TY - THES A1 - Radeff, Giuditta T1 - Geohistory of the Central Anatolian Plateau southern margin (southern Turkey) T1 - Die geologische Entwicklung des südlichen zentralsanatolischen Plateaurandes (Süd-Türkei) N2 - The Adana Basin of southern Turkey, situated at the SE margin of the Central Anatolian Plateau is ideally located to record Neogene topographic and tectonic changes in the easternmost Mediterranean realm. Using industry seismic reflection data we correlate 34 seismic profiles with corresponding exposed units in the Adana Basin. The time-depth conversion of the interpreted seismic profiles allows us to reconstruct the subsidence curve of the Adana Basin and to outline the occurrence of a major increase in both subsidence and sedimentation rates at 5.45 – 5.33 Ma, leading to the deposition of almost 1500 km3 of conglomerates and marls. Our provenance analysis of the conglomerates reveals that most of the sediment is derived from and north of the SE margin of the Central Anatolian Plateau. A comparison of these results with the composition of recent conglomerates and the present drainage basins indicates major changes between late Messinian and present-day source areas. We suggest that these changes in source areas result of uplift and ensuing erosion of the SE margin of the plateau. This hypothesis is supported by the comparison of the Adana Basin subsidence curve with the subsidence curve of the Mut Basin, a mainly Neogene basin located on top of the Central Anatolian Plateau southern margin, showing that the Adana Basin subsidence event is coeval with an uplift episode of the plateau southern margin. The collection of several fault measurements in the Adana region show different deformation styles for the NW and SE margins of the Adana Basin. The weakly seismic NW portion of the basin is characterized by extensional and transtensional structures cutting Neogene deposits, likely accomodating the differential uplift occurring between the basin and the SE margin of the plateau. We interpret the tectonic evolution of the southern flank of the Central Anatolian Plateau and the coeval subsidence and sedimentation in the Adana Basin to be related to deep lithospheric processes, particularly lithospheric delamination and slab break-off. N2 - Il Bacino di Adana (Turchia meridionale) é situato in posizione esterna rispetto al margine sud-orientale del plateau anatolico centrale. Il bacino risulta ubicato in posizione strategica per registrare i principali cambiamenti della topografia e dell’assetto tettonico avvenuti durante il Neogene nel Mediterraneo orientale. Utilizzando dati sismici provenienti dall’industria petrolifera abbiamo correlato 34 profili sismici con le unitá corrispondenti affioranti nel Bacino di Adana. La conversione da tempi a profonditá dei profili sismici interpretati ci ha permesso di ricostruire la curva di subsidenza del Bacino di Adana e di individuare un evento caratterizato da un importante aumento della subsidenza associato ad un considerevole incremento del tasso di sedimentazione. Questo evento, avvenuto tra 5.45 e 5.33 Ma ha portato alla deposizione di quasi 1500 km3 di conglomerati e marne. La nostra analisi di provenienza della porzione conglomeratica mostra che la maggior parte del sedimento proviene dal margine sud-orientale del plateau anatolico centrale e dalle aree situate a nord di questo. La comparazione di questi risultati con la composizione litologica di conglomerati recenti e con le litologie affioranti nei bacini di drenaggio attuali mostra cambiamenti rilevanti tra le aree di provenienza del sedimento Messiniane e quelle attuali. Riteniamo che questi cambiamenti nelle aree sorgente siano il risultato del sollevamento e della successiva erosione del margine sud-orientale del plateau anatolico centrale. Questa ipotesi é supportata dal confronto delle curve di subsidenza del Bacino di Adana e del Bacino di Mut, un bacino principalmente neogenico situato sulla sommitá del margine meridionale del plateau. La comparazione delle due curve di subsidenza mostra che l’evento di forte subsidenza del Bacino di Adana é coevo ad un episodio di sollevamento del margine meridionale del plateau anatolico centrale. La raccolta di un fitto dataset strutturale acquisito nella regione di Adana mostra differenti stili deformativi per i margini nord-occidentale e sud-orientale del bacino. La porzione nord-occidentale del bacino, debolmente sismica, é caratterizzata da strutture estensionali e transtensive che tagliano I depositi neogenici, verosimilmente accomodando il sollevamento differenziale tra il bacino e il margine sud-orientale del plateau. Riteniamo che l’evoluzione tettonica del margine meridionale del plateau anatolico centrale e la contemporanea subsidenza e sedimentazione nel Bacino di Adana sia da ricondurre a processi litosferici profondi, in particolar modo delaminazione litosferica e slab break-off. KW - Hebung des Plateaus KW - Sedimentenabfolge KW - Subsidenzgeschichte KW - Adana Becken KW - Süd-Türkei KW - plateau uplift KW - sedimentary record KW - subsidence history KW - Adana Basin KW - southern Turkey Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-71865 ER - TY - CHAP A1 - Märker, Michael A1 - Schröder-Esselbach, Boris A1 - Capolongo, Domenico A1 - Bentivenga, Mario T1 - Geomorphological and pedological processes in badland areas of Southern Italy and their interaction with Mediterranean vegetation N2 - Interdisziplinäres Zentrum für Musterdynamik und Angewandte Fernerkundung Workshop vom 9. - 10. Februar 2006 Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-7288 N1 - [Poster] ER - TY - GEN A1 - Hoffmann, Arthur A1 - Longhurst, Kerry T1 - German strategic culture and the changing role of the Bundeswehr N2 - The article mobilises the concept of strategic culture in order to identify the impact of history upon contemporary security policy. The article will first look at the "wholesale construction" of a strategic culture after the Second World War in West Germany before exploring its impact upon security policy since the end of the Cold War in two areas: the Bundeswehr's out-of-area role and conscription. The central argument presented here is that the strategic culture of the former Federal Republic now writ large on to the new united Germany sets the context within which security policies are designed. This strategic culture, as will be argued, acts as both a facilitating and a restraining variable on behaviour, making certain policy options possible and others impossible. Y1 - 1999 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-11448 ER - TY - JOUR A1 - Harvey, David T1 - Globalization and the “Spatial Fix” JF - Geographische Revue : Zeitschrift für Literatur und Diskussion Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-24366 SN - 1438-3039 VL - 3 IS - 2 SP - 23 EP - 30 ER - TY - CHAP A1 - Saget, Sylvie A1 - Guyomard, Marc T1 - Goal-oriented dialog as a collaborative subordinated activity involving collective acceptance N2 - Modeling dialog as a collaborative activity consists notably in specifying the contain of the Conversational Common Ground and the kind of social mental state involved. In previous work (Saget, 2006), we claim that Collective Acceptance is the proper social attitude for modeling Conversational Common Ground in the particular case of goal-oriented dialog. We provide a formalization of Collective Acceptance, besides elements in order to integrate this attitude in a rational model of dialog are provided; and finally, a model of referential acts as being part of a collaborative activity is provided. The particular case of reference has been chosen in order to exemplify our claims. Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-10420 ER - TY - BOOK ED - Van Hal, Toon ED - Vielle, Christophe T1 - Grammatica Grandonica BT - the Sanskrit Grammar of Johann Ernst Hanxleden S.J. (1681-1732) [introduced and edited by Toon Van Hal & Christophe Vielle, with a photographical reproduction of the original manuscript by Jean-Claude Muller] N2 - In May 2010, Johann Ernst Hanxleden’s Grammatica Grandonica was rediscovered in Montecompatri (Lazio, Rome). Although historiographers attached much weight to the nearly oldest western grammar of Sanskrit, the precious manuscript was lost for several decades. The first aim of the present digital publication is to offer a photographical reproduction of the manuscript. This facsimile is accompanied by a double edition: a facing diplomatic edition with the Sanskrit in Malayāḷam script, followed by a transliterated established text. KW - Sanskrit KW - Hanxleden KW - Grandonica KW - Grammatica KW - Arnos Padiri Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-63218 ER - TY - JOUR A1 - Csáky, Moritz T1 - Habsburg Central Europe BT - Culturally Heterogeneous and Polysemous Regions JF - PaRDeS N2 - Central Europe is characterized by linguistic and cultural density as well as by endogenous and exogenous cultural influences. These constellations were especially visible in the former Habsburg Empire, where they influenced the formation of individual and collective identities. This led not only to continual crises and conflicts, but also to an equally enormous creative potential as became apparent in the culture of the fin-de-siècle. Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-645995 SN - 978-3-86956-574-3 SN - 1614-6492 SN - 1862-7684 IS - 29 SP - 31 EP - 37 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - RPRT A1 - Graeber, Daniel A1 - Schikora, Felicitas T1 - Hate is too great a burden to bear BT - Hate crimes and the mental health of refugees T2 - CEPA Discussion Papers N2 - Against a background of increasing violence against non-natives, we estimate the effect of hate crime on refugees’ mental health in Germany. For this purpose, we combine two datasets: administrative records on xenophobic crime against refugee shelters by the Federal Criminal Office and the IAB-BAMF-SOEP Survey of Refugees. We apply a regression discontinuity in time design to estimate the effect of interest. Our results indicate that hate crime has a substantial negative effect on several mental health indicators, including the Mental Component Summary score and the Patient Health Questionnaire-4 score. The effects are stronger for refugees with closer geographic proximity to the focal hate crime and refugees with low country-specific human capital. While the estimated effect is only transitory, we argue that negative mental health shocks during the critical period after arrival have important long-term consequences. Keywords: Mental health, hate crime, migration, refugees, human capital. T3 - CEPA Discussion Papers - 31 KW - mental health KW - hate crime KW - migration KW - refugees KW - human capital Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-507972 SN - 2628-653X IS - 31 ER - TY - JOUR A1 - Lüdeling, Anke T1 - Heterogeneity and standardization in data, use, and annotation BT - a diachronic corpus of german JF - Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632 N2 - This paper describes the standardization problems that come up in a diachronic corpus: it has to cope with differing standards with regard to diplomaticity, annotation, and header information. Such highly het-erogeneous texts must be standardized to allow for comparative re-search without (too much) loss of information. Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-8643 SN - 1866-4725 SN - 1614-4708 IS - 2 SP - 43 EP - 54 ER - TY - JOUR A1 - Klempin, Christiane A1 - Rehfeldt, Daniel T1 - How to Promote and Measure Reflective Skills in Depth and Breadth of English and Physics Teacher Trainees JF - Reflexion in der Lehrkräftebildung: Empirisch – Phasenübergreifend – Interdisziplinär (Potsdamer Beiträge zur Lehrerbildung und Bildungsforschung ; 4) N2 - Supporting reflection in preservice during university-based training is, without doubt, a crucial aspect in attaining teacher professionalism. Therefore, an on-campus seminar designed to relate theory to practice and vice versa – the so-called ‘Lehr-Lern-Labor-Seminar (LLLS)’ – was implemented over the course of five terms to stimulate reflective skills of English and Physics teacher trainees. Investigations on the effectiveness of three types of the LLLS (no video and two types of video-supported reflections) compared to a parallel group (PG) and a control group (CG) occurred in a mixed methods quasi-experimental study. Reflective skills were elicited with vignettes, relevant covariates with questionnaires. Reflective development was then traced in the dimensions depth and breadth employing a qualitative content analysis. MANCOVA (Multivariate Analysis of Covariance) and regression analyses revealed a substantive increase of reflective depth for English and Physics teacher trainees and breadth development for English LLLS-participants in contrast to both, a PG and a CG, even when controlling for the subjects’ individual prerequisites. KW - reflective skills KW - mixed methods KW - reflective depth KW - reflective breadth KW - English and Physics teacher trainees Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-619381 SN - 978-3-86956-566-8 SN - 2626-3556 SN - 2626-4722 IS - 4 SP - 115 EP - 121 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Dimigen, Olaf A1 - Valsecchi, Matteo A1 - Sommer, Werner A1 - Kliegl, Reinhold T1 - Human Microsaccade-Related Visual Brain Responses N2 - Microsaccades are very small, involuntary flicks in eye position that occur on average once or twice per second during attempted visual fixation. Microsaccades give rise to EMG eye muscle spikes that can distort the spectrum of the scalp EEG and mimic increases in gamma band power. Here we demonstrate that microsaccades are also accompanied by genuine and sizeable cortical activity, manifested in the EEG. In three experiments, high-resolution eye movements were corecorded with the EEG: during sustained fixation of checkerboard and face stimuli and in a standard visual oddball task that required the counting of target stimuli. Results show that microsaccades as small as 0.15° generate a field potential over occipital cortex and midcentral scalp sites 100 –140 ms after movement onset, which resembles the visual lambda response evoked by larger voluntary saccades. This challenges the standard assumption of human brain imaging studies that saccade-related brain activity is precluded by fixation, even when fully complied with. Instead, additional cortical potentials from microsaccades were present in 86% of the oddball task trials and of similar amplitude as the visual response to stimulus onset. Furthermore, microsaccade probability varied systematically according to the proportion of target stimuli in the oddball task, causing modulations of late stimulus-locked event-related potential (ERP) components. Microsaccades present an unrecognized source of visual brain signal that is of interest for vision research and may have influenced the data of many ERP and neuroimaging studies. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - paper 240 Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-56923 ER - TY - CHAP A1 - Runacres, M. C. T1 - Hydrodynamical models of clumping beyond 50 R∗ N2 - We present one-dimensional, time-dependent models of the clumps generated by the linedeshadowing instability. In order to follow the clumps out to distances of more than 1000 R∗, we use an efficient moving-box technique. We show that, within the approximations, the wind can remain clumped well into the formation region of the radio continuum. Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-18030 ER - TY - GEN A1 - Elsenbeer, Helmut A1 - West, Adam A1 - Bonell, Mike T1 - Hydrologic pathways and stormflow hydrochemistry at South Creek, northeast Queensland N2 - Earlier investigations at South Creek in northeastern Queensland established the importance of overland flow as a hydrologic pathway in this tropical rainforest environment. Since this pathway is ‘fast’, transmitting presumably ‘new’ water, its importance should be reflected in the stormflow chemistry of South Creek: the greater the volumentric contribution to the stormflow hydrograph, the more similarity between the chemical composition of streamwater and of overland flow is to be expected. Water samples were taken during two storm events in an ephemeral gully (gully A), an intermittent gully (gully B) and at the South Creek catchment outlet; additional spot checks were made in several poorly defined rills. The chemical composition of ‘old’ water was determined from 45 baseflow samples collected throughout February. The two events differed considerably in their magnitudes, intensities and antecedent moisture conditions. In both events, the stormflow chemistry in South Creek was characterized by a sharp decrease in Ca, Mg, Na, Si, Cl, EC, ANC, alkalinity and total inorganic carbon. pH remained nearly constant with discharge, whereas K increased sharply, as did sulfate in an ill-defined manner. In event 1, this South Creek stormflow pattern was closely matched by the pattern in gully A, implying a dominant contribution of ‘new’ water. This match was confirmed by the spot samples from rills. Gully B behaved like South Creek itself, but with a dampened ‘new’ water signal, indicating less overland flow generation in its subcatchment. In event 2, which occurred five days later, the initial ‘new’ water signal in gully A was rapidly overwhelmed by a different signal which is attributed to rapid drainage from a perched water table. This study shows that stormflow in this rainforest catchment consists predominantly of ‘new’ water which reaches the stream channel via ‘fast’ pathways. Where the ephemeral gullies delivering overland flow are incised deeply enough to intersect a perched water table, a delayed, ‘old’ water-like signal may be transmitted. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 046 Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16904 ER - TY - CHAP A1 - Morrison, N. D. A1 - Rother, R. A1 - Kurschat, N. T1 - Hα line profile variability in the B8Ia-type supergiant Rigel (β Ori) N2 - Hα observations of Rigel obtained on 184 nights during the past ten years with the 1-m telescope and ´echelle spectrograph of Ritter Observatory are surveyed. The line profiles were classified in terms of morphology. About 1/4 of them are of P Cygni type, about 15% inverse P Cygni, about 25% double-peaked, about 1/3 pure absorption, and a few are single emission lines. Transformation of the profile from one type to another typically takes a few days. Although the line stays in absorption for extended intervals, only one high-velocity absorption event of the intensity reported by Kaufer et al. (1996a) was observed, in late 2006. Late in this event, Hα absorption occurred farther to the red than the red wing of a plausible photospheric absorption component, an indication of infalling material. In general, as the absorption events come to an end, the emission typically returns with an inverse P Cygni profile. The Hα profile class shows no obvious correlation with the radial velocity of C II λ6578, a photospheric absorption line. Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-18120 ER - TY - CHAP A1 - Artstein, Ron A1 - Poesio, Massimo T1 - Identifying reference to abstract objects in dialogue N2 - In two experiments, many annotators marked antecedents for discourse deixis as unconstrained regions of text. The experiments show that annotators do converge on the identity of these text regions, though much of what they do can be captured by a simple model. Demonstrative pronouns are more likely than definite descriptions to be marked with discourse antecedents. We suggest that our methodology is suitable for the systematic study of discourse deixis. Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-10357 ER - TY - CHAP A1 - Sonneborn, G. T1 - Imaging and spectroscopy with the James Webb Space Telescope N2 - The James Webb Space Telescope (JWST) is a large, infrared-optimized space telescope scheduled for launch in 2013. JWST will find the first stars and galaxies that formed in the early universe, connecting the Big Bang to our own Milky Way galaxy. JWST will peer through dusty clouds to see stars forming planetary systems, connecting the MilkyWay to our own Solar System. JWST’s instruments are designed to work primarily in the infrared range of 1 - 28 μm, with some capability in the visible range. JWST will have a large mirror, 6.5 m in diameter, and will be diffraction-limited at 2 μm (0.1 arcsec resolution). JWST will be placed in an L2 orbit about 1.5 million km from the Earth. The instruments will provide imaging, coronography, and multi-object and integral-field spectroscopy across the 1 - 28 μm wavelength range. The breakthrough capabilities of JWST will enable new studies of massive star winds from the Milky Way to the early universe. Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-17983 ER - TY - JOUR A1 - Musa Alokpo, Dieudonné T1 - Implementation of a Proposal Writing Workshop in the Democratic Republic of Congo BT - Challenges, Approaches, and Learning Outcomes of the Participants JF - Potsdamer Beiträge zur Hochschulforschung N2 - Whilst providing a framework for learning and scientific emancipation, a proposal writing training is confronted with various organisational and didactic challenges, which influence the achievement of the set training objectives. Based on observations made during the workshops for proposal writing organised in Kinshasa, Democratic Republic of Congo, as part of the NMT Programme, the article raises two main questions: (a) How could these challenges be overcome and successfully addressed in the training? (b) What is the level of learning outcomes of the participants at the end of the training? The article shows that the success of the training lays in the relevance of the employed training approaches. The use of a participatory approach encouraged constructive exchanges between participants, trainers, and experts, and enabled all participants to finalise coherent projects to apply for national and international funding. KW - proposal writing KW - participatory didactics KW - national multiplication training Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-493873 SN - 978-3-86956-496-8 SN - 2192-1075 SN - 2192-1083 IS - 5 SP - 145 EP - 165 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Niederkrüger, Matthias A1 - Salb, Christian A1 - Beck, Michael A1 - Hildebrandt, Niko A1 - Löhmannsröben, Hans-Gerd A1 - Marowsky, Gerd T1 - Improvement of a fluorescence immunoassay with a compact diode-pumped solid state laser at 315 nm N2 - We demonstrate the improvement of fluorescence immunoassay (FIA) diagnostics in deploying a newly developed compact diode-pumped solid state (DPSS) laser with emission at 315 nm. The laser is based on the quasi-three-level transition in Nd:YAG at 946 nm. The pulsed operation is either realized by an active Q-switch using an electro-optical device or by introduction of a Cr4+:YAG saturable absorber as passive Q-switch element. By extra-cavity second harmonic generation in different nonlinear crystal media we obtained blue light at 473 nm. Subsequent mixing of the fundamental and the second harmonic in a β-barium-borate crystal provided pulsed emission at 315 nm with up to 20 μJ maximum pulse energy and 17 ns pulse duration. Substitution of a nitrogen laser in a FIA diagnostics system by the DPSS laser succeeded in considerable improvement of the detection limit. Despite significantly lower pulse energies (7 μJ DPSS laser versus 150 μJ nitrogen laser), in preliminary investigations the limit of detection was reduced by a factor of three for a typical FIA. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 016 KW - Immunoassay KW - Fluoreszenz-Resonanz-Energie-Transfer KW - Neodym-YAG-Laser KW - 946 nm KW - 473 nm KW - 315 nm KW - gepulster DPSS Laser KW - sättigbarer Absorber KW - fluorescence immunoassay KW - 946 nm KW - 473 nm KW - 315 nm KW - pulsed DPSS laser Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-10150 ER - TY - JOUR A1 - Czendze, Oskar T1 - In Search of Belonging BT - Galician Jewish Immigrants Between New York and Eastern Europe, 1890–1938 JF - PaRDeS : Journal of the Association for Jewish Studies in Germany JF - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien N2 - More than 200,000 Jews left the Habsburg province of Galicia between 1881 and 1910. No longer living in the places of their childhood, they settled in urban centers, such as in New York’s Lower East Side. In this neighborhood, Galician Jews began to search for new relationships that linked the places they left and the ones where they arrived and settled. By looking at Galicia through the lens of autobiographical writings by former Jewish immigrants who became established residents of New York, this article emphasizes the role of regionalism in the context of transnational conceptions of a new American Jewish self-understanding. It argues that the key to analyzing the evolution of “eastern Europe” as a common place of origin for American Jewry is the constant dialogue between the places of origin and arrival. Specifically, philanthropic efforts during and after the First World War and the proliferation of tourism both enabled these settled immigrants to gradually replace regional notions, such as the idea of Galicia, with a mythical image of eastern Europe to create a sense of community as American Jews. KW - modern Jewish history KW - United States KW - East European Jewish history KW - 19th century KW - 20th century KW - Galicia KW - memory studies KW - travel KW - moderne jüdische Geschichte KW - USA KW - osteuropäisch-jüdische Geschichte KW - 19. Jahrhundert KW - 20. Jahrhundert KW - Galizien KW - Memory studies KW - Reisen Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-532857 SN - 978-3-86956-520-0 SN - 1614-6492 SN - 1862-7684 IS - 27 SP - 69 EP - 83 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Püschel, Gerhard Paul A1 - Hespeling, Ursula A1 - Oppermann, Martin A1 - Dieter, Peter T1 - Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a N2 - Human anaphylatoxin C3a increases glycogenolysis in perfused rat liver. This action is inhibited by prostanoid synthesis inhibitors and prostanoid antagonists. Because prostanoids but not anaphylatoxin C3a can increase glycogenolysis in hepatocytes, it has been proposed that prostanoid formation in nonparenchymal cells represents an important step in the C3a-dependent increase in hepatic glycogenolysis. This study shows that (a) human anaphylatoxin C3a (0.1 to 10 mug/ml) dose-dependently increased prostaglandin D2, thromboxane B, and prostaglandin F2alpha formation in rat liver macrophages (Kupffer cells); (b) the C3a-mediated increase in prostanoid formation was maximal after 2 min and showed tachyphylaxis; and (c) the C3a-elicited prostanoid formation could be inhibited specifically by preincubation of C3a with carboxypeptidase B to remove the essential C-terminal arginine or by preincubation of C3a with Fab fragments of a neutralizing monoclonal antibody. These data support the hypothesis that the C3a-dependent activation of hepatic glycogenolysis is mediated by way of a C3a-induced prostanoid production in Kupffer cells. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 037 KW - lactate output KW - glucose KW - complement KW - flow KW - prostaglandin-f2-alpha Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16716 ER -