TY - JOUR A1 - Tang, Alan T. A1 - Sullivan, Katie Rose A1 - Hong, Courtney C. A1 - Goddard, Lauren M. A1 - Mahadevan, Aparna A1 - Ren, Aileen A1 - Pardo, Heidy A1 - Peiper, Amy A1 - Griffin, Erin A1 - Tanes, Ceylan A1 - Mattei, Lisa M. A1 - Yang, Jisheng A1 - Li, Li A1 - Mericko-Ishizuka, Patricia A1 - Shen, Le A1 - Hobson, Nicholas A1 - Girard, Romuald A1 - Lightle, Rhonda A1 - Moore, Thomas A1 - Shenkar, Robert A1 - Polster, Sean P. A1 - Roedel, Claudia Jasmin A1 - Li, Ning A1 - Zhu, Qin A1 - Whitehead, Kevin J. A1 - Zheng, Xiangjian A1 - Akers, Amy A1 - Morrison, Leslie A1 - Kim, Helen A1 - Bittinger, Kyle A1 - Lengner, Christopher J. A1 - Schwaninger, Markus A1 - Velcich, Anna A1 - Augenlicht, Leonard A1 - Abdelilah-Seyfried, Salim A1 - Min, Wang A1 - Marchuk, Douglas A. A1 - Awad, Issam A. A1 - Kahn, Mark L. T1 - Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation JF - Science Translational Medicine N2 - Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in KRIT1, CCM2, or PDCD10. Disease onset is earlier and more severe in individuals with PDCD10 mutations. Recent studies have shown that lesions arise from excess mitogen-activated protein kinase kinase kinase 3 (MEKK3) signaling downstream of Toll-like receptor 4 (TLR4) stimulation by lipopolysaccharide derived from the gut microbiome. These findings suggest a gut-brain CCM disease axis but fail to define it or explain the poor prognosis of patients with PDCD10 mutations. Here, we demonstrate that the gut barrier is a primary determinant of CCM disease course, independent of microbiome configuration, that explains the increased severity of CCM disease associated with PDCD10 deficiency. Chemical disruption of the gut barrier with dextran sulfate sodium augments CCM formation in a mouse model, as does genetic loss of Pdcd10, but not Krit1, in gut epithelial cells. Loss of gut epithelial Pdcd10 results in disruption of the colonic mucosal barrier. Accordingly, loss of Mucin-2 or exposure to dietary emulsifiers that reduce the mucus barrier increases CCM burden analogous to loss of Pdcd10 in the gut epithelium. Last, we show that treatment with dexamethasone potently inhibits CCM formation in mice because of the combined effect of action at both brain endothelial cells and gut epithelial cells. These studies define a gut-brain disease axis in an experimental model of CCM in which a single gene is required for two critical components: gut epithelial function and brain endothelial signaling. Y1 - 2019 U6 - https://doi.org/10.1126/scitranslmed.aaw3521 SN - 1946-6234 SN - 1946-6242 VL - 11 IS - 520 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Yang, Jie A1 - Zhu, Xiaolei A1 - Wolf, Thomas J. A. A1 - Li, Zheng A1 - Nunes, João Pedro Figueira A1 - Coffee, Ryan A1 - Cryan, James P. A1 - Gühr, Markus A1 - Hegazy, Kareem A1 - Heinz, Tony F. A1 - Jobe, Keith A1 - Li, Renkai A1 - Shen, Xiaozhe A1 - Veccione, Theodore A1 - Weathersby, Stephen A1 - Wilkin, Kyle J. A1 - Yoneda, Charles A1 - Zheng, Qiang A1 - Martinez, Todd J. A1 - Centurion, Martin A1 - Wang, Xijie T1 - Imaging CF3I conical intersection and photodissociation dynamics with ultrafast electron diffraction JF - Science N2 - Conical intersections play a critical role in excited-state dynamics of polyatomic molecules because they govern the reaction pathways of many nonadiabatic processes. However, ultrafast probes have lacked sufficient spatial resolution to image wave-packet trajectories through these intersections directly. Here, we present the simultaneous experimental characterization of one-photon and two-photon excitation channels in isolated CF3I molecules using ultrafast gas-phase electron diffraction. In the two-photon channel, we have mapped out the real-space trajectories of a coherent nuclear wave packet, which bifurcates onto two potential energy surfaces when passing through a conical intersection. In the one-photon channel, we have resolved excitation of both the umbrella and the breathing vibrational modes in the CF3 fragment in multiple nuclear dimensions. These findings benchmark and validate ab initio nonadiabatic dynamics calculations. Y1 - 2018 U6 - https://doi.org/10.1126/science.aat0049 SN - 0036-8075 SN - 1095-9203 VL - 361 IS - 6397 SP - 64 EP - 67 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Banks, Jo Ann A1 - Nishiyama, Tomoaki A1 - Hasebe, Mitsuyasu A1 - Bowman, John L. A1 - Gribskov, Michael A1 - dePamphilis, Claude A1 - Albert, Victor A. A1 - Aono, Naoki A1 - Aoyama, Tsuyoshi A1 - Ambrose, Barbara A. A1 - Ashton, Neil W. A1 - Axtell, Michael J. A1 - Barker, Elizabeth A1 - Barker, Michael S. A1 - Bennetzen, Jeffrey L. A1 - Bonawitz, Nicholas D. A1 - Chapple, Clint A1 - Cheng, Chaoyang A1 - Correa, Luiz Gustavo Guedes A1 - Dacre, Michael A1 - DeBarry, Jeremy A1 - Dreyer, Ingo A1 - Elias, Marek A1 - Engstrom, Eric M. A1 - Estelle, Mark A1 - Feng, Liang A1 - Finet, Cedric A1 - Floyd, Sandra K. A1 - Frommer, Wolf B. A1 - Fujita, Tomomichi A1 - Gramzow, Lydia A1 - Gutensohn, Michael A1 - Harholt, Jesper A1 - Hattori, Mitsuru A1 - Heyl, Alexander A1 - Hirai, Tadayoshi A1 - Hiwatashi, Yuji A1 - Ishikawa, Masaki A1 - Iwata, Mineko A1 - Karol, Kenneth G. A1 - Koehler, Barbara A1 - Kolukisaoglu, Uener A1 - Kubo, Minoru A1 - Kurata, Tetsuya A1 - Lalonde, Sylvie A1 - Li, Kejie A1 - Li, Ying A1 - Litt, Amy A1 - Lyons, Eric A1 - Manning, Gerard A1 - Maruyama, Takeshi A1 - Michael, Todd P. A1 - Mikami, Koji A1 - Miyazaki, Saori A1 - Morinaga, Shin-ichi A1 - Murata, Takashi A1 - Müller-Röber, Bernd A1 - Nelson, David R. A1 - Obara, Mari A1 - Oguri, Yasuko A1 - Olmstead, Richard G. A1 - Onodera, Naoko A1 - Petersen, Bent Larsen A1 - Pils, Birgit A1 - Prigge, Michael A1 - Rensing, Stefan A. A1 - Mauricio Riano-Pachon, Diego A1 - Roberts, Alison W. A1 - Sato, Yoshikatsu A1 - Scheller, Henrik Vibe A1 - Schulz, Burkhard A1 - Schulz, Christian A1 - Shakirov, Eugene V. A1 - Shibagaki, Nakako A1 - Shinohara, Naoki A1 - Shippen, Dorothy E. A1 - Sorensen, Iben A1 - Sotooka, Ryo A1 - Sugimoto, Nagisa A1 - Sugita, Mamoru A1 - Sumikawa, Naomi A1 - Tanurdzic, Milos A1 - Theissen, Guenter A1 - Ulvskov, Peter A1 - Wakazuki, Sachiko A1 - Weng, Jing-Ke A1 - Willats, William W. G. T. A1 - Wipf, Daniel A1 - Wolf, Paul G. A1 - Yang, Lixing A1 - Zimmer, Andreas D. A1 - Zhu, Qihui A1 - Mitros, Therese A1 - Hellsten, Uffe A1 - Loque, Dominique A1 - Otillar, Robert A1 - Salamov, Asaf A1 - Schmutz, Jeremy A1 - Shapiro, Harris A1 - Lindquist, Erika A1 - Lucas, Susan A1 - Rokhsar, Daniel A1 - Grigoriev, Igor V. T1 - The selaginella genome identifies genetic changes associated with the evolution of vascular plants JF - Science N2 - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes. Y1 - 2011 U6 - https://doi.org/10.1126/science.1203810 SN - 0036-8075 VL - 332 IS - 6032 SP - 960 EP - 963 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - GEN A1 - Shan, Yuli A1 - Guan, Dabo A1 - Hubacek, Klaus A1 - Zheng, Bo A1 - Davis, Steven J. A1 - Jia, Lichao A1 - Liu, Jianghua A1 - Liu, Zhu A1 - Fromer, Neil A1 - Mi, Zhifu A1 - Meng, Jing A1 - Deng, Xiangzheng A1 - Li, Yuan A1 - Lin, Jintai A1 - Schroeder, Heike A1 - Weisz, Helga A1 - Schellnhuber, Hans Joachim T1 - City-level climate change mitigation in China T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - As national efforts to reduce CO2 emissions intensify, policy-makers need increasingly specific, subnational information about the sources of CO2 and the potential reductions and economic implications of different possible policies. This is particularly true in China, a large and economically diverse country that has rapidly industrialized and urbanized and that has pledged under the Paris Agreement that its emissions will peak by 2030. We present new, city level estimates of CO2 emissions for 182 Chinese cities, decomposed into 17 different fossil fuels, 46 socioeconomic sectors, and 7 industrial processes. We find that more affluent cities have systematically lower emissions per unit of gross domestic product (GDP), supported by imports from less affluent, industrial cities located nearby. In turn, clusters of industrial cities are supported by nearby centers of coal or oil extraction. Whereas policies directly targeting manufacturing and electric power infrastructure would drastically undermine the GDP of industrial cities, consumption based policies might allow emission reductions to be subsidized by those with greater ability to pay. In particular, sector based analysis of each city suggests that technological improvements could be a practical and effective means of reducing emissions while maintaining growth and the current economic structure and energy system. We explore city-level emission reductions under three scenarios of technological progress to show that substantial reductions (up to 31%) are possible by updating a disproportionately small fraction of existing infrastructure. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1096 KW - carbon-dioxide emissions KW - fired power plants KW - co2 emissions KW - energy use KW - cluster analysis KW - uncertainties KW - urbanization KW - methodology KW - combustion KW - inventory Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-471541 SN - 1866-8372 IS - 1096 ER - TY - JOUR A1 - Cheng, Shifeng A1 - van den Bergh, Erik A1 - Zeng, Peng A1 - Zhong, Xiao A1 - Xu, Jiajia A1 - Liu, Xin A1 - Hofberger, Johannes A1 - de Bruijn, Suzanne A1 - Bhide, Amey S. A1 - Kuelahoglu, Canan A1 - Bian, Chao A1 - Chen, Jing A1 - Fan, Guangyi A1 - Kaufmann, Kerstin A1 - Hall, Jocelyn C. A1 - Becker, Annette A1 - Bräutigam, Andrea A1 - Weber, Andreas P. M. A1 - Shi, Chengcheng A1 - Zheng, Zhijun A1 - Li, Wujiao A1 - Lv, Mingju A1 - Tao, Yimin A1 - Wang, Junyi A1 - Zou, Hongfeng A1 - Quan, Zhiwu A1 - Hibberd, Julian M. A1 - Zhang, Gengyun A1 - Zhu, Xin-Guang A1 - Xu, Xun A1 - Schranz, M. Eric T1 - The Tarenaya hassleriana Genome Provides insight Into Reproductive Trait and Genome Evolution of Crucifers JF - The plant cell N2 - The Brassicaceae, including Arabidopsis thaliana and Brassica crops, is unmatched among plants in its wealth of genomic and functional molecular data and has long served as a model for understanding gene, genome, and trait evolution. However, genome information from a phylogenetic outgroup that is essential for inferring directionality of evolutionary change has been lacking. We therefore sequenced the genome of the spider flower (Tarenaya hassleriana) from the Brassicaceae sister family, the Cleomaceae. By comparative analysis of the two lineages, we show that genome evolution following ancient polyploidy and gene duplication events affect reproductively important traits. We found an ancient genome triplication in Tarenaya (Th-alpha) that is independent of the Brassicaceae-specific duplication (At-alpha) and nested Brassica (Br-a) triplication. To showcase the potential of sister lineage genome analysis, we investigated the state of floral developmental genes and show Brassica retains twice as many floral MADS (for MINICHROMOSOME MAINTENANCE1, AGAMOUS, DEFICIENS and SERUM RESPONSE FACTOR) genes as Tarenaya that likely contribute to morphological diversity in Brassica. We also performed synteny analysis of gene families that confer self-incompatibility in Brassicaceae and found that the critical SERINE RECEPTOR KINASE receptor gene is derived from a lineage-specific tandem duplication. The T. hassleriana genome will facilitate future research toward elucidating the evolutionary history of Brassicaceae genomes. Y1 - 2013 U6 - https://doi.org/10.1105/tpc.113.113480 SN - 1040-4651 VL - 25 IS - 8 SP - 2813 EP - 2830 PB - American Society of Plant Physiologists CY - Rockville ER - TY - JOUR A1 - Liang, Xu-Jing A1 - Huang, Si-Min A1 - Li, Jian-Ping A1 - Zhu, Xian-Nv A1 - Lu, Yong-Ping A1 - Hocher, Berthold A1 - Chen, You-Peng T1 - Hepatic impairment induced by scrub typhus is associated with new onset of renal dysfunction JF - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion N2 - Background: Scrub typhus is a potentially fatal infectious disease caused by Orientia tsutsugamushi. There is little attention given to hepatic impairment in the adults with scrub typhus. This study investigated the incidence and the prognostic implications of hepatic impairment in patients with scrub typhus. Methods: We retrospectively reviewed a total of 143 adult patients with scrub typhus who were admitted between January 1999 and December 2010 in Guangdong province, China. The patients were divided into three groups, e.g., normal, mild, and moderate to severe groups based on the elevated serum ALT and/or total bilirubin levels. Furthermore, clinical characteristics and prognosis of the patient groups were compared. Results: 109 patients (76.2%) had abnormal liver function. Among the patients with hepatic impairment 45 cases (31.4%), 54 cases (37.8%), and 10 cases (7.0%) had mild, moderate, and severe hepatic damage, respectively. The moderate to severe hepatic impairment group had higher levels of serum creatinine compared with that of normal hepatic function. The incidence of new onset of renal dysfunction - defined as peak serum creatinine >= 176 mu mol/L during hospital stay with no evidence of renal disease prior hospitalization - was 0% in the mild hepatic impairment group, 8.9% in the moderate hepatic impairment group, and 21.9% in the severe hepatic impairment group, (p = 0.005 for trend). Additionally, the patients with hepatic impairment (n = 109) had higher incidences of episodes of thrombocytopenia (45.9% vs. 8.82%, p < 0.001), hypoalbuminemia (50.5% vs. 11.8%, p < 0.001), new onset of renal dysfunction (16.5% vs. 0.0%, p = 0.011), and electrocardiogram abnormality (28.4% vs. 8.82%, p = 0.019) than the patients without hepatic impairment. Conclusions: The degree of hepatic impairment induced by scrub typhus is associated with new onset of renal dysfunction. KW - hepatic impairment KW - renal dysfunction KW - complication KW - outcome KW - scrub typhus Y1 - 2014 U6 - https://doi.org/10.7754/Clin.Lab.2013.121203 SN - 1433-6510 VL - 60 IS - 1 SP - 63 EP - 68 PB - Clin Lab Publ., Verl. Klinisches Labor CY - Heidelberg ER - TY - JOUR A1 - Sun, Sheng-Yun A1 - Huang, Jin A1 - Meng, Min-Jie A1 - Lu, Jia-Hai A1 - Hocher, Berthold A1 - Liu, Kang-Li A1 - Yang, Qin-He A1 - Zhu, Xiao-Feng T1 - Improvement of lipid profile and reduction of body weight by Shan He Jian Fei Granules in high fat diet-induced obese rats JF - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion N2 - Background: The goal was to study lipid profiles (TG, TC, LDL, HDL), effects on serum leptin, and fat tissue adiponectin, and resistin as well as body weight effects of Shan He Jian Fei Granules (SHJFG) in rats on a high fat diet. Methods: Rats were randomly divided into five groups: normal control group fed with normal fat diet, rats on high fat diet receiving low dosage, middle dosage, high dosage of Shan He Jian Fei Granules (SHJFG) as well as a high fat diet group receiving placebo. Rats were treated for 8 weeks. Body weight and naso-anal length of each rat were recorded and Lee's index was calculated. Serum TG, TC, LDL, HDL and leptin concentrations were analyzed. The gene expressions of adiponectin and resistin in adipose tissues were tested by RT-PCR. Results: Compared to the high-fat diet group, body weights, Lee's indexes, weight of fat tissues and serum TG, TC, LDL and leptin of SHJFG groups significantly decreased (p<0.05), whereas mRNA expressions of adiponectin and resistin of SHJFG groups significantly increased (p<0.05). Conclusions: SHJFG could significantly lower body weight and serum TG, TC, and LDL of obese rats. The effects of SHJFG in lowering leptin synthesis and raising mRNA expression of adiponectin and resistin in fat tissues may act as part of the mechanisms in lowering body weight of obese rats. Further studies are needed to demonstrate whether SHJFG may also reduce overall cardiovascular morbidity and mortality like other lipid lowering drugs. KW - obesity KW - high-fat diet KW - Shan He Jian Fei Granules (SHJFG) KW - lipid KW - adiponectin KW - resistin KW - leptin Y1 - 2012 SN - 1433-6510 VL - 58 IS - 1-2 SP - 81 EP - 87 PB - Clin Lab Publ., Verl. Klinisches Labor CY - Heidelberg ER - TY - JOUR A1 - Peng, Tao A1 - Zhu, Ganghua A1 - Dong, Yunpeng A1 - Zeng, Junjie A1 - Li, Wei A1 - Guo, Weiwei A1 - Chen, Yong A1 - Duan, Maoli A1 - Hocher, Berthold A1 - Xie, Dinghua T1 - BMP4: a possible key factor in differentiation of auditory neuron-like cells from bone-derived mesenchymal stromal cells JF - Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion N2 - Background: Previous studies have shown that BMP4 may play an important part in the development of auditory neurons (ANs), which are degenerated in sensorineural hearing loss. However, whether BMP4 can promote sensory fate specification from mesenchymal stromal cells (MSCs) is unknown so far. Methods: MSCs isolated from Sprague-Dawley (SD) rats were confirmed by expression of MSC markers using flow cytometry and adipogenesis/osteogenesis using differentiation assays. MSCs treated with a complex of neurotrophic factors (BMP4 group and non-BMP4 group) were induced into auditory neuron-like cells, then the differences between the two groups were analyzed in morphological observation, cell growth curve, qRT-PCR, and immunofluorescence. Results: Flow cytometric analysis showed that the isolated cells expressed typical MSC surface markers. After adipogenic and osteogenic induction, the cells were stained by oil red O and Alizarin Red. The neuronal induced cells were in the growth plateau and had special forms of neurons. In the presence of BMP4, the inner ear genes NF-M, Neurog1, GluR4, NeuroD, Calretinin, NeuN, Tau, and GATA3 were up-regulated in MSCs. Conclusions: MSCs have the capacity to differentiate into auditory neuron-like cells in vitro. As an effective inducer, BMP4 may play a key role in transdifferentiation. KW - differentiation KW - auditory neurons KW - BMP4 Y1 - 2015 U6 - https://doi.org/10.7754/Clin.Lab.2015.150217 SN - 1433-6510 VL - 61 IS - 9 SP - 1171 EP - 1178 PB - Clin Lab Publ., Verl. Klinisches Labor CY - Heidelberg ER - TY - JOUR A1 - Stefancu, Andrei A1 - Nan, Lin A1 - Zhu, Li A1 - Chis, Vasile A1 - Bald, Ilko A1 - Liu, Min A1 - Leopold, Nicolae A1 - Maier, Stefan A. A1 - Cortes, Emiliano T1 - Controlling plasmonic chemistry pathways through specific ion effects JF - Advanced optical materials N2 - Plasmon-driven dehalogenation of brominated purines has been recently explored as a model system to understand fundamental aspects of plasmon-assisted chemical reactions. Here, it is shown that divalent Ca2+ ions strongly bridge the adsorption of bromoadenine (Br-Ade) to Ag surfaces. Such ion-mediated binding increases the molecule's adsorption energy leading to an overlap of the metal energy states and the molecular states, enabling the chemical interface damping (CID) of the plasmon modes of the Ag nanostructures (i.e., direct electron transfer from the metal to Br-Ade). Consequently, the conversion of Br-Ade to adenine almost doubles following the addition of Ca2+. These experimental results, supported by theoretical calculations of the local density of states of the Ag/Br-Ade complex, indicate a change of the charge transfer pathway driving the dehalogenation reaction, from Landau damping (in the lack of Ca2+ ions) to CID (after the addition of Ca2+). The results show that the surface dynamics of chemical species (including water molecules) play an essential role in charge transfer at plasmonic interfaces and cannot be ignored. It is envisioned that these results will help in designing more efficient nanoreactors, harnessing the full potential of plasmon-assisted chemistry. KW - chemical interface damping KW - Hofmeister effect KW - hydration layer KW - plasmonic chemistry KW - specific ion effects KW - surface-enhanced Raman scattering Y1 - 2022 U6 - https://doi.org/10.1002/adom.202200397 SN - 2195-1071 VL - 10 IS - 14 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Cook, Katherine V. A1 - Li, Chuang A1 - Cai, Haiyuan A1 - Krumholz, Lee R. A1 - Hambright, K. David A1 - Paerl, Hans W. A1 - Steffen, Morgan M. A1 - Wilson, Alan E. A1 - Burford, Michele A. A1 - Grossart, Hans-Peter A1 - Hamilton, David P. A1 - Jiang, Helong A1 - Sukenik, Assaf A1 - Latour, Delphine A1 - Meyer, Elisabeth I. A1 - Padisak, Judit A1 - Qin, Boqiang A1 - Zamor, Richard M. A1 - Zhu, Guangwei T1 - The global Microcystis interactome JF - Limnology and oceanography N2 - Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs). CyanoHAB species are known to shape bacterial community composition and to rely on functions provided by the associated bacteria, leading to the hypothesized cyanoHAB interactome, a coevolved community of synergistic and interacting bacteria species, each necessary for the success of the others. Here, we surveyed the microbiome associated with Microcystis aeruginosa during blooms in 12 lakes spanning four continents as an initial test of the hypothesized Microcystis interactome. We predicted that microbiome composition and functional potential would be similar across blooms globally. Our results, as revealed by 16S rRNA sequence similarity, indicate that M. aeruginosa is cosmopolitan in lakes across a 280 degrees longitudinal and 90 degrees latitudinal gradient. The microbiome communities were represented by a wide range of operational taxonomic units and relative abundances. Highly abundant taxa were more related and shared across most sites and did not vary with geographic distance, thus, like Microcystis, revealing no evidence for dispersal limitation. High phylogenetic relatedness, both within and across lakes, indicates that microbiome bacteria with similar functional potential were associated with all blooms. While Microcystis and the microbiome bacteria shared many genes, whole-community metagenomic analysis revealed a suite of biochemical pathways that could be considered complementary. Our results demonstrate a high degree of similarity across global Microcystis blooms, thereby providing initial support for the hypothesized Microcystis interactome. Y1 - 2019 U6 - https://doi.org/10.1002/lno.11361 SN - 0024-3590 SN - 1939-5590 VL - 65 SP - S194 EP - S207 PB - Wiley CY - Hoboken ER -