TY - GEN A1 - Roelly, Sylvie A1 - Sortais, Michel T1 - Space-time asymptotics of an infinite-dimensional diffusion having a long- range memory N2 - We develop a cluster expansion in space-time for an infinite-dimensional system of interacting diffusions where the drift term of each diffusion depends on the whole past of the trajectory; these interacting diffusions arise when considering the Langevin dynamics of a ferromagnetic system submitted to a disordered external magnetic field. KW - Random Field Ising Model KW - Langevin Dynamics KW - Interacting Diffusion Processes KW - Space-Time Cluster Expansions Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6700 ER - TY - GEN A1 - Roelly, Sylvie A1 - Thieullen, Michèle T1 - Duality formula for the bridges of a Brownian diffusion : application to gradient drifts N2 - In this paper, we consider families of time Markov fields (or reciprocal classes) which have the same bridges as a Brownian diffusion. We characterize each class as the set of solutions of an integration by parts formula on the space of continuous paths C[0; 1]; R-d) Our techniques provide a characterization of gradient diffusions by a duality formula and, in case of reversibility, a generalization of a result of Kolmogorov. KW - reciprocal processes KW - stochastic bridge KW - mixture of bridges KW - integration by parts formula KW - Malliavin calculus KW - entropy KW - time reversal Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6710 ER - TY - GEN A1 - Roelly, Sylvie A1 - Dai Pra, Paolo T1 - An existence result for infinite-dimensional Brownian diffusions with non- regular and non Markovian drift N2 - We prove in this paper an existence result for infinite-dimensional stationary interactive Brownian diffusions. The interaction is supposed to be small in the norm ||.||∞ but otherwise is very general, being possibly non-regular and non-Markovian. Our method consists in using the characterization of such diffusions as space-time Gibbs fields so that we construct them by space-time cluster expansions in the small coupling parameter. KW - infinite-dimensional Brownian diffusion KW - space-time Gibbs field KW - cluster expansion Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6684 ER - TY - GEN A1 - Dosche, Carsten A1 - Mickler, Wulfhard A1 - Löhmannsröben, Hans-Gerd A1 - Agenet, Nicolas A1 - Vollhardt, K. Peter C. T1 - Photoinduced electron transfer in [N]phenylenes N2 - First studies of electron transfer in [N]phenylenes were performed in bimolecular quenching reactions of angular [3]- and triangular [4]phenylene with various electron acceptors. The relation between the quenching rate constants kq and the free energy change of the electron transfer (ΔG0CS ) could be described by the Rehm-Weller equation. From the experimental results, a reorganization energy λ of 0.7 eV was derived. Intramolecular electron transfer reactions were studied in an [N]phenylene bichomophore and a corresponding reference compound. Fluorescence lifetime and quantum yield of the bichromophor display a characteristic dependence on the solvent polarity, whereas the corresponding values of the reference compound remain constant. From the results, a nearly isoenergonic ΔG0CS can be determined. As the triplet quantum yield is nearly independent of the polarity, charge recombination leads to the population of the triplet state. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 23 KW - [N]phenylenes KW - photoinduced electron transfer KW - [N]phenylene dyads Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-12463 ER - TY - GEN A1 - Rheinberg, Falko A1 - Manig, Yvette A1 - Kliegl, Reinhold A1 - Engeser, Stefan A1 - Vollmeyer, Regina T1 - Flow bei der Arbeit, doch Glück in der Freizeit : Zielausrichtung, Flow und Glücksgefühle N2 - Bei N = 101 Arbeitnehmern verschiedener Berufe wurden mit der Experience Sampling Method (ESM) eine Woche lang Daten zum Flow-Erleben, zu Glück/Zufriedenheit und zur Zielausrichtung laufender Aktivitäten erhoben (N = 4603 Messungen). Die Daten wurden mit GLMM-Analysen ausgewertet. Auch bei der jetzt vollständigen Erfassung aller Flow-Komponenten mit der FKS bestätigte sich das „Paradoxon der Arbeit“, wonach während der Arbeit höhere Flow-Werte, aber niedrigere Werte für Glück/Zufriedenheit auftreten als jeweils in der Freizeit. Während der Arbeit waren Aktivitäten häufiger auf die Erreichung von Zielen ausgerichtet als während der Freizeit. Die Zielausrichtung wirkte auf Flow vs. Glück/Zufriedenheit signifikant verschieden. Während der Arbeit hat die Zielausrichtung auf Flow einen stark positiven Effekt, auf Glück/Zufriedenheit jedoch nicht. Im Freizeitbereich war der Effekt von Zielausrichtung auf Glück/Zufriedenheit sogar negativ. Das „Paradoxon der Arbeit“ lässt sich partiell als Effekt der Zielausrichtung verstehen. N2 - For a week, data of N =101 employees with different professions was collected with the Experience Sampling Method (N = 4603 measurements). These data included flow-experience, happiness/satisfaction and goal adjustment of current activities. The data were analysed with GLMM. Flow-experience was measured with all components (FKS) and they confirmed the "paradox of work" (i.e., flow-scores are higher during work but scores for happiness/satisfaction are higher during spare time). During work, participants activities were more often directed towards reaching a goal. The effects of goal adjustment on flow vs. happiness/satisfaction differed significantly. During work goal adjustment had a strong positive effect on flow, but not on happiness/satisfaction. During leisure time goal adjustment had even a negative effect on happiness/satisfaction but a positive on flow. The "paradox of work" could be partially attributed to the stronger goal adjustment during work. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - paper 036 KW - Flow-Erleben KW - Ziele KW - Glück/Zufriedenheit KW - Arbeit KW - Freizeit KW - Flow-experience KW - goals KW - happiness/satisfaction KW - work KW - leisure time Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-19740 ER - TY - GEN A1 - Steinfath, Matthias A1 - Gärtner, Tanja A1 - Lisec, Jan A1 - Meyer, Rhonda C. A1 - Altmann, Thomas A1 - Willmitzer, Lothar A1 - Selbig, Joachim T1 - Prediction of hybrid biomass in Arabidopsis thaliana by selected parental SNP and metabolic markers T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - A recombinant inbred line (RIL) population, derived from two Arabidopsis thaliana accessions, and the corresponding testcrosses with these two original accessions were used for the development and validation of machine learning models to predict the biomass of hybrids. Genetic and metabolic information of the RILs served as predictors. Feature selection reduced the number of variables (genetic and metabolic markers) in the models by more than 80% without impairing the predictive power. Thus, potential biomarkers have been revealed. Metabolites were shown to bear information on inherited macroscopic phenotypes. This proof of concept could be interesting for breeders. The example population exhibits substantial mid-parent biomass heterosis. The results of feature selection could therefore be used to shed light on the origin of heterosis. In this respect, mainly dominance effects were detected. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1324 KW - Quantitative Trait Locus KW - feature selection KW - Partial Little Square KW - recombinant inbred line KW - Quantitative Trait Locus analysis Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431115 SN - 1866-8372 IS - 1324 ER - TY - GEN A1 - Thonig, Richard A1 - Del Rio, Pablo A1 - Kiefer, Christoph A1 - Lazaro Touza, Lara A1 - Escribano, Gonzalo A1 - Lechon, Yolanda A1 - Spaeth, Leonhard A1 - Wolf, Ingo A1 - Lilliestam, Johan T1 - Does ideology influence the ambition level of climate and renewable energy policy? BT - Insights from four European countries T2 - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe N2 - We investigate whether political ideology has an observable effect on decarbonization ambition, renewable power aims, and preferences for power system balancing technologies in four European countries. Based on the Energy Logics framework, we identify ideologically different transition strategies (state-centered, market-centered, grassroots-centered) contained in government policies and opposition party programs valid in 2019. We compare these policies and programs with citizen poll data. We find that ideology has a small effect: governments and political parties across the spectrum have similar, and relatively ambitious, decarbonization and renewables targets. This mirrors citizens' strong support for ambitious action regardless of their ideological self-description. However, whereas political positions on phasing out fossil fuel power are clear across the policy space, positions on phasing in new flexibility options to balance intermittent renewables are vague or non-existent. As parties and citizens agree on strong climate and renewable power aims, the policy ambition is likely to remain high, even if governments change. T3 - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 161 KW - political ideology KW - climate policy KW - energy policy KW - europe KW - european KW - Union KW - renewable energy KW - flexibility Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-577981 SN - 1867-5808 IS - 1 ER - TY - GEN A1 - Gronau, Norbert A1 - Wildemann, Horst A1 - Zäh, Michael F. T1 - Entwicklung und Betrieb wandlungsfähiger Auftragsabwicklungssysteme T1 - Development and application of adaptive enterprise resource planning systems N2 - Mittelständische Industrieunternehmen setzen für ihre betrieblichen Abläufe Planungs- und Ausführungssysteme ein. Aufgrund der Turbulenzen auf Absatz- und Beschaffungsmärkten kann die Wirtschaftlichkeit und Wettbewerbsfähigkeit dieser Unternehmen nur durch permanente Anpassungen der Organisationsstrukturen und -abläufe erfolgen. In der Praxis zeigt sich eine unzureichende technologische Anpassungsfähigkeit der heute eingesetzten Standardsoftwaresysteme. Diese lassen zwar während der Einführungsphase vielfältige Konfigurationsmöglichkeiten zu, Veränderungen im laufenden Betrieb sind aber meist nur mit großem Aufwand möglich. Hier sind die Softwarehersteller in Zukunft zunehmend gefordert, wandlungsfähige Auftragsabwicklungssysteme zu entwickeln. Über die Entwicklungsphase (Build-Time) hinaus muss auch parallel zur Betriebsphase (Run-Time) der technische Fortschritt aufgrund von geänderten Anforderungen durch entsprechende Softwarereleases synchronisiert werden. N2 - Development and application of adaptive enterprise resource planning systems: Medium-sized industrial enterprises apply resource planning systems for their business processes. Changing markets require permanent adaptation of these enterprises’ organisational structures and processes to ensure their efficiency and their competitiveness. However, currently applied standard software systems have proven to be insufficiently adaptable. They allow multiple configuration options during implementation and setup, but it is hardly possible to perform configuration changes during the application phase. Therefore software developers will have to focus on adaptable enterprise resource planning systems in future. Beyond the development phase (build time) technological progress caused by changing requirements also has to be synchronised simultaneously by current software releases during the application phase (run time). -------- © GITO mbH Berlin KW - Auftragsabwicklung KW - Industrieunternehmen KW - Wandlungsfähigkeit KW - Auftragsabwicklungssysteme KW - Regelkreismechanismus KW - adaptability KW - enterprise resource planning systems KW - control loop mechanism Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6791 ER - TY - GEN A1 - Omane, Paul Okyere A1 - Höhle, Barbara T1 - Acquiring Syntactic Variability: The Production of Wh-Questions in Children and Adults Speaking Akan T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - This paper investigates the predictions of the Derivational Complexity Hypothesis by studying the acquisition of wh-questions in 4- and 5-year-old Akan-speaking children in an experimental approach using an elicited production and an elicited imitation task. Akan has two types of wh-question structures (wh-in-situ and wh-ex-situ questions), which allows an investigation of children’s acquisition of these two question structures and their preferences for one or the other. Our results show that adults prefer to use wh-ex-situ questions over wh-in-situ questions. The results from the children show that both age groups have the two question structures in their linguistic repertoire. However, they differ in their preferences in usage in the elicited production task: while the 5-year-olds preferred the wh-in-situ structure over the wh-ex-situ structure, the 4-year-olds showed a selective preference for the wh-in-situ structure in who-questions. These findings suggest a developmental change in wh-question preferences in Akan-learning children between 4 and 5 years of age with a so far unobserved u-shaped developmental pattern. In the elicited imitation task, all groups showed a strong tendency to maintain the structure of in-situ and ex-situ questions in repeating grammatical questions. When repairing ungrammatical ex-situ questions, structural changes to grammatical in-situ questions were hardly observed but the insertion of missing morphemes while keeping the ex-situ structure. Together, our findings provide only partial support for the Derivational Complexity Hypothesis. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 738 KW - Akan KW - wh-questions KW - wh-in-situ KW - wh-ex-situ KW - derivational complexity KW - language acquisition Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-536867 SN - 1866-8364 SP - 1 EP - 15 ER - TY - GEN A1 - Puschmann, Anne-Katrin A1 - Lin, I-Chiao A1 - Wippert, Pia-Maria T1 - Sustainability of a motor control exercise intervention BT - Analysis of long-term effects in a low back pain study T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Development of chronic pain after a low back pain episode is associated with increased pain sensitivity, altered pain processing mechanisms and the influence of psychosocial factors. Although there is some evidence that multimodal therapy (such as behavioral or motor control therapy) may be an important therapeutic strategy, its long-term effect on pain reduction and psychosocial load is still unclear. Prospective longitudinal designs providing information about the extent of such possible long-term effects are missing. This study aims to investigate the long-term effects of a homebased uni- and multidisciplinary motor control exercise program on low back pain intensity, disability and psychosocial variables. 14 months after completion of a multicenter study comparing uni- and multidisciplinary exercise interventions, a sample of one study center (n = 154) was assessed once more. Participants filled in questionnaires regarding their low back pain symptoms (characteristic pain intensity and related disability), stress and vital exhaustion (short version of the Maastricht Vital Exhaustion Questionnaire), anxiety and depression experiences (the Hospital and Anxiety Depression Scale), and pain-related cognitions (the Fear Avoidance Beliefs Questionnaire). Repeated measures mixed ANCOVAs were calculated to determine the long-term effects of the interventions on characteristic pain intensity and disability as well as on the psychosocial variables. Fifty four percent of the sub-sample responded to the questionnaires (n = 84). Longitudinal analyses revealed a significant long-term effect of the exercise intervention on pain disability. The multidisciplinary group missed statistical significance yet showed a medium sized long-term effect. The groups did not differ in their changes of the psychosocial variables of interest. There was evidence of long-term effects of the interventions on pain-related disability, but there was no effect on the other variables of interest. This may be partially explained by participant's low comorbidities at baseline. Results are important regarding costless homebased alternatives for back pain patients and prevention tasks. Furthermore, this study closes the gap of missing long-term effect analysis in this field. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 752 KW - MiSpEx KW - low back pain KW - long-term effects KW - multidisciplinary intervention KW - sustainability Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-544083 SN - 1866-8364 SP - 1 EP - 8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Stone, Kate A1 - Nicenboim, Bruno A1 - Vasishth, Shravan A1 - Rösler, Frank T1 - Understanding the effects of constraint and predictability in ERP T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Intuitively, strongly constraining contexts should lead to stronger probabilistic representations of sentences in memory. Encountering unexpected words could therefore be expected to trigger costlier shifts in these representations than expected words. However, psycholinguistic measures commonly used to study probabilistic processing, such as the N400 event-related potential (ERP) component, are sensitive to word predictability but not to contextual constraint. Some research suggests that constraint-related processing cost may be measurable via an ERP positivity following the N400, known as the anterior post-N400 positivity (PNP). The PNP is argued to reflect update of a sentence representation and to be distinct from the posterior P600, which reflects conflict detection and reanalysis. However, constraint-related PNP findings are inconsistent. We sought to conceptually replicate Federmeier et al. (2007) and Kuperberg et al. (2020), who observed that the PNP, but not the N400 or the P600, was affected by constraint at unexpected but plausible words. Using a pre-registered design and statistical approach maximising power, we demonstrated a dissociated effect of predictability and constraint: strong evidence for predictability but not constraint in the N400 window, and strong evidence for constraint but not predictability in the later window. However, the constraint effect was consistent with a P600 and not a PNP, suggesting increased conflict between a strong representation and unexpected input rather than greater update of the representation. We conclude that either a simple strong/weak constraint design is not always sufficient to elicit the PNP, or that previous PNP constraint findings could be an artifact of smaller sample size. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 829 KW - N400 KW - anterior PNP KW - posterior P600 KW - probabilistic processing KW - constraint KW - predictability KW - entropy Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-587594 SN - 1866-8364 IS - 829 ER - TY - GEN A1 - Kotthoff, Lisa A1 - Lisec, Jan A1 - Schwerdtle, Tanja A1 - Koch, Matthias T1 - Prediction of transformation products of monensin by electrochemistry compared to microsomal assay and hydrolysis T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The knowledge of transformation pathways and identification of transformation products (TPs) of veterinary drugs is important for animal health, food, and environmental matters. The active agent Monensin (MON) belongs to the ionophore antibiotics and is widely used as a veterinary drug against coccidiosis in broiler farming. However, no electrochemically (EC) generated TPs of MON have been described so far. In this study, the online coupling of EC and mass spectrometry (MS) was used for the generation of oxidative TPs. EC-conditions were optimized with respect to working electrode material, solvent, modifier, and potential polarity. Subsequent LC/HRMS (liquid+ chromatography/high resolution mass spectrometry) and MS/MS experiments were performed to identify the structures of derived TPs by a suspected target analysis. The obtained EC-results were compared to TPs observed in metabolism tests with microsomes and hydrolysis experiments of MON. Five previously undescribed TPs of MON were identified in our EC/MS based study and one TP, which was already known from literature and found by a microsomal assay, could be confirmed. Two and three further TPs were found as products in microsomal tests and following hydrolysis, respectively. We found decarboxylation, O-demethylation and acid-catalyzed ring-opening reactions to be the major mechanisms of MON transformation T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1340 KW - transformation products KW - monensin KW - veterinary drugs KW - electrochemistry KW - hydrolysis KW - LC/HRMS Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473262 SN - 1866-8372 IS - 1340 ER - TY - GEN A1 - Roelly, Sylvie A1 - Dereudre, David T1 - Propagation of Gibbsiannes for infinite-dimensional gradient Brownian diffusions N2 - We study the (strong-)Gibbsian character on R Z d of the law at time t of an infinitedimensional gradient Brownian diffusion , when the initial distribution is Gibbsian. KW - infinite-dimensional Brownian diffusion KW - Gibbs measure KW - cluster expansion Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6918 ER - TY - GEN A1 - Roelly, Sylvie A1 - Dereudre, David T1 - On Gibbsianness of infinite-dimensional diffusions N2 - The authors analyse different Gibbsian properties of interactive Brownian diffusions X indexed by the d-dimensional lattice. In the first part of the paper, these processes are characterized as Gibbs states on path spaces. In the second part of the paper, they study the Gibbsian character on R^{Z^d} of the law at time t of the infinite-dimensional diffusion X(t), when the initial law is Gibbsian. AMS Classifications: 60G15 , 60G60 , 60H10 , 60J60 KW - infinite-dimensional Brownian diffusion KW - Gibbs field KW - cluster expansion Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6692 ER - TY - GEN A1 - Stiegler, Jonas A1 - Lins, Alisa A1 - Dammhahn, Melanie A1 - Kramer-Schadt, Stephanie A1 - Ortmann, Sylvia A1 - Blaum, Niels T1 - Personality drives activity and space use in a mammalian herbivore T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background Animal personality has emerged as a key concept in behavioral ecology. While many studies have demonstrated the influence of personality traits on behavioral patterns, its quantification, especially in wild animal populations, remains a challenge. Only a few studies have established a link between personality and recurring movements within home ranges, although these small-scale movements are of key importance for identifying ecological interactions and forming individual niches. In this regard, differences in space use among individuals might reflect different exploration styles between behavioral types along the shy-bold continuum. Methods We assessed among-individual differences in behavior in the European hare (Lepus europaeus), a characteristic mammalian herbivore in agricultural landscapes using a standardized box emergence test for captive and wild hares. We determined an individuals’ degree of boldness by measuring the latencies of behavioral responses in repeated emergence tests in captivity. During capture events of wild hares, we conducted a single emergence test and recorded behavioral responses proven to be stable over time in captive hares. Applying repeated novel environment tests in a near-natural enclosure, we further quantified aspects of exploration and activity in captive hares. Finally, we investigated whether and how this among-individual behavioral variation is related to general activity and space use in a wild hare population. Wild and captive hares were treated similarly and GPS-collared with internal accelerometers prior to release to the wild or the outdoor enclosure, respectively. General activity was quantified as overall dynamic body acceleration (ODBA) obtained from accelerometers. Finally, we tested whether boldness explained variation in (i) ODBA in both settings and (ii) variation in home ranges and core areas across different time scales of GPS-collared hares in a wild population. Results We found three behavioral responses to be consistent over time in captive hares. ODBA was positively related to boldness (i.e., short latencies to make first contact with the new environment) in both captive and wild hares. Space use in wild hares also varied with boldness, with shy individuals having smaller core areas and larger home ranges than bold conspecifics (yet in some of the parameter space, this association was just marginally significant). Conclusions Against our prediction, shy individuals occupied relatively large home ranges but with small core areas. We suggest that this space use pattern is due to them avoiding risky, and energy-demanding competition for valuable resources. Carefully validated, activity measurements (ODBA) from accelerometers provide a valuable tool to quantify aspects of animal personality along the shy-bold continuum remotely. Without directly observing—and possibly disturbing—focal individuals, this approach allows measuring variability in animal personality, especially in species that are difficult to assess with experiments. Considering that accelerometers are often already built into GPS units, we recommend activating them at least during the initial days of tracking to estimate individual variation in general activity and, if possible, match them with a simple novelty experiment. Furthermore, information on individual behavioral types will help to facilitate mechanistic understanding of processes that drive spatial and ecological dynamics in heterogeneous landscapes. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1299 KW - Animal personality KW - Movement ecology KW - Inter-individual differences KW - ODBA KW - Energy expenditure KW - European hare Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-577327 SN - 1866-8372 SP - 1 EP - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Rancan, Fiorenza A1 - Volkmann, Hildburg A1 - Giulbudagian, Michael A1 - Schumacher, Fabian A1 - Stanko, Jessica Isolde A1 - Kleuser, Burkhard A1 - Blume-Peytavi, Ulrike A1 - Calderón, Marcelo A1 - Vogt, Annika T1 - Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the skin penetration of tacrolimus formulated in tNGs with a commercial 0.1% tacrolimus ointment. The penetration of the drug was investigated in ex vivo abdominal and breast skin, while different methods for skin barrier disruption were investigated to improve skin permeability or simulate inflammatory conditions with compromised skin barrier. The amount of penetrated tacrolimus was measured in skin extracts by liquid chromatography tandem-mass spectrometry (LC-MS/MS), whereas the inflammatory markers IL-6 and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA). Higher amounts of tacrolimus penetrated in breast as compared to abdominal skin or in barrier-disrupted as compared to intact skin, confirming that the stratum corneum is the main barrier for tacrolimus skin penetration. The anti-proliferative effect of the penetrated drug was measured in skin tissue/Jurkat cells co-cultures. Interestingly, tNGs exhibited similar anti-proliferative effects as the 0.1% tacrolimus ointment. We conclude that polyglycerol-based nanogels represent an interesting alternative to paraffin-based formulations for the treatment of inflammatory skin conditions. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1339 KW - tacrolimus formulation KW - nanogels KW - skin penetration KW - drug delivery KW - human excised skin KW - Jurkat cells Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473270 SN - 1866-8372 IS - 1339 ER - TY - GEN A1 - Trilcke, Peer A1 - Parr, Rolf A1 - D'Aprile, Iwan-Michelangelo A1 - Kraus, Hans-Christof A1 - Blomqvist, Clarissa A1 - McGillen, Petra S. A1 - Aus der Au, Carmen A1 - Phillips, Alexander Robert A1 - Helmer, Debora A1 - Singer, Rüdiger A1 - Görner, Rüdiger A1 - Berbig, Roland A1 - Rose, Dirk A1 - Wilhelms, Kerstin A1 - Krause, Marcus A1 - Hehle, Christine A1 - Gretz, Daniela A1 - Gfrereis, Heike A1 - Lepp, Nicola A1 - Morlok, Franziska A1 - Haut, Gideon A1 - Brechenmacher, Thomas A1 - Stauffer, Isabelle A1 - Lyon, John B. A1 - Bachmann, Vera A1 - Ewert, Michael A1 - Immer, Nikolas A1 - Vedder, Ulrike A1 - Fischer, Hubertus A1 - Becker, Sabina A1 - Wegmann, Christoph A1 - Möller, Klaus-Peter A1 - Schneider, Ulrike A1 - Waszynski, Alexander A1 - Wedel, Michael A1 - Brehm, David A1 - Wolpert, Georg ED - Trilcke, Peer T1 - Fontanes Medien T2 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe N2 - Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen. Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 178 KW - Fontane, Theodor KW - Gesellschaft KW - Medialisierung KW - Presse Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-574079 SN - 1866-8380 IS - 178 ER - TY - GEN A1 - Clegg, Mark R. A1 - Wacker, Alexander A1 - Spijkerman, Elly T1 - Phenotypic Diversity and Plasticity of Photoresponse Across an Environmentally Contrasting Family of Phytoflagellates T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Organisms often employ ecophysiological strategies to exploit environmental conditions and ensure bio-energetic success. However, the many complexities involved in the differential expression and flexibility of these strategies are rarely fully understood. Therefore, for the first time, using a three-part cross-disciplinary laboratory experimental analysis, we investigated the diversity and plasticity of photoresponsive traits employed by one family of environmentally contrasting, ecologically important phytoflagellates. The results demonstrated an extensive inter-species phenotypic diversity of behavioural, physiological, and compositional photoresponse across the Chlamydomonadaceae, and a multifaceted intra-species phenotypic plasticity, involving a broad range of beneficial photoacclimation strategies, often attributable to environmental predisposition and phylogenetic differentiation. Deceptively diverse and sophisticated strong (population and individual cell) behavioural photoresponses were observed, with divergence from a general preference for low light (and flexibility) dictated by intra-familial differences in typical habitat (salinity and trophy) and phylogeny. Notably, contrasting lower, narrow, and flexible compared with higher, broad, and stable preferences were observed in freshwater vs. brackish and marine species. Complex diversity and plasticity in physiological and compositional photoresponses were also discovered. Metabolic characteristics (such as growth rates, respiratory costs and photosynthetic capacity, efficiency, compensation and saturation points) varied elaborately with species, typical habitat (often varying more in eutrophic species, such as Chlamydomonas reinhardtii), and culture irradiance (adjusting to optimise energy acquisition and suggesting some propensity for low light). Considerable variations in intracellular pigment and biochemical composition were also recorded. Photosynthetic and accessory pigments (such as chlorophyll a, xanthophyll-cycle components, chlorophyll a:b and chlorophyll a:carotenoid ratios, fatty acid content and saturation ratios) varied with phylogeny and typical habitat (to attune photosystem ratios in different trophic conditions and to optimise shade adaptation, photoprotection, and thylakoid architecture, particularly in freshwater environments), and changed with irradiance (as reaction and harvesting centres adjusted to modulate absorption and quantum yield). The complex, concomitant nature of the results also advocated an integrative approach in future investigations. Overall, these nuanced, diverse, and flexible photoresponsive traits will greatly contribute to the functional ecology of these organisms, addressing environmental heterogeneity and potentially shaping individual fitness, spatial and temporal distribution, prevalence, and ecosystem dynamics. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1219 KW - photoresponse KW - behaviour KW - physiology KW - composition KW - photosynthesis KW - acclimation KW - Chlamydomonas KW - ecophysiology Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-536174 SN - 1866-8372 IS - 1219 ER - TY - GEN A1 - Ye, Fangyuan A1 - Zhang, Shuo A1 - Warby, Jonathan A1 - Wu, Jiawei A1 - Gutierrez-Partida, Emilio A1 - Lang, Felix A1 - Shah, Sahil A1 - Saglamkaya, Elifnaz A1 - Sun, Bowen A1 - Zu, Fengshuo A1 - Shoaee, Safa A1 - Wang, Haifeng A1 - Stiller, Burkhard A1 - Neher, Dieter A1 - Zhu, Wei-Hong A1 - Stolterfoht, Martin A1 - Wu, Yongzhen T1 - Overcoming C₆₀-induced interfacial recombination in inverted perovskite solar cells by electron-transporting carborane T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C₆₀ interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C₆₀ interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23% with a low non-radiative voltage loss of 110 mV, and retain >97% of the initial efficiency after 400 h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1317 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-587705 SN - 1866-8372 IS - 1317 ER -