TY - JOUR A1 - Tarkhanov, Nikolai Nikolaevich T1 - Deformation quantization and boundary value problems JF - International journal of geometric methods in modern physics : differential geometery, algebraic geometery, global analysis & topology N2 - We describe a natural construction of deformation quantization on a compact symplectic manifold with boundary. On the algebra of quantum observables a trace functional is defined which as usual annihilates the commutators. This gives rise to an index as the trace of the unity element. We formulate the index theorem as a conjecture and examine it by the classical harmonic oscillator. KW - Symplectic manifold KW - star product KW - trace KW - index Y1 - 2016 U6 - https://doi.org/10.1142/S0219887816500079 SN - 0219-8878 SN - 1793-6977 VL - 13 SP - 176 EP - 195 PB - World Scientific CY - Singapore ER - TY - INPR A1 - Tarkhanov, Nikolai Nikolaevich T1 - On the root functions of general elliptic boundary value problems N2 - We consider a boundary value problem for an elliptic differential operator of order 2m in a domain D ⊂ n. The boundary of D is smooth outside a finite number of conical points, and the Lopatinskii condition is fulfilled on the smooth part of δD. The corresponding spaces are weighted Sobolev spaces H(up s,Υ)(D), and this allows one to define ellipticity of weight Υ for the problem. The resolvent of the problem is assumed to possess rays of minimal growth. The main result says that if there are rays of minimal growth with angles between neighbouring rays not exceeding π(Υ + 2m)/n, then the root functions of the problem are complete in L²(D). In the case of second order elliptic equations the results remain true for all domains with Lipschitz boundary. T3 - Preprint - (2005) 07a Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-29822 ER - TY - INPR A1 - Tarkhanov, Nikolai Nikolaevich T1 - Unitary solutions of partial differential equations N2 - We give an explicit construction of a fundamental solution for an arbitrary non-degenerate partial differential equation with smooth coefficients. T3 - Preprint - (2005) 09 KW - fundamental solution KW - geometric optics approximation Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-29852 ER - TY - INPR A1 - Tarkhanov, Nikolai Nikolaevich T1 - A fixed point formula in one complex variable N2 - We show a Lefschetz fixed point formula for holomorphic functions in a bounded domain D with smooth boundary in the complex plane. To introduce the Lefschetz number for a holomorphic map of D, we make use of the Bergman kernal of this domain. The Lefschetz number is proved to be the sum of usual contributions of fixed points of the map in D and contributions of boundary fixed points, these latter being different for attracting and repulsing fixed points. T3 - Preprint - (2003) 01 Y1 - 2003 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26495 ER - TY - BOOK A1 - Tarkhanov, Nikolai Nikolaevich A1 - Vasilevski, Nikolai T1 - Microlocal analysis of the Bochner-Martinelli Integral T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2005 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Tarkhanov, Nikolai Nikolaevich A1 - Vasilevski, Nikolai T1 - Microlocal analysis of the Bochner-Martinelli integral N2 - In order to characterise the C*-algebra generated by the singular Bochner-Martinelli integral over a smooth closed hypersurfaces in Cn, we compute its principal symbol. We show then that the Szegö projection belongs to the strong closure of the algebra generated by the singular Bochner-Martinelli integral. T3 - Preprint - (2005) 25 Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30012 ER - TY - INPR A1 - Tarkhanov, Nikolai Nikolaevich A1 - Wallenta, Daniel T1 - The Lefschetz number of sequences of trace class curvature N2 - For a sequence of Hilbert spaces and continuous linear operators the curvature is defined to be the composition of any two consecutive operators. This is modeled on the de Rham resolution of a connection on a module over an algebra. Of particular interest are those sequences for which the curvature is "small" at each step, e.g., belongs to a fixed operator ideal. In this context we elaborate the theory of Fredholm sequences and show how to introduce the Lefschetz number. T3 - Preprints des Instituts für Mathematik der Universität Potsdam - 1 (2012) 3 KW - Perturbed complexes KW - curvature KW - Lefschetz number Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-56969 ER - TY - INPR A1 - Tepoyan, Liparit T1 - Degenerated operator equations of higher order N2 - Content: 1 Introduction 2 The one-dimensional case 2.1 The space Wm sub (α) 2.2 Self-adjoint Equation 2.3 Non-selfadjoint Equation 3 Operator Equation T3 - Preprint - (2000) 23 Y1 - 2000 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-25888 ER - TY - INPR A1 - Tepoyan, Liparit T1 - The mixed problem for a degenerate operator equation N2 - We consider a mixed problem for a degenerate differentialoperator equation of higher order. We establish some embedding theorems in weighted Sobolev spaces and show existence and uniqueness of the generalized solution of this problem. We also give a description of the spectrum for the corresponding operator. T3 - Preprint - (2008) 06 Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30334 ER - TY - JOUR A1 - Thiem, Wolfgang T1 - Didaktik der Erziehungswissenschaft (Pädagogik) - ein weites Feld? Y1 - 1996 ER - TY - JOUR A1 - Tillmann, Alexander A1 - Krömker, Detlef A1 - Horn, Florian A1 - Gattinger, Thorsten T1 - Analysing & Predicting Students Performance in an Introductory Computer Science Course JF - Commentarii informaticae didacticae N2 - Students of computer science studies enter university education with very different competencies, experience and knowledge. 145 datasets collected of freshmen computer science students by learning management systems in relation to exam outcomes and learning dispositions data (e. g. student dispositions, previous experiences and attitudes measured through self-reported surveys) has been exploited to identify indicators as predictors of academic success and hence make effective interventions to deal with an extremely heterogeneous group of students. KW - Blended learning KW - heterogeneity KW - Learning analytics KW - Learning dispositions KW - Dispositional learning analytics KW - Formative assessment Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416307 IS - 12 SP - 29 EP - 45 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - THES A1 - Tinpun, Kittisak T1 - Relative rank of infinite full transformation semigroups with restricted range Y1 - 2019 ER - TY - JOUR A1 - Tinpun, Kittisak A1 - Koppitz, Jörg T1 - Generating sets of infinite full transformation semigroups with restricted range JF - Acta scientiarum mathematicarum N2 - In the present paper, we consider minimal generating sets of infinite full transformation semigroups with restricted range modulo specific subsets. In particular, we determine relative ranks. KW - generating sets KW - transformation semigroups KW - restricted range KW - relative ranks Y1 - 2016 U6 - https://doi.org/10.14232/actasm-015-502-4 SN - 0001-6969 VL - 82 SP - 55 EP - 63 PB - Institutum Bolyaianum Universitatis Szegediensis CY - Szeged ER - TY - THES A1 - Trappmann, Henryk T1 - Arborescent numbers : higher arithmetic operations and division trees T1 - Baumartige Zahlen : höhere arithmetische Operationen und Divisionsbäume N2 - The overall program "arborescent numbers" is to similarly perform the constructions from the natural numbers (N) to the positive fractional numbers (Q+) to positive real numbers (R+) beginning with (specific) binary trees instead of natural numbers. N can be regarded as the associative binary trees. The binary trees B and the left-commutative binary trees P allow the hassle-free definition of arbitrary high arithmetic operations (hyper ... hyperpowers). To construct the division trees the algebraic structure "coppice" is introduced which is a group with an addition over which the multiplication is right-distributive. Q+ is the initial associative coppice. The present work accomplishes one step in the program "arborescent numbers". That is the construction of the arborescent equivalent(s) of the positive fractional numbers. These equivalents are the "division binary trees" and the "fractional trees". A representation with decidable word problem for each of them is given. The set of functions f:R1->R1 generated from identity by taking powers is isomorphic to P and can be embedded into a coppice by taking inverses. N2 - Baumartige Zahlen und höhere arithmetische Operationen Von Schülern und Laienmathematikern wird oft die Frage gestellt, warum nach den Operationen Addition (1. Stufe), Multiplikation (2. Stufe), Potenzieren (3. Stufe) keine Operationen der 4. oder höheren Stufen betrachtet werden. Jede Operation der nächsthöheren Stufe ist die Wiederholung der vorhergehenden Operation, z.B. n * x = x + x + ... + x x^n = x * x * ... * x Das offensichtliche Problem mit der Wiederholung des Potenzierens besteht darin, dass das Potenzieren nicht assoziativ ist und es somit mehrere Klammerungsmöglichkeiten für die Wiederholung dieser Operation gibt. Wählt man eine spezifische Klammerungsmöglichkeit aus, z.B. x^^n = (x^(x^(x^(......)))), gibt es jedoch wieder verschiedene Möglichkeiten, diese Operation auf rationale oder reelle n fortzusetzen. In der Tat kann man im Internet verschiedene solcher Fortsetzungen beschrieben finden und keine scheint besonders ausgezeichnet zu sein. Das ganze Dilemma der verschiedenen Klammerungen kann man jedoch überwinden, in dem man den Zahlenbereich abstrakter macht. So dass statt nur der Anzahl auch eine Klammerungsstruktur in einer Zahl kodiert wird. Die ganz natürliche Verallgemeinerung der natürlichen Zahlen in dieser Hinsicht sind die Binärbäume. Und in der Tat lassen sich die 4. und höhere Operationen in einer eindeutigen Weise auf den Binärbäumen erklären. Vielmehr stellt sich sogar heraus, dass die Binärbäume zu viel Information mit sich tragen, wenn es nur darum geht, die höheren Operationen zu definieren. Es gibt eine Spezialisierung der Binärbäume, die aber allgemeiner als die natürlichen Zahlen (die die assoziative Spezialisierung der Binärbäume sind) ist, und die die passende Informationsmenge zur Definition der höheren Operationen kodiert. Dies sind die so genannten linkskommutativen Binärbäume. Es stellt sich heraus, dass die (linkskommutativen) Binärbäume viele Eigenschaften der natürlichen Zahlen teilen, so z.B. die Assoziativität der Multiplikation (die Operation der 2. Stufe) und eine eindeutige Primzahlzerlegung. Dies motiviert die Frage, ob man die Erweiterungskonstruktionen der Zahlen: „natürliche Zahlen zu gebrochenen Zahlen“ (macht die Multiplikation umkehrbar) „gebrochene Zahlen zu positiven reellen Zahlen“ (macht das Potenzieren umkehrbar und erlaubt Grenzwertbildung) auch ausgehend von (linkskommutativen) Binärbäumen vornehmen kann. In der vorliegenden Arbeit wird (neben unzähligen anderen Resultaten) gezeigt, dass die Zahlenbereichserweiterung „natürliche Zahlen zu gebrochenen Zahlen“ auch analog für (linkskommutative) Binärbäume möglich ist. Das Ergebnis dieser Konstruktion sind die Divisionsbinärbäume (bzw. die gebrochenen Bäume). Letztere lassen sich unerwartet in der Form von Brüchen darstellen, sind jedoch als Verallgemeinerung der gebrochenen Zahlen sehr viel komplexer als dieser. (Das kann man live nachprüfen mit dem dafür erstellten Online-Rechner für gebrochene Bäume (auf englisch): http://math.eretrandre.org/cgi-bin/ftc/ftc.pl ) Damit wird ein Programm „baumartige Zahlen“ gestartet, indem es darum geht, auch die Erweiterung „gebrochene Zahlen zu positiven reellen Zahlen“ für die Divisionsbinärbäume (bzw. die gebrochenen Bäume) durchzuführen, wobei die höheren Operationen auf dieser Erweiterung definiert werden könnten und umkehrbar sein müssten. Ob dies wirklich möglich ist, ist derzeit unklar (neben diversen anderen direkt aus der Dissertation sich ergebenden Fragen) und eröffnet damit ein enorm umfangreiches Feld für weitere Forschungen. KW - Tetration KW - höhere Operationen KW - strukturierte Zahlen KW - Divisionsbäume KW - tetration KW - higher operations KW - structured numbers KW - division trees Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-15247 ER - TY - THES A1 - Trump, Stephanie Sonja T1 - Mathematik in der Physik der Sekundarstufe II!? BT - Eine Benennung notwendiger mathematischer Fertigkeiten für einen flexiblen Umgang mit Mathematik beim Lösen physikalisch-mathematischer Probleme im Rahmen der Schul- und Hochschulbildung sowie eine systematische Analyse zur notwendigen Mathematik in der Physik der Sekundarstufe II Y1 - 2015 ER - TY - THES A1 - Tschisgale, Paul T1 - Introduction to the Glauber dynamics for the Curie-Weiss Potts model N2 - This thesis aims at presenting in an organized fashion the required basics to understand the Glauber dynamics as a way of simulating configurations according to the Gibbs distribution of the Curie-Weiss Potts model. Therefore, essential aspects of discrete-time Markov chains on a finite state space are examined, especially their convergence behavior and related mixing times. Furthermore, special emphasis is placed on a consistent and comprehensive presentation of the Curie-Weiss Potts model and its analysis. Finally, the Glauber dynamics is studied in general and applied afterwards in an exemplary way to the Curie-Weiss model as well as the Curie-Weiss Potts model. The associated considerations are supplemented with two computer simulations aiming to show the cutoff phenomenon and the temperature dependence of the convergence behavior. N2 - Die vorliegende Arbeit verfolgt das Ziel, die erforderlichen Grundlagen für das Verständnis der Glauber Dynamik auf organisierte Art und Weise darzustellen. Die Glauber Dynamik stellt eine Möglichkeit der Simulation von Konfigurationen der Gibbs Verteilung des Curie-Weiss Potts Modells dar. Es werden zunächst die zum Verständnis notwendigen Grundlagen von endlichen Markov-Ketten in diskreter Zeit beleuchtet, insbesondere ihr Konvergenzverhalten und die damit verbundene Mischzeit. Darüber hinaus legt diese Arbeit einen Schwerpunkt auf eine konsistente sowie verständliche Darbietung und Analyse des Curie-Weiss Potts Modells. Schließlich wird explizit die Glauber Dynamik betrachtet und anschließend exemplarisch auf das Curie-Weiss Modell und auf das Curie-Weiss Potts Modell angewandt. Die dazugehörigen Betrachtungen werden durch zwei Computersimulationen ergänzt, welche darauf abzielen, das Cutoff-Phänomen sowie die Temperaturabhängigkeit des Konvergenzverhaltens darzustellen bzw. zu verdeutlichen. T2 - Einführung in die Glauber Dynamik des Curie-Weiss Potts Modells KW - Glauber Dynamics KW - Curie-Weiss Potts Model KW - Mixing Times KW - MCMC KW - Glauber Dynamik KW - Curie-Weiss Potts Modell KW - Mischzeiten KW - MCMC-Verfahren Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-486769 ER - TY - JOUR A1 - Ty, Alexander J. A. A1 - Fang, Zheng A1 - Gonzalez, Rivver A. A1 - Rozdeba, Paul J. A1 - Abarbanel, Henry D. T1 - Machine learning of time series using time-delay embedding and precision annealing JF - Neural Computation N2 - Tasking machine learning to predict segments of a time series requires estimating the parameters of a ML model with input/output pairs from the time series. We borrow two techniques used in statistical data assimilation in order to accomplish this task: time-delay embedding to prepare our input data and precision annealing as a training method. The precision annealing approach identifies the global minimum of the action (-log[P]). In this way, we are able to identify the number of training pairs required to produce good generalizations (predictions) for the time series. We proceed from a scalar time series s(tn);tn=t0+n Delta t and, using methods of nonlinear time series analysis, show how to produce a DE>1-dimensional time-delay embedding space in which the time series has no false neighbors as does the observed s(tn) time series. In that DE-dimensional space, we explore the use of feedforward multilayer perceptrons as network models operating on DE-dimensional input and producing DE-dimensional outputs. Y1 - 2019 U6 - https://doi.org/10.1162/neco_a_01224 SN - 0899-7667 SN - 1530-888X VL - 31 IS - 10 SP - 2004 EP - 2024 PB - MIT Press CY - Cambridge ER - TY - CHAP A1 - Valleriani, Angelo A1 - Roelly, Sylvie A1 - Kulik, Alexei Michajlovič ED - Roelly, Sylvie ED - Högele, Michael ED - Rafler, Mathias T1 - Stochastic processes with applications in the natural sciences BT - international workshop at Universidad de los Andes, Bogotá, Colombia T2 - Lectures in pure and applied mathematics N2 - The interdisciplinary workshop STOCHASTIC PROCESSES WITH APPLICATIONS IN THE NATURAL SCIENCES was held in Bogotá, at Universidad de los Andes from December 5 to December 9, 2016. It brought together researchers from Colombia, Germany, France, Italy, Ukraine, who communicated recent progress in the mathematical research related to stochastic processes with application in biophysics. The present volume collects three of the four courses held at this meeting by Angelo Valleriani, Sylvie Rœlly and Alexei Kulik. A particular aim of this collection is to inspire young scientists in setting up research goals within the wide scope of fields represented in this volume. Angelo Valleriani, PhD in high energy physics, is group leader of the team "Stochastic processes in complex and biological systems" from the Max-Planck-Institute of Colloids and Interfaces, Potsdam. Sylvie Rœlly, Docteur en Mathématiques, is the head of the chair of Probability at the University of Potsdam. Alexei Kulik, Doctor of Sciences, is a Leading researcher at the Institute of Mathematics of Ukrainian National Academy of Sciences. T3 - Lectures in pure and applied mathematics - 4 KW - macromolecular decay KW - Markov processes KW - branching processes KW - long-time behaviour KW - makromolekularer Zerfall KW - Markovprozesse KW - Verzweigungsprozesse KW - Langzeitverhalten Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401802 SN - 978-3-86956-414-2 SN - 2199-4951 SN - 2199-496X IS - 4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Van Leeuwen, Peter Jan A1 - Cheng, Yuan A1 - Reich, Sebastian T1 - Nonlinear data assimilation T3 - Frontiers in applied dynamical systems: reviews and tutorials ; 2 N2 - This book contains two review articles on nonlinear data assimilation that deal with closely related topics but were written and can be read independently. Both contributions focus on so-called particle filters. The first contribution by Jan van Leeuwen focuses on the potential of proposal densities. It discusses the issues with present-day particle filters and explorers new ideas for proposal densities to solve them, converging to particle filters that work well in systems of any dimension, closing the contribution with a high-dimensional example. The second contribution by Cheng and Reich discusses a unified framework for ensemble-transform particle filters. This allows one to bridge successful ensemble Kalman filters with fully nonlinear particle filters, and allows a proper introduction of localization in particle filters, which has been lacking up to now. Y1 - 2015 SN - 978-3-319-18346-6 SN - 978-3-319-18347-3 U6 - https://doi.org/10.1007/978-3-319-18347-3 PB - Springer CY - Cham ER - TY - JOUR A1 - van Leeuwen, Peter Jan A1 - Kunsch, Hans R. A1 - Nerger, Lars A1 - Potthast, Roland A1 - Reich, Sebastian T1 - Particle filters for high-dimensional geoscience applications: A review JF - Quarterly journal of the Royal Meteorological Society N2 - Particle filters contain the promise of fully nonlinear data assimilation. They have been applied in numerous science areas, including the geosciences, but their application to high-dimensional geoscience systems has been limited due to their inefficiency in high-dimensional systems in standard settings. However, huge progress has been made, and this limitation is disappearing fast due to recent developments in proposal densities, the use of ideas from (optimal) transportation, the use of localization and intelligent adaptive resampling strategies. Furthermore, powerful hybrids between particle filters and ensemble Kalman filters and variational methods have been developed. We present a state-of-the-art discussion of present efforts of developing particle filters for high-dimensional nonlinear geoscience state-estimation problems, with an emphasis on atmospheric and oceanic applications, including many new ideas, derivations and unifications, highlighting hidden connections, including pseudo-code, and generating a valuable tool and guide for the community. Initial experiments show that particle filters can be competitive with present-day methods for numerical weather prediction, suggesting that they will become mainstream soon. KW - hybrids KW - localization KW - nonlinear data assimilation KW - particle filters KW - proposal densities Y1 - 2019 U6 - https://doi.org/10.1002/qj.3551 SN - 0035-9009 SN - 1477-870X VL - 145 IS - 723 SP - 2335 EP - 2365 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Vasiliev, Sergey B. A1 - Tarchanov, Nikolaj Nikolaevič T1 - Construction of series of perfect lattices by layer superposition JF - Journal of Siberian Federal University : Mathematics & physics JF - Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Serija Matematika i fizika = Mathematics & physics N2 - We construct a new series of perfect lattices in n dimensions by the layer superposition method of Delaunay-Barnes. KW - lattice packing and covering KW - polyhedra and polytopes KW - regular figures KW - division of spaces Y1 - 2017 U6 - https://doi.org/10.17516/1997-1397-2017-10-3-353-361 SN - 1997-1397 SN - 2313-6022 VL - 10 IS - 3 SP - 353 EP - 361 PB - Sibirskij Federalʹnyj Universitet CY - Krasnojarsk ER - TY - INPR A1 - Vasiliev, Serguei A1 - Tarkhanov, Nikolai Nikolaevich T1 - Construction of series of perfect lattices by layer superposition N2 - We construct a new series of perfect lattices in n dimensions by the layer superposition method of Delaunay-Barnes. T3 - Preprints des Instituts für Mathematik der Universität Potsdam - 5 (2016)11 KW - lattice packing and covering KW - polyhedra and polytopes KW - regular figures KW - division of spaces Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-100591 SN - 2193-6943 VL - 5 IS - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Vidal-Garcia, Marta A1 - Bandara, Lashi A1 - Keogh, J. Scott T1 - ShapeRotator BT - an R tool for standardized rigid rotations of articulated three-dimensional structures with application for geometric morphometrics JF - Ecology and evolution N2 - The quantification of complex morphological patterns typically involves comprehensive shape and size analyses, usually obtained by gathering morphological data from all the structures that capture the phenotypic diversity of an organism or object. Articulated structures are a critical component of overall phenotypic diversity, but data gathered from these structures are difficult to incorporate into modern analyses because of the complexities associated with jointly quantifying 3D shape in multiple structures. While there are existing methods for analyzing shape variation in articulated structures in two-dimensional (2D) space, these methods do not work in 3D, a rapidly growing area of capability and research. Here, we describe a simple geometric rigid rotation approach that removes the effect of random translation and rotation, enabling the morphological analysis of 3D articulated structures. Our method is based on Cartesian coordinates in 3D space, so it can be applied to any morphometric problem that also uses 3D coordinates (e.g., spherical harmonics). We demonstrate the method by applying it to a landmark-based dataset for analyzing shape variation using geometric morphometrics. We have developed an R tool (ShapeRotator) so that the method can be easily implemented in the commonly used R package geomorph and MorphoJ software. This method will be a valuable tool for 3D morphological analyses in articulated structures by allowing an exhaustive examination of shape and size diversity. KW - articulation KW - morphology KW - motion correction KW - multi-modular morphology Y1 - 2018 U6 - https://doi.org/10.1002/ece3.4018 SN - 2045-7758 VL - 8 IS - 9 SP - 4669 EP - 4675 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - Relations as morphisms of a certain monoidal category Y1 - 1997 ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - On functors between certain monoidal categories Y1 - 1998 ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - On quasivarieties generated by - algebras Y1 - 1995 ER - TY - BOOK A1 - Vogel, Hans-Jürgen T1 - On morphisms between partial algebras T3 - Preprint / Universität Potsdam, Institut für Mathematik Y1 - 1998 VL - 1998, 13 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - On morphisms between partial algebras Y1 - 1999 ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - Halfdiagonal-halfterminal-symmetric monoidal categories with inversions Y1 - 1999 ER - TY - JOUR A1 - Vogel, Hans-Jürgen T1 - On properties of dht -symmetric categories Y1 - 1999 ER - TY - JOUR A1 - Vogel, Hans-Jürgen A1 - Marki, Laszlo A1 - Pöschel, Reinhard T1 - Contributions to general algebra and categories Y1 - 1996 ER - TY - JOUR A1 - von Kleist, Max A1 - Menz, Stephan A1 - Stocker, Hartmut A1 - Arasteh, Keikawus A1 - Schuette, Christof A1 - Huisinga, Wilhelm T1 - HIV quasispecies dynamics during pro-active treatment switching impact on multi-drug resistance and resistance archiving in latent reservoirs JF - PLoS one N2 - The human immunodeficiency virus (HIV) can be suppressed by highly active anti-retroviral therapy (HAART) in the majority of infected patients. Nevertheless, treatment interruptions inevitably result in viral rebounds from persistent, latently infected cells, necessitating lifelong treatment. Virological failure due to resistance development is a frequent event and the major threat to treatment success. Currently, it is recommended to change treatment after the confirmation of virological failure. However, at the moment virological failure is detected, drug resistant mutants already replicate in great numbers. They infect numerous cells, many of which will turn into latently infected cells. This pool of cells represents an archive of resistance, which has the potential of limiting future treatment options. The objective of this study was to design a treatment strategy for treatment-naive patients that decreases the likelihood of early treatment failure and preserves future treatment options. We propose to apply a single, pro-active treatment switch, following a period of treatment with an induction regimen. The main goal of the induction regimen is to decrease the abundance of randomly generated mutants that confer resistance to the maintenance regimen, thereby increasing subsequent treatment success. Treatment is switched before the overgrowth and archiving of mutant strains that carry resistance against the induction regimen and would limit its future re-use. In silico modelling shows that an optimal trade-off is achieved by switching treatment at & 80 days after the initiation of antiviral therapy. Evaluation of the proposed treatment strategy demonstrated significant improvements in terms of resistance archiving and virological response, as compared to conventional HAART. While continuous pro-active treatment alternation improved the clinical outcome in a randomized trial, our results indicate that a similar improvement might also be reached after a single pro-active treatment switch. The clinical validity of this finding, however, remains to be shown by a corresponding trial. Y1 - 2011 U6 - https://doi.org/10.1371/journal.pone.0018204 SN - 1932-6203 VL - 6 IS - 3 PB - PLoS CY - San Fransisco ER - TY - INPR A1 - Voss, Carola Regine T1 - Harness-Prozesse N2 - Harness-Prozesse finden in der Forschung immer mehr Anwendung. Vor allem gewinnen Harness-Prozesse in stetiger Zeit an Bedeutung. Grundlegende Literatur zu diesem Thema ist allerdings wenig vorhanden. In der vorliegenden Arbeit wird die vorhandene Grundlagenliteratur zu Harness-Prozessen in diskreter und stetiger Zeit aufgearbeitet und Beweise ausgeführt, die bisher nur skizziert waren. Ziel dessen ist die Existenz einer Zerlegung von Harness-Prozessen über Z beziehungsweise R+ nachzuweisen. T3 - Mathematische Statistik und Wahrscheinlichkeitstheorie : Preprint - 2010, 13 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-49651 ER - TY - THES A1 - Vu, Dinh Phuong T1 - Using video study to investigate eighth-grade mathematics classrooms in Vietnam T1 - Die Nutzung von Videostudien zur Untersuchung des Mathematikunterrichts in der 8. Klasse in Vietnam N2 - The International Project for the Evaluation of Educational Achievement (IEA) was formed in the 1950s (Postlethwaite, 1967). Since that time, the IEA has conducted many studies in the area of mathematics, such as the First International Mathematics Study (FIMS) in 1964, the Second International Mathematics Study (SIMS) in 1980-1982, and a series of studies beginning with the Third International Mathematics and Science Study (TIMSS) which has been conducted every 4 years since 1995. According to Stigler et al. (1999), in the FIMS and the SIMS, U.S. students achieved low scores in comparison with students in other countries (p. 1). The TIMSS 1995 “Videotape Classroom Study” was therefore a complement to the earlier studies conducted to learn “more about the instructional and cultural processes that are associated with achievement” (Stigler et al., 1999, p. 1). The TIMSS Videotape Classroom Study is known today as the TIMSS Video Study. From the findings of the TIMSS 1995 Video Study, Stigler and Hiebert (1999) likened teaching to “mountain ranges poking above the surface of the water,” whereby they implied that we might see the mountaintops, but we do not see the hidden parts underneath these mountain ranges (pp. 73-78). By watching the videotaped lessons from Germany, Japan, and the United States again and again, they discovered that “the systems of teaching within each country look similar from lesson to lesson. At least, there are certain recurring features [or patterns] that typify many of the lessons within a country and distinguish the lessons among countries” (pp. 77-78). They also discovered that “teaching is a cultural activity,” so the systems of teaching “must be understood in relation to the cultural beliefs and assumptions that surround them” (pp. 85, 88). From this viewpoint, one of the purposes of this dissertation was to study some cultural aspects of mathematics teaching and relate the results to mathematics teaching and learning in Vietnam. Another research purpose was to carry out a video study in Vietnam to find out the characteristics of Vietnamese mathematics teaching and compare these characteristics with those of other countries. In particular, this dissertation carried out the following research tasks: - Studying the characteristics of teaching and learning in different cultures and relating the results to mathematics teaching and learning in Vietnam - Introducing the TIMSS, the TIMSS Video Study and the advantages of using video study in investigating mathematics teaching and learning - Carrying out the video study in Vietnam to identify the image, scripts and patterns, and the lesson signature of eighth-grade mathematics teaching in Vietnam - Comparing some aspects of mathematics teaching in Vietnam and other countries and identifying the similarities and differences across countries - Studying the demands and challenges of innovating mathematics teaching methods in Vietnam – lessons from the video studies Hopefully, this dissertation will be a useful reference material for pre-service teachers at education universities to understand the nature of teaching and develop their teaching career. N2 - Das International Project for the Evaluation of Educational Achievement (IEA) wurde in den 1950er Jahren gegründet. Seitdem führte das IEA viele Studien in Bereich mathematischer Bildung durch, insbesondere die First International Mathematics Study (FIMS) im Jahre 1964, die Second International Mathematics Study (SIMS) in den Jahren 1980–1982 und eine Reihe von Studien, die mit der Third International Mathematics and Science Study (TIMSS) begann und seit 1995 alle vier Jahre durchgeführt wird. Nach Stigler et al. (1999) erreichten US-amerikanische Studenten bei FIMS und SIMS niedrigere Ergebnisse als Schüler anderer Länder (S. 1). Daher wurde TIMSS 1995 erweitert um eine ‘Videotape Classroom Study’ mit dem Ziel, „mehr über die unterrichtlichen und kulturellen Prozesse, die mit Leistung zusammenhängen“, zu erfahren (S. 1; Übersetzung vom engl. Original). Von den Ergebnissen der TIMMS 1995 Video Study ausgehend verglichen Stigler und Hiebert (1999) Unterricht mit „Gebirgszügen, die die Wasseroberfläche durchstoßen“, womit sie ausdrücken sollten, was die Bergspitzen sichtbar, große Teile des Gebirges aber unter dem Wasser verborgen sind (S. 73–78; Übersetzung vom engl. Original). Durch die wiederholte Analyse videographierter Unterrichtsstunden aus Deutschland, Japan und den USA entdeckten sie, dass „die Arten des Unterrichts innerhalb jedes Landes von Stunde zu Stunde ähnlich sind. Zumindest gibt es bestimmte wiederkehrende Aspekte [oder Skripte], welche für viele Stunden eines Landes typisch sind und die Stunden gegenüber anderen Ländern abgrenzen“ (S. 77f.). Sie entdeckten außerdem, dass Unterricht eine „kulturelle Aktivität“ ist, Unterrichtsarten also „verstanden werden müssen in Relation zu den kulturellen Überzeugungen und Annahmen, die sie umgeben“ (S. 85, 88). Hierauf aufbauend war es ein Ziel der Dissertation, kulturelle Aspekte des Mathematikunterricht zu untersuchen und die Ergebnisse mit Mathematikunterricht in Vietnam zu vergleichen. Ein weiteres Ziel war die Erhebung der Charakteristika vietnamesischen Mathematikunterricht durch eine Videostudie in Vietnam und der anschließende Vergleich dieser Charakteristika mit denen anderer Länder. Im Einzelnen befasste sich diese Dissertation mit den folgenden Forschungszielen: - Untersuchung der Charakteristika von Lehren und Lernen in unterschiedlichen Kulturen und vorläufiger Vergleich der Resultate mit dem Lehren und Lernen von Mathematik in Vietnam - Einführung der TIMSS und der TIMSS Video Study und der methodologischen Vorteile von Videostudien für die Untersuchung von Mathematikunterricht in Vietnam - Durchführung der Videostudie in Vietnam, um Unterrichtsskripte des Mathematikunterrichts in 8. Klassen in Vietnam zu identifizieren - Vergleich ausgewählter Aspekte des Mathematikunterrichts in Vietnam mit denen anderer Länder auf der Grundlage der Videostudie in Vietnam und Diskussion von Ähnlichkeiten und Unterschieden zwischen Ländern - Untersuchung der Herausforderungen für eine Innovation der Unterrichtsmethoden im Mathematikunterricht Vietnams Diese Dissertation entstand in der Hoffnung, dass sie eine nützliche Referenz für Lehramtsstudenten zum Verständnis der Natur des Unterrichts und zur Entwicklung der eigenen Lehrerpersönlichkeit darstellen möge. KW - Videostudie KW - Mathematikunterricht KW - Unterrichtsmethode KW - TIMSS KW - Kulturelle Aktivität KW - video study KW - mathematics education KW - teaching methods KW - TIMSS KW - Vietnam Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-72464 ER - TY - JOUR A1 - Wallenta, D. T1 - Elliptic quasicomplexes on compact closed manifolds JF - Integral equations and operator theor N2 - We consider quasicomplexes of pseudodifferential operators on a smooth compact manifold without boundary. To each quasicomplex we associate a complex of symbols. The quasicomplex is elliptic if this symbol complex is exact away from the zero section. We prove that elliptic quasicomplexes are Fredholm. Moreover, we introduce the Euler characteristic for elliptic quasicomplexes and prove a generalisation of the Atiyah-Singer index theorem. KW - Elliptic complexes KW - Fredholm complexes KW - Index theory Y1 - 2012 U6 - https://doi.org/10.1007/s00020-012-1983-7 SN - 0378-620X VL - 73 IS - 4 SP - 517 EP - 536 PB - Springer CY - Basel ER - TY - JOUR A1 - Wallenta, Daniel T1 - A Lefschetz fixed point formula for elliptic quasicomplexes JF - Integral equations and operator theor N2 - In a recent paper, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes. KW - Elliptic complexes KW - Fredholm complexes KW - Lefschetz number Y1 - 2014 U6 - https://doi.org/10.1007/s00020-014-2122-4 SN - 0378-620X SN - 1420-8989 VL - 78 IS - 4 SP - 577 EP - 587 PB - Springer CY - Basel ER - TY - THES A1 - Wallenta, Daniel T1 - Sequences of compact curvature T1 - Sequenzen mit kompakter Krümmung N2 - By perturbing the differential of a (cochain-)complex by "small" operators, one obtains what is referred to as quasicomplexes, i.e. a sequence whose curvature is not equal to zero in general. In this situation the cohomology is no longer defined. Note that it depends on the structure of the underlying spaces whether or not an operator is "small." This leads to a magical mix of perturbation and regularisation theory. In the general setting of Hilbert spaces compact operators are "small." In order to develop this theory, many elements of diverse mathematical disciplines, such as functional analysis, differential geometry, partial differential equation, homological algebra and topology have to be combined. All essential basics are summarised in the first chapter of this thesis. This contains classical elements of index theory, such as Fredholm operators, elliptic pseudodifferential operators and characteristic classes. Moreover we study the de Rham complex and introduce Sobolev spaces of arbitrary order as well as the concept of operator ideals. In the second chapter, the abstract theory of (Fredholm) quasicomplexes of Hilbert spaces will be developed. From the very beginning we will consider quasicomplexes with curvature in an ideal class. We introduce the Euler characteristic, the cone of a quasiendomorphism and the Lefschetz number. In particular, we generalise Euler's identity, which will allow us to develop the Lefschetz theory on nonseparable Hilbert spaces. Finally, in the third chapter the abstract theory will be applied to elliptic quasicomplexes with pseudodifferential operators of arbitrary order. We will show that the Atiyah-Singer index formula holds true for those objects and, as an example, we will compute the Euler characteristic of the connection quasicomplex. In addition to this we introduce geometric quasiendomorphisms and prove a generalisation of the Lefschetz fixed point theorem of Atiyah and Bott. N2 - Die Theorie der Sequenzen mit kompakter Krümmung, sogenannter Quasikomplexe, ist eine Verallgemeinerung der Theorie der Fredholm Komplexe. Um ein Verständnis für (Quasi-)Komplexe zu gewinnen, müssen Inhalte aus verschiedenen Teilgebieten der Mathematik kombiniert werden. Alle hierfür wesentlichen Grundlagen sind im ersten Kapitel dieser Dissertation zusammengefasst. Dies betrifft unter anderem gewisse Elemente der Funktionalanalysis und der Differentialgeometrie, sowie die Theorie der klassischen Pseudodifferentialoperatoren. Im zweiten Kapitel wird anschließend die abstrakte Theorie der Quasikomplexe und zugehöriger Quasimorphismen im Kontext der Funktionalanalysis entwickelt. Dabei werden verschiedene Typen von Quasikomplexen und Quasimorphismen klassifiziert, deren Eigenschaften analysiert und Beispiele betrachtet. Ein zentraler Punkt hierbei ist die Lösung des Problems, für welche dieser Objekte sich eine besondere charakteristische Zahl, die sogenannte Lefschetz-Zahl, definieren lässt. Die dargestellten Resultate zeigen, dass die in dieser Arbeit gegebene Definition eine natürliche Erweiterung der klassischen Lefschetz-Zahl darstellt. Abschließend wird die entwickelte Theorie im dritten Kapitel auf elliptische Quasikomplexe von Pseudodifferentialoperatoren angewendet. Dabei werden insbesondere Verallgemeinerungen der berühmten Atiyah-Singer-Index-Formel und des Lefschetz-Fixpunkt-Theorems von Atiyah and Bott bewiesen. KW - Index Theorie KW - Fredholm Komplexe KW - Elliptische Komplexe KW - Index theory KW - Elliptic complexes KW - Fredholm complexes Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-87489 ER - TY - INPR A1 - Wallenta, Daniel T1 - A Lefschetz fixed point formula for elliptic quasicomplexes N2 - In a recent paper with N. Tarkhanov, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes. T3 - Preprints des Instituts für Mathematik der Universität Potsdam - 2(2013)12 KW - Perturbed complexes KW - curvature KW - Lefschetz number KW - fixed point formula Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-67016 ER - TY - THES A1 - Waltz, Christine T1 - Adjungierte Polynomideale und duale Typen auf Banachräumen und ihre Anwendung Y1 - 1994 ER - TY - BOOK A1 - Waltz, Christine T1 - Interpolation von holomorphen Typen T3 - Preprint / Universität Potsdam, Fachbereich Mathematik Y1 - 1992 VL - 1992, 01 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Wang, Guang A1 - Li, Pei-zhi A1 - Zhang, Shi-yao A1 - Zhong, Shan A1 - Chu, Chang A1 - Zeng, Shufei A1 - Yan, Yu A1 - Cheng, Xin A1 - Chuai, Manli A1 - Hocher, Berthold A1 - Yang, Xuesong T1 - Lipopolysaccharides (LPS) Induced Angiogenesis During Chicken Embryogenesis is Abolished by Combined ETA/ETB Receptor Blockade JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology N2 - Background/Aims: Angiogenesis plays a key role during embryonic development. The vascular endothelin (ET) system is involved in the regulation of angiogenesis. Lipopolysaccharides (LPS) could induce angiogenesis. The effects of ET blockers on baseline and LPS-stimulated angiogenesis during embryonic development remain unknown so far. Methods: The blood vessel density (BVD) of chorioallantoic membranes (CAMs), which were treated with saline (control), LPS, and/or BQ123 and the ETB blocker BQ788, were quantified and analyzed using an IPP 6.0 image analysis program. Moreover, the expressions of ET-1, ET-2, ET3, ET receptor A (ETRA), ET receptor B (ETRB) and VEGFR2 mRNA during embryogenesis were analyzed by semi-quantitative RT-PCR. Results: All components of the ET system are detectable during chicken embryogenesis. LPS increased angiogenesis substantially. This process was completely blocked by the treatment of a combination of the ETA receptor blockers-BQ123 and the ETB receptor blocker BQ788. This effect was accompanied by a decrease in ETRA, ETRB, and VEGFR2 gene expression. However, the baseline angiogenesis was not affected by combined ETA/ETB receptor blockade. Conclusion: During chicken embryogenesis, the LPS-stimulated angiogenesis, but not baseline angiogenesis, is sensitive to combined ETA/ETB receptor blockade. KW - Lipopolysaccharides (LPS) KW - Angiogenesis KW - Chicken chorioallantoic membrane (CAM) KW - Endothelin (ET) Y1 - 2018 U6 - https://doi.org/10.1159/000492547 SN - 1015-8987 SN - 1421-9778 VL - 48 IS - 5 SP - 2084 EP - 2090 PB - Karger CY - Basel ER - TY - JOUR A1 - Wang, Lifeng A1 - Hainzl, Sebastian A1 - Zöller, Gert A1 - Holschneider, Matthias T1 - Stress- and aftershock-constrained joint inversions for coseismic and postseismic slip applied to the 2004 M6.0 Parkfield earthquake JF - Journal of geophysical research : Solid earth N2 - Both aftershocks and geodetically measured postseismic displacements are important markers of the stress relaxation process following large earthquakes. Postseismic displacements can be related to creep-like relaxation in the vicinity of the coseismic rupture by means of inversion methods. However, the results of slip inversions are typically non-unique and subject to large uncertainties. Therefore, we explore the possibility to improve inversions by mechanical constraints. In particular, we take into account the physical understanding that postseismic deformation is stress-driven, and occurs in the coseismically stressed zone. We do joint inversions for coseismic and postseismic slip in a Bayesian framework in the case of the 2004 M6.0 Parkfield earthquake. We perform a number of inversions with different constraints, and calculate their statistical significance. According to information criteria, the best result is preferably related to a physically reasonable model constrained by the stress-condition (namely postseismic creep is driven by coseismic stress) and the condition that coseismic slip and large aftershocks are disjunct. This model explains 97% of the coseismic displacements and 91% of the postseismic displacements during day 1-5 following the Parkfield event, respectively. It indicates that the major postseismic deformation can be generally explained by a stress relaxation process for the Parkfield case. This result also indicates that the data to constrain the coseismic slip model could be enriched postseismically. For the 2004 Parkfield event, we additionally observe asymmetric relaxation process at the two sides of the fault, which can be explained by material contrast ratio across the fault of similar to 1.15 in seismic velocity. Y1 - 2012 U6 - https://doi.org/10.1029/2011JB009017 SN - 2169-9313 SN - 2169-9356 VL - 117 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Wang, Lifeng A1 - Zöller, Gert A1 - Hainzl, Sebastian T1 - Joint Determination of Slip and Stress Drop in a Bayesian Inversion Approach: A Case Study for the 2010 M8.8 Maule Earthquake JF - Pure and applied geophysics N2 - Stress drop is a key factor in earthquake mechanics and engineering seismology. However, stress drop calculations based on fault slip can be significantly biased, particularly due to subjectively determined smoothing conditions in the traditional least-square slip inversion. In this study, we introduce a mechanically constrained Bayesian approach to simultaneously invert for fault slip and stress drop based on geodetic measurements. A Gaussian distribution for stress drop is implemented in the inversion as a prior. We have done several synthetic tests to evaluate the stability and reliability of the inversion approach, considering different fault discretization, fault geometries, utilized datasets, and variability of the slip direction, respectively. We finally apply the approach to the 2010 M8.8 Maule earthquake and invert for the coseismic slip and stress drop simultaneously. Two fault geometries from the literature are tested. Our results indicate that the derived slip models based on both fault geometries are similar, showing major slip north of the hypocenter and relatively weak slip in the south, as indicated in the slip models of other studies. The derived mean stress drop is 5-6 MPa, which is close to the stress drop of similar to 7 MPa that was independently determined according to force balance in this region Luttrell et al. (J Geophys Res, 2011). These findings indicate that stress drop values can be consistently extracted from geodetic data. KW - Stress drop KW - Fault slip KW - Bayesian KW - Geodetic measurements Y1 - 2015 U6 - https://doi.org/10.1007/s00024-014-0868-x SN - 0033-4553 SN - 1420-9136 VL - 172 IS - 2 SP - 375 EP - 388 PB - Springer CY - Basel ER - TY - THES A1 - Wei, Yawei T1 - Operators on manifolds with edge and boundary with singular trace conditions Y1 - 2008 CY - Potsdam ER - TY - THES A1 - Wei, Yawei T1 - Operators on Manifolds with Edge and Boundary with Singular Trace Conditions Y1 - 2008 CY - Potsdam ER - TY - BOOK A1 - Weian, Liu T1 - Viscosity Solutions of Fully Nonlinea Parabolic Systems T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2002 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Weicker, Karsten T1 - Vorlesungs-Pflege BT - Maßnahmen zur Runderneuerung degenerierender Informatikvorlesungen JF - Commentarii informaticae didacticae N2 - Ähnlich zu Alterungsprozessen bei Software degenerieren auch Vorlesungen, wenn sie nicht hinreichend gepflegt werden. Die Gründe hierfür werden ebenso beleuchtet wie mögliche Indikatoren und Maßnahmen – der Blick ist dabei immer der eines Informatikers. An drei Vorlesungen wird erläutert, wie der Degeneration von Lehrveranstaltungen gegengewirkt werden kann. Mangels hinreichend großer empirischer Daten liefert das Paper keine unumstößlichen Wahrheiten. Ein Ziel ist es vielmehr Kollegen, die ähnliche Phänomene beobachten, einen ersten Anker für einen inneren Diskurs zu bieten. Ein langfristiges Ziel ist die Sammlung eines Katalogs an Maßnahmen zur Pflege von Informatikvorlesungen. KW - Wartung von Lehrveranstaltungen KW - Re-Engineering KW - Strukturverbesserung KW - Lehrevaluation KW - Degenerationsprozesse Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416315 IS - 12 SP - 47 EP - 59 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Weinelt, Ferdinand Anton A1 - Stegemann, Miriam Songa A1 - Theloe, Anja A1 - Pfäfflin, Frieder A1 - Achterberg, Stephan A1 - Weber, Franz A1 - Dübel, Lucas A1 - Mikolajewska, Agata A1 - Uhrig, Alexander A1 - Kiessling, Peggy A1 - Huisinga, Wilhelm A1 - Michelet, Robin A1 - Hennig, Stefanie A1 - Kloft, Charlotte T1 - Evaluation of a meropenem and piperacillin monitoring program in intensive care unit patients calls for the regular assessment of empirical targets and easy-to-use dosing decision tools JF - Antibiotics : open access journal N2 - The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets. To reliably achieve the targeted concentrations, dosing needs to be adjusted for renal function. We aimed to evaluate a meropenem and piperacillin/tazobactam monitoring program in intensive care unit (ICU) patients by assessing (i) the adequacy of locally selected empirical targets, (ii) if dosing is adequately adjusted for renal function and individual target, and (iii) if dosing is adjusted in target attainment (TA) failure. In a prospective, observational clinical trial of drug concentrations, relevant patient characteristics and microbiological data (pathogen, minimum inhibitory concentration (MIC)) for patients receiving meropenem or piperacillin/tazobactam treatment were collected. If the MIC value was available, a target range of 1-5 x MIC was selected for minimum drug concentrations of both drugs. If the MIC value was not available, 8-40 mg/L and 16-80 mg/L were selected as empirical target ranges for meropenem and piperacillin, respectively. A total of 356 meropenem and 216 piperacillin samples were collected from 108 and 96 ICU patients, respectively. The vast majority of observed MIC values was lower than the empirical target (meropenem: 90.0%, piperacillin: 93.9%), suggesting empirical target value reductions. TA was found to be low (meropenem: 35.7%, piperacillin 50.5%) with the lowest TA for severely impaired renal function (meropenem: 13.9%, piperacillin: 29.2%), and observed drug concentrations did not significantly differ between patients with different targets, indicating dosing was not adequately adjusted for renal function or target. Dosing adjustments were rare for both drugs (meropenem: 6.13%, piperacillin: 4.78%) and for meropenem irrespective of TA, revealing that concentration monitoring alone was insufficient to guide dosing adjustment. Empirical targets should regularly be assessed and adjusted based on local susceptibility data. To improve TA, scientific knowledge should be translated into easy-to-use dosing strategies guiding antibiotic dosing. KW - meropenem KW - piperacillin/tazobactam KW - antimicrobial stewardship KW - critically ill KW - antibiotics KW - pharmacokinetic/pharmacodynamic Y1 - 2022 U6 - https://doi.org/10.3390/antibiotics11060758 SN - 2079-6382 VL - 11 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Weiss, Andrea Y. A1 - Huisinga, Wilhelm T1 - Error-controlled global sensitivity analysis of ordinary differential equations JF - Journal of computational physics N2 - We propose a novel strategy for global sensitivity analysis of ordinary differential equations. It is based on an error-controlled solution of the partial differential equation (PDE) that describes the evolution of the probability density function associated with the input uncertainty/variability. The density yields a more accurate estimate of the output uncertainty/variability, where not only some observables (such as mean and variance) but also structural properties (e.g., skewness, heavy tails, bi-modality) can be resolved up to a selected accuracy. For the adaptive solution of the PDE Cauchy problem we use the Rothe method with multiplicative error correction, which was originally developed for the solution of parabolic PDEs. We show that, unlike in parabolic problems, conservation properties necessitate a coupling of temporal and spatial accuracy to avoid accumulation of spatial approximation errors over time. We provide convergence conditions for the numerical scheme and suggest an implementation using approximate approximations for spatial discretization to efficiently resolve the coupling of temporal and spatial accuracy. The performance of the method is studied by means of low-dimensional case studies. The favorable properties of the spatial discretization technique suggest that this may be the starting point for an error-controlled sensitivity analysis in higher dimensions. KW - ODE with random initial conditions KW - Global sensitivity analysis KW - Cauchy problem KW - Error control/adaptivity KW - Rothe method KW - Approximate approximations Y1 - 2011 U6 - https://doi.org/10.1016/j.jcp.2011.05.011 SN - 0021-9991 VL - 230 IS - 17 SP - 6824 EP - 6842 PB - Elsevier CY - San Diego ER - TY - GEN A1 - Weisser, Karin A1 - Stübler, Sabine A1 - Matheis, Walter A1 - Huisinga, Wilhelm T1 - Towards toxicokinetic modelling of aluminium exposure from adjuvants in medicinal products T2 - Regulatory toxicology and pharmacology : official journal of the International Society for Regulatory Toxicology and Pharmacology N2 - As a potentially toxic agent on nervous system and bone, the safety of aluminium exposure from adjuvants in vaccines and subcutaneous immune therapy (SCIT) products has to be continuously reevaluated, especially regarding concomitant administrations. For this purpose, knowledge on absorption and disposition of aluminium in plasma and tissues is essential. Pharmacokinetic data after vaccination in humans, however, are not available, and for methodological and ethical reasons difficult to obtain. To overcome these limitations, we discuss the possibility of an in vitro-in silico approach combining a toxicokinetic model for aluminium disposition with biorelevant kinetic absorption parameters from adjuvants. We critically review available kinetic aluminium-26 data for model building and, on the basis of a reparameterized toxicokinetic model (Nolte et al., 2001), we identify main modelling gaps. The potential of in vitro dissolution experiments for the prediction of intramuscular absorption kinetics of aluminium after vaccination is explored. It becomes apparent that there is need for detailed in vitro dissolution and in vivo absorption data to establish an in vitro-in vivo correlation (IVIVC) for aluminium adjuvants. We conclude that a combination of new experimental data and further refinement of the Nolte model has the potential to fill a gap in aluminium risk assessment. (C) 2017 Elsevier Inc. All rights reserved. KW - Aluminium KW - Aluminium adjuvants KW - Absorption kinetics KW - Toxicokinetic modelling KW - In vitro dissolution Y1 - 2017 U6 - https://doi.org/10.1016/j.yrtph.2017.02.018 SN - 0273-2300 SN - 1096-0295 VL - 88 SP - 310 EP - 321 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Weiße, Andrea Y. A1 - Middleton, Richard H. A1 - Huisinga, Wilhelm T1 - Quantifying uncertainty, variability and likelihood for ordinary differential equation models N2 - Background: In many applications, ordinary differential equation (ODE) models are subject to uncertainty or variability in initial conditions and parameters. Both, uncertainty and variability can be quantified in terms of a probability density function on the state and parameter space. Results: The partial differential equation that describes the evolution of this probability density function has a form that is particularly amenable to application of the well- known method of characteristics. The value of the density at some point in time is directly accessible by the solution of the original ODE extended by a single extra dimension (for the value of the density). This leads to simple methods for studying uncertainty, variability and likelihood, with significant advantages over more traditional Monte Carlo and related approaches especially when studying regions with low probability. Conclusions: While such approaches based on the method of characteristics are common practice in other disciplines, their advantages for the study of biological systems have so far remained unrecognized. Several examples illustrate performance and accuracy of the approach and its limitations. Y1 - 2010 UR - http://www.biomedcentral.com/1752-0509/ U6 - https://doi.org/10.1186/1752-0509-4-144 SN - 1752-0509 ER - TY - THES A1 - Welke, Dirk T1 - Hyperidentitäten partieller Algebren Y1 - 1996 ER - TY - BOOK A1 - Wendland, Horst T1 - Schwach-diskrete Bewegungsgruppen im Raum T3 - Preprint / Universität Potsdam, Institut für Mathematik Y1 - 1996 VL - 1996, 18 PB - Univ. CY - Potsdam ER - TY - BOOK A1 - Wenyi, Chen A1 - Tianbo, Wang T1 - The hypoellipticity of differential forms on closed manifolds T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2005 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Wenyi, Chen A1 - Tianbo, Wang T1 - The hypoellipticity of differential forms on closed manifolds N2 - In this paper we consider the hypo-ellipticity of differential forms on a closed manifold.The main results show that there are some topological obstruct for the existence of the differential forms with hypoellipticity. T3 - Preprint - (2005) 06 KW - Hypoellipticity KW - Form KW - Integrability KW - Diophantine Approximation Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-29803 ER - TY - INPR A1 - Weske, Mathias A1 - Rinderle-Ma, Stefanie A1 - Toumani, Farouk A1 - Wolf, Karsten T1 - Special section on BPM 2011 conference. - Special Issue T2 - Information systems Y1 - 2013 U6 - https://doi.org/10.1016/j.is.2013.01.003 SN - 0306-4379 VL - 38 IS - 4 SP - 545 EP - 546 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Wessel, Walter T1 - Are all complete plane multimaps but one bounded by Euler only? Y1 - 1995 ER - TY - JOUR A1 - Westphal, Anke T1 - Zur Wertorientierung in der instrumentalen Leistungsmotivation : glechtsspezifische Aspkte ; eine Studie an Brandenburger Musikschulen Y1 - 1996 ER - TY - JOUR A1 - Wicha, Sebastian G. A1 - Huisinga, Wilhelm A1 - Kloft, Charlotte T1 - Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against staphylococcus aureus exploiting in vitro information JF - CPT: pharmacometrics & systems pharmacology N2 - Broad-spectrum antibiotic combination therapy is frequently applied due to increasing resistance development of infective pathogens. The objective of the present study was to evaluate two common empiric broad-spectrum combination therapies consisting of either linezolid (LZD) or vancomycin (VAN) combined with meropenem (MER) against Staphylococcus aureus (S. aureus) as the most frequent causative pathogen of severe infections. A semimechanistic pharmacokinetic-pharmacodynamic (PK-PD) model mimicking a simplified bacterial life-cycle of S. aureus was developed upon time-kill curve data to describe the effects of LZD, VAN, and MER alone and in dual combinations. The PK-PD model was successfully (i) evaluated with external data from two clinical S. aureus isolates and further drug combinations and (ii) challenged to predict common clinical PK-PD indices and breakpoints. Finally, clinical trial simulations were performed that revealed that the combination of VAN-MER might be favorable over LZD-MER due to an unfavorable antagonistic interaction between LZD and MER. Y1 - 2017 U6 - https://doi.org/10.1002/psp4.12197 SN - 2163-8306 VL - 6 SP - 512 EP - 522 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Wicha, Sebastian G. A1 - Kees, Martin G. A1 - Solms, Alexander Maximilian A1 - Minichmayr, Iris K. A1 - Kratzer, Alexander A1 - Kloft, Charlotte T1 - TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine T2 - International journal of antimicrobial agents Y1 - 2015 U6 - https://doi.org/10.1016/j.ijantimicag.2014.12.010 SN - 0924-8579 SN - 1872-7913 VL - 45 IS - 4 SP - 442 EP - 444 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Wichitsa-nguan, Korakot T1 - Modifications and extensions of the logistic regression and Cox model T1 - Modifikationen und Erweiterungen des logistischen Regressionsmodells und des Cox-Modells N2 - In many statistical applications, the aim is to model the relationship between covariates and some outcomes. A choice of the appropriate model depends on the outcome and the research objectives, such as linear models for continuous outcomes, logistic models for binary outcomes and the Cox model for time-to-event data. In epidemiological, medical, biological, societal and economic studies, the logistic regression is widely used to describe the relationship between a response variable as binary outcome and explanatory variables as a set of covariates. However, epidemiologic cohort studies are quite expensive regarding data management since following up a large number of individuals takes long time. Therefore, the case-cohort design is applied to reduce cost and time for data collection. The case-cohort sampling collects a small random sample from the entire cohort, which is called subcohort. The advantage of this design is that the covariate and follow-up data are recorded only on the subcohort and all cases (all members of the cohort who develop the event of interest during the follow-up process). In this thesis, we investigate the estimation in the logistic model for case-cohort design. First, a model with a binary response and a binary covariate is considered. The maximum likelihood estimator (MLE) is described and its asymptotic properties are established. An estimator for the asymptotic variance of the estimator based on the maximum likelihood approach is proposed; this estimator differs slightly from the estimator introduced by Prentice (1986). Simulation results for several proportions of the subcohort show that the proposed estimator gives lower empirical bias and empirical variance than Prentice's estimator. Then the MLE in the logistic regression with discrete covariate under case-cohort design is studied. Here the approach of the binary covariate model is extended. Proving asymptotic normality of estimators, standard errors for the estimators can be derived. The simulation study demonstrates the estimation procedure of the logistic regression model with a one-dimensional discrete covariate. Simulation results for several proportions of the subcohort and different choices of the underlying parameters indicate that the estimator developed here performs reasonably well. Moreover, the comparison between theoretical values and simulation results of the asymptotic variance of estimator is presented. Clearly, the logistic regression is sufficient for the binary outcome refers to be available for all subjects and for a fixed time interval. Nevertheless, in practice, the observations in clinical trials are frequently collected for different time periods and subjects may drop out or relapse from other causes during follow-up. Hence, the logistic regression is not appropriate for incomplete follow-up data; for example, an individual drops out of the study before the end of data collection or an individual has not occurred the event of interest for the duration of the study. These observations are called censored observations. The survival analysis is necessary to solve these problems. Moreover, the time to the occurence of the event of interest is taken into account. The Cox model has been widely used in survival analysis, which can effectively handle the censored data. Cox (1972) proposed the model which is focused on the hazard function. The Cox model is assumed to be λ(t|x) = λ0(t) exp(β^Tx) where λ0(t) is an unspecified baseline hazard at time t and X is the vector of covariates, β is a p-dimensional vector of coefficient. In this thesis, the Cox model is considered under the view point of experimental design. The estimability of the parameter β0 in the Cox model, where β0 denotes the true value of β, and the choice of optimal covariates are investigated. We give new representations of the observed information matrix In(β) and extend results for the Cox model of Andersen and Gill (1982). In this way conditions for the estimability of β0 are formulated. Under some regularity conditions, ∑ is the inverse of the asymptotic variance matrix of the MPLE of β0 in the Cox model and then some properties of the asymptotic variance matrix of the MPLE are highlighted. Based on the results of asymptotic estimability, the calculation of local optimal covariates is considered and shown in examples. In a sensitivity analysis, the efficiency of given covariates is calculated. For neighborhoods of the exponential models, the efficiencies have then been found. It is appeared that for fixed parameters β0, the efficiencies do not change very much for different baseline hazard functions. Some proposals for applicable optimal covariates and a calculation procedure for finding optimal covariates are discussed. Furthermore, the extension of the Cox model where time-dependent coefficient are allowed, is investigated. In this situation, the maximum local partial likelihood estimator for estimating the coefficient function β(·) is described. Based on this estimator, we formulate a new test procedure for testing, whether a one-dimensional coefficient function β(·) has a prespecified parametric form, say β(·; ϑ). The score function derived from the local constant partial likelihood function at d distinct grid points is considered. It is shown that the distribution of the properly standardized quadratic form of this d-dimensional vector under the null hypothesis tends to a Chi-squared distribution. Moreover, the limit statement remains true when replacing the unknown ϑ0 by the MPLE in the hypothetical model and an asymptotic α-test is given by the quantiles or p-values of the limiting Chi-squared distribution. Finally, we propose a bootstrap version of this test. The bootstrap test is only defined for the special case of testing whether the coefficient function is constant. A simulation study illustrates the behavior of the bootstrap test under the null hypothesis and a special alternative. It gives quite good results for the chosen underlying model. References P. K. Andersen and R. D. Gill. Cox's regression model for counting processes: a large samplestudy. Ann. Statist., 10(4):1100{1120, 1982. D. R. Cox. Regression models and life-tables. J. Roy. Statist. Soc. Ser. B, 34:187{220, 1972. R. L. Prentice. A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika, 73(1):1{11, 1986. N2 - In vielen statistischen Anwendungen besteht die Aufgabe darin, die Beziehung zwischen Einflussgrößen und einer Zielgröße zu modellieren. Die Wahl eines geeigneten Modells hängt vom Typ der Zielgröße und vom Ziel der Untersuchung ab - während lineare Modelle für die Beschreibung des Zusammenhanges stetiger Outputs und Einflussgrößen genutzt werden, dienen logistische Regressionsmodelle zur Modellierung binärer Zielgrößen und das Cox-Modell zur Modellierung von Lebendauer-Daten. In epidemiologischen, medizinischen, biologischen, sozialen und ökonomischen Studien wird oftmals die logistische Regression angewendet, um den Zusammenhang zwischen einer binären Zielgröße und den erklärenden Variablen, den Kovariaten, zu modellieren. In epidemiologischen Studien muss häufig eine große Anzahl von Individuen für eine lange Zeit beobachtet werden. Um hierbei Kosten zu reduzieren, wird ein "Case-Cohort-Design" angewendet. Hierbei werden die Einflussgrößen nur für die Individuen erfasst, für die das interessierende Ereignis eintritt, und für eine zufällig gewählte kleine Teilmenge von Individuen, die Subkohorte. In der vorliegenden Arbeit wird das Schätzen im logistischen Regressionsmodell unter Case-Cohort-Design betrachtet. Für den Fall, dass auch die Kovariate binär ist, wurde bereits von Prentice (1986) die asymptotische Normalität des Maximum-Likelihood-Schätzers für den Logarithmus des "odds ratio", einen Parameter, der den Effekt der Kovariate charakterisiert, angegeben. In dieser Arbeit wird über einen Maximum-Likelihood-Zugang ein Schätzer für die Varianz der Grenzverteilung hergeleitet, für den durch empirische Untersuchungen gezeigt wird, dass er dem von Prentice überlegen ist. Ausgehend von dem binärem Kovariate-Modell werden Maximum-Likelihood-Schätzer für logistische Regressionsmodelle mit diskreten Kovariaten unter Case-Cohort-Design hergeleitet. Die asymptotische Normalität wird gezeigt; darauf aufbauend können Formeln für die Standardfehler angegeben werden. Simulationsstudien ergänzen diesen Abschnitt. Sie zeigen den Einfluss des Umfanges der Subkohorte auf die Varianz der Schätzer. Logistische Regression ist geeignet, wenn man das interessierende Ereignis für alle Individuen beobachten kann und wenn man ein festes Zeitintervall betrachtet. Will man die Zeit bis zum Eintreten eines Ereignisses bei der Untersuchung der Wirkung der Kovariate berücksichtigen, so sind Lebensdauermodelle angemessen. Hierbei können auch zensierte Daten behandelt werden. Ein sehr häufig angewendetes Regressionsmodell ist das von Cox (1972) vorgeschlagene, bei dem die Hazardrate durch λ(t|x) = λ0(t) exp(β^Tx) definiert ist. Hierbei ist λ0(t) eine unspezifizierte Baseline-Hazardrate und X ist ein Kovariat-Vektor, β ist ein p-dimensionaler Koeffizientenvektor. Nachdem ein Überblick über das Schätzen und Testen im Cox-Modell und seinen Erweiterungen gegeben wird, werden Aussagen zur Schätzbarkeit des Parameters β durch die "partiallikelihood"- Methode hergeleitet. Grundlage hierzu sind neue Darstellungen der beobachteten Fisher-Information, die die Ergebnisse von Andersen and Gill (1982) erweitern. Unter Regularitätsbedingungen ist der Schätzer asymptotisch normal; die Inverse der Grenzmatrix der Fisher-Information ist die Varianzmatrix der Grenzverteilung. Bedingungen für die Nichtsingularität dieser Grenzmatrix führen zum Begriff der asymptotischen Schätzbarkeit, der in der vorliegenden Arbeit ausführlich untersucht wird. Darüber hinaus ist diese Matrix Grundlage für die Herleitung lokal optimaler Kovariate. In einer Sensitivitätsanalyse wird die Effizienz gewählter Kovariate berechnet. Die Berechnungen zeigen, dass die Baseline-Verteilung nur wenig Einfluss auf die Effizienz hat. Entscheidend ist die Wahl der Kovariate. Es werden einige Vorschläge für anwendbare optimale Kovariate und Berechnungsverfahren für das Auffinden optimaler Kovariate diskutiert. Eine Erweiterung des Cox-Modells besteht darin, zeitabhängige Koeffizienten zuzulassen. Da diese Koeffizientenfunktionen nicht näher spezifiziert sind, werden sie nichtparametrisch geschätzt. Eine mögliche Methode ist die "local-linear-partial-likelihood"-Methode, deren Eigenschaften beispielsweise in der Arbeit von Cai and Sun (2003) untersucht wurden. In der vorliegenden Arbeit werden Simulationen zu dieser Methode durchgeführt. Hauptaspekt ist das Testen der Koeffizientenfunktion. Getestet wird, ob diese Funktion eine bestimmte parametrische Form besitzt. Betrachtet wird der Score-Vektor, der von der "localconstant-partial-likelihood"-Funktion abgeleitet wird. Ausgehend von der asymptotischen Normalität dieses Vektors an verschiedenen Gitterpunkten kann gezeigt werden, dass die Verteilung der geeignet standardisierten quadratischen Form unter der Nullhypothese gegen eine Chi-Quadrat-Verteilung konvergiert. Die Eigenschaften des auf dieser Grenzverteilungsaussage aufbauenden Tests hängen nicht nur vom Stichprobenumfang, sondern auch vom verwendeten Glättungsparameter ab. Deshalb ist es sinnvoll, auch einen Bootstrap-Test zu betrachten. In der vorliegenden Arbeit wird ein Bootstrap-Test zum Testen der Hypothese, dass die Koeffizienten-Funktion konstant ist, d.h. dass das klassische Cox-Modell vorliegt, vorgeschlagen. Der Algorithmus wird angegeben. Simulationen zum Verhalten dieses Tests unter der Nullhypothese und einer speziellen Alternative werden durchgeführt. Literatur P. K. Andersen and R. D. Gill. Cox's regression model for counting processes: a large sample study. Ann. Statist., 10(4):1100{1120, 1982. Z. Cai and Y. Sun. Local linear estimation for time-dependent coefficients in Cox's regression models. Scand. J. Statist., 30(1):93-111, 2003. D. R. Cox. Regression models and life-tables. J. Roy. Statist. Soc. Ser. B, 34:187-220, 1972. R. L. Prentice. A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika, 73(1):1-11, 1986. KW - survival analysis KW - Cox model KW - logistic regression analysis KW - logistische Regression KW - Case-Cohort-Design KW - Cox-Modell Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-90033 ER - TY - JOUR A1 - Wichitsa-Nguan, Korakot A1 - Läuter, Henning A1 - Liero, Hannelore T1 - Estimability in Cox models JF - Statistical Papers N2 - Our procedure of estimating is the maximum partial likelihood estimate (MPLE) which is the appropriate estimate in the Cox model with a general censoring distribution, covariates and an unknown baseline hazard rate . We find conditions for estimability and asymptotic estimability. The asymptotic variance matrix of the MPLE is represented and properties are discussed. KW - Cox model KW - Estimability KW - Asymptotic variance of maximum partial likelihood estimate Y1 - 2016 U6 - https://doi.org/10.1007/s00362-016-0755-x SN - 0932-5026 SN - 1613-9798 VL - 57 SP - 1121 EP - 1140 PB - Springer CY - New York ER - TY - JOUR A1 - Wiegner, Matthias A1 - Bösenberg, Jens A1 - Böckmann, Christine A1 - Eixmann, Ronald A1 - Freudenthaler, Volker A1 - Mattis, Ina A1 - Trickl, Thomas T1 - Lidar Network to Establish an Aerosol Climatology Y1 - 1999 ER - TY - GEN A1 - Wiljes, Jana de A1 - Tong, Xin T. T1 - Analysis of a localised nonlinear ensemble Kalman Bucy filter with complete and accurate observations T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Concurrent observation technologies have made high-precision real-time data available in large quantities. Data assimilation (DA) is concerned with how to combine this data with physical models to produce accurate predictions. For spatial-temporal models, the ensemble Kalman filter with proper localisation techniques is considered to be a state-of-the-art DA methodology. This article proposes and investigates a localised ensemble Kalman Bucy filter for nonlinear models with short-range interactions. We derive dimension-independent and component-wise error bounds and show the long time path-wise error only has logarithmic dependence on the time range. The theoretical results are verified through some simple numerical tests. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1221 KW - data assimilation KW - stability and accuracy KW - dimension independent bound KW - localisation KW - high dimensional KW - filter KW - nonlinear Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-540417 SN - 1866-8372 VL - 33 IS - 9 SP - 4752 EP - 4782 PB - IOP Publ. CY - Bristol ER - TY - JOUR A1 - Wiljes, Jana de A1 - Tong, Xin T. T1 - Analysis of a localised nonlinear ensemble Kalman Bucy filter with complete and accurate observations JF - Nonlinearity N2 - Concurrent observation technologies have made high-precision real-time data available in large quantities. Data assimilation (DA) is concerned with how to combine this data with physical models to produce accurate predictions. For spatial-temporal models, the ensemble Kalman filter with proper localisation techniques is considered to be a state-of-the-art DA methodology. This article proposes and investigates a localised ensemble Kalman Bucy filter for nonlinear models with short-range interactions. We derive dimension-independent and component-wise error bounds and show the long time path-wise error only has logarithmic dependence on the time range. The theoretical results are verified through some simple numerical tests. KW - data assimilation KW - stability and accuracy KW - dimension independent bound KW - localisation KW - high dimensional KW - filter KW - nonlinear Y1 - 2020 U6 - https://doi.org/10.1088/1361-6544/ab8d14 SN - 0951-7715 SN - 1361-6544 VL - 33 IS - 9 SP - 4752 EP - 4782 PB - IOP Publ. CY - Bristol ER - TY - JOUR A1 - Wismath, Shelly A1 - Koppitz, Jörg A1 - Denecke, Klaus-Dieter T1 - Maps between M-solid varieties of emigroups Y1 - 1997 ER - TY - JOUR A1 - Witt, Ingo T1 - Local asymptotic types N2 - The local theory of asymptotic types is elaborated. It appears as coordinate-free version of part of GOHBERG- SIGAL'S theory of the inversion of finitely meromorphic, operator-valued functions at a point Y1 - 2004 SN - 0025-2611 ER - TY - BOOK A1 - Witt, Ingo T1 - Green formulae for cone differential operators T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2003 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - THES A1 - Witt, Ingo T1 - Beiträge zur Theorie singulärer hyperbolischer Differentialoperatoren Y1 - 2003 CY - Potsdam ER - TY - BOOK A1 - Witt, Ingo T1 - A calculus for a class of finitely degenerate pseudodifferential operators T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2002 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - BOOK A1 - Witt, Ingo T1 - Local asymptotic types T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2002 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Witt, Ingo T1 - Green formulae for cone differential operators N2 - Green formulae for elliptic cone differential operators are established. This is achieved by an accurate description of the maximal domain of an elliptic cone differential operator and its formal adjoint; thereby utilizing the concept of a discrete asymptotic type. From this description, the singular coefficients replacing the boundary traces in classical Green formulas are deduced. T3 - Preprint - (2003) 20 Y1 - 2003 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26633 ER - TY - INPR A1 - Witt, Ingo T1 - A calculus for a class of finitely degenerate pseudodifferential operators N2 - For a class of degenerate pseudodifferential operators, local parametrices are constructed. This is done in the framework of a pseudodifferential calculus upon adding conditions of trace and potential type, respectively, along the boundary on which the operators degenerate. T3 - Preprint - (2002) 05 Y1 - 2002 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26246 ER - TY - INPR A1 - Witt, Ingo T1 - Asymptotic algebras N2 - The concept of asymptotic type that primarily appears in singular and asymptotic analysis is developed. Especially, asymptotic algebras are introduced. T3 - Preprint - (2001) 23 Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26069 ER - TY - INPR A1 - Witt, Ingo T1 - On the factorization of meromorphic Mellin symbols N2 - It is prooved that mermorphic, parameter-dependet elliptic Mellin symbols can be factorized in a particular way. The proof depends on the availability of logarithms of pseudodifferential operators. As a byproduct, we obtain a characterization of the group generated by pseudodifferential operators admitting a logarithm. The factorization has applications to the theory os pseudodifferential operators on spaces with conical singularities, e.g., to the index theory and the construction of various sub-calculi of the cone calculus. T3 - Preprint - (1999) 05 Y1 - 1999 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-25427 ER - TY - BOOK A1 - Witt, Ingo T1 - Asymptotic algebras T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2001 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - BOOK A1 - Witt, Ingo T1 - On the factorization of meromorphic mellin symbols T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 1999 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - BOOK A1 - Witt, Ingo T1 - Explicit algebras with the Leibniz-Mellin translation product T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 1999 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Witt, Ingo T1 - Local asymptotic types N2 - The local theory of asymptotic types is elaborated. It appears as coordinate-free version of part of GOHBERG-SIGAL's theory of the inversion of finitely meromorphic, operator-valued functions at a point. T3 - Preprint - (2002) 16 Y1 - 2002 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26346 ER - TY - BOOK A1 - Wollenberg, Manfred T1 - On an inverse problem in modular theory T3 - Preprint / Universität Potsdam, Institut für Mathematik Y1 - 1994 VL - 1994, 07 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Wormell, Caroline L. A1 - Reich, Sebastian T1 - Spectral convergence of diffusion maps BT - Improved error bounds and an alternative normalization JF - SIAM journal on numerical analysis / Society for Industrial and Applied Mathematics N2 - Diffusion maps is a manifold learning algorithm widely used for dimensionality reduction. Using a sample from a distribution, it approximates the eigenvalues and eigenfunctions of associated Laplace-Beltrami operators. Theoretical bounds on the approximation error are, however, generally much weaker than the rates that are seen in practice. This paper uses new approaches to improve the error bounds in the model case where the distribution is supported on a hypertorus. For the data sampling (variance) component of the error we make spatially localized compact embedding estimates on certain Hardy spaces; we study the deterministic (bias) component as a perturbation of the Laplace-Beltrami operator's associated PDE and apply relevant spectral stability results. Using these approaches, we match long-standing pointwise error bounds for both the spectral data and the norm convergence of the operator discretization. We also introduce an alternative normalization for diffusion maps based on Sinkhorn weights. This normalization approximates a Langevin diffusion on the sample and yields a symmetric operator approximation. We prove that it has better convergence compared with the standard normalization on flat domains, and we present a highly efficient rigorous algorithm to compute the Sinkhorn weights. KW - diffusion maps KW - graph Laplacian KW - Sinkhorn problem KW - kernel methods Y1 - 2021 U6 - https://doi.org/10.1137/20M1344093 SN - 0036-1429 SN - 1095-7170 VL - 59 IS - 3 SP - 1687 EP - 1734 PB - Society for Industrial and Applied Mathematics CY - Philadelphia ER - TY - INPR A1 - Xiaochun, Liu A1 - Schulze, Bert-Wolfgang T1 - Boundary value problems in edge representation N2 - Edge representations of operators on closed manifolds are known to induce large classes of operators that are elliptic on specific manifolds with edges, cf. [9]. We apply this idea to the case of boundary value problems. We establish a correspondence between standard ellipticity and ellipticity with respect to the principal symbolic hierarchy of the edge algebra of boundary value problems, where an embedded submanifold on the boundary plays the role of an edge. We first consider the case that the weight is equal to the smoothness and calculate the dimensions of kernels and cokernels of the associated principal edge symbols. Then we pass to elliptic edge operators for arbitrary weights and construct the additional edge conditions by applying relative index results for conormal symbols. T3 - Preprint - (2004) 14 KW - Boundary value problems KW - edge singularities KW - ellipticity in the edge calculus Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26746 ER - TY - INPR A1 - Xiaochun, Liu A1 - Witt, Ingo T1 - Pseudodifferential calculi on the half-line respecting prescribed asymptotic types N2 - Contents: 1. Introduction 2. Preliminaries 3. Basic Elements of the Calculus 4. Further Elements of the Calculus T3 - Preprint - (2002) 06 Y1 - 2002 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26255 ER - TY - INPR A1 - Xiaochun, Liu A1 - Witt, Ingo T1 - Asymptotic expansions for bounded solutions to semilinear Fuchsian equations N2 - It is shown that bounded solutions to semilinear elliptic Fuchsian equations obey complete asymptoic expansions in terms of powers and logarithms in the distance to the boundary. For that purpose, Schuze's notion of asymptotic type for conormal asymptotics close to a conical point is refined. This in turn allows to perform explicit calculations on asymptotic types - modulo the resolution of the spectral problem for determining the singular exponents in the asmptotic expansions. T3 - Preprint - (2001) 01 KW - Calculus of conormal symbols KW - conormal asymptotic expansions KW - discrete saymptotic types KW - weighted Sobolev spaces with discrete saymptotics Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-25912 ER - TY - JOUR A1 - Xiong, Chao A1 - Stolle, Claudia A1 - Alken, Patrick A1 - Rauberg, Jan T1 - Relationship between large-scale ionospheric field-aligned currents and electron/ion precipitations BT - DMSP observations JF - Earth, planets and space N2 - In this study, we have derived field-aligned currents (FACs) from magnetometers onboard the Defense Meteorological Satellite Project (DMSP) satellites. The magnetic latitude versus local time distribution of FACs from DMSP shows comparable dependences with previous findings on the intensity and orientation of interplanetary magnetic field (IMF)B(y)andB(z)components, which confirms the reliability of DMSP FAC data set. With simultaneous measurements of precipitating particles from DMSP, we further investigate the relation between large-scale FACs and precipitating particles. Our result shows that precipitation electron and ion fluxes both increase in magnitude and extend to lower latitude for enhanced southward IMFBz, which is similar to the behavior of FACs. Under weak northward and southwardB(z)conditions, the locations of the R2 current maxima, at both dusk and dawn sides and in both hemispheres, are found to be close to the maxima of the particle energy fluxes; while for the same IMF conditions, R1 currents are displaced further to the respective particle flux peaks. Largest displacement (about 3.5 degrees) is found between the downward R1 current and ion flux peak at the dawn side. Our results suggest that there exists systematic differences in locations of electron/ion precipitation and large-scale upward/downward FACs. As outlined by the statistical mean of these two parameters, the FAC peaks enclose the particle energy flux peaks in an auroral band at both dusk and dawn sides. Our comparisons also found that particle precipitation at dawn and dusk and in both hemispheres maximizes near the mean R2 current peaks. The particle precipitation flux maxima closer to the R1 current peaks are lower in magnitude. This is opposite to the known feature that R1 currents are on average stronger than R2 currents. KW - field-aligned currents KW - aurora KW - particle precipitation KW - DMSP Y1 - 2020 U6 - https://doi.org/10.1186/s40623-020-01286-z SN - 1880-5981 VL - 72 IS - 1 PB - Springer CY - New York ER - TY - INPR A1 - Yagdjian, Karen T1 - Geometric optics for the nonlinear hyperbolic systems of Kirchhoff-type N2 - Contents: 1 Introduction 2 Main result 3 Construction of the asymptotic solutions 3.1 Derivation of the equations for the profiles 3.2 Exsistence of the principal profile 3.3 Determination of Usub(2) and the remaining profiles 4 Stability of the samll global solutions. Justification of One Phase Nonlinear Geometric Optics for the Kirchhoff-type equations 4.1 Stability of the global solutions to the Kirchhoff-type symmetric hyperbolic systems 4.2 The nonlinear system of ordinary differential equations with the parameter 4.3 Some energies estimates 4.4 The dependence of the solution W(t, ξ) on the function s(t) 4.5 The oscillatory integrals of the bilinear forms of the solutions 4.6 Estimates for the basic bilinear form Γsub(s)(t) 4.7 Contraction mapping 4.8 Stability of the global solution 4.9 Justification of One Phase Nonlinear Geometric Optics for the Kirchhoff-type equations T3 - Preprint - (2001) 22 Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26059 ER - TY - BOOK A1 - Yagdjian, Karen T1 - Geometric optics for the nonlinear hyperbolic systems of kirchhoff-type T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2001 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - BOOK A1 - Yagdjian, Karen A1 - Galstian, Anahit T1 - Fundamental solutions for Wave Equation in de Sitter Model of Universe T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2007 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Yagdjian, Karen A1 - Galstian, Anahit T1 - Fundamental solutions for wave equation in de Sitter model of universe N2 - In this article we construct the fundamental solutions for the wave equation arising in the de Sitter model of the universe. We use the fundamental solutions to represent solutions of the Cauchy problem and to prove the Lp − Lq-decay estimates for the solutions of the equation with and without a source term. T3 - Preprint - (2007) 06 KW - de Sitter model ; Fundamental solutions ; Decay estimates Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30271 ER - TY - JOUR A1 - Yen, Ming-Hsuan A1 - von Specht, Sebastian A1 - Lin, Yen-Yu A1 - Cotton, Fabrice A1 - Ma, Kuo-Fong T1 - Within- and between-event variabilities of strong-velocity pulses of moderate earthquakes within dense seismic arrays JF - Bulletin of the Seismological Society of America N2 - Ground motion with strong-velocity pulses can cause significant damage to buildings and structures at certain periods; hence, knowing the period and velocity amplitude of such pulses is critical for earthquake structural engineering. However, the physical factors relating the scaling of pulse periods with magnitude are poorly understood. In this study, we investigate moderate but damaging earthquakes (M-w 6-7) and characterize ground- motion pulses using the method of Shahi and Baker (2014) while considering the potential static-offset effects. We confirm that the within-event variability of the pulses is large. The identified pulses in this study are mostly from strike-slip-like earthquakes. We further perform simulations using the freq uency-wavenumber algorithm to investigate the causes of the variability of the pulse periods within and between events for moderate strike-slip earthquakes. We test the effect of fault dips, and the impact of the asperity locations and sizes. The simulations reveal that the asperity properties have a high impact on the pulse periods and amplitudes at nearby stations. Our results emphasize the importance of asperity characteristics, in addition to earthquake magnitudes for the occurrence and properties of pulses produced by the forward directivity effect. We finally quantify and discuss within- and between-event variabilities of pulse properties at short distances. Y1 - 2021 U6 - https://doi.org/10.1785/0120200376 SN - 0037-1106 SN - 1943-3573 VL - 112 IS - 1 SP - 361 EP - 380 PB - Seismological Society of America CY - El Cerito, Calif. ER - TY - INPR A1 - Yihong, Du A1 - Li, Ma T1 - Some remarks related to De Giorgi's conjecture N2 - For several classes of functions including the special case f(u) = u − u³, we obtain boundedness and symmetry results for solutions of the problem −Δu = f(u) defined on R up(n). Our results complement a number of recent results related to a conjecture of De Giorgi. T3 - Preprint - (2001) 18 Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26027 ER - TY - JOUR A1 - Yin, H. C. A1 - Witt, Ingo T1 - Global singularity structure of weak solutions to 3-D semilinear dispersive wave equations with discontinuous initial data N2 - We study the global singularity structure of solutions to 3-D semilinear wave equations with discontinuous initial data. More precisely, using Strichartz' inequality we show that the solutions stay conormal after nonlinear interaction if the Cauchy data are conormal along a circle. (C) 2003 Elsevier Inc. All rights reserved Y1 - 2004 SN - 0022-0396 ER - TY - INPR A1 - Yin, Huicheng T1 - Formation and construction of a shock wave for 3-D compressible Euler equations with spherical initial data N2 - In this paper, the problem on formation and construction of a shock wave for three dimensional compressible Euler equations with the small perturbed spherical initial data is studied. If the given smooth initial data satisfies certain nondegenerate condition, then from the results in [20], we know that there exists a unique blowup point at the blowup time such that the first order derivates of smooth solution blow up meanwhile the solution itself is still continuous at the blowup point. From the blowup point, we construct a weak entropy solution which is not uniformly Lipschitz continuous on two sides of shock curve, moreover the strength of the constructed shock is zero at the blowup point and then gradually increases. Additionally, some detailed and precise estimates on the solution are obtained in the neighbourhood of the blowup point. T3 - Preprint - (2002) 07 KW - compressible Euler equations KW - lifespan KW - nondegenerate condition KW - shock wave Y1 - 2002 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26263 ER - TY - INPR A1 - Yin, Huicheng T1 - Global existence of a shock for the supersonic flow past a curved wedge N2 - This note is devoted to the study on the global existence of a shock wave for the supersonic flow past a curved wedge. When the curved wedge is a small perturbation of a straight wedge and the angle of the wedge is less than some critical value, wwe show that a shock attached at the wedge will exist globally. T3 - Preprint - (2002) 08 Y1 - 2002 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-26272 ER - TY - BOOK A1 - Yin, Huicheng A1 - Witt, Ingo T1 - Global singularity structure of weak solutions to 3-D semilinear dispersive wave equaions with discontinuous initial data T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2002 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - GEN A1 - Yin, Yang A1 - Hua, Chen T1 - On chemotaxis systems with saturation growth T2 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2007 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - INPR A1 - Yin, Yang A1 - Hua, Chen T1 - On chemotaxis systems with saturation growth N2 - In this paper, we discuss the global existence of solutions for Chemotaxis models with saturation growth. If the coe±cients of the equations are all positive smooth T-periodic functions, then the problem has a positive T-periodic solution, and meanwhile we discuss here the stability problems for the T-periodic solutions. T3 - Preprint - (2007) 04 KW - Saturation model KW - Chemotaxis KW - global solution KW - asymptotic stable Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30254 ER - TY - BOOK A1 - Yin, Yang A1 - Hua, Chen A1 - Weian, Liu T1 - On solutions of the chemotaxis equations T3 - Preprint / Universität Potsdam, Institut für Mathematik Y1 - 1998 VL - 1998, 06 PB - Univ. CY - Potsdam ER - TY - THES A1 - Zadorozhnyi, Oleksandr T1 - Contributions to the theoretical analysis of the algorithms with adversarial and dependent data N2 - In this work I present the concentration inequalities of Bernstein's type for the norms of Banach-valued random sums under a general functional weak-dependency assumption (the so-called $\cC-$mixing). The latter is then used to prove, in the asymptotic framework, excess risk upper bounds of the regularised Hilbert valued statistical learning rules under the τ-mixing assumption on the underlying training sample. These results (of the batch statistical setting) are then supplemented with the regret analysis over the classes of Sobolev balls of the type of kernel ridge regression algorithm in the setting of online nonparametric regression with arbitrary data sequences. Here, in particular, a question of robustness of the kernel-based forecaster is investigated. Afterwards, in the framework of sequential learning, the multi-armed bandit problem under $\cC-$mixing assumption on the arm's outputs is considered and the complete regret analysis of a version of Improved UCB algorithm is given. Lastly, probabilistic inequalities of the first part are extended to the case of deviations (both of Azuma-Hoeffding's and of Burkholder's type) to the partial sums of real-valued weakly dependent random fields (under the type of projective dependence condition). KW - Machine learning KW - nonparametric regression KW - kernel methods KW - regularisation KW - concentration inequalities KW - learning rates KW - sequential learning KW - multi-armed bandits KW - Sobolev spaces Y1 - 2021 ER - TY - JOUR A1 - Zagrebnov, Valentin T1 - Trotter product formula on Hilbert and Banach spaces for operator-norm convergence JF - Lectures in pure and applied mathematics KW - random point processes KW - statistical mechanics KW - stochastic analysis Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-471971 SN - 978-3-86956-485-2 SN - 2199-4951 SN - 2199-496X SP - 23 EP - 34 PB - Universitätsverlag Potsdam CY - Potsdam ER -