TY - JOUR A1 - Mota, Simon A1 - Leckelt, Marius A1 - Geukes, Katharina A1 - Nestler, Steffen A1 - Humberg, Sarah A1 - Schröder-Abe, Michela A1 - Schmukle, Stefan C. A1 - Back, Mitja D. T1 - A comprehensive examination of narcissists’ self-perceived and actual socioemotional cognition ability JF - Collabra: Psychology N2 - Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed. KW - narcissism KW - socioemotional cognition KW - self-perceived ability KW - actual ability KW - empathy KW - emotional intelligence KW - self-enhancement Y1 - 2018 U6 - https://doi.org/10.1525/collabra.174 SN - 2474-7394 VL - 5 IS - 1 PB - University of California Press CY - Oakland ER - TY - JOUR A1 - Risbey, James S. A1 - Lewandowsky, Stephan A1 - Cowtan, Kevin A1 - Oreskes, Naomi A1 - Rahmstorf, Stefan A1 - Jokimäki, Ari A1 - Foster, Grant T1 - A fluctuation in surface temperature in historical context BT - reassessment and retrospective on the evidence JF - Environmental research letters N2 - This work reviews the literature on an alleged global warming 'pause' in global mean surface temperature (GMST) to determine how it has been defined, what time intervals are used to characterise it, what data are used to measure it, and what methods used to assess it. We test for 'pauses', both in the normally understood meaning of the term to mean no warming trend, as well as for a 'pause' defined as a substantially slower trend in GMST. The tests are carried out with the historical versions of GMST that existed for each pause-interval tested, and with current versions of each of the GMST datasets. The tests are conducted following the common (but questionable) practice of breaking the linear fit at the start of the trend interval ('broken' trends), and also with trends that are continuous with the data bordering the trend interval. We also compare results when appropriate allowance is made for the selection bias problem. The results show that there is little or no statistical evidence for a lack of trend or slower trend in GMST using either the historical data or the current data. The perception that there was a 'pause' in GMST was bolstered by earlier biases in the data in combination with incomplete statistical testing. KW - climate variability KW - climate trends KW - temperature fluctuation KW - pause hiatus Y1 - 2018 U6 - https://doi.org/10.1088/1748-9326/aaf342 SN - 1748-9326 VL - 13 IS - 12 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Basler, Georg A1 - Fernie, Alisdair R. A1 - Nikoloski, Zoran T1 - Advances in metabolic flux analysis toward genome-scale profiling of higher organisms JF - Bioscience reports : communications and reviews in molecular and cellular biology N2 - Methodological and technological advances have recently paved the way for metabolic flux profiling in higher organisms, like plants. However, in comparison with omics technologies, flux profiling has yet to provide comprehensive differential flux maps at a genome-scale and in different cell types, tissues, and organs. Here we highlight the recent advances in technologies to gather metabolic labeling patterns and flux profiling approaches. We provide an opinion of how recent local flux profiling approaches can be used in conjunction with the constraint-based modeling framework to arrive at genome-scale flux maps. In addition, we point at approaches which use metabolomics data without introduction of label to predict either non-steady state fluxes in a time-series experiment or flux changes in different experimental scenarios. The combination of these developments allows an experimentally feasible approach for flux-based large-scale systems biology studies. Y1 - 2018 U6 - https://doi.org/10.1042/BSR20170224 SN - 0144-8463 SN - 1573-4935 VL - 38 PB - Portland Press (London) CY - London ER - TY - JOUR A1 - Randall, Matthew J. A1 - Jüngel, Astrid A1 - Rimann, Markus A1 - Wuertz-Kozak, Karin T1 - Advances in the biofabrication of 3D Skin in vitro BT - healthy and pathological models JF - Frontiers in Bioengineeringand Biotechnology N2 - The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation. Y1 - 2018 U6 - https://doi.org/10.3389/fbioe.2018.00154 SN - 2296-4185 VL - 6 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hargis, Hailey A1 - Gotsch, Sybil G. A1 - Porada, Philipp A1 - Moore, Georgianne W. A1 - Ferguson, Briana A1 - Van Stan, John T. T1 - Arboreal epiphytes in the soil-atmosphere interface BT - how often are the biggest "buckets" in the canopy empty? JF - Geosciences N2 - Arboreal epiphytes (plants residing in forest canopies) are present across all major climate zones and play important roles in forest biogeochemistry. The substantial water storage capacity per unit area of the epiphyte "bucket" is a key attribute underlying their capability to influence forest hydrological processes and their related mass and energy flows. It is commonly assumed that the epiphyte bucket remains saturated, or near-saturated, most of the time; thus, epiphytes (particularly vascular epiphytes) can store little precipitation, limiting their impact on the forest canopy water budget. We present evidence that contradicts this common assumption from (i) an examination of past research; (ii) new datasets on vascular epiphyte and epi-soil water relations at a tropical montane cloud forest (Monteverde, Costa Rica); and (iii) a global evaluation of non-vascular epiphyte saturation state using a process-based vegetation model, LiBry. All analyses found that the external and internal water storage capacity of epiphyte communities is highly dynamic and frequently available to intercept precipitation. Globally, non-vascular epiphytes spend <20% of their time near saturation and regionally, including the humid tropics, model results found that non-vascular epiphytes spend similar to 1/3 of their time in the dry state (0-10% of water storage capacity). Even data from Costa Rican cloud forest sites found the epiphyte community was saturated only 1/3 of the time and that internal leaf water storage was temporally dynamic enough to aid in precipitation interception. Analysis of the epi-soils associated with epiphytes further revealed the extent to which the epiphyte bucket emptied-as even the canopy soils were often <50% saturated (29-53% of all days observed). Results clearly show that the epiphyte bucket is more dynamic than currently assumed, meriting further research on epiphyte roles in precipitation interception, redistribution to the surface and chemical composition of "net" precipitation waters reaching the surface. KW - precipitation KW - interception KW - bromeliad KW - vascular epiphyte KW - non-vascular epiphyte KW - lichens KW - bryophytes KW - water storage capacity Y1 - 2019 U6 - https://doi.org/10.3390/geosciences9080342 SN - 2076-3263 VL - 9 IS - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Schachter, Allison T1 - Barry Trachtenberg, The Holocaust & the Exile of Yiddish: A History of the Algemeyne Entsiklopedye (New Brunswick, NJ: Rutgers University Press, 2022), 336 pp., $ 37.50 JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-585836 SN - 978-3-86956-552-1 SN - 1614-6492 SN - 1862-7684 IS - 28 SP - 121 EP - 125 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Miklashevsky, Alex A1 - Kulkova, Elena A1 - Michirev, Alexej A1 - Jeglinski-Mende, Melinda A. A1 - Bertonatti, Matias T1 - Book review on: Raab, Markus: Judgment, decision-making, and embodied choices. - London ; San Diego ; Cambridge, MA ; Oxford: Academic Press, 2020. - xv, 155 pages. - ISBN: 978-0-12-823523-2 JF - Frontiers in psychology KW - embodied cognition KW - decision making KW - embodied choice KW - book review KW - mind-body Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.665728 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Dai, Xiaolin A1 - Böker, Alexander A1 - Glebe, Ulrich T1 - Broadening the scope of sortagging JF - RSC Advances N2 - Sortases are enzymes occurring in the cell wall of Gram-positive bacteria. Sortase A (SrtA), the best studied sortase class, plays a key role in anchoring surface proteins with the recognition sequence LPXTG covalently to oligoglycine units of the bacterial cell wall. This unique transpeptidase activity renders SrtA attractive for various purposes and motivated researchers to study multiple in vivo and in vitro ligations in the last decades. This ligation technique is known as sortase-mediated ligation (SML) or sortagging and developed to a frequently used method in basic research. The advantages are manifold: extremely high substrate specificity, simple access to substrates and enzyme, robust nature and easy handling of sortase A. In addition to the ligation of two proteins or peptides, early studies already included at least one artificial (peptide equipped) substrate into sortagging reactions - which demonstrates the versatility and broad applicability of SML. Thus, SML is not only a biology-related technique, but has found prominence as a major interdisciplinary research tool. In this review, we provide an overview about the use of sortase A in interdisciplinary research, mainly for protein modification, synthesis of protein-polymer conjugates and immobilization of proteins on surfaces. Y1 - 2019 U6 - https://doi.org/10.1039/c8ra06705h SN - 2046-2069 VL - 9 IS - 9 SP - 4700 EP - 4721 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Barbolini, Natasha A1 - Woutersen, Amber A1 - Dupont-Nivet, Guillaume A1 - Silvestro, Daniele A1 - Tardif-Becquet, Delphine A1 - Coster, Pauline M. C. A1 - Meijer, Niels A1 - Chang, Cun A1 - Zhang, Hou-Xi A1 - Licht, Alexis A1 - Rydin, Catarina A1 - Koutsodendris, Andreas A1 - Han, Fang A1 - Rohrmann, Alexander A1 - Liu, Xiang-Jun A1 - Zhang, Y. A1 - Donnadieu, Yannick A1 - Fluteau, Frederic A1 - Ladant, Jean-Baptiste A1 - Le Hir, Guillaume A1 - Hoorn, M. Carina T1 - Cenozoic evolution of the steppe-desert biome in Central Asia JF - Science Advances N2 - The origins and development of the arid and highly seasonal steppe-desert biome in Central Asia, the largest of its kind in the world, remain largely unconstrained by existing records. It is unclear how Cenozoic climatic, geological, and biological forces, acting at diverse spatial and temporal scales, shaped Central Asian ecosystems through time. Our synthesis shows that the Central Asian steppe-desert has existed since at least Eocene times but experienced no less than two regime shifts, one at the Eocene-Oligocene Transition and one in the mid-Miocene. These shifts separated three successive "stable states," each characterized by unique floral and faunal structures. Past responses to disturbance in the Asian steppe-desert imply that modern ecosystems are unlikely to recover their present structures and diversity if forced into a new regime. This is of concern for Asian steppes today, which are being modified for human use and lost to desertification at unprecedented rates. Y1 - 2020 U6 - https://doi.org/10.1126/sciadv.abb8227 SN - 2375-2548 VL - 6 IS - 41 PB - American Association for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Rawel, Harshadrai Manilal A1 - Huschek, Gerd A1 - Sagu Tchewonpi, Sorel A1 - Homann, Thomas T1 - Cocoa Bean Proteins-Characterization, Changes and Modifications due to Ripening and Post-Harvest Processing JF - Nutrients N2 - The protein fractions of cocoa have been implicated influencing both the bioactive potential and sensory properties of cocoa and cocoa products. The objective of the present review is to show the impact of different stages of cultivation and processing with regard to the changes induced in the protein fractions. Special focus has been laid on the major seed storage proteins throughout the different stages of processing. The study starts with classical introduction of the extraction and the characterization methods used, while addressing classification approaches of cocoa proteins evolved during the timeline. The changes in protein composition during ripening and maturation of cocoa seeds, together with the possible modifications during the post-harvest processing (fermentation, drying, and roasting), have been documented. Finally, the bioactive potential arising directly or indirectly from cocoa proteins has been elucidated. The state of the art suggests that exploration of other potentially bioactive components in cocoa needs to be undertaken, while considering the complexity of reaction products occurring during the roasting phase of the post-harvest processing. Finally, the utilization of partially processed cocoa beans (e.g., fermented, conciliatory thermal treatment) can be recommended, providing a large reservoir of bioactive potentials arising from the protein components that could be instrumented in functionalizing foods. KW - cocoa processing KW - cocoa proteins KW - classification KW - extraction and characterization methods KW - fermentation-related enzymes KW - bioactive peptides KW - heath potentials KW - protein-phenol interactions Y1 - 2019 U6 - https://doi.org/10.3390/nu11020428 SN - 2072-6643 VL - 11 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Omranian, Sara A1 - Nikoloski, Zoran A1 - Grimm, Dominik G. T1 - Computational identification of protein complexes from network interactions: Present state, challenges, and the way forward BT - present state, challenges, and the way forward JF - Computational and structural biotechnology journal N2 - Physically interacting proteins form macromolecule complexes that drive diverse cellular processes. Advances in experimental techniques that capture interactions between proteins provide us with protein-protein interaction (PPI) networks from several model organisms. These datasets have enabled the prediction and other computational analyses of protein complexes. Here we provide a systematic review of the state-of-the-art algorithms for protein complex prediction from PPI networks proposed in the past two decades. The existing approaches that solve this problem are categorized into three groups, including: cluster-quality-based, node affinity-based, and network embedding-based approaches, and we compare and contrast the advantages and disadvantages. We further include a comparative analysis by computing the performance of eighteen methods based on twelve well-established performance measures on four widely used benchmark protein-protein interaction networks. Finally, the limitations and drawbacks of both, current data and approaches, along with the potential solutions in this field are discussed, with emphasis on the points that pave the way for future research efforts in this field. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). KW - Protein Complex Prediction KW - Protein-Protein interaction network KW - Network KW - Clustering Algorithms KW - Network embedding Y1 - 2022 U6 - https://doi.org/10.1016/j.csbj.2022.05.049 SN - 2001-0370 VL - 20 SP - 2699 EP - 2712 PB - Research Network of Computational and Structural Biotechnology (RNCSB) CY - Gotenburg ER - TY - JOUR A1 - Heyde, Jürgen T1 - Daniel B. Schwartz, Ghetto: The History of a Word (Cambridge, MA: Harvard University Press, 2019), 288 p. JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-537530 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 151 EP - 154 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Talabardon, Susanne T1 - David Biale, David Assaf, Benjamin Brown, Uriel Gellman, Samuel Heilman, Moshe Rosman, Gadi Sagiv, Marcin Wodziński, Hasidism: A New History. With an Afterword by Arthur Green (Princeton: Princeton University Press, 2018), 875 p., $ 45. JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-486164 SN - 978-3-86956-493-7 SN - 1614-6492 SN - 1862-7684 VL - 2020 IS - 26 SP - 149 EP - 152 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schulz, Michael Karl T1 - David Sorkin, Jewish Emancipation: A History across Five Centuries (Princeton/Oxford: Princeton University Press, 2019), 528 p. JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-538040 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 170 EP - 173 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ries, Rotraud T1 - Debra Kaplan, The Patrons and Their Poor: Jewish Community and Public Charity in Early Modern Germany (= Jewish Culture and Contexts), (Philadelphia: University of Pennsylvania Press, 2020), 239 p. JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-538012 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 159 EP - 162 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Wong, Kevin A1 - Mason, Emily A1 - Brune, Sascha A1 - East, Madison A1 - Edmonds, Marie A1 - Zahirovic, Sabin T1 - Deep Carbon Cycling Over the Past 200 Million Years: A Review of Fluxes in Different Tectonic Settings JF - Frontiers in Earth Science KW - deep carbon cycle KW - carbonate assimilation KW - solid Earth degassing KW - plate reconstructions KW - carbon dioxide KW - subduction zone Y1 - 2019 U6 - https://doi.org/10.3389/feart.2019.00263 SN - 2296-6463 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Petersen, Jens T1 - Die Klassiker lesen – vier Buchbesprechungen JF - Studien zur juristischen Ideengeschichte Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-604318 SN - 978-3-86956-543-9 SP - 161 EP - 176 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kleuser, Burkhard T1 - Divergent role of sphingosine 1-phosphate in liver health and disease JF - International journal of molecular sciences N2 - Two decades ago, sphingosine 1-phosphate (S1P) was discovered as a novel bioactive molecule that regulates a variety of cellular functions. The plethora of S1P-mediated effects is due to the fact that the sphingolipid not only modulates intracellular functions but also acts as a ligand of G protein-coupled receptors after secretion into the extracellular environment. In the plasma, S1P is found in high concentrations, modulating immune cell trafficking and vascular endothelial integrity. The liver is engaged in modulating the plasma S1P content, as it produces apolipoprotein M, which is a chaperone for the S1P transport. Moreover, the liver plays a substantial role in glucose and lipid homeostasis. A dysfunction of glucose and lipid metabolism is connected with the development of liver diseases such as hepatic insulin resistance, non-alcoholic fatty liver disease, or liver fibrosis. Recent studies indicate that S1P is involved in liver pathophysiology and contributes to the development of liver diseases. In this review, the current state of knowledge about S1P and its signaling in the liver is summarized with a specific focus on the dysregulation of S1P signaling in obesity-mediated liver diseases. Thus, the modulation of S1P signaling can be considered as a potential therapeutic target for the treatment of hepatic diseases. KW - sphingolipids KW - sphingosine kinase KW - fibrosis KW - non-alcoholic fatty liver disease KW - insulin resistance KW - liver fibrosis Y1 - 2018 U6 - https://doi.org/10.3390/ijms19030722 SN - 1422-0067 VL - 19 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Yarman, Aysu A1 - Jetzschmann, Katharina J. A1 - Neumann, Bettina A1 - Zhang, Xiaorong A1 - Wollenberger, Ulla A1 - Cordin, Aude A1 - Haupt, Karsten A1 - Scheller, Frieder W. T1 - Enzymes as Tools in MIP-Sensors JF - Chemosensors N2 - Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as tracers for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences. KW - enzymatic MIP synthesis KW - template digestion KW - enzyme tracer KW - enzymatic analyte conversion KW - molecularly imprinted polymers Y1 - 2017 U6 - https://doi.org/10.3390/chemosensors5020011 SN - 2227-9040 VL - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Lawrence, Mark A1 - Schäfer, Stefan A1 - Muri, Helene A1 - Scott, Vivian A1 - Oschlies, Andreas A1 - Vaughan, Naomi E. A1 - Boucher, Olivier A1 - Schmidt, Hauke A1 - Haywood, Jim A1 - Scheffran, Jürgen T1 - Evaluating climate geoengineering proposals in the context of the Paris Agreement temperature goals JF - Nature Communications N2 - Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide removal or farther-reaching interventions altering the Earth’s radiative energy budget. Although research indicates that several techniques may eventually have the physical potential to contribute to limiting climate change, all are in early stages of development, involve substantial uncertainties and risks, and raise ethical and governance dilemmas. Based on present knowledge, climate geoengineering techniques cannot be relied on to significantly contribute to meeting the Paris Agreement temperature goals. KW - Atmospheric chemistry KW - Atmospheric dynamics KW - Atmospheric science KW - Climate change KW - Environmental impact Y1 - 2018 U6 - https://doi.org/10.1038/s41467-018-05938-3 SN - 2041-1723 VL - 9 PB - Nature Publ. Group CY - London ER -