TY  - GEN
A1  - Reichetzeder, Christoph
A1  - Hocher, Berthold
T1  - DPP4 inhibition prevents AKI
T2  - Oncotarget
KW  - acute kidney injury
KW  - DPP-4 inhibitors
KW  - ischemia reperfusion injury
KW  - gliptins
KW  - Dipeptidyl peptidase IV
Y1  - 2017
U6  - https://doi.org/10.18632/oncotarget.20212
SN  - 1949-2553
VL  - 8
SP  - 64655
EP  - 64656
PB  - Impact Journals LLC
CY  - Orchard Park
ER  - 
TY  - JOUR
A1  - Islam, Khan M. S.
A1  - Khalil, Mahmoud Abd Elhamid
A1  - Maenner, Klaus
A1  - Raila, Jens
A1  - Rawel, Harshadrai Manilal
A1  - Zentek, Jürgen
A1  - Schweigert, Florian J.
T1  - Lutein Specific Relationships among Some Spectrophotometric and Colorimetric Parameters of Chicken Egg Yolk
JF  - The journal of poultry science
N2  - Lutein is an essential dietary carotenoid with health benefits and is inter alia responsible for the colouration of egg yolk. The relationship between lutein accumulation and egg yolk colouration was therefore studied in more detail. After feeding a low-luteine diet for 21 days, 14 birds (Lohmann brown hens aged 20 weeks) were fed a diet containing marigold (80 mg lutein/kg feed) and 14 other birds were fed a diet containing oleoresin (45 mg lutein/kg feed) for 21 days; for both groups of birds, this feeding period was followed by withdrawal for 21 days. The Roche Yolk Colour Fan (RYCF) score (0 to 15, where higher values denote greater colour intensity; R-2=0.87; P<0.01) and redness (R-2=0.89; P<0.01) increased with increasing lutein content of egg yolk. Total carotenoid content had a poor relationship with lightness (R-2=0.13; P>0.05) and yellowness (R-2=0.12; P>0.05) of the yolk. It may be concluded that increased lutein is potentially responsible for an increased RYCF score and redness (a*), but decreased yellowness (b*) and lightness (L*), of egg yolk.
KW  - carotenoid
KW  - HPLC
KW  - iCheck
KW  - lutein
KW  - spectrophotometry
KW  - yolk
Y1  - 2017
U6  - https://doi.org/10.2141/jpsa.0160065
SN  - 1346-7395
VL  - 54
SP  - 271
EP  - 277
PB  - Japan Poultry Science Association
CY  - Tsukuba
ER  - 
TY  - JOUR
A1  - Bernacchioni, Caterina
A1  - Ghini, Veronica
A1  - Cencetti, Francesca
A1  - Japtok, Lukasz
A1  - Donati, Chiara
A1  - Bruni, Paola
A1  - Turano, Paola
T1  - NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells
JF  - Molecular oncology / Federation of European Biochemical Societies
N2  - Strong experimental evidence in animal and cellular models supports a pivotal role of sphingosine kinase-1 (SK1) in oncogenesis. In many human cancers, SK1 levels are upregulated and these increases are linked to poor prognosis in patients. Here, by employing untargeted NMR- based metabolomic profiling combined with functional validations, we report the crucial role of SK1 in the metabolic shift known as the Warburg effect in A2780 ovarian cancer cells. Indeed, expression of SK1 induced a high glycolytic rate, characterized by increased levels of lactate along with increased expression of the proton/monocarboxylate symporter MCT1, and decreased oxidative metabolism, associated with the accumulation of intermediates of the tricarboxylic acid cycle and reduction in CO2 production. Additionally, SK1-expressing cells displayed a significant increase in glucose uptake paralleled by GLUT3 transporter upregulation. The role of SK1 is not limited to the induction of aerobic glycolysis, affecting metabolic pathways that appear to support the biosynthesis of macromolecules. These findings highlight the role of SK1 signaling axis in cancer metabolic reprogramming, pointing out innovative strategies for cancer therapies.
KW  - NMR-based metabolomics
KW  - ovarian cancer
KW  - sphingosine kinase-1
KW  - Warburg effect
Y1  - 2017
U6  - https://doi.org/10.1002/1878-0261.12048
SN  - 1878-0261
VL  - 11
SP  - 517
EP  - 533
PB  - Wiley
CY  - Hoboken
ER  -