TY - JOUR A1 - Lozano, Yudi M. A1 - Aguilar-Trigueros, Carlos A. A1 - Onandia, Gabriela A1 - Maaß, Stefanie A1 - Zhao, Tingting A1 - Rillig, Matthias C. T1 - Effects of microplastics and drought on soil ecosystem functions and multifunctionality JF - Journal of applied ecology : an official journal of the British Ecological Society N2 - 1. Microplastics in soils have become an important threat for terrestrial systems as they may potentially alter the geochemical/biophysical soil environment and can interact with drought. As microplastics may affect soil water content, this could exacerbate the well-known negative effects of drought on ecosystem functionality. Thus, functions including litter decomposition, soil aggregation or those related with nutrient cycling can be altered. Despite this potential interaction, we know relatively little about how microplastics, under different soil water conditions, affect ecosystem functions and multifunctionality. 2. To address this gap, we performed an experiment using grassland plant communities growing in microcosms. Microplastic fibres (absent, present) and soil water conditions (well-watered, drought) were applied in a fully factorial design. At harvest, we measured soil ecosystem functions related to nutrient cycling (beta-glucosaminidase, beta-D-cellobiosidase, phosphatase, beta-glucosidase enzymes), respiration, nutrient retention, pH, litter decomposition and soil aggregation (water stable aggregates). As terrestrial systems provide these functions simultaneously, we also assessed ecosystem multifunctionality, an index that encompasses the array of ecosystem functions measured here. 3. We found that the interaction between microplastic fibres and drought affected ecosystem functions and multifunctionality. Drought had negatively affected nutrient cycling by decreasing enzymatic activities by up to similar to 39%, while microplastics increased soil aggregation by similar to 18%, soil pH by similar to 4% and nutrient retention by up to similar to 70% by diminishing nutrient leaching. Microplastic fibres also impacted soil enzymes, respiration and ecosystem multifunctionality, but importantly, the direction of these effects depended on soil water status. That is, under well-watered conditions, these functions decreased with microplastic fibres by up to similar to 34% while under drought they had similar values irrespective of the microplastic presence, or tended to increase with microplastics. Litter decomposition had a contrary pattern increasing with microplastics by similar to 6% under well-watered conditions while decreasing to a similar percentage under drought. 4. Synthesis and applications. Single ecosystem functions can be positively or negatively affected by microplastics fibres depending on soil water status. However, our results suggest that microplastic fibres may cause negative effects on ecosystem soil multifunctionality of a similar magnitude as drought. Thus, strategies to counteract this new global change factor are necessary. KW - enzymatic activities KW - grasslands ecosystem KW - litter decomposition KW - nutrient cycling KW - nutrient leaching KW - soil aggregation KW - soil pH KW - soil respiration Y1 - 2021 U6 - https://doi.org/10.1111/1365-2664.13839 SN - 1365-2664 VL - 58 IS - 5 SP - 988 EP - 996 PB - Wiley-Blackwell CY - Oxford [u.a.] ER - TY - JOUR A1 - Nitschke, Felix A1 - Wang, Peixiang A1 - Schmieder, Peter A1 - Girard, Jean-Marie A1 - Awrey, Donald E. A1 - Wang, Tony A1 - Israelian, Johan A1 - Zhao, XiaoChu A1 - Turnbull, Julie A1 - Heydenreich, Matthias A1 - Kleinpeter, Erich A1 - Steup, Martin A1 - Minassian, Berge A. T1 - Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy lafora disease JF - Cell metabolism N2 - Laforin or malin deficiency causes Lafora disease, characterized by altered glycogen metabolism and teenage-onset neurodegeneration with intractable and invariably fatal epilepsy. Plant starches possess small amounts of metabolically essential monophosphate esters. Glycogen contains similar phosphate amounts, which are thought to originate from a glycogen synthase error side reaction and therefore lack any specific function. Glycogen is also believed to lack monophosphates at glucosyl carbon C6, an essential phosphorylation site in plant starch metabolism. We now show that glycogen phosphorylation is not due to a glycogen synthase side reaction, that C6 is a major glycogen phosphorylation site, and that C6 monophosphates predominate near centers of glycogen molecules and positively correlate with glycogen chain lengths. Laforin or malin deficiency causes C6 hyperphosphorylation, which results in malformed long-chained glycogen that accumulates in many tissues, causing neurodegeneration in brain. Our work advances the understanding of Lafora disease pathogenesis and suggests that glycogen phosphorylation has important metabolic function. Y1 - 2013 U6 - https://doi.org/10.1016/j.cmet.2013.04.006 SN - 1550-4131 SN - 1932-7420 VL - 17 IS - 5 SP - 756 EP - 767 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Rothe, Martin A1 - Zhao, Yuhang A1 - Kewes, Günter A1 - Kochovski, Zdravko A1 - Sigle, Wilfried A1 - van Aken, Peter A. A1 - Koch, Christoph A1 - Ballauff, Matthias A1 - Lu, Yan A1 - Benson, Oliver T1 - Silver nanowires with optimized silica coating as versatile plasmonic resonators JF - Scientific reports N2 - Metal nanoparticles are the most frequently used nanostructures in plasmonics. However, besides nanoparticles, metal nanowires feature several advantages for applications. Their elongation offers a larger interaction volume, their resonances can reach higher quality factors, and their mode structure provides better coupling into integrated hybrid dielectric-plasmonic circuits. It is crucial though, to control the distance of the wire to a supporting substrate, to another metal layer or to active materials with sub-nanometer precision. A dielectric coating can be utilized for distance control, but it must not degrade the plasmonic properties. In this paper, we introduce a controlled synthesis and coating approach for silver nanowires to fulfill these demands. We synthesize and characterize silver nanowires of around 70 nm in diameter. These nanowires are coated with nm-sized silica shells using a modified Stober method to achieve a homogeneous and smooth surface quality. We use transmission electron microscopy, dark-field microscopy and electron-energy loss spectroscopy to study morphology and plasmonic resonances of individual nanowires and quantify the influence of the silica coating. Thorough numerical simulations support the experimental findings showing that the coating does not deteriorate the plasmonic properties and thus introduce silver nanowires as usable building blocks for integrated hybrid plasmonic systems. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-019-40380-5 SN - 2045-2322 VL - 9 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Chan, Lili A1 - Chaudhary, Kumardeep A1 - Saha, Aparna A1 - Chauhan, Kinsuk A1 - Vaid, Akhil A1 - Zhao, Shan A1 - Paranjpe, Ishan A1 - Somani, Sulaiman A1 - Richter, Felix A1 - Miotto, Riccardo A1 - Lala, Anuradha A1 - Kia, Arash A1 - Timsina, Prem A1 - Li, Li A1 - Freeman, Robert A1 - Chen, Rong A1 - Narula, Jagat A1 - Just, Allan C. A1 - Horowitz, Carol A1 - Fayad, Zahi A1 - Cordon-Cardo, Carlos A1 - Schadt, Eric A1 - Levin, Matthew A. A1 - Reich, David L. A1 - Fuster, Valentin A1 - Murphy, Barbara A1 - He, John C. A1 - Charney, Alexander W. A1 - Böttinger, Erwin A1 - Glicksberg, Benjamin A1 - Coca, Steven G. A1 - Nadkarni, Girish N. T1 - AKI in hospitalized patients with COVID-19 JF - Journal of the American Society of Nephrology : JASN N2 - Background: Early reports indicate that AKI is common among patients with coronavirus disease 2019 (COVID-19) and associatedwith worse outcomes. However, AKI among hospitalized patients with COVID19 in the United States is not well described. Methods: This retrospective, observational study involved a review of data from electronic health records of patients aged >= 18 years with laboratory-confirmed COVID-19 admitted to the Mount Sinai Health System from February 27 to May 30, 2020. We describe the frequency of AKI and dialysis requirement, AKI recovery, and adjusted odds ratios (aORs) with mortality. Results: Of 3993 hospitalized patients with COVID-19, AKI occurred in 1835 (46%) patients; 347 (19%) of the patientswith AKI required dialysis. The proportionswith stages 1, 2, or 3 AKIwere 39%, 19%, and 42%, respectively. A total of 976 (24%) patients were admitted to intensive care, and 745 (76%) experienced AKI. Of the 435 patients with AKI and urine studies, 84% had proteinuria, 81% had hematuria, and 60% had leukocyturia. Independent predictors of severe AKI were CKD, men, and higher serum potassium at admission. In-hospital mortality was 50% among patients with AKI versus 8% among those without AKI (aOR, 9.2; 95% confidence interval, 7.5 to 11.3). Of survivors with AKI who were discharged, 35% had not recovered to baseline kidney function by the time of discharge. An additional 28 of 77 (36%) patients who had not recovered kidney function at discharge did so on posthospital follow-up. Conclusions: AKI is common among patients hospitalized with COVID-19 and is associated with high mortality. Of all patients with AKI, only 30% survived with recovery of kidney function by the time of discharge. KW - acute renal failure KW - clinical nephrology KW - dialysis KW - COVID-19 Y1 - 2021 U6 - https://doi.org/10.1681/ASN.2020050615 SN - 1046-6673 SN - 1533-3450 VL - 32 IS - 1 SP - 151 EP - 160 PB - American Society of Nephrology CY - Washington ER - TY - GEN A1 - Licht, Alexis A1 - Dupont-Nivet, Guillaume A1 - Pullen, Alex A1 - Kapp, Paul A1 - Abels, Hemmo A. A1 - Lai, Zulong A1 - Guo, ZhaoJie A1 - Abell, Jordan A1 - Giesler, Dominique T1 - Resilience of the Asian atmospheric circulation shown by paleogene dust provenance T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The onset of modern central Asian atmospheric circulation is traditionally linked to the interplay of surface uplift of the Mongolian and Tibetan-Himalayan orogens, retreat of the Paratethys sea from central Asia and Cenozoic global cooling. Although the role of these players has not yet been unravelled, the vast dust deposits of central China support the presence of arid conditions and modern atmospheric pathways for the last 25 million years (Myr). Here, we present provenance data from older (42-33 Myr) dust deposits, at a time when the Tibetan Plateau was less developed, the Paratethys sea still present in central Asia and atmospheric pCO(2) much higher. Our results show that dust sources and near-surface atmospheric circulation have changed little since at least 42 Myr. Our findings indicate that the locus of central Asian high pressures and concurrent aridity is a resilient feature only modulated by mountain building, global cooling and sea retreat. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1114 KW - Chinese Loess Plateau KW - last glacial maximum KW - Tibetan Plateau KW - Yellow-River KW - climate KW - basin KW - evolution KW - ardification KW - monsoons KW - desert Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-436381 SN - 1866-8372 IS - 1114 ER - TY - RPRT A1 - Brodeur, Abel A1 - Mikola, Derek A1 - Cook, Nikolai A1 - Brailey, Thomas A1 - Briggs, Ryan A1 - Gendre, Alexandra de A1 - Dupraz, Yannick A1 - Fiala, Lenka A1 - Gabani, Jacopo A1 - Gauriot, Romain A1 - Haddad, Joanne A1 - Lima, Goncalo A1 - Ankel-Peters, Jörg A1 - Dreber, Anna A1 - Campbell, Douglas A1 - Kattan, Lamis A1 - Fages, Diego Marino A1 - Mierisch, Fabian A1 - Sun, Pu A1 - Wright, Taylor A1 - Connolly, Marie A1 - Hoces de la Guardia, Fernando A1 - Johannesson, Magnus A1 - Miguel, Edward A1 - Vilhuber, Lars A1 - Abarca, Alejandro A1 - Acharya, Mahesh A1 - Adjisse, Sossou Simplice A1 - Akhtar, Ahwaz A1 - Lizardi, Eduardo Alberto Ramirez A1 - Albrecht, Sabina A1 - Andersen, Synve Nygaard A1 - Andlib, Zubaria A1 - Arrora, Falak A1 - Ash, Thomas A1 - Bacher, Etienne A1 - Bachler, Sebastian A1 - Bacon, Félix A1 - Bagues, Manuel A1 - Balogh, Timea A1 - Batmanov, Alisher A1 - Barschkett, Mara A1 - Basdil, B. Kaan A1 - Dower, Jaromneda A1 - Castek, Ondrej A1 - Caviglia-Harris, Jill A1 - Strand, Gabriella Chauca A1 - Chen, Shi A1 - Chzhen, Asya A1 - Chung, Jong A1 - Collins, Jason A1 - Coppock, Alexander A1 - Cordeau, Hugo A1 - Couillard, Ben A1 - Crechet, Jonathan A1 - Crippa, Lorenzo A1 - Cui, Jeanne A1 - Czymara, Christian A1 - Daarstad, Haley A1 - Dao, Danh Chi A1 - Dao, Dong A1 - Schmandt, Marco David A1 - Linde, Astrid de A1 - Melo, Lucas De A1 - Deer, Lachlan A1 - Vera, Micole De A1 - Dimitrova, Velichka A1 - Dollbaum, Jan Fabian A1 - Dollbaum, Jan Matti A1 - Donnelly, Michael A1 - Huynh, Luu Duc Toan A1 - Dumbalska, Tsvetomira A1 - Duncan, Jamie A1 - Duong, Kiet Tuan A1 - Duprey, Thibaut A1 - Dworschak, Christoph A1 - Ellingsrud, Sigmund A1 - Elminejad, Ali A1 - Eissa, Yasmine A1 - Erhart, Andrea A1 - Etingin-Frati, Giulian A1 - Fatemi-Pour, Elaheh A1 - Federice, Alexa A1 - Feld, Jan A1 - Fenig, Guidon A1 - Firouzjaeiangalougah, Mojtaba A1 - Fleisje, Erlend A1 - Fortier-Chouinard, Alexandre A1 - Engel, Julia Francesca A1 - Fries, Tilman A1 - Fortier, Reid A1 - Fréchet, Nadjim A1 - Galipeau, Thomas A1 - Gallegos, Sebastián A1 - Gangji, Areez A1 - Gao, Xiaoying A1 - Garnache, Cloé A1 - Gáspár, Attila A1 - Gavrilova, Evelina A1 - Ghosh, Arijit A1 - Gibney, Garreth A1 - Gibson, Grant A1 - Godager, Geir A1 - Goff, Leonard A1 - Gong, Da A1 - González, Javier A1 - Gretton, Jeremy A1 - Griffa, Cristina A1 - Grigoryeva, Idaliya A1 - Grtting, Maja A1 - Guntermann, Eric A1 - Guo, Jiaqi A1 - Gugushvili, Alexi A1 - Habibnia, Hooman A1 - Häffner, Sonja A1 - Hall, Jonathan D. A1 - Hammar, Olle A1 - Kordt, Amund Hanson A1 - Hashimoto, Barry A1 - Hartley, Jonathan S. A1 - Hausladen, Carina I. A1 - Havránek, Tomáš A1 - Hazen, Jacob A1 - He, Harry A1 - Hepplewhite, Matthew A1 - Herrera-Rodriguez, Mario A1 - Heuer, Felix A1 - Heyes, Anthony A1 - Ho, Anson T. Y. A1 - Holmes, Jonathan A1 - Holzknecht, Armando A1 - Hsu, Yu-Hsiang Dexter A1 - Hu, Shiang-Hung A1 - Huang, Yu-Shiuan A1 - Huebener, Mathias A1 - Huber, Christoph A1 - Huynh, Kim P. A1 - Irsova, Zuzana A1 - Isler, Ozan A1 - Jakobsson, Niklas A1 - Frith, Michael James A1 - Jananji, Raphaël A1 - Jayalath, Tharaka A. A1 - Jetter, Michael A1 - John, Jenny A1 - Forshaw, Rachel Joy A1 - Juan, Felipe A1 - Kadriu, Valon A1 - Karim, Sunny A1 - Kelly, Edmund A1 - Dang, Duy Khanh Hoang A1 - Khushboo, Tazia A1 - Kim, Jin A1 - Kjellsson, Gustav A1 - Kjelsrud, Anders A1 - Kotsadam, Andreas A1 - Korpershoek, Jori A1 - Krashinsky, Lewis A1 - Kundu, Suranjana A1 - Kustov, Alexander A1 - Lalayev, Nurlan A1 - Langlois, Audrée A1 - Laufer, Jill A1 - Lee-Whiting, Blake A1 - Leibing, Andreas A1 - Lenz, Gabriel A1 - Levin, Joel A1 - Li, Peng A1 - Li, Tongzhe A1 - Lin, Yuchen A1 - Listo, Ariel A1 - Liu, Dan A1 - Lu, Xuewen A1 - Lukmanova, Elvina A1 - Luscombe, Alex A1 - Lusher, Lester R. A1 - Lyu, Ke A1 - Ma, Hai A1 - Mäder, Nicolas A1 - Makate, Clifton A1 - Malmberg, Alice A1 - Maitra, Adit A1 - Mandas, Marco A1 - Marcus, Jan A1 - Margaryan, Shushanik A1 - Márk, Lili A1 - Martignano, Andres A1 - Marsh, Abigail A1 - Masetto, Isabella A1 - McCanny, Anthony A1 - McManus, Emma A1 - McWay, Ryan A1 - Metson, Lennard A1 - Kinge, Jonas Minet A1 - Mishra, Sumit A1 - Mohnen, Myra A1 - Möller, Jakob A1 - Montambeault, Rosalie A1 - Montpetit, Sébastien A1 - Morin, Louis-Philippe A1 - Morris, Todd A1 - Moser, Scott A1 - Motoki, Fabio A1 - Muehlenbachs, Lucija A1 - Musulan, Andreea A1 - Musumeci, Marco A1 - Nabin, Munirul A1 - Nchare, Karim A1 - Neubauer, Florian A1 - Nguyen, Quan M. P. A1 - Nguyen, Tuan A1 - Nguyen-Tien, Viet A1 - Niazi, Ali A1 - Nikolaishvili, Giorgi A1 - Nordstrom, Ardyn A1 - Nü, Patrick A1 - Odermatt, Angela A1 - Olson, Matt A1 - ien, Henning A1 - Ölkers, Tim A1 - Vert, Miquel Oliver i. A1 - Oral, Emre A1 - Oswald, Christian A1 - Ousman, Ali A1 - Özak, Ömer A1 - Pandey, Shubham A1 - Pavlov, Alexandre A1 - Pelli, Martino A1 - Penheiro, Romeo A1 - Park, RyuGyung A1 - Martel, Eva Pérez A1 - Petrovičová, Tereza A1 - Phan, Linh A1 - Prettyman, Alexa A1 - Procházka, Jakub A1 - Putri, Aqila A1 - Quandt, Julian A1 - Qiu, Kangyu A1 - Nguyen, Loan Quynh Thi A1 - Rahman, Andaleeb A1 - Rea, Carson H. A1 - Reiremo, Adam A1 - Renée, Laëtitia A1 - Richardson, Joseph A1 - Rivers, Nicholas A1 - Rodrigues, Bruno A1 - Roelofs, William A1 - Roemer, Tobias A1 - Rogeberg, Ole A1 - Rose, Julian A1 - Roskos-Ewoldsen, Andrew A1 - Rosmer, Paul A1 - Sabada, Barbara A1 - Saberian, Soodeh A1 - Salamanca, Nicolas A1 - Sator, Georg A1 - Sawyer, Antoine A1 - Scates, Daniel A1 - Schlüter, Elmar A1 - Sells, Cameron A1 - Sen, Sharmi A1 - Sethi, Ritika A1 - Shcherbiak, Anna A1 - Sogaolu, Moyosore A1 - Soosalu, Matt A1 - Srensen, Erik A1 - Sovani, Manali A1 - Spencer, Noah A1 - Staubli, Stefan A1 - Stans, Renske A1 - Stewart, Anya A1 - Stips, Felix A1 - Stockley, Kieran A1 - Strobel, Stephenson A1 - Struby, Ethan A1 - Tang, John A1 - Tanrisever, Idil A1 - Yang, Thomas Tao A1 - Tastan, Ipek A1 - Tatić, Dejan A1 - Tatlow, Benjamin A1 - Seuyong, Féraud Tchuisseu A1 - Thériault, Rémi A1 - Thivierge, Vincent A1 - Tian, Wenjie A1 - Toma, Filip-Mihai A1 - Totarelli, Maddalena A1 - Tran, Van-Anh A1 - Truong, Hung A1 - Tsoy, Nikita A1 - Tuzcuoglu, Kerem A1 - Ubfal, Diego A1 - Villalobos, Laura A1 - Walterskirchen, Julian A1 - Wang, Joseph Taoyi A1 - Wattal, Vasudha A1 - Webb, Matthew D. A1 - Weber, Bryan A1 - Weisser, Reinhard A1 - Weng, Wei-Chien A1 - Westheide, Christian A1 - White, Kimberly A1 - Winter, Jacob A1 - Wochner, Timo A1 - Woerman, Matt A1 - Wong, Jared A1 - Woodard, Ritchie A1 - Wroński, Marcin A1 - Yazbeck, Myra A1 - Yang, Gustav Chung A1 - Yap, Luther A1 - Yassin, Kareman A1 - Ye, Hao A1 - Yoon, Jin Young A1 - Yurris, Chris A1 - Zahra, Tahreen A1 - Zaneva, Mirela A1 - Zayat, Aline A1 - Zhang, Jonathan A1 - Zhao, Ziwei A1 - Yaolang, Zhong T1 - Mass reproducibility and replicability BT - a new hope T2 - I4R discussion paper series N2 - This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes. KW - conomics KW - open science KW - political science KW - replication KW - reproduction KW - research transparency Y1 - 2024 SN - 2752-1931 IS - 107 PB - Institute for Replication CY - Essen ER -