring/
U6  - https://doi.org/10.17176/20220623-153108-0
SN  - 2510-2567
PB  - M. Riegner c/o Humboldt-Univ
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pang, Peter Tsun Ho
A1  - Dietrich, Tim
A1  - Tews, Ingo
A1  - Van Den Broeck, Chris
T1  - Parameter estimation for strong phase transitions in supranuclear matter using gravitational-wave astronomy
JF  - Physical review research
N2  - At supranuclear densities, explored in the core of neutron stars, a strong phase transition from hadronic matter to more exotic forms of matter might be present. To test this hypothesis, binary neutron-star mergers offer a unique possibility to probe matter at densities that we cannot create in any existing terrestrial experiment. In this work, we show that, if present, strong phase transitions can have a measurable imprint on the binary neutron-star coalescence and the emitted gravitational-wave signal. We construct a new parametrization of the supranuclear equation of state that allows us to test for the existence of a strong phase transition and extract its characteristic properties purely from the gravitational-wave signal of the inspiraling neutron stars. We test our approach using a Bayesian inference study simulating 600 signals with three different equations of state and find that for current gravitational-wave detector networks already 12 events might be sufficient to verify the presence of a strong phase transition. Finally, we use our methodology to analyze GW170817 and GW190425 but do not find any indication that a strong phase transition is present at densities probed during the inspiral.
Y1  - 2020
U6  - https://doi.org/10.1103/PhysRevResearch.2.033514
SN  - 2643-1564
VL  - 2
IS  - 3
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Bosch, Sina
A1  - De Cesare, Ilaria
A1  - Demske, Ulrike
A1  - Felser, Claudia
T1  - Word-order variation and coherence in German infinitival complementation
JF  - The journal of comparative Germanic linguistics
N2  - This study provides a synthesis of corpus-based and experimental investigations of word-order preferences in German infinitival complementation. We carried out a systematic analysis of present-day German corpora to establish frequency distributions of different word-order options: extraposition, intraposition, and 'third construction'. We then examined, firstly, whether and to what extent corpus frequencies and processing economy constraints can predict the acceptability of these three word-order variants, and whether subject raising and subject control verbs form clearly distinguishable subclasses of infinitive-embedding verbs in terms of their word-order behaviour. Secondly, our study looks into the issue of coherence by comparing acceptability ratings for monoclausal coherent and biclausal incoherent construals of intraposed infinitives, and by examining whether a biclausal incoherent analysis gives rise to local and/or global processing difficulty. Taken together, our results revealed that (i) whilst the extraposition pattern consistently wins out over all other word-order variants for control verbs, neither frequency nor processing-based approaches to word-order variation can account for the acceptability of low-frequency variants, (ii) there is considerable verb-specific variation regarding word-order preferences both between and within the two sets of raising and control verbs under investigation, and (iii) although monoclausal coherent intraposition is rated above biclausal incoherent intraposition, the latter is not any more difficult to process than the former. Our findings indicate that frequency of occurrence and processing-related constraints interact with idiosyncratic lexical properties of individual verbs in determining German speakers' structural preferences.
KW  - Syntactic variation
KW  - German
KW  - Infinitives
KW  - Corpus linguistics
KW  - Acceptability judgements
KW  - Self-paced reading
Y1  - 2023
U6  - https://doi.org/10.1007/s10828-023-09140-8
SN  - 1572-8552
VL  - 26
IS  - 1
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Bulla, Mattia
A1  - Coughlin, Michael W.
A1  - Dhawan, Suhail
A1  - Dietrich, Tim
T1  - Multi-messenger constraints on the Hubble constant through combination of gravitational waves, gamma-ray bursts and kilonovae from neutron star mergers
JF  - Universe : open access journal
N2  - The simultaneous detection of gravitational waves and light from the binary neutron star merger GW170817 led to independent measurements of distance and redshift, providing a direct estimate of the Hubble constant H-0 that does not rely on a cosmic distance ladder, nor assumes a specific cosmological model. 
By using gravitational waves as "standard sirens", this approach holds promise to arbitrate the existing tension between the H-0 value inferred from the cosmic microwave background and those obtained from local measurements.
However, the known degeneracy in the gravitational-wave analysis between distance and inclination of the source led to a H-0 value from GW170817 that was not precise enough to resolve the existing tension. 
In this review, we summarize recent works exploiting the viewing-angle dependence of the electromagnetic signal, namely the associated short gamma-ray burst and kilonova, to constrain the system inclination and improve on H-0. 
We outline the key ingredients of the different methods, summarize the results obtained in the aftermath of GW170817 and discuss the possible systematics introduced by each of these methods.
KW  - gravitational waves
KW  - stars: neutron
KW  - stars: binaries
KW  - cosmology: cosmological parameters
KW  - cosmology: distance scale
KW  - cosmology: cosmic background radiation
Y1  - 2022
U6  - https://doi.org/10.3390/universe8050289
SN  - 2218-1997
VL  - 8
IS  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Tiberius, Victor
A1  - Weyland, Michael
T1  - Improving curricula for higher entrepreneurship education
BT  - an international real-time Delphi
JF  - Education sciences
N2  - Existing curricula for entrepreneurship education do not necessarily represent the best way of teaching. How could entrepreneurship curricula be improved? To answer this question, we aim to identify and rank desirable teaching objectives, teaching contents, teaching methods, and assessment methods for higher entrepreneurship education. To this end, we employ an international real-time Delphi study with an expert panel consisting of entrepreneurship education instructors and researchers. The study reveals 17 favorable objectives, 17 items of content, 25 teaching methods, and 15 assessment methods, which are ranked according to their desirability and the group consensus. We contribute to entrepreneurship curriculum research by adding a normative perspective.
KW  - curriculum design
KW  - Delphi study
KW  - entrepreneurship education
Y1  - 2024
U6  - https://doi.org/10.3390/educsci14020130
SN  - 2227-7102
VL  - 14
IS  - 2
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Lehmann, Nico
A1  - Kuhn, Yves-Alain
A1  - Keller, Martin
A1  - Aye, Norman
A1  - Herold, Fabian
A1  - Draganski, Bogdan
A1  - Taube, Wolfgang
A1  - Taubert, Marco
T1  - Brain activation during active balancing and its behavioral relevance in younger and older adults
BT  - a functional near-infrared spectroscopy (fNIRS) study
JF  - Frontiers in Aging Neuroscience
N2  - Age-related deterioration of balance control is widely regarded as an important phenomenon influencing quality of life and longevity, such that a more comprehensive understanding of the neural mechanisms underlying this process is warranted.

Specifically, previous studies have reported that older adults typically show higher neural activity during balancing as compared to younger counterparts, but the implications of this finding on balance performance remain largely unclear. 
Using functional near-infrared spectroscopy (fNIRS), differences in the cortical control of balance between healthy younger (n = 27) and older (n = 35) adults were explored. 

More specifically, the association between cortical functional activity and balance performance across and within age groups was investigated. To this end, we measured hemodynamic responses (i.e., changes in oxygenated and deoxygenated hemoglobin) while participants balanced on an unstable device. 
As criterion variables for brain-behavior-correlations, we also assessed postural sway while standing on a free-swinging platform and while balancing on wobble boards with different levels of difficulty. 

We found that older compared to younger participants had higher activity in prefrontal and lower activity in postcentral regions. 
Subsequent robust regression analyses revealed that lower prefrontal brain activity was related to improved balance performance across age groups, indicating that higher activity of the prefrontal cortex during balancing reflects neural inefficiency. 

We also present evidence supporting that age serves as a moderator in the relationship between brain activity and balance, i.e., cortical hemodynamics generally appears to be a more important predictor of balance performance in the older than in the younger. Strikingly, we found that age differences in balance performance are mediated by balancing-induced activation of the superior frontal gyrus, thus suggesting that differential activation of this region reflects a mechanism involved in the aging process of the neural control of balance. 

Our study suggests that differences in functional brain activity between age groups are not a mere by-product of aging, but instead of direct behavioral relevance for balance performance. 
Potential implications of these findings in terms of early detection of fall-prone individuals and intervention strategies targeting balance and healthy aging are discussed.
KW  - aging
KW  - neuroimaging
KW  - functional near-infrared spectroscopy (fNIRS)
KW  - balance
KW  - postural control
KW  - prefrontal cortex
KW  - neural inefficiency
Y1  - 2022
U6  - https://doi.org/10.3389/fnagi.2022.828474
SN  - 1663-4365
VL  - 14
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Herold, Fabian
A1  - Labott, Berit K.
A1  - Grässler, Bernhard
A1  - Halfpaap, Nicole
A1  - Langhans, Corinna
A1  - Müller, Patrick
A1  - Ammar, Achraf
A1  - Dordevic, Milos
A1  - Hökelmann, Anita
A1  - Müller, Notger Germar
T1  - A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
JF  - Healthcare : open access journal
N2  - Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
KW  - MCI
KW  - hippocampal-prefrontal network
KW  - handgrip strength
KW  - exercise cognition
KW  - aging
KW  - brain health
Y1  - 2022
U6  - https://doi.org/10.3390/healthcare10020230
SN  - 2227-9032
VL  - 10
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel, Schweiz
ET  - 2
ER  - 
TY  - JOUR
A1  - Spiegel, Thomas J.
T1  - The Scientific Weltanschauung
BT  - (Anti-)Naturalism in Dilthey, Jaspers and Analytic Philosophy
JF  - Journal of Transcendental Philosophy
N2  - Different forms of methodological and ontological naturalism constitute the current near-orthodoxy in analytic philosophy. Many prominent figures have called naturalism a (scientific) image (Sellars, W. 1962. “Philosophy and the Scientific Image of Man.” In Wilfrid Sellars, Science, Perception, Reality, 1–40. Ridgeview Publishing), a Weltanschauung (Loewer, B. 2001. “From Physics to Physicalism.” In Physicalism and its Discontents, edited by C. Gillett, and B. Loewer. Cambridge: Cambridge University Press; Stoljar, D. 2010. Physicalism. Routledge), or even a “philosophical ideology” (Kim, J. 2003. “The American Origins of Philosophical Naturalism.” Journal of Philosophical Research 28: 83–98). This suggests that naturalism is indeed something over-and-above an ordinary philosophical thesis (e.g. in contrast to the justified true belief-theory of knowledge). However, these thinkers fail to tease out the host of implications this idea – naturalism being a worldview – presents. This paper draws on (somewhat underappreciated) remarks of Dilthey and Jaspers on the concept of worldviews (Weltanschauung, Weltbild) in order to demonstrate that naturalism as a worldview is a presuppositional background assumption which is left untouched by arguments against naturalism as a thesis. The concluding plea is (in order to make dialectical progress) to re-organize the existing debate on naturalism in a way that treats naturalism not as a first-order philosophical claim, but rather shifts its focus on naturalism’s status as a worldview.
KW  - naturalism
KW  - ideology
KW  - Dilthey
KW  - Jaspers
KW  - scientific image
KW  - worldview
Y1  - 2021
U6  - https://doi.org/10.1515/jtph-2021-0016
SN  - 2626-8329
SN  - 2626-8310
VL  - 2
IS  - 2
SP  - 259
EP  - 276
PB  - De Gruyter
CY  - Berlin ; Boston
ER  - 
TY  - JOUR
A1  - Wachs, Sebastian
A1  - Wright, Michelle F.
A1  - Sittichai, Ruthaychonnee
A1  - Singh, Ritu
A1  - Biswal, Ramakrishna
A1  - Kim, Eun-mee
A1  - Yang, Soeun
A1  - Gámez-Guadix, Manuel
A1  - Almendros, Carmen
A1  - Flora, Katerina
A1  - Daskalou, Vassiliki
A1  - Maziridou, Evdoxia
T1  - Associations between witnessing and perpetrating online hate in eight countries
BT  - the buffering effects of problem-focused coping
JF  - International Journal of Environmental Research and Public Health
N2  - Online hate is a topic that has received considerable interest lately, as online hate represents a risk to self-determination and peaceful coexistence in societies around the globe. However, not much is known about the explanations for adolescents posting or forwarding hateful online material or how adolescents cope with this newly emerging online risk. Thus, we sought to better understand the relationship between a bystander to and perpetrator of online hate, and the moderating effects of problem-focused coping strategies (e.g., assertive, technical coping) within this relationship. Self-report questionnaires on witnessing and committing online hate and assertive and technical coping were completed by 6829 adolescents between 12 and 18 years of age from eight countries. The results showed that increases in witnessing online hate were positively related to being a perpetrator of online hate. Assertive and technical coping strategies were negatively related with perpetrating online hate. Bystanders of online hate reported fewer instances of perpetrating online hate when they reported higher levels of assertive and technical coping strategies, and more frequent instances of perpetrating online hate when they reported lower levels of assertive and technical coping strategies. In conclusion, our findings suggest that, if effective, prevention and intervention programs that target online hate should consider educating young people about problem-focused coping strategies, self-assertiveness, and media skills. Implications for future research are discussed.
KW  - online hate
KW  - hate speech
KW  - bystander
KW  - perpetrator
KW  - coping strategies
KW  - cyber aggression
Y1  - 2019
U6  - https://doi.org/10.3390/ijerph16203992
SN  - 1660-4601
VL  - 16
IS  - 20
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Balint, Miklos
A1  - Marton, Orsolya
A1  - Schatz, Marlene
A1  - Düring, Rolf-Alexander
A1  - Grossart, Hans-Peter
T1  - Proper experimental design requires randomization/balancing of molecular ecology experiments
JF  - Ecology and evolution
N2  - Properly designed (randomized and/or balanced) experiments are standard in ecological research. Molecular methods are increasingly used in ecology, but studies generally do not report the detailed design of sample processing in the laboratory. This may strongly influence the interpretability of results if the laboratory procedures do not account for the confounding effects of unexpected laboratory events. We demonstrate this with a simple experiment where unexpected differences in laboratory processing of samples would have biased results if randomization in DNA extraction and PCR steps do not provide safeguards. We emphasize the need for proper experimental design and reporting of the laboratory phase of molecular ecology research to ensure the reliability and interpretability of results.
KW  - batch effect
KW  - bias
KW  - DNA extraction
KW  - environmental DNA
KW  - laboratory practice
KW  - lake community
KW  - metabarcoding
KW  - nondemonic intrusions
KW  - PCR
KW  - sediment
Y1  - 2018
U6  - https://doi.org/10.1002/ece3.3687
SN  - 2045-7758
VL  - 8
IS  - 3
SP  - 1786
EP  - 1793
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Bizic-Ionescu, Mina
A1  - Ionescu, Danny
A1  - Grossart, Hans-Peter
T1  - Organic Particles: Heterogeneous Hubs for Microbial Interactions in Aquatic Ecosystems
JF  - Frontiers in microbiology
N2  - The dynamics and activities of microbes colonizing organic particles (hereafter particles) greatly determine the efficiency of the aquatic carbon pump. Current understanding is that particle composition, structure and surface properties, determined mostly by the forming organisms and organic matter, dictate initial microbial colonization and the subsequent rapid succession events taking place as organic matter lability and nutrient content change with microbial degradation. We applied a transcriptomic approach to assess the role of stochastic events on initial microbial colonization of particles. Furthermore, we asked whether gene expression corroborates rapid changes in carbon-quality. Commonly used size fractionated filtration averages thousands of particles of different sizes, sources, and ages. To overcome this drawback, we used replicate samples consisting each of 3–4 particles of identical source and age and further evaluated the consequences of averaging 10–1000s of particles. Using flow-through rolling tanks we conducted long-term experiments at near in situ conditions minimizing the biasing effects of closed incubation approaches often referred to as “the bottle-effect.” In our open flow-through rolling tank system, however, active microbial communities were highly heterogeneous despite an identical particle source, suggesting random initial colonization. Contrasting previous reports using closed incubation systems, expression of carbon utilization genes didn’t change after 1 week of incubation. Consequently, we suggest that in nature, changes in particle-associated community related to carbon availability are much slower (days to weeks) due to constant supply of labile, easily degradable organic matter. Initial, random particle colonization seems to be subsequently altered by multiple organismic interactions shaping microbial community interactions and functional dynamics. Comparative analysis of thousands particles pooled togethers as well as pooled samples suggests that mechanistic studies of microbial dynamics should be done on single particles. The observed microbial heterogeneity and inter-organismic interactions may have important implications for evolution and biogeochemistry in aquatic systems.
KW  - particle-associated bacteria
KW  - microbial communities
KW  - inter- and intra-species interactions
KW  - antagonism
KW  - phage
KW  - transcriptome
Y1  - 2018
U6  - https://doi.org/10.3389/fmicb.2018.02569
SN  - 1664-302X
VL  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wurzbacher, Christian
A1  - Fuchs, Andrea
A1  - Attermeyer, Katrin
A1  - Frindte, Katharina
A1  - Grossart, Hans-Peter
A1  - Hupfer, Michael
A1  - Casper, Peter
A1  - Monaghan, Michael T.
T1  - Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment
JF  - Microbiome
N2  - Background: Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic composition to sediment biogeochemical parameters, test whether community turnover with depth resulted from taxonomic replacement or from richness effects, and to provide a basic model for the vertical community structure in sediments. Methods: We analyzed four replicate sediment cores taken from 30-m depth in oligo-mesotrophic Lake Stechlin in northern Germany. Each 30-cm core spanned ca. 170 years of sediment accumulation according to Cs-137 dating and was sectioned into layers 1-4 cm thick. We examined a full suite of biogeochemical parameters and used DNA metabarcoding to examine community composition of microbial Archaea, Bacteria, and Eukaryota. Results: Community beta-diversity indicated nearly complete turnover within the uppermost 30 cm. We observed a pronounced shift from Eukaryota- and Bacteria-dominated upper layers (<5 cm) to Bacteria-dominated intermediate layers (5-14 cm) and to deep layers (>14 cm) dominated by enigmatic Archaea that typically occur in deep-sea sediments. Taxonomic replacement was the prevalent mechanism in structuring the community composition and was linked to parameters indicative of microbial activity (e.g., CO2 and CH4 concentration, bacterial protein production). Richness loss played a lesser role but was linked to conservative parameters (e.g., C, N, P) indicative of past conditions. Conclusions: By including all three domains, we were able to directly link the exponential decay of eukaryotes with the active sediment microbial community. The dominance of Archaea in deeper layers confirms earlier findings from marine systems and establishes freshwater sediments as a potential low-energy environment, similar to deep sea sediments. We propose a general model of sediment structure and function based on microbial characteristics and burial processes. An upper "replacement horizon" is dominated by rapid taxonomic turnover with depth, high microbial activity, and biotic interactions. A lower "depauperate horizon" is characterized by low taxonomic richness, more stable "low-energy" conditions, and a dominance of enigmatic Archaea.
KW  - Archaea
KW  - Eukaryota
KW  - Bacteria
KW  - Community
KW  - Freshwater
KW  - Lake
KW  - DNA metabarcoding
KW  - Beta-diversity
KW  - Sediment
KW  - Turnover
Y1  - 2017
U6  - https://doi.org/10.1186/s40168-017-0255-9
SN  - 2049-2618
VL  - 5
PB  - BioMed Central
CY  - London
ER  -