TY - JOUR A1 - Heisig, Jan Paul A1 - Matthewes, Sönke Hendrik T1 - No evidence that strict educational tracking improves student performance through classroom homogeneity BT - a critical reanalysis of Esser and Seuring (2020) BT - eine kritische Reanalyse von Esser und Seuring (2020) JF - Zeitschrift für Soziologie N2 - In a recent contribution to this journal, Esser and Seuring (2020) draw on data from the National Educational Panel Study to attack the widespread view that tracking in lower secondary education exacerbates inequalities in student outcomes without improving average student performance. Exploiting variation in the strictness of tracking across 13 of the 16 German federal states (e. g., whether teacher recommendations are binding), Esser and Seuring claim to demonstrate that stricter tracking after grade 4 results in better performance in grade 7 and that this can be attributed to the greater homogeneity of classrooms under strict tracking. We show these conclusions to be untenable: Esser and Seuring's measures of classroom composition are highly dubious because the number of observed students is very small for many classrooms. Even when we adopt their classroom composition measures, simple corrections and extensions of their analysis reveal that there is no meaningful evidence for a positive relationship between classroom homogeneity and student achievement - the channel supposed to mediate the alleged positive effect of strict tracking. We go on to show that students from more strictly tracking states perform better already at the start of tracking (grade 5), which casts further doubt on the alleged positive effect of strict tracking on learning progress and leaves selection or anticipation effects as more plausible explanations. On a conceptual level, we emphasize that Esser and Seuring's analysis is limited to states that implement different forms of early tracking and cannot inform us about the relative performance of comprehensive and tracked systems that is the focus of most prior research. N2 - In einem kürzlich in dieser Zeitschrift veröffentlichten Artikel attackieren Esser und Seuring (2020) die verbreitete Auffassung, dass eine frühe Leistungsdifferenzierung in den ersten Jahren der Sekundarstufe Ungleichheiten zwischen Schüler*innen verstärkt, ohne sich positiv auf das durchschnittliche Leistungsniveau auszuwirken. Auf Basis einer Analyse von Daten des Nationalen Bildungspanels für 13 Bundesländer kommen die Autoren zu dem Ergebnis, dass sich eine strenge Leistungsdifferenzierung (z. B. durch bindende Grundschulempfehlungen) positiv auf das Leistungsniveau in Klasse 7 auswirkt und dass dies auf die homogenere Klassenzusammensetzung in strikt differenzierenden Ländern zurückgeführt werden kann. Der vorliegende Beitrag zeigt, dass diese Schlussfolgerungen nicht haltbar sind: Esser und Seurings Indikatoren für die Klassenzusammensetzung sind qualitativ fragwürdig, da die Anzahl gültiger Beobachtungen für viele Klassen sehr klein ist. Selbst bei Verwendung ihrer Indikatoren wird durch einfache Korrekturen und Ergänzungen ihrer Analyse schnell deutlich, dass es keine belastbaren empirischen Belege für den theoretisch zentralen positiven Zusammenhang zwischen homogener Klassenzusammensetzung und Leistungsniveau gibt. Zudem können wir zeigen, dass Schüler*innen in streng differenzierenden Ländern bereits zu Beginn der Sekundarstufe bessere Leistungen erzielen, ein weiteres Ergebnis, das gegen einen (kausalen) positiven Zusammenhang zwischen strenger Differenzierung und Lernfortschritt und für Alternativerklärungen wie Selektions- oder Antizipationseffekte spricht. In konzeptioneller Hinsicht heben wir hervor, dass sich die Analyse von Esser und Seuring auf verschiedene leistungsdifferenzierende Systeme beschränkt und insofern keine unmittelbaren Implikationen für den in der Literatur zentralen Vergleich zwischen differenzierenden und Gesamtschulsystemen (comprehensive systems) haben kann. T2 - Keine Belege für leistungsfördernde Effekte von strikter Leistungsdifferenzierung durch kognitive Homogenisierung KW - Ability Tracking KW - Secondary Education Systems KW - Peer Effects KW - Classroom KW - Composition KW - Mediation Analysis KW - Replication KW - Leistungsdifferenzierung KW - Sekundarbildungssysteme KW - Peer-Effekte KW - Klassenzusammensetzung KW - Mediationsanalyse KW - Replikation Y1 - 2022 U6 - https://doi.org/10.1515/zfsoz-2022-0001 SN - 0340-1804 SN - 2366-0325 VL - 51 IS - 1 SP - 99 EP - 111 PB - de Gruyter Oldenbourg CY - Berlin ER - TY - JOUR T1 - Über die Autoren T1 - Concerning the authors T1 - Sobre los autores Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-51859 SN - 1617-5239 SN - 2568-3543 VL - XI IS - 21 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Über die Autoren T1 - Concerning the authors T1 - Sobre los autores T1 - Sur les auteurs Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-68120 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 68 EP - 69 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kröger, Björn T1 - Remarks on a scene, depicting the primeval world BT - A talk given by Leopold von Buch in 1831, popularizing the Duria antiquior JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - The Prussian geologist Leopold von Buch was a lifelong friend of Alexander von Humboldt and had a significant influence on Humboldt’s geological ideas. In a talk, held in Berlin in 1831, which is published here for the first time, von Buch presented the Duria Antiquior of 1830 by the English geologist Henry De La Beche. The Duria Antiquior is widely regarded as the earliest depiction of a scene of prehistoric life from deep time. The print raised new questions about the processes of geohistorical change. The talk reveals that Leopold von Buch was a true scientist of the Romantic Age. His descriptions of geohistorical organismic transformations are taken from pictorial examples of organismic transformation from the classical literature. The talk also illustrates how influential English geologists were for geo-historical reconstructions in Germany. N2 - Der Geologe Leopold von Buch war lebenslanger Freund Alexander von Humboldts und hatte wesentlichen Anteil an dessen Verständnis erdgeschichtlicher Prozesse. In einem hier erstmals veröffentlichten Vortrag, gehalten 1831 in Berlin, stellt von Buch die 1830 publizierte Duria Antiquior des englischen Geologen Henry De La Beche vor. Das Bild gilt als erste wissenschaftliche Rekonstruktion einer vorzeitlichen Welt und warf mit seinem Erscheinen neue Fragen zu den Prozessen erdgeschichtlicher Veränderungen auf. Leopold von Buch zeigt sich in dem Vortrag als Forscher der Romantik, der mit der Duria Antiquior vorhandene bildhafte Vorstellungen organismischer Transformation aus der Literatur aufgriff, um geohistorische Veränderungen der Lebewesen zu beschreiben. Mit dem Vortrag wird der große Einfluss deutlich, den die Engländer auf die zeitgenössischen Erzählungen der Erdgeschichte in Deutschland hatten. N2 - Le géologue prussien Leopold von Buch a noué une longue amitié avec Alexander von Humboldt, il a grandement influencé les idées dans le domaine de la géologie. Dans une conférence donnée en 1831 à Berlin et dont le texte est publié ici pour la première fois, von Buch a présenté le Duria Antiquior du géologue anglais Henry de la Beche. Cette oeuvre est très largement considérée comme la plus ancienne représentation d‘une scène de vie préhistorique. Elle a contribué à initier de nombreuses réflexions à propos des processus de changement géohistorique. L‘exposé de 1831 à Berlin permet de mettre en évidence que von Buch était un scientifique influencé par le romantisme. Ses descriptions des transformations organismiques géohistoriques s‘appuient sur des exemples figurés dans la littérature classique. Son exposé illustre également combien l‘influence des géologues anglais sur les reconstitutions géohistoriques était forte alors en Allemagne. KW - 1830 KW - Berlin KW - Duria Antiquio KW - Erdgeschichte KW - Geologie KW - Henry De La Beche KW - Leopold von Buch KW - Naturgeschichte KW - Transmutation KW - Vortrag KW - Zeitgenossen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-69848 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 7 EP - 35 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Beck, Hanno T1 - Das literarische Testament Alexander von Humboldts 1799 JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies KW - Literarisches Testament KW - neu gelesen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70126 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 87 EP - 95 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schmuck, Thomas T1 - Tod in den Anden BT - Ein Brief Francis Halls an Humboldt 1831 und seine historischen und politischen Hintergründe JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - Der Forschungsreisende Francis Hall kam als Soldat nach Südamerika und betätigte sich hier auch als Pflanzensammler, Reiseschriftsteller und Bergsteiger. Er war Freund und Briefpartner Jeremy Benthams und versuchte gemeinsam mit Jean-Baptiste Boussingault den Chimborazo zu besteigen. Der liberale Journalist wurde 1833 in bürgerkriegsähnlichen Unruhen in Ecuador ermordet. Der einzige Brief Halls an Humboldt, in dem er diesen für die Naturerschließung des Landes zu gewinnen versucht, eine Sammlung andiner Pflanzen übersendet und seine Einschätzung zur politischen Lage und Zukunft Südamerikas kundtut, wird hier veröffentlicht und kommentiert. N2 - The British explorer Francis Hall was active in South- America as a soldier, a collector of plants, a writer of travelogues and a mountaineer. Together with Jean- Baptiste Boussingault he failed in ascending the Chimborazo. Friend and correspondent of Jeremy Bentham and also liberal journalist, Hall was killed during riots in Ecuador in 1833. In one single letter addressed to Humboldt, which is presented here, Hall tries to awaken interest for Ecuador, develops his views on the political future of South America and sends a collection of plants from the Andes. N2 - El explorador británico Francis Hall llegó a América del Sur como soldado y allí también se dedicó a la colección de plantas, a escribir sobre viajes y a hacer alpinismo. Intentó subir al Chimborazo con Jean-Baptiste Boussingault. El periodista liberal, amigo de Jeremy Bentham con el que también mantenía correspondencia, fue asesinado en los disturbios de 1833 en Ecuador. En la única carta de Hall a Humboldt, que está publicada y comentada aquí, Hall intenta despertar el interés de Humboldt por la naturaleza del país enviando una colección de plantas andinas y dando su opinión sobre la situación política y el futuro de América del Sur. (Traducción: Christine Lebas) KW - Anden KW - Briefwechsel KW - Francis Hall KW - Freunde Humboldts KW - Jean-Baptiste Boussingault KW - Jeremy Bentham KW - Zeitgenossen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70061 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 55 EP - 68 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Roussanova, Elena T1 - Hermann Trautschold und die Ehrung Alexander von Humboldts in Russland JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - Der 100. Geburtstag von Alexander von Humboldt im Jahre 1869 wurde in Russland groß gefeiert, besonders von der Société Impériale des Naturalistes de Moscou. Der spätere Sekretär dieser Gesellschaft, Hermann Trautschold, hielt damals eine vielbeachtete Lobrede auf den weltbekannten deutschen Naturforscher und Forschungsreisenden. Im Fokus des Aufsatzes steht der deutsch-russische Geologe und Paläontologe Trautschold sowie seine im Jahre 1869 in Moskau gehaltene Lobrede. N2 - The 100th anniversary of Alexander von Humboldt in 1869 was enthusiastically celebrated in Russia, especially by the Société Impériale des Naturalistes de Moscou. Hermann Trautschold who became secretary of this society later on, presented a remarkable eulogy of the world-famous naturalist and explorer. The article focuses on the German-Russian geologist and paleontologist Trautschold and his eulogy delivered in Moscow in 1869. N2 - 100-летие со дня рождения Александра фон Гумбольдта в 1869 году широко отмечалось в России, особенно в Императорском Московском обществе испытателей природы. Герман Траутшольд, ставший через некоторое время секретарём этого общества, произнёс тогда торжественную речь, посвящённую всемирно известному немецкому натуралисту и путешественнику. Основное внимание в статье сосредоточено на немецко-русском геологе и палеонтологе Траутшольде и его в 1869 году в Москве произнесенной речи. KW - 100. Geburtstag KW - Hermann Trautschold KW - Moskau KW - Paläontologie KW - Rußland KW - Société Impériale des Naturalistes de Moscou Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70083 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 36 EP - 54 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Thiemer-Sachse, Ursula T1 - „Wir verbrachten mehr als 24 Stunden, ohne etwas anderes als Schokolade und Limonade zu uns zu nehmen“ BT - Hinweise in Alexander von Humboldts Tagebuchaufzeichnungen zu Fragen der Verpflegung auf der Forschungsreise durch Spanisch-Amerika JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - In Alexander von Humboldts Tagebüchern seiner berühmten Forschungsreise durch Spanisch-Amerika finden sich Bemerkungen und Hinweise für künftige Leser seiner Reisedarstellungen zu Problemen der Verpflegung. Zumeist werden Engpässe und Missstände erwähnt sowie Fragen soziopolitischer Situation verdeutlicht. Sie beziehen sich auf Extrembedingungen in stadtfernen Gebieten und im Kontakt mit den indigenen Trägern und Helfern während der einzelnen Exkursionen. Die Darstellungen der alltäglichen Gegebenheiten sind zugleich eine interessante Quelle für Verhaltensmuster der verschiedenen Schichten der spanischkolonialen Gesellschaft wie der Forschungsreisenden, die mit den Schwierigkeiten umzugehen hatten, sich anzupassen verstanden oder ihre eigenen Verhaltensmuster entwickelt haben. Damit ermöglichen Humboldts Aufzeichnungen zugleich auch auf diesem Gebiet manchen Blick auf den seither erfolgten Kulturwandel. N2 - In the diaries of Alexander von Humboldt’s famous expedition throughout Spanish America you will find observations and notes about problems of food supply, which seem to be directed at future readers of his later to be published travelogue. In most instances, he mentions precarious situations and illustrates questions of sociopolitical nature. Frequently, his notes refer to extreme conditions in remote regions and in contact with the indigenous porters (cargadores) and assistants in the course of the different excursions. At the same time, the descriptions of everyday life are an interesting source for the study of different social strata in colonial Spanish society. This also accounts for the researchers themselves, who had to face the challenges of their journey, either accommodating themselves or developing strategies of adaption. Humboldt’s notes also enable the present-day reader to shed a light on transformations in everyday culture and social behaviour. N2 - En los diarios del famoso viaje de estudios de Alejandro de Humboldt por la América española se encuentran observaciones y notas sobre problemas de aprovisionamiento, en favor de lectores futuros de sus relaciones de viaje. En la mayoría de los casos Humboldt menciona situaciones precarias o ilustra cuestiones de carácter sociopolítico. Frecuentemente, sus apuntes se refieren a condiciones extremas en regiones remotas y en contacto con los cargadores y ayudantes indígenas durante las diferentes excursiones. Las descripciones de los acontecimientos cotidianos al mismo tiempo son una fuente interesante sobre los modos de proceder de las diferentes capas de la sociedad colonial española así como de los viajeros científicos que tuvieron que enfrentar dificultades a las cuales había que adaptarse o desarrollar modelos propios de comportamiento. Por esto al mismo tiempo las noticias de Humboldt también en este asunto posibilitan más de una vez la atención al cambio cultural que se ha realizado hasta hoy en día. KW - Amerika-Reise KW - Forschungsreise KW - Reisetagebuch KW - Verpflegung Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70106 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 77 EP - 83 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schwarz, Ingo T1 - Hanno Beck zum 90. Geburtstag JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies KW - Hanno Beck KW - zum Geburtstag Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70113 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 84 EP - 86 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Über die Autoren T1 - Concerning the authors T1 - Sobre los autores T1 - Sur les auteurs Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-71271 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 68 EP - 69 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schnöpf, Markus T1 - Evaluationskriterien für digitale Editionen und die reale Welt JF - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - In den letzten Jahren sind immer mehr Editionen im Internet erschienen. Sie zeigen eine ähnlich große Vielfalt wie gedruckte Editionen. Somit ist es an der Zeit, den Begriff der digitalen Edition zu schärfen. Wie können digitale Editionen eingeordnet und evaluiert werden? Wie können neben editionswissenschaftlichen Kriterien weitere Bewertungssysteme dazu beitragen, qualitative Unterschiede zwischen den vorhandenen Editionen herauszuarbeiten? Das Institut für Dokumentologie und Editorik hat dazu einen Kriterienkatalog erstellt, der in diesem Beitrag einerseits vorgestellt werden soll, andererseits an bestehende Projekte angewendet werden soll. Ziel dieser Übung ist, den Blick auf digital vorliegende Quellen zu schärfen. N2 - Since recent years more and more editions are published on the internet. They show a similarly wide variety such as printed editions. Thus, it is time to sharpen the concept of a digital edition. How can digital editions be classified and evaluated? How can criteria besides of traditional textual scholarship help to bring out qualitative differences between the available editions? The Institute for Documentology and Scholarly Editing has developed a list of criteria that will be presented in this paper on the one hand, on the other hand this list will be applied to existing projects. The aim of this exercise is to sharpen the focus on digitally available sources. N2 - En los últimos años, más y más ediciones se publican en el Internet. Muestran una igualmente amplia variedad como ediciones impresas. Por lo tanto, es el momento para afilar el concepto de la edición digital. ¿Cómo se puede clasificar y evalúar las ediciones digitales? ¿Cómo pueden sistemas de clasificación - además de las criterias de la Editionswissenschaft - ayudar a iluminar las diferencias cualitativas entre las ediciones disponibles? El Instituto para Editorica y Documentología ha creado una lista de criterios que se presentan en este trabajo, por un lado, por otro lado se va a aplicar esta lista a proyectos existentes. El objetivo de este ejercicio es creer más hincapié en las fuentes digitales disponibles. KW - Digital Humanities KW - Digitale Edition KW - Editionswissenschaft KW - Institut für Dokumentologie Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70091 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 27 SP - 69 EP - 76 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Mönnich, Katja T1 - Eine Freundschaft, die Jahrzehnte überdauerte! BT - Ein unveröffentlichter Brief Alexander von Humboldts an seinen langjährigen Freund Johann Karl Freiesleben JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies N2 - Der vorliegende Brief Alexander von Humboldts an seinen Jugendfreund Johann Karl Freiesleben (1774-1846) reiht sich ein in das Vorhaben, unpublizierte Briefe aus Humboldts Jugendzeit der Öffentlichkeit zugänglich zu machen. Editorisch fügt sich der Brief in die von Ilse Jahn und Fritz Gustav Lange herausgegebenen Jugendbriefe Alexander von Humboldts 1787-1799 ein. In diesem Band findet der Brief seinen Platz zwischen zwei Briefen Humboldts an Freiesleben, die er während seines Aufenthaltes in Dresden am 10.07.1797 sowie am 11. oder 18.07.1797 geschrieben hat. N2 - The letter of Alexander von Humboldt to his childhood friend Johann Karl Freiesleben (1774-1846) is part of the project of making unpublished letters from Humboldt’s youth accessible to the public. Editorially, the letter fits in the edition Jugendbriefe Alexander von Humboldts 1787-1799, published by Ilse Jahn and Fritz Gustav Lange. In this volume, the letter is placed between two letters from Humboldt to Freiesleben, which he wrote during his stay in Dresden on 10th of July and on 11th or 18th of July 1797. N2 - La carta de Alexander von Humboldt a su amigo de juventud Johann Karl Freiesleben (1774-1846) es parte del proyecto de investigación, que presenta cartas del joven Humboldt todavía no publicadas. Editorialmente, la carta fue adaptada a la publicación de la edición Jugendbriefe Alexander von Humboldts 1787-1799, presentada por Ilse Jahn y Fritz Gustav Lange. En este volumen, la carta está ubicada entre dos cartas de Humboldt a Freiesleben, que escribió en Dresde el 10 de julio y el 11 o 18 de julio 1797. KW - Fritz Gustav Lange KW - Ilse Jahn KW - Johann Karl Freiesleben KW - Jugendbriefe KW - von Humboldts Hand Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66716 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 6 EP - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Doherr, Detlev T1 - Interconnectedness und digitale Texte JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies N2 - Die multimedialen Informationsdienste im Internet werden immer umfangreicher und umfassender, wobei auch die nur in gedruckter Form vorliegenden Dokumente von den Bibliotheken digitalisiert und ins Netz gestellt werden. Über Online-Dokumentenverwaltungen oder Suchmaschinen können diese Dokumente gefunden und dann in gängigen Formaten wie z.B. PDF bereitgestellt werden. Dieser Artikel beleuchtet die Funktionsweise der Humboldt Digital Library, die seit mehr als zehn Jahren Dokumente von Alexander von Humboldt in englischer Übersetzung im Web als HDL (Humboldt Digital Library) kostenfrei zur Verfügung stellt. Anders als eine digitale Bibliothek werden dabei allerdings nicht nur digitalisierte Dokumente als Scan oder PDF bereitgestellt, sondern der Text als solcher und in vernetzter Form verfügbar gemacht. Das System gleicht damit eher einem Informationssystem als einer digitalen Bibliothek, was sich auch in den verfügbaren Funktionen zur Auffindung von Texten in unterschiedlichen Versionen und Übersetzungen, Vergleichen von Absätzen verschiedener Dokumente oder der Darstellung von Bilden in ihrem Kontext widerspiegelt. Die Entwicklung von dynamischen Hyperlinks auf der Basis der einzelnen Textabsätze der Humboldt‘schen Werke in Form von Media Assets ermöglicht eine Nutzung der Programmierschnittstelle von Google Maps zur geographischen wie auch textinhaltlichen Navigation. Über den Service einer digitalen Bibliothek hinausgehend, bietet die HDL den Prototypen eines mehrdimensionalen Informationssystems, das mit dynamischen Strukturen arbeitet und umfangreiche thematische Auswertungen und Vergleiche ermöglicht. N2 - The multimedia information services on Internet are becoming more and more comprehensive, even the printed documents are digitized and republished as digital Web documents by the libraries. Those digital files can be found by search engines or management tools and provided as files in usual formats as PDF. This article focuses on the functionality of the Humboldt Digital Library (HDL), which is available for more than a decade and which provides digitized documents of Alexander von Humboldt in the English translations. Unlike a digital library, the HDL doesn’t provide only digitized documents as PDF or image formats with book scans, but the text itself is made ​​available as such and embedded into an information network. Therefore the system is representing an information system rather than a digital library, which is also reflected by the implemented functions for the search of texts in different versions and translations, comparisons of paragraphs of different documents or presentation of images in their contexts. The development of dynamic hyperlinks, based on the individual paragraphs in the Humboldt works in the form of media assets, enables the use of the Application Programming Interface (API) of Google Maps for geographical as well as text content navigation. Beyond the services of a digital library the HDL provides a prototype of a multi-dimensional information system that works with dynamic structures and enables extensive thematic research and comparisons. N2 - Los servicios de información multimedia en Internet se están convirtiendo cada vez más comprensivos, incluso los documentos impresos son digitalizados y republicados, por las bibliotecas, como documentos Web digitales. Estos archivos digitales pueden ser encontrados por máquinas de búsqueda o herramientas administrativas, y proveerlos como archivos en formatos comunes como PDF. Este artículo se enfoca en la funcionalidad de la Biblioteca Digital Humboldt (HDL=Humboldt Digital Library), la cual está disponible por más de una década y provee documentos digitalizados de Alexander von Humboldt traducidos al inglés. A diferencia de una biblioteca digital, la HDL no provee solamente documentos digitales en PDF o en formatos de imagen de libros escaneados, sino el texto en sí mismo se pone a disposición como tal y embebido en una red de información. Por lo tanto, el sistema representa un sistema de información más que una biblioteca digital, lo cual se muestra también por las funciones implementadas para el descubrimiento de textos en diferentes versiones y traducciones, comparaciones de párrafos de diferentes documentos o la presentación de imágenes en su contexto. El desarrollo de hyperlinks dinámicos basado en párrafos individuales de los trabajos de Humboldt, trabaja en la forma de media assets, permite el uso de Interface de Aplicación Programada (API=Application Programming Interface) de Google Maps para navegación tanto geográfica así como de contenido de texto. Más allá de servicios de biblioteca digital, la HDL proporciona un prototipo de un sistema de información multi-dimensional que funciona con estructuras dinámicas y habilita vastas evaluaciones y comparaciones temáticas. KW - Digital Humanities KW - Digitalisierung KW - Humboldt Digital Library Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66728 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 13 EP - 19 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Thiemer-Sachse, Ursula T1 - Steinpatrizen aus dem alten Kolumbien zur Vorbereitung des Gusses von Goldobjekten in verlorener Form BT - Alexander von Humboldts „Kalendersteine“ der Muisca JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies N2 - Im vorspanischen Zentralkolumbien, vor allem in der Muisca-Kultur, wurden Hochreliefs auf Steinpatrizen zur Abformung von Wachsmatrizen für den Guss in verlorener Form benutzt, die Alexander von Humboldt irrtümlich für „Kalendersteine“ der Muisca hielt. Der wissenschaftsgeschichtliche Überblick beschäftigt sich mit den Ursachen dieses Irrtums und dessen Überwindung. N2 - In pre-Hispanic central Colombia, especially in the region of the Muiscan culture, there were high reliefs on stone patrixes used for molding stencils (matrixes) to found metals with the lost wax casting method. Alexander von Humboldt understood them as “calendar stones” of the Muisca. A survey of the history of science considers the reasons for and the surmounting of this erroneous idea. N2 - En la región central de la Colombia prehispánica, especialmente en la cultura muisca, se utilizaron altos relieves en pátrices de piedra para moldear mátrices de cera para la fundición en cera perdida, erroneamente comprendidos por Alejandro de Humboldt como piedras de un “calendario” muisca. El conjunto de la historia de la ciencia trata de las causas y de la abnegación de esa idea. KW - Kolumbien KW - Musica KW - Wissenschaftsgeschichte Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66733 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 20 EP - 26 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schneider, Birgit T1 - Berglinien im Vergleich BT - Bemerkungen zu einem klimageografischen Diagramm Alexander von Humboldts JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies N2 - Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unveröffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gründen für die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen über den Forschungskontext des Diagramms, den epistemischen Stellenwert zeichnerischer Praktiken sowie über die heuristische Rolle der Berge und ihrer charakteristischen Profillinien in Humboldts Forschungen stellen. Gezeigt wird, wie das visuelle Denken und das Interesse Humboldts an neuen grafischen Methoden zu einer wichtigen Bedingung wurden, um die holistische Synopsis der Welt als ökologisches System erforschen und darstellen zu können. N2 - The article analyses from a visual studies and historical perspective the unpublished sketch of a mountain profile found among the handwritten papers of Alexander von Humboldt’s estate. The small sheet of sketches, with its pasted additions, was at the heart of climatic-geographic academic enquiry into the reasons for worldwide differences in the levels of mountain snow lines. The unfinished, sketchy nature of the diagramme raises questions about its research context, about the epistemic value of draughtsmanship practice and about the heuristic role of mountains and their characteristic profiles in Humboldt’s research. It becomes evident how Humboldt’s visual logic and his interest in new forms of graphics became important factors in investigation and depiction of the world as an ecological system. N2 - En el artículo se analizan los bocetos sin publicar de perspectivas históricas y de la ciencia de la imagen del diagrama montañoso de las obras póstumas escritas a mano de Alexander von Humboldt. La hoja de bocetos pegada de forma múltiple estaba situada en el centro de dudas geoclimatológicas por los fundamentos de los límites de nieve totalmente diferentes en las montañas de todo el mundo. A causa del carácter inacabado de los bocetos del diagrama, se cuestiona el contexto de investigación del diagrama, la importancia epistemológica de las prácticas gráficas y el papel heurístico de las montañas y sus característicos perfiles en las investigaciones de Humboldt. Se presenta el modo en que el pensamiento visual y el interés de Humboldt por nuevos métodos gráficos supone una condición importante para investigar y exponer la sinopsis holística del mundo en calidad de sistema ecológico. KW - Bergkunde KW - Bildwissenschaft KW - Handschriften KW - Klimageografie KW - Klimatologie KW - Skizzen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66745 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 27 EP - 44 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schwarz, Ingo T1 - Friedrich L. Brand BT - 1922 bis 2012 JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies KW - Alexander-von-Humboldt-Forschungsstelle KW - Auswahlbibliographie KW - Friedrich L. Brand KW - Herbert Pieper KW - Messverfahren KW - Nachruf Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66759 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 45 EP - 48 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Knobloch, Eberhard T1 - „Es wäre mir unmöglich nur ein halbes Jahr so zu leben wie er“ BT - Encke, Humboldt und was wir schon immer über die neue Berliner Sternwarte wissen wollten JF - HiN : Alexander von Humboldt im Netz ; International review for Humboldtian studies KW - Astronomie KW - astronomische Instrumente KW - Geschichte der Astronomie KW - Sternwarte KW - Wissenschaftsgeschichte KW - neu gelesen Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-66766 SN - 1617-5239 SN - 2568-3543 VL - XIV IS - 26 SP - 49 EP - 68 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Knobloch, Eberhard T1 - Publikationen von Herbert Pieper KW - Archimedes KW - BBAW KW - Mathematik KW - Zahlentheorie Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-42238 SN - 1617-5239 SN - 2568-3543 VL - IX IS - 16 SP - 5 EP - 9 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Über die Autoren T1 - Concerning the authors T1 - Sobre los autores Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-42991 SN - 1617-5239 SN - 2568-3543 VL - XI IS - 20 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Jobst, Anne T1 - "Briefe wie gemahlt" BT - Alexander von Humboldts Engagement für die Wahl Christian Gottfried Ehrenbergs als Mitglied des Institut de France N2 - Am 19. Dezember 1831 wurde der verdienstvolle Mikrobiologe Christian Gottfried Ehrenberg zum korrespondierenden Mitglied des Institut de France gewählt. Alexander von Humboldt, der Ehrenberg als Wissenschaftler hoch schätzte, hat sich energisch für diese Wahl eingesetzt. Ein Zeugnis seines Engagements ist ein Brief an den Mediziner Antoine Baron Portal (1742-1832), den er um seine Stimme bei der bevorstehenden Wahl bat. Die Geschichte der Wahl Ehrenbergs in Verbindung mit diesem Brief und die Gründe für Humboldts Interesse daran sollen hier kurz skizziert werden. N2 - 19 декабря 1831 года заслуженный микробиолог Христиан Готфрид Эренберг /1795 - 1876/ был избран членом-корреспондентом Института де Франс. Александер фон Гумбольдт, высоко ценивший Эренберга как учёного, энергично содействовал этому избранию. Свидетельством его ангажемента является письмо медику Антоану Барону Порталу /1742 - 1832/, в котором он просит его голоса в предстоящих выборах. Взаимосвязь истории избрания Эренберга и этого письма а также причины заинтересованности Гумбольдта в этом являются предметом этих кратких изложений. KW - 1831 KW - Antoine Baron Portal KW - Christian Gottfried Ehrenberg KW - Institut de France Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41654 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 6 EP - 9 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hampe Martínez, Teodoro T1 - Introducción al tema de enfoque "Humboldt y la América ilustrada" Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41661 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 10 EP - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hampe Martínez, Teodoro T1 - Humboldt y el mar peruano BT - Una exploración de su travesía de Lima a Guayaquil (1802/1803) N2 - La presencia del científico berlinés Alexander von Humboldt en las actuales Repúblicas del Ecuador y Perú (desde enero de 1802 hasta febrero de 1803) trajo consigo una serie de sustanciales aportes al conocimiento científico de ambas naciones. Bien sabido es que Humboldt, considerado desde aquella época un verdadero Universalgelehrter o «sabio universal», fue capaz de resumir los saberes de disciplinas tan variadas como la etnología, la arqueología, la lingüística, la mineralogía, la geología, la botánica, la oceanografía y la biología marina, entre otras. Con respecto al Océano Pacífico, sus aportaciones más importantes están vinculadas a la náutica y la cosmografía, entre las cuales destacan su determinación de la longitud del puerto del Callao y su teoría sobre el origen de las aguas frías de la Corriente Peruana. Aquí nos fijaremos especialmente en las incidencias personales y en los apuntes manuscritos que Humboldt realizó durante su navegación del Callao ?salida marítima de Lima? hasta Guayaquil, la cual tuvo lugar entre diciembre de 1802 y enero de 1803 a bordo de la corbeta real Castor, comandada por el teniente de fragata José de Moraleda y Montero. KW - 1802/1803 KW - Guayaquil KW - Lima Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41678 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 13 EP - 21 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ortiz Sotelo, Jorge T1 - Aportes de Humboldt BT - A la náutica y a la oceanografía peruana N2 - La corta estadía de Alexander von Humboldt en el Perú dejó su huella más notoria en el estudio que realizara del sistema de corrientes marítimas que fluyen delante de la costa peruana, bautizada en su honor Corriente de Humboldt o la Corriente Peruana. Para ello llevó a cabo varias mediciones de la temperatura de mar durante su viaje de Trujillo a Lima, durante su permanencia en El Callao, y en el viaje que realizó entre dicho puerto y Guayaquil a bordo de la corbeta de la Real Armada Castor. Por otro lado, con la colaboración de algunos oficiales de la Real Armada estacionados en El Callao realizó observaciones astronómicas que le permitieron determinar con mayor precisión la longitud del puerto de El Callao. En este trabajo se abordan estos aspectos de la presencia de Humboldt en el Perú. KW - Ozeanologie KW - Perú Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41686 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 23 EP - 31 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Puig-Samper, Miguel Ángel A1 - Rebok, Sandra T1 - Alejandro de Humboldt y España BT - La preparación de su viaje americano y sus vínculos con la ciencia española N2 - Este estudio ofrece una visión muy general de la estancia de Alexander von Humboldt en España en el primer semestre de 1799 así como de la preparación de su viaje americano durante ese espacio de tiempo. Gracias a diversos documentos que han podido ser localizados en el transcurso de un proyecto de investigación sobre este tema se han podido llenar unos vanos en la investigación humboldtiana. Se presentan los motivos por los que el prusiano, junto a su compañero de viaje francés Aimé Bonpland, emprendió el camino hacía la Península Ibérica, su itinerario y las actividades científicas llevadas a cabo por ellos. Además, se analiza el significado que para él tuvo su estancia en España, interpretado a partir de sus propios escritos, y se describe así mismo su colaboración con la comunidad científica de Madrid. Especial atención se ha puesto en detallar la preparación administrativa en Madrid de su expedición a América, así como los documentos creados y utilizados en este proceso. En el anexo se adjuntan dos documentos poco conocidos: la memoria entregada por Humboldt al rey Carlos IV y un pasaporte firmado por Mariano Luis de Urquijo. N2 - Diese Studie bietet einen allgemeinen Überblick über den Aufenthalt Alexander von Humboldts in Spanien Anfang 1799 sowie dort durchgeführte Vorbereitung seiner Amerika-Expedition. Dank einiger Dokumente, die im Rahmen eines Forschungsprojektes über dieses Thema aufgefunden wurden, konnten diesbezügliche Lücken in der Humboldtforschung geschlossen werden. In diesem Beitrag werden die Motive angesprochen, die dazu führten, dass der Preuße zusammen mit seinem französischen Reisegefährten Aimé Bonpland auf die Iberische Halbinsel kam, desweiteren wird ihre Reiseroute skizziert sowie die unterdessen durchgeführten wissenschaftlichen Messungen. Zudem wird mit Hilfe von Humboldts eigenen Aufzeichnungen die Bedeutung thematisiert, die diese Spanienreise für ihn hatte und auf seine Zusammenarbeit mit den vor allem in Madrid ansässigen Wissenschaftlern eingegangen. Eine besondere Aufmerksamkeit erfährt die detaillierte Darstellung der administrativen Vorbereitung seiner Expedition in der spanischen Hauptstadt und die im Rahmen dieses Prozesses erstellten Dokumente. Im Anhang werden zwei dieser bislang wenig bekannten Dokumente gezeigt: Das von Humboldt verfasste und beim spanischen König Karl IV abgegebene Schriftstück zur Erläuterung seines Anliegens sowie ein von Mariano Luis de Urquijo unterzeichneter Reisepass. KW - 1799 KW - Politik KW - Reisepass KW - Spanien Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41696 SN - 1617-5239 SN - 2568-3543 VL - VIII IS - 15 SP - 33 EP - 47 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Über die Autoren Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-42902 SN - 1617-5239 SN - 2568-3543 VL - X IS - 19 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Über die Autoren Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-42600 SN - 1617-5239 SN - 2568-3543 VL - X IS - 18 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR T1 - Hinweis auf die elektronischen Ressourcen, bereitgestellt von der Alexander-von-Humboldt-Forschungsstelle der Berlin-Brandenburgischen Akademie der Wissenschaften Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-42495 SN - 1617-5239 SN - 2568-3543 VL - IX EP - 17 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Börnert-Ringleb, Moritz A1 - Westphal, Andrea A1 - Zaruba, Nicole A1 - Gutmann, Franziska A1 - Vock, Miriam T1 - The relationship between attitudes toward inclusion, beliefs about teaching and learning, and subsequent automatic evaluations amongst student teachers JF - Frontiers in education N2 - Teachers' attitudes toward inclusion are frequently cited as being an important predictor of how successfully a given inclusive school system is implemented. At the same time, beliefs about the nature of teaching and learning are discussed as a possible predictor of attitudes toward inclusion. However, more recent research emphasizes the need of considering implicit processes, such as automatic evaluations, when describing attitudes and beliefs. Previous evidence on the association of attitudes toward inclusion and beliefs about teaching and learning is solely based on explicit reports. Therefore, this study aims to examine the relationship between attitudes toward inclusion, beliefs about teaching and learning, and the subsequent automatic evaluations of pre-service teachers (N = 197). The results revealed differences between pre-service teachers' explicit attitudes/beliefs and their subsequent automatic evaluations. Differences in the relationship between attitudes toward inclusion and beliefs about teaching and learning occur when teachers focus either on explicit measures or automatic evaluations. These differences might be due to different facets of the same attitude object being represented. Relying solely on either explicit measures or automatic evaluations at the exclusion of the other might lead to erroneous assumptions about the relation of attitudes toward inclusion and beliefs about teaching and learning. KW - inclusion KW - attitudes KW - teaching KW - automatic evaluation KW - beliefs KW - implicit Y1 - 2020 U6 - https://doi.org/10.3389/feduc.2020.584464 SN - 2504-284X VL - 5 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Zoll, Felix A1 - Diehl, Katharina A1 - Siebert, Rosemarie T1 - Integrating sustainability goals in innovation processes BT - applying a decision support tool in a dual-purpose chicken case study JF - Sustainability N2 - The innovative dual-purpose chicken approach aims at contributing to the transition towards sustainable poultry production by avoiding the culling of male chickens. To successfully integrate sustainability aspects into innovation, goal congruency among actors and clearly communicating the added value within the actor network and to consumers is needed. The challenge of identifying common sustainability goals calls for decision support tools. The objectives of our research were to investigate whether the tool could assist in improving communication and marketing with respect to sustainability and optimizing the value chain organization. Three actor groups participated in the tool application, in which quantitative and qualitative data were collected. The results showed that there were manifold sustainability goals within the innovation network, but only some goals overlapped, and the perception of their implementation also diverged. While easily marketable goals such as ‘animal welfare’ were perceived as being largely implemented, economic goals were prioritized less often, and the implementation was perceived as being rather low. By visualizing congruencies and differences in the goals, the tool helped identify fields of action, such as improved information flows and prompted thinking processes. We conclude that the tool is useful for managing complex decision processes with several actors involved. KW - value-based sustainability assessment KW - stakeholder participation KW - niche level KW - culling of male chickens KW - mixed methods Y1 - 2019 U6 - https://doi.org/10.3390/su11143761 SN - 2071-1050 VL - 11 IS - 14 PB - MDPI CY - Basel ER - TY - JOUR A1 - Brinkmann, Pia A1 - Köllner, Nicole A1 - Merk, Sven A1 - Beitz, Toralf A1 - Altenberger, Uwe A1 - Löhmannsröben, Hans-Gerd T1 - Comparison of handheld and echelle spectrometer to assess copper in ores by means of laser-induced breakdown spectroscopy (LIBS) JF - Minerals N2 - Its properties make copper one of the world’s most important functional metals. Numerous megatrends are increasing the demand for copper. This requires the prospection and exploration of new deposits, as well as the monitoring of copper quality in the various production steps. A promising technique to perform these tasks is Laser Induced Breakdown Spectroscopy (LIBS). Its unique feature, among others, is the ability to measure on site without sample collection and preparation. In this work, copper-bearing minerals from two different deposits are studied. The first set of field samples come from a volcanogenic massive sulfide (VMS) deposit, the second part from a stratiform sedimentary copper (SSC) deposit. Different approaches are used to analyze the data. First, univariate regression (UVR) is used. However, due to the strong influence of matrix effects, this is not suitable for the quantitative analysis of copper grades. Second, the multivariate method of partial least squares regression (PLSR) is used, which is more suitable for quantification. In addition, the effects of the surrounding matrices on the LIBS data are characterized by principal component analysis (PCA), alternative regression methods to PLSR are tested and the PLSR calibration is validated using field samples. KW - LIBS KW - copper-bearing minerals KW - UVR KW - PCA KW - PLSR Y1 - 2023 U6 - https://doi.org/10.3390/min13010113 SN - 2075-163X VL - 13 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Vidal-Garcia, Marta A1 - Bandara, Lashi A1 - Keogh, J. Scott T1 - ShapeRotator BT - an R tool for standardized rigid rotations of articulated three-dimensional structures with application for geometric morphometrics JF - Ecology and evolution N2 - The quantification of complex morphological patterns typically involves comprehensive shape and size analyses, usually obtained by gathering morphological data from all the structures that capture the phenotypic diversity of an organism or object. Articulated structures are a critical component of overall phenotypic diversity, but data gathered from these structures are difficult to incorporate into modern analyses because of the complexities associated with jointly quantifying 3D shape in multiple structures. While there are existing methods for analyzing shape variation in articulated structures in two-dimensional (2D) space, these methods do not work in 3D, a rapidly growing area of capability and research. Here, we describe a simple geometric rigid rotation approach that removes the effect of random translation and rotation, enabling the morphological analysis of 3D articulated structures. Our method is based on Cartesian coordinates in 3D space, so it can be applied to any morphometric problem that also uses 3D coordinates (e.g., spherical harmonics). We demonstrate the method by applying it to a landmark-based dataset for analyzing shape variation using geometric morphometrics. We have developed an R tool (ShapeRotator) so that the method can be easily implemented in the commonly used R package geomorph and MorphoJ software. This method will be a valuable tool for 3D morphological analyses in articulated structures by allowing an exhaustive examination of shape and size diversity. KW - articulation KW - morphology KW - motion correction KW - multi-modular morphology Y1 - 2018 U6 - https://doi.org/10.1002/ece3.4018 SN - 2045-7758 VL - 8 IS - 9 SP - 4669 EP - 4675 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Scheibel, Willy A1 - Trapp, Matthias A1 - Limberger, Daniel A1 - Döllner, Jürgen Roland Friedrich T1 - A taxonomy of treemap visualization techniques JF - Science and Technology Publications N2 - A treemap is a visualization that has been specifically designed to facilitate the exploration of tree-structured data and, more general, hierarchically structured data. The family of visualization techniques that use a visual metaphor for parent-child relationships based “on the property of containment” (Johnson, 1993) is commonly referred to as treemaps. However, as the number of variations of treemaps grows, it becomes increasingly important to distinguish clearly between techniques and their specific characteristics. This paper proposes to discern between Space-filling Treemap TS, Containment Treemap TC, Implicit Edge Representation Tree TIE, and Mapped Tree TMT for classification of hierarchy visualization techniques and highlights their respective properties. This taxonomy is created as a hyponymy, i.e., its classes have an is-a relationship to one another: TS TC TIE TMT. With this proposal, we intend to stimulate a discussion on a more unambiguous classification of treemaps and, furthermore, broaden what is understood by the concept of treemap itself. KW - Treemaps KW - Taxonomy Y1 - 2020 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hudson, Paul A1 - Hagedoorn, Liselotte A1 - Bubeck, Philip T1 - Potential linkages between social capital, flood risk perceptions, and self-efficacy JF - International journal of disaster risk science N2 - A growing focus is being placed on both individuals and communities to adapt to flooding as part of the Sendai Framework for Disaster Risk Reduction 2015-2030. Adaptation to flooding requires sufficient social capital (linkages between members of society), risk perceptions (understanding of risk), and self-efficacy (self-perceived ability to limit disaster impacts) to be effective. However, there is limited understanding of how social capital, risk perceptions, and self-efficacy interact. We seek to explore how social capital interacts with variables known to increase the likelihood of successful adaptation. To study these linkages we analyze survey data of 1010 respondents across two communities in Thua Tien-Hue Province in central Vietnam, using ordered probit models. We find positive correlations between social capital, risk perceptions, and self-efficacy overall. This is a partly contrary finding to what was found in previous studies linking these concepts in Europe, which may be a result from the difference in risk context. The absence of an overall negative exchange between these factors has positive implications for proactive flood risk adaptation. KW - flood risk KW - protection motivation theory KW - risk perceptions KW - social KW - capital KW - self-efficacy KW - Vietnam Y1 - 2020 U6 - https://doi.org/10.1007/s13753-020-00259-w SN - 2095-0055 SN - 2192-6395 VL - 11 IS - 3 SP - 251 EP - 262 PB - Springer CY - Berlin ER - TY - JOUR A1 - Banerjee, Pallavi A1 - Lipowsky, Reinhard A1 - Santer, Mark T1 - Coarse-grained molecular model for the Glycosylphosphatidylinositol anchor with and without protein JF - Journal of Chemical Theory and Computation N2 - Glycosylphosphatidylinositol (GPI) anchors are a unique class of complex glycolipids that anchor a great variety of proteins to the extracellular leaflet of plasma membranes of eukaryotic cells. These anchors can exist either with or without an attached protein called GPI-anchored protein (GPI-AP) both in vitro and in vivo. Although GPIs are known to participate in a broad range of cellular functions, it is to a large extent unknown how these are related to GPI structure and composition. Their conformational flexibility and microheterogeneity make it difficult to study them experimentally. Simplified atomistic models are amenable to all-atom computer simulations in small lipid bilayer patches but not suitable for studying their partitioning and trafficking in complex and heterogeneous membranes. Here, we present a coarse-grained model of the GPI anchor constructed with a modified version of the MARTINI force field that is suited for modeling carbohydrates, proteins, and lipids in an aqueous environment using MARTINI's polarizable water. The nonbonded interactions for sugars were reparametrized by calculating their partitioning free energies between polar and apolar phases. In addition, sugar-sugar interactions were optimized by adjusting the second virial coefficients of osmotic pressures for solutions of glucose, sucrose, and trehalose to match with experimental data. With respect to the conformational dynamics of GPI-anchored green fluorescent protein, the accessible time scales are now at least an order of magnitude larger than for the all-atom system. This is particularly important for fine-tuning the mutual interactions of lipids, carbohydrates, and amino acids when comparing to experimental results. We discuss the prospective use of the coarse-grained GPI model for studying protein-sorting and trafficking in membrane models. KW - Martini force-field KW - osmotic-pressure KW - potential-functions KW - aqueous-solution KW - dynamics KW - coefficient KW - simulation KW - trypanosoma KW - transition KW - parameters Y1 - 2020 U6 - https://doi.org/10.1021/acs.jctc.0c00056 SN - 1549-9626 SN - 1549-9618 VL - 16 IS - 6 PB - ACS Publications CY - Washington DC ER - TY - JOUR A1 - Hartung, Niklas A1 - Borghardt, Jens Markus T1 - A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs JF - PLoS Computational Biology : a new community journal N2 - Author summary
The use of orally inhaled drugs for treating lung diseases is appealing since they have the potential for lung selectivity, i.e. high exposure at the site of action -the lung- without excessive side effects. However, the degree of lung selectivity depends on a large number of factors, including physiochemical properties of drug molecules, patient disease state, and inhalation devices. To predict the impact of these factors on drug exposure and thereby to understand the characteristics of an optimal drug for inhalation, we develop a predictive mathematical framework (a "pharmacokinetic model"). In contrast to previous approaches, our model allows combining knowledge from different sources appropriately and its predictions were able to adequately predict different sets of clinical data. Finally, we compare the impact of different factors and find that the most important factors are the size of the inhaled particles, the affinity of the drug to the lung tissue, as well as the rate of drug dissolution in the lung. In contrast to the common belief, the solubility of a drug in the lining fluids is not found to be relevant. These findings are important to understand how inhaled drugs should be designed to achieve best treatment results in patients.
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Even though each single process has been systematically investigated, a quantitative understanding on the interaction of processes remains limited and therefore identifying optimal drug and formulation characteristics for orally inhaled drugs is still challenging. To investigate this complex interplay, the pulmonary processes can be integrated into mathematical models. However, existing modeling attempts considerably simplify these processes or are not systematically evaluated against (clinical) data. In this work, we developed a mathematical framework based on physiologically-structured population equations to integrate all relevant pulmonary processes mechanistically. A tailored numerical resolution strategy was chosen and the mechanistic model was evaluated systematically against data from different clinical studies. Without adapting the mechanistic model or estimating kinetic parameters based on individual study data, the developed model was able to predict simultaneously (i) lung retention profiles of inhaled insoluble particles, (ii) particle size-dependent pharmacokinetics of inhaled monodisperse particles, (iii) pharmacokinetic differences between inhaled fluticasone propionate and budesonide, as well as (iv) pharmacokinetic differences between healthy volunteers and asthmatic patients. Finally, to identify the most impactful optimization criteria for orally inhaled drugs, the developed mechanistic model was applied to investigate the impact of input parameters on both the pulmonary and systemic exposure. Interestingly, the solubility of the inhaled drug did not have any relevant impact on the local and systemic pharmacokinetics. Instead, the pulmonary dissolution rate, the particle size, the tissue affinity, and the systemic clearance were the most impactful potential optimization parameters. In the future, the developed prediction framework should be considered a powerful tool for identifying optimal drug and formulation characteristics. Y1 - 2020 U6 - https://doi.org/10.1371/journal.pcbi.1008466 SN - 1553-734X SN - 1553-7358 VL - 16 IS - 12 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Canitz, Julia A1 - Kirschbaum, Frank A1 - Tiedemann, Ralph T1 - Transcriptome-wide single nucleotide polymorphisms related to electric organ discharge differentiation among African weakly electric fish species JF - PLoS one N2 - African weakly electric fish of the mormyrid genus Campylomormyrus generate pulse-type electric organ discharges (EODs) for orientation and communication. Their pulse durations are species-specific and elongated EODs are a derived trait. So far, differential gene expression among tissue-specific transcriptomes across species with different pulses and point mutations in single ion channel genes indicate a relation of pulse duration and electrocyte geometry/excitability. However, a comprehensive assessment of expressed Single Nucleotide Polymorphisms (SNPs) throughout the entire transcriptome of African weakly electric fish, with the potential to identify further genes influencing EOD duration, is still lacking. This is of particular value, as discharge duration is likely based on multiple cellular mechanisms and various genes. Here we provide the first transcriptome-wide SNP analysis of African weakly electric fish species (genus Campylomormyrus) differing by EOD duration to identify candidate genes and cellular mechanisms potentially involved in the determination of an elongated discharge of C. tshokwe. Non-synonymous substitutions specific to C. tshokwe were found in 27 candidate genes with inferred positive selection among Campylomormyrus species. These candidate genes had mainly functions linked to transcriptional regulation, cell proliferation and cell differentiation. Further, by comparing gene annotations between C. compressirostris (ancestral short EOD) and C. tshokwe (derived elongated EOD), we identified 27 GO terms and 2 KEGG pathway categories for which C. tshokwe significantly more frequently exhibited a species-specific expressed substitution than C. compressirostris. The results indicate that transcriptional regulation as well cell proliferation and differentiation take part in the determination of elongated pulse durations in C. tshokwe. Those cellular processes are pivotal for tissue morphogenesis and might determine the shape of electric organs supporting the observed correlation between electrocyte geometry/tissue structure and discharge duration. The inferred expressed SNPs and their functional implications are a valuable resource for future investigations on EOD durations. Y1 - 2020 U6 - https://doi.org/10.1371/journal.pone.0240812 SN - 1932-6203 VL - 15 IS - 10 PB - PLoS CY - San Francisco, California, US ER - TY - JOUR A1 - Wiebking, Christine A1 - Lin, Chiao-I A1 - Wippert, Pia-Maria T1 - Training intervention effects on cognitive performance and neuronal plasticity — A pilot study JF - Frontiers in Neurology, section Neurorehabilitation N2 - Studies suggest that people suffering from chronic pain may have altered brain plasticity, along with altered functional connectivity between pain-processing brain regions. These may be related to decreased mood and cognitive performance. There is some debate as to whether physical activity combined with behavioral therapy (e.g. cognitive distraction, body scan) may counteract these changes. However, underlying neuronal mechanisms are unclear. The aim of the current pilot study with a 3-armed randomized controlled trial design was to examine the effects of sensorimotor training for nonspecific chronic low back pain on (1) cognitive performance; (2) fMRI activity co-fluctuations (functional connectivity) between pain-related brain regions; and (3) the relationship between functional connectivity and subjective variables (pain and depression). Six hundred and sixty two volunteers with non-specific chronic low back pain were randomly allocated to a unimodal (sensorimotor training), multidisciplinary (sensorimotor training and behavioral therapy) intervention, or to a control group within a multicenter study. A subsample of patients (n = 21) from one study center participated in the pilot study presented here. Measurements were at baseline, during (3 weeks, M2) and after intervention (12 weeks, M4 and 24 weeks, M5). Cognitive performance was measured by the Trail Making Test and functional connectivity by MRI. Pain perception and depression were assessed by the Von Korff questionnaire and the Hospital and Anxiety. Group differences were calculated by univariate and repeated ANOVA measures and Bayesian statistics; correlations by Pearson's r. Change and correlation of functional connection were analyzed within a pooled intervention group (uni-, multidisciplinary group). Results revealed that participants with increased pain intensity at baseline showed higher functional connectivity between pain-related brain areas used as ROIs in this study. Though small sample sizes limit generalization, cognitive performance increased in the multimodal group. Increased functional connectivity was observed in participants with increased pain ratings. Pain ratings and connectivity in pain-related brain regions decreased after the intervention. The results provide preliminary indication that intervention effects can potentially be achieved on the cognitive and neuronal level. The intervention may be suitable for therapy and prevention of non-specific chronic low back pain. KW - chronic back pain KW - sensorimotor training intervention KW - multimodal intervention KW - MRI KW - neuroplasticity Y1 - 2022 U6 - https://doi.org/10.3389/fneur.2022.773813 SN - 1664-2295 VL - 13 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Block, Andrea A1 - Bonaventura, Klaus A1 - Grahn, Patricia A1 - Bestgen, Felix A1 - Wippert, Pia-Maria T1 - Stress management in pre-and postoperative care amongst practitioners and patients in cardiac catheterization laboratory: a study protocol JF - Frontiers in Cardiovascular Medicine N2 - Background: As the number of cardiac diseases continuously increases within the last years in modern society, so does cardiac treatment, especially cardiac catheterization. The procedure of a cardiac catheterization is challenging for both patients and practitioners. Several potential stressors of psychological or physical nature can occur during the procedure. The objective of the study is to develop and implement a stress management intervention for both practitioners and patients that aims to reduce the psychological and physical strain of a cardiac catheterization. Methods: The clinical study (DRKS00026624) includes two randomized controlled intervention trials with parallel groups, for patients with elective cardiac catheterization and practitioners at the catheterization lab, in two clinic sites of the Ernst-von-Bergmann clinic network in Brandenburg, Germany. Both groups received different interventions for stress management. The intervention for patients comprises a psychoeducational video with different stress management technics and additional a standardized medical information about the cardiac catheterization examination. The control condition includes the in hospitals practiced medical patient education before the examination (usual care). Primary and secondary outcomes are measured by physiological parameters and validated questionnaires, the day before (M1) and after (M2) the cardiac catheterization and at a postal follow-up 6 months later (M3). It is expected that people with standardized information and psychoeducation show reduced complications during cardiac catheterization procedures, better pre- and post-operative wellbeing, regeneration, mood and lower stress levels over time. The intervention for practitioners includes a Mindfulness-based stress reduction program (MBSR) over 8 weeks supervised by an experienced MBSR practitioner directly at the clinic site and an operative guideline. It is expected that practitioners with intervention show improved perceived and chronic stress, occupational health, physical and mental function, higher effort-reward balance, regeneration and quality of life. Primary and secondary outcomes are measured by physiological parameters (heart rate variability, saliva cortisol) and validated questionnaires and will be assessed before (M1) and after (M2) the MBSR intervention and at a postal follow-up 6 months later (M3). Physiological biomarkers in practitioners will be assessed before (M1) and after intervention (M2) on two work days and a two days off. Intervention effects in both groups (practitioners and patients) will be evaluated separately using multivariate variance analysis. Discussion: This study evaluates the effectiveness of two stress management intervention programs for patients and practitioners within cardiac catheter laboratory. Study will disclose strains during a cardiac catheterization affecting both patients and practitioners. For practitioners it may contribute to improved working conditions and occupational safety, preservation of earning capacity, avoidance of participation restrictions and loss of performance. In both groups less anxiety, stress and complications before and during the procedures can be expected. The study may add knowledge how to eliminate stressful exposures and to contribute to more (psychological) security, less output losses and exhaustion during work. The evolved stress management guidelines, training manuals and the standardized patient education should be transferred into clinical routines KW - stress management KW - mindfulness-based stress reduction KW - psychoeducation KW - standardized patient information KW - stress intervention KW - distress KW - study protocol KW - cardiac catheterization (CC) Y1 - 2022 U6 - https://doi.org/10.3389/fcvm.2022.830256 SN - 2297-055X VL - 9 SP - 1 EP - 10 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Ellermann, Christin A1 - McDowell, Michelle A1 - Schirren, Clara O. A1 - Lindemann, Ann-Kathrin A1 - Koch, Severine A1 - Lohmann, Mark A1 - Jenny, Mirjam Annina T1 - Identifying content to improve risk assessment communications within the Risk Profile: Literature reviews and focus groups with expert and non-expert stakeholders JF - PLoS ONE N2 - Objective To improve consumer decision making, the results of risk assessments on food, feed, consumer products or chemicals need to be communicated not only to experts but also to non-expert audiences. The present study draws on evidence from literature reviews and focus groups with diverse stakeholders to identify content to integrate into an existing risk assessment communication (Risk Profile). Methods A combination of rapid literature reviews and focus groups with experts (risk assessors (n = 15), risk managers (n = 8)), and non-experts (general public (n = 18)) were used to identify content and strategies for including information about risk assessment results in the “Risk Profile” from the German Federal Institute for Risk Assessment. Feedback from initial focus groups was used to develop communication prototypes that informed subsequent feedback rounds in an iterative process. A final prototype was validated in usability tests with experts. Results Focus group feedback and suggestions from risk assessors were largely in line with findings from the literature. Risk managers and lay persons offered similar suggestions on how to improve the existing communication of risk assessment results (e.g., including more explanatory detail, reporting probabilities for individual health impairments, and specifying risks for subgroups in additional sections). Risk managers found information about quality of evidence important to communicate, whereas people from the general public found this information less relevant. Participants from lower educational backgrounds had difficulties understanding the purpose of risk assessments. User tests found that the final prototype was appropriate and feasible to implement by risk assessors. Conclusion An iterative and evidence-based process was used to develop content to improve the communication of risk assessments to the general public while being feasible to use by risk assessors. Remaining challenges include how to communicate dose-response relationships and standardise quality of evidence ratings across disciplines. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0266800 SN - 1553-7358 VL - 17 PB - Public Library of Science (PLOS) CY - San Francisco, California, USA ET - 4 ER - TY - JOUR A1 - Osei, Francis A1 - Block, Andrea A1 - Wippert, Pia-Maria T1 - Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review JF - Frontiers in Endocrinology N2 - Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS. KW - allostatic load KW - cortisol KW - dehydroepiandrosterone sulfate KW - epinephrine KW - norepinephrine KW - metabolic syndrome KW - primary marker Y1 - 2022 U6 - https://doi.org/10.3389/fendo.2022.946740 SN - 1664-2392 VL - 13 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Kolyvushko, Oleksandr A1 - Latzke, Juliane A1 - Dahmani, Ismail A1 - Osterrieder, Nikolaus A1 - Chiantia, Salvatore A1 - Azab, Walid T1 - Differentially-charged liposomes interact with alphaherpesviruses and interfere with virus entry JF - Pathogens N2 - Exposure of phosphatidylserine (PS) in the outer leaflet of the plasma membrane is induced by infection with several members of the Alphaherpesvirinae subfamily. There is evidence that PS is used by the equine herpesvirus type 1 (EHV-1) during entry, but the exact role of PS and other phospholipids in the entry process remains unknown. Here, we investigated the interaction of differently charged phospholipids with virus particles and determined their influence on infection. Our data show that liposomes containing negatively charged PS or positively charged DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium) inhibited EHV-1 infection, while neutral phosphatidylcholine (PC) had no effect. Inhibition of infection with PS was transient, decreased with time, and was dose dependent. Our findings indicate that both cationic and anionic phospholipids can interact with the virus and reduce infectivity, while, presumably, acting through different mechanisms. Charged phospholipids were found to have antiviral effects and may be used to inhibit EHV-1 infection. KW - alphaherpesvirus KW - EHV-1 KW - phosphatidylserine KW - inhibition KW - pathogen host KW - interaction Y1 - 2020 U6 - https://doi.org/10.3390/pathogens9050359 SN - 2076-0817 VL - 9 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Seržant, Ilja A. A1 - Moroz, George A. T1 - Universal attractors in language evolution provide evidence for the kinds of efficiency pressures involved JF - Humanities & Social Sciences Communications N2 - Efficiency is central to understanding the communicative and cognitive underpinnings of language. However, efficiency management is a complex mechanism in which different efficiency effects-such as articulatory, processing and planning ease, mental accessibility, and informativity, online and offline efficiency effects-conspire to yield the coding of linguistic signs. While we do not yet exactly understand the interactional mechanism of these different effects, we argue that universal attractors are an important component of any dynamic theory of efficiency that would be aimed at predicting efficiency effects across languages. Attractors are defined as universal states around which language evolution revolves. Methodologically, we approach efficiency from a cross-linguistic perspective on the basis of a world-wide sample of 383 languages from 53 families, balancing all six macro-areas (Eurasia, North and South America, Australia, Africa, and Oceania). We explore the grammatical domain of verbal person-number subject indexes. We claim that there is an attractor state in this domain to which languages tend to develop and tend not to leave if they happen to comply with the attractor in their earlier stages of evolution. The attractor is characterized by different lengths for each person and number combination, structured along Zipf's predictions. Moreover, the attractor strongly prefers non-compositional, cumulative coding of person and number. On the basis of these and other properties of the attractor, we conclude that there are two domains in which efficiency pressures are most powerful: strive towards less processing and articulatory effort. The latter, however, is overridden by constant information flow. Strive towards lower lexicon complexity and memory costs are weaker efficiency pressures for this grammatical category due to its order of frequency. KW - Duration KW - Explanations KW - Redundancy KW - Pronouns KW - Usage Y1 - 2022 U6 - https://doi.org/10.1057/s41599-022-01072-0 SN - 2662-9992 VL - 9 IS - 1 PB - Springer Nature CY - London ER - TY - JOUR A1 - Fliesser, Michael A1 - De Witt Huberts, Jessie A1 - Wippert, Pia-Maria T1 - The choice that matters: the relative influence of socioeconomic status indicators on chronic back pain- a longitudinal study JF - BMC health services research N2 - Background: In health research, indicators of socioeconomic status (SES) are often used interchangeably and often lack theoretical foundation. This makes it difficult to compare results from different studies and to explore the relationship between SES and health outcomes. To aid researchers in choosing appropriate indicators of SES, this article proposes and tests a theory-based selection of SES indicators using chronic back pain as a health outcome. Results: Chronic back pain intensity was best predicted by the multidimensional index (beta = 0.31, p < 0.05), followed by job position (beta = 0.29, p < 0.05) and education (beta = -0.29, p < 0.05); whereas, income exerted no significant influence. Back pain disability was predicted strongest by education (beta = -0.30, p < 0.05) and job position (beta = 0. 29, p < 0.05). Here, multidimensional index and income had no significant influence. Conclusions: The choice of SES indicators influences predictive power on both back pain dimensions, suggesting SES predictors cannot be used interchangeably. Therefore, researchers should carefully consider prior to each study which SES indicator to use. The introduced framework can be valuable in supporting this decision because it allows for a stable prediction of SES indicator influence and their hierarchy on a specific health outcomes. KW - socioeconomic status KW - Indicators of socioeconomic status KW - health inequality KW - education KW - job position KW - income KW - chronic back pain Y1 - 2017 U6 - https://doi.org/10.1186/s12913-017-2735-9 SN - 1472-6963 VL - 17 PB - BioMed Central CY - London ER - TY - JOUR A1 - Starzonek, Janine A1 - Roscher, Katja A1 - Blither, Matthias A1 - Blaue, Dominique A1 - Schedlbauer, Carola A1 - Hire, Manuela A1 - Raila, Jens A1 - Vervuert, Ingrid T1 - Effects of a blend of green tea and curcuma extract supplementation on lipopolysaccharide-induced inflammation in horses and ponies JF - PeerJ N2 - Background. In horses and ponies numerous medical conditions are known to be linked with inflammation in different tissues, especially in the liver. Besides affecting other metabolic pathways such as the expression of certain interleukins (IL), inflammation is associated with stress of the endoplasmic reticulum (ER). In particular, ER stress leads to adaptive stress response and can be measured by several markers of inflammatory and stress signalling pathways, like nuclear factor kappa B (NF-kB). Objectives. To investigate lipopolysaccharide (LPS)-induced inflammatory reactions and their modulation in horses and ponies by feeding a polyphenol-rich supplement consisting of green tea and curcuma. Methods. In a cross-over study, 11 animals were allocated to either a placebo or a supplement group and supplemented with 10 g of a blend of green tea and curcuma extract (GCE) or a placebo (calcium carbonate) once daily. After 21 days of supplementation, all animals underwent a LPS challenge to induce moderate systemic inflammation. Blood samples and liver biopsies were taken at standardized time points: 24 hours before and 12 hours after LPS challenge. Inflammatory blood parameters such as serum amyloid A (SAA), haptoglobin and retinol binding protein 4 (RBP4) were measured in serum. Hepatic mRNA levels of selected markers of inflammation such as haptoglobin, tumor necrosis factor alpha (TNF-alpha), IL-1 beta, IL-6, cluster of differentiation 68 (CD68), fibroblast growth factor 21 (FGF-21), NF-kappa B, activating transcription factor 4 (ATF4) were quantified by RT-qPCR. In addition, liver biopsies were examined histologically for inflammatory alterations. Results. Blood markers of acute inflammatory response increased after LPS challenge. In the liver, the proinflammatory cytokine IL-1 beta showed significantly lower mRNA levels after LPS challenge in the supplemented group (P = 0.04) compared to the placebo group. Levels of the hepatic CD68 mRNA increased significantly in the placebo group (P = 0.04). There were no significant differences between supplemented and placebo groups concerning other markers of inflammation and markers of ER stress within the liver. The number of hepatic macrophages were not different after LPS challenge in both feeding groups. Conclusion. LPS was able to induce inflammation but seemed less suitable to induce ER stress in the horses and ponies. The polyphenol-rich supplement showed some potential to reduce inflammatory responses. Nevertheless, the supplementation did not exert an overall anti-inflammatory effect in horses and ponies. KW - Curcumin KW - Catechin KW - Equines KW - ER-stress KW - Polyphenols Y1 - 2019 U6 - https://doi.org/10.7717/peerj.8053 SN - 2167-8359 VL - 7 PB - PeerJ Inc. CY - London ER - TY - JOUR A1 - Tutu, Anthony Osei A1 - Steinberger, Bernhard A1 - Sobolev, Stephan Vladimir A1 - Rogozhina, Irina A1 - Popov, Anton A. T1 - Effects of upper mantle heterogeneities on the lithospheric stress field and dynamic topography JF - Solid earth N2 - The orientation and tectonic regime of the observed crustal/lithospheric stress field contribute to our knowledge of different deformation processes occurring within the Earth's crust and lithosphere. In this study, we analyze the influence of the thermal and density structure of the upper mantle on the lithospheric stress field and topography. We use a 3-D lithosphere–asthenosphere numerical model with power-law rheology, coupled to a spectral mantle flow code at 300 km depth. Our results are validated against the World Stress Map 2016 (WSM2016) and the observation-based residual topography. We derive the upper mantle thermal structure from either a heat flow model combined with a seafloor age model (TM1) or a global S-wave velocity model (TM2). We show that lateral density heterogeneities in the upper 300 km have a limited influence on the modeled horizontal stress field as opposed to the resulting dynamic topography that appears more sensitive to such heterogeneities. The modeled stress field directions, using only the mantle heterogeneities below 300 km, are not perturbed much when the effects of lithosphere and crust above 300 km are added. In contrast, modeled stress magnitudes and dynamic topography are to a greater extent controlled by the upper mantle density structure. After correction for the chemical depletion of continents, the TM2 model leads to a much better fit with the observed residual topography giving a good correlation of 0.51 in continents, but this correction leads to no significant improvement of the fit between the WSM2016 and the resulting lithosphere stresses. In continental regions with abundant heat flow data, TM1 results in relatively small angular misfits. For example, in western Europe the misfit between the modeled and observation-based stress is 18.3°. Our findings emphasize that the relative contributions coming from shallow and deep mantle dynamic forces are quite different for the lithospheric stress field and dynamic topography. Y1 - 2018 U6 - https://doi.org/10.5194/se-9-649-2018 SN - 1869-9510 SN - 1869-9529 VL - 9 IS - 3 SP - 649 EP - 668 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Tchewonpi Sagu, Sorel A1 - Landgräber, Eva A1 - Henkel, Ina M. A1 - Huschek, Gerd A1 - Homann, Thomas A1 - Bußler, Sara A1 - Schlüter, Oliver K. A1 - Rawel, Harshadrai Manilal T1 - Effect of cereal α-amylase/trypsin inhibitors on developmental characteristics and abundance of digestive enzymes of mealworm larvae (Tenebrio molitor L.) JF - Insects N2 - The objective of this work was to investigate the potential effect of cereal α-amylase/trypsin inhibitors (ATIs) on growth parameters and selective digestive enzymes of Tenebrio molitor L. larvae. The approach consisted of feeding the larvae with wheat, sorghum and rice meals containing different levels and composition of α-amylase/trypsin inhibitors. The developmental and biochemical characteristics of the larvae were assessed over feeding periods of 5 h, 5 days and 10 days, and the relative abundance of α-amylase and selected proteases in larvae were determined using liquid chromatography tandem mass spectrometry. Overall, weight gains ranged from 21% to 42% after five days of feeding. The larval death rate significantly increased in all groups after 10 days of feeding (p < 0.05), whereas the pupation rate was about 25% among larvae fed with rice (Oryza sativa L.) and Siyazan/Esperya wheat meals, and only 8% and 14% among those fed with Damougari and S35 sorghum meals. As determined using the Lowry method, the protein contents of the sodium phosphate extracts ranged from 7.80 ± 0.09 to 9.42 ± 0.19 mg/mL and those of the ammonium bicarbonate/urea reached 19.78 ± 0.16 to 37.47 ± 1.38 mg/mL. The total protein contents of the larvae according to the Kjeldahl method ranged from 44.0 and 49.9 g/100 g. The relative abundance of α-amylase, CLIP domain-containing serine protease, modular serine protease zymogen and C1 family cathepsin significantly decreased in the larvae, whereas dipeptidylpeptidase I and chymotrypsin increased within the first hours after feeding (p < 0.05). Trypsin content was found to be constant independently of time or feed material. Finally, based on the results we obtained, it was difficult to substantively draw conclusions on the likely effects of meal ATI composition on larval developmental characteristics, but their effects on the digestive enzyme expression remain relevant. KW - growth behavior KW - Tenebrio molitor larvae KW - feeding KW - cereal meals KW - α-amylase/trypsin inhibitors KW - digestive enzymes quantification KW - LC-MS/MS Y1 - 2021 U6 - https://doi.org/10.3390/insects12050454 SN - 2075-4450 VL - 12 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Aloni, Sapir Shekef A1 - Perovic, Milena A1 - Weitman, Michal A1 - Cohen, Reut A1 - Oschatz, Martin A1 - Mastai, Yitzhak T1 - Amino acid-based ionic liquids as precursors for the synthesis of chiral nanoporous carbons JF - Nanoscale Advances N2 - The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces. Y1 - 2019 U6 - https://doi.org/10.1039/c9na00520j SN - 2516-0230 VL - 1 IS - 12 SP - 4981 EP - 4988 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Mendel, Ralf R. A1 - Hercher, Thomas W. A1 - Zupok, Arkadiusz A1 - Hasnat, Muhammad Abrar A1 - Leimkühler, Silke T1 - The requirement of inorganic Fe-S clusters for the biosynthesis of the organometallic molybdenum cofactor JF - Inorganics : open access journal N2 - Iron-sulfur (Fe-S) clusters are essential protein cofactors. In enzymes, they are present either in the rhombic [2Fe-2S] or the cubic [4Fe-4S] form, where they are involved in catalysis and electron transfer and in the biosynthesis of metal-containing prosthetic groups like the molybdenum cofactor (Moco). Here, we give an overview of the assembly of Fe-S clusters in bacteria and humans and present their connection to the Moco biosynthesis pathway. In all organisms, Fe-S cluster assembly starts with the abstraction of sulfur froml-cysteine and its transfer to a scaffold protein. After formation, Fe-S clusters are transferred to carrier proteins that insert them into recipient apo-proteins. In eukaryotes like humans and plants, Fe-S cluster assembly takes place both in mitochondria and in the cytosol. Both Moco biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. Moco is a tricyclic pterin compound with molybdenum coordinated through its unique dithiolene group. Moco biosynthesis begins in the mitochondria in a Fe-S cluster dependent step involving radical/S-adenosylmethionine (SAM) chemistry. An intermediate is transferred to the cytosol where the dithiolene group is formed, to which molybdenum is finally added. Further connections between Fe-S cluster assembly and Moco biosynthesis are discussed in detail. KW - Moco biosynthesis KW - Fe-S cluster assembly KW - l-cysteine desulfurase KW - ISC KW - SUF KW - NIF KW - iron KW - molybdenum KW - sulfur Y1 - 2020 U6 - https://doi.org/10.3390/inorganics8070043 SN - 2304-6740 VL - 8 IS - 7 PB - MDPI CY - Basel ER - TY - JOUR A1 - Potts, Jonathan R. A1 - Schlägel, Ulrike E. T1 - Parametrizing diffusion-taxis equations from animal movement trajectories using step selection analysis JF - Methods in ecology and evolution : an official journal of the British Ecological Society N2 - Mathematical analysis of partial differential equations (PDEs) has led to many insights regarding the effect of organism movements on spatial population dynamics. However, their use has mainly been confined to the community of mathematical biologists, with less attention from statistical and empirical ecologists. We conjecture that this is principally due to the inherent difficulties in fitting PDEs to data. To help remedy this situation, in the context of movement ecology, we show how the popular technique of step selection analysis (SSA) can be used to parametrize a class of PDEs, calleddiffusion-taxismodels, from an animal's trajectory. We examine the accuracy of our technique on simulated data, then demonstrate the utility of diffusion-taxis models in two ways. First, for non-interacting animals, we derive the steady-state utilization distribution in a closed analytic form. Second, we give a recipe for deriving spatial pattern formation properties that emerge from interacting animals: specifically, do those interactions cause heterogeneous spatial distributions to emerge and if so, do these distributions oscillate at short times or emerge without oscillations? The second question is applied to data on concurrently tracked bank volesMyodes glareolus. Our results show that SSA can accurately parametrize diffusion-taxis equations from location data, providing the frequency of the data is not too low. We show that the steady-state distribution of our diffusion-taxis model, where it is derived, has an identical functional form to the utilization distribution given by resource selection analysis (RSA), thus formally linking (fine scale) SSA with (broad scale) RSA. For the bank vole data, we show how our SSA-PDE approach can give predictions regarding the spatial aggregation and segregation of different individuals, which are difficult to predict purely by examining results of SSA. Our methods provide a user-friendly way into the world of PDEs, via a well-used statistical technique, which should lead to tighter links between the findings of mathematical ecology and observations from empirical ecology. By providing a non-speculative link between observed movement behaviours and space use patterns on larger spatio-temporal scales, our findings will also aid integration of movement ecology into understanding spatial species distributions. KW - advection-diffusion KW - animal movement KW - home range KW - movement ecology KW - partial differential equations KW - resource selection KW - step selection KW - taxis Y1 - 2020 U6 - https://doi.org/10.1111/2041-210X.13406 SN - 2041-210X VL - 11 IS - 9 SP - 1092 EP - 1105 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Levy, Jessica A1 - Mussack, Dominic A1 - Brunner, Martin A1 - Keller, Ulrich A1 - Cardoso-Leite, Pedro A1 - Fischbach, Antoine T1 - Contrasting classical and machine learning approaches in the estimation of value-added scores in large-scale educational data JF - Frontiers in psychology N2 - There is no consensus on which statistical model estimates school value-added (VA) most accurately. To date, the two most common statistical models used for the calculation of VA scores are two classical methods: linear regression and multilevel models. These models have the advantage of being relatively transparent and thus understandable for most researchers and practitioners. However, these statistical models are bound to certain assumptions (e.g., linearity) that might limit their prediction accuracy. Machine learning methods, which have yielded spectacular results in numerous fields, may be a valuable alternative to these classical models. Although big data is not new in general, it is relatively new in the realm of social sciences and education. New types of data require new data analytical approaches. Such techniques have already evolved in fields with a long tradition in crunching big data (e.g., gene technology). The objective of the present paper is to competently apply these "imported" techniques to education data, more precisely VA scores, and assess when and how they can extend or replace the classical psychometrics toolbox. The different models include linear and non-linear methods and extend classical models with the most commonly used machine learning methods (i.e., random forest, neural networks, support vector machines, and boosting). We used representative data of 3,026 students in 153 schools who took part in the standardized achievement tests of the Luxembourg School Monitoring Program in grades 1 and 3. Multilevel models outperformed classical linear and polynomial regressions, as well as different machine learning models. However, it could be observed that across all schools, school VA scores from different model types correlated highly. Yet, the percentage of disagreements as compared to multilevel models was not trivial and real-life implications for individual schools may still be dramatic depending on the model type used. Implications of these results and possible ethical concerns regarding the use of machine learning methods for decision-making in education are discussed. KW - value-added modeling KW - school effectiveness KW - machine learning KW - model KW - comparison KW - longitudinal data Y1 - 2020 U6 - https://doi.org/10.3389/fpsyg.2020.02190 SN - 1664-1078 VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER -