TY - JOUR A1 - Warschburger, Petra T1 - Jugendliche und junge Erwachsene mit Adipositas T1 - Adolescents and Young Adults BT - Wie sollte in ihren Augen „die perfekte Therapie“ aussehen? BT - What Would a "Perfect Therapy" Look Like? JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Hauptziel Adipositas ist eine der Hauptindikationen in der Kinder- und Jugend-Rehabilitation. Für ältere Jugendliche und junge Erwachsene fehlen altersspezifische Therapieangebote fast vollständig. Ziel war es die Wünsche bezüglich der Inhalte und Methoden einer „perfekten Therapie“ im Rahmen eines Rehabilitationsaufenthalts zu untersuchen. Methode Im Rahmen der YOUTH-Studie wurden 147 adipöse Jugendliche und junge Erwachsene beiderlei Geschlechts (zwischen 15 und 21 Jahren) mithilfe eines standardisierten Fragebogens befragt. Ergebnis Insgesamt zeigten sich relativ wenige alters- und geschlechtsspezifische Unterschiede. Interdisziplinär geleitete, koedukative Gruppen mit Elterneinbindung wurden gewünscht. Wichtige Themen waren gesunde Ernährung sowie psychosoziale Aspekte. Auch der Prävention von Rückfällen wurde eine hohe Relevanz zugeschrieben. Schlussfolgerung Psychosoziale Aspekte und die Vorbereitung auf mögliche Rückfallsituationen sollten integraler Bestandteil der Therapie sein. N2 - Principal objective Obesity is a major indication for pediatric and adolescent-rehabilitation. Age-specific therapies for „emerging adults“ are lacking. The aim was to examine the patients’ preferences with respect to the contents and methods of the „perfect therapy“ within an inpatient setting. Method In the context of the YOUTH study 147 obese male and female adolescents (aged 15–21 years) filled in standardized questionnaires. Results Overall little age- and gender-specific differences were observed. The participants expressed a preference for interdisciplinary coordinated and coeducational group approaches with involvement of the parents. Major topics were healthy nutrition and psychosocial aspects. Prevention of relapses is considered as important as well. Conclusion Psychosocial aspects and preparing coping with risk situations should be an integral part of treatment programs. KW - obesity KW - adolescents KW - young adults KW - therapy KW - requirements KW - Jugendliche KW - junge Erwachsene KW - Therapie KW - Anforderungen KW - Adipositas Y1 - 2017 U6 - https://doi.org/10.1055/s-0043-107930 SN - 0034-3536 SN - 1439-1309 VL - 57 IS - 5 SP - 295 EP - 302 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Hoffmann, Svenja Sarah Helen A1 - Cortes-Garcia, Laura A1 - Warschburger, Petra T1 - Weight/shape and muscularity concerns and emotional problems in adolescent boys and girls BT - A cross-lagged panel analysis JF - Journal of adolescence N2 - Introduction: The goal of the present study was to identify the prospective relations between weight/shape and muscularity concerns and emotional problems in adolescents. Methods: Self-report data of 966 German male and female adolescents were analyzed in a cross lagged panel design. Results: Analyses of latent means revealed significant correlations between weight/shape concern and emotional problems as well as between muscularity concern and emotional problems in both genders. Moreover, weight/shape concern predicted emotional problems prospectively, but only in girls. Regarding muscularity concern, we could not find any prospective relation with emotional problems In boys or girls from the general population. Conclusions: It is assumed that as appearance is highly relevant for the self-concept in girls, concerns about the look might promote emotional problems. Thus, weight/shape concern should be addressed in the prevention of emotional problems in adolescent girls, whereas further research is necessary investigating the contribution of muscularity concern in this context. KW - Weight/shape concern KW - Muscularity concern KW - Depressive symptoms KW - Adolescents KW - Cross-lagged panel analysis Y1 - 2018 U6 - https://doi.org/10.1016/j.adolescence.2018.07.005 SN - 0140-1971 SN - 1095-9254 VL - 68 SP - 70 EP - 77 PB - Elsevier CY - London ER - TY - JOUR A1 - Reinauer, Christina A1 - Viermann, Rabea A1 - Foertsch, Katharina A1 - Linderskamp, Hannah A1 - Warschburger, Petra A1 - Holl, Reinhard W. A1 - Staab, Doris A1 - Minden, Kirsten A1 - Muche, Rainer A1 - Domhardt, Matthias A1 - Baumeister, Harald A1 - Meissner, Thomas T1 - Motivational Interviewing as a tool to enhance access to mental health treatment in adolescents with chronic medical conditions and need for psychological support (COACH-MI) BT - study protocol for a clusterrandomised controlled trial JF - Trials N2 - Background This cluster-randomised monocentric controlled trial focuses on improving the uptake symptoms of mental health care in adolescents with chronic medical conditions who have been identified by screening to have depression or anxiety. The study aims to determine the efficacy of motivational interviewing (MI) delivered by trained physicians to increase 12- to 20-year-old adolescents’ utilisation of psychological health care for symptoms of anxiety or depression. Methods/design In this single-centre approach, n = 1,000 adolescents will be screened (using PHQ-9 and GAD-7), and adolescents with results indicative of anxiety or depressive symptoms (n = 162) will be advised to seek psychological health care in clusters from treating physicians in specialised outpatient departments. Participants who screen positive will receive either two sessions of MI or treatment as usual (TAU; regarded as the typical daily clinical practice), which is focused on recommending them to seek psychological health care for further evaluation. MI efficacy will be compared to the current TAU as the control condition. The primary outcome is the utilisation rate of psychological health care after counselling by an MI-trained physician vs. an untrained physician. Additionally, reasons for not claiming psychological support and changes in disease-related parameters will be evaluated in a 6-month follow-up session. Discussion This trial will evaluate the feasibility of MI as a way to improve the utilisation of mental health-care services by adolescents who need further support other than that provided by standard care for chronic diseases. Physicians offering MI to adolescents may serve as a model for optimising health-care management in daily clinical practice, which may improve adolescents’ long-term well-being by improving adherence to medical treatment and preventing negative lifelong consequences into adulthood. KW - Adolescents KW - adherence to medical treatment KW - anxiety KW - chronic condition KW - depression KW - motivational interviewing Y1 - 2018 U6 - https://doi.org/10.1186/s13063-018-2997-5 SN - 1745-6215 VL - 19 PB - BMC CY - London ER - TY - JOUR A1 - Hameister, Inga A1 - Nickels, Lyndsey T1 - The cat in the tree - using picture descriptions to inform our understanding of conceptualisation in aphasia JF - Language, cognition and neuroscience N2 - Conceptualisation is the first step of speech production and describes the process by which we map our thoughts onto spoken language. Recent studies suggest that some people with language impairments have conceptualisation deficits manifested by information selection and sequencing difficulties. In this study, we examined conceptualisation in the complex picture descriptions of individuals with and without aphasia. We analysed the number and the order of main concepts (ideas produced by >= 60% of unimpaired speakers) and non-main concepts (e.g. irrelevant details). Half of the individuals with aphasia showed a reduced number of main concepts that could not be fully accounted for by their language production deficits. Moreover, individuals with aphasia produced both a larger amount of marginally relevant information, as well as having greater variability in the order of main concepts. Both findings provide support for the idea that conceptualisation deficits are a relatively common impairment in people with aphasia. KW - Aphasia KW - conceptualisation KW - discourse KW - concept analysis KW - macroplanning Y1 - 2018 U6 - https://doi.org/10.1080/23273798.2018.1497801 SN - 2327-3798 SN - 2327-3801 VL - 33 IS - 10 SP - 1296 EP - 1314 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Gmeiner, Michaela Silvia A1 - Warschburger, Petra T1 - Intrapersonal predictors of weight bias internalization among elementary school children BT - a prospective analysis JF - BMC Pediatrics N2 - Background Weight-related stigmatization is a widespread problem. Particularly the internalization of weight-related stereotypes and prejudices (weight bias internalization, WBI) is related to mental and physical health impairments. To date, little is known about the risk factors of WBI. Previous studies are mainly cross-sectional and based on adult samples. As childhood is a sensitive period for the development of a healthy self-concept, we examined predictors of WBI in children. Methods The final sample included 1,463 schoolchildren (6–11 years, 51.7% female) who took part in a prospective study consisting of three measurement waves. The first two waves delivered data on objective weight status and self-reported weight-related teasing, body dissatisfaction, relevance of one’s own figure, self-esteem and depressive symptoms; WBI was measured during the third wave. To examine predictors of WBI, we ran hierarchical regression analyses and exploratory mediation analyses. Results Lower parental education level, higher child weight status, female gender, experience of teasing, higher body dissatisfaction, higher figure-relevance, and higher depression scores were found to be predictive for higher WBI scores. Body dissatisfaction (only for girls) and the relevance of one’s own figure (both genders) mediated the association between self-esteem and WBI; no weight-related differences were observed. Conclusions Our study offers longitudinal evidence for variables that enable the identification of children who are at risk for WBI. Thus, the findings deliver starting points for interventions aimed at the prevention of adverse health developments that come along with WBI. KW - Weight bias internalization KW - Self-stigmatization KW - Weight KW - Children KW - Predictors Y1 - 2020 U6 - https://doi.org/10.1186/s12887-020-02264-w SN - 1471-2431 VL - 20 PB - BioMed Central CY - London ER - TY - JOUR A1 - Boll-Avetisyan, Natalie A1 - Bhatara, Anjali A1 - Höhle, Barbara T1 - Processing of rhythm in speech and music in adult dyslexia JF - Brain Sciences N2 - Recent studies have suggested that musical rhythm perception ability can affect the phonological system. The most prevalent causal account for developmental dyslexia is the phonological deficit hypothesis. As rhythm is a subpart of phonology, we hypothesized that reading deficits in dyslexia are associated with rhythm processing in speech and in music. In a rhythmic grouping task, adults with diagnosed dyslexia and age-matched controls listened to speech streams with syllables alternating in intensity, duration, or neither, and indicated whether they perceived a strong-weak or weak-strong rhythm pattern. Additionally, their reading and musical rhythm abilities were measured. Results showed that adults with dyslexia had lower musical rhythm abilities than adults without dyslexia. Moreover, lower musical rhythm ability was associated with lower reading ability in dyslexia. However, speech grouping by adults with dyslexia was not impaired when musical rhythm perception ability was controlled: like adults without dyslexia, they showed consistent preferences. However, rhythmic grouping was predicted by musical rhythm perception ability, irrespective of dyslexia. The results suggest associations among musical rhythm perception ability, speech rhythm perception, and reading ability. This highlights the importance of considering individual variability to better understand dyslexia and raises the possibility that musical rhythm perception ability is a key to phonological and reading acquisition. KW - developmental dyslexia KW - Iambic/Trochaic Law KW - rhythmic grouping KW - musicality KW - speech perception KW - rhythm perception Y1 - 2020 U6 - https://doi.org/10.3390/brainsci10050261 SN - 2076-3425 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Miklashevsky, Alex A1 - Fischer, Martin H. A1 - Lindemann, Oliver T1 - Spatial-numerical associations without a motor response? Grip force says ‘Yes’ JF - Acta Psychologica N2 - In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task (“Is it a number or a letter?”). In Experiment 2, we used a deeper semantic task (“Is this number larger or smaller than five?”). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500–700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words). KW - SNARC KW - Mental number line KW - Number processing KW - Embodied cognition KW - Grip force KW - Motor system Y1 - 2022 U6 - https://doi.org/10.1016/j.actpsy.2022.103791 SN - 1873-6297 VL - 231 SP - 1 EP - 17 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Göldel, Julia M. A1 - Kamrath, Clemens A1 - Minden, Kirsten A1 - Wiegand, Susanna A1 - Lanzinger, Stefanie A1 - Sengler, Claudia A1 - Weihrauch-Blüher, Susann A1 - Holl, Reinhard W. A1 - Tittel, Sascha René A1 - Warschburger, Petra T1 - Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany JF - Children N2 - This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0–10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1%, JIA 11.1%, obesity 20%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6%; obesity 13.1%; JIA 5%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany. KW - chronic health condition KW - children and adolescents KW - health care KW - COVID-19 pandemic KW - diabetes KW - rheumatic diseases KW - obesity Y1 - 2022 U6 - https://doi.org/10.3390/children10010010 SN - 2227-9067 VL - 10 SP - 1 EP - 11 PB - MDPI CY - Basel, Schweiz ET - 1 ER - TY - JOUR A1 - Kühne, Franziska A1 - Fauth, Henriette A1 - Destina Sevde, Ay-Bryson A1 - Visser, Leonie N.C. A1 - Weck, Florian T1 - Communicating the diagnosis of cancer or depression: Results of a randomized controlled online study using video vignettes JF - Cancer Medicine N2 - Background Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study. Methods Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied. Results Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61–1.06). Conclusions The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer. KW - consultation KW - mental health KW - oncology KW - psycho-oncology KW - skills Y1 - 2021 U6 - https://doi.org/10.1002/cam4.4396 SN - 2045-7634 VL - 10 SP - 9012 EP - 9021 PB - Wiley CY - Hoboken, New Jersey, USA ET - 24 ER - TY - JOUR A1 - Kayhan, Ezgi A1 - Matthes, Daniel A1 - Marriott Haresign, Ira A1 - Bánki, Anna A1 - Michel, Christine A1 - Langeloh, Miriam A1 - Wass, Sam A1 - Hoehl, Stefanie T1 - DEEP: A dual EEG pipeline for developmental hyperscanning studies JF - Developmental Cognitive Neuroscience N2 - Cutting-edge hyperscanning methods led to a paradigm shift in social neuroscience. It allowed researchers to measure dynamic mutual alignment of neural processes between two or more individuals in naturalistic contexts. The ever-growing interest in hyperscanning research calls for the development of transparent and validated data analysis methods to further advance the field. We have developed and tested a dual electroencephalography (EEG) analysis pipeline, namely DEEP. Following the preprocessing of the data, DEEP allows users to calculate Phase Locking Values (PLVs) and cross-frequency PLVs as indices of inter-brain phase alignment of dyads as well as time-frequency responses and EEG power for each participant. The pipeline also includes scripts to control for spurious correlations. Our goal is to contribute to open and reproducible science practices by making DEEP publicly available together with an example mother-infant EEG hyperscanning dataset. KW - Developmental hyperscanning KW - Dual EEG analysis KW - Adult-child interaction KW - Phase Locking Value KW - PLV KW - Cross-frequency PLV KW - FieldTrip Y1 - 2022 U6 - https://doi.org/10.1016/j.dcn.2022.101104 SN - 1878-9307 VL - 54 SP - 1 EP - 11 PB - Elsevier CY - Amsterdam, Niederlande ER - TY - GEN A1 - Kulkova, Elena S. A1 - Fischer, Martin H. T1 - Idioms in the World BT - A Focus on Processing T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 561 KW - embodiment KW - figurative language KW - metaphor KW - idiom KW - processing Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435704 SN - 1866-8364 IS - 561 ER - TY - JOUR A1 - Sauermann, Antje A1 - Höhle, Barbara T1 - Word order in German child language and child-directed speech BT - a corpus analysis on the ordering of double objects in the German middlefield JF - Glossa: A Journal of General Linguistics N2 - We report two corpus analyses to examine the impact of animacy, definiteness, givenness and type of referring expression on the ordering of double objects in the spontaneous speech of German-speaking two- to four-year-old children and the child-directed speech of their mothers. The first corpus analysis revealed that definiteness, givenness and type of referring expression influenced word order variation in child language and child-directed speech when the type of referring expression distinguished between pronouns and lexical noun phrases. These results correspond to previous child language studies in English (e.g., de Marneffe et al. 2012). Extending the scope of previous studies, our second corpus analysis examined the role of different pronoun types on word order. It revealed that word order in child language and child-directed speech was predictable from the types of pronouns used. Different types of pronouns were associated with different sentence positions but also showed a strong correlation to givenness and definiteness. Yet, the distinction between pronoun types diminished the effects of givenness so that givenness had an independent impact on word order only in child-directed speech but not in child language. Our results support a multi-factorial approach to word order in German. Moreover, they underline the strong impact of the type of referring expression on word order and suggest that it plays a crucial role in the acquisition of the factors influencing word order variation. KW - German KW - word order KW - corpus study KW - language acquisition KW - information structure KW - referring expression Y1 - 2018 U6 - https://doi.org/10.5334/gjgl.281 SN - 2397-1835 VL - 3 IS - 1 PB - Ubiquity Press LTD CY - London ER - TY - JOUR A1 - Miklashevsky, Alex T1 - Catch the star! Spatial information activates the manual motor system JF - PLoS ONE N2 - Previous research demonstrated a close bidirectional relationship between spatial attention and the manual motor system. However, it is unclear whether an explicit hand movement is necessary for this relationship to appear. A novel method with high temporal resolution–bimanual grip force registration–sheds light on this issue. Participants held two grip force sensors while being presented with lateralized stimuli (exogenous attentional shifts, Experiment 1), left- or right-pointing central arrows (endogenous attentional shifts, Experiment 2), or the words "left" or "right" (endogenous attentional shifts, Experiment 3). There was an early interaction between the presentation side or arrow direction and grip force: lateralized objects and central arrows led to a larger increase of the ipsilateral force and a smaller increase of the contralateral force. Surprisingly, words led to the opposite pattern: larger force increase in the contralateral hand and smaller force increase in the ipsilateral hand. The effect was stronger and appeared earlier for lateralized objects (60 ms after stimulus presentation) than for arrows (100 ms) or words (250 ms). Thus, processing visuospatial information automatically activates the manual motor system, but the timing and direction of this effect vary depending on the type of stimulus. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0262510 SN - 1932-6203 SP - 1 EP - 30 PB - PLOS CY - San Francisco, California, US ER - TY - JOUR A1 - Niesta Kayser, Daniela A1 - Graupmann, Verena A1 - Fryer, James W. A1 - Frey, Dieter T1 - Threat to Freedom and the Detrimental Effect of Avoidance Goal Frames BT - Reactance as a Mediating Variable JF - Frontiers in psychology N2 - Two experiments examined how individuals respond to a restriction presented within an approach versus an avoidance frame. In Study 1, working on a problem-solving task, participants were initially free to choose their strategy, but for a second task were told to change their strategy. The message to change was embedded in either an approach or avoidance frame. When confronted with an avoidance compared to an approach frame, the participants’ reactance toward the request was greater and, in turn, led to impaired performance. The role of reactance as a response to threat to freedom was explicitly examined in Study 2, in which participants evaluated a potential change in policy affecting their program of study herein explicitly varying whether a restriction was present or absent and whether the message was embedded in an approach versus avoidance frame. When communicated with an avoidance frame and as a restriction, participants showed the highest resistance in terms of reactance, message agreement and evaluation of the communicator. The difference in agreement with the change was mediated by reactance only when a restriction was present. Overall, avoidance goal frames were associated with more resistance to change on different levels of experience (reactance, performance, and person perception). Reactance mediated the effect of goal frame on other outcomes only when a restriction was present. KW - freedom restriction KW - goal frames KW - avoidance KW - approach KW - reactance KW - self threat KW - change Y1 - 2016 U6 - https://doi.org/10.3389/fpsyg.2016.00632 SN - 1664-1078 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - THES A1 - Hanne, Sandra T1 - On the subject-object asymmetry in sentence comprehension in aphasia BT - implications from eye-tracking data and computational modeling Y1 - 2015 ER - TY - JOUR A1 - Sixtus, Elena A1 - Fischer, Martin H. T1 - Eine kognitionswissenschaftliche Betrachtung der Konzepte "Raum" und "Zahl" JF - Raum und Zahl im Fokus der Wissenschaften : eine multidisziplinäre Vorlesungsreihe Y1 - 2015 SN - 978-3-86464-082-7 SP - 35 EP - 62 PB - Trafo CY - Berlin ER - TY - JOUR A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Competing Biases in Mental Arithmetic BT - When Division Is More and Multiplication Is Less JF - Frontiers in human neuroscience N2 - Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such “operational momentum” (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic. KW - heuristics and biases KW - numerical cognition KW - mental arithmetic KW - mental number line KW - operational momentum Y1 - 2017 U6 - https://doi.org/10.3389/fnhum.2017.00037 SN - 1662-5161 VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Competing Biases in Mental Arithmetic BT - When Division Is More and Multiplication Is Less N2 - Mental arithmetic exhibits various biases. Among those is a tendency to overestimate addition and to underestimate subtraction outcomes. Does such “operational momentum” (OM) also affect multiplication and division? Twenty-six adults produced lines whose lengths corresponded to the correct outcomes of multiplication and division problems shown in symbolic format. We found a reliable tendency to over-estimate division outcomes, i.e., reverse OM. We suggest that anchoring on the first operand (a tendency to use this number as a reference for further quantitative reasoning) contributes to cognitive biases in mental arithmetic. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 312 KW - heuristics and biases KW - mental arithmetic KW - mental number line KW - numerical cognition KW - operational momentum Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-103492 ER - TY - JOUR A1 - Warschburger, Petra A1 - Kröller, Katja T1 - Loss to follow-up in a randomized controlled trial study for pediatric weight management (EPOC) JF - BMC pediatrics N2 - Background Attrition is a serious problem in intervention studies. The current study analyzed the attrition rate during follow-up in a randomized controlled pediatric weight management program (EPOC study) within a tertiary care setting. Methods Five hundred twenty-three parents and their 7–13-year-old children with obesity participated in the randomized controlled intervention trial. Follow-up data were assessed 6 and 12 months after the end of treatment. Attrition was defined as providing no objective weight data. Demographic and psychological baseline characteristics were used to predict attrition at 6- and 12-month follow-up using multivariate logistic regression analyses. Results Objective weight data were available for 49.6 (67.0) % of the children 6 (12) months after the end of treatment. Completers and non-completers at the 6- and 12-month follow-up differed in the amount of weight loss during their inpatient stay, their initial BMI-SDS, educational level of the parents, and child’s quality of life and well-being. Additionally, completers supported their child more than non-completers, and at the 12-month follow-up, families with a more structured eating environment were less likely to drop out. On a multivariate level, only educational background and structure of the eating environment remained significant. Conclusions The minor differences between the completers and the non-completers suggest that our retention strategies were successful. Further research should focus on prevention of attrition in families with a lower educational background. KW - Attrition KW - Obesity KW - Child KW - Predictors KW - Weight management trial Y1 - 2016 U6 - https://doi.org/10.1186/s12887-016-0727-2 SN - 1471-2431 VL - 16 PB - BioMed Central CY - London ER - TY - GEN A1 - Warschburger, Petra A1 - Kröller, Katja T1 - Loss to follow-up in a randomized controlled trial study for pediatric weight management (EPOC) N2 - Background Attrition is a serious problem in intervention studies. The current study analyzed the attrition rate during follow-up in a randomized controlled pediatric weight management program (EPOC study) within a tertiary care setting. Methods Five hundred twenty-three parents and their 7–13-year-old children with obesity participated in the randomized controlled intervention trial. Follow-up data were assessed 6 and 12 months after the end of treatment. Attrition was defined as providing no objective weight data. Demographic and psychological baseline characteristics were used to predict attrition at 6- and 12-month follow-up using multivariate logistic regression analyses. Results Objective weight data were available for 49.6 (67.0) % of the children 6 (12) months after the end of treatment. Completers and non-completers at the 6- and 12-month follow-up differed in the amount of weight loss during their inpatient stay, their initial BMI-SDS, educational level of the parents, and child’s quality of life and well-being. Additionally, completers supported their child more than non-completers, and at the 12-month follow-up, families with a more structured eating environment were less likely to drop out. On a multivariate level, only educational background and structure of the eating environment remained significant. Conclusions The minor differences between the completers and the non-completers suggest that our retention strategies were successful. Further research should focus on prevention of attrition in families with a lower educational background. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 307 KW - Attrition KW - Child KW - Obesity KW - Predictors KW - Weight management trial Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-100359 ER - TY - THES A1 - Gendt, Anja T1 - Eye movements under the control of working memory : the challenge of a reading-span task T1 - Blickbewegungen unter Arbeitsgedächtniskontrolle : Die Herausforderungen einer Lesespannenaufgabe N2 - During reading oculomotor processes guide the eyes over the text. The visual information recorded is accessed, evaluated and processed. Only by retrieving the meaning of a word from the long-term memory, as well as through the connection and storage of the information about each individual word, is it possible to access the semantic meaning of a sentence. Therefore memory, and here in particular working memory, plays a pivotal role in the basic processes of reading. The following dissertation investigates to what extent different demands on memory and memory capacity have an effect on eye movement behavior while reading. The frequently used paradigm of the reading span task, in which test subjects read and evaluate individual sentences, was used for the experimental review of the research questions. The results speak for the fact that working memory processes have a direct effect on various eye movement measurements. Thus a high working memory load, for example, reduced the perceptual span while reading. The lower the individual working memory capacity of the reader was, the stronger was the influence of the working memory load on the processing of the sentence. N2 - Beim Lesen steuern okulomotorische Prozesse die Blickbewegungen über den Text. Die aufgenommenen visuellen Informationen werden erschlossen, beurteilt und verarbeitet. Erst durch den Abruf der Wortbedeutung aus dem Langzeitgedächtnis, und die Verknüpfung sowie Speicherung der einzelnen Wortinformationen erschließt sich die semantische Bedeutung eines Satzes. Somit stellt das Gedächtnis und hier insbesondere das Arbeitsgedächtnis eines der grundlegenden Prozesse für das Lesen dar. Die vorliegende Dissertation untersucht inwieweit sich unterschiedliche Gedächtnisanforderungen und Gedächtniskapazitäten auf das Blickverhalten während des Lesens auswirken. Für die experimentelle Überprüfung der Forschungsfragen wurde das in der Arbeitsgedächtnisforschung sehr häufig genutzte Paradigma der Lesespannenaufgabe verwendet, bei dem Probanden einzelne Sätze lesen und beurteilen. Die Ergebnisse sprechen für einen direkten Einfluss von Arbeitsgedächtnisprozessen auf verschiedene Blickbewegungsmaße. So reduzierte eine hohe Arbeitsgedächtnisbelastung beispielsweise die perzeptuelle Spanne während des Lesens. Je geringer die individuelle Arbeitsgedächtniskapazität des Lesers war, desto stärker war der Einfluss der Arbeitsgedächtnisbelastung auf die Satzverarbeitung. KW - Blickbewegungen KW - Arbeitsgedächtnis KW - Lesen KW - Lesespanne KW - eye movements KW - working memory KW - reading KW - reading-span Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-69224 ER - TY - THES A1 - Poltrock, Silvana T1 - About the relation between implicit Theory of Mind & the comprehension of complement sentences T1 - Über den Zusammenhang zwischen impliziter Theory of Mind und dem Verstehen von Komplementsatzstrukturen N2 - Previous studies on the relation between language and social cognition have shown that children’s mastery of embedded sentential complements plays a causal role for the development of a Theory of Mind (ToM). Children start to succeed on complementation tasks in which they are required to report the content of an embedded clause in the second half of the fourth year. Traditional ToM tasks test the child’s ability to predict that a person who is holding a false belief (FB) about a situation will act "falsely". In these task, children do not represent FBs until the age of 4 years. According the linguistic determinism hypothesis, only the unique syntax of complement sentences provides the format for representing FBs. However, experiments measuring children’s looking behavior instead of their explicit predictions provided evidence that already 2-year olds possess an implicit ToM. This dissertation examined the question of whether there is an interrelation also between implicit ToM and the comprehension of complement sentences in typically developing German preschoolers. Two studies were conducted. In a correlational study (Study 1 ), 3-year-old children’s performance on a traditional (explicit) FB task, on an implicit FB task and on language tasks measuring children’s comprehension of tensed sentential complements were collected and tested for their interdependence. Eye-tracking methodology was used to assess implicit ToM by measuring participants’ spontaneous anticipatory eye movements while they were watching FB movies. Two central findings emerged. First, predictive looking (implicit ToM) was not correlated with complement mastery, although both measures were associated with explicit FB task performance. This pattern of results suggests that explicit, but not implicit ToM is language dependent. Second, as a group, 3-year-olds did not display implicit FB understanding. That is, previous findings on a precocious reasoning ability could not be replicated. This indicates that the characteristics of predictive looking tasks play a role for the elicitation of implicit FB understanding as the current task was completely nonverbal and as complex as traditional FB tasks. Study 2 took a methodological approach by investigating whether children display an earlier comprehension of sentential complements when using the same means of measurement as used in experimental tasks tapping implicit ToM, namely anticipatory looking. Two experiments were conducted. 3-year-olds were confronted either with a complement sentence expressing the protagonist’s FB (Exp. 1) or with a complex sentence expressing the protagonist’s belief without giving any information about the truth/ falsity of the belief (Exp. 2). Afterwards, their expectations about the protagonist’s future behavior were measured. Overall, implicit measures reveal no considerably earlier understanding of sentential complementation. Whereas 3-year-olds did not display a comprehension of complex sentences if these embedded a false proposition, children from 3;9 years on were proficient in processing complement sentences if the truth value of the embedded proposition could not be evaluated. This pattern of results suggests that (1) the linguistic expression of a person’s FB does not elicit implicit FB understanding and that (2) the assessment of the purely syntactic understanding of complement sentences is affected by competing reality information. In conclusion, this dissertation found no evidence that the implicit ToM is related to the comprehension of sentential complementation. The findings suggest that implicit ToM might be based on nonlinguistic processes. Results are discussed in the light of recently proposed dual-process models that assume two cognitive mechanisms that account for different levels of ToM task performance. N2 - Zahlreiche Studien legen nahe, dass der Erwerb finiter Komplementsatzstrukturen eine Voraussetzung für die Entwicklung einer Theory of Mind (ToM) ist. Kinder beginnen in circa der zweiten Hälfte ihres 4. Lebensjahres Komplementsatzverständnisaufgaben zu lösen, die eine Wiedergabe des Komplementsatzes erfordern. Die ToM wird klassischerweise als erworben bezeichnet, wenn ein Kind korrekt vorhersagen kann, dass eine Person, die eine falsche Überzeugung hat, entsprechend "falsch" handeln wird. Es ist bekannt, dass sich diese Fähigkeit bei Kindern mit circa 4 Jahren entwickelt. Gemäß der Hypothese des linguistischen Determinismus liefert die syntaktische Komplexität von Komplementsatzstrukturen das Format, um falsche Überzeugungen mental zu repräsentieren. In ToM Aufgaben, die erfassen, wo Kinder eine zukünfige Handlung einer fehlinformierten Person antizipieren, konnte allerdings bereits schon bei 2-Jährigen das Verstehen falscher Überzeugungen nachgewiesen werden. Diese frühe Fähigkeit wird auch implizite ToM genannt, da diese Art der Aufgabe keine bewusste Entscheidung verlangt. Die vorliegende Dissertation untersucht erstmalig im Deutschen, ob der Zusammenhang zwischen dem Verstehen von Komplementsatzstrukturen und ToM auch für diese implizite Fähigkeit gilt. Zwei Studien wurden durchgeführt. In Studie 1 wurden die Leistungen von 3-Jährigen in einer klassischen (expliziten) ToM Aufgabe, einer impliziten ToM Aufgabe und in Komplementsatzverständnisaufgaben erhoben und auf korrelative Zusammenhänge hin getestet. Dabei wurde mittels eines Eye-Trackers das antizipative Blickverhalten gemessen und somit auf das Vorhandensein einer impliziten ToM geschlossen. Die Leistungen in den Sprachaufgaben korrelierten nicht mit den Blickdaten, obwohl beide Maße mit den Leistungen in der expliziten ToM Aufgabe in Beziehung standen. Unerwarteterweise konnte jedoch generell kein implizites Verstehen falscher Überzeugungen bei 3-jährigen nachgewiesen werden. Da die implizite ToM Aufgabe nichtsprachlich war, wird der Einfluss von Aufgabeneigenschaften auf die Elizitierung von impliziter ToM diskutiert. Studie 2 untersuchte, ob 3-Jährige ein früheres, implizites Verstehen von Komplementsatzstrukturen in Aufgaben zeigen, in denen antizipatorische Blicke anstelle von expliziten Antworten gemessen werden und damit das gleiche Maß verwendet wird wie in impliziten ToM Aufgaben. Zwei Experimente wurden durchgeführt. Der präsentierte Komplementsatz drückte entweder eine falsche Überzeugung des Protagonisten aus (Exp. 1) oder eine Überzeugung, deren Wahrheitsgehalt nicht bestimmt wurde (Exp. 2). Während bei 3-Jährigen kein Verstehen von Komplementsatzstrukturen, die eine falsche Proposition enthielten, nachgewiesen werden konnte, zeigten Kinder ab einem Alter von 3;9 Jahren, dass sie den komplexen Satz verarbeiten, wenn dieser keine falsche Proposition beinhaltet. Dieses Ergebnismuster spricht dafür, dass (1) der sprachliche Ausdruck einer falschen Überzeugung die implizite ToM nicht elizitieren kann und dass (2) das Erfassen des rein syntaktischen Verstehens durch zusätzliche Realitätsinformation beeinträchtigt wird. Zusammenfassend konnte in der vorliegenden Arbeit kein Hinweis dafür gefunden werden, dass die implizite ToM in gleicher Weise wie die explizite ToM mit dem Verstehen von Komplementsatzstrukturen einhergeht. Die Ergebnisse legen nahe, dass vielmehr nonlinguistische Faktoren bei der Entwicklung einer impliziten ToM eine Rolle spielen könnten. Die Resultate werden mit Blick auf aktuelle Zwei-Prozess-Modelle diskutiert. KW - Theory of Mind KW - Komplementsatzverstehen KW - linguistische Determinismushypothese KW - implizit KW - Blickbewegungsmessung KW - theory of mind KW - comprehension of complement sentences KW - linguistic determinism KW - implicit KW - eye tracking Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-52293 ER - TY - THES A1 - Negri, Michael T1 - How coaches influence referee decisions BT - a principal-agent perspective on non-professional soccer BT - eine Prinzipal-Agent Perspektive auf den nicht-professionellen Fußball N2 - The work elaborates on the question if coaches in non-professional soccer can influence referee decisions. Modeled from a principal-agent perspective, the managing referee boards can be seen as the principal. They aim at facilitating a fair competition which is in accordance with the existing rules and regulations. In doing so, the referees are assigned as impartial agents on the pitch. The coaches take over a non-legitimate principal-like role trying to influence the referees even though they do not have the formal right to do so. Separate questionnaires were set up for referees and coaches. The coach questionnaire aimed at identifying the extent and the forms of influencing attempts by coaches. The referee questionnaire tried to elaborate on the questions if referees take notice of possible influencing attempts and how they react accordingly. The results were put into relation with official match data in order to identify significant influences on personal sanctions (yellow cards, second yellow cards, red cards) and the match result. It is found that there is a slight effect on the referee’s decisions. However, this effect is rather disadvantageous for the influencing coach and there is no evidence for an impact on the match result itself. N2 - Die Arbeit untersucht die Frage, ob Trainer im nicht-professionellen Fußball Schiedsrichterentscheidungen beeinflussen können. Aufbauend auf einer Prinzipal-Agent Perspektive nehmen die Schiedsrichterausschüsse die Rolle des Prinzipals ein. Sie zielen darauf ab, einen fairen Wettkampf zu organisieren, der in Übereinstimmung mit dem geltenden Regelwerk durchgeführt wird. Um dies zu erreichen, werden die Schiedsrichter als unparteiische Agenten auf dem Spielfeld eingesetzt. Die Trainer nehmen in dieser Konstellation eine illegitime, prinzipal-ähnliche Rolle ein und versuchen, den Schiedsrichter zu ihren Gunsten zu beeinflussen. Dies geschieht, ohne dass die Trainer ein entsprechendes Recht dazu hätten. Sowohl für die Trainer als auch für die Schiedsrichter wurde ein Fragebogen entworfen. Der erstgenannte zielt darauf ab, das Ausmaß und die Form von Beeinflussungsversuchen zu erheben. Der Schiedsrichter-Fragebogen hingegen erörtert die Fragen, ob die Unparteiischen mögliche Beeinflussungsversuche durch die Trainer wahrnehmen und wie sie gegebenenfalls darauf reagieren. Die Ergebnisse wurden mit offiziellen Spieldaten in Verbindung gebracht um potentielle Einflüsse auf Spiele (persönliche Strafen sowie das Endergebnis) zu identifizieren. Es wurde herausgefunden, dass es einen leichten Effekt auf Schiedsrichterentscheidungen gibt. Dieser ist zumeist jedoch nachteilig für den jeweiligen Trainer und es gibt kein Indiz für einen Einfluss auf das Endergebnis. T2 - Wie Trainer Schiedsrichterentscheidungen beeinflussen KW - referees KW - decision making KW - soccer KW - bias KW - Schiedsrichter KW - Trainer KW - Entscheidungen KW - Urteilsverzerrung KW - Prinzipal-Agent Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-72247 ER - TY - JOUR A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Rabe, Sophie A1 - Mueller, Steffen A1 - Mayer, Frank A1 - Wochatz, Monique A1 - Hadzic, Miralem A1 - John, Michael A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement BT - Randomized Controlled Trial JF - JMIR Rehabilitation and Assistive Technologies N2 - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare. Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare. Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints. Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note. Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare. KW - telerehabilitation KW - home-based KW - total hip replacement KW - total knee replacement KW - exercise therapy KW - aftercare KW - rehabilitation Y1 - 2019 U6 - https://doi.org/10.2196/14236 SN - 2369-2529 VL - 6 IS - 2 PB - jmir rehab CY - Toronto ER - TY - JOUR A1 - Salzwedel, Annett A1 - Reibis, Rona Katharina A1 - Hadzic, Miralem A1 - Buhlert, Hermann A1 - Völler, Heinz T1 - Patients’ expectations of returning to work, co-morbid disorders and work capacity at discharge from cardiac rehabilitation JF - Vascular Health and Risk Management N2 - Objective: We aimed to characterize patients after an acute cardiac event regarding their negative expectations around returning to work and the impact on work capacity upon discharge from cardiac rehabilitation (CR). Methods: We analyzed routine data of 884 patients (52±7 years, 76% men) who attended 3 weeks of inpatient CR after an acute coronary syndrome (ACS) or cardiac surgery between October 2013 and March 2015. The primary outcome was their status determining their capacity to work (fit vs unfit) at discharge from CR. Further, sociodemographic data (eg, age, sex, and education level), diagnoses, functional data (eg, exercise stress test and 6-min walking test [6MWT]), the Hospital Anxiety and Depression Scale (HADS) and self-assessment of the occupational prognosis (negative expectations and/or unemployment, Würzburger screening) at admission to CR were considered. Results: A negative occupational prognosis was detected in 384 patients (43%). Out of these, 368 (96%) expected not to return to work after CR and/or were unemployed before CR at 29% (n=113). Affected patients showed a reduced exercise capacity (bicycle stress test: 100 W vs 118 W, P<0.01; 6MWT: 380 m vs 421 m, P<0.01) and were more likely to receive a depression diagnosis (12% vs 3%, P<0.01), as well as higher levels on the HADS. At discharge from CR, 21% of this group (n=81) were fit for work (vs 35% of patients with a normal occupational prognosis (n=175, P<0.01)). Sick leave before the cardiac event (OR 0.4, 95% CI 0.2–0.6, P<0.01), negative occupational expectations (OR 0.4, 95% CI 0.3–0.7, P<0.01) and depression (OR 0.3, 95% CI 0.1–0.8, P=0.01) reduced the likelihood of achieving work capacity upon discharge. In contrast, higher exercise capacity was positively associated. Conclusion: Patients with a negative occupational prognosis often revealed a reduced physical performance and suffered from a high psychosocial burden. In addition, patients’ occupational expectations were a predictor of work capacity at discharge from CR. Affected patients should be identified at admission to allow for targeted psychosocial care. KW - cardiac rehabilitation KW - return to work KW - work capacity KW - negative expectation KW - occupational prognosis Y1 - 2019 U6 - https://doi.org/10.2147/VHRM.S216039 SN - 1176-6344 SN - 1178-2048 VL - 15 SP - 301 EP - 308 PB - Dove Medical Press CY - Albany, Auckland ER - TY - JOUR A1 - EL-Ashker, Said A1 - Chaabene, Helmi A1 - Prieske, Olaf T1 - Maximal isokinetic elbow and knee flexor–extensor strength measures in combat sports athletes: the role of movement velocity and limb side JF - BMC Sports Science, Medicine and Rehabilitation N2 - Background Maximal isokinetic strength ratios of joint flexors and extensors are important parameters to indicate the level of muscular balance at the joint. Further, in combat sports athletes, upper and lower limb muscle strength is affected by the type of sport. Thus, this study aimed to examine the differences in maximal isokinetic strength of the flexors and extensors and the corresponding flexor–extensor strength ratios of the elbows and knees in combat sports athletes. Method Forty male participants (age = 22.3 ± 2.5 years) from four different combat sports (amateur boxing, taekwondo, karate, and judo; n = 10 per sport) were tested for eccentric peak torque of the elbow/knee flexors (EF/KF) and concentric peak torque of the elbow/knee extensors (EE/KE) at three different angular velocities (60, 120, and 180°/s) on the dominant and non-dominant side using an isokinetic device. Results Analyses revealed significant, large-sized group × velocity × limb interactions for EF, EE, and EF–EE ratio, KF, KE, and KF–KE ratio (p ≤ 0.03; 0.91 ≤ d ≤ 1.75). Post-hoc analyses indicated that amateur boxers displayed the largest EE strength values on the non-dominant side at ≤ 120°/s and the dominant side at ≥ 120°/s (p < 0.03; 1.21 ≤ d ≤ 1.59). The largest EF–EE strength ratios were observed on amateur boxers’ and judokas’ non-dominant side at ≥ 120°/s (p < 0.04; 1.36 ≤ d ≤ 2.44). Further, we found lower KF–KE strength measures in karate (p < 0.04; 1.12 ≤ d ≤ 6.22) and judo athletes (p ≤ 0.03; 1.60 ≤ d ≤ 5.31) particularly on the non-dominant side. Conclusions The present findings indicated combat sport-specific differences in maximal isokinetic strength measures of EF, EE, KF, and KE particularly in favor of amateur boxers on the non-dominant side. KW - Dynamometry KW - Martial arts KW - Hamstring-quadriceps ratio KW - Eccentric muscle action KW - Injury Y1 - 2022 U6 - https://doi.org/10.1186/s13102-022-00432-2 SN - 1758-2555 VL - 13 PB - Springer Nature CY - London ER - TY - GEN A1 - Salzwedel, Annett A1 - Reibis, Rona Katharina A1 - Hadzic, Miralem A1 - Buhlert, Hermann A1 - Völler, Heinz T1 - Patients’ expectations of returning to work, co-morbid disorders and work capacity at discharge from cardiac rehabilitation T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Objective: We aimed to characterize patients after an acute cardiac event regarding their negative expectations around returning to work and the impact on work capacity upon discharge from cardiac rehabilitation (CR). Methods: We analyzed routine data of 884 patients (52±7 years, 76% men) who attended 3 weeks of inpatient CR after an acute coronary syndrome (ACS) or cardiac surgery between October 2013 and March 2015. The primary outcome was their status determining their capacity to work (fit vs unfit) at discharge from CR. Further, sociodemographic data (eg, age, sex, and education level), diagnoses, functional data (eg, exercise stress test and 6-min walking test [6MWT]), the Hospital Anxiety and Depression Scale (HADS) and self-assessment of the occupational prognosis (negative expectations and/or unemployment, Würzburger screening) at admission to CR were considered. Results: A negative occupational prognosis was detected in 384 patients (43%). Out of these, 368 (96%) expected not to return to work after CR and/or were unemployed before CR at 29% (n=113). Affected patients showed a reduced exercise capacity (bicycle stress test: 100 W vs 118 W, P<0.01; 6MWT: 380 m vs 421 m, P<0.01) and were more likely to receive a depression diagnosis (12% vs 3%, P<0.01), as well as higher levels on the HADS. At discharge from CR, 21% of this group (n=81) were fit for work (vs 35% of patients with a normal occupational prognosis (n=175, P<0.01)). Sick leave before the cardiac event (OR 0.4, 95% CI 0.2–0.6, P<0.01), negative occupational expectations (OR 0.4, 95% CI 0.3–0.7, P<0.01) and depression (OR 0.3, 95% CI 0.1–0.8, P=0.01) reduced the likelihood of achieving work capacity upon discharge. In contrast, higher exercise capacity was positively associated. Conclusion: Patients with a negative occupational prognosis often revealed a reduced physical performance and suffered from a high psychosocial burden. In addition, patients’ occupational expectations were a predictor of work capacity at discharge from CR. Affected patients should be identified at admission to allow for targeted psychosocial care. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 574 KW - cardiac rehabilitation KW - return to work KW - work capacity KW - negative expectation KW - occupational prognosis Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437263 SN - 1866-8364 IS - 574 SP - 301 EP - 308 ER - TY - JOUR A1 - Block, Andrea A1 - Bonaventura, Klaus A1 - Grahn, Patricia A1 - Bestgen, Felix A1 - Wippert, Pia-Maria T1 - Stress management in pre-and postoperative care amongst practitioners and patients in cardiac catheterization laboratory: a study protocol JF - Frontiers in Cardiovascular Medicine N2 - Background: As the number of cardiac diseases continuously increases within the last years in modern society, so does cardiac treatment, especially cardiac catheterization. The procedure of a cardiac catheterization is challenging for both patients and practitioners. Several potential stressors of psychological or physical nature can occur during the procedure. The objective of the study is to develop and implement a stress management intervention for both practitioners and patients that aims to reduce the psychological and physical strain of a cardiac catheterization. Methods: The clinical study (DRKS00026624) includes two randomized controlled intervention trials with parallel groups, for patients with elective cardiac catheterization and practitioners at the catheterization lab, in two clinic sites of the Ernst-von-Bergmann clinic network in Brandenburg, Germany. Both groups received different interventions for stress management. The intervention for patients comprises a psychoeducational video with different stress management technics and additional a standardized medical information about the cardiac catheterization examination. The control condition includes the in hospitals practiced medical patient education before the examination (usual care). Primary and secondary outcomes are measured by physiological parameters and validated questionnaires, the day before (M1) and after (M2) the cardiac catheterization and at a postal follow-up 6 months later (M3). It is expected that people with standardized information and psychoeducation show reduced complications during cardiac catheterization procedures, better pre- and post-operative wellbeing, regeneration, mood and lower stress levels over time. The intervention for practitioners includes a Mindfulness-based stress reduction program (MBSR) over 8 weeks supervised by an experienced MBSR practitioner directly at the clinic site and an operative guideline. It is expected that practitioners with intervention show improved perceived and chronic stress, occupational health, physical and mental function, higher effort-reward balance, regeneration and quality of life. Primary and secondary outcomes are measured by physiological parameters (heart rate variability, saliva cortisol) and validated questionnaires and will be assessed before (M1) and after (M2) the MBSR intervention and at a postal follow-up 6 months later (M3). Physiological biomarkers in practitioners will be assessed before (M1) and after intervention (M2) on two work days and a two days off. Intervention effects in both groups (practitioners and patients) will be evaluated separately using multivariate variance analysis. Discussion: This study evaluates the effectiveness of two stress management intervention programs for patients and practitioners within cardiac catheter laboratory. Study will disclose strains during a cardiac catheterization affecting both patients and practitioners. For practitioners it may contribute to improved working conditions and occupational safety, preservation of earning capacity, avoidance of participation restrictions and loss of performance. In both groups less anxiety, stress and complications before and during the procedures can be expected. The study may add knowledge how to eliminate stressful exposures and to contribute to more (psychological) security, less output losses and exhaustion during work. The evolved stress management guidelines, training manuals and the standardized patient education should be transferred into clinical routines KW - stress management KW - mindfulness-based stress reduction KW - psychoeducation KW - standardized patient information KW - stress intervention KW - distress KW - study protocol KW - cardiac catheterization (CC) Y1 - 2022 U6 - https://doi.org/10.3389/fcvm.2022.830256 SN - 2297-055X VL - 9 SP - 1 EP - 10 PB - Frontiers CY - Lausanne, Schweiz ER - TY - GEN A1 - Wahmkow, Gunnar A1 - Cassel, Michael A1 - Mayer, Frank A1 - Baur, Heiner T1 - Effects of different medial arch support heights on rearfoot kinematics N2 - Background Foot orthoses are usually assumed to be effective by optimizing mechanically dynamic rearfoot configuration. However, the effect from a foot orthosis on kinematics that has been demonstrated scientifically has only been marginal. The aim of this study was to examine the effect of different heights in medial arch-supported foot orthoses on rear foot motion during gait. Methods Nineteen asymptomatic runners (36±11years, 180±5cm, 79±10kg; 41±22km/week) participated in the study. Trials were recorded at 3.1 mph (5 km/h) on a treadmill. Athletes walked barefoot and with 4 different not customized medial arch-supported foot orthoses of various arch heights (N:0 mm, M:30 mm, H:35 mm, E:40mm). Six infrared cameras and the `Oxford Foot Model´ were used to capture motion. The average stride in each condition was calculated from 50 gait cycles per condition. Eversion excursion and internal tibia rotation were analyzed. Descriptive statistics included calculating the mean ± SD and 95% CIs. Group differences by condition were analyzed by one factor (foot orthoses) repeated measures ANOVA (α = 0.05). Results Eversion excursion revealed the lowest values for N and highest for H (B:4.6°±2.2°; 95% CI [3.1;6.2]/N:4.0°±1.7°; [2.9;5.2]/M:5.2°±2.6°; [3.6;6.8]/H:6.2°±3.3°; [4.0;8.5]/E:5.1°±3.5°; [2.8;7.5]) (p>0.05). Range of internal tibia rotation was lowest with orthosis H and highest with E (B:13.3°±3.2°; 95% CI [11.0;15.6]/N:14.5°±7.2°; [9.2;19.6]/M:13.8°±5.0°; [10.8;16.8]/H:12.3°±4.3°; [9.0;15.6]/E:14.9°±5.0°; [11.5;18.3]) (p>0.05). Differences between conditions were small and the intrasubject variation high. Conclusion Our results indicate that different arch support heights have no systematic effect on eversion excursion or the range of internal tibia rotation and therefore might not exert a crucial influence on rear foot alignment during gait. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 348 Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-402934 ER - TY - JOUR A1 - Wahmkow, Gunnar A1 - Cassel, Michael A1 - Mayer, Frank A1 - Baur, Heiner T1 - Effects of different medial arch support heights on rearfoot kinematics JF - PLoS one N2 - Background Foot orthoses are usually assumed to be effective by optimizing mechanically dynamic rearfoot configuration. However, the effect from a foot orthosis on kinematics that has been demonstrated scientifically has only been marginal. The aim of this study was to examine the effect of different heights in medial arch-supported foot orthoses on rear foot motion during gait. Methods Nineteen asymptomatic runners (36±11years, 180±5cm, 79±10kg; 41±22km/week) participated in the study. Trials were recorded at 3.1 mph (5 km/h) on a treadmill. Athletes walked barefoot and with 4 different not customized medial arch-supported foot orthoses of various arch heights (N:0 mm, M:30 mm, H:35 mm, E:40mm). Six infrared cameras and the `Oxford Foot Model´ were used to capture motion. The average stride in each condition was calculated from 50 gait cycles per condition. Eversion excursion and internal tibia rotation were analyzed. Descriptive statistics included calculating the mean ± SD and 95% CIs. Group differences by condition were analyzed by one factor (foot orthoses) repeated measures ANOVA (α = 0.05). Results Eversion excursion revealed the lowest values for N and highest for H (B:4.6°±2.2°; 95% CI [3.1;6.2]/N:4.0°±1.7°; [2.9;5.2]/M:5.2°±2.6°; [3.6;6.8]/H:6.2°±3.3°; [4.0;8.5]/E:5.1°±3.5°; [2.8;7.5]) (p>0.05). Range of internal tibia rotation was lowest with orthosis H and highest with E (B:13.3°±3.2°; 95% CI [11.0;15.6]/N:14.5°±7.2°; [9.2;19.6]/M:13.8°±5.0°; [10.8;16.8]/H:12.3°±4.3°; [9.0;15.6]/E:14.9°±5.0°; [11.5;18.3]) (p>0.05). Differences between conditions were small and the intrasubject variation high. Conclusion Our results indicate that different arch support heights have no systematic effect on eversion excursion or the range of internal tibia rotation and therefore might not exert a crucial influence on rear foot alignment during gait. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0172334 SN - 1932-6203 VL - 12 IS - 3 PB - PLoS CY - Lawrence, Kan. ER - TY - GEN A1 - Cassel, Michael A1 - Müller, Juliane A1 - Moser, Othmar A1 - Strempler, Mares Elaine A1 - Reso, Judith A1 - Mayer, Frank T1 - Orthopedic Injury Profiles in Adolescent Elite Athletes BT - A Retrospective Analysis From a Sports Medicine Department T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Aim: The aim of the study was to identify common orthopedic sports injury profiles in adolescent elite athletes with respect to age, sex, and anthropometrics. Methods: A retrospective data analysis of 718 orthopedic presentations among 381 adolescent elite athletes from 16 different sports to a sports medical department was performed. Recorded data of history and clinical examination included area, cause and structure of acute and overuse injuries. Injury-events were analyzed in the whole cohort and stratified by age (11–14/15–17 years) and sex. Group differences were tested by chi-squared-tests. Logistic regression analysis was applied examining the influence of factors age, sex, and body mass index (BMI) on the outcome variables area and structure (a = 0.05). Results: Higher proportions of injury-events were reported for females (60%) and athletes of the older age group (66%) than males and younger athletes. The most frequently injured area was the lower extremity (47%) followed by the spine (30.5%) and the upper extremity (12.5%). Acute injuries were mainly located at the lower extremity (74.5%), while overuse injuries were predominantly observed at the lower extremity (41%) as well as the spine (36.5%). Joints (34%), muscles (22%), and tendons (21.5%) were found to be the most often affected structures. The injured structures were different between the age groups (p = 0.022), with the older age group presenting three times more frequent with ligament pathology events (5.5%/2%) and less frequent with bony problems (11%/20.5%) than athletes of the younger age group. The injured area differed between the sexes (p = 0.005), with males having fewer spine injury-events (25.5%/34%) but more upper extremity injuries (18%/9%) than females. Regression analysis showed statistically significant influence for BMI (p = 0.002) and age (p = 0.015) on structure, whereas the area was significantly influenced by sex (p = 0.005). Conclusion: Events of soft-tissue overuse injuries are the most common reasons resulting in orthopedic presentations of adolescent elite athletes. Mostly, the lower extremity and the spine are affected, while sex and age characteristics on affected area and structure must be considered. Therefore, prevention strategies addressing the injury-event profiles should already be implemented in early adolescence taking age, sex as well as injury entity into account. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 559 KW - overuse injuries KW - epidemiology KW - complaints KW - symptoms KW - risk factors KW - sports Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-434953 SN - 1866-8364 IS - 559 ER - TY - JOUR A1 - Cassel, Michael A1 - Müller, Juliane A1 - Moser, Othmar A1 - Strempler, Mares Elaine A1 - Reso, Judith A1 - Mayer, Frank T1 - Orthopedic Injury Profiles in Adolescent Elite Athletes BT - A Retrospective Analysis From a Sports Medicine Department JF - Frontiers in Physiology N2 - Aim: The aim of the study was to identify common orthopedic sports injury profiles in adolescent elite athletes with respect to age, sex, and anthropometrics. Methods: A retrospective data analysis of 718 orthopedic presentations among 381 adolescent elite athletes from 16 different sports to a sports medical department was performed. Recorded data of history and clinical examination included area, cause and structure of acute and overuse injuries. Injury-events were analyzed in the whole cohort and stratified by age (11–14/15–17 years) and sex. Group differences were tested by chi-squared-tests. Logistic regression analysis was applied examining the influence of factors age, sex, and body mass index (BMI) on the outcome variables area and structure (a = 0.05). Results: Higher proportions of injury-events were reported for females (60%) and athletes of the older age group (66%) than males and younger athletes. The most frequently injured area was the lower extremity (47%) followed by the spine (30.5%) and the upper extremity (12.5%). Acute injuries were mainly located at the lower extremity (74.5%), while overuse injuries were predominantly observed at the lower extremity (41%) as well as the spine (36.5%). Joints (34%), muscles (22%), and tendons (21.5%) were found to be the most often affected structures. The injured structures were different between the age groups (p = 0.022), with the older age group presenting three times more frequent with ligament pathology events (5.5%/2%) and less frequent with bony problems (11%/20.5%) than athletes of the younger age group. The injured area differed between the sexes (p = 0.005), with males having fewer spine injury-events (25.5%/34%) but more upper extremity injuries (18%/9%) than females. Regression analysis showed statistically significant influence for BMI (p = 0.002) and age (p = 0.015) on structure, whereas the area was significantly influenced by sex (p = 0.005). Conclusion: Events of soft-tissue overuse injuries are the most common reasons resulting in orthopedic presentations of adolescent elite athletes. Mostly, the lower extremity and the spine are affected, while sex and age characteristics on affected area and structure must be considered. Therefore, prevention strategies addressing the injury-event profiles should already be implemented in early adolescence taking age, sex as well as injury entity into account. KW - overuse injuries KW - epidemiology KW - complaints KW - symptoms KW - risk factors KW - sports Y1 - 2019 U6 - https://doi.org/10.3389/fphys.2019.00544 SN - 1664-042X VL - 10 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Müller, Steffen A1 - Stoll, Josefine A1 - Cassel, Michael A1 - Mayer, Frank T1 - Trunk Muscle Activity during Drop Jump Performance in Adolescent Athletes with Back Pain N2 - In the context of back pain, great emphasis has been placed on the importance of trunk stability, especially in situations requiring compensation of repetitive, intense loading induced during high-performance activities, e.g., jumping or landing. This study aims to evaluate trunk muscle activity during drop jump in adolescent athletes with back pain (BP) compared to athletes without back pain (NBP). Eleven adolescent athletes suffering back pain (BP: m/f: n = 4/7; 15.9 ± 1.3 y; 176 ± 11 cm; 68 ± 11 kg; 12.4 ± 10.5 h/we training) and 11 matched athletes without back pain (NBP: m/f: n = 4/7; 15.5 ± 1.3 y; 174 ± 7 cm; 67 ± 8 kg; 14.9 ± 9.5 h/we training) were evaluated. Subjects conducted 3 drop jumps onto a force plate (ground reaction force). Bilateral 12-lead SEMG (surface Electromyography) was applied to assess trunk muscle activity. Ground contact time [ms], maximum vertical jump force [N], jump time [ms] and the jump performance index [m/s] were calculated for drop jumps. SEMG amplitudes (RMS: root mean square [%]) for all 12 single muscles were normalized to MIVC (maximum isometric voluntary contraction) and analyzed in 4 time windows (100 ms pre- and 200 ms post-initial ground contact, 100 ms pre- and 200 ms post-landing) as outcome variables. In addition, muscles were grouped and analyzed in ventral and dorsal muscles, as well as straight and transverse trunk muscles. Drop jump ground reaction force variables did not differ between NBP and BP (p > 0.05). Mm obliquus externus and internus abdominis presented higher SEMG amplitudes (1.3–1.9-fold) for BP (p < 0.05). Mm rectus abdominis, erector spinae thoracic/lumbar and latissimus dorsi did not differ (p > 0.05). The muscle group analysis over the whole jumping cycle showed statistically significantly higher SEMG amplitudes for BP in the ventral (p = 0.031) and transverse muscles (p = 0.020) compared to NBP. Higher activity of transverse, but not straight, trunk muscles might indicate a specific compensation strategy to support trunk stability in athletes with back pain during drop jumps. Therefore, exercises favoring the transverse trunk muscles could be recommended for back pain treatment. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 319 KW - SEMG-pattern KW - back pain KW - drop jump KW - neuromuscular KW - performance KW - pre-activity KW - trunk KW - young athletes Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-395261 ER - TY - JOUR A1 - Müller, Steffen A1 - Stoll, Josefine A1 - Cassel, Michael A1 - Mayer, Frank T1 - Trunk Muscle Activity during Drop Jump Performance in Adolescent Athletes with Back Pain JF - Frontiers in physiology N2 - In the context of back pain, great emphasis has been placed on the importance of trunk stability, especially in situations requiring compensation of repetitive, intense loading induced during high-performance activities, e.g., jumping or landing. This study aims to evaluate trunk muscle activity during drop jump in adolescent athletes with back pain (BP) compared to athletes without back pain (NBP). Eleven adolescent athletes suffering back pain (BP: m/f: n = 4/7; 15.9 ± 1.3 y; 176 ± 11 cm; 68 ± 11 kg; 12.4 ± 10.5 h/we training) and 11 matched athletes without back pain (NBP: m/f: n = 4/7; 15.5 ± 1.3 y; 174 ± 7 cm; 67 ± 8 kg; 14.9 ± 9.5 h/we training) were evaluated. Subjects conducted 3 drop jumps onto a force plate (ground reaction force). Bilateral 12-lead SEMG (surface Electromyography) was applied to assess trunk muscle activity. Ground contact time [ms], maximum vertical jump force [N], jump time [ms] and the jump performance index [m/s] were calculated for drop jumps. SEMG amplitudes (RMS: root mean square [%]) for all 12 single muscles were normalized to MIVC (maximum isometric voluntary contraction) and analyzed in 4 time windows (100 ms pre- and 200 ms post-initial ground contact, 100 ms pre- and 200 ms post-landing) as outcome variables. In addition, muscles were grouped and analyzed in ventral and dorsal muscles, as well as straight and transverse trunk muscles. Drop jump ground reaction force variables did not differ between NBP and BP (p > 0.05). Mm obliquus externus and internus abdominis presented higher SEMG amplitudes (1.3–1.9-fold) for BP (p < 0.05). Mm rectus abdominis, erector spinae thoracic/lumbar and latissimus dorsi did not differ (p > 0.05). The muscle group analysis over the whole jumping cycle showed statistically significantly higher SEMG amplitudes for BP in the ventral (p = 0.031) and transverse muscles (p = 0.020) compared to NBP. Higher activity of transverse, but not straight, trunk muscles might indicate a specific compensation strategy to support trunk stability in athletes with back pain during drop jumps. Therefore, exercises favoring the transverse trunk muscles could be recommended for back pain treatment. KW - SEMG-pattern KW - back pain KW - pre-activity KW - drop jump KW - neuromuscular KW - trunk KW - performance KW - young athletes Y1 - 2017 U6 - https://doi.org/10.3389/fphys.2017.00274 SN - 1664-042X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Fliesser, Michael T1 - National doping prevention guidelines : Intent, efficacy and lessons learned BT - Substance abuse treatment, prevention, and policy N2 - Background Doping presents a potential health risk for young athletes. Prevention programs are intended to prevent doping by educating athletes about banned substances. However, such programs have their limitations in practice. This led Germany to introduce the National Doping Prevention Plan (NDPP), in hopes of ameliorating the situation among young elite athletes. Two studies examined 1) the degree to which the NDPP led to improved prevention efforts in elite sport schools, and 2) the extent to which newly developed prevention activities of the national anti-doping agency (NADA) based on the NDPP have improved knowledge among young athletes within elite sports schools. Methods The first objective was investigated in a longitudinal study (Study I: t0 = baseline, t1 = follow-up 4 years after NDPP introduction) with N = 22 teachers engaged in doping prevention in elite sports schools. The second objective was evaluated in a cross-sectional comparison study (Study II) in N = 213 elite sports school students (54.5 % male, 45.5 % female, age M = 16.7 ± 1.3 years (all students had received the improved NDDP measure in school; one student group had received additionally NADA anti-doping activities and a control group did not). Descriptive statistics were calculated, followed by McNemar tests, Wilcoxon tests and Analysis of Covariance (ANCOVA). Results Results indicate that 4 years after the introduction of the NDPP there have been limited structural changes with regard to the frequency, type, and scope of doping prevention in elite sport schools. On the other hand, in study II, elite sport school students who received further NADA anti-doping activities performed better on an anti-doping knowledge test than students who did not take part (F(1, 207) = 33.99, p <0.001), although this difference was small. Conclusion The integration of doping-prevention in elite sport schools as part of the NDPP was only partially successful. The results of the evaluation indicate that the introduction of the NDPP has contributed more to a change in the content of doping prevention activities than to a structural transformation in anti-doping education in elite sport schools. Moreover, while students who did receive additional education in the form of the NDPP“booster sessions” had significantly more knowledge about doping than students who did not receive such education, this difference was only small and may not translate to actual behavior. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 309 KW - Anti-doping guideline KW - Anti-doping program KW - Doping KW - Elite sports schools Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-100406 ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Fliesser, Michael T1 - National doping prevention guidelines : Intent, efficacy and lessons learned BT - A 4-year evaluation JF - Substance abuse treatment, prevention, and policy N2 - Background Doping presents a potential health risk for young athletes. Prevention programs are intended to prevent doping by educating athletes about banned substances. However, such programs have their limitations in practice. This led Germany to introduce the National Doping Prevention Plan (NDPP), in hopes of ameliorating the situation among young elite athletes. Two studies examined 1) the degree to which the NDPP led to improved prevention efforts in elite sport schools, and 2) the extent to which newly developed prevention activities of the national anti-doping agency (NADA) based on the NDPP have improved knowledge among young athletes within elite sports schools. Methods The first objective was investigated in a longitudinal study (Study I: t0 = baseline, t1 = follow-up 4 years after NDPP introduction) with N = 22 teachers engaged in doping prevention in elite sports schools. The second objective was evaluated in a cross-sectional comparison study (Study II) in N = 213 elite sports school students (54.5 % male, 45.5 % female, age M = 16.7 ± 1.3 years (all students had received the improved NDDP measure in school; one student group had received additionally NADA anti-doping activities and a control group did not). Descriptive statistics were calculated, followed by McNemar tests, Wilcoxon tests and Analysis of Covariance (ANCOVA). Results Results indicate that 4 years after the introduction of the NDPP there have been limited structural changes with regard to the frequency, type, and scope of doping prevention in elite sport schools. On the other hand, in study II, elite sport school students who received further NADA anti-doping activities performed better on an anti-doping knowledge test than students who did not take part (F(1, 207) = 33.99, p <0.001), although this difference was small. Conclusion The integration of doping-prevention in elite sport schools as part of the NDPP was only partially successful. The results of the evaluation indicate that the introduction of the NDPP has contributed more to a change in the content of doping prevention activities than to a structural transformation in anti-doping education in elite sport schools. Moreover, while students who did receive additional education in the form of the NDPP“booster sessions” had significantly more knowledge about doping than students who did not receive such education, this difference was only small and may not translate to actual behavior. KW - Doping KW - Anti-doping program KW - Anti-doping guideline KW - Elite sports schools Y1 - 2016 U6 - https://doi.org/10.1186/s13011-016-0079-9 SN - 1747-597X VL - 11 PB - BioMed Central CY - London ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Rector, Michael V. A1 - Kuhn, Gisela A1 - Wuertz-Kozak, Karin T1 - Stress and Alterations in Bones BT - An Interdisciplinary Perspective N2 - Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 323 KW - biomechanics KW - bone–brain–nervous system interactions KW - endocrine pathways KW - exercise KW - osteoporosis Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-395866 ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Rector, Michael V. A1 - Kuhn, Gisela A1 - Wuertz-Kozak, Karin T1 - Stress and Alterations in Bones BT - An Interdisciplinary Perspective JF - Frontiers in endocrinology N2 - Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions. KW - biomechanics KW - bone–brain–nervous system interactions KW - endocrine pathways KW - osteoporosis KW - exercise Y1 - 2017 U6 - https://doi.org/10.3389/fendo.2017.00096 SN - 1664-2392 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Fliesser, Michael A1 - Krause, Matthias T1 - Risk and protective factors in the clinical rehabilitation of chronic back pain N2 - Objectives: Chronic back pain (CBP) can lead to disability and burden. In addition to its medical causes, its development is influenced by psychosocial risk factors, the so-called flag factors, which are categorized and integrated into many treatment guidelines. Currently, most studies investigate single flag factors, which limit the estimation of individual factor significance in the development of chronic pain. Furthermore, factors concerning patients’ lifestyle, biography and treatment history are often neglected. Therefore, the objectives of the present study are to identify commonly neglected factors of CBP and integrate them into an analysis model comparing their significance with established flag factors. Methods: A total of 24 patients and therapists were cross-sectionally interviewed to identify commonly neglected factors of CBP. Subsequently, the impact of these factors was surveyed in a longitudinal study. In two rehabilitation clinics, CBP patients (n = 145) were examined before and 6 months after a 3-week inpatient rehabilitation. Outcome variables, chronification factor pain experience (CF-PE) and chronification factor disability (CF-D), were ascertained with confirmatory factor analysis (CFA) of standardized questionnaires. Predictors were evaluated using stepwise calculations of simple and multiple regression models. Results: Through interviews, medical history, iatrogenic factors, poor compliance, critical life events (LEs), social support (SS) type and effort–reward were identified as commonly neglected factors. However, only the final three held significance in comparison to established factors such as depression and pain-related cognitions. Longitudinally, lifestyle factors found to influence future pain were initial pain, physically demanding work, nicotine consumption, gender and rehabilitation clinic. LEs were unexpectedly found to be a strong predictor of future pain, as were the protective factors, reward at work and perceived SS. Discussion: These findings shed insight regarding often overlooked factors in the development of CBP, suggesting that more detailed operationalization and superordinate frameworks would be beneficial to further research. Conclusion: In particular, LEs should be taken into account in future research. Protective factors should be integrated in therapeutic settings. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 345 KW - yellow flags KW - life events KW - clinical pain research Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-402201 ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Fliesser, Michael A1 - Krause, Matthias T1 - Risk and protective factors in the clinical rehabilitation of chronic back pain JF - Journal of pain research N2 - Objectives: Chronic back pain (CBP) can lead to disability and burden. In addition to its medical causes, its development is influenced by psychosocial risk factors, the so-called flag factors, which are categorized and integrated into many treatment guidelines. Currently, most studies investigate single flag factors, which limit the estimation of individual factor significance in the development of chronic pain. Furthermore, factors concerning patients’ lifestyle, biography and treatment history are often neglected. Therefore, the objectives of the present study are to identify commonly neglected factors of CBP and integrate them into an analysis model comparing their significance with established flag factors. Methods: A total of 24 patients and therapists were cross-sectionally interviewed to identify commonly neglected factors of CBP. Subsequently, the impact of these factors was surveyed in a longitudinal study. In two rehabilitation clinics, CBP patients (n = 145) were examined before and 6 months after a 3-week inpatient rehabilitation. Outcome variables, chronification factor pain experience (CF-PE) and chronification factor disability (CF-D), were ascertained with confirmatory factor analysis (CFA) of standardized questionnaires. Predictors were evaluated using stepwise calculations of simple and multiple regression models. Results: Through interviews, medical history, iatrogenic factors, poor compliance, critical life events (LEs), social support (SS) type and effort–reward were identified as commonly neglected factors. However, only the final three held significance in comparison to established factors such as depression and pain-related cognitions. Longitudinally, lifestyle factors found to influence future pain were initial pain, physically demanding work, nicotine consumption, gender and rehabilitation clinic. LEs were unexpectedly found to be a strong predictor of future pain, as were the protective factors, reward at work and perceived SS. Discussion: These findings shed insight regarding often overlooked factors in the development of CBP, suggesting that more detailed operationalization and superordinate frameworks would be beneficial to further research. Conclusion: In particular, LEs should be taken into account in future research. Protective factors should be integrated in therapeutic settings. KW - yellow flags KW - life events KW - clinical pain research Y1 - 2017 U6 - https://doi.org/10.2147/JPR.S134976 SN - 1178-7090 VL - 10 SP - 1569 EP - 1579 PB - Dove Medical Press CY - Albany, Auckland ER - TY - GEN A1 - Felisatti, Arianna A1 - Laubrock, Jochen A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Commentary BT - A mental number line in human newborns T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 620 KW - spatial-numerical associations KW - SNARC KW - mental number line (MNL) KW - spatial frequency (SF) KW - temporal frequency KW - hemispheric asymmetry KW - newborns KW - embodied cognition Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-460413 SN - 1866-8364 IS - 620 ER - TY - GEN A1 - Boll-Avetisyan, Natalie A1 - Bhatara, Anjali A1 - Höhle, Barbara T1 - Processing of rhythm in speech and music in adult dyslexia T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Recent studies have suggested that musical rhythm perception ability can affect the phonological system. The most prevalent causal account for developmental dyslexia is the phonological deficit hypothesis. As rhythm is a subpart of phonology, we hypothesized that reading deficits in dyslexia are associated with rhythm processing in speech and in music. In a rhythmic grouping task, adults with diagnosed dyslexia and age-matched controls listened to speech streams with syllables alternating in intensity, duration, or neither, and indicated whether they perceived a strong-weak or weak-strong rhythm pattern. Additionally, their reading and musical rhythm abilities were measured. Results showed that adults with dyslexia had lower musical rhythm abilities than adults without dyslexia. Moreover, lower musical rhythm ability was associated with lower reading ability in dyslexia. However, speech grouping by adults with dyslexia was not impaired when musical rhythm perception ability was controlled: like adults without dyslexia, they showed consistent preferences. However, rhythmic grouping was predicted by musical rhythm perception ability, irrespective of dyslexia. The results suggest associations among musical rhythm perception ability, speech rhythm perception, and reading ability. This highlights the importance of considering individual variability to better understand dyslexia and raises the possibility that musical rhythm perception ability is a key to phonological and reading acquisition. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 630 KW - developmental dyslexia KW - Iambic/Trochaic Law KW - rhythmic grouping KW - musicality KW - speech perception KW - rhythm perception Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469781 SN - 1866-8364 IS - 630 ER - TY - GEN A1 - Ciaccio, Laura Anna A1 - Burchert, Frank A1 - Semenza, Carlo T1 - Derivational morphology in agrammatic aphasia BT - a comparison between prefixed and suffixed words T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Although a relatively large number of studies on acquired language impairments have tested the case of derivational morphology, none of these have specifically investigated whether there are differences in how prefixed and suffixed derived words are impaired. Based on linguistic and psycholinguistic considerations on prefixed and suffixed derived words, differences in how these two types of derivations are processed, and consequently impaired, are predicted. In the present study, we investigated the errors produced in reading aloud simple, prefixed, and suffixed words by three German individuals with agrammatic aphasia (NN, LG, SA). We found that, while NN and LG produced similar numbers of errors with prefixed and suffixed words, SA showed a selective impairment for prefixed words. Furthermore, NN and SA produced more errors specifically involving the affix with prefixed words than with suffixed words. We discuss our findings in terms of relative position of stem and affix in prefixed and suffixed words, as well as in terms of specific properties of prefixes and suffixes. KW - Broca’s aphasia KW - morphological decomposition KW - morphological errors KW - derivation KW - prefixes Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473995 SN - 1866-8364 IS - 648 ER - TY - GEN A1 - Zoch-Lesniak, Beate A1 - Dobberke, Jeanette A1 - Schlitt, Axel A1 - Bongarth, Christa A1 - Glatz, Johannes A1 - Spörl-Dönch, Sieglinde A1 - Koran, Iryna A1 - Völler, Heinz A1 - Salzwedel, Annett T1 - Performance Measures for Short-Term Cardiac Rehabilitation in Patients of Working Age BT - Results of the Prospective Observational Multicenter Registry OutCaRe T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Objective: To determine immediate performance measures for short-term, multicomponent cardiac rehabilitation (CR) in clinical routine in patients of working age, taking into account cardiovascular risk factors, physical performance, social medicine, and subjective health parameters and to explore the underlying dimensionality. Design: Prospective observational multicenter register study in 12 rehabilitation centers throughout Germany. Setting: Comprehensive 3-week CR. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 646 KW - Cardiac rehabilitation KW - Outcome measures KW - Cardiovascular diseases Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473922 SN - 1866-8364 ER - TY - GEN A1 - Eichler, Sarah A1 - Völler, Heinz A1 - Reibis, Rona Katharina A1 - Wegscheider, Karl A1 - Butter, Christian A1 - Harnath, Axel A1 - Salzwedel, Annett T1 - Geriatric or cardiac rehabilitation? BT - Predictors of treatment pathways in advanced age patients after transcatheter aortic valve implantation T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background Aim of the study was to find predictors of allocating patients after transcatheter aortic valve implantation (TAVI) to geriatric (GR) or cardiac rehabilitation (CR) and describe this new patient group based on a differentiated characterization. Methods From 10/2013 to 07/2015, 344 patients with an elective TAVI were consecutively enrolled in this prospective multicentric cohort study. Before intervention, sociodemographic parameters, echocardiographic data, comorbidities, 6-min walk distance (6MWD), quality of life and frailty (score indexing activities of daily living [ADL], cognition, nutrition and mobility) were documented. Out of these, predictors for assignment to CR or GR after TAVI were identified using a multivariable regression model. Results After TAVI, 249 patients (80.7 ± 5.1 years, 59.0% female) underwent CR (n = 198) or GR (n = 51). GR patients were older, less physically active and more often had a level of care, peripheral artery disease as well as a lower left ventricular ejection fraction. The groups also varied in 6MWD. Furthermore, individual components of frailty revealed prognostic impact: higher values in instrumental ADL reduced the probability for referral to GR (OR:0.49, p <  0.001), while an impaired mobility was positively associated with referral to GR (OR:3.97, p = 0.046). Clinical parameters like stroke (OR:0.19 of GR, p = 0.038) and the EuroSCORE (OR:1.04 of GR, p = 0.026) were also predictive. Conclusion Advanced age patients after TAVI referred to CR or GR differ in several parameters and seem to be different patient groups with specific needs, e.g. regarding activities of daily living and mobility. Thus, our data prove the eligibility of both CR and GR settings. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 647 KW - TAVI KW - Treatment pathways KW - Frailty KW - Geriatric rehabilitation Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473958 SN - 1866-8364 ER - TY - GEN A1 - Brand, Ralf A1 - Ulrich, Lukas T1 - I Can See It in Your Face. BT - Affective Valuation of Exercise in More or Less Physically Active Individuals T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - The purpose of this study was to illustrate that people’s affective valuation of exercise can be identified in their faces. The study was conducted with a software for automatic facial expression analysis and it involved testing the hypothesis that positive or negative affective valuation occurs spontaneously when people are reminded of exercise. We created a task similar to an emotional Stroop task, in which participants responded to exercise-related and control stimuli with a positive or negative facial expression (smile or frown) depending on whether the photo was presented upright or tilted. We further asked participants how much time they would normally spend for physical exercise, because we assumed that the affective valuation of those who exercise more would be more positive. Based on the data of 86 participants, regression analysis revealed that those who reported less exercise and a more negative reflective evaluation of exercise initiated negative facial expressions on exercise-related stimuli significantly faster than those who reported exercising more often. No significant effect was observed for smile responses. We suspect that responding with a smile to exercise-related stimuli was the congruent response for the majority of our participants, so that for them no Stroop interference occurred in the exercise-related condition. This study suggests that immediate negative affective reactions to exercise-related stimuli result from a postconscious automatic process and can be detected in the study participants’ faces. It furthermore illustrates how methodological paradigms from social–cognition research (here: the emotional Stroop paradigm) can be adapted to collect and analyze biometric data for the investigation of exercisers’ and non-exercisers’ automatic valuations of exercise. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 597 KW - motivation KW - exercise KW - emotion KW - automatic facial expression analysis KW - Stroop effect Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-444481 SN - 1866-8364 IS - 597 ER - TY - GEN A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Rabe, Sophie A1 - Mueller, Steffen A1 - Mayer, Frank A1 - Wochatz, Monique A1 - Hadzic, Miralem A1 - John, Michael A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement BT - Randomized Controlled Trial T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare. Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare. Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints. Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note. Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 589 KW - telerehabilitation KW - home-based KW - total hip replacement KW - total knee replacement KW - exercise therapy KW - aftercare KW - rehabilitation Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440965 SN - 1866-8364 IS - 589 ER - TY - JOUR A1 - Yang, Jingdan A1 - Kim, Jae-Hyun A1 - Tuomainen, Outi A1 - Rattanasone, Nan Xu T1 - Bilingual Mandarin-English preschoolers’ spoken narrative skills and contributing factors BT - A remote online story-retell study JF - Frontiers in Psyhology N2 - This study examined the spoken narrative skills of a group of bilingual Mandarin–English speaking 3–6-year-olds (N = 25) in Australia, using a remote online story-retell task. Bilingual preschoolers are an understudied population, especially those who are speaking typologically distinct languages such as Mandarin and English which have fewer structural overlaps compared to language pairs that are typologically closer, reducing cross-linguistic positive transfer. We examined these preschoolers’ spoken narrative skills as measured by macrostructures (the global organization of a story) and microstructures (linguistic structures, e.g., total number of utterances, nouns, verbs, phrases, and modifiers) across and within each language, and how various factors such as age and language experiences contribute to individual variability. The results indicate that our bilingual preschoolers acquired spoken narrative skills similarly across their two languages, i.e., showing similar patterns of productivity for macrostructure and microstructure elements in both of their two languages. While chronological age was positively correlated with macrostructures in both languages (showing developmental effects), there were no significant correlations between measures of language experiences and the measures of spoken narrative skills (no effects for language input/output). The findings suggest that although these preschoolers acquire two typologically diverse languages in different learning environments, Mandarin at home with highly educated parents, and English at preschool, they displayed similar levels of oral narrative skills as far as these macro−/micro-structure measures are concerned. This study provides further evidence for the feasibility of remote online assessment of preschoolers’ narrative skills. KW - narrative skills KW - Mandarin-English bilinguals KW - preschoolers KW - macrostructure KW - microstructure Y1 - 2022 U6 - https://doi.org/10.3389/fpsyg.2022.797602 SN - 1664-1078 VL - 13 PB - Frontiers Media SA CY - Lausanne, Schweiz ER - TY - JOUR A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Reibis, Rona A1 - Nothroff, Jörg A1 - Harnath, Axel A1 - Schikora, Martin A1 - Butter, Christian A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - Multicomponent cardiac rehabilitation in patients after transcatheter aortic valve implantation BT - predictors of functional and psychocognitive recovery JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Background: In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods: From October 2013 to July 2015, patients with elective transcatheter aortic valve implantation and a subsequent inpatient cardiac rehabilitation were enrolled in the prospective cohort multicentre study. Frailty-Index (including cognition, nutrition, autonomy and mobility), Short Form-12 (SF-12), six-minute walk distance (6MWD) and maximum work load in bicycle ergometry were performed at admission and discharge of cardiac rehabilitation. The relation between patient characteristics and improvements in 6MWD, maximum work load or SF-12 scales were studied univariately and multivariately using regression models. Results: One hundred and thirty-six patients (80.6 +/- 5.0 years, 47.8% male) were enrolled. 6MWD and maximum work load increased by 56.3 +/- 65.3 m (p < 0.001) and 8.0 +/- 14.9 watts (p < 0.001), respectively. An improvement in SF-12 (physical 2.5 +/- 8.7, p = 0.001, mental 3.4 +/- 10.2, p = 0.003) could be observed. In multivariate analysis, age and higher education were significantly associated with a reduced 6MWD, whereas cognition and obesity showed a positive predictive value. Higher cognition, nutrition and autonomy positively influenced the physical scale of SF-12. Additionally, the baseline values of SF-12 had an inverse impact on the change during cardiac rehabilitation. Conclusions: Cardiac rehabilitation can improve functional capacity as well as quality of life and reduce frailty in patients after transcatheter aortic valve implantation. An individually tailored therapy with special consideration of cognition and nutrition is needed to maintain autonomy and empower octogenarians in coping with challenges of everyday life. KW - Cardiac rehabilitation KW - TAVI KW - frailty KW - quality of life KW - exercise capacity Y1 - 2017 U6 - https://doi.org/10.1177/2047487316679527 SN - 2047-4873 SN - 2047-4881 VL - 24 IS - 3 SP - 257 EP - 264 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Krupkova, Olga A1 - Sadowska, Aleksandra A1 - Kameda, Takuya A1 - Hitzl, Wolfgang A1 - Hausmann, Oliver Nic A1 - Klasen, Jürgen A1 - Wuertz-Kozak, Karin T1 - p38 MaPK Facilitates crosstalk Between endoplasmic reticulum stress and IL-6 release in the intervertebral Disc JF - Frontiers in Immunology N2 - Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as a possible modulator of inflammation in age-related disorders. In addition, ER stress has been associated with the microenvironment of degenerated IVDs. Therefore, the aim of this study was to analyze the effects of ER stress on inflammatory responses in degenerated human IVDs and associated molecular mechanisms. Gene expression of ER stress marker GRP78 and pro-inflammatory cytokines IL-6, IL-8, IL-1 beta, and TNF-alpha was analyzed in human surgical IVD samples (n = 51, Pfirrmann grade 2-5). The expression of GRP78 positively correlated with the degeneration grade in lumbar IVDs and IL-6, but not with IL-1 beta and TNF-alpha. Another set of human surgical IVD samples (n = 25) was used to prepare primary cell cultures. ER stress inducer thapsigargin (Tg, 100 and 500 nM) activated gene and protein expression of IL-6 and induced phosphorylation of p38 MAPK. Both inhibition of p38 MAPK by SB203580 (10 mu M) and knockdown of ER stress effector CCAAT-enhancer-binding protein homologous protein (CHOP) reduced gene and protein expression of IL-6 in Tg-treated cells. Furthermore, the effects of an inflammatory microenvironment on ER stress were tested. TNF-alpha (5 and 10 ng/mL) did not activate ER stress, while IL-1 beta (5 and 10 ng/mL) activated gene and protein expression of GRP78, but did not influence [Ca2+](i) flux and expression of CHOP, indicating that pro-inflammatory cytokines alone may not induce ER stress in vivo. This study showed that IL-6 release in the IVD can be initiated following ER stress and that ER stress mediates IL-6 release through p38 MAPK and CHOP. Therapeutic targeting of ER stress response may reduce the consequences of the harsh microenvironment in degenerated IVD. KW - intervertebral disc KW - inflammation KW - endoplasmic reticulum stress KW - p38 MAPK KW - CHOP KW - GADD153 KW - GRP78 KW - IL-6 Y1 - 2018 U6 - https://doi.org/10.3389/fimmu.2018.01706 SN - 1664-3224 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Strotseva-Feinschmidt, Anna A1 - Schipke, Christine S. A1 - Gunter, Thomas C. A1 - Brauer, Jens A1 - Friederici, Angela D. T1 - Young children’s sentence comprehension T1 - Neural correlates of syntax-semantic competition JF - Brain and cognition : a journal of experimental and clinical research N2 - Sentence comprehension requires the assignment of thematic relations between the verb and its noun arguments in order to determine who is doing what to whom. In some languages, such as English, word order is the primary syntactic cue. In other languages, such as German, case-marking is additionally used to assign thematic roles. During development children have to acquire the thematic relevance of these syntactic cues and weigh them against semantic cues. Here we investigated the processing of syntactic cues and semantic cues in 2- and 3-year-old children by analyzing their behavioral and neurophysiological responses. Case-marked subject-first and object-first sentences (syntactic cue) including animate and inanimate nouns (semantic cue) were presented auditorily. The semantic animacy cue either conflicted with or supported the thematic roles assigned by syntactic case-marking. In contrast to adults, for whom semantics did not interfere with case-marking, children attended to both syntactic and to semantic cues with a stronger reliance on semantic cues in early development. Children’s event-related brain potentials indicated sensitivity to syntactic information but increased processing costs when case-marking and animacy assigned conflicting thematic roles. These results demonstrate an early developmental sensitivity and ongoing shift towards the use of syntactic cues during sentence comprehension. Y1 - 2018 U6 - https://doi.org/10.1016/j.bandc.2018.09.003 SN - 0278-2626 SN - 1090-2147 VL - 134 SP - 110 EP - 121 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - García, Rowena A1 - Roeser, Jens A1 - Höhle, Barbara T1 - Thematic role assignment in the L1 acquisition of Tagalog T1 - Use of word order and morphosyntactic markers JF - Language acquisition : a journal of developmental linguistics N2 - It is a common finding across languages that young children have problems in understanding patient-initial sentences. We used Tagalog, a verb-initial language with a reliable voice-marking system and highly frequent patient voice constructions, to test the predictions of several accounts that have been proposed to explain this difficulty: the frequency account, the Competition Model, and the incremental processing account. Study 1 presents an analysis of Tagalog child-directed speech, which showed that the dominant argument order is agent-before-patient and that morphosyntactic markers are highly valid cues to thematic role assignment. In Study 2, we used a combined self-paced listening and picture verification task to test how Tagalog-speaking adults and 5- and 7-year-old children process reversible transitive sentences. Results showed that adults performed well in all conditions, while children’s accuracy and listening times for the first noun phrase indicated more difficulty in interpreting patient-initial sentences in the agent voice compared to the patient voice. The patient voice advantage is partly explained by both the frequency account and incremental processing account. Y1 - 2018 U6 - https://doi.org/10.1080/10489223.2018.1525613 SN - 1048-9223 SN - 1532-7817 VL - 26 IS - 3 SP - 235 EP - 261 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Moraske, Svenja A1 - Penrose, Anna A1 - Wyschkon, Anne A1 - Kohn, Juliane A1 - Rauscher, Larissa A1 - von Aster, Michael G. A1 - Esser, Günter T1 - Prävention von Rechenstörungen T1 - Prevention of Dyscalculia BT - Kurz- und mittelfristige Effekte einer Förderung der mathematischen Kompetenzen bei Risikokindern im Vorschulalter BT - Short-Term and Intermediate Effects of Stimulating Numerical Competencies for Children at Risk in Preschool JF - Kindheit und Entwicklung N2 - Ziel ist die Überprüfung der kurz- und mittelfristigen Wirksamkeit einer vorschulischen Förderung des Mengen- und Zahlenverständnisses bei Kindern mit einem Risiko für die Entwicklung einer Rechenstörung. Es wurden 32 Risikokinder mit einer Kombination aus den Förderprogrammen Mathematik im Vorschulalter und Mengen, zählen, Zahlen im letzten Kindergartenjahr von den Erzieherinnen trainiert und mit 38 untrainierten Risikokindern verglichen. Hinsichtlich der kurzfristigen Wirksamkeit zeigten sich positive Trainingseffekte auf die numerischen Leistungen im letzten Kindergartenjahr. Es ließen sich keine signifikanten mittelfristigen Trainingseffekte auf die Rechenleistungen im zweiten Halbjahr der 1. Klasse finden. Das eingesetzte vorschulische Präventionsprogramm leistete danach einen wichtigen Beitrag zur kurzfristigen Verbesserung der mathematischen Basiskompetenzen. N2 - A slew of studies has shown that training programs teaching numerical competencies have positive short-term effects on mathematical performance. The results for the intermediate effects are not consistent and there are only a few studies on this issue. The aim of this investigation was to evaluate the short-term and intermediate effects of a preschool training program stimulating numerical competencies for children at risk of developing dyscalculia (<= 10th percentile). During the last kindergarten year, 32 children at risk were trained with a combination of the intervention Mathematik im Vorschulalter and Mengen, zahlen, Zahlen by their kindergarten teachers, who were trained and supervised. Contents of the preschool training were: counting, number knowledge up to 10, comprehension of quantity concept, visual differentiation, spatial ability, simple arithmetic operation, handling of symbols, realizing abstract-logical correlations, and identifying cause-effect relations. The training lasted 11 weeks and took place twice a week (session duration = 30-40 min). Children who participated in at least 50% of the sessions were included. The control group consisted of 38 untrained children at risk. For measuring numerical competencies in kindergarten, a subtest of the instrument Basisdiagnostik Umschriebener Entwicklungsstorungen im Vorschulalter - Version III (BUEVA-III) was used, and for measuring mathematical performance the test Deutsche Mathematiktest fur erste Klassen (DEMAT 1+) was used. Before the training there were no group differences between the training and control group regarding mathematical performance and overall intelligence. The training showed positive short-term effects for numerical competencies in the last kindergarten year (medium effect size). While trained children could significantly improve their mathematical competencies to an average level (from 34 to 41 t-value points), the performances of the untrained children stayed below average. Unfortunately, there were no significant intermediate effects for mathematical performance in the second half of the first grade. Regarding the diagnosis of dyscalculia as defined by the ICD-10, it was not possible to gather a sufficiently large sample in the first grade fulfilling the criteria to test differences between training and control groups. Methodological limitations of this study were the missing random allocation to treatment conditions, a large drop-out rate, and long testing periods. The preschool training that was used to stimulate numerical competencies contributed significantly toward improving numerical competencies in the short term. Further investigations will determine the long-term effects of the training in the second and third grade. This is particularly important because dyscalculia occurring from the second grade on is a stable phenomenon. KW - developmental dyscalculia KW - numerical competence KW - prevention KW - risk KW - specific developmental disorder KW - Rechenstörung KW - Zahlen- und Mengenverständnis KW - Prävention KW - Risiko KW - Umschriebene Entwicklungsstörung Y1 - 2017 U6 - https://doi.org/10.1026/0942-5403/a000242 SN - 0942-5403 SN - 2190-6246 VL - 27 IS - 1 SP - 31 EP - 42 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Wiepke, Axel P. A1 - Miklashevsky, Alex T1 - Imaginary Worlds and Their Borders: An Opinion Article JF - Frontiers Media SA KW - imaginary world KW - fiction KW - narrative KW - embodied cognition KW - virtual reality KW - feeling of presence KW - mental simulation Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.793764 SN - 1664-1078 VL - 12 SP - 1 EP - 2 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Kühne, Franziska A1 - Hermann, Myriel A1 - Preisler, Martina A1 - Rohrmoser, Amy A1 - Letsch, Anne A1 - Goerling, Ute T1 - Prognostic Awareness in Advanced Disease BT - A Review Update and Concept Analysis JF - Frontiers in Psychology N2 - Purpose: Although subjective knowledge about the prognosis of an advanced disease is extremely important for coping and treatment planning, the concept of prognostic awareness (PA) remains inconsistently defined. The aims of the scoping review were to synthesize a definition of PA from the most recent literature, describe preconditions, correlates and consequences, and suggest a conceptual model. Methods: By using scoping review methodology, we searched the Web of Science and PubMed databases, and included publications, reviews, meta-analyses or guidelines on all physical diagnoses, as well as publications offering a conceptual or an operational definition of PA. The data were analyzed by means of content analysis techniques. Results: Of the 24 included publications, 21 referred exclusively to cancer, one to patients with hip fractures and two to palliative care in general. The deduced definition of PA comprised the following facets: adequate estimation of chances for recovery, knowledge of limited time to live, adequate estimation of life expectancy, knowledge of therapy goals, and knowledge of the course of the disease. Further content analysis results were mapped graphically and in a detailed table. Conclusion: There appears to be a lack of theoretical embedding of PA that in turn influences the methods used for empirical investigation. Drawing on a clear conceptual definition, longitudinal or experimental studies would be desirable. KW - prognosis KW - cancer KW - oncology KW - palliative care KW - patient-centered care KW - systematic review KW - advanced disease Y1 - 2020 U6 - https://doi.org/10.3389/fpsyg.2021.629050 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Mkaouer, Bessem A1 - Hammoudi-Nassib, Sarra A1 - Amara, Samiha A1 - Chaabene, Helmi T1 - Evaluating the physical and basic gymnastics skills assessment for International Gymnastics Federation JF - Biology of Sport N2 - This study aimed to determine the specific physical and basic gymnastics skills considered critical in gymnastics talent identification and selection as well as in promoting men's artistic gymnastics performances. Fifty-one boys from a provincial gymnastics team (age 11.03 ± 0.95 years; height 1.33 ± 0.05 m; body mass 30.01 ± 5.53 kg; body mass index [BMI] 16.89 ± 3.93 kg/m²) regularly competing at national level voluntarily participated in this study. Anthropometric measures as well as the men's artistic gymnastics physical test battery (i.e., International Gymnastics Federation [FIG] age group development programme) were used to assess the somatic and physical fitness profile of participants, respectively. The physical characteristics assessed were: muscle strength, flexibility, speed, endurance, and muscle power. Test outcomes were subjected to a principal components analysis to identify the most representative factors. The main findings revealed that power speed, isometric and explosive strength, strength endurance, and dynamic and static flexibility are the most determinant physical fitness aspects of the talent selection process in young male artistic gymnasts. These findings are of utmost importance for talent identification, selection, and development. KW - Young male gymnast KW - Fitness performance KW - Assessment KW - Selection KW - Development Y1 - 2018 U6 - https://doi.org/10.5114/biolsport.2018.78059 SN - 0860-021X SN - 2083-1862 VL - 35 IS - 4 SP - 383 EP - 392 PB - Inst Sport CY - Warsaw ER - TY - JOUR A1 - Adelt, Anne A1 - Hanne, Sandra A1 - Stadie, Nicole T1 - Treatment of sentence comprehension and production in aphasia BT - is there cross-modal generalisation? JF - Neuropsychological rehabilitation N2 - Exploring generalisation following treatment of language deficits in aphasia can provide insights into the functional relation of the cognitive processing systems involved. In the present study, we first review treatment outcomes of interventions targeting sentence processing deficits and, second report a treatment study examining the occurrence of practice effects and generalisation in sentence comprehension and production. In order to explore the potential linkage between processing systems involved in comprehending and producing sentences, we investigated whether improvements generalise within (i.e., uni-modal generalisation in comprehension or in production) and/or across modalities (i.e., cross-modal generalisation from comprehension to production or vice versa). Two individuals with aphasia displaying co-occurring deficits in sentence comprehension and production were trained on complex, non-canonical sentences in both modalities. Two evidence-based treatment protocols were applied in a crossover intervention study with sequence of treatment phases being randomly allocated. Both participants benefited significantly from treatment, leading to uni-modal generalisation in both comprehension and production. However, cross-modal generalisation did not occur. The magnitude of uni-modal generalisation in sentence production was related to participants’ sentence comprehension performance prior to treatment. These findings support the assumption of modality-specific sub-systems for sentence comprehension and production, being linked uni-directionally from comprehension to production. KW - Sentence comprehension KW - sentence production KW - cross-modal generalisation KW - aphasia treatment Y1 - 2016 U6 - https://doi.org/10.1080/09602011.2016.1213176 SN - 0960-2011 SN - 1464-0694 VL - 28 IS - 6 SP - 937 EP - 965 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Krause, Florian A1 - Meyer, Marlene A1 - Bekkering, Harold A1 - Hunnius, Sabine A1 - Lindemann, Oliver T1 - Interaction between perceptual and motor magnitudes in early childhood JF - Cognitive development N2 - Recent research has suggested that all types of size-related information are linked by a generalised system that codes for domain-independent magnitudes. This generalized system is further suggested to be acquired through everyday sensorimotor experiences with contingencies of size-related information in the real world. The aim of the present study was to investigate the existence of this common representation and its impact on the coupling of perception and action in early childhood. According to an embodied view on magnitude representation, an association between perceived magnitude information and size-related motor features, such as applied motor force, should emerge as soon as motor control is sufficiently developed. This hypothesis was tested in 2.5- to 3-year-old toddlers by engaging them in a computer game-like experimental task in which they were required to move objects placed on a platform upwards by pressing a button. The amount of objects was varied systematically (small amount: 3 vs. large amount: 15) and the force children applied on the button while moving the objects was recorded. Importantly, the amount of applied force was not relevant for successfully playing the game. The analysis of the peak force revealed that motor responses were executed more forcefully when children were presented with a large amount of objects compared to a small amount, irrespective of the toddler’s motor abilities which were evaluated by two additional measures (force control and general fine motor skills). This general effect of perceived magnitude information on the task-irrelevant applied motor force confirms our notion that a link between perceptual and motor magnitudes exists already in early childhood and provides new evidence for a sensorimotor grounding of magnitude concepts. KW - Perception-action coupling KW - Generalised magnitude system KW - Embodied cognition KW - motor development Y1 - 2018 U6 - https://doi.org/10.1016/j.cogdev.2018.11.001 SN - 0885-2014 SN - 1879-226X VL - 49 SP - 11 EP - 19 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Warschburger, Petra A1 - Petersen, Ann-Christin A1 - von Rezori, Roman Enzio A1 - Buchallik, Friederike A1 - Baumeister, Harald A1 - Holl, Reinhard A1 - Minden, Kirsten A1 - Müller-​Stierlin, Annabel Sandra A1 - Reinauer, Christina A1 - Staab, Doris A1 - COACH consortium, T1 - A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study JF - BMC Pediatrics N2 - Background Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions. Methods/design We plan to consecutively recruit N = 450 adolescents (12–21 years) from three German patient registries for chronic conditions (type 1 diabetes, cystic fibrosis, or juvenile idiopathic arthritis). Based on screening for anxiety and depression, adolescents are assigned to two parallel groups – “inconspicuous” (PHQ-9 and GAD-7 < 7) vs. “conspicuous” (PHQ-9 or GAD-7 ≥ 7) – participating in a prospective online survey at baseline and 12-month follow-up. At two time points (T1, T2), we assess (1) intra- and interpersonal resiliency factors, (2) coping strategies, and (3) health-related quality of life, well-being, satisfaction with life, anxiety and depression. Using a cross-lagged panel design, we will examine the bidirectional longitudinal relations between resiliency factors and coping strategies, psychological adaptation, and psychosocial adjustment. To monitor Covid-19 pandemic effects, participants are also invited to take part in an intermediate online survey. Discussion The study will provide a deeper understanding of adaptive, potentially modifiable processes and will therefore help to develop novel, tailored interventions supporting a positive adaptation in youths with a chronic condition. These strategies should not only support those at risk but also promote the maintenance of a successful adaptation. Trial registration German Clinical Trials Register (DRKS), no. DRKS00025125. Registered on May 17, 2021. KW - Chronic conditions KW - Adolescents KW - Prospective KW - Quality of life KW - Resiliency KW - Coping KW - Protective factors KW - Type 1 diabetes KW - Juvenile idiopathic arthritis KW - Cystic fibrosis Y1 - 2021 U6 - https://doi.org/10.1186/s12887-021-02869-9 SN - 1471-2431 VL - 21 SP - 1 EP - 13 PB - BMC pediatrics CY - London ER - TY - JOUR A1 - Zoch-Lesniak, Beate A1 - Dobberke, Jeanette A1 - Schlitt, Axel A1 - Bongarth, Christa A1 - Glatz, Johannes A1 - Spörl-Dönch, Sieglinde A1 - Koran, Iryna A1 - Völler, Heinz A1 - Salzwedel, Annett T1 - Performance Measures for Short-Term Cardiac Rehabilitation in Patients of Working Age BT - Results of the Prospective Observational Multicenter Registry OutCaRe JF - Archives of Rehabilitation Research and Clinical Translation N2 - Objective: To determine immediate performance measures for short-term, multicomponent cardiac rehabilitation (CR) in clinical routine in patients of working age, taking into account cardiovascular risk factors, physical performance, social medicine, and subjective health parameters and to explore the underlying dimensionality. Design: Prospective observational multicenter register study in 12 rehabilitation centers throughout Germany. Setting: Comprehensive 3-week CR. KW - Cardiac rehabilitation KW - Outcome measures KW - Cardiovascular diseases Y1 - 2019 U6 - https://doi.org/10.1016/j.arrct.2020.100043 SN - 2590-1095 VL - 2 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Eichler, Sarah A1 - Völler, Heinz A1 - Reibis, Rona Katharina A1 - Wegscheider, Karl A1 - Butter, Christian A1 - Harnath, Axel A1 - Salzwedel, Annett T1 - Geriatric or cardiac rehabilitation? BT - Predictors of treatment pathways in advanced age patients after transcatheter aortic valve implantation JF - BMC Cardiovascular Disorders N2 - Background Aim of the study was to find predictors of allocating patients after transcatheter aortic valve implantation (TAVI) to geriatric (GR) or cardiac rehabilitation (CR) and describe this new patient group based on a differentiated characterization. Methods From 10/2013 to 07/2015, 344 patients with an elective TAVI were consecutively enrolled in this prospective multicentric cohort study. Before intervention, sociodemographic parameters, echocardiographic data, comorbidities, 6-min walk distance (6MWD), quality of life and frailty (score indexing activities of daily living [ADL], cognition, nutrition and mobility) were documented. Out of these, predictors for assignment to CR or GR after TAVI were identified using a multivariable regression model. Results After TAVI, 249 patients (80.7 ± 5.1 years, 59.0% female) underwent CR (n = 198) or GR (n = 51). GR patients were older, less physically active and more often had a level of care, peripheral artery disease as well as a lower left ventricular ejection fraction. The groups also varied in 6MWD. Furthermore, individual components of frailty revealed prognostic impact: higher values in instrumental ADL reduced the probability for referral to GR (OR:0.49, p <  0.001), while an impaired mobility was positively associated with referral to GR (OR:3.97, p = 0.046). Clinical parameters like stroke (OR:0.19 of GR, p = 0.038) and the EuroSCORE (OR:1.04 of GR, p = 0.026) were also predictive. Conclusion Advanced age patients after TAVI referred to CR or GR differ in several parameters and seem to be different patient groups with specific needs, e.g. regarding activities of daily living and mobility. Thus, our data prove the eligibility of both CR and GR settings. KW - TAVI KW - Treatment pathways KW - Frailty KW - Geriatric rehabilitation Y1 - 2019 U6 - https://doi.org/10.1186/s12872-020-01452-x SN - 1471-2261 VL - 20 PB - BioMed Central CY - London ER - TY - JOUR A1 - Ciaccio, Laura Anna A1 - Burchert, Frank A1 - Semenza, Carlo T1 - Derivational morphology in agrammatic aphasia BT - a comparison between prefixed and suffixed words JF - Frontiers in Psychology N2 - Although a relatively large number of studies on acquired language impairments have tested the case of derivational morphology, none of these have specifically investigated whether there are differences in how prefixed and suffixed derived words are impaired. Based on linguistic and psycholinguistic considerations on prefixed and suffixed derived words, differences in how these two types of derivations are processed, and consequently impaired, are predicted. In the present study, we investigated the errors produced in reading aloud simple, prefixed, and suffixed words by three German individuals with agrammatic aphasia (NN, LG, SA). We found that, while NN and LG produced similar numbers of errors with prefixed and suffixed words, SA showed a selective impairment for prefixed words. Furthermore, NN and SA produced more errors specifically involving the affix with prefixed words than with suffixed words. We discuss our findings in terms of relative position of stem and affix in prefixed and suffixed words, as well as in terms of specific properties of prefixes and suffixes. KW - Broca’s aphasia KW - morphological decomposition KW - morphological errors KW - derivation KW - prefixes Y1 - 2019 U6 - https://doi.org/10.3389/fpsyg.2020.01070 SN - 1664-1078 VL - 11 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Kühne, Franziska A1 - Maas, Jana A1 - Wiesenthal, Sophia A1 - Weck, Florian T1 - Empirical research in clinical supervision BT - a systematic review and suggestions for future studies T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Background: Although clinical supervision is considered to be a major component of the development and maintenance of psychotherapeutic competencies, and despite an increase in supervision research, the empirical evidence on the topic remains sparse. Methods: Because most previous reviews lack methodological rigor, we aimed to review the status and quality of the empirical literature on clinical supervision, and to provide suggestions for future research. MEDLINE, PsycInfo and the Web of Science Core Collection were searched and the review was conducted according to current guidelines. From the review results, we derived suggestions for future research on clinical supervision. Results: The systematic literature search identified 19 publications from 15 empirical studies. Taking into account the review results, the following suggestions for further research emerged: Supervision research would benefit from proper descriptions of how studies are conducted according to current guidelines, more methodologically rigorous empirical studies, the investigation of active supervision interventions, from taking diverse outcome domains into account, and from investigating supervision from a meta-theoretical perspective. Conclusions: In all, the systematic review supported the notion that supervision research often lags behind psychotherapy research in general. Still, the results offer detailed starting points for further supervision research. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 580 KW - Supervision KW - Clinical supervision KW - Systematic review KW - Evidence-based psychotherapy Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-438721 SN - 1866-8364 IS - 580 ER - TY - JOUR A1 - Martinez-Ferreiro, Silvia A1 - de Aguiar, Vania A1 - Rofes, Adria T1 - Non-fluent aphasia in Ibero-Romance: a review of morphosyntactic deficits JF - Aphasiology : an international, interdisciplinary journal N2 - Background: Castilian-Spanish, Catalan, Galician, and European Portuguese are the most widely spoken languages of the Ibero-Romance group. An increasing number of authors have addressed the impact of aphasia on the morphosyntax of these varieties. However, accurate linguistic characterisations are scarce and the different sources of data have not been yet compiled.Aims: To stimulate state-of-the-art research, we provided a comprehensive summary of morphosyntactic aspects of Ibero-Romance and a review of how these are affected in non-fluent aphasia. The topics we dealt with are the use of verb argument structure and morphology, sentential negation and word order, definite articles, personal and reflexive pronouns, passives, topicalised constructions, questions, and relative clauses.Methods & Procedures: An exhaustive fieldwork and search of PubMed, Web of Science, and Medline records were performed to retrieve studies focused on morphosyntactic issues concerning the Ibero-Romance varieties. A total of 27 studies produced by 46 authors of varying background emerged. We did not review studies of category-specific deficits and aspects related to bilingual aphasia, although we assume that most speakers of Galician and Catalan are bilingual. Studies of spontaneous speech were included when no controlled experimental tasks were available.Outcomes & Results: The morphosyntactic commonalities of Ibero-Romance have been tackled from different theoretical perspectives. There exist asymmetries in findings which we explain with the use of different tasks (and task complexity) and individual differences between participants.Conclusions: Discourse-linking factors as well as deviations from the canonical pattern are recurrent answers to these asymmetries. A comprehensive theory of impairments in non-fluent aphasia integrating relevant aspects of both structural and processing accounts seems necessary. KW - non-fluent aphasia KW - morphosyntax KW - Ibero-Romance Y1 - 2015 U6 - https://doi.org/10.1080/02687038.2014.958915 SN - 0268-7038 SN - 1464-5041 VL - 29 IS - 1 SP - 101 EP - 126 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Warschburger, Petra A1 - Zitzmann, Jana T1 - Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study BT - Results from a Controlled Study T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Research on weight-loss interventions in emerging adulthood is warranted. Therefore, a cognitive-behavioral group treatment (CBT), including development-specific topics for adolescents and young adults with obesity (YOUTH), was developed. In a controlled study, we compared the efficacy of this age-specific CBT group intervention to an age-unspecific CBT group delivered across ages in an inpatient setting. The primary outcome was body mass index standard deviation score (BMI-SDS) over the course of one year; secondary outcomes were health-related and disease-specific quality of life (QoL). 266 participants aged 16 to 21 years (65% females) were randomized. Intention-to-treat (ITT) and per-protocol analyses (PPA) were performed. For both group interventions, we observed significant and clinically relevant improvements in BMI-SDS and QoL over the course of time with small to large effect sizes. Contrary to our hypothesis, the age-specific intervention was not superior to the age-unspecific CBT-approach. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 584 KW - adolescents KW - emerging adults KW - behavioral weight loss KW - obesity KW - controlled trial KW - quality of life Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-439424 SN - 1866-8364 IS - 584 ER - TY - JOUR A1 - Puerto Valencia, Laura Maria A1 - Arampatzis, Adamantios A1 - Beck, Heidrun A1 - Dreinhöfer, Karsten E. A1 - Drießlein, Drießlein A1 - Mau, Wilfried A1 - Zimmer, Julia-Marie A1 - Schäfer, Michael A1 - Steinfeldt, Friedemann A1 - Wippert, Pia-Maria T1 - RENaBack: Low back pain patients in rehabilitation: Study Protocol for a Multicenter, Randomized Controlled Trial JF - Trials N2 - Background Millions of people in Germany suffer from chronic pain, in which course and intensity are multifactorial. Besides physical injuries, certain psychosocial risk factors are involved in the disease process. The national health care guidelines for the diagnosis and treatment of non-specific low back pain recommend the screening of psychosocial risk factors as early as possible, to be able to adapt the therapy to patient needs (e.g., unimodal or multimodal). However, such a procedure has been difficult to implement in practice and has not yet been integrated into the rehabilitation care structures across the country. Methods The aim of this study is to implement an individualized therapy and aftercare program within the rehabilitation offer of the German Pension Insurance in the area of orthopedics and to examine its success and sustainability in comparison to the previous standard aftercare program. The study is a multicenter randomized controlled trial including 1204 patients from six orthopedic rehabilitation clinics. A 2:1 allocation ratio to intervention (individualized and home-based rehabilitation aftercare) versus the control group (regular outpatient rehabilitation aftercare) is set. Upon admission to the rehabilitation clinic, participants in the intervention group will be screened according to their psychosocial risk profile. They could then receive either unimodal or multimodal, together with an individualized training program. The program is instructed in the clinic (approximately 3 weeks) and will continue independently at home afterwards for 3 months. The success of the program is examined by means of a total of four surveys. The co-primary outcomes are the Characteristic Pain Intensity and Disability Score assessed by the German version of the Chronic Pain Grade questionnaire (CPG). Discussion An improvement in terms of pain, work ability, patient compliance, and acceptance in our intervention program compared to the standard aftercare is expected. The study contributes to provide individualized care also to patients living far away from clinical centers. Trial registration DRKS, DRKS00020373. Registered on 15 April 2020 KW - Chronic low back pain KW - Aftercare KW - Individualized therapy KW - Randomized controlled trial KW - Rehabilitation Y1 - 2021 U6 - https://doi.org/10.1186/s13063-021-05823-3 SN - 1745-6215 SP - 1 EP - 18 PB - Springer Nature / BMC CY - Heidelberg ER - TY - JOUR A1 - Stuchtey, Fidelis Christin A1 - Block, Andrea A1 - Osei, Francis A1 - Wippert, Pia-Maria T1 - Lipid Biomarkers in Depression: Does Antidepressant Therapy Have an Impact? JF - Healthcare : open access journal N2 - Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL (p = 0.041), LDL (p < 0.001), and total cholesterol (p < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference (p = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients. KW - major depressive disorder KW - antidepressants KW - high density lipoprotein cholesterol KW - HDL KW - low density lipoprotein cholesterol KW - LDL KW - cholesterol KW - triglycerides KW - lipids Y1 - 2022 U6 - https://doi.org/10.3390/healthcare10020333 SN - 2227-9032 VL - 10 SP - 1 EP - 11 PB - MDPI CY - Basel, Schweiz ET - 2 ER - TY - GEN A1 - Quarmby, Andrew A1 - Mönnig, Jamal A1 - Mugele, Hendrik A1 - Henschke, Jakob A1 - Kim, MyoungHwee A1 - Cassel, Michael A1 - Engel, Tilman T1 - Biomechanics and lower limb function are altered in athletes and runners with achilles tendinopathy compared with healthy controls: A systematic review T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Achilles tendinopathy (AT) is a debilitating injury in athletes, especially for those engaged in repetitive stretch-shortening cycle activities. Clinical risk factors are numerous, but it has been suggested that altered biomechanics might be associated with AT. No systematic review has been conducted investigating these biomechanical alterations in specifically athletic populations. Therefore, the aim of this systematic review was to compare the lower-limb biomechanics of athletes with AT to athletically matched asymptomatic controls. Databases were searched for relevant studies investigating biomechanics during gait activities and other motor tasks such as hopping, isolated strength tasks, and reflex responses. Inclusion criteria for studies were an AT diagnosis in at least one group, cross-sectional or prospective data, at least one outcome comparing biomechanical data between an AT and healthy group, and athletic populations. Studies were excluded if patients had Achilles tendon rupture/surgery, participants reported injuries other than AT, and when only within-subject data was available.. Effect sizes (Cohen's d) with 95% confidence intervals were calculated for relevant outcomes. The initial search yielded 4,442 studies. After screening, twenty studies (775 total participants) were synthesised, reporting on a wide range of biomechanical outcomes. Females were under-represented and patients in the AT group were three years older on average. Biomechanical alterations were identified in some studies during running, hopping, jumping, strength tasks and reflex activity. Equally, several biomechanical variables studied were not associated with AT in included studies, indicating a conflicting picture. Kinematics in AT patients appeared to be altered in the lower limb, potentially indicating a pattern of “medial collapse”. Muscular activity of the calf and hips was different between groups, whereby AT patients exhibited greater calf electromyographic amplitudes despite lower plantar flexor strength. Overall, dynamic maximal strength of the plantar flexors, and isometric strength of the hips might be reduced in the AT group. This systematic review reports on several biomechanical alterations in athletes with AT. With further research, these factors could potentially form treatment targets for clinicians, although clinical approaches should take other contributing health factors into account. The studies included were of low quality, and currently no solid conclusions can be drawn. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 830 KW - achilles tendinopathy KW - biomechanics KW - neuromuscular KW - kinetics KW - electromyography KW - athletes KW - runners KW - kinematics Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-587603 SN - 1866-8364 IS - 830 ER - TY - JOUR A1 - Quarmby, Andrew A1 - Mönnig, Jamal A1 - Mugele, Hendrik A1 - Henschke, Jakob A1 - Kim, MyoungHwee A1 - Cassel, Michael A1 - Engel, Tilman T1 - Biomechanics and lower limb function are altered in athletes and runners with achilles tendinopathy compared with healthy controls: A systematic review JF - Frontiers in Sports and Active Living N2 - Achilles tendinopathy (AT) is a debilitating injury in athletes, especially for those engaged in repetitive stretch-shortening cycle activities. Clinical risk factors are numerous, but it has been suggested that altered biomechanics might be associated with AT. No systematic review has been conducted investigating these biomechanical alterations in specifically athletic populations. Therefore, the aim of this systematic review was to compare the lower-limb biomechanics of athletes with AT to athletically matched asymptomatic controls. Databases were searched for relevant studies investigating biomechanics during gait activities and other motor tasks such as hopping, isolated strength tasks, and reflex responses. Inclusion criteria for studies were an AT diagnosis in at least one group, cross-sectional or prospective data, at least one outcome comparing biomechanical data between an AT and healthy group, and athletic populations. Studies were excluded if patients had Achilles tendon rupture/surgery, participants reported injuries other than AT, and when only within-subject data was available.. Effect sizes (Cohen's d) with 95% confidence intervals were calculated for relevant outcomes. The initial search yielded 4,442 studies. After screening, twenty studies (775 total participants) were synthesised, reporting on a wide range of biomechanical outcomes. Females were under-represented and patients in the AT group were three years older on average. Biomechanical alterations were identified in some studies during running, hopping, jumping, strength tasks and reflex activity. Equally, several biomechanical variables studied were not associated with AT in included studies, indicating a conflicting picture. Kinematics in AT patients appeared to be altered in the lower limb, potentially indicating a pattern of “medial collapse”. Muscular activity of the calf and hips was different between groups, whereby AT patients exhibited greater calf electromyographic amplitudes despite lower plantar flexor strength. Overall, dynamic maximal strength of the plantar flexors, and isometric strength of the hips might be reduced in the AT group. This systematic review reports on several biomechanical alterations in athletes with AT. With further research, these factors could potentially form treatment targets for clinicians, although clinical approaches should take other contributing health factors into account. The studies included were of low quality, and currently no solid conclusions can be drawn. KW - achilles tendinopathy KW - biomechanics KW - neuromuscular KW - kinetics KW - electromyography KW - athletes KW - runners KW - kinematics Y1 - 2023 U6 - https://doi.org/10.3389/fspor.2022.1012471 SN - 2624-9367 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Frank, Ulrike A1 - Czepluch, C. A1 - Sticher, H. A1 - Maetzener, F. A1 - Schlaegel, W. A1 - Mäder, M. T1 - Modifiziertes Trachealkanülenmanagement - Platzhaltereinsatz als Option bei erschwerten Dekanülierungen (Pilotprojekt REHAB Basel) JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Tracheotomierte Patienten, die sowohl eine Dysphagie als auch respiratorische Defizite aufweisen, haben nach der Dekanülierung häufig Probleme, sich an die translaryngeale Atmung anzupassen. Wir entwickelten ein Dekanülierungsprotokoll für diese Patientengruppe, das optional in unser bestehendes Trachealkanülenmanagement integriert werden kann. Erfüllt ein Patient die hierfür definierten Kriterien, so erfolgt unter laryngoskopischer Kontrolle die Einlage eines Platzhalters, der bis zu 3 Tage in situ verbleibt. Während dieser Probedekanülierungsphase werden die respiratorischen Funktionen und das Speichelmanagement engmaschig überwacht. Auf der Grundlage dieser Evaluation wird dann die Entscheidung für oder gegen eine endgültige Dekanülierung getroffen. Wir stellen den Ablauf, die Kriterienkataloge und die Evaluationsparameter für diese Probedekanülierungsphase vor und illustrieren den Ablauf anhand von 2 Fallbeispielen. KW - decannulation protocol KW - dilatational tracheostomy KW - stoma button KW - respiration KW - dysphagia Y1 - 2013 U6 - https://doi.org/10.1055/s-0032-1306290 SN - 0034-3536 VL - 52 IS - 1 SP - 20 EP - 26 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Ghahghaei, Saeideh A1 - Linnell, Karina J. A1 - Fischer, Martin H. A1 - Dubey, Amit A1 - Davis, Robert T1 - Effects of load on the time course of attentional engagement, disengagement, and orienting in reading JF - The quarterly journal of experimental psychology N2 - We examined how the frequency of the fixated word influences the spatiotemporal distribution of covert attention during reading. Participants discriminated gaze-contingent probes that occurred with different spatial and temporal offsets from randomly chosen fixation points during reading. We found that attention was initially focused at fixation and that subsequent defocusing was slower when the fixated word was lower in frequency. Later in a fixation, attention oriented more towards the next saccadic target for high- than for low-frequency words. These results constitute the first report of the time course of the effect of load on attentional engagement and orienting in reading. They are discussed in the context of serial and parallel models of reading. KW - Attention KW - Load KW - Reading KW - Time course KW - Word frequency KW - Engagement KW - Disengagement KW - Orienting Y1 - 2013 U6 - https://doi.org/10.1080/17470218.2011.635795 SN - 1747-0218 VL - 66 IS - 3 SP - 453 EP - 470 PB - Wiley CY - Hove ER - TY - JOUR A1 - De Bleser, Ria T1 - History of aphasia : negative optic aphasia ; how much semantics does a name need? ; Wolff's re- examination of Voit N2 - Background: A prominent model of semantic processing in modern cognitive psychology proposes that semantic memory originates in everyday life experience with concrete objects such as plants, animals, and tools (Martin Chao, 2001). When the meaning of a concrete content word is being acquired, the learner is confronted with stimuli of various modalities related to the word's meaning. This comes to be stored as sensory knowledge about the object. It is further postulated that there is a conceptual domain remote from the mechanisms of perception, which is often referred to as functional knowledge or verbal semantics. There is a large body of neuropsychological literature trying to establish how much sensory and functional semantics is needed to access a name, and whether the relative contribution of these types of knowledge is the same for all categories of objects. Another controversial issue is whether naming requires access to semantic knowledge, or whether object names can be accessed directly from vision without the intervention of semantics, as is generally accepted for written word naming. Some support for this assumption seems to come from cases of so-called non-optic aphasia, a condition in which patients can name from visual presentation only but not from any other modality of presentation such as auditory, verbal, tactile, etc. In optic aphasia, a condition far better established, naming is possible from all modalities except vision. Aims: The aim of this paper is to draw attention to the first case description of non-optic or negative optic aphasia described by Wolff (1897, 1904). Methods Procedures: The case describes the results of a re-examination of Voit, who was seen by several neurologists in the course of a decade in classical aphasiology. The patient demonstrated anomia in oral but not in written naming of objects in view. Wolff's examination involves extensive testing of semantic processing in several modalities, especially with respect to the status of functional and sensory semantic features Outcomes Results: The re-examination of patient Voit by Wolff in 1897 with new procedures revealed a specific impairment in processing sensory knowledge, while functional knowledge of objects was relatively preserved. This led to a naming impairment in all modalities of presentation except the visual one. Using more refined tasks, Wolff also demonstrated receptive impairments, in contrast to previous researchers who had concluded that the impairment was restricted to oral production. Conclusions: Although Wolff's (1904) case of negative optic aphasia has been almost completely forgotten (but see Bartels Wallesch, 1996), it is astonishingly modern in its conceptual approach and in the central questions it addresses on the mechanisms involved in the process of naming and on the structure of the semantic system. As is usual in classical cases, the methodology may appear less stringent than in most contemporary work, but the approach was brilliant. Y1 - 2009 UR - http://www.informaworld.com/smpp/title~content=t713393920~db=all U6 - https://doi.org/10.1080/02687030802593197 SN - 0268-7038 ER - TY - JOUR A1 - Scheepers, Christoph A1 - Mohr, Sibylle A1 - Fischer, Martin H. A1 - Roberts, Andrew M. T1 - Listening to Limericks - A Pupillometry Investigation of Perceivers' Expectancy JF - PLoS one N2 - What features of a poem make it captivating, and which cognitive mechanisms are sensitive to these features? We addressed these questions experimentally by measuring pupillary responses of 40 participants who listened to a series of Limericks. The Limericks ended with either a semantic, syntactic, rhyme or metric violation. Compared to a control condition without violations, only the rhyme violation condition induced a reliable pupillary response. An anomaly-rating study on the same stimuli showed that all violations were reliably detectable relative to the control condition, but the anomaly induced by rhyme violations was perceived as most severe. Together, our data suggest that rhyme violations in Limericks may induce an emotional response beyond mere anomaly detection. Y1 - 2013 U6 - https://doi.org/10.1371/journal.pone.0074986 SN - 1932-6203 VL - 8 IS - 9 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Brand, Ralf A1 - Wolff, Wanja A1 - Hoyer, Jürgen T1 - Psychological Symptoms and Chronic Mood in Representative Samples of Elite Student-Athletes, Deselected Student-Athletes and Comparison Students JF - School mental health : a multidisciplinary research and practice journal N2 - Stress-levels experienced by school-aged elite athletes are pronounced, but data on their mental health status are widely lacking. In our study, we examined self-reported psychological symptoms and chronic mood. Data from a representative sample of 866 elite student-athletes (aged 12-15 years), enrolled in high-performance sport programming in German Elite Schools of Sport, were compared with data from 80 student-athletes from the same schools who have just been deselected from elite sport promotion, and from 432 age-and sex-matched non-sport students from regular schools (without such programming). Anxiety symptoms were least prevalent in female elite student-athletes. In male elite student-athletes, only symptoms of posttraumatic stress were less prevalent than in the other groups. Somatoform symptoms were generally more frequent in athletes, a trend that was significantly pronounced in deselected athletes. Deselected athletes showed an increased risk for psychological symptoms compared with both other groups. Regarding chronic mood, again deselected athletes showed less positive scores. While there was a trend toward high-performance sport being associated with better psychological health at least in girls, preventative programs should take into account that deselection from elite sport programming may be associated with specific risks for mental disorders. KW - School KW - Mental health KW - Mental disorders KW - Competitive sport KW - Forced drop-out Y1 - 2013 U6 - https://doi.org/10.1007/s12310-012-9095-8 SN - 1866-2625 SN - 1866-2633 VL - 5 IS - 3 SP - 166 EP - 174 PB - Springer CY - New York ER - TY - JOUR A1 - Huber, Matthias A1 - Treszl, Andras A1 - Reibis, Rona Katharina A1 - Teichmann, Christopher A1 - Zergibel, Irina A1 - Bolbrinker, Juliane A1 - Scholze, Juergen A1 - Wegscheider, Karl A1 - Völler, Heinz A1 - Kreutz, Reinhold T1 - Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines JF - European journal of internal medicine : official journal of the European Federation of Internal Medicine N2 - Background: Melatonin exerts multiple biological effects with potential impact on human diseases. This is underscored by genetic studies that demonstrated associations between melatonin receptor type 2 gene (MTNR1B) polymorphisms and characteristics of type 2 diabetes. We set out to test the hypothesis whether genetic variants at MTNR1B are also relevant for other disease phenotypes within the cardiovascular continuum. We thus investigated single nucleotide polymorphisms (SNPs) of MTNR1B in relation to blood pressure (BP) and cardiac parameters in hypertensive patients. Methods: Patients (n = 605, mean age 56.2 +/- 9.4 years, 82.3% male) with arterial hypertension and cardiac ejection fraction (EF) >= 40% were studied. Cardiac parameters were assessed by echocardiography. Results: The cohort comprised subjects with coronary heart disease (73.1%) and myocardial infarction (48.1%) with a mean EF of 63.7 +/- 8.9%. Analysis of SNPs rs10830962, rs4753426, rs12804291, rs10830963, and rs3781638 revealed two haplotypes 1 and 2 with frequencies of 0.402 and 0.277, respectively. Carriers with haplotype 1 (CTCCC) showed compared to non-carriers a higher mean 24-hour systolic BP (difference BP: 2.4 mm Hg, 95% confidence interval (CI): 0.3 to 4.5 mm Hg, p = 0.023). Haplotype 2 (GCCGA) was significantly related to EF with an absolute increase of 1.8% (CI: 0.45 to 3.14%) in carriers versus non-carriers (p = 0.009). Conclusion: Genetics of MTNR1B point to impact of the melatonin signalling pathway for BP and left ventricular function. This may support the importance of the melatonin system as a potential therapeutic target. KW - Clinical study KW - Genetics KW - Heart KW - Hypertension KW - Melatonin receptor type 2 Y1 - 2013 U6 - https://doi.org/10.1016/j.ejim.2013.03.015 SN - 0953-6205 VL - 24 IS - 7 SP - 650 EP - 655 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Völler, Heinz A1 - Salzwedel, Annett A1 - Reibis, Rona Katharina A1 - Kaminski, S. A1 - Buhlert, Hermann A1 - Eichler, Sarah A1 - Wegscheider, Karl T1 - Age and fitness level are strongest limitations of exercise capacity during inpatient cardiac rehabilitation T2 - European heart journal Y1 - 2014 SN - 0195-668X SN - 1522-9645 VL - 35 SP - 899 EP - 899 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Sixtus, Elena A1 - Lindemann, Oliver A1 - Fischer, Martin H. T1 - The flexibility of finger-based magnitude representations T2 - Cognitive processing : international quarterly of cognitive science Y1 - 2014 SN - 1612-4782 SN - 1612-4790 VL - 15 IS - 1 SP - S68 EP - S69 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Wiebking, Christine A1 - de Greck, Moritz A1 - Duncan, Niall W. A1 - Tempelmann, Claus A1 - Bajbouj, Malek A1 - Northoff, Georg T1 - Interoception in insula subregions as a possible state marker for depression - an exploratory fMRI study investigating healthy, depressed and remitted participants JF - Frontiers in behavioral neuroscience N2 - Background: Interoceptive awareness, the awareness of stimuli originating inside the body, plays an important role in human emotions and psychopathology. The insula is particularly involved in neural processes underlying iA. However, iA-related neural activity in the insula during the acute state of major depressive disorder (MDD) and in remission from depression has not been explored. Methods: A well-established fMRI paradigm for studying interoceptive awareness (iA; heartbeat counting) and exteroceptive awareness (eA; tone counting) was used. Study participants formed three independent groups: patients suffering from MDD, patients in remission from MDD or healthy controls. Task-induced neural activity in three functional subdivisions of the insula was compared between these groups. Results: Depressed participants showed neural hypo-responses during iA in anterior insula regions, as compared to both healthy and remitted participants. The right dorsal anterior insula showed the strongest response to iA across all participant groups. In depressed participants there was no differentiation between different stimuli types in this region (i.e., between iA, eA and noTask). Healthy and remitted participants in contrast showed clear activity differences. Conclusions: This is the first study comparing iA and eA-related activity in the insula in depressed participants to that in healthy and remitted individuals. The preliminary results suggest that these groups differ in there being hypo-responses across insula regions in the depressed participants, whilst healthy participants and patients in remission from MDD show the same neural activity during iA in insula subregions implying a possible state marker for MDD. The lack of activity differences between different stimulus types in the depressed group may account for their symptoms of altered external and internal focus. KW - major depressive disorder KW - interoceptive awareness KW - insula KW - remission KW - neuroimaging KW - fMRI Y1 - 2015 U6 - https://doi.org/10.3389/fnbeh.2015.00082 SN - 1662-5153 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hartmann, Matthias A1 - Martarelli, Corinna S. A1 - Mast, Fred W. A1 - Stocker, Kurt T1 - Eye movements during mental time travel follow a diagonal line JF - Consciousness and cognition N2 - Recent research showed that past events are associated with the back and left side, whereas future events are associated with the front and right side of space. These spatial-temporal associations have an impact on our sensorimotor system: thinking about one's past and future leads to subtle body sways in the sagittal dimension of space (Miles, Nind, & Macrae, 2010). In this study we investigated whether mental time travel leads to sensorimotor correlates in the horizontal dimension of space. Participants were asked to mentally displace themselves into the past or future while measuring their spontaneous eye movements on a blank screen. Eye gaze was directed more rightward and upward when thinking about the future than when thinking about the past. Our results provide further insight into the spatial nature of temporal thoughts, and show that not only body, but also eye movements follow a (diagonal) "time line" during mental time travel. (C) 2014 Elsevier Inc. All rights reserved. KW - Mental time travel KW - Eye movements KW - Mental time line KW - Spatial-temporal association KW - Future KW - Past KW - Embodied cognition KW - Metaphors KW - Mental number line Y1 - 2014 U6 - https://doi.org/10.1016/j.concog.2014.09.007 SN - 1053-8100 SN - 1090-2376 VL - 30 SP - 201 EP - 209 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Williams, Daniel A1 - Escudero, Paola T1 - A cross-dialectal acoustic comparison of vowels in Northern and Southern British English JF - The journal of the Acoustical Society of America N2 - This study compares the duration and first two formants (F1 and F2) of 11 nominal monophthongs and five nominal diphthongs in Standard Southern British English (SSBE) and a Northern English dialect. F1 and F2 trajectories were fitted with parametric curves using the discrete cosine transform (DCT) and the zeroth DCT coefficient represented formant trajectory means and the first DCT coefficient represented the magnitude and direction of formant trajectory change to characterize vowel inherent spectral change (VISC). Cross-dialectal comparisons involving these measures revealed significant differences for the phonologically back monophthongs /D, , , u:/ and also /3z:/ and the diphthongs /eI, e, aI, I/. Most cross-dialectal differences are in zeroth DCT coefficients, suggesting formant trajectory means tend to characterize such differences, while first DCT coefficient differences were more numerous for diphthongs. With respect to VISC, the most striking differences are that /u:/is considerably more diphthongized in the Northern dialect and that the F2 trajectory of /e/proceeds in opposite directions in the two dialects. Cross-dialectal differences were found to be largely unaffected by the consonantal context in which the vowels were produced. The implications of the results are discussed in relation to VISC, consonantal context effects and speech perception. (c) 2014 Acoustical Society of America. Y1 - 2014 U6 - https://doi.org/10.1121/1.4896471 SN - 0001-4966 SN - 1520-8524 VL - 136 IS - 5 SP - 2751 EP - 2761 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Williams, Daniel A1 - Escudero, Paola T1 - Influences of listeners' native and other dialects on cross-language vowel perception JF - Frontiers in psychology KW - non-native speech perception KW - native dialects KW - non-native dialects KW - speech production KW - acoustic phonetics Y1 - 2014 U6 - https://doi.org/10.3389/fpsyg.2014.01065 SN - 1664-1078 VL - 5 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Salzwedel, Annett A1 - Nosper, Manfred A1 - Roehrig, Bernd A1 - Linck-Eleftheriadis, Sigrid A1 - Strandt, Gert A1 - Völler, Heinz T1 - Outcome quality of in-patient cardiac rehabilitation in elderly patients - identification of relevant parameters JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Background: Outcome quality management requires the consecutive registration of defined variables. The aim was to identify relevant parameters in order to objectively assess the in-patient rehabilitation outcome. Methods: From February 2009 to June 2010 1253 patients (70.9 +/- 7.0 years, 78.1% men) at 12 rehabilitation clinics were enrolled. Items concerning sociodemographic data, the impairment group (surgery, conservative/interventional treatment), cardiovascular risk factors, structural and functional parameters and subjective health were tested in respect of their measurability, sensitivity to change and their propensity to be influenced by rehabilitation. Results: The majority of patients (61.1%) were referred for rehabilitation after cardiac surgery, 38.9% after conservative or interventional treatment for an acute coronary syndrome. Functionally relevant comorbidities were seen in 49.2% (diabetes mellitus, stroke, peripheral artery disease, chronic obstructive lung disease). In three key areas 13 parameters were identified as being sensitive to change and subject to modification by rehabilitation: cardiovascular risk factors (blood pressure, low-density lipoprotein cholesterol, triglycerides), exercise capacity (resting heart rate, maximal exercise capacity, maximal walking distance, heart failure, angina pectoris) and subjective health (IRES-24 (indicators of rehabilitation status): pain, somatic health, psychological well-being and depression as well as anxiety on the Hospital Anxiety and Depression Scale). Conclusion: The outcome of in-patient rehabilitation in elderly patients can be comprehensively assessed by the identification of appropriate key areas, that is, cardiovascular risk factors, exercise capacity and subjective health. This may well serve as a benchmark for internal and external quality management. KW - Cardiac rehabilitation KW - quality management KW - outcome measures Y1 - 2014 U6 - https://doi.org/10.1177/2047487312469475 SN - 2047-4873 SN - 2047-4881 VL - 21 IS - 2 SP - 172 EP - 180 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Roehrig, B. A1 - Nosper, M. A1 - Linck-Eleftheriadis, S. A1 - Strandt, G. A1 - Salzwedel, Annett A1 - Völler, Heinz T1 - Method of the assessment of patients Outcome in cardiac rehabilitation by means of quality indicators - a description of the method JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Introduction: Cardiac rehabilitation is designed for patients suffering from cardiovascular diseases or functional disabilities. The aim of a cardiac rehabilitation is to improve overall physical health, psychological well-being, physical function, the ability to participate in social life and help patients to change their habits. Regarding the heterogeneity of these aims measuring of the effect of cardiac rehabilitation is still a challenge. This study recommends a concept to assess the effects of cardiac rehabilitation regarding the individual change of relevant quality indicators. Methods: With EVA-Reha; cardiac rehabilitation the Medical Advisory Service of Statutory Health Insurance Funds in Rhineland-Palatinate, Alzey (MDK Rheinland-Pfalz) developed a software to collect data set including sociodemographic and diagnostic data and also the results of specific assessments. The project was funded by the Techniker Krankenkasse, Hamburg, and supported by participating rehabilitation centers. From 01. July 2010 to 30. June 2011 1309 patients (age 71.5 years, 76.1% men) from 13 rehabilitation centers were consecutively enrolled. 13 quality indicators in 3 scales were developed for evaluation of cardiac rehabilitation: 1) cardiovascular risk factors (blood pressure, LDL cholesterol, triglycerides), 2) exercise capacity (resting heart rate, maximal exercise capacity, maximal walking distance, heart failure [NYHA classification], and angina pectoris [CCS classification]) and 3) subjective health (IRES-24: pain, somatic health, psychological wellbeing and depression as well as anxiety on the HADS). The study was prospective; data of patients were assessed at entry and discharge of rehabilitation. To measure the success of rehabilitation each parameter was graded in severity classes at entry and discharge. For each of the 13 quality indicators changes of severity class were rated in a rating matrix. For indicators without a requirement for medical care neither at entry nor at discharge no rating was performed. Results: The grading into severity classes as well as the minimal important differences were given for the 13 quality indicators. The result of rehabilitation can be demonstrated in suitable form by means of rating of the 13 quality indicators according to a clinical population. The rating model differs well between clinically changed and unchanged patients for the quality indicators. Conclusion: The result of cardiac rehabilitation can be assessed with 13 quality indicators measured at entry and discharge of the rehabilitation program. If a change into a more favorable category at the end of rehabilitation could be achieved it was counted as a success. The 13 quality indicators can be used to assess the individual result as well as the result of a population - e.g. all patients of a clinic in a specific time period. In addition, the assessment and rating of relevant quality indicators can be used for comparisons of rehabilitation centers. KW - cardiac rehabilitation KW - quality indicator KW - outcome KW - success KW - quality management Y1 - 2014 U6 - https://doi.org/10.1055/s-0033-1341457 SN - 0034-3536 SN - 1439-1309 VL - 53 IS - 1 SP - 31 EP - 37 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Sidiropoulos, Kyriakos A1 - De Bleser, Ria A1 - Ablinger, Irene A1 - Ackermann, Hermann T1 - The relationship between verbal and nonverbal auditory signal processing in conduction aphasia: behavioral and anatomical evidence for common decoding mechanisms JF - Neurocase : the neural basis of cognition N2 - The processing of nonverbal auditory stimuli has not yet been sufficiently investigated in patients with aphasia. On the basis of a duration discrimination task, we examined whether patients with left-sided cerebrovascular lesions were able to perceive time differences in the scale of approximately 150ms. Further linguistic and memory-related tasks were used to characterize more exactly the relationships in the performances between auditory nonverbal task and selective linguistic or mnemonic disturbances. All examined conduction aphasics showed increased thresholds in the duration discrimination task. The low thresholds on this task were in a strong correlative relation to the reduced performances in repetition and working memory task. This was interpreted as an indication of a pronounced disturbance in integrating auditory verbal information into a long-term window (sampling disturbance) resulting in an additional load of working memory. In order to determine the lesion topography of patients with sampling disturbances, the anatomical and psychophysical data were correlated on the basis of a voxelwise statistical approach. It was found that tissue damage extending through the insula, the posterior superior temporal gyrus, and the supramarginal gyrus causes impairments in sequencing of time-sensitive information. KW - brain lesions KW - conduction aphasia KW - processing of auditory nonverbal stimuli KW - speech perception KW - speech pathology KW - lesion studies Y1 - 2015 U6 - https://doi.org/10.1080/13554794.2014.902471 SN - 1355-4794 SN - 1465-3656 VL - 21 IS - 3 SP - 377 EP - 393 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Wasner, Mirjam A1 - Möller, Korbinian A1 - Fischer, Martin H. A1 - Nuerk, Hans-Christoph T1 - Related but not the same: Ordinality, cardinality and 1-to-1 correspondence in finger-based numerical representations JF - Journal of cognitive psychology N2 - Finger-based numerical representations have gained increasing research interest. However, their description and assessment often refer to different numerical principles of ordinality, cardinality and 1-to-1 correspondence. Our aim was to investigate similarities and differences between these principles in finger-based numerical representations. Sixty-eight healthy adults performed ordinal finger counting, cardinal finger montring (showing the number of gestures) and finger-to-number mapping with twisted arms and fingers. We found that counting gestures and montring postures were identical for Number 10 but differed to varying degrees for other numbers. Interestingly, there was no systematic relation between finger-to-number mapping and ordinal finger counting habits. These data question the assumption of a unitary embodied finger-based numerical representation, but suggest that different finger-based representations co-exist and can be recruited flexibly depending on the numerical aspects to be conveyed. KW - Finger-based numerical representations KW - Finger counting KW - 1-to-1 Correspondence KW - Cardinality KW - Ordinality Y1 - 2015 U6 - https://doi.org/10.1080/20445911.2014.964719 SN - 2044-5911 SN - 2044-592X VL - 27 IS - 4 SP - 426 EP - 441 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - CHAP A1 - Nitardy, Aischa A1 - Salzwedel, Annett A1 - Wegscheider, Karl A1 - Jawari, Amir A1 - Buhlert, Hermann A1 - Völler, Heinz T1 - Effect of cardiac rehabilitation on functional and emotional status in patients after transcatheter aortic-valve replacement T2 - Circulation : an American Heart Association journal KW - Cardiac rehabilitation KW - TAVI KW - Transcatheter Aortic Valve Implantation KW - Aortic valve KW - Exercise tests Y1 - 2012 SN - 0009-7322 SN - 1524-4539 VL - 126 IS - 21 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - INPR A1 - Baumann, Stefan A1 - Kügler, Frank T1 - Prosody and information status in typological perspective - Introduction to the Special Issue T2 - Lingua : international review of general linguistics Y1 - 2015 U6 - https://doi.org/10.1016/j.lingua.2015.08.001 SN - 0024-3841 SN - 1872-6135 VL - 165 SP - 179 EP - 182 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Genzel, Susanne A1 - Ishihara, Shinichiro A1 - Suranyi, Balazs T1 - The prosodic expression of focus, contrast and givenness: A production study of Hungarian JF - Lingua : international review of general linguistics N2 - This paper reports the results of a production experiment that explores the prosodic realization of focus in Hungarian, a language that is characterized by obligatory syntactic focus marking. Our study investigates narrow focus in sentences in which focus is unambiguously marked by syntactic means, comparing it to broad focus sentences. Potential independent effects of the salience (textual givenness) of the background of the narrow focus and the contrastiveness of the focus are controlled for and are also examined. The results show that both continuous phonetic measures and categorical factors such as the distribution of contour types are affected by the focus-related factors, despite the presence of syntactic focus marking. The phonetic effects found are mostly parallel to those of typical prosodic focus marking languages like English. The prosodic prominence required of focus is realized through changes to the scaling and slope of F0 targets and contours. The asymmetric prominence relation between the focus and the background can be expressed not only by the phonetic marking of the prominence of the focused element, but also by the phonetic marking of the reduced prominence of the background. Furthermore, contrastiveness of focus and (textual) givenness of the background show independent phonetic effects, both of them affecting the realization of the background. These results are argued to shed light on alternative approaches to the information structural notion of contrastive focus and the relation between the notions of focus and givenness. (C) 2014 Elsevier B.V. All rights reserved. KW - Hungarian KW - Prosody KW - Focus KW - Background KW - Givenness KW - Contrast Y1 - 2015 U6 - https://doi.org/10.1016/j.lingua.2014.07.010 SN - 0024-3841 SN - 1872-6135 VL - 165 SP - 183 EP - 204 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Verhoeven, Elisabeth A1 - Kügler, Frank T1 - Accentual preferences and predictability: An acceptability study on split intransitivity in German JF - Lingua : international review of general linguistics N2 - The difference in the default prosodic realization of simple sentences with unergative vs. unaccusative/passive verbs (assigning early nuclear accent with unaccusative/passive verbs but late nuclear accent with unergative verbs) is often related to the syntactic distinction of their nominative arguments as starting off in different hierarchical positions. Alternative accounts try to trace this prosodic variation back to asymmetries in the semantic or pragmatic contribution of the verb to an utterance. The present article investigates the interaction of the assignment of default nuclear accent with the predictability of the verb. In an experimental study testing the acceptability of nuclear accent assignment, we confirmed that the predictability of the verb influences accentual preferences (such that highly predictable verbs are preferably not accented). However, the experiment also reveals that the unaccusativity distinction cannot be accounted for by means of pragmatic phenomena of this type: the two verb classes are associated with distinct accentual patterns in the baseline condition, that is, without the predictability manipulation. (C) 2014 Elsevier B.V. All rights reserved. KW - Nuclear accent KW - Prosodic phrasing KW - Unaccusativity KW - Unergative verbs KW - Predictability KW - Information structure Y1 - 2015 U6 - https://doi.org/10.1016/j.lingua.2014.09.013 SN - 0024-3841 SN - 1872-6135 VL - 165 SP - 298 EP - 315 PB - Elsevier CY - Amsterdam ER - TY - INPR A1 - Reibis, Rona Katharina A1 - Gaede-Illig, Cathleen A1 - Völler, Heinz T1 - Rehabilitation after Acute Myocardial Infarction T2 - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation Y1 - 2014 U6 - https://doi.org/10.1055/s-0034-1370119 SN - 0034-3536 SN - 1439-1309 VL - 53 IS - 3 SP - 191 EP - 201 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Muckelbauer, Rebecca A1 - Englert, Heike A1 - Rieckmann, Nina A1 - Chen, Chih-Mei A1 - Wegscheider, Karl A1 - Völler, Heinz A1 - Katus, Hugo A. A1 - Willich, Stefan N. A1 - Müller-Nordhorn, Jacqueline T1 - Long-term effect of a low-intensity smoking intervention embedded in an adherence program for patients with hypercholesterolemia: Randomized controlled trial JF - Preventive medicine : an international journal devoted to practice and theory N2 - Objective. We evaluated the long-term effect of a smoking intervention embedded in an adherence program in patients with an increased risk for cardiovascular disease. Method. Secondary analysis of a randomized controlled trial: In 2002-2004,8108 patients with hypercholesterolemia were enrolled from general practices in Germany. Patients received a 12-month adherence program and statin medication (intervention) or statin medication only (control). The program aimed to improve adherence to medication and lifestyle by educational material, mailings, and phone calls. Smoking was self-reported at baseline and every 6 months during the 3-year follow-up. Results. In total, 7640 patients were analyzed. At baseline, smoking prevalence was 21.7% in the intervention and 21.5% in the control group. Prevalence decreased in both groups to 16.6% vs. 19.5%, 153% vs. 16.8%, and 14.2% vs. 15.6% at the 12-, 24-, and 36-month follow-up. The intervention had a beneficial effect on smoking differing over time (group x time: P = 0.005). The effect was largest after 6 and 12 months [odds ratios (95% confidence intervals): 0.67 (0.54-0.82) and 0.63 (0.51-0.78)]. The effect decreased until the 18-month follow-up [0.72 (0.58-0.90)] and was not significant after 24 months. Conclusion. A low-intensity smoking intervention embedded in an adherence program can contribute to smoking cessation although the intervention effect diminished over time. (C) 2015 Elsevier Inc. All rights reserved. KW - Smoking KW - Smoking cessation KW - Cardiovascular risk factors KW - Health promotion KW - Randomized controlled trial KW - Multiple risk factor intervention KW - Hypercholesterolemia Y1 - 2015 U6 - https://doi.org/10.1016/j.ypmed.2015.05.026 SN - 0091-7435 SN - 1096-0260 VL - 77 SP - 155 EP - 161 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Pinhas, Michal A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Addition goes where the big numbers are: evidence for a reversed operational momentum effect JF - Psychonomic bulletin & review : a journal of the Psychonomic Society N2 - Number processing evokes spatial biases, both when dealing with single digits and in more complex mental calculations. Here we investigated whether these two biases have a common origin, by examining their flexibility. Participants pointed to the locations of arithmetic results on a visually presented line with an inverted, right-to-left number arrangement. We found directionally opposite spatial biases for mental arithmetic and for a parity task administered both before and after the arithmetic task. We discuss implications of this dissociation in our results for the task-dependent cognitive representation of numbers. KW - Mental arithmetic KW - Mental number line KW - Operational momentum KW - Pointing KW - SNARC Y1 - 2015 U6 - https://doi.org/10.3758/s13423-014-0786-z SN - 1069-9384 SN - 1531-5320 VL - 22 IS - 4 SP - 993 EP - 1000 PB - Springer CY - New York ER - TY - JOUR A1 - Krajenbrink, Trudy A1 - Nickels, Lyndsey A1 - Kohnen, Saskia T1 - Generalisation after treatment of acquired spelling impairments: A review JF - Neuropsychological rehabilitation N2 - This paper provides a comprehensive review of treatment studies of acquired dysgraphia and the occurrence of generalisation after this treatment. The aim is to examine what determines the occurrence of generalisation by investigating the link between the level of impairment, the method of treatment, and the outcome of therapy. We present the outcomes of treatment with regard to generalisation in 40 treatment studies. We derive general principles of generalisation which provide us with a better understanding of the mechanism of generalisation: (1) Direct treatment effects on representations or processes; (2) interactive processing and summation of activation; and (3) strategies and compensatory skills. We discuss the implications of these findings for our understanding of the cognitive processes used for spelling. Finally, we provide suggestions for the direction of further research into this important area, as a better understanding of the mechanism of generalisation could maximise treatment effects for an individual with acquired dysgraphia. KW - Generalisation KW - Spelling KW - Treatment KW - Acquired dysgraphia Y1 - 2015 U6 - https://doi.org/10.1080/09602011.2014.983135 SN - 0960-2011 SN - 1464-0694 VL - 25 IS - 4 SP - 503 EP - 554 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Hofmann, Reiner A1 - Völler, Heinz A1 - Nagels, Klaus A1 - Bindl, Dominik A1 - Vettorazzi, Eik A1 - Dittmar, Ronny A1 - Wohlgemuth, Walter A1 - Neumann, Till A1 - Störk, Stefan A1 - Bruder, Oliver A1 - Wegscheider, Karl A1 - Nagel, Eckhard A1 - Fleck, Eckart T1 - First outline and baseline data of a randomized, controlled multicenter trial to evaluate the health economic impact of home telemonitoring in chronic heart failure - CardioBBEAT JF - Trials N2 - Background: Evidence that home telemonitoring for patients with chronic heart failure (CHF) offers clinical benefit over usual care is controversial as is evidence of a health economic advantage. Methods: Between January 2010 and June 2013, patients with a confirmed diagnosis of CHF were enrolled and randomly assigned to 2 study groups comprising usual care with and without an interactive bi-directional remote monitoring system (Motiva (R)). The primary endpoint in CardioBBEAT is the Incremental Cost-Effectiveness Ratio (ICER) established by the groups' difference in total cost and in the combined clinical endpoint "days alive and not in hospital nor inpatient care per potential days in study" within the follow-up of 12 months. Results: A total of 621 predominantly male patients were enrolled, whereof 302 patients were assigned to the intervention group and 319 to the control group. Ischemic cardiomyopathy was the leading cause of heart failure. Despite randomization, subjects of the control group were more often in NYHA functional class III-IV, and exhibited peripheral edema and renal dysfunction more often. Additionally, the control and intervention groups differed in heart rhythm disorders. No differences existed regarding risk factor profile, comorbidities, echocardiographic parameters, especially left ventricular and diastolic diameter and ejection fraction, as well as functional test results, medication and quality of life. While the observed baseline differences may well be a play of chance, they are of clinical relevance. Therefore, the statistical analysis plan was extended to include adjusted analyses with respect to the baseline imbalances. Conclusions: CardioBBEAT provides prospective outcome data on both, clinical and health economic impact of home telemonitoring in CHF. The study differs by the use of a high evidence level randomized controlled trial (RCT) design along with actual cost data obtained from health insurance companies. Its results are conducive to informed political and economic decision-making with regard to home telemonitoring solutions as an option for health care. Overall, it contributes to developing advanced health economic evaluation instruments to be deployed within the specific context of the German Health Care System. KW - Home telemonitoring KW - Chronic heart failure (CHF) KW - Incremental Cost-Effectiveness Ratio (ICER) KW - Mortality KW - Telemedicine KW - Health economics Y1 - 2015 U6 - https://doi.org/10.1186/s13063-015-0886-8 SN - 1745-6215 VL - 16 PB - BioMed Central CY - London ER - TY - JOUR A1 - Huber, Matthias A1 - Lezius, Susanne A1 - Reibis, Rona Katharina A1 - Treszl, Andras A1 - Kujawinska, Dorota A1 - Jakob, Stefanie A1 - Wegscheider, Karl A1 - Völler, Heinz A1 - Kreutz, Reinhold T1 - A Single Nucleotide Polymorphism near the CYP17A1 Gene Is Associated with Left Ventricular Mass in Hypertensive Patients under Pharmacotherapy JF - International journal of molecular sciences N2 - Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this background, we investigated associations between single nucleotide polymorphisms (SNPs) in or nearby the CYP17A1 gene with BP and left ventricular mass in patients with arterial hypertension and associated cardiovascular organ damage treated according to guidelines. Patients (n = 1007, mean age 58.0 +/- 9.8 years, 83% men) with arterial hypertension and cardiac left ventricular ejection fraction (LVEF) 40% were enrolled in the study. Cardiac parameters of left ventricular mass, geometry and function were determined by echocardiography. The cohort comprised patients with coronary heart disease (n = 823; 81.7%) and myocardial infarction (n = 545; 54.1%) with a mean LVEF of 59.9% +/- 9.3%. The mean left ventricular mass index (LVMI) was 52.1 +/- 21.2 g/m(2.7) and 485 (48.2%) patients had left ventricular hypertrophy. There was no significant association of any investigated SNP (rs619824, rs743572, rs1004467, rs11191548, rs17115100) with mean 24 h systolic or diastolic BP. However, carriers of the rs11191548 C allele demonstrated a 7% increase in LVMI (95% CI: 1%-12%, p = 0.017) compared to non-carriers. The CYP17A1 polymorphism rs11191548 demonstrated a significant association with LVMI in patients with arterial hypertension and preserved LVEF. Thus, CYP17A1 may contribute to cardiac hypertrophy in this clinical condition. KW - clinical study KW - genetics KW - heart KW - hypertension KW - cytochrome P450 17A1 (Cyp17A1) Y1 - 2015 U6 - https://doi.org/10.3390/ijms160817456 SN - 1422-0067 VL - 16 IS - 8 SP - 17456 EP - 17468 PB - MDPI CY - Basel ER - TY - CHAP A1 - Völler, Heinz A1 - Salzwedel, Annett A1 - Reibis, Rona Katharina A1 - Eichler, Sarah A1 - Buhlert, Hermann A1 - Kaminski, Stefan A1 - Wegscheider, Karl T1 - Cardiopulmonary exercise testing is predictive of return to work in cardiac patients after multicomponent rehabilitation T2 - European heart journal Y1 - 2015 SN - 0195-668X SN - 1522-9645 VL - 36 SP - 635 EP - 636 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Völler, Heinz A1 - Eichler, Sarah A1 - Harnath, Axel A1 - Kamke, Wolfram A1 - Butter, Christian A1 - Kraehe, Mathias A1 - Schikora, Martin A1 - Jachczyk, J. A1 - Salzwedel, Annett T1 - Case management in patients after TAVI: are frailty and exercise capacitiy predictors for decision making process? T2 - European heart journal Y1 - 2015 SN - 0195-668X SN - 1522-9645 VL - 36 SP - 635 EP - 635 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Apel, Jens K. A1 - Revie, Gavin F. A1 - Cangelosi, Angelo A1 - Ellis, Rob A1 - Goslin, Jeremy A1 - Fischer, Martin H. T1 - Attention deployment during memorizing and executing complex instructions JF - Experimental brain research N2 - We investigated the mental rehearsal of complex action instructions by recording spontaneous eye movements of healthy adults as they looked at objects on a monitor. Participants heard consecutive instructions, each of the form "move [object] to [location]''. Instructions were only to be executed after a go signal, by manipulating all objects successively with a mouse. Participants re-inspected previously mentioned objects already while listening to further instructions. This rehearsal behavior broke down after 4 instructions, coincident with participants' instruction span, as determined from subsequent execution accuracy. These results suggest that spontaneous eye movements while listening to instructions predict their successful execution. KW - Assembly task KW - Eye movements KW - Overt attention KW - Rehearsal KW - Sequential instruction KW - Working memory Y1 - 2011 U6 - https://doi.org/10.1007/s00221-011-2827-4 SN - 0014-4819 VL - 214 IS - 2 SP - 249 EP - 259 PB - Springer CY - New York ER - TY - JOUR A1 - Ringwald, Juergen A1 - Lehmann, Marina A1 - Niemeyer, Nicole A1 - Seifert, Isabel A1 - Daubmann, Anne A1 - Wegscheider, Karl A1 - Salzwedel, Annett A1 - Luxembourg, Beate A1 - Eckstein, Reinhold A1 - Völler, Heinz T1 - Travel habits and complications in patients treated with vitamin K antagonists: A cross sectional analysis JF - Travel medicine and infectious disease N2 - Background: Travel-related conditions have impact on the quality of oral anticoagulation therapy (OAT) with vitamin K-antagonists. No predictors for travel activity and for travel-associated haemorrhage or thromboembolic complications of patients on OAT are known. Methods: A standardised questionnaire was sent to 2500 patients on long-term OAT in Austria, Switzerland and Germany. 997 questionnaires were received (responder rate 39.9%). Ordinal or logistic regression models with travel activity before and after onset of OAT or travel-associated haemorrhages and thromboembolic complications as outcome measures were applied. Results: 43.4% changed travel habits since onset of OAT with 24.9% and 18.5% reporting decreased or increased travel activity, respectively. Long-distance worldwide before OAT or having suffered from thromboembolic complications was associated with reduced travel activity. Increased travel activity was associated with more intensive travel experience, increased duration of OAT, higher education, or performing patient self-management (PSM). Travel-associated haemorrhages or thromboennbolic complications were reported by 6.5% and 0.9% of the patients, respectively. Former thromboennbolic complications, former bleedings and PSM were significant predictors of travel-associated complications. Conclusions: OAT also increases travel intensity. Specific medical advice prior travelling to prevent complications should be given especially to patients with former bleedings or thromboennbolic complications and to those performing PSM. (C) 2014 Elsevier Ltd. All rights reserved. KW - Vitamin k-antagonists KW - Oral anticoagulation KW - Travel KW - Patient self-management Y1 - 2014 U6 - https://doi.org/10.1016/j.tmaid.2014.02.006 SN - 1477-8939 SN - 1873-0442 VL - 12 IS - 3 SP - 258 EP - 263 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Knudsen, Birgit A1 - Fischer, Martin H. A1 - Aschersleben, Gisa T1 - Development of spatial preferences for counting and picture naming JF - Psychological research : an international journal of perception, attention, memory, and action N2 - The direction of object enumeration reflects children's enculturation but previous work on the development of such spatial preferences has been inconsistent. Therefore, we documented directional preferences in finger counting, object counting, and picture naming for children (4 groups from 3 to 6 years, N = 104) and adults (N = 56). We found a right-side preference for finger counting in 3- to 6-year-olds and a left-side preference for counting objects and naming pictures by 6 years of age. Children were consistent in their special preferences when comparing object counting and picture naming, but not in other task pairings. Finally, spatial preferences were not related to cardinality comprehension. These results, together with other recent work, suggest a gradual development of spatial-numerical associations from early non-directional mappings into culturally constrained directional mappings. Y1 - 2015 U6 - https://doi.org/10.1007/s00426-014-0623-z SN - 0340-0727 SN - 1430-2772 VL - 79 IS - 6 SP - 939 EP - 949 PB - Springer CY - Heidelberg ER -