TY - JOUR A1 - Salzer, Leonhard A1 - Nöbauer, Anna ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - (Auf) Humboldts Spuren BT - eine bauforscherische Untersuchung der „Casa Humboldt“ am Antisana in Ecuador T2 - HiN : Alexander von Humboldt im Netz N2 - Vor seiner Besteigung des Antisana in Ecuador verbrachte Alexander von Humboldt mit seinem Expeditionsteam die Nacht vom 15. auf den 16. März 1802 in einer Hacienda am Fuße des Vulkangipfels, deren letztes bauliches Zeugnis eine steinerne Hütte darstellt. Bauforscherische Untersuchungen eines internationalen Forscherteams konnten die mehrschichtige Bau- und Reparaturgeschichte dieses Baudenkmals ermitteln und über eine Auswertung von Reiseberichten mehrerer Andenforscher die Nutzungsgeschichte des einzelnen Gebäudes und des gesamten Anwesens klären. Schließlich ergaben sich daraus neue Erkenntnisse zu Humboldts Aufenthalt am Antisana. N2 - Before climbing the Antisana in Ecuador, Alexander von Humboldt and his expedition team encamped at a hacienda at the foot of the volcano’s summit in the night from 15 to 16 March 1802. A stone hut is the only structural testimony of this estate that remains today. Through building archaeological investigations, an international team of researchers was able to determine the construction and restoration history of this monument. An evaluation of the descriptions of the hacienda in 19th- and early 20th-century travel accounts clarified the historical use of the estate and, in particular, the existing hut, thus shedding new light on Humboldt’s stay in 1802. N2 - Previamente a su ascensión del volcán Antisana en Ecuador, Alexander von Humboldt se hospedó la noche del 15 al 16 de marzo de 1802 en una hacienda al pie del volcán, juntamente con el equipo que le acompañaba en su expedición. Si bien el último atestado que se tenía de esta comprendía una cabaña de piedra, nuevas investigaciones sobre arqueología vertical por parte de un equipo de investigación internacional muestran una nueva historia de construcción y reparación de este monumento histórico. Con ello, se pretende, por una parte, valorar en detalle las crónicas de viaje de múltiples investigadores de los Andes, así como, por otra, esclarecer la historia constructiva y de utilización de la singular edifi cación así como su papel dentro de la propiedad en que se encuentra. A través de esta investigación aparecen nuevos conocimientos sobre la estancia de Humboldt en el Antisana. KW - Bauforschung KW - Ecuador KW - Antisana KW - Hacienda de Antisana Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-533271 SN - 2568-3543 SN - 1617-5239 VL - XXII IS - 43 SP - 65 EP - 82 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Macdonald, Elena A1 - Otero, Noelia A1 - Butler, Tim T1 - A comparison of long-term trends in observations and emission inventories of NOx JF - Atmospheric chemistry and physics / European Geosciences Union N2 - Air pollution is a pressing issue that is associated with adverse effects on human health, ecosystems, and climate. Despite many years of effort to improve air quality, nitrogen dioxide (NO2) limit values are still regularly exceeded in Europe, particularly in cities and along streets. This study explores how concentrations of nitrogen oxides (NOx = NO + NO2) in European urban areas have changed over the last decades and how this relates to changes in emissions. To do so, the incremental approach was used, comparing urban increments (i.e. urban background minus rural concentrations) to total emissions, and roadside increments (i.e. urban roadside concentrations minus urban background concentrations) to traffic emissions. In total, nine European cities were assessed. The study revealed that potentially confounding factors like the impact of urban pollution at rural monitoring sites through atmospheric transport are generally negligible for NOx. The approach proves therefore particularly useful for this pollutant. The estimated urban increments all showed downward trends, and for the majority of the cities the trends aligned well with the total emissions. However, it was found that factors like a very densely populated surrounding or local emission sources in the rural area such as shipping traffic on inland waterways restrict the application of the approach for some cities. The roadside increments showed an overall very diverse picture in their absolute values and trends and also in their relation to traffic emissions. This variability and the discrepancies between roadside increments and emissions could be attributed to a combination of local influencing factors at the street level and different aspects introducing inaccuracies to the trends of the emis-sion inventories used, including deficient emission factors. Applying the incremental approach was evaluated as useful for long-term pan-European studies, but at the same time it was found to be restricted to certain regions and cities due to data availability issues. The results also highlight that using emission inventories for the prediction of future health impacts and compliance with limit values needs to consider the distinct variability in the concentrations not only across but also within cities. Y1 - 2021 U6 - https://doi.org/10.5194/acp-21-4007-2021 SN - 1680-7316 SN - 1680-7324 VL - 21 IS - 5 SP - 4007 EP - 4023 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Wolff, Martin A1 - Gast, Klaus A1 - Evers, Andreas A1 - Kurz, Michael A1 - Pfeiffer-Marek, Stefania A1 - Schüler, Anja A1 - Seckler, Robert A1 - Thalhammer, Anja T1 - A Conserved Hydrophobic Moiety and Helix-Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4 JF - Biomolecules N2 - Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix–helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers. KW - biophysics KW - diabetes KW - peptides KW - oligomerization KW - conformational change KW - molecular modeling KW - static and dynamic light scattering KW - spectroscopy Y1 - 2021 U6 - https://doi.org/10.3390/biom11091305 SN - 2218-273X VL - 11 IS - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Ette, Ottmar T1 - A expulsão do Éden BT - Migração e escrita depois do paraíso JF - Literatura e autoritarismo N2 - A temática da migração está intimamente vinculada à história humana, desde a narrativa bíblica da expulsão do paraíso. O ser humano não apenas empregou técnicas cada vez mais sofisticadas para a violência, como também transmitiu, através dos séculos, técnicas de conservação e uso de seu saberconviver. Nesse sentido móvel da história, e em consonância com as literaturas do mundo, a partir de suas diversas origens, é possível dizer que existe um “Homo migrans” desde que existe o “Homo sapiens”. Assim, é possível afirmar que as ideias territoriais ou territorializantes com proveniência histórico-espacial permitem, vez ou outra, reconhecer seus esforços para filtrar e isolar a dimensão histórico-móvel e vetorial da história como narrativa, para tentar construir, com a ajuda de ideias estáticas, novos lugares da promessa ou da perda, da abundância ou da queda. KW - Migração KW - Saberconviver KW - Literaturas do mundo Y1 - 2021 U6 - https://doi.org/10.5902/1679849X65745 SN - 1679-849X IS - 25 SP - 5 EP - 42 PB - Universidade Federal de Santa Maria (UFSM) CY - Santa Maria ER - TY - JOUR A1 - Schwarz, Ingo A1 - Kutzinski, Vera M. ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - A Letter from Alexander von Humboldt to Joseph Albert Wright – Archival Traces JF - HiN : Alexander von Humboldt im Netz N2 - A few months before his death, A. v. Humboldt attended the celebration in honor of the 127th birthday of George Washington at the US legation in Berlin. A letter to the American Envoy, Joseph A. Wright (1810 – 1867), underlines Humboldt’s admiration for the fi rst president of the United States. At the same time Humboldt asked the diplomat to mail a letter to the German-American Bernard Moses (1832 – 1897) in Clinton, Louisiana, who had named his son Alexander Humboldt Moses (grave on the Hebrew Rest Cemetery #2 in New Orleans, burial plot A, 12, 5). It appears to be possible that the Moses family still owns Humboldt’s letter. N2 - Wenige Monate vor seinem Tod besuchte A. v. Humboldt die Feier zu Ehren des 127. Geburtstages von George Washington an der Gesandtschaft der Vereinigten Staaten in Berlin. Ein Brief an den Gesandten, Joseph A. Wright (1810 – 1867), betonte Humboldts Bewunderung für den ersten Präsidenten der Vereinten Staaten. Gleichzeit bat Humboldt den Diplomaten um die Beförderung eines Briefes an den Deutschamerikaner Bernard Moses(1832 – 1897) in Clinton, Louisiana, der seinen Sohn Alexander Humboldt Moses (Grab auf dem Hebrew Rest Cemetery #2 in New Orleans, Grabstelle A, 12, 5) genannt hat. N2 - Unos meses antes de su muerte, A. v. Humboldt asistió a la celebración en honor al 127º cumpleaños de George Washington en la legación estadounidense en Berlín. Una carta al delegado estadounidense, Joseph A. Wright (1810 – 1867), subraya la admiración de Humboldt por el primer presidente de los Estados Unidos. Al mismo tiempo, Humboldt le pidió al diplomático que enviara una carta al germano-estadounidense Bernard Moses (1832 – 1897) en Clinton, Louisiana, quien había puesto a su hijo, el nombre de Alexander Humboldt Moses(tumba en el cementerio Hebrew Rest número 2 en Nueva Orleans, lugar de enteramiento: A, 12, 5). KW - Alexander Humboldt KW - Moses KW - Korrespondenz Alexander von Humboldts KW - Vereinigten Staaten Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532787 SN - 2568-3543 SN - 1617-5239 VL - XXII IS - 43 SP - 5 EP - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Fuchs, Susanne A1 - Koenig, Laura L. A1 - Gerstenberg, Annette T1 - A longitudinal study of speech acoustics in older French females BT - analysis of the filler particle euh across utterance positions JF - Languages : open access journal N2 - Aging in speech production is a multidimensional process. Biological, cognitive, social, and communicative factors can change over time, stay relatively stable, or may even compensate for each other. In this longitudinal work, we focus on stability and change at the laryngeal and supralaryngeal levels in the discourse particle euh produced by 10 older French-speaking females at two times, 10 years apart. Recognizing the multiple discourse roles of euh, we divided out occurrences according to utterance position. We quantified the frequency of euh, and evaluated acoustic changes in formants, fundamental frequency, and voice quality across time and utterance position. Results showed that euh frequency was stable with age. The only acoustic measure that revealed an age effect was harmonics-to-noise ratio, showing less noise at older ages. Other measures mostly varied with utterance position, sometimes in interaction with age. Some voice quality changes could reflect laryngeal adjustments that provide for airflow conservation utterance-finally. The data suggest that aging effects may be evident in some prosodic positions (e.g., utterance-final position), but not others (utterance-initial position). Thus, it is essential to consider the interactions among these factors in future work and not assume that vocal aging is evident throughout the signal. KW - aging KW - prosody KW - voice quality KW - fundamental frequency KW - formants KW - filler KW - particles Y1 - 2021 U6 - https://doi.org/10.3390/languages6040211 SN - 2226-471X VL - 6 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Ramezani Ziarani, Maryam A1 - Bookhagen, Bodo A1 - Schmidt, Torsten A1 - Wickert, Jens A1 - de la Torre, Alejandro A1 - Deng, Zhiguo A1 - Calori, Andrea T1 - A model for the relationship between rainfall, GNSS-derived integrated water vapour, and CAPE in the eastern central Andes JF - Remote Sensing N2 - Atmospheric water vapour content is a key variable that controls the development of deep convective storms and rainfall extremes over the central Andes. Direct measurements of water vapour are challenging; however, recent developments in microwave processing allow the use of phase delays from L-band radar to measure the water vapour content throughout the atmosphere: Global Navigation Satellite System (GNSS)-based integrated water vapour (IWV) monitoring shows promising results to measure vertically integrated water vapour at high temporal resolutions. Previous works also identified convective available potential energy (CAPE) as a key climatic variable for the formation of deep convective storms and rainfall in the central Andes. Our analysis relies on GNSS data from the Argentine Continuous Satellite Monitoring Network, Red Argentina de Monitoreo Satelital Continuo (RAMSAC) network from 1999 to 2013. CAPE is derived from version 2.0 of the ECMWF’s (European Centre for Medium-Range Weather Forecasts) Re-Analysis (ERA-interim) and rainfall from the TRMM (Tropical Rainfall Measuring Mission) product. In this study, we first analyse the rainfall characteristics of two GNSS-IWV stations by comparing their complementary cumulative distribution function (CCDF). Second, we separately derive the relation between rainfall vs. CAPE and GNSS-IWV. Based on our distribution fitting analysis, we observe an exponential relation of rainfall to GNSS-IWV. In contrast, we report a power-law relationship between the daily mean value of rainfall and CAPE at the GNSS-IWV station locations in the eastern central Andes that is close to the theoretical relationship based on parcel theory. Third, we generate a joint regression model through a multivariable regression analysis using CAPE and GNSS-IWV to explain the contribution of both variables in the presence of each other to extreme rainfall during the austral summer season. We found that rainfall can be characterised with a higher statistical significance for higher rainfall quantiles, e.g., the 0.9 quantile based on goodness-of-fit criterion for quantile regression. We observed different contributions of CAPE and GNSS-IWV to rainfall for each station for the 0.9 quantile. Fourth, we identify the temporal relation between extreme rainfall (the 90th, 95th, and 99th percentiles) and both GNSS-IWV and CAPE at 6 h time steps. We observed an increase before the rainfall event and at the time of peak rainfall—both for GNSS-integrated water vapour and CAPE. We show higher values of CAPE and GNSS-IWV for higher rainfall percentiles (99th and 95th percentiles) compared to the 90th percentile at a 6-h temporal scale. Based on our correlation analyses and the dynamics of the time series, we show that both GNSS-IWV and CAPE had comparable magnitudes, and we argue to consider both climatic variables when investigating their effect on rainfall extremes. KW - Global Navigation Satellite System (GNSS) KW - GNSS-integrated water vapour KW - convective available potential energy (CAPE) KW - extreme rainfall KW - TRMM Y1 - 2021 U6 - https://doi.org/10.3390/rs13183788 SN - 2072-4292 VL - 13 IS - 18 PB - MDPI CY - Basel ER - TY - JOUR A1 - Grebenkov, Denis S. A1 - Metzler, Ralf A1 - Oshanin, Gleb T1 - A molecular relay race: sequential first-passage events to the terminal reaction centre in a cascade of diffusion controlled processes JF - New Journal of Physics (NJP) N2 - We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles. The model studied here represents a typical reaction setting encountered in diverse molecular biology systems, in which, e.g. a signal transduction proceeds via a series of consecutive 'messengers': the first messenger has to find its respective immobile target site triggering a launch of the second messenger, the second messenger seeks its own target site and provokes a launch of the third messenger and so on, resembling a relay race in human competitions. For such a molecular relay race taking place in infinite one-, two- and three-dimensional systems, we find exact expressions for the probability density function of the time instant of the terminal reaction event, conditioned on preceding successful reaction events on an ordered array of target sites. The obtained expressions pertain to the most general conditions: number of intermediate stages and the corresponding diffusion coefficients, the sizes of the target sites, the distances between them, as well as their reactivities are arbitrary. KW - diffusion KW - reaction cascade KW - first passage time Y1 - 2021 U6 - https://doi.org/10.1088/1367-2630/ac1e42 SN - 1367-2630 VL - 23 PB - IOP - Institute of Physics Publishing CY - Bristol ER - TY - JOUR A1 - Perach, Shai A1 - Alexandron, Giora T1 - A MOOC-Based Computer Science Program for Middle School BT - Results, Challenges, and the Covid-19 Effect JF - EMOOCs 2021 N2 - In an attempt to pave the way for more extensive Computer Science Education (CSE) coverage in K-12, this research developed and made a preliminary evaluation of a blended-learning Introduction to CS program based on an academic MOOC. Using an academic MOOC that is pedagogically effective and engaging, such a program may provide teachers with disciplinary scaffolds and allow them to focus their attention on enhancing students’ learning experience and nurturing critical 21st-century skills such as self-regulated learning. As we demonstrate, this enabled us to introduce an academic level course to middle-school students. In this research, we developed the principals and initial version of such a program, targeting ninth-graders in science-track classes who learn CS as part of their standard curriculum. We found that the middle-schoolers who participated in the program achieved academic results on par with undergraduate students taking this MOOC for academic credit. Participating students also developed a more accurate perception of the essence of CS as a scientific discipline. The unplanned school closure due to the COVID19 pandemic outbreak challenged the research but underlined the advantages of such a MOOCbased blended learning program above classic pedagogy in times of global or local crises that lead to school closure. While most of the science track classes seem to stop learning CS almost entirely, and the end-of-year MoE exam was discarded, the program’s classes smoothly moved to remote learning mode, and students continued to study at a pace similar to that experienced before the school shut down. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-517133 SN - 978-3-86956-512-5 VL - 2021 SP - 111 EP - 127 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kindermann, Liana A1 - Dobler, Magnus A1 - Niedeggen, Daniela A1 - Linstädter, Anja T1 - A new protocol for estimation of woody aboveground biomass in disturbance-prone ecosystems JF - Ecological indicators : integrating monitoring, assessment and management N2 - Almost one third of global drylands are open forests and savannas, which are typically shaped by frequent natural disturbances such as wildfire and herbivory. Studies on ecosystem functions and services of woody vegetation require robust estimates of aboveground biomass (AGB). However, most methods have been developed for comparatively undisturbed forest ecosystems. As they are not tailored to accurately quantify AGB of small and irregular growth forms, their application on these growth forms may lead to unreliable or even biased AGB estimates in disturbance-prone dryland ecosystems. Moreover, these methods cannot quantify AGB losses caused by disturbance agents. Here we propose a methodology to estimate individual-and stand-level woody AGB in disturbance-prone ecosystems. It consists of flexible field sampling routines and estimation workflows for six growth classes, delineated by size and damage criteria. It also comprises a detailed damage assessment, harnessing the ecological archive of woody growth for past disturbances. Based on large inventories collected along steep gradients of elephant disturbances in African dryland ecosystems, we compared the AGB estimates generated with our proposed method against estimates from a less adapted forest inventory method. We evaluated the necessary stepwise procedures of method adaptation and analyzed each step's effect on stand-level AGB estimation. We further explored additional advantages of our proposed method with regard to disturbance impact quantification. Results indicate that a majority of growth forms and individuals in savanna vegetation could only be assessed if methods of AGB estimation were adapted to the conditions of a disturbance-prone ecosystem. Furthermore, our damage assessment demonstrated that one third to half of all woody AGB was lost to disturbances. Consequently, less adapted methods may be insufficient and are likely to render inaccurate AGB estimations. Our proposed method has the potential to accurately quantify woody AGB in disturbance-prone ecosystems, as well as AGB losses. Our method is more time consuming than conventional allometric approaches, yet it can cover sufficient areas within reasonable timespans, and can also be easily adapted to alternative sampling schemes. KW - Damage assessment KW - Disturbance impacts KW - Tree growth classes KW - Method KW - comparison KW - Flexible sampling strategy KW - Tree allometry KW - Woody KW - aboveground biomass Y1 - 2021 U6 - https://doi.org/10.1016/j.ecolind.2021.108466 SN - 1470-160X SN - 1872-7034 VL - 135 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Göthel, Markus A1 - Listek, Martin A1 - Messerschmidt, Katrin A1 - Schlör, Anja A1 - Hönow, Anja A1 - Hanack, Katja T1 - A New Workflow to Generate Monoclonal Antibodies against Microorganisms JF - Applied Sciences N2 - Monoclonal antibodies are used worldwide as highly potent and efficient detection reagents for research and diagnostic applications. Nevertheless, the specific targeting of complex antigens such as whole microorganisms remains a challenge. To provide a comprehensive workflow, we combined bioinformatic analyses with novel immunization and selection tools to design monoclonal antibodies for the detection of whole microorganisms. In our initial study, we used the human pathogenic strain E. coli O157:H7 as a model target and identified 53 potential protein candidates by using reverse vaccinology methodology. Five different peptide epitopes were selected for immunization using epitope-engineered viral proteins. The identification of antibody-producing hybridomas was performed by using a novel screening technology based on transgenic fusion cell lines. Using an artificial cell surface receptor expressed by all hybridomas, the desired antigen-specific cells can be sorted fast and efficiently out of the fusion cell pool. Selected antibody candidates were characterized and showed strong binding to the target strain E. coli O157:H7 with minor or no cross-reactivity to other relevant microorganisms such as Legionella pneumophila and Bacillus ssp. This approach could be useful as a highly efficient workflow for the generation of antibodies against microorganisms. KW - monoclonal antibody KW - antibody producing cell selection KW - hybridoma KW - epitope prediction Y1 - 2021 U6 - https://doi.org/10.3390/app11209359 SN - 1454-5101 VL - 11 IS - 20 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wehrhan, Marc A1 - Sommer, Michael T1 - A parsimonious approach to estimate soil organic carbon applying Unmanned Aerial System (UAS) multispectral imagery and the topographic position index in a heterogeneous soil landscape JF - Remote sensing / Molecular Diversity Preservation International (MDPI) N2 - Remote sensing plays an increasingly key role in the determination of soil organic carbon (SOC) stored in agriculturally managed topsoils at the regional and field scales. Contemporary Unmanned Aerial Systems (UAS) carrying low-cost and lightweight multispectral sensors provide high spatial resolution imagery (<10 cm). These capabilities allow integrate of UAS-derived soil data and maps into digitalized workflows for sustainable agriculture. However, the common situation of scarce soil data at field scale might be an obstacle for accurate digital soil mapping. In our case study we tested a fixed-wing UAS equipped with visible and near infrared (VIS-NIR) sensors to estimate topsoil SOC distribution at two fields under the constraint of limited sampling points, which were selected by pedological knowledge. They represent all releva nt soil types along an erosion-deposition gradient; hence, the full feature space in terms of topsoils' SOC status. We included the Topographic Position Index (TPI) as a co-variate for SOC prediction. Our study was performed in a soil landscape of hummocky ground moraines, which represent a significant of global arable land. Herein, small scale soil variability is mainly driven by tillage erosion which, in turn, is strongly dependent on topography. Relationships between SOC, TPI and spectral information were tested by Multiple Linear Regression (MLR) using: (i) single field data (local approach) and (ii) data from both fields (pooled approach). The highest prediction performance determined by a leave-one-out-cross-validation (LOOCV) was obtained for the models using the reflectance at 570 nm in conjunction with the TPI as explanatory variables for the local approach (coefficient of determination (R-2) = 0.91; root mean square error (RMSE) = 0.11% and R-2 = 0.48; RMSE = 0.33, respectively). The local MLR models developed with both reflectance and TPI using values from all points showed high correlations and low prediction errors for SOC content (R-2 = 0.88, RMSE = 0.07%; R-2 = 0.79, RMSE = 0.06%, respectively). The comparison with an enlarged dataset consisting of all points from both fields (pooled approach) showed no improvement of the prediction accuracy but yielded decreased prediction errors. Lastly, the local MLR models were applied to the data of the respective other field to evaluate the cross-field prediction ability. The spatial SOC pattern generally remains unaffected on both fields; differences, however, occur concerning the predicted SOC level. Our results indicate a high potential of the combination of UAS-based remote sensing and environmental covariates, such as terrain attributes, for the prediction of topsoil SOC content at the field scale. The temporal flexibility of UAS offer the opportunity to optimize flight conditions including weather and soil surface status (plant cover or residuals, moisture and roughness) which, otherwise, might obscure the relationship between spectral data and SOC content. Pedologically targeted selection of soil samples for model development appears to be the key for an efficient and effective prediction even with a small dataset. KW - Unmanned Aerial System (UAS) KW - multispectral KW - Topographic Position Index KW - (TPI) KW - Multiple Linear Regression (MLR) KW - soil organic carbon (SOC) KW - agriculture KW - erosion KW - soil landscape KW - hummocky ground moraine Y1 - 2021 U6 - https://doi.org/10.3390/rs13183557 SN - 2072-4292 VL - 13 IS - 18 PB - MDPI CY - Basel ER - TY - JOUR A1 - Spikes, Montrai A1 - Rodríguez-Silva, Rodet A1 - Bennett, Kerri-Ann A1 - Bräger, Stefan A1 - Josaphat, James A1 - Torres-Pineda, Patricia A1 - Ernst, Anja A1 - Havenstein, Katja A1 - Schlupp, Ingo A1 - Tiedemann, Ralph T1 - A phylogeny of the genus Limia (Teleostei: Poeciliidae) suggests a single-lake radiation nested in a Caribbean-wide allopatric speciation scenario JF - BMC Research Notes N2 - Objective The Caribbean is an important global biodiversity hotspot. Adaptive radiations there lead to many speciation events within a limited period and hence are particularly prominent biodiversity generators. A prime example are freshwater fish of the genus Limia, endemic to the Greater Antilles. Within Hispaniola, nine species have been described from a single isolated site, Lake Miragoâne, pointing towards extraordinary sympatric speciation. This study examines the evolutionary history of the Limia species in Lake Miragoâne, relative to their congeners throughout the Caribbean. Results For 12 Limia species, we obtained almost complete sequences of the mitochondrial cytochrome b gene, a well-established marker for lower-level taxonomic relationships. We included sequences of six further Limia species from GenBank (total N  = 18 species). Our phylogenies are in concordance with other published phylogenies of Limia. There is strong support that the species found in Lake Miragoâne in Haiti are monophyletic, confirming a recent local radiation. Within Lake Miragoâne, speciation is likely extremely recent, leading to incomplete lineage sorting in the mtDNA. Future studies using multiple unlinked genetic markers are needed to disentangle the relationships within the Lake Miragoâne clade. KW - Cytochrome b KW - Island biogeography KW - Fresh water fish KW - Phylogeny Y1 - 2021 U6 - https://doi.org/10.1186/s13104-021-05843-x SN - 1756-0500 VL - 14 SP - 1 EP - 8 PB - BMC Research Notes / Biomed Central CY - London ER - TY - JOUR A1 - Warschburger, Petra A1 - Petersen, Ann-Christin A1 - von Rezori, Roman Enzio A1 - Buchallik, Friederike A1 - Baumeister, Harald A1 - Holl, Reinhard A1 - Minden, Kirsten A1 - Müller-​Stierlin, Annabel Sandra A1 - Reinauer, Christina A1 - Staab, Doris A1 - COACH consortium, T1 - A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study JF - BMC Pediatrics N2 - Background Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions. Methods/design We plan to consecutively recruit N = 450 adolescents (12–21 years) from three German patient registries for chronic conditions (type 1 diabetes, cystic fibrosis, or juvenile idiopathic arthritis). Based on screening for anxiety and depression, adolescents are assigned to two parallel groups – “inconspicuous” (PHQ-9 and GAD-7 < 7) vs. “conspicuous” (PHQ-9 or GAD-7 ≥ 7) – participating in a prospective online survey at baseline and 12-month follow-up. At two time points (T1, T2), we assess (1) intra- and interpersonal resiliency factors, (2) coping strategies, and (3) health-related quality of life, well-being, satisfaction with life, anxiety and depression. Using a cross-lagged panel design, we will examine the bidirectional longitudinal relations between resiliency factors and coping strategies, psychological adaptation, and psychosocial adjustment. To monitor Covid-19 pandemic effects, participants are also invited to take part in an intermediate online survey. Discussion The study will provide a deeper understanding of adaptive, potentially modifiable processes and will therefore help to develop novel, tailored interventions supporting a positive adaptation in youths with a chronic condition. These strategies should not only support those at risk but also promote the maintenance of a successful adaptation. Trial registration German Clinical Trials Register (DRKS), no. DRKS00025125. Registered on May 17, 2021. KW - Chronic conditions KW - Adolescents KW - Prospective KW - Quality of life KW - Resiliency KW - Coping KW - Protective factors KW - Type 1 diabetes KW - Juvenile idiopathic arthritis KW - Cystic fibrosis Y1 - 2021 U6 - https://doi.org/10.1186/s12887-021-02869-9 SN - 1471-2431 VL - 21 SP - 1 EP - 13 PB - BMC pediatrics CY - London ER - TY - JOUR A1 - Schmidt, Imanuel Clemens T1 - A Secular Tradition BT - Horace Kallen on American Democracy in the United States and Israel JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien N2 - This article focuses on the social philosopher Horace Kallen and the revisions he made to the concept of cultural pluralism that he first developed in the early 20th century, applying it to postwar America and the young State of Israel. It shows how he opposed the assumption that the United States’ social order was based on a “Judeo-Christian tradition.” By constructing pluralism as a civil religion and carving out space for secular self-understandings in midcentury America, Kallen attempted to preserve the integrity of his earlier political visions, developed during World War I, of pluralist societies in the United States and Palestine within an internationalist global order. While his perspective on the State of Israel was largely shaped by his American experiences, he revised his approach to politically functionalizing religious traditions as he tested his American understanding of a secular, pluralist society against the political theology effective in the State of Israel. The trajectory of Kallen’s thought points to fundamental questions about the compatibility of American and Israeli understandings of religion’s function in society and its relation to political belonging, especially in light of their transnational connection through American Jewish support for the recently established state. KW - modern Jewish history KW - United States KW - Israel KW - 20th century KW - Horace Kallen KW - cultural pluralism KW - intellectual history KW - moderne jüdische Geschichte KW - USA KW - Israel KW - 20. Jahrhundert KW - Horace Kallen KW - kultureller Pluralismus KW - Geistesgeschichte Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532868 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 85 EP - 100 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Mumm, Rebekka A1 - Hermanussen, Michael T1 - A short note on the BMI and on secular changes in BMI JF - Human biology and public health N2 - Human size changes over time with worldwide secular trends in height, weight, and body mass index (BMI). There is general agreement to relate the state of nutrition to height and weight, and to ratios of weight-to-height. The BMI is a ratio. It is commonly used to classify underweight, overweight and obesity in adults. Yet, the BMI is inappropriate to provide any immediate information on body composition. It is accepted that the BMI is “a simple index to classify underweight, overweight and obesity in adults”. It is stated that “policies, programmes and investments need to be “nutrition-sensitive”, which means they must have positive impacts on nutrition”. It is also stated that “a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions“. But these statements are neither warranted by arithmetic considerations, nor by historic evidence. Measuring the BMI is an appropriate screening tool for detecting an unusual weight-to-height ratio, but the BMI is an inappropriate tool for estimating body composition, or suggesting medical and health policy decisions. KW - body mass index KW - secular trend KW - weight-to-height ratio KW - malnutrition KW - obesity Y1 - 2021 U6 - https://doi.org/10.52905/hbph.v2.17 SN - 2748-9957 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schlemm, Tanja A1 - Levermann, Anders T1 - A simple parametrization of mélange buttressing for calving glaciers JF - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union N2 - Both ice sheets in Greenland and Antarctica are discharging ice into the ocean. In many regions along the coast of the ice sheets, the icebergs calve into a bay. If the addition of icebergs through calving is faster than their transport out of the embayment, the icebergs will be frozen into a melange with surrounding sea ice in winter. In this case, the buttressing effect of the ice melange can be considerably stronger than any buttressing by mere sea ice would be. This in turn stabilizes the glacier terminus and leads to a reduction in calving rates. Here we propose a simple parametrization of ice melange buttressing which leads to an upper bound on calving rates and can be used in numerical and analytical modelling. Y1 - 2021 U6 - https://doi.org/10.5194/tc-15-531-2021 SN - 1994-0416 SN - 1994-0424 VL - 15 IS - 2 SP - 531 EP - 545 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Körting, Friederike Magdalena A1 - Köllner, Nicole A1 - Kuras, Agnieszka A1 - Bösche, Nina Kristin A1 - Rogass, Christian A1 - Mielke, Christian A1 - Elger, Kirsten A1 - Altenberger, Uwe T1 - A solar optical hyperspectral library of rare-earth-bearing minerals, rare-earth oxide powders, copper-bearing minerals and Apliki mine surface samples JF - Earth system science data : ESSD N2 - Mineral resource exploration and mining is an essential part of today's high-tech industry. Elements such as rare-earth elements (REEs) and copper are, therefore, in high demand. Modern exploration techniques from multiple platforms (e.g., spaceborne and airborne), to detect and map the spectral characteristics of the materials of interest, require spectral libraries as an essential reference. They include field and laboratory spectral information in combination with geochemical analyses for validation. Here, we present a collection of REE- and copper-related hyperspectral spectra with associated geochemical information. The libraries contain reflectance spectra from rare-earth element oxides, REE-bearing minerals, copper-bearing minerals and mine surface samples from the Apliki copper-gold-pyrite mine in the Republic of Cyprus. The samples were measured with the HySpex imaging spectrometers in the visible and near infrared (VNIR) and shortwave infrared (SWIR) range (400-2500 nm). The geochemical validation of each sample is provided with the reflectance spectra. The spectral libraries are openly available to assist future mineral mapping campaigns and laboratory spectroscopic analyses. The spectral libraries and corresponding geochemistry are published via GFZ Data Services with the following DOIs: https://doi.org/10.5880/GFZ.1.4.2019.004 (13 REE-bearing minerals and 16 oxide powders, Koerting et al., 2019a), https://doi.org/10.5880/GFZ.1.4.2019.003 (20 copper-bearing minerals, Koellner et al., 2019), and https://doi.org/10.5880/GFZ.1.4.2019.005 (37 copper-bearing surface material samples from the Apliki coppergold-pyrite mine in Cyprus, Koerting et al., 2019b). All spectral libraries are united and comparable by the internally consistent method of hyperspectral data acquisition in the laboratory. Y1 - 2021 U6 - https://doi.org/10.5194/essd-13-923-2021 SN - 1866-3508 SN - 1866-3516 VL - 13 SP - 923 EP - 942 PB - Copernics Publications CY - Katlenburg-Lindau ER - TY - JOUR A1 - Küken, Anika A1 - Wendering, Philipp A1 - Langary, Damoun A1 - Nikoloski, Zoran T1 - A structural property for reduction of biochemical networks JF - Scientific reports N2 - Large-scale biochemical models are of increasing sizes due to the consideration of interacting organisms and tissues. Model reduction approaches that preserve the flux phenotypes can simplify the analysis and predictions of steady-state metabolic phenotypes. However, existing approaches either restrict functionality of reduced models or do not lead to significant decreases in the number of modelled metabolites. Here, we introduce an approach for model reduction based on the structural property of balancing of complexes that preserves the steady-state fluxes supported by the network and can be efficiently determined at genome scale. Using two large-scale mass-action kinetic models of Escherichia coli, we show that our approach results in a substantial reduction of 99% of metabolites. Applications to genome-scale metabolic models across kingdoms of life result in up to 55% and 85% reduction in the number of metabolites when arbitrary and mass-action kinetics is assumed, respectively. We also show that predictions of the specific growth rate from the reduced models match those based on the original models. Since steady-state flux phenotypes from the original model are preserved in the reduced, the approach paves the way for analysing other metabolic phenotypes in large-scale biochemical networks. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-96835-1 SN - 2045-2322 VL - 11 IS - 1 PB - Macmillan Publishers Limited, part of Springer Nature CY - London ER - TY - JOUR A1 - Rodríguez Zuluaga, Juan A1 - Stolle, Claudia A1 - Yamazaki, Yosuke A1 - Xiong, Chao A1 - England, Scott L. T1 - A synoptic-scale wavelike structure in the nighttime equatorial ionization anomaly JF - Earth and Space Science : ESS N2 - Both ground- and satellite-based airglow imaging have significantly contributed to understanding the low-latitude ionosphere, especially the morphology and dynamics of the equatorial ionization anomaly (EIA). The NASA Global-scale Observations of the Limb and Disk (GOLD) mission focuses on far-ultraviolet airglow images from a geostationary orbit at 47.5 degrees W. This region is of particular interest at low magnetic latitudes because of the high magnetic declination (i.e., about -20 degrees) and proximity of the South Atlantic magnetic anomaly. In this study, we characterize an exciting feature of the nighttime EIA using GOLD observations from October 5, 2018 to June 30, 2020. It consists of a wavelike structure of a few thousand kilometers seen as poleward and equatorward displacements of the EIA-crests. Initial analyses show that the synoptic-scale structure is symmetric about the dip equator and appears nearly stationary with time over the night. In quasi-dipole coordinates, maxima poleward displacements of the EIA-crests are seen at about +/- 12 degrees latitude and around 20 and 60 degrees longitude (i.e., in geographic longitude at the dip equator, about 53 degrees W and 14 degrees W). The wavelike structure presents typical zonal wavelengths of about 6.7 x 10(3) km and 3.3 x 10(3) km. The structure's occurrence and wavelength are highly variable on a day-to-day basis with no apparent dependence on geomagnetic activity. In addition, a cluster or quasi-periodic wave train of equatorial plasma depletions (EPDs) is often detected within the synoptic-scale structure. We further outline the difference in observing these EPDs from FUV images and in situ measurements during a GOLD and Swarm mission conjunction. KW - equatorial ionization anomaly KW - equatorial ionosphere KW - equatorial plasma bubbles KW - wave structure KW - forcing from below Y1 - 2021 U6 - https://doi.org/10.1029/2020EA001529 SN - 2333-5084 VL - 8 IS - 2 PB - American Geophysical Union CY - Malden, Mass. ER - TY - JOUR A1 - Prill, Robert A1 - Walter, Marina A1 - Królikowska, Aleksandra A1 - Becker, Roland T1 - A systematic review of diagnostic accuracy and clinical applications of wearable movement sensors for knee joint rehabilitation JF - Sensors N2 - In clinical practice, only a few reliable measurement instruments are available for monitoring knee joint rehabilitation. Advances to replace motion capturing with sensor data measurement have been made in the last years. Thus, a systematic review of the literature was performed, focusing on the implementation, diagnostic accuracy, and facilitators and barriers of integrating wearable sensor technology in clinical practices based on a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. For critical appraisal, the COSMIN Risk of Bias tool for reliability and measurement of error was used. PUBMED, Prospero, Cochrane database, and EMBASE were searched for eligible studies. Six studies reporting reliability aspects in using wearable sensor technology at any point after knee surgery in humans were included. All studies reported excellent results with high reliability coefficients, high limits of agreement, or a few detectable errors. They used different or partly inappropriate methods for estimating reliability or missed reporting essential information. Therefore, a moderate risk of bias must be considered. Further quality criterion studies in clinical settings are needed to synthesize the evidence for providing transparent recommendations for the clinical use of wearable movement sensors in knee joint rehabilitation. KW - wearable movement sensor KW - IMU KW - motion capture KW - reliability KW - clinical KW - orthopedic Y1 - 2021 U6 - https://doi.org/10.3390/s21248221 SN - 1424-8220 VL - 21 IS - 24 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kaboth-Bahr, Stefanie A1 - Bahr, André A1 - Zeeden, Christian A1 - Yamoah, Kweku A. A1 - Lone, Mahjoor Ahmad A1 - Chuang, Chih-Kai A1 - Löwemark, Ludvig A1 - Wei, Kuo-Yen T1 - A tale of shifting relations BT - East Asian summer and winter monsoon variability during the Holocene JF - Scientific Reports N2 - Understanding the dynamics between the East Asian summer (EASM) and winter monsoon (EAWM) is needed to predict their variability under future global warming scenarios. Here, we investigate the relationship between EASM and EAWM as well as the mechanisms driving their variability during the last 10,000 years by stacking marine and terrestrial (non-speleothem) proxy records from the East Asian realm. This provides a regional and proxy independent signal for both monsoonal systems. The respective signal was subsequently analysed using a linear regression model. We find that the phase relationship between EASM and EAWM is not time-constant and significantly depends on orbital configuration changes. In addition, changes in the Atlantic Meridional Overturning circulation, Arctic sea-ice coverage, El Niño-Southern Oscillation and Sun Spot numbers contributed to millennial scale changes in the EASM and EAWM during the Holocene. We also argue that the bulk signal of monsoonal activity captured by the stacked non-speleothem proxy records supports the previously argued bias of speleothem climatic archives to moisture source changes and/or seasonality. KW - Environmental sciences KW - Ocean sciences KW - Solid Earth sciences Y1 - 2020 U6 - https://doi.org/10.1038/s41598-021-85444-7 SN - 2045-2322 VL - 11 PB - Macmillan Publishers Limited, part of Springer Nature CY - London ER - TY - JOUR A1 - Doering, Ulrike A1 - Grigoriev, Dmitry A1 - Tapio, Kosti A1 - Rosencrantz, Sophia A1 - Rosencrantz, Ruben R. A1 - Bald, Ilko A1 - Böker, Alexander T1 - About the mechanism of ultrasonically induced protein capsule formation JF - RSC Advances : an international journal to further the chemical sciences / Royal Society of Chemistry N2 - In this paper, we propose a consistent mechanism of protein microcapsule formation upon ultrasound treatment. Aqueous suspensions of bovine serum albumin (BSA) microcapsules filled with toluene are prepared by use of high-intensity ultrasound following a reported method. Stabilization of the oil-in-water emulsion by the adsorption of the protein molecules at the interface of the emulsion droplets is accompanied by the creation of the cross-linked capsule shell due to formation of intermolecular disulfide bonds caused by highly reactive species like superoxide radicals generated sonochemically. The evidence for this mechanism, which until now remained elusive and was not proven properly, is presented based on experimental data from SDS-PAGE, Raman spectroscopy and dynamic light scattering. Y1 - 2021 U6 - https://doi.org/10.1039/d0ra08100k SN - 2046-2069 VL - 11 IS - 27 SP - 16152 EP - 16157 PB - RSC Publishing CY - London ER - TY - JOUR A1 - Kulawiak, Pawel R. T1 - Academic benefits of wearing noise-cancelling headphones during class for typically developing students and students with special needs BT - a scoping review JF - Cogent education N2 - Classroom noise impairs students' cognition and learning. At a first glance, it seems useful to prevent the negative effects of noise on academic learning by wearing noise-cancelling (NC) headphones during class. The literature and guidelines emphasize the academic benefits of wearing NC headphones (decreased auditory distraction, increased concentration, learning improvement, and decreased distress). These benefits are particularly expected for students with special needs. None of the recommendations to wear NC headphones during class refer to any empirical studies, indicating a potential research gap and lack of evidence. Therefore, the question arises: Is there any empirical evidence supporting academic benefits of wearing NC headphones during class for typically developing students or students with special needs? A total of 13 empirical studies (quantitative and qualitative) were identified through a systematic scoping review of the existing literature. A wide range of outcomes (cognition, learning, academic performance, behaviour, and emotions) were reported related to the use of NC headphones. Most of the studies refer to specific groups of students with special needs (learning disabilities, autism, ADHD, etc.). In view of the limited number of studies, small sample sizes, and lack of replication studies, all studies give the impression of being pilot studies on the academic benefits of wearing NC headphones. The practice of wearing NC headphones during class is an understudied topic. The current body of evidence does not meet the standards for evidence-based practices in both general and special education. Implications for educational practice and future research are discussed. KW - classroom noise KW - academic performance KW - noise-cancelling headphones KW - special needs KW - scoping review Y1 - 2021 U6 - https://doi.org/10.1080/2331186X.2021.1957530 SN - 2331-186X VL - 8 IS - 1 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Hammami, Raouf A1 - Chaabene, Helmi A1 - Kharrat, Fatma A1 - Werfelli, Hanen A1 - Duncan, Michael A1 - Rebai, Haithem A1 - Granacher, Urs T1 - Acute effects of different balance exercise types on selected measures of physical fitness in youth female volleyball players JF - BMC Sports Science, Medicine and Rehabilitation N2 - Background Earlier studies have shown that balance training (BT) has the potential to induce performance enhancements in selected components of physical fitness (i.e., balance, muscle strength, power, speed). While there is ample evidence on the long-term effects of BT on components of physical fitness in youth, less is known on the short-term or acute effects of single BT sessions on selected measures of physical fitness. Objective To examine the acute effects of different balance exercise types on balance, change-of-direction (CoD) speed, and jump performance in youth female volleyball players. Methods Eleven female players aged 14 years participated in this study. Three types of balance exercises (i.e., anterior, posterolateral, rotational type) were conducted in randomized order. For each exercise, 3 sets including 5 repetitions were performed. Before and after the performance of the balance exercises, participants were tested for their static balance (center of pressure surface area [CoP SA] and velocity [CoP V]) on foam and firm surfaces, CoD speed (T-Half test), and vertical jump height (countermovement jump [CMJ] height). A 3 (condition: anterior, mediolateral, rotational balance exercise type) × 2 (time: pre, post) analysis of variance was computed with repeated measures on time. Results Findings showed no significant condition × time interactions for all outcome measures (p > 0.05). However, there were small main effects of time for CoP SA on firm and foam surfaces (both d = 0.38; all p < 0.05) with no effect for CoP V on both surface conditions (p > 0.05). For CoD speed, findings showed a large main effect of time (d = 0.91; p < 0.001). However, for CMJ height, no main effect of time was observed (p > 0.05). Conclusions Overall, our results indicated small-to-large changes in balance and CoD speed performances but not in CMJ height in youth female volleyball players, regardless of the balance exercise type. Accordingly, it is recommended to regularly integrate balance exercises before the performance of sport-specific training to optimize performance development in youth female volleyball players. KW - Postural stability KW - Conditioning activity KW - Short‐term effect KW - Team sports KW - Youth Y1 - 2021 U6 - https://doi.org/10.1186/s13102-021-00249-5 SN - 1758-2555 VL - 13 PB - BioMed Central CY - London ER - TY - JOUR A1 - Werfelli, Hanen A1 - Hammami, Raouf A1 - Selmi, Mohamed Amine A1 - Selmi, Walid A1 - Gabrilo, Goran A1 - Clark, Cain C. T. A1 - Duncan, Michael A1 - Sekulic, Damir A1 - Granacher, Urs A1 - Rebai, Haithem T1 - Acute Effects of Different Plyometric and Strength Exercises on Balance Performance in Youth Weightlifters JF - Frontiers in Physiology N2 - Background: High-intensity muscle actions have the potential to temporarily improve the performance which has been denoted as postactivation performance enhancement. Objectives: This study determined the acute effects of different stretch-shortening (fast vs. low) and strength (dynamic vs. isometric) exercises executed during one training session on subsequent balance performance in youth weightlifters. Materials and Methods: Sixteen male and female young weightlifters, aged 11.3±0.6years, performed four strength exercise conditions in randomized order, including dynamic strength (DYN; 3 sets of 3 repetitions of 10 RM) and isometric strength exercises (ISOM; 3 sets of maintaining 3s of 10 RM of back-squat), as well as fast (FSSC; 3 sets of 3 repetitions of 20-cm drop-jumps) and slow (SSSC; 3 sets of 3 hurdle jumps over a 20-cm obstacle) stretch-shortening cycle protocols. Balance performance was tested before and after each of the four exercise conditions in bipedal stance on an unstable surface (i.e., BOSU ball with flat side facing up) using two dependent variables, i.e., center of pressure surface area (CoP SA) and velocity (CoP V). Results: There was a significant effect of time on CoP SA and CoP V [F(1,60)=54.37, d=1.88, p<0.0001; F(1,60)=9.07, d=0.77, p=0.003]. In addition, a statistically significant effect of condition on CoP SA and CoP V [F(3,60)=11.81, d=1.53, p<0.0001; F(3,60)=7.36, d=1.21, p=0.0003] was observed. Statistically significant condition-by-time interactions were found for the balance parameters CoP SA (p<0.003, d=0.54) and CoP V (p<0.002, d=0.70). Specific to contrast analysis, all specified hypotheses were tested and demonstrated that FSSC yielded significantly greater improvements than all other conditions in CoP SA and CoP V [p<0.0001 (d=1.55); p=0.0004 (d=1.19), respectively]. In addition, FSSC yielded significantly greater improvements compared with the two conditions for both balance parameters [p<0.0001 (d=2.03); p<0.0001 (d=1.45)]. Conclusion: Fast stretch-shortening cycle exercises appear to be more effective to improve short-term balance performance in young weightlifters. Due to the importance of balance for overall competitive achievement in weightlifting, it is recommended that young weightlifters implement dynamic plyometric exercises in the fast stretch-shortening cycle during the warm-up to improve their balance performance. KW - postural stability KW - conditioning exercise KW - adolescents KW - performance KW - weightlifting Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.716981 SN - 1664-042X VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Dellepiane, Sergio A1 - Vaid, Akhil A1 - Jaladanki, Suraj K. A1 - Coca, Steven A1 - Fayad, Zahi A. A1 - Charney, Alexander W. A1 - Böttinger, Erwin A1 - He, John Cijiang A1 - Glicksberg, Benjamin S. A1 - Chan, Lili A1 - Nadkarni, Girish T1 - Acute kidney injury in patients hospitalized with COVID-19 in New York City BT - Temporal Trends From March 2020 to April 2021 JF - Kidney medicine Y1 - 2021 U6 - https://doi.org/10.1016/j.xkme.2021.06.008 SN - 2590-0595 VL - 3 IS - 5 SP - 877 EP - 879 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Romero-Mujalli, Daniel A1 - Rochow, Markus A1 - Kahl, Sandra M. A1 - Paraskevopoulou, Sofia A1 - Folkertsma, Remco A1 - Jeltsch, Florian A1 - Tiedemann, Ralph T1 - Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies JF - Ecology and Evolution N2 - Populations adapt to novel environmental conditions by genetic changes or phenotypic plasticity. Plastic responses are generally faster and can buffer fitness losses under variable conditions. Plasticity is typically modeled as random noise and linear reaction norms that assume simple one-to- one genotype–phenotype maps and no limits to the phenotypic response. Most studies on plasticity have focused on its effect on population viability. However, it is not clear, whether the advantage of plasticity depends solely on environmental fluctuations or also on the genetic and demographic properties (life histories) of populations. Here we present an individual-based model and study the relative importance of adaptive and nonadaptive plasticity for populations of sexual species with different life histories experiencing directional stochastic climate change. Environmental fluctuations were simulated using differentially autocorrelated climatic stochasticity or noise color, and scenarios of directiona climate change. Nonadaptive plasticity was simulated as a random environmental effect on trait development, while adaptive plasticity as a linear, saturating, or sinusoidal reaction norm. The last two imposed limits to the plastic response and emphasized flexible interactions of the genotype with the environment. Interestingly, this assumption led to (a) smaller phenotypic than genotypic variance in the population (many-to- one genotype–phenotype map) and the coexistence of polymorphisms, and (b) the maintenance of higher genetic variation—compared to linear reaction norms and genetic determinism—even when the population was exposed to a constant environment for several generations. Limits to plasticity led to genetic accommodation, when costs were negligible, and to the appearance of cryptic variation when limits were exceeded. We found that adaptive plasticity promoted population persistence under red environmental noise and was particularly important for life histories with low fecundity. Populations produing more offspring could cope with environmental fluctuations solely by genetic changes or random plasticity, unless environmental change was too fast. KW - developmental canalization KW - environmental change KW - genetic accommodation KW - Individual-based models KW - limits KW - many-to-one genotype–phenotype map KW - noise color KW - phenotypic plasticity KW - reaction norms KW - stochastic fluctuations Y1 - 2020 SN - 2045-7758 VL - 11 IS - 11 PB - John Wiley & Sons, Inc. CY - New Jersey ER - TY - JOUR A1 - Schaefer, Laura A1 - Dech, Silas A1 - Bittmann, Frank T1 - Adaptive force and emotionally related imaginations BT - Preliminary results suggest a reduction of the maximal holding capacity as reaction to disgusting food imagination JF - Heliyon N2 - The link between emotions and motor control has been discussed for years. The measurement of the Adaptive Force (AF) provides the possibility to get insights into the adaptive control of the neuromuscular system in reaction to external forces. It was hypothesized that the holding isometric AF is especially vulnerable to disturbing inputs. Here, the behavior of the AF under the influence of positive (tasty) vs. negative (disgusting) food imaginations was investigated. The AF was examined in n = 12 cases using an objectified manual muscle test of the hip flexors, elbow flexors or pectoralis major muscle, performed by one of two experienced testers while the participants imagined their most tasty or most disgusting food. The reaction force and the limb position were measured by a handheld device. While the slope of force rises and the maximal AF did not differ significantly between tasty and disgusting imaginations (p > 0.05), the maximal isometric AF was significantly lower and the AF at the onset of oscillations was significantly higher under disgusting vs. tasty imaginations (both p = 0.001). A proper length tension control of muscles seems to be a crucial functional parameter of the neuromuscular system which can be impaired instantaneously by emotionally related negative imaginations. This might be a potential approach to evaluate somatic reactions to emotions. KW - Adaptive Force KW - Isometric Adaptive Force KW - Holding capacity KW - Holding KW - isometric muscle action KW - Imaginations KW - Emotions KW - Motor control KW - Functional weakness KW - Manual muscle test Y1 - 2021 U6 - https://doi.org/10.1016/j.heliyon.2021.e07827 SN - 2405-8440 VL - 7 IS - 8 PB - Elsevier CY - London ER - TY - JOUR A1 - Birukov, Anna A1 - Cuadrat, Rafael R. C. A1 - Polemiti, Elli A1 - Eichelmann, Fabian A1 - Schulze, Matthias Bernd T1 - Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals BT - a cross-sectional study JF - Cardiovascular diabetology N2 - Background Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships between advanced glycation end-products, measured as skin autofluorescence, and vascular stiffness in various glycemic strata. Methods We performed a cross-sectional analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort, comprising n = 3535 participants (median age 67 years, 60% women). Advanced glycation end-products were measured as skin autofluorescence with AGE-Reader (TM), vascular stiffness was measured as pulse wave velocity, augmentation index and ankle-brachial index with Vascular Explorer (TM). A subset of 1348 participants underwent an oral glucose tolerance test. Participants were sub-phenotyped into normoglycemic, prediabetes and diabetes groups. Associations between skin autofluorescence and various indices of vascular stiffness were assessed by multivariable regression analyses and were adjusted for age, sex, measures of adiposity and lifestyle, blood pressure, prevalent conditions, medication use and blood biomarkers. Results Skin autofluorescence associated with pulse wave velocity, augmentation index and ankle-brachial index, adjusted beta coefficients (95% CI) per unit skin autofluorescence increase: 0.38 (0.21; 0.55) for carotid-femoral pulse wave velocity, 0.25 (0.14; 0.37) for aortic pulse wave velocity, 1.00 (0.29; 1.70) for aortic augmentation index, 4.12 (2.24; 6.00) for brachial augmentation index and - 0.04 (- 0.05; - 0.02) for ankle-brachial index. The associations were strongest in men, younger individuals and were consistent across all glycemic strata: for carotid-femoral pulse wave velocity 0.36 (0.12; 0.60) in normoglycemic, 0.33 (- 0.01; 0.67) in prediabetes and 0.45 (0.09; 0.80) in diabetes groups; with similar estimates for aortic pulse wave velocity. Augmentation index was associated with skin autofluorescence only in normoglycemic and diabetes groups. Ankle-brachial index inversely associated with skin autofluorescence across all sex, age and glycemic strata. Conclusions Our findings indicate that advanced glycation end-products measured as skin autofluorescence might be involved in vascular stiffening independent of age and other cardiometabolic risk factors not only in individuals with diabetes but also in normoglycemic and prediabetic conditions. Skin autofluorescence might prove as a rapid and non-invasive method for assessment of macrovascular disease progression across all glycemic strata. KW - Advanced glycation end-products KW - AGE KW - Ankle-brachial index KW - Augmentation KW - index KW - Prediabetes KW - Glycemia KW - Pulse wave velocity KW - Skin KW - autofluorescence KW - Vascular stiffness Y1 - 2021 U6 - https://doi.org/10.1186/s12933-021-01296-5 SN - 1475-2840 VL - 20 IS - 1 PB - BioMed Central CY - London ER - TY - JOUR A1 - Robin, Koger A1 - Katharina, Syböck A1 - Emily, Weinelt A1 - Beda, Hartmann A1 - Kirchengast, Sylvia ED - Scheffler, Christiane ED - Koziel, Slawomir ED - Hermanussen, Michael ED - Bogin, Barry T1 - Advanced maternal age and nicotine consumption during pregnancy BT - Additive effects on new-born parameters T2 - Human Biology and Public Health N2 - Background Nicotine consumption during pregnancy and advanced maternal age are well known independent risk factors for poor pregnancy outcome and therefore serious public health problems. Objectives Considering the ongoing trend of delaying childbirth in our society, this study investigates potential additive effects of nicotine consumption during pregnancy and advanced maternal age on foetal growth. Sample and Methods In a medical record-based study, we analysed the impact of maternal age and smoking behaviour before and during pregnancy on newborn size among 4142 singleton births that took place in Vienna, Austria between 1990 and 1995. Results Birth weight (H=82.176, p<0.001), birth length (H=91.525, p<0.001) and head circumference (H=42.097, p<0.001) differed significantly according to maternal smoking behaviour. For birth weight, the adjusted mean differences between smokers and non-smokers increased from 101.8g for the < 18-year-old mothers to 254.8g for >35 year olds, with the respective values for birth length being 0.6 cm to 0.7cm, for head circumference from 0.3 cm to 0.6 cm. Conclusion Increasing maternal age amplified the negative effects of smoking during pregnancy on newborn parameters. Our findings identify older smoking mothers as a high-risk group which should be of special interest for public health systems. KW - advanced maternal age at first birth KW - maternal nicotine consumption KW - foetal growth KW - newborn size KW - birthweight KW - smoking Y1 - 2021 U6 - https://doi.org/10.52905/hbph.v1.6 SN - 2748-9957 VL - 2021 IS - 1 SP - 1 EP - 19 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Fühner, Thea Heidi A1 - Granacher, Urs A1 - Golle, Kathleen A1 - Kliegl, Reinhold T1 - Age and sex effects in physical fitness components of 108,295 third graders including 515 primary schools and 9 cohorts JF - Scientific Reports N2 - Children’s physical fitness development and related moderating effects of age and sex are well documented, especially boys’ and girls’ divergence during puberty. The situation might be different during prepuberty. As girls mature approximately two years earlier than boys, we tested a possible convergence of performance with five tests representing four components of physical fitness in a large sample of 108,295 eight-year old third-graders. Within this single prepubertal year of life and irrespective of the test, performance increased linearly with chronological age, and boys outperformed girls to a larger extent in tests requiring muscle mass for successful performance. Tests differed in the magnitude of age effects (gains), but there was no evidence for an interaction between age and sex. Moreover, “physical fitness” of schools correlated at r = 0.48 with their age effect which might imply that "fit schools” promote larger gains; expected secular trends from 2011 to 2019 were replicated. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-97000-4 SN - 2045-2322 VL - 11 SP - 1 EP - 13 PB - Nature Portfolio CY - Berlin ER - TY - JOUR A1 - Schlomann, Anna A1 - Bünning, Mareike A1 - Hipp, Lena A1 - Wahl, Hans-Werner T1 - Aging during COVID-19 in Germany BT - a longitudinal analysis of psychosocial adaptation JF - European journal of ageing : social, behavioural and health perspectives N2 - Existing theories of aging suggest that there may be similarities and differences in how COVID-19 impacts older people’s psychosocial adaptation compared to younger age groups, particularly middle-aged individuals. To assess the degree to which these impacts vary, we analyzed data from 3098 participants between the ages of 40 and 79 from an online survey in Germany. Data were collected at three measurement occasions between the start of the nationwide lockdown in mid-March 2020 and the end of the lockdown in early August 2020. The survey focused on everyday experiences during the COVID-19 crisis and collected various satisfaction ratings (e.g., general life satisfaction, satisfaction with family life, satisfaction with social contacts). At baseline, participants also provided retrospective ratings of satisfaction for the period before the COVID-19 crisis. In our analyses, we compared satisfaction ratings of middle-aged (40–64 years) and older individuals (65–79 years) and found that both middle-aged and older participants experienced the greatest decreases in satisfaction with social contacts, with more pronounced decreases seen in middle-aged participants. A similar pattern was observed for general life satisfaction, but the overall decreases were less pronounced in both groups compared to the decreases in satisfaction with social contacts. We also observed a partial recovery effect in all measures at the last measurement occasion, and this effect was more pronounced in older adults. Findings were also confirmed using age as a continuous variable and checking for linear and nonlinear effects of outcomes across the age range. Although ageism arose during the pandemic in the sense that older adults were labeled as a “risk group,” particularly at the start of the outbreak, we found consistently with other studies that middle-aged adults’ satisfaction decreased to a greater extent than that of older adults. KW - Coronavirus pandemic KW - older adults KW - satisfaction with life KW - satisfaction with social relations KW - age stereotypes KW - longitudinal survey study Y1 - 2021 U6 - https://doi.org/10.1007/s10433-021-00655-1 SN - 1613-9372 SN - 1613-9380 VL - 19 IS - 4 SP - 1077 EP - 1086 PB - Springer CY - Berlin ER - TY - JOUR A1 - Sternagel, Renate ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - Alexander von Humboldt, Therese von Bacheracht, und die „verhängnissvolle Prosa des Lebens“ T2 - HiN : Alexander von Humboldt im Netz N2 - Ausgehend von einem Brief Alexander von Humboldts an die Schriftstellerin Therese von Bacheracht(1804 – 1852) wird die Geschichte der Herausgabe der Briefe seines Bruders Wilhelm an Charlotte Diede im Jahr 1847, nach dem Tod beider Korrespondenten, nachgezeichnet. Besonders wird dabei auf die bisher unveröffentlichten „Tagesblätter“ Karl August Varnhagens von Ense zurückgegriffen, aus denen hervorgeht, dass Alexander von Humboldt seine anfangs ablehnende Haltung aufgibt, Varnhagen mit der Prüfung und Korrektur des Manuskripts betraut, und dass Therese von Bacheracht durch Hartnäckigkeit und Charme ihr Ziel erreicht, die nicht unbeträchtlichen Einnahmen aus der Veröffentlichung zugesprochen zu bekommen. N2 - Using a letter written by Alexander von Humboldt to the writer Therese von Bacheracht (1804 – 1852), this paper tells the story of how Humboldt’s brother Wilhelm’s letters to Charlotte Diede were published in 1847, after the death of both correspondents. The emphasis is placed on the hitherto unpublished daily journals (Tagesblätter) of Karl August Varnhagen von Ense. Not only do they show how gradually Alexander von Humboldt abandons his former adverse attitude towards the project, but also that he asks Varnhagen to proofread the manuscript and that, by perseverance and her charming attitude, Therese von Bacheracht succeeds in obtaining considerable profi ts from the publication of the letters. N2 - Sur la base d’une lettre d’Alexander von Humboldt à l’écrivain Therese von Bacheracht (1804 – 1852), on retrace l’histoire de la publication des lettres de son frère Wilhelm à Charlotte Diede en 1847, après la mort des deux correspondants. En particulier, on utilise les «Tagesblätter» inédits de Karl August Varnhagen von Ense, dont il ressort qu’Alexander von Humboldt renonce à son attitude initialement négative, confi e à Varnhagen la révision et la correction du manuscrit, et que Therese von Bacheracht avec persévérance et charme atteint leur objectif de se voir attribuer les revenus non négligeables de la publication. KW - Therese von Bacheracht KW - Wilhelm von Humboldt KW - Charlotte Diede KW - Tagesblätter Karl August Varnhagens von Ense Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-533283 SN - 2568-3543 SN - 1617-5239 VL - XXII IS - 43 SP - 83 EP - 100 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Le Brun-Ricalens, Foni A1 - Luján, Leonardo López A1 - Wey, Claude ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - Alexander von Humboldts „Aztekische Priesterin“ alias die Chalchiuhtlicue aus der Sammlung Guillermo Dupaix. Historiografi scher Essay einer Translokation von Mexico-Stadt nach London BT - Historiografi scher Essay einer Translokation von Mexico-Stadt nach London JF - HiN : Alexander von Humboldt im Netz N2 - Während seines Aufenthalts 1803 in Mexiko machte von Humboldt die Bekanntschaft von Dupaix, einem spanischen Soldaten luxemburgischer Herkunft und Liebhaber präkolumbischer Altertümer. Die Entdeckung verschiedener Manuskripte Dupaix’ sowie die Untersuchung diverser Archive und persönlicher Aufzeichnungen des Freiherrn und von Dokumenten unterschiedlicher Institutionen beiderseits des Atlantiks erlauben es, den außergewöhnlichen Weg eines berühmten mexikanischen Objekts, der Chalchiuhtlicue, nachzuvollziehen, die der preußische Forschungsreisende 1810 als „aztekische Priesterin“ in seinem Buch Vues des cordillères … beschrieben hatte. Der vorliegende Beitrag versucht, die verschiedenen Besitzer und die Umstände nachzuzeichnen, welche die Wanderung dieser emblematischen prähispanischen Statuette von Mexiko-Stadt nach London fast ein halbes Jahrhundert lang begleitet haben. N2 - In 1803, during his sojourn in Mexico, von Humboldt made the acquaintance of Dupaix, a Spanish soldier of Luxemburgish origin with a keen interest in pre-Columbian art. The discovery of several manuscripts belonging to Dupaix, together with a study of various archives and personal notes left by Humboldt, not to mention the documents held in different institutions on both sides of the Atlantic, have made it possible to recreate the remarkable itinerary of a famous Mexica work of art, that of Chalchiuhtlicue. In his ground-breaking work Vues des cordillères … published in 1810, the Prussian explorer had referred to her as an “Aztec Priestess”. In this article we attempt to trace the various successive owners of this emblematic pre-Hispanic statuette and the circumstances surrounding the period of almost 50 years it spent wandering between Mexico and London. N2 - El descubrimiento de diferentes manuscritos de Dupaix, militar español de origen luxemburgués aficionado a las antigüedades precolombinas que se entrevistó en 1803 con von Humboldt con motivo de su estancia en México, unido al examen de diversos archivos y notas personales del barón, así como de documentos conservados en diversas instituciones de uno y otro lado del Atlántico, permite seguir el recorrido singular de una célebre antigüedad mexicana, a saber la Chalchiuhtlicue, que el explorador prusiano identifi có en 1810 como una “sacerdotisa azteca” en su obra Vues des cordillères… La presente contribución intenta rastrear a los sucesivos diferentes propietarios y las circunstancias que han acompañado durante más de medio siglo a la peregrinación de esta emblemática estatuilla prehispánica de México a Londres. KW - Lateinamerika KW - Mexiko KW - British Museum KW - Translokation KW - Historiografie KW - Guillermo Dupaix KW - Mexikanische Wassergöttin KW - Chalchiuhtlicue Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532802 SN - 2568-3543 SN - 1617-5239 VL - XXII IS - 43 SP - 13 EP - 28 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Warszawski, Lila A1 - Kriegler, Elmar A1 - Lenton, Timothy M. A1 - Gaffney, Owen A1 - Jacob, Daniela A1 - Klingenfeld, Daniel A1 - Koide, Ryu A1 - Costa, María Máñez A1 - Messner, Dirk A1 - Nakicenovic, Nebojsa A1 - Schellnhuber, Hans Joachim A1 - Schlosser, Peter A1 - Takeuchi, Kazuhiko A1 - van der Leeuw, Sander A1 - Whiteman, Gail A1 - Rockström, Johan T1 - All options, not silver bullets, needed to limit global warming to 1.5 °C BT - a scenario appraisal JF - Environmental research letters N2 - Climate science provides strong evidence of the necessity of limiting global warming to 1.5 °C, in line with the Paris Climate Agreement. The IPCC 1.5 °C special report (SR1.5) presents 414 emissions scenarios modelled for the report, of which around 50 are classified as '1.5 °C scenarios', with no or low temperature overshoot. These emission scenarios differ in their reliance on individual mitigation levers, including reduction of global energy demand, decarbonisation of energy production, development of land-management systems, and the pace and scale of deploying carbon dioxide removal (CDR) technologies. The reliance of 1.5 °C scenarios on these levers needs to be critically assessed in light of the potentials of the relevant technologies and roll-out plans. We use a set of five parameters to bundle and characterise the mitigation levers employed in the SR1.5 1.5 °C scenarios. For each of these levers, we draw on the literature to define 'medium' and 'high' upper bounds that delineate between their 'reasonable', 'challenging' and 'speculative' use by mid century. We do not find any 1.5 °C scenarios that stay within all medium upper bounds on the five mitigation levers. Scenarios most frequently 'over use' CDR with geological storage as a mitigation lever, whilst reductions of energy demand and carbon intensity of energy production are 'over used' less frequently. If we allow mitigation levers to be employed up to our high upper bounds, we are left with 22 of the SR1.5 1.5 °C scenarios with no or low overshoot. The scenarios that fulfil these criteria are characterised by greater coverage of the available mitigation levers than those scenarios that exceed at least one of the high upper bounds. When excluding the two scenarios that exceed the SR1.5 carbon budget for limiting global warming to 1.5 °C, this subset of 1.5 °C scenarios shows a range of 15–22 Gt CO2 (16–22 Gt CO2 interquartile range) for emissions in 2030. For the year of reaching net zero CO2 emissions the range is 2039–2061 (2049–2057 interquartile range). KW - climate change KW - emissions scenarios KW - 1.5 ◦C KW - negative emissions Y1 - 2021 U6 - https://doi.org/10.1088/1748-9326/abfeec SN - 1748-9326 N1 - Corrigendum: 10.1088/1748-9326/acbf6a VL - 16 IS - 6 PB - IOP Publishing CY - Bristol ER - TY - JOUR A1 - Machleb, Franziska A1 - Seyboth, Margret T1 - Alles kann besser werden! BT - Eine Analyse von Fehlern beim aphasischen Benennen JF - Spektrum Patholinguistik Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510412 SN - 978-3-86956-507-1 SN - 1866-9085 SN - 1866-9433 IS - 14 SP - 121 EP - 137 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Busch, Aglaja A1 - Blasimann, Angela A1 - Mayer, Frank A1 - Baur, Heiner T1 - Alterations in sensorimotor function after ACL reconstruction during active joint position sense testing. A systematic review JF - PLOS ONE N2 - Background The anterior cruciate ligament (ACL) rupture can lead to impaired knee function. Reconstruction decreases the mechanical instability but might not have an impact on sensorimotor alterations. Objective Evaluation of the sensorimotor function measured with the active joint position sense (JPS) test in anterior cruciate ligament (ACL) reconstructed patients compared to the contralateral side and a healthy control group. Methods The databases MEDLINE, CINAHL, EMBASE, PEDro, Cochrane Library and SPORTDiscus were systematically searched from origin until April 2020. Studies published in English, German, French, Spanish or Italian language were included. Evaluation of the sensorimotor performance was restricted to the active joint position sense test in ACL reconstructed participants or healthy controls. The Preferred Items for Systematic Reviews and Meta-Analyses guidelines were followed. Study quality was evaluated using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Data was descriptively synthesized. Results Ten studies were included after application of the selective criteria. Higher angular deviation, reaching significant difference (p < 0.001) in one study, was shown up to three months after surgery in the affected limb. Six months post-operative significantly less error (p < 0.01) was found in the reconstructed leg compared to the contralateral side and healthy controls. One or more years after ACL reconstruction significant differences were inconsistent along the studies. Conclusions Altered sensorimotor function was present after ACL reconstruction. Due to inconsistencies and small magnitudes, clinical relevance might be questionable. JPS testing can be performed in acute injured persons and prospective studies could enhance knowledge of sensorimotor function throughout the rehabilitative processes. KW - Body limbs KW - Knees KW - Sensory perception KW - Anterior cruciate ligament reconstruction KW - Legs KW - Tendons KW - Surgical and invasive medical procedures KW - Systematic reviews Y1 - 2021 U6 - https://doi.org/10.1371/journal.pone.0253503 SN - 1932-6203 VL - 16 IS - 6 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Strefler, Jessica A1 - Kriegler, Elmar A1 - Bauer, Nico A1 - Luderer, Gunnar A1 - Pietzcker, Robert C. A1 - Giannousakis, Anastasis A1 - Edenhofer, Ottmar T1 - Alternative carbon price trajectories can avoid excessive carbon removal JF - Nature communications N2 - The large majority of climate change mitigation scenarios that hold warming below 2 °C show high deployment of carbon dioxide removal (CDR), resulting in a peak-and-decline behavior in global temperature. This is driven by the assumption of an exponentially increasing carbon price trajectory which is perceived to be economically optimal for meeting a carbon budget. However, this optimality relies on the assumption that a finite carbon budget associated with a temperature target is filled up steadily over time. The availability of net carbon removals invalidates this assumption and therefore a different carbon price trajectory should be chosen. We show how the optimal carbon price path for remaining well below 2 °C limits CDR demand and analyze requirements for constructing alternatives, which may be easier to implement in reality. We show that warming can be held at well below 2 °C at much lower long-term economic effort and lower CDR deployment and therefore lower risks if carbon prices are high enough in the beginning to ensure target compliance, but increase at a lower rate after carbon neutrality has been reached. KW - climate-change mitigation KW - climate sciences KW - environmental sciences Y1 - 2021 U6 - https://doi.org/10.1038/s41467-021-22211-2 SN - 2041-1723 VL - 12 IS - 1 PB - Nature Publishing Group CY - London ER - TY - CHAP A1 - Löw, Martina A1 - Sayman, Volkan A1 - Schwerer, Jona A1 - Wolf, Hannah ED - Löw, Martina ED - Sayman, Volkan ED - Schwerer, Jona ED - Wolf, Hannah T1 - Am Ende der Globalisierung BT - über die Refiguration von Räumen T2 - Am Ende der Globalisierung Y1 - 2021 SN - 978-3-8394-5402-2 SN - 978-3-8376-5402-8 U6 - https://doi.org/10.14361/9783839454022 SP - 9 EP - 22 PB - transcript CY - Bielefeld ER - TY - BOOK ED - Löw, Martina ED - Sayman, Volkan ED - Schwerer, Jona ED - Wolf, Hannah T1 - Am Ende der Globalisierung BT - über die Refiguration von Räumen T3 - Re-Figuration von Räumen N2 - Die Globalisierung ist zur allgegenwärtigen Gewissheit geworden. Doch wie zutreffend ist das Konzept »Globalisierung«, wenn zeitgleich nationale Grenzen gestärkt und transnationale Freihandelszonen ausgeweitet werden, wenn auf unterschiedlichen scales Territorien überwunden und zugleich territoriale Abgrenzungen neu gesetzt werden? Aktuelle Veränderungen als Re-Figuration von Räumen zu verstehen, ermöglicht die Analyse und Diskussion widersprüchlicher, spannungsreicher und konflikthafter räumlicher Prozesse und ihrer alltäglichen Erfahrung. Die interdisziplinären Beiträge des Bandes liefern theoretische und empirische Analysen zu politischen, digitalen und alltäglichen Räumen im Konzept der Re-Figuration. KW - Globalisierung KW - Raum KW - Re-Figuration KW - Moderne KW - Sicherheit KW - Stadt KW - Land KW - Nationalstaat KW - Europa KW - Wissen KW - Grenze KW - Digitale Planung KW - Smart City KW - Öffentlichkeit KW - Medien KW - Migration KW - Tourismus KW - Berlin KW - Wandel KW - Lebensmittel KW - Materialität KW - Soziologische Theorie KW - Soziologie KW - globalization KW - space KW - modernity KW - security KW - city KW - country KW - nation-state KW - europe KW - knowledge KW - border KW - digital planning KW - public sphere KW - media KW - tourism KW - change KW - foods KW - materiality KW - sociological theory KW - sociology Y1 - 2021 SN - 978-3-8376-5402-8 SN - 978-3-8394-5402-2 U6 - https://doi.org/10.14361/9783839454022 VL - 1 PB - transcript CY - Bielefeld ER - TY - JOUR A1 - Lange, Bastian A1 - Bürkner, Hans-Joachim T1 - Ambiguous avant-gardes and their geographies BT - on blank spots of the postgrowth debate JF - Die Erde : journal of the Geographical Society of Berlin ; Zeitschrift der Gesellschaft für Erdkunde zu Berlin N2 - In the following article, the focus is on the transformative potentials created by so-called persistence avant-gardes and prevention innovators. The text extends Bluhdorn's guiding concept of narratives of hope (Bluhdorn 2017; Bluhdorn and Butzlaff 2019) by considering those groups that are marginalized within debates on socio-ecological transformation. With a closer look at the narratives of prevention and blockade that these actors engage, the ambiguous nature of postgrowth avant-gardes is carved out. Their discursive, argumentative, and effective inhibition of transitory policies is interpreted as a pro-active potential, rather than a mere obstacle to socio-ecological transformation. Adding a geographical perspective, the paper pleads for a more precise theoretical penetration of the ambivalent figure of avantgardes when analyzing processes of local and regional postgrowth. N2 - Mit dem Beitrag richten wir den Fokus auf transformative Potenziale, die von sogenannten Beharrungsavantgar-den und Präventionsinnovatoren ausgehen. Der Text erweitert Blühdorns Leitkonzept der Hoffnungsnarrative (Blühdorn 2017; Blühdorn and Butzlaff 2019), indem er jene Gruppen in den Blick nimmt, die in den Debatten um die sozial-ökologische Transformation marginalisiert werden. Mit einem genaueren Blick auf die Präventions- und Blockade-Narrative dieser Akteure wird die Mehrdeutigkeit der Postwachstumsavantgarden herausgear-beitet. Ihre diskursive, argumentative und effektive Verhinderung transitorischer Politiken wird als proaktives Potenzial und nicht als bloßes Hindernis für eine sozial-ökologische Transformation interpretiert. Unter Hinzu-nahme einer geographischen Perspektive plädiert der Beitrag für eine präzisere theoretische Durchdringung der ambivalenten Figur der Avantgarden bei der Analyse lokaler und regionaler Postwachstumsvorgänge. KW - alternative economies KW - transformative policies KW - change agents KW - postgrowth KW - regional development KW - East Germany Y1 - 2021 U6 - https://doi.org/10.12854/erde-2021-566 SN - 0013-9998 VL - 152 IS - 4 SP - 273 EP - 287 PB - Gesellschaft für Erdkunde CY - Berlin ER - TY - JOUR A1 - Schwartz, Yitzchak T1 - American Jewish Ideas in a Transnational Jewish World, 1843–1900 JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien N2 - As mid-19th-century American Jews introduced radical changes to their religious observance and began to define Judaism in new ways, to what extent did they engage with European Jewish ideas? Historians often approach religious change among Jews from German lands during this period as if Jewish immigrants had come to America with one set of ideas that then evolved solely in conversation with their American contexts. Historians have similarly cast the kinds of Judaism Americans created as both unique to America and uniquely American. These characterizations are accurate to an extent. But to what extent did Jewish innovations in the United States take place in conversation with European Jewish developments? Looking to the 19th-century American Jewish press, this paper seeks to understand how American Jews engaged European Judaism in formulating their own ideas, understanding themselves, and understanding their place in world Judaism. KW - modern Jewish history KW - Orthodox Judaism KW - Reform Judaism KW - Isaac Leeser KW - Isaac Mayer Wise KW - print culture KW - 19th century KW - German Jewry KW - United States KW - moderne jüdische Geschichte KW - jüdische Orthodoxie KW - Reformjudentum KW - Isaac Leeser KW - Isaac Mayer Wise KW - 19. Jahrhundert KW - deutsch-jüdische Geschichte KW - USA Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532835 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 39 EP - 52 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Musculus, Lisa A1 - Tünte, Markus R. A1 - Raab, Markus A1 - Kayhan, Ezgi T1 - An Embodied Cognition Perspective on the Role of Interoception in the Development of the Minimal Self JF - Frontiers in Psychology N2 - Interoception is an often neglected but crucial aspect of the human minimal self. In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans. To do so, we first provide a comparative overview of the central accounts addressing the link between interoception and the minimal self. Grounding our arguments on the embodiment framework, we propose a bidirectional relationship between motor and interoceptive states, which jointly contribute to the development of the minimal self. We present empirical findings on interoception in development and discuss the role of interoception in the development of the minimal self. Moreover, we make theoretical predictions that can be tested in future experiments. Our goal is to provide a comprehensive view on the mechanisms underlying the minimal self by explaining the role of interoception in the development of the minimal self. KW - interoception KW - development of minimal self KW - cardioception KW - embodied cognition KW - bodily self Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.716950 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Jararnezhadgero, AmirAli A1 - Mamashli, Elaheh A1 - Granacher, Urs T1 - An Endurance-Dominated Exercise Program Improves Maximum Oxygen Consumption, Ground Reaction Forces, and Muscle Activities in Patients With Moderate Diabetic Neuropathy JF - Frontiers in physiology / Frontiers Research Foundation N2 - Background: The prevalence of diabetes worldwide is predicted to increase from 2.8% in 2000 to 4.4% in 2030. Diabetic neuropathy (DN) is associated with damage to nerve glial cells, their axons, and endothelial cells leading to impaired function and mobility. Objective: We aimed to examine the effects of an endurance-dominated exercise program on maximum oxygen consumption (VO2max), ground reaction forces, and muscle activities during walking in patients with moderate DN. Methods: Sixty male and female individuals aged 45–65 years with DN were randomly assigned to an intervention (IG, n = 30) or a waiting control (CON, n = 30) group. The research protocol of this study was registered with the Local Clinical Trial Organization (IRCT20200201046326N1). IG conducted an endurance-dominated exercise program including exercises on a bike ergometer and gait therapy. The progressive intervention program lasted 12 weeks with three sessions per week, each 40–55 min. CON received the same treatment as IG after the post-tests. Pre- and post-training, VO2max was tested during a graded exercise test using spiroergometry. In addition, ground reaction forces and lower limbs muscle activities were recorded while walking at a constant speed of ∼1 m/s. Results: No statistically significant baseline between group differences was observed for all analyzed variables. Significant group-by-time interactions were found for VO2max (p < 0.001; d = 1.22). The post-hoc test revealed a significant increase in IG (p < 0.001; d = 1.88) but not CON. Significant group-by-time interactions were observed for peak lateral and vertical ground reaction forces during heel contact and peak vertical ground reaction force during push-off (p = 0.001–0.037; d = 0.56–1.53). For IG, post-hoc analyses showed decreases in peak lateral (p < 0.001; d = 1.33) and vertical (p = 0.004; d = 0.55) ground reaction forces during heel contact and increases in peak vertical ground reaction force during push-off (p < 0.001; d = 0.92). In terms of muscle activity, significant group-by-time interactions were found for vastus lateralis and gluteus medius during the loading phase and for vastus medialis during the mid-stance phase, and gastrocnemius medialis during the push-off phase (p = 0.001–0.044; d = 0.54–0.81). Post-hoc tests indicated significant intervention-related increases in vastus lateralis (p = 0.001; d = 1.08) and gluteus medius (p = 0.008; d = 0.67) during the loading phase and vastus medialis activity during mid-stance (p = 0.001; d = 0.86). In addition, post-hoc tests showed decreases in gastrocnemius medialis during the push-off phase in IG only (p < 0.001; d = 1.28). Conclusions: This study demonstrated that an endurance-dominated exercise program has the potential to improve VO2max and diabetes-related abnormal gait in patients with DN. The observed decreases in peak vertical ground reaction force during the heel contact of walking could be due to increased vastus lateralis and gluteus medius activities during the loading phase. Accordingly, we recommend to implement endurance-dominated exercise programs in type 2 diabetic patients because it is feasible, safe and effective by improving aerobic capacity and gait characteristics. KW - oxygen consumption KW - kinetics KW - electromyography KW - diabetic KW - gait Y1 - 2021 U6 - https://doi.org/10.3389/fphys.2021.654755 SN - 1664-042X VL - 12 SP - 1 EP - 15 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Nakoudi, Konstantina A1 - Stachlewska, Iwona S. A1 - Ritter, Christoph T1 - An extended lidar-based cirrus cloud retrieval scheme BT - first application over an Arctic site JF - Optics express : the international electronic journal of optics / Optica N2 - Accurate and precise characterization of cirrus cloud geometrical and optical properties is essential for better constraining their radiative footprint. A lidar-based retrieval scheme is proposed here, with its performance assessed on fine spatio-temporal observations over the Arctic site of Ny-Alesund, Svalbard. Two contributions related to cirrus geometrical (dynamic Wavelet Covariance Transform (WCT)) and optical properties (constrained Klett) are reported. The dynamic WCT rendered cirrus detection more robust, especially for thin cirrus layers that frequently remained undetected by the classical WCT method. Regarding optical characterization, we developed an iterative scheme for determining the cirrus lidar ratio (LRci) that is a crucial parameter for aerosol - cloud discrimination. Building upon the Klett-Fernald method, the LRci was constrained by an additional reference value. In established methods, such as the double-ended Klett, an aerosol-free reference value is applied. In the proposed constrained Klett, however, the reference value was approximated from cloud-free or low cloud optical depth (COD up to 0.2) profiles and proved to agree with independent Raman estimates. For optically thin cirrus, the constrained Klett inherent uncertainties reached 50% (60-74%) in terms of COD (LRci). However, for opaque cirrus COD (LRci) uncertainties were lower than 10% (15%). The detection method discrepancies (dynamic versus static WCT) had a higher impact on the optical properties of low COD layers (up to 90%) compared to optically thicker ones (less than 10%). The constrained Klett presented high agreement with two established retrievals. For an exemplary cirrus cloud, the constrained Klett estimated the COD355 (LRci355) at 0.28 +/- 0.17 (29 +/- 4 sr), the double-ended Klett at 0.27 +/- 0.15 (32 +/- 4 sr) and the Raman retrievals at 0.22 +/- 0.12 (26 +/- 11 sr). Our approach to determine the necessary reference value can also be applied in established methods and increase their accuracy. In contrast, the classical aerosol-free assumption led to 44 sr LRci overestimation in optically thin layers and 2-8 sr in thicker ones. The multiple scattering effect was corrected using Eloranta (1998) and accounted for 50-60% extinction underestimation near the cloud base and 20-30% within the cirrus layers. Y1 - 2021 U6 - https://doi.org/10.1364/OE.414770 SN - 1094-4087 VL - 29 IS - 6 SP - 8553 EP - 8580 PB - Optical Society of America CY - Washington ER - TY - BOOK A1 - Baltzer, Wanda A1 - Hradilak, Theresa A1 - Pfennigschmidt, Lara A1 - Prestin, Luc Maurice A1 - Spranger, Moritz A1 - Stadlinger, Simon A1 - Wendt, Leo A1 - Lincke, Jens A1 - Rein, Patrick A1 - Church, Luke A1 - Hirschfeld, Robert T1 - An individual-centered approach to visualize people’s opinions and demographic information N2 - The noble way to substantiate decisions that affect many people is to ask these people for their opinions. For governments that run whole countries, this means asking all citizens for their views to consider their situations and needs. Organizations such as Africa's Voices Foundation, who want to facilitate communication between decision-makers and citizens of a country, have difficulty mediating between these groups. To enable understanding, statements need to be summarized and visualized. Accomplishing these goals in a way that does justice to the citizens' voices and situations proves challenging. Standard charts do not help this cause as they fail to create empathy for the people behind their graphical abstractions. Furthermore, these charts do not create trust in the data they are representing as there is no way to see or navigate back to the underlying code and the original data. To fulfill these functions, visualizations would highly benefit from interactions to explore the displayed data, which standard charts often only limitedly provide. To help improve the understanding of people's voices, we developed and categorized 80 ideas for new visualizations, new interactions, and better connections between different charts, which we present in this report. From those ideas, we implemented 10 prototypes and two systems that integrate different visualizations. We show that this integration allows consistent appearance and behavior of visualizations. The visualizations all share the same main concept: representing each individual with a single dot. To realize this idea, we discuss technologies that efficiently allow the rendering of a large number of these dots. With these visualizations, direct interactions with representations of individuals are achievable by clicking on them or by dragging a selection around them. This direct interaction is only possible with a bidirectional connection from the visualization to the data it displays. We discuss different strategies for bidirectional mappings and the trade-offs involved. Having unified behavior across visualizations enhances exploration. For our prototypes, that includes grouping, filtering, highlighting, and coloring of dots. Our prototyping work was enabled by the development environment Lively4. We explain which parts of Lively4 facilitated our prototyping process. Finally, we evaluate our approach to domain problems and our developed visualization concepts. Our work provides inspiration and a starting point for visualization development in this domain. Our visualizations can improve communication between citizens and their government and motivate empathetic decisions. Our approach, combining low-level entities to create visualizations, provides value to an explorative and empathetic workflow. We show that the design space for visualizing this kind of data has a lot of potential and that it is possible to combine qualitative and quantitative approaches to data analysis. N2 - Der noble Weg, Entscheidungen, die viele Menschen betreffen, zu begründen, besteht darin, diese Menschen nach ihrer Meinung zu fragen. Für Regierungen, die ganze Länder führen, bedeutet dies, alle Bürger nach ihrer Meinung zu fragen, um ihre Situationen und Bedürfnisse zu berücksichtigen. Organisationen wie die Africa's Voices Foundation, die die Kommunikation zwischen Entscheidungsträgern und Bürgern eines Landes erleichtern wollen, haben Schwierigkeiten, zwischen diesen Gruppen zu vermitteln. Um Verständnis zu ermöglichen, müssen die Aussagen zusammengefasst und visualisiert werden. Diese Ziele auf eine Weise zu erreichen, die den Stimmen und Situationen der Bürgerinnen und Bürger gerecht wird, erweist sich als Herausforderung. Standardgrafiken helfen dabei nicht weiter, da es ihnen nicht gelingt, Empathie für die Menschen hinter ihren grafischen Abstraktionen zu schaffen. Darüber hinaus schaffen diese Diagramme kein Vertrauen in die Daten, die sie darstellen, da es keine Möglichkeit gibt, den verwendeten Code und die Originaldaten zu sehen oder zu ihnen zurück zu navigieren. Um diese Funktionen zu erfüllen, würden Visualisierungen sehr von Interaktionen zur Erkundung der angezeigten Daten profitieren, die Standardgrafiken oft nur begrenzt bieten. Um das Verständnis der Stimmen der Menschen zu verbessern, haben wir 80 Ideen für neue Visualisierungen, neue Interaktionen und bessere Verbindungen zwischen verschiedenen Diagrammen entwickelt und kategorisiert, die wir in diesem Bericht vorstellen. Aus diesen Ideen haben wir 10 Prototypen und zwei Systeme implementiert, die verschiedene Visualisierungen integrieren. Wir zeigen, dass diese Integration ein einheitliches Erscheinungsbild und Verhalten der Visualisierungen ermöglicht. Die Visualisierungen haben alle das gleiche Grundkonzept: Jedes Individuum wird durch einen einzigen Punkt dargestellt. Um diese Idee zu verwirklichen, diskutieren wir Technologien, die die effiziente Darstellung einer großen Anzahl dieser Punkte ermöglichen. Mit diesen Visualisierungen sind direkte Interaktionen mit Darstellungen von Individuen möglich, indem man auf sie klickt oder eine Auswahl um sie herumzieht. Diese direkte Interaktion ist nur mit einer bidirektionalen Verbindung von der Visualisierung zu den angezeigten Daten möglich. Wir diskutieren verschiedene Strategien für bidirektionale Mappings und die damit verbundenen Kompromisse. Ein einheitliches Verhalten über Visualisierungen hinweg verbessert die Exploration. Für unsere Prototypen umfasst dies Gruppierung, Filterung, Hervorhebung und Einfärbung von Punkten. Unsere Arbeit an den Prototypen wurde durch die Entwicklungsumgebung Lively4 ermöglicht. Wir erklären, welche Teile von Lively4 unseren Prototyping-Prozess erleichtert haben. Schließlich bewerten wir unsere Herangehensweise an Domänenprobleme und die von uns entwickelten Visualisierungskonzepte. Unsere Arbeit liefert Inspiration und einen Ausgangspunkt für die Entwicklung von Visualisierungen in diesem Bereich. Unsere Visualisierungen können die Kommunikation zwischen Bürgern und ihrer Regierung verbessern und einfühlsame Entscheidungen motivieren. Unser Ansatz, bei dem wir niedrigstufige Entitäten zur Erstellung von Visualisierungen kombinieren, bietet einen wertvollen Ansatz für einen explorativen und einfühlsamen Arbeitsablauf. Wir zeigen, dass der Designraum für die Visualisierung dieser Art von Daten ein großes Potenzial hat und dass es möglich ist, qualitative und quantitative Ansätze zur Datenanalyse zu kombinieren. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 136 KW - data visualization KW - demographic information KW - visualization concept exploration KW - web-based development environment KW - Datenvisualisierung KW - demografische Informationen KW - Visualisierungskonzept-Exploration KW - web-basierte Entwicklungsumgebung Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-491457 SN - 978-3-86956-504-0 SN - 1613-5652 SN - 2191-1665 IS - 136 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schindler, Daniel A1 - Moldenhawer, Ted A1 - Stange, Maike A1 - Lepro, Valentino A1 - Beta, Carsten A1 - Holschneider, Matthias A1 - Huisinga, Wilhelm T1 - Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows JF - PLoS Computational Biology : a new community journal N2 - Amoeboid cell motility is essential for a wide range of biological processes including wound healing, embryonic morphogenesis, and cancer metastasis. It relies on complex dynamical patterns of cell shape changes that pose long-standing challenges to mathematical modeling and raise a need for automated and reproducible approaches to extract quantitative morphological features from image sequences. Here, we introduce a theoretical framework and a computational method for obtaining smooth representations of the spatiotemporal contour dynamics from stacks of segmented microscopy images. Based on a Gaussian process regression we propose a one-parameter family of regularized contour flows that allows us to continuously track reference points (virtual markers) between successive cell contours. We use this approach to define a coordinate system on the moving cell boundary and to represent different local geometric quantities in this frame of reference. In particular, we introduce the local marker dispersion as a measure to identify localized membrane expansions and provide a fully automated way to extract the properties of such expansions, including their area and growth time. The methods are available as an open-source software package called AmoePy, a Python-based toolbox for analyzing amoeboid cell motility (based on time-lapse microscopy data), including a graphical user interface and detailed documentation. Due to the mathematical rigor of our framework, we envision it to be of use for the development of novel cell motility models. We mainly use experimental data of the social amoeba Dictyostelium discoideum to illustrate and validate our approach.
Author summary Amoeboid motion is a crawling-like cell migration that plays an important key role in multiple biological processes such as wound healing and cancer metastasis. This type of cell motility results from expanding and simultaneously contracting parts of the cell membrane. From fluorescence images, we obtain a sequence of points, representing the cell membrane, for each time step. By using regression analysis on these sequences, we derive smooth representations, so-called contours, of the membrane. Since the number of measurements is discrete and often limited, the question is raised of how to link consecutive contours with each other. In this work, we present a novel mathematical framework in which these links are described by regularized flows allowing a certain degree of concentration or stretching of neighboring reference points on the same contour. This stretching rate, the so-called local dispersion, is used to identify expansions and contractions of the cell membrane providing a fully automated way of extracting properties of these cell shape changes. We applied our methods to time-lapse microscopy data of the social amoeba Dictyostelium discoideum. Y1 - 2021 U6 - https://doi.org/10.1371/journal.pcbi.1009268 SN - 1553-734X SN - 1553-7358 VL - 17 IS - 8 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Mattern, Maximilian A1 - Pudell, Jan-Etienne A1 - Laskin, Gennadii A1 - Reppert, Alexander von A1 - Bargheer, Matias T1 - Analysis of the temperature- and fluence-dependent magnetic stress in laser-excited SrRuO3 JF - Structural dynamics N2 - We use ultrafast x-ray diffraction to investigate the effect of expansive phononic and contractive magnetic stress driving the picosecond strain response of a metallic perovskite SrRuO3 thin film upon femtosecond laser excitation. We exemplify how the anisotropic bulk equilibrium thermal expansion can be used to predict the response of the thin film to ultrafast deposition of energy. It is key to consider that the laterally homogeneous laser excitation changes the strain response compared to the near-equilibrium thermal expansion because the balanced in-plane stresses suppress the Poisson stress on the picosecond timescale. We find a very large negative Grüneisen constant describing the large contractive stress imposed by a small amount of energy in the spin system. The temperature and fluence dependence of the strain response for a double-pulse excitation scheme demonstrates the saturation of the magnetic stress in the high-fluence regime. KW - Thin films KW - Thermodynamic properties KW - Bragg peak KW - Ultrafast X-ray diffraction KW - Thermal effects KW - Phonons KW - Magnetism KW - Lattice dynamics KW - Lasers KW - Perovskites Y1 - 2020 U6 - https://doi.org/10.1063/4.0000072 SN - 2329-7778 VL - 8 IS - 2 PB - AIP Publishing LLC CY - Melville, NY ER - TY - JOUR A1 - Oloya, Benson A1 - Namukobe, Jane A1 - Heydenreich, Matthias A1 - Ssengooba, Willy A1 - Schmidt, Bernd A1 - Byamukama, Robert T1 - Antimycobacterial activity of the extract and isolated compounds from the stem bark of Zanthoxylum leprieurii Guill. and Perr. JF - Natural product communications : an international journal for communications and reviews N2 - Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), (S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H(37)Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 mu g/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H(37)Rv) TB strain (MIC 6 mu g/mL), but moderate activity against the MDR-TB strain (MIC 12.2 mu g/mL). Compounds 2, 5, 6, and 1 showed moderate activities against the susceptible (H(37)Rv) strain (MIC 12.2-98.0 mu g/mL) and moderate to weak activities against the MDR-TB strain (MIC 24.4-195.0 mu g/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs. KW - tuberculosis KW - Zanthoxylum leprieurii KW - antimycobacterial activity KW - trans-fagaramide KW - alkaloid Y1 - 2021 U6 - https://doi.org/10.1177/1934578X211035851 SN - 1934-578X SN - 1555-9475 VL - 16 IS - 8 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Bièvre-Perrin, Fabien A1 - Briand, Michel A1 - Jouteur, Isabelle A1 - Pampanay, Élise A1 - Besnard, Tiphaine Annabelle A1 - Costanzo, Daniela A1 - Renault, Manon A1 - Saura-Ziegelmeyer, Arnaud A1 - Scapin, Mathieu A1 - González Vázquez, Mateo A1 - Mihanovic, Andelko ED - Bièvre-Perrin, Fabien ED - Carlà-Uhink, Filippo ED - Rollinger, Christian ED - Walde, Christine T1 - Antiquipop – Chefs d’œuvres revisités T2 - thersites N2 - This special issue hosts the proceedings of a workshop that took place in Lyon in 2019, dedicated to discussing the modern receptions of some "masterpieces" from ancient Greek art. Y1 - 2021 U6 - https://doi.org/10.34679/thersites.vol13 SN - 2364-7612 VL - 2021 IS - 13 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Renault, Manon ED - Bièvre-Perrin, Fabien ED - Carlà-Uhink, Filippo ED - Rollinger, Christian ED - Walde, Christine T1 - Antiquités et pop cultures dans la haute couture et le prêt-à-porter des années 2010 JF - thersites 13: Antiquipop – Chefs d’œuvres revisités N2 - From the fluid dresses woven from precious materials evoking the iconic statues of Antiquity to the revival of Spartan shoes, two emblematic fashion trends will help us study the place of Greek Antiquity in contemporary women’s fashion collections. Ordinary as well as extraordinary, what do these reminiscences tell? Can they permit to understand the boundaries that structure and govern the fashion’s worlds? Numerous and diverse, the differences and the similarities of the ways in which classical references are used allow us to study the relations of power in which the specificities of haute couture and ready-to-wear are defined. The values, the entry criteria, the operating hierarchies as well as the very acceptance of the word “fashion” are different from one environment to another. From the catwalks of big fashion houses on Avenue Montaigne such as Chanel to the youngest brands, the differentiated readings and uses of Antiquity raise the question of the symbolic value of classics in fashion. KW - fashion KW - antiquity KW - sociology KW - Fashion Studies KW - pop culture Y1 - 2021 U6 - https://doi.org/10.34679/thersites.vol13.149 VL - 2021 IS - 13 SP - 125 EP - 140 ER - TY - JOUR A1 - Leinweber, Juliane T1 - App-Einsatz in der Logopädie/Sprachtherapie: Strategien und Kriterien JF - Spektrum Patholinguistik Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510199 SN - 978-3-86956-507-1 SN - 1866-9085 SN - 1866-9433 IS - 14 SP - 69 EP - 76 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Nevill, Alan M. A1 - Negra, Yassine A1 - Myers, Tony D. A1 - Duncan, Michael J. A1 - Chaabene, Helmi A1 - Granacher, Urs T1 - Are Early or Late Maturers Likely to Be Fitter in the General Population? JF - International Journal of Environmental Research and Public Health N2 - The present study aims to identify the optimal body-size/shape and maturity characteristics associated with superior fitness test performances having controlled for body-size, sex, and chronological-age differences. The sample consisted of 597 Tunisian children (396 boys and 201 girls) aged 8 to 15 years. Three sprint speeds recorded at 10, 20 and 30 m; two vertical and two horizontal jump tests; a change-of-direction and a handgrip-strength tests, were assessed during physical-education classes. Allometric modelling was used to identify the benefit of being an early or late maturer. Findings showed that being tall and light is the ideal shape to be successful at most physical fitness tests, but the height-to-weight “shape” ratio seems to be test-dependent. Having controlled for body-size/shape, sex, and chronological age, the model identified maturity-offset as an additional predictor. Boys who go earlier/younger through peak-height-velocity (PHV) outperform those who go at a later/older age. However, most of the girls’ physical-fitness tests peaked at the age at PHV and decline thereafter. Girls whose age at PHV was near the middle of the age range would appear to have an advantage compared to early or late maturers. These findings have important implications for talent scouts and coaches wishing to recruit children into their sports/athletic clubs. KW - youth KW - fitness tests KW - allometry KW - body shape KW - biological age Y1 - 2021 U6 - https://doi.org/10.3390/ijerph18020497 SN - 1660-4601 VL - 18 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schreiber, Alexander A1 - Onea Gáspár, Edgar T1 - Are narrow focus exhaustivity inferences Bayesian inferences? JF - Frontiers in psychology / Frontiers Research Foundation N2 - In successful communication, the literal meaning of linguistic utterances is often enriched by pragmatic inferences. Part of the pragmatic reasoning underlying such inferences has been successfully modeled as Bayesian goal recognition in the Rational Speech Act (RSA) framework. In this paper, we try to model the interpretation of question-answer sequences with narrow focus in the answer in the RSA framework, thereby exploring the effects of domain size and prior probabilities on interpretation. Should narrow focus exhaustivity inferences be actually based on Bayesian inference involving prior probabilities of states, RSA models should predict a dependency of exhaustivity on these factors. We present experimental data that suggest that interlocutors do not act according to the predictions of the RSA model and that exhaustivity is in fact approximately constant across different domain sizes and priors. The results constitute a conceptual challenge for Bayesian accounts of the underlying pragmatic inferences. KW - pragmatics KW - Bayesian models KW - rational speech act models KW - implicatures KW - focus KW - exhaustivity Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.677223 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hahn, Daniela A1 - Weck, Florian A1 - Witthöft, Michael A1 - Kühne, Franziska T1 - Assessment of counseling self-efficacy BT - validation of the German Counselor Activity self-efficacy scales-revised JF - Frontiers in psychology / Frontiers Research Foundation N2 - Background: Many authors regard counseling self-efficacy (CSE) as important in therapist development and training. The purpose of this study was to examine the factor structure, reliability, and validity of the German version of the Counselor Activity Self-Efficacy Scales-Revised (CASES-R). Method: The sample consisted of 670 German psychotherapy trainees, who completed an online survey. We examined the factor structure by applying exploratory and confirmatory factor analysis to the instrument as a whole. Results: A bifactor-exploratory structural equation modeling model with one general and five specific factors provided the best fit to the data. Omega hierarchical coefficients indicated optimal reliability for the general factor, acceptable reliability for the Action Skills-Revised (AS-R) factor, and insufficient estimates for the remaining factors. The CASES-R scales yielded significant correlations with related measures, but also with therapeutic orientations. Conclusion: We found support for the reliability and validity of the German CASES-R. However, the subdomains (except AS-R) should be interpreted with caution, and we do not recommend the CASES-R for comparisons between psychotherapeutic orientations. KW - counselor activity self-efficacy scales KW - counseling self-efficacy KW - psychotherapy training KW - assessment KW - factor structure KW - validation Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.780088 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Dech, Silas A1 - Bittmann, Frank A1 - Schaefer, Laura T1 - Assessment of the adaptive force of Elbow extensors in healthy subjects quantified by a novel pneumatically driven measurement system with considerations of its quality criteria JF - Diagnostics : open access journal N2 - Adaptive Force (AF) reflects the capability of the neuromuscular system to adapt adequately to external forces with the intention of maintaining a position or motion. One specific approach to assessing AF is to measure force and limb position during a pneumatically applied increasing external force. Through this method, the highest (AFmax), the maximal isometric (AFisomax) and the maximal eccentric Adaptive Force (AFeccmax) can be determined. The main question of the study was whether the AFisomax is a specific and independent parameter of muscle function compared to other maximal forces. In 13 healthy subjects (9 male and 4 female), the maximal voluntary isometric contraction (pre- and post-MVIC), the three AF parameters and the MVIC with a prior concentric contraction (MVICpri-con) of the elbow extensors were measured 4 times on two days. Arithmetic mean (M) and maximal (Max) torques of all force types were analyzed. Regarding the reliability of the AF parameters between days, the mean changes were 0.31–1.98 Nm (0.61%–5.47%, p = 0.175–0.552), the standard errors of measurements (SEM) were 1.29–5.68 Nm (2.53%–15.70%) and the ICCs(3,1) = 0.896–0.996. M and Max of AFisomax, AFmax and pre-MVIC correlated highly (r = 0.85–0.98). The M and Max of AFisomax were significantly lower (6.12–14.93 Nm; p ≤ 0.001–0.009) and more variable between trials (coefficient of variation (CVs) ≥ 21.95%) compared to those of pre-MVIC and AFmax (CVs ≤ 5.4%). The results suggest the novel measuring procedure is suitable to reliably quantify the AF, whereby the presented measurement errors should be taken into consideration. The AFisomax seems to reflect its own strength capacity and should be detected separately. It is suggested its normalization to the MVIC or AFmax could serve as an indicator of a neuromuscular function. KW - adaptive force KW - sensorimotor control KW - isometric muscle action KW - eccentric muscle action KW - maximal voluntary contraction KW - adaptive holding capacity KW - reliability KW - validity KW - neuromuscular functionality Y1 - 2021 U6 - https://doi.org/10.3390/diagnostics11060923 SN - 2075-4418 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Sariati, Dorsaf A1 - Zouhal, Hassane A1 - Hammami, Raouf A1 - Clark, Cain Craig Truman A1 - Nebigh, Ammar A1 - Chtara, Moktar A1 - Hackney, Anthony C. A1 - Souissi, Nizar A1 - Granacher, Urs A1 - Ben Ounis, Omar T1 - Association Between Mental Imagery and Change of Direction Performance in Young Elite Soccer Players of Different Maturity Status JF - Frontiers in Psychology N2 - Previous studies have not considered the potential influence of maturity status on the relationship between mental imagery and change of direction (CoD) speed in youth soccer. Accordingly, this cross-sectional study examined the association between mental imagery and CoD performance in young elite soccer players of different maturity status. Forty young male soccer players, aged 10-17 years, were assigned into two groups according to their predicted age at peak height velocity (PHV) (Pre-PHV; n = 20 and Post-PHV; n = 20). Participants were evaluated on soccer-specific tests of CoD with (CoDBall-15m) and without (CoD-15m) the ball. Participants completed the movement imagery questionnaire (MIQ) with the three- dimensional structure, internal visual imagery (IVI), external visual imagery (EVI), as well as kinesthetic imagery (KI). The Post-PHV players achieved significantly better results than Pre-PHV in EVI (ES = 1.58, large; p < 0.001), CoD-15m (ES = 2.09, very large; p < 0.001) and CoDBall-15m (ES = 1.60, large; p < 0.001). Correlations were significantly different between maturity groups, where, for the pre-PHV group, a negative very large correlation was observed between CoDBall-15m and KI (r = –0.73, p = 0.001). For the post-PHV group, large negative correlations were observed between CoD-15m and IVI (r = –0.55, p = 0.011), EVI (r = –062, p = 0.003), and KI (r = –0.52, p = 0.020). A large negative correlation of CoDBall-15m with EVI (r = –0.55, p = 0.012) and very large correlation with KI (r = –0.79, p = 0.001) were also observed. This study provides evidence of the theoretical and practical use for the CoD tasks stimulus with imagery. We recommend that sport psychology specialists, coaches, and athletes integrated imagery for CoD tasks in pre-pubertal soccer players to further improve CoD related performance. KW - mental imagery KW - football KW - maturation KW - speed KW - adolescents Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.665508 SN - 1664-1078 VL - 12 SP - 1 EP - 9 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Grüner, Andreas A1 - Mühle, Alexander A1 - Meinel, Christoph T1 - ATIB BT - Design and evaluation of an architecture for brokered self-sovereign identity integration and trust-enhancing attribute aggregation for service provider JF - IEEE access : practical research, open solutions / Institute of Electrical and Electronics Engineers N2 - Identity management is a principle component of securing online services. In the advancement of traditional identity management patterns, the identity provider remained a Trusted Third Party (TTP). The service provider and the user need to trust a particular identity provider for correct attributes amongst other demands. This paradigm changed with the invention of blockchain-based Self-Sovereign Identity (SSI) solutions that primarily focus on the users. SSI reduces the functional scope of the identity provider to an attribute provider while enabling attribute aggregation. Besides that, the development of new protocols, disregarding established protocols and a significantly fragmented landscape of SSI solutions pose considerable challenges for an adoption by service providers. We propose an Attribute Trust-enhancing Identity Broker (ATIB) to leverage the potential of SSI for trust-enhancing attribute aggregation. Furthermore, ATIB abstracts from a dedicated SSI solution and offers standard protocols. Therefore, it facilitates the adoption by service providers. Despite the brokered integration approach, we show that ATIB provides a high security posture. Additionally, ATIB does not compromise the ten foundational SSI principles for the users. KW - Blockchains KW - Protocols KW - Authentication KW - Licenses KW - Security KW - Privacy KW - Identity management systems KW - Attribute aggregation KW - attribute assurance KW - digital identity KW - identity broker KW - self-sovereign identity KW - trust model Y1 - 2021 U6 - https://doi.org/10.1109/ACCESS.2021.3116095 SN - 2169-3536 VL - 9 SP - 138553 EP - 138570 PB - Institute of Electrical and Electronics Engineers CY - New York, NY ER - TY - JOUR A1 - Paton, Eva A1 - Vogel, Johannes Joscha A1 - Kluge, Björn A1 - Nehls, Thomas T1 - Ausmaß, Trend und Extrema von Dürren im urbanen Raum T1 - Extent, trend and extremes of droughts in urban areas JF - Hydrologie und Wasserbewirtschaftung N2 - Summers are currently perceived to be getting longer, hotter and more extreme - and this impression is reinforced in urban areas by the occurrence of heat island effects in densely built-up areas. To assess the real extent of increasing drought occurrences in German cities, a DWD data set of 31 urban climate stations for the period 1950 to 2019 was analysed using the standardised precipitation index (SPI) with regard to meteorological drought lengths, drought extrema, heat waves and compound events in the form of simultaneously occurring heat waves and drought months. The analysis shows a large degree of heterogeneity within Germany: a severe drought occurred in most cities in 2018, while the year 2018 was among the three years with the longest droughts (since 1950) for only one third of the cities. Some southern and central German cities show a statistically significant increase in drought months per decade since 1950, other cities, mostly in the north and northwest, only show an increase in the past two decades or even no trend at all. The compound analysis of simultaneously occurring heat and drought months shows a strong increase at most stations in the last two decades, whereby the two components are responsible with a very different proportion regionally for the increase in compound events. N2 - In der derzeitigen Wahrnehmung werden die Sommer dürrer, heißer und extremer – dieser Eindruck verstärkt sich im urbanen Raum durch das Auftreten von Hitzeinseleffekten in dicht bebauten Gebieten. Um das wirkliche Ausmaß der Dürre bewerten zu können, wurden Zeitreihendaten von 31 urbanen Klimastationen (DWD) für den Zeitraum 1950 bis 2019 mittels des standardisierten Niederschlagsindex (SPI) bezüglich Dürrelängen, Dürreextrema, Hitzewellen und gleichzeitig auftretenden Hitze- und Dürremonaten ausgewertet. Die Analyse zeigt eine große Heterogenität innerhalb von Deutschland: In den meisten Städten trat 2018 eine lange Dürre von einer durchschnittlichen Dauer von 6 Monaten auf, gleichzeitig gehörte das Jahr 2018 nur bei einem Drittel der Städte zu den drei Jahren mit den längsten Dürren seit 1950. Bei den meisten betrachteten Stationen traten die längsten Dürren in den Jahren 1953, 1971 und 1976 auf. Bei einigen südlichen und mitteldeutschen Städten kann man eine statistisch signifikante Zunahme der Anzahl der Dürremonate pro Dekade seit 1950 verzeichnen. Andere Städte, eher im Norden und Nordwesten gelegen, zeigen nur in den letzten zwei Dekaden eine Zunahme oder gar keinen Trend. Die Compoundanalyse von gleichzeitig auftretenden Hitze- und Dürremonaten zeigt bei den meisten Stationen eine starke Zunahme innerhalb der letzten zwei Dekaden, wobei die beiden Komponenten regional mit einem sehr unterschiedlichen Anteil zur Zunahme der Compoundereignisse beitragen. KW - meteorological droughts KW - heat waves KW - compound events KW - standardised KW - precipitation index (SPI) KW - urban hydrology KW - meteorologische Dürren KW - Hitzewellen KW - Compoundereignisse KW - standardisierter Niederschlagsindex (SPI KW - urbane Hydrologie Y1 - 2021 U6 - https://doi.org/10.5675/HyWa_2021.1_1 SN - 1439-1783 SN - 2749-859X VL - 65 IS - 1 SP - 5 EP - 16 PB - Bundesanstalt für Gewässerkunde CY - Koblenz ER - TY - JOUR A1 - Tranter, Morgan Alan A1 - De Lucia, Marco A1 - Kühn, Michael T1 - Barite scaling potential modelled for fractured-porous geothermal reservoirs JF - Minerals N2 - Barite scalings are a common cause of permanent formation damage to deep geothermal reservoirs. Well injectivity can be impaired because the ooling of saline fluids reduces the solubility of barite, and the continuous re-injection of supersaturated fluids forces barite to precipitate in the host rock. Stimulated reservoirs in the Upper Rhine Graben often have multiple relevant flow paths in the porous matrix and fracture zones, sometimes spanning multiple stratigraphical units to achieve the economically necessary injectivity. While the influence of barite scaling on injectivity has been investigated for purely porous media, the role of fractures within reservoirs consisting of both fractured and porous sections is still not well understood. Here, we present hydro-chemical simulations of a dual-layer geothermal reservoir to study the long-term impact of barite scale formation on well injectivity. Our results show that, compared to purely porous reservoirs, fractured porous reservoirs have a significantly reduced scaling risk by up to 50%, depending on the flow rate ratio of fractures. Injectivity loss is doubled, however, if the amount of active fractures is increased by one order of magnitude, while the mean fracture aperture is decreased, provided the fractured aquifer dictates the injection rate. We conclude that fractured, and especially hydraulically stimulated, reservoirs are generally less affected by barite scaling and that large, but few, fractures are favourable. We present a scaling score for fractured-porous reservoirs, which is composed of easily derivable quantities such as the radial equilibrium length and precipitation potential. This score is suggested for use approximating the scaling potential and its impact on injectivity of a fractured-porous reservoir for geothermal exploitation. KW - reactive transport KW - radial flow KW - geothermal energy KW - injectivity KW - phreeqc KW - formation damage Y1 - 2021 U6 - https://doi.org/10.3390/min11111198 SN - 2075-163X VL - 11 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Han, Sungju A1 - Kuhlicke, Christian T1 - Barriers and drivers for mainstreaming nature-based solutions for flood risks BT - the case of South Korea JF - International journal of disaster risk science N2 - Nature-based solutions (NBS) are seen as a promising adaptation measure that sustainably deals with diverse societal challenges, while simultaneously delivering multiple benefits. Nature-based solutions have been highlighted as a resilient and sustainable means of mitigating floods and other hazards globally. This study examined diverging conceptualizations of NBS, as well as the attitudinal (for example, emotions and beliefs) and contextual (for example, legal and political aspects) barriers and drivers of NBS for flood risks in South Korea. Semistructured interviews were conducted with 11 experts and focused on the topic of flood risk measures and NBS case studies. The analysis found 11 barriers and five drivers in the attitudinal domain, and 13 barriers and two drivers in the contextual domain. Most experts see direct monetary benefits as an important attitudinal factor for the public. Meanwhile, the cost-effectiveness of NBS and their capacity to cope with flood risks were deemed influential factors that could lead decision makers to opt for NBS. Among the contextual factors, insufficient systems to integrate NBS in practice and the ideologicalization of NBS policy were found to be peculiar barriers, which hinder consistent realization of initiatives and a long-term national plan for NBS. Understanding the barriers and drivers related to the mainstreaming of NBS is critical if we are to make the most of such solutions for society and nature. It is also essential that we have a shared definition, expectation, and vision of NBS. KW - climate change KW - flood risk management KW - nature-based solutions (NBS) KW - South Korea Y1 - 2021 U6 - https://doi.org/10.1007/s13753-021-00372-4 SN - 2095-0055 SN - 2192-6395 VL - 12 IS - 5 SP - 661 EP - 672 PB - Springer CY - New York ER - TY - JOUR A1 - Lindborg, Alma A1 - Andersen, Tobias S. T1 - Bayesian binding and fusion models explain illusion and enhancement effects in audiovisual speech perception JF - PLoS one N2 - Speech is perceived with both the ears and the eyes. Adding congruent visual speech improves the perception of a faint auditory speech stimulus, whereas adding incongruent visual speech can alter the perception of the utterance. The latter phenomenon is the case of the McGurk illusion, where an auditory stimulus such as e.g. "ba" dubbed onto a visual stimulus such as "ga" produces the illusion of hearing "da". Bayesian models of multisensory perception suggest that both the enhancement and the illusion case can be described as a two-step process of binding (informed by prior knowledge) and fusion (informed by the information reliability of each sensory cue). However, there is to date no study which has accounted for how they each contribute to audiovisual speech perception. In this study, we expose subjects to both congruent and incongruent audiovisual speech, manipulating the binding and the fusion stages simultaneously. This is done by varying both temporal offset (binding) and auditory and visual signal-to-noise ratio (fusion). We fit two Bayesian models to the behavioural data and show that they can both account for the enhancement effect in congruent audiovisual speech, as well as the McGurk illusion. This modelling approach allows us to disentangle the effects of binding and fusion on behavioural responses. Moreover, we find that these models have greater predictive power than a forced fusion model. This study provides a systematic and quantitative approach to measuring audiovisual integration in the perception of the McGurk illusion as well as congruent audiovisual speech, which we hope will inform future work on audiovisual speech perception. Y1 - 2021 U6 - https://doi.org/10.1371/journal.pone.0246986 SN - 1932-6203 VL - 16 IS - 2 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Şahin, Muhittin A1 - Egloffstein, Marc A1 - Bothe, Max A1 - Rohloff, Tobias A1 - Schenk, Nathanael A1 - Schwerer, Florian A1 - Ifenthaler, Dirk T1 - Behavioral Patterns in Enterprise MOOCs at openSAP JF - EMOOCs 2021 Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-517350 SN - 978-3-86956-512-5 VL - 2021 SP - 281 EP - 288 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Brandes, Stefanie A1 - Sicks, Florian A1 - Berger, Anne T1 - Behaviour classification on giraffes (Giraffa camelopardalis) using machine learning algorithms on triaxial acceleration data of two commonly used GPS devices and its possible application for their management and conservation JF - Sensors N2 - Averting today's loss of biodiversity and ecosystem services can be achieved through conservation efforts, especially of keystone species. Giraffes (Giraffa camelopardalis) play an important role in sustaining Africa's ecosystems, but are 'vulnerable' according to the IUCN Red List since 2016. Monitoring an animal's behavior in the wild helps to develop and assess their conservation management. One mechanism for remote tracking of wildlife behavior is to attach accelerometers to animals to record their body movement. We tested two different commercially available high-resolution accelerometers, e-obs and Africa Wildlife Tracking (AWT), attached to the top of the heads of three captive giraffes and analyzed the accuracy of automatic behavior classifications, focused on the Random Forests algorithm. For both accelerometers, behaviors of lower variety in head and neck movements could be better predicted (i.e., feeding above eye level, mean prediction accuracy e-obs/AWT: 97.6%/99.7%; drinking: 96.7%/97.0%) than those with a higher variety of body postures (such as standing: 90.7-91.0%/75.2-76.7%; rumination: 89.6-91.6%/53.5-86.5%). Nonetheless both devices come with limitations and especially the AWT needs technological adaptations before applying it on animals in the wild. Nevertheless, looking at the prediction results, both are promising accelerometers for behavioral classification of giraffes. Therefore, these devices when applied to free-ranging animals, in combination with GPS tracking, can contribute greatly to the conservation of giraffes. KW - giraffe KW - triaxial acceleration KW - machine learning KW - random forests KW - behavior classification KW - giraffe conservation Y1 - 2021 U6 - https://doi.org/10.3390/s21062229 SN - 1424-8220 VL - 21 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Baumgardt, Iris T1 - Berufliche Orientierung von Kindern im Grundschulalter BT - Analyse von ausgewählten Projekten, Unterrichtsmaterialien und Lehrplänen N2 - Die berufliche Orientierung von Kindern im Grundschulalter ist bislang nur in Ansätzen erforscht. Gleichwohl gibt es berufsorientierende Angebote, die auf verschiedenen Ebenen Grundschulkinder adressieren. Die Untersuchung fokussiert aktuelle Forschungsergebnisse, ausgewählte Initiativen, Kinderbücher, Unterrichtsmaterialien usw. zur beruflichen Orientierung von Kindern. Mit dem Ziel der Entwicklung und Ausdifferenzierung eines facettenreichen beruflichen Selbstkonzeptes von Kindern werden spezifische Forschungs- und Entwicklungspotenziale aufgezeigt. Y1 - 2022 SN - 978-3-8340-2199-1 SN - 978-3-7639-7188-6 U6 - https://doi.org/10.3278/9783763971886 PB - Schneider Verlag Hohengehren GmbH CY - Baltmannsweiler ER - TY - BOOK A1 - Ganghof, Steffen T1 - Beyond Presidentialism and Parliamentarism BT - Democratic Design and the Separation of Powers N2 - In a democracy, a constitutional separation of powers between the executive and the assembly may be desirable, but the constitutional concentration of executive power in a single human being is not. The book defends this thesis and explores ‘semi-parliamentary government’ as an alternative to presidential government. Semi-parliamentarism avoids power concentration in one person by shifting the separation of powers into the democratic assembly. The executive becomes fused with only one part of the assembly, even though the other part has at least equal democratic legitimacy and robust veto power on ordinary legislation. The book identifies the Australian Commonwealth and Japan, as well as the Australian states of New South Wales, South Australia, Tasmania, Victoria, and Western Australia, as semi-parliamentary systems. Using data from 23 countries and 6 Australian states, it maps how parliamentary and semi-parliamentary systems balance competing visions of democracy; it analyzes patterns of electoral and party systems, cabinet formation, legislative coalition-building, and constitutional reforms; it systematically compares the semi-parliamentary and presidential separation of powers; and it develops new and innovative semi-parliamentary designs, some of which do not require two separate chambers. KW - presidential government KW - parliamentary government KW - semi-parliamentary government KW - separation of powers KW - executive personalism KW - bicameralism KW - constitutional design KW - democratic theory KW - patterns of democracy KW - Australia Y1 - 2021 SN - 978-0-19-289714-5 U6 - https://doi.org/10.1093/oso/9780192897145.001.0001 SP - 1 EP - 199 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Purinton, Benjamin A1 - Bookhagen, Bodo T1 - Beyond Vertical Point Accuracy BT - Assessing Inter-pixel Consistency in 30 m Global DEMs for the Arid Central Andes JF - Frontiers in Earth Science N2 - Quantitative geomorphic research depends on accurate topographic data often collected via remote sensing. Lidar, and photogrammetric methods like structure-from-motion, provide the highest quality data for generating digital elevation models (DEMs). Unfortunately, these data are restricted to relatively small areas, and may be expensive or time-consuming to collect. Global and near-global DEMs with 1 arcsec (∼30 m) ground sampling from spaceborne radar and optical sensors offer an alternative gridded, continuous surface at the cost of resolution and accuracy. Accuracy is typically defined with respect to external datasets, often, but not always, in the form of point or profile measurements from sources like differential Global Navigation Satellite System (GNSS), spaceborne lidar (e.g., ICESat), and other geodetic measurements. Vertical point or profile accuracy metrics can miss the pixel-to-pixel variability (sometimes called DEM noise) that is unrelated to true topographic signal, but rather sensor-, orbital-, and/or processing-related artifacts. This is most concerning in selecting a DEM for geomorphic analysis, as this variability can affect derivatives of elevation (e.g., slope and curvature) and impact flow routing. We use (near) global DEMs at 1 arcsec resolution (SRTM, ASTER, ALOS, TanDEM-X, and the recently released Copernicus) and develop new internal accuracy metrics to assess inter-pixel variability without reference data. Our study area is in the arid, steep Central Andes, and is nearly vegetation-free, creating ideal conditions for remote sensing of the bare-earth surface. We use a novel hillshade-filtering approach to detrend long-wavelength topographic signals and accentuate short-wavelength variability. Fourier transformations of the spatial signal to the frequency domain allows us to quantify: 1) artifacts in the un-projected 1 arcsec DEMs at wavelengths greater than the Nyquist (twice the nominal resolution, so > 2 arcsec); and 2) the relative variance of adjacent pixels in DEMs resampled to 30-m resolution (UTM projected). We translate results into their impact on hillslope and channel slope calculations, and we highlight the quality of the five DEMs. We find that the Copernicus DEM, which is based on a carefully edited commercial version of the TanDEM-X, provides the highest quality landscape representation, and should become the preferred DEM for topographic analysis in areas without sufficient coverage of higher-quality local DEMs. KW - DEM noise KW - Fourier analysis KW - TanDEM-X KW - ASTER GDEM KW - Copernicus DEM KW - WorldDEM KW - SRTM KW - ALOS World 3D Y1 - 2021 U6 - https://doi.org/10.3389/feart.2021.758606 SN - 2296-6463 SP - 1 EP - 24 PB - Frontiers Media CY - Lausanne, Schweiz ER - TY - JOUR A1 - Hampf, Anna A1 - Nendel, Claas A1 - Strey, Simone A1 - Strey, Robert T1 - Biotic yield losses in the Southern Amazon, Brazil BT - making use of smartphone-assisted plant disease diagnosis data JF - Frontiers in plant science : FPLS N2 - Pathogens and animal pests (P&A) are a major threat to global food security as they directly affect the quantity and quality of food. The Southern Amazon, Brazil's largest domestic region for soybean, maize and cotton production, is particularly vulnerable to the outbreak of P&A due to its (sub)tropical climate and intensive farming systems. However, little is known about the spatial distribution of P&A and the related yield losses. Machine learning approaches for the automated recognition of plant diseases can help to overcome this research gap. The main objectives of this study are to (1) evaluate the performance of Convolutional Neural Networks (ConvNets) in classifying P&A, (2) map the spatial distribution of P&A in the Southern Amazon, and (3) quantify perceived yield and economic losses for the main soybean and maize P&A. The objectives were addressed by making use of data collected with the smartphone application Plantix. The core of the app's functioning is the automated recognition of plant diseases via ConvNets. Data on expected yield losses were gathered through a short survey included in an "expert" version of the application, which was distributed among agronomists. Between 2016 and 2020, Plantix users collected approximately 78,000 georeferenced P&A images in the Southern Amazon. The study results indicate a high performance of the trained ConvNets in classifying 420 different crop-disease combinations. Spatial distribution maps and expert-based yield loss estimates indicate that maize rust, bacterial stalk rot and the fall armyworm are among the most severe maize P&A, whereas soybean is mainly affected by P&A like anthracnose, downy mildew, frogeye leaf spot, stink bugs and brown spot. Perceived soybean and maize yield losses amount to 12 and 16%, respectively, resulting in annual yield losses of approximately 3.75 million tonnes for each crop and economic losses of US$2 billion for both crops together. The high level of accuracy of the trained ConvNets, when paired with widespread use from following a citizen-science approach, results in a data source that will shed new light on yield loss estimates, e.g., for the analysis of yield gaps and the development of measures to minimise them. KW - plant pathology KW - animal pests KW - pathogens KW - machine learning KW - digital KW - image processing KW - disease diagnosis KW - crowdsourcing KW - crop losses Y1 - 2021 U6 - https://doi.org/10.3389/fpls.2021.621168 SN - 1664-462X VL - 12 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Miklashevsky, Alex A1 - Kulkova, Elena A1 - Michirev, Alexej A1 - Jeglinski-Mende, Melinda A. A1 - Bertonatti, Matias T1 - Book review on: Raab, Markus: Judgment, decision-making, and embodied choices. - London ; San Diego ; Cambridge, MA ; Oxford: Academic Press, 2020. - xv, 155 pages. - ISBN: 978-0-12-823523-2 JF - Frontiers in psychology KW - embodied cognition KW - decision making KW - embodied choice KW - book review KW - mind-body Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.665728 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Ulbricht, Alexander A1 - Mohr, Gunther A1 - Altenburg, Simon J. A1 - Oster, Simon A1 - Maierhofer, Christiane A1 - Bruno, Giovanni T1 - Can potential defects in LPBF be healed from the laser exposure of subsequent layers? BT - A quantitative study JF - Metals : open access journal N2 - Additive manufacturing (AM) of metals and in particular laser powder bed fusion (LPBF) enables a degree of freedom in design unparalleled by conventional subtractive methods. To ensure that the designed precision is matched by the produced LPBF parts, a full understanding of the interaction between the laser and the feedstock powder is needed. It has been shown that the laser also melts subjacent layers of material underneath. This effect plays a key role when designing small cavities or overhanging structures, because, in these cases, the material underneath is feed-stock powder. In this study, we quantify the extension of the melt pool during laser illumination of powder layers and the defect spatial distribution in a cylindrical specimen. During the LPBF process, several layers were intentionally not exposed to the laser beam at various locations, while the build process was monitored by thermography and optical tomography. The cylinder was finally scanned by X-ray computed tomography (XCT). To correlate the positions of the unmolten layers in the part, a staircase was manufactured around the cylinder for easier registration. The results show that healing among layers occurs if a scan strategy is applied, where the orientation of the hatches is changed for each subsequent layer. They also show that small pores and surface roughness of solidified material below a thick layer of unmolten material (>200 mu m) serve as seeding points for larger voids. The orientation of the first two layers fully exposed after a thick layer of unmolten powder shapes the orientation of these voids, created by a lack of fusion. KW - selective laser melting (SLM) KW - additive manufacturing (AM) KW - process KW - monitoring KW - infrared thermography KW - optical tomography KW - X-ray computed KW - tomography (XCT) KW - healing KW - in situ monitoring Y1 - 2021 U6 - https://doi.org/10.3390/met11071012 SN - 2075-4701 VL - 11 IS - 7 PB - MDPI CY - Basel ER - TY - JOUR A1 - Block, Inga A1 - Günter, Christina A1 - Rodrigues, Alysson Duarte A1 - Paasch, Silvia A1 - Hesemann, Peter A1 - Taubert, Andreas T1 - Carbon Adsorbents from Spent Coffee for Removal of Methylene Blue and Methyl Orange from Water JF - Materials N2 - Activated carbons (ACs) were prepared from dried spent coffee (SCD), a biological waste product, to produce adsorbents for methylene blue (MB) and methyl orange (MO) from aqueous solution. Pre-pyrolysis activation of SCD was achieved via treatment of the SCD with aqueous sodium hydroxide solutions at 90 °C. Pyrolysis of the pretreated SCD at 500 °C for 1 h produced powders with typical characteristics of AC suitable and effective for dye adsorption. As an alternative to the rather harsh base treatment, calcium carbonate powder, a very common and abundant resource, was also studied as an activator. Mixtures of SCD and CaCO3 (1:1 w/w) yielded effective ACs for MO and MB removal upon pyrolysis needing only small amounts of AC to clear the solutions. A selectivity of the adsorption process toward anionic (MO) or cationic (MB) dyes was not observed. KW - water KW - spent coffee KW - dye adsorption KW - methylene blue KW - methyl orange KW - calcium carbonate KW - activated carbon KW - water treatment KW - dye removal Y1 - 2021 U6 - https://doi.org/10.3390/ma14143996 SN - 1996-1944 VL - 14 IS - 14 PB - MDPI CY - Basel ER - TY - JOUR A1 - Salzwedel, Annett A1 - Völler, Heinz T1 - Cardiac rehabilitation BT - patient-reported outcomes are decisive for success JF - Deutsches Ärzteblatt international : a weekly online journal of clinical medicine and public health Y1 - 2021 U6 - https://doi.org/10.3238/arztebl.m2021.0211 SN - 1866-0452 VL - 118 IS - 29-30 SP - 505 EP - 506 PB - Dt. Ärzte-Verl. CY - Cologne ER - TY - JOUR A1 - Pathe-Neuschäfer-Rube, Andrea A1 - Neuschäfer-Rube, Frank A1 - Püschel, Gerhard Paul T1 - Cell-based reporter release assay to determine the activity of calcium-dependent neurotoxins and neuroactive pharmaceuticals JF - Toxins / Molecular Diversity Preservation International (MDPI) N2 - The suitability of a newly developed cell-based functional assay was tested for the detection of the activity of a range of neurotoxins and neuroactive pharmaceuticals which act by stimulation or inhibition of calcium-dependent neurotransmitter release. In this functional assay, a reporter enzyme is released concomitantly with the neurotransmitter from neurosecretory vesicles. The current study showed that the release of a luciferase from a differentiated human neuroblastoma-based reporter cell line (SIMA-hPOMC1-26-GLuc cells) can be stimulated by a carbachol-mediated activation of the Gq-coupled muscarinic-acetylcholine receptor and by the Ca2+-channel forming spider toxin α-latrotoxin. Carbachol-stimulated luciferase release was completely inhibited by the muscarinic acetylcholine receptor antagonist atropine and α-latrotoxin-mediated release by the Ca2+-chelator EGTA, demonstrating the specificity of luciferase-release stimulation. SIMA-hPOMC1-26-GLuc cells express mainly L- and N-type and to a lesser extent T-type VGCC on the mRNA and protein level. In accordance with the expression profile a depolarization-stimulated luciferase release by a high K+-buffer was effectively and dose-dependently inhibited by L-type VGCC inhibitors and to a lesser extent by N-type and T-type inhibitors. P/Q- and R-type inhibitors did not affect the K+-stimulated luciferase release. In summary, the newly established cell-based assay may represent a versatile tool to analyze the biological efficiency of a range of neurotoxins and neuroactive pharmaceuticals which mediate their activity by the modulation of calcium-dependent neurotransmitter release. KW - cell-based assay KW - neurotoxins KW - muscarinic acetylcholine receptor KW - voltage-dependent calcium channels KW - VGCC Y1 - 2021 U6 - https://doi.org/10.3390/toxins13040247 SN - 2072-6651 VL - 13 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Wardelmann, Kristina A1 - Rath, Michaela A1 - Castro, José Pedro A1 - Blümel, Sabine A1 - Schell, Mareike A1 - Hauffe, Robert A1 - Schumacher, Fabian A1 - Flore, Tanina A1 - Ritter, Katrin A1 - Wernitz, Andreas A1 - Hosoi, Toru A1 - Ozawa, Koichiro A1 - Kleuser, Burkhard A1 - Weiß, Jürgen A1 - Schürmann, Annette A1 - Kleinridders, André T1 - Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism and insulin sensitivity in the hypothalamus JF - Antioxidants N2 - Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin signaling. Although insulin activates this response and improves metabolism, the metabolic impact of one of its members, the mitochondrial chaperone heat shock protein 10 (Hsp10), is unknown. Thus, we hypothesized that a reduction of Hsp10 in hypothalamic neurons will impair mitochondrial function and impact brain insulin action. Therefore, we investigated the role of chaperone Hsp10 by introducing a lentiviral-mediated Hsp10 knockdown (KD) in the hypothalamic cell line CLU-183 and in the arcuate nucleus (ARC) of C57BL/6N male mice. We analyzed mitochondrial function and insulin signaling utilizing qPCR, Western blot, XF96 Analyzer, immunohistochemistry, and microscopy techniques. We show that Hsp10 expression is reduced in T2D mice brains and regulated by leptin in vitro. Hsp10 KD in hypothalamic cells induced mitochondrial dysfunction with altered fatty acid metabolism and increased mitochondria-specific oxidative stress resulting in neuronal insulin resistance. Consequently, the reduction of Hsp10 in the ARC of C57BL/6N mice caused hypothalamic insulin resistance with acute liver insulin resistance. KW - brain insulin signaling KW - mitochondria KW - oxidative stress KW - fatty acid metabolism Y1 - 2021 U6 - https://doi.org/10.3390/antiox10050711 SN - 2076-3921 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Pitzen, Valentin A1 - Sander, Sophia A1 - Baumann, Otto A1 - Gräf, Ralph A1 - Meyer, Irene T1 - Cep192, a novel missing link between the centrosomal core and corona in Dictyostelium amoebae JF - Cells : open access journal N2 - The Dictyostelium centrosome is a nucleus-associated body with a diameter of approx. 500 nm. It contains no centrioles but consists of a cylindrical layered core structure surrounded by a microtubule-nucleating corona. At the onset of mitosis, the corona disassembles and the core structure duplicates through growth, splitting, and reorganization of the outer core layers. During the last decades our research group has characterized the majority of the 42 known centrosomal proteins. In this work we focus on the conserved, previously uncharacterized Cep192 protein. We use superresolution expansion microscopy (ExM) to show that Cep192 is a component of the outer core layers. Furthermore, ExM with centrosomal marker proteins nicely mirrored all ultrastructurally known centrosomal substructures. Furthermore, we improved the proximity-dependent biotin identification assay (BioID) by adapting the biotinylase BioID2 for expression in Dictyostelium and applying a knock-in strategy for the expression of BioID2-tagged centrosomal fusion proteins. Thus, we were able to identify various centrosomal Cep192 interaction partners, including CDK5RAP2, which was previously allocated to the inner corona structure, and several core components. Studies employing overexpression of GFP-Cep192 as well as depletion of endogenous Cep192 revealed that Cep192 is a key protein for the recruitment of corona components during centrosome biogenesis and is required to maintain a stable corona structure. KW - Cep192 KW - SPD-2 KW - centrosome KW - Dictyostelium KW - microtubule-organization KW - MTOC Y1 - 2021 U6 - https://doi.org/10.3390/cells10092384 SN - 2073-4409 VL - 10 IS - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Otter, Dirk A1 - Mondal, Suvendu Sekhar A1 - Alrefai, Anas A1 - Krätz, Lorenz A1 - Holdt, Hans-Jürgen A1 - Bart, Hans-Jörg T1 - Characterization of an isostructural MOF series of Imidazolate Frameworks Potsdam by means of sorption experiments with water vapor JF - Nanomaterials N2 - Sorption measurements of water vapor on an isoreticular series of Imidazolate Frameworks Potsdam (IFP), based on penta-coordinated metal centers with secondary building units (SBUs) connected by multidentate amido-imidate-imidazolate linkers, have been carried out at 303.15 K. The isotherm shapes were analyzed in order to gain insight into material properties and compared to sorption experiments with nitrogen at 77.4 K and carbon dioxide at 273.15 K. Results show that water vapor sorption measurements are strongly influenced by the pore size distribution while having a distinct hysteresis loop between the adsorption and desorption branch in common. Thus, IFP-4 and -8, which solely contain micropores, exhibit H4 (type I) isotherm shapes, while those of IFP-1, -2 and -5, which also contain mesopores, are of H3 (type IV) shape with three inflection points. The choice of the used linker substituents and transition metals employed in the framework has a tremendous effect on the material properties and functionality. The water uptake capacities of the examined IFPs are ranging 0.48 mmol g(-1) (IFP-4) to 6.99 mmol g(-1) (IFP-5) and comparable to those documented for ZIFs. The water vapor stability of IFPs is high, with the exception of IFP-8. KW - material characterization KW - water vapor KW - adsorption KW - hysteresis KW - Imidazolate Frameworks Potsdam Y1 - 2021 U6 - https://doi.org/10.3390/nano11061400 SN - 2079-4991 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Naser, Eyad A1 - Kadow, Stephanie A1 - Schumacher, Fabian A1 - Mohamed, Zainelabdeen H. A1 - Kappe, Christian A1 - Hessler, Gabriele A1 - Pollmeier, Barbara A1 - Kleuser, Burkhard A1 - Arenz, Christoph A1 - Becker, Katrin Anne A1 - Gulbins, Erich A1 - Carpinteiro, Alexander T1 - Characterization of the small molecule ARC39 BT - a direct and specific inhibitor of acid sphingomyelinase in vitro[S] JF - Journal of Lipid Research N2 - Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory ASM in vitro. Results from investigating sphingomyelin phosphodiesterase 1 (SMPD1/Smpd1) mRNA and ASM protein levels suggested that ARC39 directly inhibits ASM's catalytic activity in cultured cells, a mechanism that differs from that of functional inhibitors of ASM. We further provide evidence that ARC39 dose- and time-dependently inhibits lysosomal ASM in intact cells, and we show that ARC39 also reduces platelet- and ASM-promoted adhesion of tumor cells. The observed toxicity of ARC39 is low at concentrations relevant for ASM inhibition in vitro, and it does not strongly alter the lysosomal compartment or induce phospholipidosis in vitro. When applied intraperitoneally in vivo, even subtoxic high doses administered short-term induced sphingomyelin accumulation only locally in the peritoneal lavage without significant accumulation in plasma, liver, spleen, or brain. These findings require further investigation with other possible chemical modifications. In conclusion, our results indicate that ARC39 potently and selectively inhibits ASM in vitro and highlight the need for developing compounds that can reach tissue concentrations sufficient for ASM inhibition in vivo. KW - sphingolipids KW - sphingomyelin KW - cerami-des KW - lipid metabolism KW - enzymology KW - lysosome KW - lysosomal hydrolases KW - acid ceramidase KW - bisphosphonates KW - functional inhibitors of acid sphin-gomyelinase KW - 1-aminodecylidene bis-phosphonic acid Y1 - 2021 U6 - https://doi.org/10.1194/jlr.RA120000682 SN - 1539-7262 SN - 0022-2275 VL - 61 IS - 6 SP - 896 EP - 910 PB - American Society for Biochemistry and Molecular Biology CY - Bethesda ER - TY - JOUR A1 - Marimon Tarter, Mireia A1 - Hofmann, Andrea A1 - Veríssimo, Joao Marques A1 - Männel, Claudia A1 - Friederici, Angela Dorkas A1 - Höhle, Barbara A1 - Wartenburger, Isabell T1 - Children’s Learning of Non-adjacent Dependencies Using a Web-Based Computer Game Setting JF - Frontiers in Psychology N2 - Infants show impressive speech decoding abilities and detect acoustic regularities that highlight the syntactic relations of a language, often coded via non-adjacent dependencies (NADs, e.g., is singing). It has been claimed that infants learn NADs implicitly and associatively through passive listening and that there is a shift from effortless associative learning to a more controlled learning of NADs after the age of 2 years, potentially driven by the maturation of the prefrontal cortex. To investigate if older children are able to learn NADs, Lammertink et al. (2019) recently developed a word-monitoring serial reaction time (SRT) task and could show that 6–11-year-old children learned the NADs, as their reaction times (RTs) increased then they were presented with violated NADs. In the current study we adapted their experimental paradigm and tested NAD learning in a younger group of 52 children between the age of 4–8 years in a remote, web-based, game-like setting (whack-a-mole). Children were exposed to Italian phrases containing NADs and had to monitor the occurrence of a target syllable, which was the second element of the NAD. After exposure, children did a “Stem Completion” task in which they were presented with the first element of the NAD and had to choose the second element of the NAD to complete the stimuli. Our findings show that, despite large variability in the data, children aged 4–8 years are sensitive to NADs; they show the expected differences in r RTs in the SRT task and could transfer the NAD-rule in the Stem Completion task. We discuss these results with respect to the development of NAD dependency learning in childhood and the practical impact and limitations of collecting these data in a web-based setting. KW - non-adjacent dependencies KW - rule learning KW - web-based KW - implicit learning KW - serial reaction time (SRT) task KW - SRT Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.734877 SN - 1664-1078 VL - 12 SP - 1 EP - 15 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Pikovskij, Arkadij T1 - Chimeras on a social-type network JF - Mathematical modelling of natural phenomena : MMNP N2 - We consider a social-type network of coupled phase oscillators. Such a network consists of an active core of mutually interacting elements, and of a flock of passive units, which follow the driving from the active elements, but otherwise are not interacting. We consider a ring geometry with a long-range coupling, where active oscillators form a fluctuating chimera pattern. We show that the passive elements are strongly correlated. This is explained by negative transversal Lyapunov exponents. KW - Network KW - Chimera KW - correlations KW - Lyapunov exponent Y1 - 2021 U6 - https://doi.org/10.1051/mmnp/2021012 SN - 0973-5348 SN - 1760-6101 VL - 16 PB - EDP Sciences CY - Les Ulis ER - TY - RPRT A1 - Mena, Wogene Berhanu T1 - Civilizational hexagon as a pathway to conflict management BT - examining its application in Sub-Saharan Africa in the post-cold war era T2 - State, Law, and Politics - Research and Discussion Papers T2 - Staat, Recht und Politik – Forschungs- und Diskussionspapiere N2 - This paper examines the attempts of implement-ing components of the concept called Civiliza-tional Hexagon as a pathway to civilizing conflict in the Sub-Saharan Africa in the post-Cold War period. Despite significant decline in the violent conflict and substantial progress socio-economic aspects in the period, most states in the region have been facing challenges in their way to civilize conflict related to absence of inclusive political system, weak state unable to monopolize the use of violence in its territory, and social injustice. On the other hand, states like Botswana and Mauritius managed to civilize conflict through significant improvement in democratic consolidation. Besides their relative success in implementing six elements, these states enabled to integrate traditional institutions with modern state apparatus that helped them to fill the gap created as result of exogenous state formation process and the resulting unfinished nation-building project. Additionally, traditional institutions contributed to managing diversity. N2 - Dieses Papier untersucht die Versuche, Komponenten des Konzepts „zivilisatorisches Hexagon“ als einen Weg zur Zivilisierung von Konlikten in Afrika südlich der Sahara nach 1990 umzusetzen. Trotz eines signifikanten Rückgangs der gewaltsamen Konflikte und erheblicher Fortschritte in sozio-ökonomischen Aspekten stehen die meisten Staaten in der Region vor Herausforderungen, die mit dem Fehlen eines inklusiven politischen Systems, einem schwachen Staat, der nicht in der Lage ist, das Gewaltmonopol in seinem Territorium auszuüben, und sozialer Ungerechtigkeit zusammenhängen. Gleichwohl sind Staaten wie Botswana und Mauritius in der Lage, Konflikte durch signifikante Verbesserung der demokratischen Konsolidierung zu zivilisieren. Neben ihrem relativen Erfolg bei der Umsetzung der sechs Elemente haben diese Staaten es geschafft, traditionelle Institutionen in den modernen Staatsapparat zu integrieren, was ihnen half, die Lücke zu füllen, die durch den exogenen Staatsbildungsprozess und das daraus resultierende unvollendete Projekt der Nationenbildung entstanden war. Zusätzlich halfen die traditionellen Institutionen dabei, Vielfalt zu sichern. T3 - Staat, Recht und Politik – Forschungs- und Diskussionspapiere = State, Law, and Politics - Research and Discussion Papers - 11 KW - conflict management KW - Sub-Saharan Africa Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516695 SN - 2509-6974 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Sperlich, Eric A1 - Köckerling, Martin T1 - Cluster salts [Nb6Cl12(HIm)(6)]A(n) (with HIm=1H-imidazole and A=Mineral Acid Anion, n=1 or 2) made in and with Bronsted-basic ionic liquids and liquid mixtures JF - ChemistryOpen N2 - Four new hexanuclear niobium cluster compounds of the general formula [Nb6Cl12(HIm)(6)](A)(n) . x(solvent molecule) (HIm=1H-imidazole, A=mineral acid anion, Cl- (n=2) (1), (SO4)(2-) (n=1) (2), (CrO4)(2-) (n=1) (3), and (HAsO4)(2-) (n=1) (4)) were prepared. Their synthesis can be done in basic ionic liquids, which form on the addition of a mineral acid, which also delivers the counter anion for the final cluster compound, to an excess of the 1H-imidazole. Some addition of an auxiliary solvent, like methanol, improves the speed of crystallisation. The cluster unit comprises a hexanuclear Nb-6 unit of octahedral shape with the edges bridged by Cl atoms and the exo sites being occupied by N-bonded 1H-imidazole ligands. The cluster cation carries sixteen cluster-based electrons. Between the NH groups of the ligands of the cluster unit, the anions and the co-crystallised water (1), or 1H-imidazole and methanol molecules (2, 3, and 4) a network of hydrogen bonds exists. KW - cluster KW - ionic liquid KW - structure elucidation KW - heterocyclic ligand KW - Niobium Y1 - 2021 U6 - https://doi.org/10.1002/open.202000266 SN - 2191-1363 VL - 10 IS - 2 SP - 248 EP - 254 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Diluiso, Francesca A1 - Walk, Paula A1 - Manych, Niccolo A1 - Cerutti, Nicola A1 - Chipiga, Vladislav A1 - Workman, Annabelle A1 - Ayas, Ceren A1 - Cui, Ryna Yiyun A1 - Cui, Diyang A1 - Song, Kaihui A1 - Banisch, Lucy A. A1 - Moretti, Nikolaj A1 - Callaghan, Max W. A1 - Clarke, Leon A1 - Creutzig, Felix A1 - Hilaire, Jerome A1 - Jotzo, Frank A1 - Kalkuhl, Matthias A1 - Lamb, William F. A1 - Löschel, Andreas A1 - Müller-Hansen, Finn A1 - Nemet, Gregory F. A1 - Oei, Pao-Yu A1 - Sovacool, Benjamin K. A1 - Steckel, Jan Christoph A1 - Thomas, Sebastian A1 - Wiseman, John A1 - Minx, Jan C. T1 - Coal transitions - part 1 BT - a systematic map and review of case study learnings from regional, national, and local coal phase-out experiences JF - Environmental research letters N2 - A rapid coal phase-out is needed to meet the goals of the Paris Agreement, but is hindered by serious challenges ranging from vested interests to the risks of social disruption. To understand how to organize a global coal phase-out, it is crucial to go beyond cost-effective climate mitigation scenarios and learn from the experience of previous coal transitions. Despite the relevance of the topic, evidence remains fragmented throughout different research fields, and not easily accessible. To address this gap, this paper provides a systematic map and comprehensive review of the literature on historical coal transitions. We use computer-assisted systematic mapping and review methods to chart and evaluate the available evidence on historical declines in coal production and consumption. We extracted a dataset of 278 case studies from 194 publications, covering coal transitions in 44 countries and ranging from the end of the 19th century until 2021. We find a relatively recent and rapidly expanding body of literature reflecting the growing importance of an early coal phase-out in scientific and political debates. Previous evidence has primarily focused on the United Kingdom, the United States, and Germany, while other countries that experienced large coal declines, like those in Eastern Europe, are strongly underrepresented. An increasing number of studies, mostly published in the last 5 years, has been focusing on China. Most of the countries successfully reducing coal dependency have undergone both demand-side and supply-side transitions. This supports the use of policy approaches targeting both demand and supply to achieve a complete coal phase-out. From a political economy perspective, our dataset highlights that most transitions are driven by rising production costs for coal, falling prices for alternative energies, or local environmental concerns, especially regarding air pollution. The main challenges for coal-dependent regions are structural change transformations, in particular for industry and labor. Rising unemployment is the most largely documented outcome in the sample. Policymakers at multiple levels are instrumental in facilitating coal transitions. They rely mainly on regulatory instruments to foster the transitions and compensation schemes or investment plans to deal with their transformative processes. Even though many models suggest that coal phase-outs are among the low-hanging fruits on the way to climate neutrality and meeting the international climate goals, our case studies analysis highlights the intricate political economy at work that needs to be addressed through well-designed and just policies. KW - climate change mitigation KW - coal transitions KW - evidence synthesis KW - political economy KW - systematic map Y1 - 2021 U6 - https://doi.org/10.1088/1748-9326/ac1b58 SN - 1748-9326 VL - 16 IS - 11 PB - Institute of Physics Publishing (IOP) CY - Bristol ER - TY - JOUR A1 - Topali, Paraskevi A1 - Chounta, Irene-Angelica A1 - Ortega-Arranz, Alejandro A1 - Villagrá-Sobrino, Sara L. A1 - Martínez-Monés, Alejandra T1 - CoFeeMOOC-v.2 BT - Designing Contingent Feedback for Massive Open Online Courses JF - EMOOCs 2021 N2 - Providing adequate support to MOOC participants is often a challenging task due to massiveness of the learners’ population and the asynchronous communication among peers and MOOC practitioners. This workshop aims at discussing common learners’ problems reported in the literature and reflect on designing adequate feedback interventions with the use of learning data. Our aim is three-fold: a) to pinpoint MOOC aspects that impact the planning of feedback, b) to explore the use of learning data in designing feedback strategies, and c) to propose design guidelines for developing and delivering scaffolding interventions for personalized feedback in MOOCs. To do so, we will carry out hands-on activities that aim to involve participants in interpreting learning data and using them to design adaptive feedback. This workshop appeals to researchers, practitioners and MOOC stakeholders who aim to providing contextualized scaffolding. We envision that this workshop will provide insights for bridging the gap between pedagogical theory and practice when it comes to feedback interventions in MOOCs. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-517241 SN - 978-3-86956-512-5 VL - 2021 SP - 209 EP - 217 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Tönjes, Ralf A1 - Fiore, Carlos E. A1 - Pereira da Silva, Tiago T1 - Coherence resonance in influencer networks JF - Nature Communications N2 - Complex networks are abundant in nature and many share an important structural property: they contain a few nodes that are abnormally highly connected (hubs). Some of these hubs are called influencers because they couple strongly to the network and play fundamental dynamical and structural roles. Strikingly, despite the abundance of networks with influencers, little is known about their response to stochastic forcing. Here, for oscillatory dynamics on influencer networks, we show that subjecting influencers to an optimal intensity of noise can result in enhanced network synchronization. This new network dynamical effect, which we call coherence resonance in influencer networks, emerges from a synergy between network structure and stochasticity and is highly nonlinear, vanishing when the noise is too weak or too strong. Our results reveal that the influencer backbone can sharply increase the dynamical response in complex systems of coupled oscillators. Influencer networks include a small set of highly-connected nodes and can reach synchrony only via strong node interaction. Tonjes et al. show that introducing an optimal amount of noise enhances synchronization of such networks, which may be relevant for neuroscience or opinion dynamics applications. Y1 - 2021 U6 - https://doi.org/10.1038/s41467-020-20441-4 SN - 2041-1723 VL - 12 IS - 1 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Soergel, Bjoern A1 - Kriegler, Elmar A1 - Bodirsky, Benjamin Leon A1 - Bauer, Nico A1 - Leimbach, Marian A1 - Popp, Alexander T1 - Combining ambitious climate policies with efforts to eradicate poverty JF - Nature Communications N2 - Climate change threatens to undermine efforts to eradicate extreme poverty. However, climate policies could impose a financial burden on the global poor through increased energy and food prices. Here, we project poverty rates until 2050 and assess how they are influenced by mitigation policies consistent with the 1.5 degrees C target. A continuation of historical trends will leave 350 million people globally in extreme poverty by 2030. Without progressive redistribution, climate policies would push an additional 50 million people into poverty. However, redistributing the national carbon pricing revenues domestically as an equal-per-capita climate dividend compensates this policy side effect, even leading to a small net reduction of the global poverty headcount (-6 million). An additional international climate finance scheme enables a substantial poverty reduction globally and also in Sub-Saharan Africa. Combining national redistribution with international climate finance thus provides an important entry point to climate policy in developing countries. Ambitious climate policies can negatively impact the global poor by affecting income, food and energy prices. Here, the authors quantify this effect, and show that it can be compensated by national redistribution of the carbon pricing revenues in combination with international climate finance. Y1 - 2021 U6 - https://doi.org/10.1038/s41467-021-22315-9 SN - 2041-1723 VL - 12 PB - Nature Publishing Group CY - London ER - TY - JOUR A1 - Kühne, Franziska A1 - Fauth, Henriette A1 - Destina Sevde, Ay-Bryson A1 - Visser, Leonie N.C. A1 - Weck, Florian T1 - Communicating the diagnosis of cancer or depression: Results of a randomized controlled online study using video vignettes JF - Cancer Medicine N2 - Background Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study. Methods Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied. Results Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61–1.06). Conclusions The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer. KW - consultation KW - mental health KW - oncology KW - psycho-oncology KW - skills Y1 - 2021 U6 - https://doi.org/10.1002/cam4.4396 SN - 2045-7634 VL - 10 SP - 9012 EP - 9021 PB - Wiley CY - Hoboken, New Jersey, USA ET - 24 ER - TY - JOUR A1 - Hohaus, Vera A1 - Zimmermann, Malte T1 - Comparisons of equality with German so ... wie, and the relationship between degrees and properties JF - Journal of semantics N2 - We present a compositionally transparent, unified semantic analysis of two kinds of so ... wie-equative constructions in German, namely degree equatives and property equatives in the domain of individuals or events. Unlike in English and many other European languages (Haspelmath & Buchholz 1998, Rett 2013), both equative types in German feature the parameter marker so, suggesting a unified analysis. We show that the parallel formal expression of German degree and property equatives is accompanied by a parallel syntactic distribution (in predicative, attributive, and adverbial position), and by identical semantic properties: Both equative types allow for scope ambiguities, show negative island effects out of context, and license the negative polarity item uberhaupt 'at all' in the complement clause. As the same properties are also shared by German comparatives, we adopt the influential quantificational analysis of comparatives in von Stechow (1984ab), Heim (1985, 2001, 2007), and Beck (2011), and treat both German equative types in a uniform manner as expressing universal quantification over sets of degrees or over sets of properties (of individuals or events). Conceptually, the uniform marking of degree-related and property-related meanings is expected given that the abstract semantic category degree (type ) can be reconstructed in terms of equivalence classes, i.e., ontologically simpler sets of individuals (type ) or events (type ). These are found in any language, showing that whether or not a language makes explicit reference to degrees (by means of gradable adjectives, degree question words, degree-only equatives) does not follow on general conceptual or semantic grounds, but is determined by the grammar of that language. Y1 - 2021 U6 - https://doi.org/10.1093/jos/ffaa011 SN - 0167-5133 SN - 1477-4593 VL - 38 IS - 1 SP - 95 EP - 143 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Wiesner, Karoline A1 - Ladyman, James T1 - Complex systems are always correlated but rarely information processing JF - Journal of physics. Complexity N2 - 'Complex systems are information processors' is a statement that is frequently made. Here we argue for the distinction between information processing-in the sense of encoding and transmitting a symbolic representation-and the formation of correlations (pattern formation/self-organisation). The study of both uses tools from information theory, but the purpose is very different in each case: explaining the mechanisms and understanding the purpose or function in the first case, versus data analysis and correlation extraction in the latter. We give examples of both and discuss some open questions. The distinction helps focus research efforts on the relevant questions in each case. KW - correlations KW - information theory KW - complex systems KW - information KW - processing KW - self-organisation Y1 - 2021 U6 - https://doi.org/10.1088/2632-072X/ac371c SN - 2632-072X VL - 2 IS - 4 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Perscheid, Cindy T1 - Comprior BT - Facilitating the implementation and automated benchmarking of prior knowledge-based feature selection approaches on gene expression data sets JF - BMC Bioinformatics N2 - Background Reproducible benchmarking is important for assessing the effectiveness of novel feature selection approaches applied on gene expression data, especially for prior knowledge approaches that incorporate biological information from online knowledge bases. However, no full-fledged benchmarking system exists that is extensible, provides built-in feature selection approaches, and a comprehensive result assessment encompassing classification performance, robustness, and biological relevance. Moreover, the particular needs of prior knowledge feature selection approaches, i.e. uniform access to knowledge bases, are not addressed. As a consequence, prior knowledge approaches are not evaluated amongst each other, leaving open questions regarding their effectiveness. Results We present the Comprior benchmark tool, which facilitates the rapid development and effortless benchmarking of feature selection approaches, with a special focus on prior knowledge approaches. Comprior is extensible by custom approaches, offers built-in standard feature selection approaches, enables uniform access to multiple knowledge bases, and provides a customizable evaluation infrastructure to compare multiple feature selection approaches regarding their classification performance, robustness, runtime, and biological relevance. Conclusion Comprior allows reproducible benchmarking especially of prior knowledge approaches, which facilitates their applicability and for the first time enables a comprehensive assessment of their effectiveness KW - Feature selection KW - Prior knowledge KW - Gene expression KW - Reproducible benchmarking Y1 - 2021 U6 - https://doi.org/10.1186/s12859-021-04308-z SN - 1471-2105 VL - 22 SP - 1 EP - 15 PB - Springer Nature CY - London ER - TY - JOUR A1 - Eikerling, Maren A1 - Vona, Francesco A1 - Garzotto, Franca A1 - Lorusso, Maria Luisa T1 - Computergestützte, bilinguale Screenings BT - Risikoidentifikation von LRS und SES bei zweisprachigen Kindern mit der modifizierbaren Web-App MuLiMi JF - Spektrum Patholinguistik Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510426 SN - 978-3-86956-507-1 SN - 1866-9085 SN - 1866-9433 IS - 14 SP - 139 EP - 147 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Sandau, Ingo A1 - Chaabene, Helmi A1 - Granacher, Urs T1 - Concurrent validity of barbell force measured from video-based barbell kinematics during the snatch in male elite weightlifters JF - PLOS ONE / Public Library of Science N2 - This study examined the concurrent validity of an inverse dynamic (force computed from barbell acceleration [reference method]) and a work-energy (force computed from work at the barbell [alternative method]) approach to measure the mean vertical barbell force during the snatch using kinematic data from video analysis. For this purpose, the acceleration phase of the snatch was analyzed in thirty male medal winners of the 2018 weightlifting World Championships (age: 25.2±3.1 years; body mass: 88.9±28.6 kg). Vertical barbell kinematics were measured using a custom-made 2D real-time video analysis software. Agreement between the two computational approaches was assessed using Bland-Altman analysis, Deming regression, and Pearson product-moment correlation. Further, principal component analysis in conjunction with multiple linear regression was used to assess whether individual differences related to the two approaches are due to the waveforms of the acceleration time-series data. Results indicated no mean difference (p > 0.05; d = −0.04) and an extremely large correlation (r = 0.99) between the two approaches. Despite the high agreement, the total error of individual differences was 8.2% (163.0 N). The individual differences can be explained by a multiple linear regression model (R2adj = 0.86) on principal component scores from the principal component analysis of vertical barbell acceleration time-series waveforms. Findings from this study indicate that the individual errors of force measures can be associated with the inverse dynamic approach. This approach uses vertical barbell acceleration data from video analysis that is prone to error. Therefore, it is recommended to use the work-energy approach to compute mean vertical barbell force as this approach did not rely on vertical barbell acceleration. KW - Acceleration KW - Linear regression analysis KW - Velocity KW - Principal component analysis KW - Kinematics KW - Motion KW - Scanning electron microscopy KW - Computer Software Y1 - 2021 U6 - https://doi.org/10.1371/journal.pone.0254705 SN - 1932-6203 VL - 16 IS - 7 PB - PLOS CY - San Francisco ER - TY - JOUR A1 - Beirne, Elaine A1 - Nic Giolla Mhichíl, Mairéad A1 - Brown, Mark A1 - Mac Lochlainn, Conchúr T1 - Confidence Counts BT - Fostering Online Learning Self-Efficacy with a MOOC JF - EMOOCs 2021 N2 - The increasing reliance on online learning in higher education has been further expedited by the on-going Covid-19 pandemic. Students need to be supported as they adapt to this new learning environment. Research has established that learners with positive online learning self-efficacy beliefs are more likely to persevere and achieve their higher education goals when learning online. In this paper, we explore how MOOC design can contribute to the four sources of self-efficacy beliefs posited by Bandura [4]. Specifically, we will explore, drawing on learner reflections, whether design elements of the MOOC, The Digital Edge: Essentials for the Online Learner, provided participants with the necessary mastery experiences, vicarious experiences, verbal persuasion, and affective regulation opportunities, to evaluate and develop their online learning self-efficacy beliefs. Findings from a content analysis of discussion forum posts show that learners referenced three of the four information sources when reflecting on their experience of the MOOC. This paper illustrates the potential of MOOCs as a pedagogical tool for enhancing online learning self-efficacy among students. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-517220 SN - 978-3-86956-512-5 VL - 2021 SP - 201 EP - 208 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Gorin, Vladislav A. A1 - Scherz, Mark D. A1 - Korost, Dmitry V. A1 - Poyarkov, Nikolay A. T1 - Consequences of parallel miniaturisation in Microhylinae (Anura, Microhylidae), with the description of a new genus of diminutive South East Asian frogs JF - Zoosystematics and evolution : Mitteilungen aus dem Museum für Naturkunde in Berlin N2 - The genus Microhyla Tschudi, 1838 includes 52 species and is one of the most diverse genera of the family Microhylidae, being the most species-rich taxon of the Asian subfamily Microhylinae. The recent, rapid description of numerous new species of Microhyla with complex phylogenetic relationships has made the taxonomy of the group especially challenging. Several recent phylogenetic studies suggested paraphyly of Microhyla with respect to Glyphoglossus Gunther, 1869, and revealed three major phylogenetic lineages of mid-Eocene origin within this assemblage. However, comprehensive works assessing morphological variation among and within these lineages are absent. In the present study we investigate the generic taxonomy of Microhyla-Glyphoglossus assemblage based on a new phylogeny including 57 species, comparative morphological analysis of skeletons from cleared-and-stained specimens for 23 species, and detailed descriptions of generalized osteology based on volume-rendered micro-CT scans for five speciesal-together representing all major lineages within the group. The results confirm three highly divergent and well-supported clades that correspond with external and osteological morphological characteristics, as well as respective geographic distribution. Accordingly, acknowledging ancient divergence between these lineages and their significant morphological differentiation, we propose to consider these three lineages as distinct genera: Microhyla sensu stricto, Glyphoglossus, and a newly described genus, Nanohyla gen. nov. KW - Amphibians KW - integrative taxonomy KW - narrow-mouthed frogs KW - micro-computed tomography KW - Nanohyla gen. nov KW - osteology KW - sexual dimorphism KW - taxonomic revision Y1 - 2021 U6 - https://doi.org/10.3897/zse.97.57968 SN - 1860-0743 VL - 97 IS - 1 SP - 21 EP - 54 PB - Pensoft Publishers CY - Sofia ER - TY - JOUR A1 - Saura-Ziegelmeyer, Arnaud ED - Bièvre-Perrin, Fabien ED - Carlà-Uhink, Filippo ED - Rollinger, Christian ED - Walde, Christine T1 - Construire ses propres modèles : le cas des bandes sonores post-Gladiator JF - thersites 13: Antiquipop – Chefs d’œuvres revisités N2 - Ringing trumpets announcing the arrival of a Roman emperor, an oriental flowing and delicate harp reverberating inside the intimate palace of an Egyptian queen, a rude aulos singing in a bucolic Greek landscape: where are these familiar sound images coming from? Are these creations inspired by archaeological data or built after modern fantasy? The scarcity of ancient musical data necessitated, in fact, to reinvent the films’ soundscape taking place in the Ancient world. It is therefore a question of seeing on which models a peplum’s soundtrack is conceived and what it can reveal on our way of perceiving the ancient and contemporary world. Far from wanting to gauge the historicity of the sound backgrounds offered to the spectator of dark rooms, it is rather a question of seeing the imitation phenomena that can appear from the sound clichés created by the peplum itself and of also deducing from them thought patterns which, contextualized, influence these compositions. This article will focus on post-2000 productions. KW - music KW - peplum KW - antiquity KW - otherness KW - reception studies Y1 - 2021 U6 - https://doi.org/10.34679/thersites.vol13.150 SN - 2364-7612 VL - 2021 IS - 13 SP - 141 EP - 168 ER - TY - JOUR A1 - Fischer, Melanie A1 - Korup, Oliver A1 - Veh, Georg A1 - Walz, Ariane T1 - Controls of outbursts of moraine-dammed lakes in the greater Himalayan region JF - The Cryosphere N2 - Glacial lakes in the Hindu Kush–Karakoram–Himalayas–Nyainqentanglha (HKKHN) region have grown rapidly in number and area in past decades, and some dozens have drained in catastrophic glacial lake outburst floods (GLOFs). Estimating regional susceptibility of glacial lakes has largely relied on qualitative assessments by experts, thus motivating a more systematic and quantitative appraisal. Before the backdrop of current climate-change projections and the potential of elevation-dependent warming, an objective and regionally consistent assessment is urgently needed. We use an inventory of 3390 moraine-dammed lakes and their documented outburst history in the past four decades to test whether elevation, lake area and its rate of change, glacier-mass balance, and monsoonality are useful inputs to a probabilistic classification model. We implement these candidate predictors in four Bayesian multi-level logistic regression models to estimate the posterior susceptibility to GLOFs. We find that mostly larger lakes have been more prone to GLOFs in the past four decades regardless of the elevation band in which they occurred. We also find that including the regional average glacier-mass balance improves the model classification. In contrast, changes in lake area and monsoonality play ambiguous roles. Our study provides first quantitative evidence that GLOF susceptibility in the HKKHN scales with lake area, though less so with its dynamics. Our probabilistic prognoses offer improvement compared to a random classification based on average GLOF frequency. Yet they also reveal some major uncertainties that have remained largely unquantified previously and that challenge the applicability of single models. Ensembles of multiple models could be a viable alternative for more accurately classifying the susceptibility of moraine-dammed lakes to GLOFs. Y1 - 2020 U6 - https://doi.org/10.5194/tc-15-4145-2021 SN - 1994-0416 VL - 15 PB - Copernicus Publications CY - Göttingen ER - TY - JOUR A1 - Wendt, Martin A1 - Senftleben, Nele A1 - Gros, Patrick A1 - Schmitt, Thomas T1 - Coping with environmental extremes BT - population ecology and behavioural adaptation of Erebia pronoe, an Alpine butterfly species JF - Insects : open access journal N2 - Simple Summary:& nbsp;High alpine meadows are home to numerous endemic butterfly species. A combination of climate change and changes in agricultural practices has led to a severe decline in many species. A seemingly unaffected representative of this habitat is Erebia pronoe. We studied the behaviour, resource use and population structure of this species to explain its resilience and estimate its future survival potential. This species shows pronounced protandry in combination with serial eclosion. Males were significantly more active and mobile and were also caught significantly more often than females, resulting in a pronounced shift in sex ratio in the predicted population structure. The adults use a wide range of nectar plants and establish homeranges in areas of high habitat quality. Thus, Erebia pronoe adults use a wide array of resources combined with a slight specialisation to avoid niche overlap with closely related species. The resulting ecological flexibility seems to be an adaptation to unpredictable environmental conditions, which should be the result of a long-lasting adaptation process. Moreover, the combination of opportunism and modest specialisation should also be a good basis for coping with future changes caused by climate and land-use change.




A mark-recapture study of the nominotypical Erebia pronoe in the Alps was conducted to survey its ecological demands and characteristics. Population structure analysis revealed a combination of protandry (one-week earlier eclosion of males) and serial eclosion. Significant differences between both sexes were found in population density (males: 580/ha & PLUSMN; 37 SE; females: 241/ha & PLUSMN; 66 SE), sex-ratio (2.4) and behaviour (57.7 vs. 11.9% flying). Both sexes used a wide range of nectar plants (Asteraceae, 77.3%; Dipsacaceae, 12.3%; Gentianaceae, 9.7%). The use of nectar plants shows a non-specific spectrum, which, however, completely avoids overlap with the locally co-occurring species Erebia nivalis. Movement patterns show the establishment of homeranges, which significantly limits the migration potential. Due to its broad ecological niche, E. pronoe will probably be able to react plastically to the consequences of climate change. The formation of high population densities, the unconcerned endangerment status, the unspecific resource spectrum and the sedentary character of the species make E. pronoe a potential indicator of the quality and general resource occurrence of alpine rupicolous grasslands. KW - mark-release-recapture KW - movement patterns KW - opportunistic behaviour KW - partial protandry KW - population demography Y1 - 2021 U6 - https://doi.org/10.3390/insects12100896 SN - 2075-4450 VL - 12 IS - 10 PB - MDPI CY - Basel ER - TY - JOUR A1 - Lever, Fabiano A1 - Mayer, Dennis A1 - Metje, Jan A1 - Alisauskas, Skirmantas A1 - Calegari, Francesca A1 - Düsterer, Stefan A1 - Feifel, Raimund A1 - Niebuhr, Mario A1 - Manschwetus, Bastian A1 - Kuhlmann, Marion A1 - Mazza, Tommaso A1 - Robinson, Matthew Scott A1 - Squibb, Richard J. A1 - Trabattoni, Andrea A1 - Wallner, Måns A1 - Wolf, Thomas J. A. A1 - Gühr, Markus T1 - Core-level spectroscopy of 2-thiouracil at the sulfur L1 and L2,3 edges utilizing a SASE free-electron-laser JF - Molecules N2 - In this paper, we report X-ray absorption and core-level electron spectra of the nucleobase derivative 2-thiouracil at the sulfur L1- and L2,3-edges. We used soft X-rays from the free-electron laser FLASH2 for the excitation of isolated molecules and dispersed the outgoing electrons with a magnetic bottle spectrometer. We identified photoelectrons from the 2p core orbital, accompanied by an electron correlation satellite, as well as resonant and non-resonant Coster–Kronig and Auger–Meitner emission at the L1- and L2,3-edges, respectively. We used the electron yield to construct X-ray absorption spectra at the two edges. The experimental data obtained are put in the context of the literature currently available on sulfur core-level and 2-thiouracil spectroscopy. KW - X-ray KW - photoelectron KW - sulfur KW - thiouracil KW - nucleobases KW - Coster–Kronig KW - Auger–Meitner KW - NEXAFS KW - FLASH Y1 - 2021 SN - 1420-3049 VL - 26 IS - 21 PB - MDPI CY - Basel ER - TY - GEN A1 - Wachs, Sebastian A1 - Wright, Michelle F. A1 - Sittichai, Ruthaychonnee T1 - Correction: Associations between witnessing and perpetrating online hate in eight countries: The Buffering Effects of Problem-Focused Coping. T2 - International Journal Environmental Research and Public Health N2 - Kein Abstract vorhanden Y1 - 2021 U6 - https://doi.org/10.3390/ijerph18052609 SN - 1661-7827 SN - 1660-4601 VL - 18 IS - 3992 SP - 1 EP - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Felser, Claudia A1 - Jessen, Anna T1 - Correlative coordination and variable subject-verb agreement in German JF - Languages : open access journal N2 - Coordinated subjects often show variable number agreement with the finite verb, but linguistic approaches to this phenomenon have rarely been informed by systematically collected data. We report the results from three experiments investigating German speakers' agreement preferences with complex subjects joined by the correlative conjunctions sowohl horizontal ellipsis als auch ('both horizontal ellipsis and'), weder horizontal ellipsis noch ('neither horizontal ellipsis nor') or entweder horizontal ellipsis oder ('either horizontal ellipsis or'). We examine to what extent conjunction type and a conjunct's relative proximity to the verb affect the acceptability and processibility of singular vs. plural agreement. Experiment 1 was an untimed acceptability rating task, Experiment 2 a timed sentence completion task, and Experiment 3 was a self-paced reading task. Taken together, our results show that number agreement with correlative coordination in German is primarily determined by a default constraint triggering plural agreement, which interacts with linear order and semantic factors. Semantic differences between conjunctions only affected speakers' agreement preferences in the absence of processing pressure but not their initial agreement computation. The combined results from our offline and online experimental measures of German speakers' agreement preferences suggest that the constraints under investigation do not only differ in their relative weighting but also in their relative timing during agreement computation. KW - correlative coordination KW - subject– verb agreement KW - German Y1 - 2021 U6 - https://doi.org/10.3390/languages6020067 SN - 2226-471X VL - 6 IS - 2 PB - MDPI CY - Basel ER -