TY - JOUR A1 - Wuttke, Matthias A1 - Li, Yong A1 - Li, Man A1 - Sieber, Karsten B. A1 - Feitosa, Mary F. A1 - Gorski, Mathias A1 - Tin, Adrienne A1 - Wang, Lihua A1 - Chu, Audrey Y. A1 - Hoppmann, Anselm A1 - Kirsten, Holger A1 - Giri, Ayush A1 - Chai, Jin-Fang A1 - Sveinbjornsson, Gardar A1 - Tayo, Bamidele O. A1 - Nutile, Teresa A1 - Fuchsberger, Christian A1 - Marten, Jonathan A1 - Cocca, Massimiliano A1 - Ghasemi, Sahar A1 - Xu, Yizhe A1 - Horn, Katrin A1 - Noce, Damia A1 - Van der Most, Peter J. A1 - Sedaghat, Sanaz A1 - Yu, Zhi A1 - Akiyama, Masato A1 - Afaq, Saima A1 - Ahluwalia, Tarunveer Singh A1 - Almgren, Peter A1 - Amin, Najaf A1 - Arnlov, Johan A1 - Bakker, Stephan J. L. A1 - Bansal, Nisha A1 - Baptista, Daniela A1 - Bergmann, Sven A1 - Biggs, Mary L. A1 - Biino, Ginevra A1 - Boehnke, Michael A1 - Boerwinkle, Eric A1 - Boissel, Mathilde A1 - Böttinger, Erwin A1 - Boutin, Thibaud S. A1 - Brenner, Hermann A1 - Brumat, Marco A1 - Burkhardt, Ralph A1 - Butterworth, Adam S. A1 - Campana, Eric A1 - Campbell, Archie A1 - Campbell, Harry A1 - Canouil, Mickael A1 - Carroll, Robert J. A1 - Catamo, Eulalia A1 - Chambers, John C. A1 - Chee, Miao-Ling A1 - Chee, Miao-Li A1 - Chen, Xu A1 - Cheng, Ching-Yu A1 - Cheng, Yurong A1 - Christensen, Kaare A1 - Cifkova, Renata A1 - Ciullo, Marina A1 - Concas, Maria Pina A1 - Cook, James P. A1 - Coresh, Josef A1 - Corre, Tanguy A1 - Sala, Cinzia Felicita A1 - Cusi, Daniele A1 - Danesh, John A1 - Daw, E. Warwick A1 - De Borst, Martin H. A1 - De Grandi, Alessandro A1 - De Mutsert, Renee A1 - De Vries, Aiko P. J. A1 - Degenhardt, Frauke A1 - Delgado, Graciela A1 - Demirkan, Ayse A1 - Di Angelantonio, Emanuele A1 - Dittrich, Katalin A1 - Divers, Jasmin A1 - Dorajoo, Rajkumar A1 - Eckardt, Kai-Uwe A1 - Ehret, Georg A1 - Elliott, Paul A1 - Endlich, Karlhans A1 - Evans, Michele K. A1 - Felix, Janine F. A1 - Foo, Valencia Hui Xian A1 - Franco, Oscar H. A1 - Franke, Andre A1 - Freedman, Barry I. A1 - Freitag-Wolf, Sandra A1 - Friedlander, Yechiel A1 - Froguel, Philippe A1 - Gansevoort, Ron T. A1 - Gao, He A1 - Gasparini, Paolo A1 - Gaziano, J. Michael A1 - Giedraitis, Vilmantas A1 - Gieger, Christian A1 - Girotto, Giorgia A1 - Giulianini, Franco A1 - Gogele, Martin A1 - Gordon, Scott D. A1 - Gudbjartsson, Daniel F. A1 - Gudnason, Vilmundur A1 - Haller, Toomas A1 - Hamet, Pavel A1 - Harris, Tamara B. A1 - Hartman, Catharina A. A1 - Hayward, Caroline A1 - Hellwege, Jacklyn N. A1 - Heng, Chew-Kiat A1 - Hicks, Andrew A. A1 - Hofer, Edith A1 - Huang, Wei A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Indridason, Olafur S. A1 - Ingelsson, Erik A1 - Ising, Marcus A1 - Jaddoe, Vincent W. V. A1 - Jakobsdottir, Johanna A1 - Jonas, Jost B. A1 - Joshi, Peter K. A1 - Josyula, Navya Shilpa A1 - Jung, Bettina A1 - Kahonen, Mika A1 - Kamatani, Yoichiro A1 - Kammerer, Candace M. A1 - Kanai, Masahiro A1 - Kastarinen, Mika A1 - Kerr, Shona M. A1 - Khor, Chiea-Chuen A1 - Kiess, Wieland A1 - Kleber, Marcus E. A1 - Koenig, Wolfgang A1 - Kooner, Jaspal S. A1 - Korner, Antje A1 - Kovacs, Peter A1 - Kraja, Aldi T. A1 - Krajcoviechova, Alena A1 - Kramer, Holly A1 - Kramer, Bernhard K. A1 - Kronenberg, Florian A1 - Kubo, Michiaki A1 - Kuhnel, Brigitte A1 - Kuokkanen, Mikko A1 - Kuusisto, Johanna A1 - La Bianca, Martina A1 - Laakso, Markku A1 - Lange, Leslie A. A1 - Langefeld, Carl D. A1 - Lee, Jeannette Jen-Mai A1 - Lehne, Benjamin A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Lim, Su-Chi A1 - Lind, Lars A1 - Lindgren, Cecilia M. A1 - Liu, Jun A1 - Liu, Jianjun A1 - Loeffler, Markus A1 - Loos, Ruth J. F. A1 - Lucae, Susanne A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Magi, Reedik A1 - Magnusson, Patrik K. E. A1 - Mahajan, Anubha A1 - Martin, Nicholas G. A1 - Martins, Jade A1 - Marz, Winfried A1 - Mascalzoni, Deborah A1 - Matsuda, Koichi A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Metspalu, Andres A1 - Mikaelsdottir, Evgenia K. A1 - Milaneschi, Yuri A1 - Miliku, Kozeta A1 - Mishra, Pashupati P. A1 - Program, V. A. Million Veteran A1 - Mohlke, Karen L. A1 - Mononen, Nina A1 - Montgomery, Grant W. A1 - Mook-Kanamori, Dennis O. A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nalls, Mike A. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - Noordam, Raymond A1 - Olafsson, Isleifur A1 - Oldehinkel, Albertine J. A1 - Orho-Melander, Marju A1 - Ouwehand, Willem H. A1 - Padmanabhan, Sandosh A1 - Palmer, Nicholette D. A1 - Palsson, Runolfur A1 - Penninx, Brenda W. J. H. A1 - Perls, Thomas A1 - Perola, Markus A1 - Pirastu, Mario A1 - Pirastu, Nicola A1 - Pistis, Giorgio A1 - Podgornaia, Anna I. A1 - Polasek, Ozren A1 - Ponte, Belen A1 - Porteous, David J. A1 - Poulain, Tanja A1 - Pramstaller, Peter P. A1 - Preuss, Michael H. A1 - Prins, Bram P. A1 - Province, Michael A. A1 - Rabelink, Ton J. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Reilly, Dermot F. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Ridker, Paul M. A1 - Rivadeneira, Fernando A1 - Rizzi, Federica A1 - Roberts, David J. A1 - Robino, Antonietta A1 - Rossing, Peter A1 - Rudan, Igor A1 - Rueedi, Rico A1 - Ruggiero, Daniela A1 - Ryan, Kathleen A. A1 - Saba, Yasaman A1 - Sabanayagam, Charumathi A1 - Salomaa, Veikko A1 - Salvi, Erika A1 - Saum, Kai-Uwe A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Ben Schottker, A1 - Schulz, Christina-Alexandra A1 - Schupf, Nicole A1 - Shaffer, Christian M. A1 - Shi, Yuan A1 - Smith, Albert V. A1 - Smith, Blair H. A1 - Soranzo, Nicole A1 - Spracklen, Cassandra N. A1 - Strauch, Konstantin A1 - Stringham, Heather M. A1 - Stumvoll, Michael A1 - Svensson, Per O. A1 - Szymczak, Silke A1 - Tai, E-Shyong A1 - Tajuddin, Salman M. A1 - Tan, Nicholas Y. Q. A1 - Taylor, Kent D. A1 - Teren, Andrej A1 - Tham, Yih-Chung A1 - Thiery, Joachim A1 - Thio, Chris H. L. A1 - Thomsen, Hauke A1 - Thorleifsson, Gudmar A1 - Toniolo, Daniela A1 - Tonjes, Anke A1 - Tremblay, Johanne A1 - Tzoulaki, Ioanna A1 - Uitterlinden, Andre G. A1 - Vaccargiu, Simona A1 - Van Dam, Rob M. A1 - Van der Harst, Pim A1 - Van Duijn, Cornelia M. A1 - Edward, Digna R. Velez A1 - Verweij, Niek A1 - Vogelezang, Suzanne A1 - Volker, Uwe A1 - Vollenweider, Peter A1 - Waeber, Gerard A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Wang, Ya Xing A1 - Wang, Chaolong A1 - Waterworth, Dawn M. A1 - Bin Wei, Wen A1 - White, Harvey A1 - Whitfield, John B. A1 - Wild, Sarah H. A1 - Wilson, James F. A1 - Wojczynski, Mary K. A1 - Wong, Charlene A1 - Wong, Tien-Yin A1 - Xu, Liang A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Weihua A1 - Zonderman, Alan B. A1 - Rotter, Jerome I. A1 - Bochud, Murielle A1 - Psaty, Bruce M. A1 - Vitart, Veronique A1 - Wilson, James G. A1 - Dehghan, Abbas A1 - Parsa, Afshin A1 - Chasman, Daniel I. A1 - Ho, Kevin A1 - Morris, Andrew P. A1 - Devuyst, Olivier A1 - Akilesh, Shreeram A1 - Pendergrass, Sarah A. A1 - Sim, Xueling A1 - Boger, Carsten A. A1 - Okada, Yukinori A1 - Edwards, Todd L. A1 - Snieder, Harold A1 - Stefansson, Kari A1 - Hung, Adriana M. A1 - Heid, Iris M. A1 - Scholz, Markus A1 - Teumer, Alexander A1 - Kottgen, Anna A1 - Pattaro, Cristian T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals JF - Nature genetics N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research. Y1 - 2019 U6 - https://doi.org/10.1038/s41588-019-0407-x SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 6 SP - 957 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Taal, H. Rob A1 - St Pourcain, Beate A1 - Thiering, Elisabeth A1 - Das, Shikta A1 - Mook-Kanamori, Dennis O. A1 - Warrington, Nicole M. A1 - Kaakinen, Marika A1 - Kreiner-Moller, Eskil A1 - Bradfield, Jonathan P. A1 - Freathy, Rachel M. A1 - Geller, Frank A1 - Guxens, Monica A1 - Cousminer, Diana L. A1 - Kerkhof, Marjan A1 - Timpson, Nicholas J. A1 - Ikram, M. Arfan A1 - Beilin, Lawrence J. A1 - Bonnelykke, Klaus A1 - Buxton, Jessica L. A1 - Charoen, Pimphen A1 - Chawes, Bo Lund Krogsgaard A1 - Eriksson, Johan A1 - Evans, David M. A1 - Hofman, Albert A1 - Kemp, John P. A1 - Kim, Cecilia E. A1 - Klopp, Norman A1 - Lahti, Jari A1 - Lye, Stephen J. A1 - McMahon, George A1 - Mentch, Frank D. A1 - Mueller-Nurasyid, Martina A1 - O'Reilly, Paul F. A1 - Prokopenko, Inga A1 - Rivadeneira, Fernando A1 - Steegers, Eric A. P. A1 - Sunyer, Jordi A1 - Tiesler, Carla A1 - Yaghootkar, Hanieh A1 - Breteler, Monique M. B. A1 - Debette, Stephanie A1 - Fornage, Myriam A1 - Gudnason, Vilmundur A1 - Launer, Lenore J. A1 - van der Lugt, Aad A1 - Mosley, Thomas H. A1 - Seshadri, Sudha A1 - Smith, Albert V. A1 - Vernooij, Meike W. A1 - Blakemore, Alexandra I. F. A1 - Chiavacci, Rosetta M. A1 - Feenstra, Bjarke A1 - Fernandez-Banet, Julio A1 - Grant, Struan F. A. A1 - Hartikainen, Anna-Liisa A1 - van der Heijden, Albert J. A1 - Iniguez, Carmen A1 - Lathrop, Mark A1 - McArdle, Wendy L. A1 - Molgaard, Anne A1 - Newnham, John P. A1 - Palmer, Lyle J. A1 - Palotie, Aarno A1 - Pouta, Annneli A1 - Ring, Susan M. A1 - Sovio, Ulla A1 - Standl, Marie A1 - Uitterlinden, Andre G. A1 - Wichmann, H-Erich A1 - Vissing, Nadja Hawwa A1 - DeCarli, Charles A1 - van Duijn, Cornelia M. A1 - McCarthy, Mark I. A1 - Koppelman, Gerard H. A1 - Estivill, Xavier A1 - Hattersley, Andrew T. A1 - Melbye, Mads A1 - Bisgaard, Hans A1 - Pennell, Craig E. A1 - Widen, Elisabeth A1 - Hakonarson, Hakon A1 - Smith, George Davey A1 - Heinrich, Joachim A1 - Jarvelin, Marjo-Riitta A1 - Jaddoe, Vincent W. V. A1 - Adair, Linda S. A1 - Ang, Wei A1 - Atalay, Mustafa A1 - van Beijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Bradfield, Jonathan P. A1 - Charoen, Pimphen A1 - Coin, Lachlan A1 - Cousminer, Diana L. A1 - Das, Shikta A1 - Davis, Oliver S. P. A1 - Elliott, Paul A1 - Evans, David M. A1 - Feenstra, Bjarke A1 - Flexeder, Claudia A1 - Frayling, Tim A1 - Freathy, Rachel M. A1 - Gaillard, Romy A1 - Geller, Frank A1 - Groen-Blokhuis, Maria A1 - Goh, Liang-Kee A1 - Guxens, Monica A1 - Haworth, Claire M. A. A1 - Hadley, Dexter A1 - Hebebrand, Johannes A1 - Hinney, Anke A1 - Hirschhorn, Joel N. A1 - Holloway, John W. A1 - Holst, Claus A1 - Hottenga, Jouke Jan A1 - Horikoshi, Momoko A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Iniguez, Carmen A1 - Kaakinen, Marika A1 - Kilpelainen, Tuomas O. A1 - Kirin, Mirna A1 - Kowgier, Matthew A1 - Lakka, Hanna-Maaria A1 - Lange, Leslie A. A1 - Lawlor, Debbie A. A1 - Lehtimaki, Terho A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Lindi, Virpi A1 - Maggi, Reedik A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Mook-Kanamori, Dennis O. A1 - Murray, Jeffrey C. A1 - Nivard, Michel A1 - Nohr, Ellen Aagaard A1 - Ntalla, Ioanna A1 - Oken, Emily A1 - O'Reilly, Paul F. A1 - Palmer, Lyle J. A1 - Panoutsopoulou, Kalliope A1 - Pararajasingham, Jennifer A1 - Prokopenko, Inga A1 - Rodriguez, Alina A1 - Salem, Rany M. A1 - Sebert, Sylvain A1 - Siitonen, Niina A1 - Sovio, Ulla A1 - St Pourcain, Beate A1 - Strachan, David P. A1 - Sunyer, Jordi A1 - Taal, H. Rob A1 - Teo, Yik-Ying A1 - Thiering, Elisabeth A1 - Tiesler, Carla A1 - Uitterlinden, Andre G. A1 - Valcarcel, Beatriz A1 - Warrington, Nicole M. A1 - White, Scott A1 - Willemsen, Gonneke A1 - Yaghootkar, Hanieh A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Cooper, Cyrus A1 - Estivill, Xavier A1 - Gillman, Matthew A1 - Grant, Struan F. A. A1 - Hakonarson, Hakon A1 - Hattersley, Andrew T. A1 - Heinrich, Joachim A1 - Hocher, Berthold A1 - Jaddoe, Vincent W. V. A1 - Jarvelin, Marjo-Riitta A1 - Lakka, Timo A. A1 - McCarthy, Mark I. A1 - Melbye, Mads A1 - Mohlke, Karen L. A1 - Dedoussis, George V. A1 - Ong, Ken K. A1 - Pearson, Ewan R. A1 - Pennell, Craig E. A1 - Price, Thomas S. A1 - Power, Chris A1 - Raitakari, Olli T. A1 - Saw, Seang-Mei A1 - Scherag, Andre A1 - Simell, Olli A1 - Sorensen, Thorkild I. A. A1 - Timpson, Nicholas J. A1 - Widen, Elisabeth A1 - Wilson, James F. A1 - Ang, Wei A1 - van Beijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Bradfield, Jonathan P. A1 - Charoen, Pimphen A1 - Coin, Lachlan A1 - Cousminer, Diana L. A1 - Das, Shikta A1 - Elliott, Paul A1 - Evans, David M. A1 - Frayling, Tim A1 - Freathy, Rachel M. A1 - Gaillard, Romy A1 - Groen-Blokhuis, Maria A1 - Guxens, Monica A1 - Hadley, Dexter A1 - Hottenga, Jouke Jan A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Kaakinen, Marika A1 - Kowgier, Matthew A1 - Lawlor, Debbie A. A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Mook-Kanamori, Dennis O. A1 - Nivard, Michel A1 - O'Reilly, Paul F. A1 - Palmer, Lyle J. A1 - Prokopenko, Inga A1 - Rodriguez, Alina A1 - Sebert, Sylvain A1 - Sovio, Ulla A1 - St Pourcain, Beate A1 - Standl, Marie A1 - Strachan, David P. A1 - Sunyer, Jordi A1 - Taal, H. Rob A1 - Thiering, Elisabeth A1 - Tiesler, Carla A1 - Uitterlinden, Andre G. A1 - Valcarcel, Beatriz A1 - Warrington, Nicole M. A1 - White, Scott A1 - Willemsen, Gonneke A1 - Yaghootkar, Hanieh A1 - Boomsma, Dorret I. A1 - Estivill, Xavier A1 - Grant, Struan F. A. A1 - Hakonarson, Hakon A1 - Hattersley, Andrew T. A1 - Heinrich, Joachim A1 - Jaddoe, Vincent W. V. A1 - Jarvelin, Marjo-Riitta A1 - McCarthy, Mark I. A1 - Pennell, Craig E. A1 - Power, Chris A1 - Timpson, Nicholas J. A1 - Widen, Elisabeth A1 - Ikram, M. Arfan A1 - Fornage, Myriam A1 - Smith, Albert V. A1 - Seshadri, Sudha A1 - Schmidt, Reinhold A1 - Debette, Stephanie A1 - Vrooman, Henri A. A1 - Sigurdsson, Sigurdur A1 - Ropele, Stefan A1 - Coker, Laura H. A1 - Longstreth, W. T. A1 - Niessen, Wiro J. A1 - DeStefano, Anita L. A1 - Beiser, Alexa A1 - Zijdenbos, Alex P. A1 - Struchalin, Maksim A1 - Jack, Clifford R. A1 - Nalls, Mike A. A1 - Au, Rhoda A1 - Hofman, Albert A1 - Gudnason, Haukur A1 - van der Lugt, Aad A1 - Harris, Tamara B. A1 - Meeks, William M. A1 - Vernooij, Meike W. A1 - van Buchem, Mark A. A1 - Catellier, Diane A1 - Gudnason, Vilmundur A1 - Windham, B. Gwen A1 - Wolf, Philip A. A1 - van Duijn, Cornelia M. A1 - Mosley, Thomas H. A1 - Schmidt, Helena A1 - Launer, Lenore J. A1 - Breteler, Monique M. B. A1 - DeCarli, Charles T1 - Common variants at 12q15 and 12q24 are associated with infant head circumference JF - Nature genetics N2 - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. Y1 - 2012 U6 - https://doi.org/10.1038/ng.2238 SN - 1061-4036 VL - 44 IS - 5 SP - 532 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Middeldorp, Christel M. A1 - Mahajan, Anubha A1 - Horikoshi, Momoko A1 - Robertson, Neil R. A1 - Beaumont, Robin N. A1 - Bradfield, Jonathan P. A1 - Bustamante, Mariona A1 - Cousminer, Diana L. A1 - Day, Felix R. A1 - De Silva, N. Maneka A1 - Guxens, Monica A1 - Mook-Kanamori, Dennis O. A1 - St Pourcain, Beate A1 - Warrington, Nicole M. A1 - Adair, Linda S. A1 - Ahlqvist, Emma A1 - Ahluwalia, Tarunveer Singh A1 - Almgren, Peter A1 - Ang, Wei A1 - Atalay, Mustafa A1 - Auvinen, Juha A1 - Bartels, Meike A1 - Beckmann, Jacques S. A1 - Bilbao, Jose Ramon A1 - Bond, Tom A1 - Borja, Judith B. A1 - Cavadino, Alana A1 - Charoen, Pimphen A1 - Chen, Zhanghua A1 - Coin, Lachlan A1 - Cooper, Cyrus A1 - Curtin, John A. A1 - Custovic, Adnan A1 - Das, Shikta A1 - Davies, Gareth E. A1 - Dedoussis, George V. A1 - Duijts, Liesbeth A1 - Eastwood, Peter R. A1 - Eliasen, Anders U. A1 - Elliott, Paul A1 - Eriksson, Johan G. A1 - Estivill, Xavier A1 - Fadista, Joao A1 - Fedko, Iryna O. A1 - Frayling, Timothy M. A1 - Gaillard, Romy A1 - Gauderman, W. James A1 - Geller, Frank A1 - Gilliland, Frank A1 - Gilsanz, Vincente A1 - Granell, Raquel A1 - Grarup, Niels A1 - Groop, Leif A1 - Hadley, Dexter A1 - Hakonarson, Hakon A1 - Hansen, Torben A1 - Hartman, Catharina A. A1 - Hattersley, Andrew T. A1 - Hayes, M. Geoffrey A1 - Hebebrand, Johannes A1 - Heinrich, Joachim A1 - Helgeland, Oyvind A1 - Henders, Anjali K. A1 - Henderson, John A1 - Henriksen, Tine B. A1 - Hirschhorn, Joel N. A1 - Hivert, Marie-France A1 - Hocher, Berthold A1 - Holloway, John W. A1 - Holt, Patrick A1 - Hottenga, Jouke-Jan A1 - Hypponen, Elina A1 - Iniguez, Carmen A1 - Johansson, Stefan A1 - Jugessur, Astanand A1 - Kahonen, Mika A1 - Kalkwarf, Heidi J. A1 - Kaprio, Jaakko A1 - Karhunen, Ville A1 - Kemp, John P. A1 - Kerkhof, Marjan A1 - Koppelman, Gerard H. A1 - Korner, Antje A1 - Kotecha, Sailesh A1 - Kreiner-Moller, Eskil A1 - Kulohoma, Benard A1 - Kumar, Ashish A1 - Kutalik, Zoltan A1 - Lahti, Jari A1 - Lappe, Joan M. A1 - Larsson, Henrik A1 - Lehtimaki, Terho A1 - Lewin, Alexandra M. A1 - Li, Jin A1 - Lichtenstein, Paul A1 - Lindgren, Cecilia M. A1 - Lindi, Virpi A1 - Linneberg, Allan A1 - Liu, Xueping A1 - Liu, Jun A1 - Lowe, William L. A1 - Lundstrom, Sebastian A1 - Lyytikainen, Leo-Pekka A1 - Ma, Ronald C. W. A1 - Mace, Aurelien A1 - Magi, Reedik A1 - Magnus, Per A1 - Mamun, Abdullah A. A1 - Mannikko, Minna A1 - Martin, Nicholas G. A1 - Mbarek, Hamdi A1 - McCarthy, Nina S. A1 - Medland, Sarah E. A1 - Melbye, Mads A1 - Melen, Erik A1 - Mohlke, Karen L. A1 - Monnereau, Claire A1 - Morgen, Camilla S. A1 - Morris, Andrew P. A1 - Murray, Jeffrey C. A1 - Myhre, Ronny A1 - Najman, Jackob M. A1 - Nivard, Michel G. A1 - Nohr, Ellen A. A1 - Nolte, Ilja M. A1 - Ntalla, Ioanna A1 - Oberfield, Sharon E. A1 - Oken, Emily A1 - Oldehinkel, Albertine J. A1 - Pahkala, Katja A1 - Palviainen, Teemu A1 - Panoutsopoulou, Kalliope A1 - Pedersen, Oluf A1 - Pennell, Craig E. A1 - Pershagen, Goran A1 - Pitkanen, Niina A1 - Plomin, Robert A1 - Power, Christine A1 - Prasad, Rashmi B. A1 - Prokopenko, Inga A1 - Pulkkinen, Lea A1 - Raikkonen, Katri A1 - Raitakari, Olli T. A1 - Reynolds, Rebecca M. A1 - Richmond, Rebecca C. A1 - Rivadeneira, Fernando A1 - Rodriguez, Alina A1 - Rose, Richard J. A1 - Salem, Rany A1 - Santa-Marina, Loreto A1 - Saw, Seang-Mei A1 - Schnurr, Theresia M. A1 - Scott, James G. A1 - Selzam, Saskia A1 - Shepherd, John A. A1 - Simpson, Angela A1 - Skotte, Line A1 - Sleiman, Patrick M. A. A1 - Snieder, Harold A1 - Sorensen, Thorkild I. A. A1 - Standl, Marie A1 - Steegers, Eric A. P. A1 - Strachan, David P. A1 - Straker, Leon A1 - Strandberg, Timo A1 - Taylor, Michelle A1 - Teo, Yik-Ying A1 - Thiering, Elisabeth A1 - Torrent, Maties A1 - Tyrrell, Jessica A1 - Uitterlinden, Andre G. A1 - van Beijsterveldt, Toos A1 - van der Most, Peter J. A1 - van Duijn, Cornelia M. A1 - Viikari, Jorma A1 - Vilor-Tejedor, Natalia A1 - Vogelezang, Suzanne A1 - Vonk, Judith M. A1 - Vrijkotte, Tanja G. M. A1 - Vuoksimaa, Eero A1 - Wang, Carol A. A1 - Watkins, William J. A1 - Wichmann, H-Erich A1 - Willemsen, Gonneke A1 - Williams, Gail M. A1 - Wilson, James F. A1 - Wray, Naomi R. A1 - Xu, Shujing A1 - Xu, Cheng-Jian A1 - Yaghootkar, Hanieh A1 - Yi, Lu A1 - Zafarmand, Mohammad Hadi A1 - Zeggini, Eleftheria A1 - Zemel, Babette S. A1 - Hinney, Anke A1 - Lakka, Timo A. A1 - Whitehouse, Andrew J. O. A1 - Sunyer, Jordi A1 - Widen, Elisabeth E. A1 - Feenstra, Bjarke A1 - Sebert, Sylvain A1 - Jacobsson, Bo A1 - Njolstad, Pal R. A1 - Stoltenberg, Camilla A1 - Smith, George Davey A1 - Lawlor, Debbie A. A1 - Paternoster, Lavinia A1 - Timpson, Nicholas J. A1 - Ong, Ken K. A1 - Bisgaard, Hans A1 - Bonnelykke, Klaus A1 - Jaddoe, Vincent W. V. A1 - Tiemeier, Henning A1 - Jarvelin, Marjo-Riitta A1 - Evans, David M. A1 - Perry, John R. B. A1 - Grant, Struan F. A. A1 - Boomsma, Dorret I. A1 - Freathy, Rachel M. A1 - McCarthy, Mark I. A1 - Felix, Janine F. T1 - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia BT - design, results and future prospects JF - European journal of epidemiology N2 - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites. KW - Genetics KW - Consortium KW - Childhood traits and disorders KW - Longitudinal Y1 - 2019 U6 - https://doi.org/10.1007/s10654-019-00502-9 SN - 0393-2990 SN - 1573-7284 VL - 34 IS - 3 SP - 279 EP - 300 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Warrington, Nicole A1 - Beaumont, Robin A1 - Horikoshi, Momoko A1 - Day, Felix R. A1 - Helgeland, Øyvind A1 - Laurin, Charles A1 - Bacelis, Jonas A1 - Peng, Shouneng A1 - Hao, Ke A1 - Feenstra, Bjarke A1 - Wood, Andrew R. A1 - Mahajan, Anubha A1 - Tyrrell, Jessica A1 - Robertson, Neil R. A1 - Rayner, N. William A1 - Qiao, Zhen A1 - Moen, Gunn-Helen A1 - Vaudel, Marc A1 - Marsit, Carmen A1 - Chen, Jia A1 - Nodzenski, Michael A1 - Schnurr, Theresia M. A1 - Zafarmand, Mohammad Hadi A1 - Bradfield, Jonathan P. A1 - Grarup, Niels A1 - Kooijman, Marjolein N. A1 - Li-Gao, Ruifang A1 - Geller, Frank A1 - Ahluwalia, Tarunveer Singh A1 - Paternoster, Lavinia A1 - Rueedi, Rico A1 - Huikari, Ville A1 - Hottenga, Jouke-Jan A1 - Lyytikäinen, Leo-Pekka A1 - Cavadino, Alana A1 - Metrustry, Sarah A1 - Cousminer, Diana L. A1 - Wu, Ying A1 - Thiering, Elisabeth Paula A1 - Wang, Carol A. A1 - Have, Christian Theil A1 - Vilor-Tejedor, Natalia A1 - Joshi, Peter K. A1 - Painter, Jodie N. A1 - Ntalla, Ioanna A1 - Myhre, Ronny A1 - Pitkänen, Niina A1 - van Leeuwen, Elisabeth M. A1 - Joro, Raimo A1 - Lagou, Vasiliki A1 - Richmond, Rebecca C. A1 - Espinosa, Ana A1 - Barton, Sheila J. A1 - Inskip, Hazel M. A1 - Holloway, John W. A1 - Santa-Marina, Loreto A1 - Estivill, Xavier A1 - Ang, Wei A1 - Marsh, Julie A. A1 - Reichetzeder, Christoph A1 - Marullo, Letizia A1 - Hocher, Berthold A1 - Lunetta, Kathryn L. A1 - Murabito, Joanne M. A1 - Relton, Caroline L. A1 - Kogevinas, Manolis A1 - Chatzi, Leda A1 - Allard, Catherine A1 - Bouchard, Luigi A1 - Hivert, Marie-France A1 - Zhang, Ge A1 - Muglia, Louis J. A1 - Heikkinen, Jani A1 - Morgen, Camilla S. A1 - van Kampen, Antoine H. C. A1 - van Schaik, Barbera D. C. A1 - Mentch, Frank D. A1 - Langenberg, Claudia A1 - Scott, Robert A. A1 - Zhao, Jing Hua A1 - Hemani, Gibran A1 - Ring, Susan M. A1 - Bennett, Amanda J. A1 - Gaulton, Kyle J. A1 - Fernandez-Tajes, Juan A1 - van Zuydam, Natalie R. A1 - Medina-Gomez, Carolina A1 - de Haan, Hugoline G. A1 - Rosendaal, Frits R. A1 - Kutalik, Zoltán A1 - Marques-Vidal, Pedro A1 - Das, Shikta A1 - Willemsen, Gonneke A1 - Mbarek, Hamdi A1 - Müller-Nurasyid, Martina A1 - Standl, Marie A1 - Appel, Emil V. R. A1 - Fonvig, Cilius Esmann A1 - Trier, Caecilie A1 - van Beijsterveldt, Catharina E. M. A1 - Murcia, Mario A1 - Bustamante, Mariona A1 - Bonàs-Guarch, Sílvia A1 - Hougaard, David M. A1 - Mercader, Josep M. A1 - Linneberg, Allan A1 - Schraut, Katharina E. A1 - Lind, Penelope A. A1 - Medland, Sarah Elizabeth A1 - Shields, Beverley M. A1 - Knight, Bridget A. A1 - Chai, Jin-Fang A1 - Panoutsopoulou, Kalliope A1 - Bartels, Meike A1 - Sánchez, Friman A1 - Stokholm, Jakob A1 - Torrents, David A1 - Vinding, Rebecca K. A1 - Willems, Sara M. A1 - Atalay, Mustafa A1 - Chawes, Bo L. A1 - Kovacs, Peter A1 - Prokopenko, Inga A1 - Tuke, Marcus A. A1 - Yaghootkar, Hanieh A1 - Ruth, Katherine S. A1 - Jones, Samuel E. A1 - Loh, Po-Ru A1 - Murray, Anna A1 - Weedon, Michael N. A1 - Tönjes, Anke A1 - Stumvoll, Michael A1 - Michaelsen, Kim Fleischer A1 - Eloranta, Aino-Maija A1 - Lakka, Timo A. A1 - van Duijn, Cornelia M. A1 - Kiess, Wieland A1 - Koerner, Antje A1 - Niinikoski, Harri A1 - Pahkala, Katja A1 - Raitakari, Olli T. A1 - Jacobsson, Bo A1 - Zeggini, Eleftheria A1 - Dedoussis, George V. A1 - Teo, Yik-Ying A1 - Saw, Seang-Mei A1 - Montgomery, Grant W. A1 - Campbell, Harry A1 - Wilson, James F. A1 - Vrijkotte, Tanja G. M. A1 - Vrijheid, Martine A1 - de Geus, Eco J. C. N. A1 - Hayes, M. Geoffrey A1 - Kadarmideen, Haja N. A1 - Holm, Jens-Christian A1 - Beilin, Lawrence J. A1 - Pennell, Craig E. A1 - Heinrich, Joachim A1 - Adair, Linda S. A1 - Borja, Judith B. A1 - Mohlke, Karen L. A1 - Eriksson, Johan G. A1 - Widen, Elisabeth E. A1 - Hattersley, Andrew T. A1 - Spector, Tim D. A1 - Kaehoenen, Mika A1 - Viikari, Jorma S. A1 - Lehtimaeki, Terho A1 - Boomsma, Dorret I. A1 - Sebert, Sylvain A1 - Vollenweider, Peter A1 - Sorensen, Thorkild I. A. A1 - Bisgaard, Hans A1 - Bonnelykke, Klaus A1 - Murray, Jeffrey C. A1 - Melbye, Mads A1 - Nohr, Ellen A. A1 - Mook-Kanamori, Dennis O. A1 - Rivadeneira, Fernando A1 - Hofman, Albert A1 - Felix, Janine F. A1 - Jaddoe, Vincent W. V. A1 - Hansen, Torben A1 - Pisinger, Charlotta A1 - Vaag, Allan A. A1 - Pedersen, Oluf A1 - Uitterlinden, Andre G. A1 - Jarvelin, Marjo-Riitta A1 - Power, Christine A1 - Hypponen, Elina A1 - Scholtens, Denise M. A1 - Lowe, William L. A1 - Smith, George Davey A1 - Timpson, Nicholas J. A1 - Morris, Andrew P. A1 - Wareham, Nicholas J. A1 - Hakonarson, Hakon A1 - Grant, Struan F. A. A1 - Frayling, Timothy M. A1 - Lawlor, Debbie A. A1 - Njolstad, Pal R. A1 - Johansson, Stefan A1 - Ong, Ken K. A1 - McCarthy, Mark I. A1 - Perry, John R. B. A1 - Evans, David M. A1 - Freathy, Rachel M. T1 - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors JF - Nature genetics N2 - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming. Y1 - 2019 SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 5 SP - 804 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Horikoshi, Momoko A1 - Yaghootkar, Hanieh A1 - Mook-Kanamori, Dennis O. A1 - Sovio, Ulla A1 - Taal, H. Rob A1 - Hennig, Branwen J. A1 - Bradfield, Jonathan P. A1 - St Pourcain, Beate A1 - Evans, David M. A1 - Charoen, Pimphen A1 - Kaakinen, Marika A1 - Cousminer, Diana L. A1 - Lehtimaki, Terho A1 - Kreiner-Moller, Eskil A1 - Warrington, Nicole M. A1 - Bustamante, Mariona A1 - Feenstra, Bjarke A1 - Berry, Diane J. A1 - Thiering, Elisabeth A1 - Pfab, Thiemo A1 - Barton, Sheila J. A1 - Shields, Beverley M. A1 - Kerkhof, Marjan A1 - van Leeuwen, Elisabeth M. A1 - Fulford, Anthony J. A1 - Kutalik, Zoltan A1 - Zhao, Jing Hua A1 - den Hoed, Marcel A1 - Mahajan, Anubha A1 - Lindi, Virpi A1 - Goh, Liang-Kee A1 - Hottenga, Jouke-Jan A1 - Wu, Ying A1 - Raitakari, Olli T. A1 - Harder, Marie N. A1 - Meirhaeghe, Aline A1 - Ntalla, Ioanna A1 - Salem, Rany M. A1 - Jameson, Karen A. A1 - Zhou, Kaixin A1 - Monies, Dorota M. A1 - Lagou, Vasiliki A1 - Kirin, Mirna A1 - Heikkinen, Jani A1 - Adair, Linda S. A1 - Alkuraya, Fowzan S. A1 - Al-Odaib, Ali A1 - Amouyel, Philippe A1 - Andersson, Ehm Astrid A1 - Bennett, Amanda J. A1 - Blakemore, Alexandra I. F. A1 - Buxton, Jessica L. A1 - Dallongeville, Jean A1 - Das, Shikta A1 - de Geus, Eco J. C. A1 - Estivill, Xavier A1 - Flexeder, Claudia A1 - Froguel, Philippe A1 - Geller, Frank A1 - Godfrey, Keith M. A1 - Gottrand, Frederic A1 - Groves, Christopher J. A1 - Hansen, Torben A1 - Hirschhorn, Joel N. A1 - Hofman, Albert A1 - Hollegaard, Mads V. A1 - Hougaard, David M. A1 - Hyppoenen, Elina A1 - Inskip, Hazel M. A1 - Isaacs, Aaron A1 - Jorgensen, Torben A1 - Kanaka-Gantenbein, Christina A1 - Kemp, John P. A1 - Kiess, Wieland A1 - Kilpelainen, Tuomas O. A1 - Klopp, Norman A1 - Knight, Bridget A. A1 - Kuzawa, Christopher W. A1 - McMahon, George A1 - Newnham, John P. A1 - Niinikoski, Harri A1 - Oostra, Ben A. A1 - Pedersen, Louise A1 - Postma, Dirkje S. A1 - Ring, Susan M. A1 - Rivadeneira, Fernando A1 - Robertson, Neil R. A1 - Sebert, Sylvain A1 - Simell, Olli A1 - Slowinski, Torsten A1 - Tiesler, Carla M. T. A1 - Toenjes, Anke A1 - Vaag, Allan A1 - Viikari, Jorma S. A1 - Vink, Jacqueline M. A1 - Vissing, Nadja Hawwa A1 - Wareham, Nicholas J. A1 - Willemsen, Gonneke A1 - Witte, Daniel R. A1 - Zhang, Haitao A1 - Zhao, Jianhua A1 - Wilson, James F. A1 - Stumvoll, Michael A1 - Prentice, Andrew M. A1 - Meyer, Brian F. A1 - Pearson, Ewan R. A1 - Boreham, Colin A. G. A1 - Cooper, Cyrus A1 - Gillman, Matthew W. A1 - Dedoussis, George V. A1 - Moreno, Luis A. A1 - Pedersen, Oluf A1 - Saarinen, Maiju A1 - Mohlke, Karen L. A1 - Boomsma, Dorret I. A1 - Saw, Seang-Mei A1 - Lakka, Timo A. A1 - Koerner, Antje A1 - Loos, Ruth J. F. A1 - Ong, Ken K. A1 - Vollenweider, Peter A1 - van Duijn, Cornelia M. A1 - Koppelman, Gerard H. A1 - Hattersley, Andrew T. A1 - Holloway, John W. A1 - Hocher, Berthold A1 - Heinrich, Joachim A1 - Power, Chris A1 - Melbye, Mads A1 - Guxens, Monica A1 - Pennell, Craig E. A1 - Bonnelykke, Klaus A1 - Bisgaard, Hans A1 - Eriksson, Johan G. A1 - Widen, Elisabeth A1 - Hakonarson, Hakon A1 - Uitterlinden, Andre G. A1 - Pouta, Anneli A1 - Lawlor, Debbie A. A1 - Smith, George Davey A1 - Frayling, Timothy M. A1 - McCarthy, Mark I. A1 - Grant, Struan F. A. A1 - Jaddoe, Vincent W. V. A1 - Jarvelin, Marjo-Riitta A1 - Timpson, Nicholas J. A1 - Prokopenko, Inga A1 - Freathy, Rachel M. T1 - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism JF - Nature genetics N2 - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. Y1 - 2013 U6 - https://doi.org/10.1038/ng.2477 SN - 1061-4036 VL - 45 IS - 1 SP - 76 EP - U115 PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Arridge, Christopher S. A1 - Achilleos, N. A1 - Agarwal, Jessica A1 - Agnor, C. B. A1 - Ambrosi, R. A1 - Andre, N. A1 - Badman, S. V. A1 - Baines, K. A1 - Banfield, D. A1 - Barthelemy, M. A1 - Bisi, M. M. A1 - Blum, J. A1 - Bocanegra-Bahamon, T. A1 - Bonfond, B. A1 - Bracken, C. A1 - Brandt, P. A1 - Briand, C. A1 - Briois, C. A1 - Brooks, S. A1 - Castillo-Rogez, J. A1 - Cavalie, T. A1 - Christophe, B. A1 - Coates, Andrew J. A1 - Collinson, G. A1 - Cooper, John F. A1 - Costa-Sitja, M. A1 - Courtin, R. A1 - Daglis, I. A. A1 - De Pater, Imke A1 - Desai, M. A1 - Dirkx, D. A1 - Dougherty, M. K. A1 - Ebert, R. W. A1 - Filacchione, Gianrico A1 - Fletcher, Leigh N. A1 - Fortney, J. A1 - Gerth, I. A1 - Grassi, D. A1 - Grodent, D. A1 - Grün, Eberhard A1 - Gustin, J. A1 - Hedman, M. A1 - Helled, R. A1 - Henri, P. A1 - Hess, Sebastien A1 - Hillier, J. K. A1 - Hofstadter, M. H. A1 - Holme, R. A1 - Horanyi, M. A1 - Hospodarsky, George B. A1 - Hsu, S. A1 - Irwin, P. A1 - Jackman, C. M. A1 - Karatekin, O. A1 - Kempf, Sascha A1 - Khalisi, E. A1 - Konstantinidis, K. A1 - Kruger, H. A1 - Kurth, William S. A1 - Labrianidis, C. A1 - Lainey, V. A1 - Lamy, L. L. A1 - Laneuville, Matthieu A1 - Lucchesi, D. A1 - Luntzer, A. A1 - MacArthur, J. A1 - Maier, A. A1 - Masters, A. A1 - McKenna-Lawlor, S. A1 - Melin, H. A1 - Milillo, A. A1 - Moragas-Klostermeyer, Georg A1 - Morschhauser, Achim A1 - Moses, J. I. A1 - Mousis, O. A1 - Nettelmann, N. A1 - Neubauer, F. M. A1 - Nordheim, T. A1 - Noyelles, B. A1 - Orton, G. S. A1 - Owens, Mathew A1 - Peron, R. A1 - Plainaki, C. A1 - Postberg, F. A1 - Rambaux, N. A1 - Retherford, K. A1 - Reynaud, Serge A1 - Roussos, Elias A1 - Russell, C. T. A1 - Rymer, Am. A1 - Sallantin, R. A1 - Sanchez-Lavega, A. A1 - Santolik, O. A1 - Saur, J. A1 - Sayanagi, Km. A1 - Schenk, P. A1 - Schubert, J. A1 - Sergis, N. A1 - Sittler, E. C. A1 - Smith, A. A1 - Spahn, Frank A1 - Srama, Ralf A1 - Stallard, T. A1 - Sterken, V. A1 - Sternovsky, Zoltan A1 - Tiscareno, M. A1 - Tobie, G. A1 - Tosi, F. A1 - Trieloff, M. A1 - Turrini, D. A1 - Turtle, E. P. A1 - Vinatier, S. A1 - Wilson, R. A1 - Zarkat, P. T1 - The science case for an orbital mission to Uranus: Exploring the origins and evolution of ice giant planets JF - Planetary and space science N2 - Giant planets helped to shape the conditions we see in the Solar System today and they account for more than 99% of the mass of the Sun's planetary system. They can be subdivided into the Ice Giants (Uranus and Neptune) and the Gas Giants (Jupiter and Saturn), which differ from each other in a number of fundamental ways. Uranus, in particular is the most challenging to our understanding of planetary formation and evolution, with its large obliquity, low self-luminosity, highly asymmetrical internal field, and puzzling internal structure. Uranus also has a rich planetary system consisting of a system of inner natural satellites and complex ring system, five major natural icy satellites, a system of irregular moons with varied dynamical histories, and a highly asymmetrical magnetosphere. Voyager 2 is the only spacecraft to have explored Uranus, with a flyby in 1986, and no mission is currently planned to this enigmatic system. However, a mission to the uranian system would open a new window on the origin and evolution of the Solar System and would provide crucial information on a wide variety of physicochemical processes in our Solar System. These have clear implications for understanding exoplanetary systems. In this paper we describe the science case for an orbital mission to Uranus with an atmospheric entry probe to sample the composition and atmospheric physics in Uranus' atmosphere. The characteristics of such an orbiter and a strawman scientific payload are described and we discuss the technical challenges for such a mission. This paper is based on a white paper submitted to the European Space Agency's call for science themes for its large-class mission programme in 2013. KW - Uranus KW - Magnetosphere KW - Atmosphere KW - Natural satellites KW - Rings KW - Planetary interior Y1 - 2014 U6 - https://doi.org/10.1016/j.pss.2014.08.009 SN - 0032-0633 VL - 104 SP - 122 EP - 140 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Tiegs, Scott D. A1 - Costello, David M. A1 - Isken, Mark W. A1 - Woodward, Guy A1 - McIntyre, Peter B. A1 - Gessner, Mark O. A1 - Chauvet, Eric A1 - Griffiths, Natalie A. A1 - Flecker, Alex S. A1 - Acuna, Vicenc A1 - Albarino, Ricardo A1 - Allen, Daniel C. A1 - Alonso, Cecilia A1 - Andino, Patricio A1 - Arango, Clay A1 - Aroviita, Jukka A1 - Barbosa, Marcus V. M. A1 - Barmuta, Leon A. A1 - Baxter, Colden V. A1 - Bell, Thomas D. C. A1 - Bellinger, Brent A1 - Boyero, Luz A1 - Brown, Lee E. A1 - Bruder, Andreas A1 - Bruesewitz, Denise A. A1 - Burdon, Francis J. A1 - Callisto, Marcos A1 - Canhoto, Cristina A1 - Capps, Krista A. A1 - Castillo, Maria M. A1 - Clapcott, Joanne A1 - Colas, Fanny A1 - Colon-Gaud, Checo A1 - Cornut, Julien A1 - Crespo-Perez, Veronica A1 - Cross, Wyatt F. A1 - Culp, Joseph M. A1 - Danger, Michael A1 - Dangles, Olivier A1 - de Eyto, Elvira A1 - Derry, Alison M. A1 - Diaz Villanueva, Veronica A1 - Douglas, Michael M. A1 - Elosegi, Arturo A1 - Encalada, Andrea C. A1 - Entrekin, Sally A1 - Espinosa, Rodrigo A1 - Ethaiya, Diana A1 - Ferreira, Veronica A1 - Ferriol, Carmen A1 - Flanagan, Kyla M. A1 - Fleituch, Tadeusz A1 - Shah, Jennifer J. Follstad A1 - Frainer, Andre A1 - Friberg, Nikolai A1 - Frost, Paul C. A1 - Garcia, Erica A. A1 - Lago, Liliana Garcia A1 - Garcia Soto, Pavel Ernesto A1 - Ghate, Sudeep A1 - Giling, Darren P. A1 - Gilmer, Alan A1 - Goncalves, Jose Francisco A1 - Gonzales, Rosario Karina A1 - Graca, Manuel A. S. A1 - Grace, Mike A1 - Grossart, Hans-Peter A1 - Guerold, Francois A1 - Gulis, Vlad A1 - Hepp, Luiz U. A1 - Higgins, Scott A1 - Hishi, Takuo A1 - Huddart, Joseph A1 - Hudson, John A1 - Imberger, Samantha A1 - Iniguez-Armijos, Carlos A1 - Iwata, Tomoya A1 - Janetski, David J. A1 - Jennings, Eleanor A1 - Kirkwood, Andrea E. A1 - Koning, Aaron A. A1 - Kosten, Sarian A1 - Kuehn, Kevin A. A1 - Laudon, Hjalmar A1 - Leavitt, Peter R. A1 - Lemes da Silva, Aurea L. A1 - Leroux, Shawn J. A1 - Leroy, Carri J. A1 - Lisi, Peter J. A1 - MacKenzie, Richard A1 - Marcarelli, Amy M. A1 - Masese, Frank O. A1 - Mckie, Brendan G. A1 - Oliveira Medeiros, Adriana A1 - Meissner, Kristian A1 - Milisa, Marko A1 - Mishra, Shailendra A1 - Miyake, Yo A1 - Moerke, Ashley A1 - Mombrikotb, Shorok A1 - Mooney, Rob A1 - Moulton, Tim A1 - Muotka, Timo A1 - Negishi, Junjiro N. A1 - Neres-Lima, Vinicius A1 - Nieminen, Mika L. A1 - Nimptsch, Jorge A1 - Ondruch, Jakub A1 - Paavola, Riku A1 - Pardo, Isabel A1 - Patrick, Christopher J. A1 - Peeters, Edwin T. H. M. A1 - Pozo, Jesus A1 - Pringle, Catherine A1 - Prussian, Aaron A1 - Quenta, Estefania A1 - Quesada, Antonio A1 - Reid, Brian A1 - Richardson, John S. A1 - Rigosi, Anna A1 - Rincon, Jose A1 - Risnoveanu, Geta A1 - Robinson, Christopher T. A1 - Rodriguez-Gallego, Lorena A1 - Royer, Todd V. A1 - Rusak, James A. A1 - Santamans, Anna C. A1 - Selmeczy, Geza B. A1 - Simiyu, Gelas A1 - Skuja, Agnija A1 - Smykla, Jerzy A1 - Sridhar, Kandikere R. A1 - Sponseller, Ryan A1 - Stoler, Aaron A1 - Swan, Christopher M. A1 - Szlag, David A1 - Teixeira-de Mello, Franco A1 - Tonkin, Jonathan D. A1 - Uusheimo, Sari A1 - Veach, Allison M. A1 - Vilbaste, Sirje A1 - Vought, Lena B. M. A1 - Wang, Chiao-Ping A1 - Webster, Jackson R. A1 - Wilson, Paul B. A1 - Woelfl, Stefan A1 - Xenopoulos, Marguerite A. A1 - Yates, Adam G. A1 - Yoshimura, Chihiro A1 - Yule, Catherine M. A1 - Zhang, Yixin X. A1 - Zwart, Jacob A. T1 - Global patterns and drivers of ecosystem functioning in rivers and riparian zones JF - Science Advances N2 - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale. Y1 - 2019 U6 - https://doi.org/10.1126/sciadv.aav0486 SN - 2375-2548 VL - 5 IS - 1 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - GEN A1 - Gorski, Mathias A1 - Jung, Bettina A1 - Li, Yong A1 - Matias-Garcia, Pamela R. A1 - Wuttke, Matthias A1 - Coassin, Stefan A1 - Thio, Chris H. L. A1 - Kleber, Marcus E. A1 - Winkler, Thomas W. A1 - Wanner, Veronika A1 - Chai, Jin-Fang A1 - Chu, Audrey Y. A1 - Cocca, Massimiliano A1 - Feitosa, Mary F. A1 - Ghasemi, Sahar A1 - Hoppmann, Anselm A1 - Horn, Katrin A1 - Li, Man A1 - Nutile, Teresa A1 - Scholz, Markus A1 - Sieber, Karsten B. A1 - Teumer, Alexander A1 - Tin, Adrienne A1 - Wang, Judy A1 - Tayo, Bamidele O. A1 - Ahluwalia, Tarunveer S. A1 - Almgren, Peter A1 - Bakker, Stephan J. L. A1 - Banas, Bernhard A1 - Bansal, Nisha A1 - Biggs, Mary L. A1 - Boerwinkle, Eric A1 - Böttinger, Erwin A1 - Brenner, Hermann A1 - Carroll, Robert J. A1 - Chalmers, John A1 - Chee, Miao-Li A1 - Chee, Miao-Ling A1 - Cheng, Ching-Yu A1 - Coresh, Josef A1 - de Borst, Martin H. A1 - Degenhardt, Frauke A1 - Eckardt, Kai-Uwe A1 - Endlich, Karlhans A1 - Franke, Andre A1 - Freitag-Wolf, Sandra A1 - Gampawar, Piyush A1 - Gansevoort, Ron T. A1 - Ghanbari, Mohsen A1 - Gieger, Christian A1 - Hamet, Pavel A1 - Ho, Kevin A1 - Hofer, Edith A1 - Holleczek, Bernd A1 - Foo, Valencia Hui Xian A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Josyula, Navya Shilpa A1 - Kahonen, Mika A1 - Khor, Chiea-Chuen A1 - Koenig, Wolfgang A1 - Kramer, Holly A1 - Kraemer, Bernhard K. A1 - Kuehnel, Brigitte A1 - Lange, Leslie A. A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Loos, Ruth J. F. A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Milaneschi, Yuri A1 - Mishra, Pashupati P. A1 - Mononen, Nina A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - O'Donoghue, Michelle L. A1 - Orho-Melander, Marju A1 - Pendergrass, Sarah A. A1 - Penninx, Brenda W. J. H. A1 - Preuss, Michael H. A1 - Psaty, Bruce M. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Rosenkranz, Alexander R. A1 - Rossing, Peter A1 - Rotter, Jerome A1 - Sabanayagam, Charumathi A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Schoettker, Ben A1 - Schulz, Christina-Alexandra A1 - Sedaghat, Sanaz A1 - Shaffer, Christian M. A1 - Strauch, Konstantin A1 - Szymczak, Silke A1 - Taylor, Kent D. A1 - Tremblay, Johanne A1 - Chaker, Layal A1 - van der Harst, Pim A1 - van der Most, Peter J. A1 - Verweij, Niek A1 - Voelker, Uwe A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Waterworth, Dawn M. A1 - White, Harvey D. A1 - Wilson, James G. A1 - Wong, Tien-Yin A1 - Woodward, Mark A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Yan A1 - Snieder, Harold A1 - Wanner, Christoph A1 - Boger, Carsten A. A1 - Kottgen, Anna A1 - Kronenberg, Florian A1 - Pattaro, Cristian A1 - Heid, Iris M. T1 - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline T2 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät N2 - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function. T3 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 KW - acute kidney injury KW - end-stage kidney disease KW - genome-wide association KW - study KW - rapid eGFRcrea decline Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379 IS - 19 ER - TY - JOUR A1 - Gorski, Mathias A1 - Jung, Bettina A1 - Li, Yong A1 - Matias-Garcia, Pamela R. A1 - Wuttke, Matthias A1 - Coassin, Stefan A1 - Thio, Chris H. L. A1 - Kleber, Marcus E. A1 - Winkler, Thomas W. A1 - Wanner, Veronika A1 - Chai, Jin-Fang A1 - Chu, Audrey Y. A1 - Cocca, Massimiliano A1 - Feitosa, Mary F. A1 - Ghasemi, Sahar A1 - Hoppmann, Anselm A1 - Horn, Katrin A1 - Li, Man A1 - Nutile, Teresa A1 - Scholz, Markus A1 - Sieber, Karsten B. A1 - Teumer, Alexander A1 - Tin, Adrienne A1 - Wang, Judy A1 - Tayo, Bamidele O. A1 - Ahluwalia, Tarunveer S. A1 - Almgren, Peter A1 - Bakker, Stephan J. L. A1 - Banas, Bernhard A1 - Bansal, Nisha A1 - Biggs, Mary L. A1 - Boerwinkle, Eric A1 - Böttinger, Erwin A1 - Brenner, Hermann A1 - Carroll, Robert J. A1 - Chalmers, John A1 - Chee, Miao-Li A1 - Chee, Miao-Ling A1 - Cheng, Ching-Yu A1 - Coresh, Josef A1 - de Borst, Martin H. A1 - Degenhardt, Frauke A1 - Eckardt, Kai-Uwe A1 - Endlich, Karlhans A1 - Franke, Andre A1 - Freitag-Wolf, Sandra A1 - Gampawar, Piyush A1 - Gansevoort, Ron T. A1 - Ghanbari, Mohsen A1 - Gieger, Christian A1 - Hamet, Pavel A1 - Ho, Kevin A1 - Hofer, Edith A1 - Holleczek, Bernd A1 - Foo, Valencia Hui Xian A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Josyula, Navya Shilpa A1 - Kahonen, Mika A1 - Khor, Chiea-Chuen A1 - Koenig, Wolfgang A1 - Kramer, Holly A1 - Kraemer, Bernhard K. A1 - Kuehnel, Brigitte A1 - Lange, Leslie A. A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Loos, Ruth J. F. A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Milaneschi, Yuri A1 - Mishra, Pashupati P. A1 - Mononen, Nina A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - O'Donoghue, Michelle L. A1 - Orho-Melander, Marju A1 - Pendergrass, Sarah A. A1 - Penninx, Brenda W. J. H. A1 - Preuss, Michael H. A1 - Psaty, Bruce M. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Rosenkranz, Alexander R. A1 - Rossing, Peter A1 - Rotter, Jerome A1 - Sabanayagam, Charumathi A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Schoettker, Ben A1 - Schulz, Christina-Alexandra A1 - Sedaghat, Sanaz A1 - Shaffer, Christian M. A1 - Strauch, Konstantin A1 - Szymczak, Silke A1 - Taylor, Kent D. A1 - Tremblay, Johanne A1 - Chaker, Layal A1 - van der Harst, Pim A1 - van der Most, Peter J. A1 - Verweij, Niek A1 - Voelker, Uwe A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Waterworth, Dawn M. A1 - White, Harvey D. A1 - Wilson, James G. A1 - Wong, Tien-Yin A1 - Woodward, Mark A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Yan A1 - Snieder, Harold A1 - Wanner, Christoph A1 - Boger, Carsten A. A1 - Kottgen, Anna A1 - Kronenberg, Florian A1 - Pattaro, Cristian A1 - Heid, Iris M. T1 - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline JF - Kidney international : official journal of the International Society of Nephrology N2 - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function. KW - acute kidney injury KW - end-stage kidney disease KW - genome-wide association KW - study KW - rapid eGFRcrea decline Y1 - 2020 U6 - https://doi.org/10.1016/j.kint.2020.09.030 SN - 0085-2538 SN - 1523-1755 VL - 99 IS - 4 SP - 926 EP - 939 PB - Elsevier CY - New York ER - TY - JOUR A1 - Ikram, M. Arfan A1 - Fornage, Myriam A1 - Smith, Albert V. A1 - Seshadri, Sudha A1 - Schmidt, Reinhold A1 - Debette, Stephanie A1 - Vrooman, Henri A. A1 - Sigurdsson, Sigurdur A1 - Ropele, Stefan A1 - Taal, H. Rob A1 - Mook-Kanamori, Dennis O. A1 - Coker, Laura H. A1 - Longstreth, W. T. A1 - Niessen, Wiro J. A1 - DeStefano, Anita L. A1 - Beiser, Alexa A1 - Zijdenbos, Alex P. A1 - Struchalin, Maksim A1 - Jack, Clifford R. A1 - Rivadeneira, Fernando A1 - Uitterlinden, Andre G. A1 - Knopman, David S. A1 - Hartikainen, Anna-Liisa A1 - Pennell, Craig E. A1 - Thiering, Elisabeth A1 - Steegers, Eric A. P. A1 - Hakonarson, Hakon A1 - Heinrich, Joachim A1 - Palmer, Lyle J. A1 - Jarvelin, Marjo-Riitta A1 - McCarthy, Mark I. A1 - Grant, Struan F. A. A1 - St Pourcain, Beate A1 - Timpson, Nicholas J. A1 - Smith, George Davey A1 - Sovio, Ulla A1 - Nalls, Mike A. A1 - Au, Rhoda A1 - Hofman, Albert A1 - Gudnason, Haukur A1 - van der Lugt, Aad A1 - Harris, Tamara B. A1 - Meeks, William M. A1 - Vernooij, Meike W. A1 - van Buchem, Mark A. A1 - Catellier, Diane A1 - Jaddoe, Vincent W. V. A1 - Gudnason, Vilmundur A1 - Windham, B. Gwen A1 - Wolf, Philip A. A1 - van Duijn, Cornelia M. A1 - Mosley, Thomas H. A1 - Schmidt, Helena A1 - Launer, Lenore J. A1 - Breteler, Monique M. B. A1 - DeCarli, Charles A1 - Adair, Linda S. A1 - Ang, Wei A1 - Atalay, Mustafa A1 - vanBeijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Coin, Lachlan A1 - Davis, Oliver S. P. A1 - Elliott, Paul A1 - Flexeder, Claudia A1 - Frayling, Tim A1 - Gaillard, Romy A1 - Groen-Blokhuis, Maria A1 - Goh, Liang-Kee A1 - Haworth, Claire M. A. A1 - Hadley, Dexter A1 - Hebebrand, Johannes A1 - Hinney, Anke A1 - Hirschhorn, Joel N. A1 - Holloway, John W. A1 - Holst, Claus A1 - Hottenga, Jouke Jan A1 - Horikoshi, Momoko A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Kilpelainen, Tuomas O. A1 - Kirin, Mirna A1 - Kowgier, Matthew A1 - Lakka, Hanna-Maaria A1 - Lange, Leslie A. A1 - Lawlor, Debbie A. A1 - Lehtimaki, Terho A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Lindi, Virpi A1 - Maggi, Reedik A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Murray, Jeffrey C. A1 - Nivard, Michel A1 - Nohr, Ellen Aagaard A1 - Ntalla, Ioanna A1 - Oken, Emily A1 - Panoutsopoulou, Kalliope A1 - Pararajasingham, Jennifer A1 - Rodriguez, Alina A1 - Salem, Rany M. A1 - Sebert, Sylvain A1 - Siitonen, Niina A1 - Strachan, David P. A1 - Teo, Yik-Ying A1 - Valcarcel, Beatriz A1 - Willemsen, Gonneke A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Cooper, Cyrus A1 - Gillman, Matthew A1 - Hocher, Berthold A1 - Lakka, Timo A. A1 - Mohlke, Karen L. A1 - Dedoussis, George V. A1 - Ong, Ken K. A1 - Pearson, Ewan R. A1 - Price, Thomas S. A1 - Power, Chris A1 - Raitakari, Olli T. A1 - Saw, Seang-Mei A1 - Scherag, Andre A1 - Simell, Olli A1 - Sorensen, Thorkild I. A. A1 - Wilson, James F. T1 - Common variants at 6q22 and 17q21 are associated with intracranial volume JF - Nature genetics N2 - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size. Y1 - 2012 U6 - https://doi.org/10.1038/ng.2245 SN - 1061-4036 VL - 44 IS - 5 SP - 539 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Tucker, Marlee A. A1 - Boehning-Gaese, Katrin A1 - Fagan, William F. A1 - Fryxell, John M. A1 - Van Moorter, Bram A1 - Alberts, Susan C. A1 - Ali, Abdullahi H. A1 - Allen, Andrew M. A1 - Attias, Nina A1 - Avgar, Tal A1 - Bartlam-Brooks, Hattie A1 - Bayarbaatar, Buuveibaatar A1 - Belant, Jerrold L. A1 - Bertassoni, Alessandra A1 - Beyer, Dean A1 - Bidner, Laura A1 - van Beest, Floris M. A1 - Blake, Stephen A1 - Blaum, Niels A1 - Bracis, Chloe A1 - Brown, Danielle A1 - de Bruyn, P. J. Nico A1 - Cagnacci, Francesca A1 - Calabrese, Justin M. A1 - Camilo-Alves, Constanca A1 - Chamaille-Jammes, Simon A1 - Chiaradia, Andre A1 - Davidson, Sarah C. A1 - Dennis, Todd A1 - DeStefano, Stephen A1 - Diefenbach, Duane A1 - Douglas-Hamilton, Iain A1 - Fennessy, Julian A1 - Fichtel, Claudia A1 - Fiedler, Wolfgang A1 - Fischer, Christina A1 - Fischhoff, Ilya A1 - Fleming, Christen H. A1 - Ford, Adam T. A1 - Fritz, Susanne A. A1 - Gehr, Benedikt A1 - Goheen, Jacob R. A1 - Gurarie, Eliezer A1 - Hebblewhite, Mark A1 - Heurich, Marco A1 - Hewison, A. J. Mark A1 - Hof, Christian A1 - Hurme, Edward A1 - Isbell, Lynne A. A1 - Janssen, Rene A1 - Jeltsch, Florian A1 - Kaczensky, Petra A1 - Kane, Adam A1 - Kappeler, Peter M. A1 - Kauffman, Matthew A1 - Kays, Roland A1 - Kimuyu, Duncan A1 - Koch, Flavia A1 - Kranstauber, Bart A1 - LaPoint, Scott A1 - Leimgruber, Peter A1 - Linnell, John D. C. A1 - Lopez-Lopez, Pascual A1 - Markham, A. Catherine A1 - Mattisson, Jenny A1 - Medici, Emilia Patricia A1 - Mellone, Ugo A1 - Merrill, Evelyn A1 - Mourao, Guilherme de Miranda A1 - Morato, Ronaldo G. A1 - Morellet, Nicolas A1 - Morrison, Thomas A. A1 - Diaz-Munoz, Samuel L. A1 - Mysterud, Atle A1 - Nandintsetseg, Dejid A1 - Nathan, Ran A1 - Niamir, Aidin A1 - Odden, John A1 - Oliveira-Santos, Luiz Gustavo R. A1 - Olson, Kirk A. A1 - Patterson, Bruce D. A1 - de Paula, Rogerio Cunha A1 - Pedrotti, Luca A1 - Reineking, Bjorn A1 - Rimmler, Martin A1 - Rogers, Tracey L. A1 - Rolandsen, Christer Moe A1 - Rosenberry, Christopher S. A1 - Rubenstein, Daniel I. A1 - Safi, Kamran A1 - Said, Sonia A1 - Sapir, Nir A1 - Sawyer, Hall A1 - Schmidt, Niels Martin A1 - Selva, Nuria A1 - Sergiel, Agnieszka A1 - Shiilegdamba, Enkhtuvshin A1 - Silva, Joao Paulo A1 - Singh, Navinder A1 - Solberg, Erling J. A1 - Spiegel, Orr A1 - Strand, Olav A1 - Sundaresan, Siva A1 - Ullmann, Wiebke A1 - Voigt, Ulrich A1 - Wall, Jake A1 - Wattles, David A1 - Wikelski, Martin A1 - Wilmers, Christopher C. A1 - Wilson, John W. A1 - Wittemyer, George A1 - Zieba, Filip A1 - Zwijacz-Kozica, Tomasz A1 - Mueller, Thomas T1 - Moving in the Anthropocene BT - global reductions in terrestrial mammalian movements JF - Science N2 - Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission. Y1 - 2018 U6 - https://doi.org/10.1126/science.aam9712 SN - 0036-8075 SN - 1095-9203 VL - 359 IS - 6374 SP - 466 EP - 469 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Read, Betsy A. A1 - Kegel, Jessica A1 - Klute, Mary J. A1 - Kuo, Alan A1 - Lefebvre, Stephane C. A1 - Maumus, Florian A1 - Mayer, Christoph A1 - Miller, John A1 - Monier, Adam A1 - Salamov, Asaf A1 - Young, Jeremy A1 - Aguilar, Maria A1 - Claverie, Jean-Michel A1 - Frickenhaus, Stephan A1 - Gonzalez, Karina A1 - Herman, Emily K. A1 - Lin, Yao-Cheng A1 - Napier, Johnathan A1 - Ogata, Hiroyuki A1 - Sarno, Analissa F. A1 - Shmutz, Jeremy A1 - Schroeder, Declan A1 - de Vargas, Colomban A1 - Verret, Frederic A1 - von Dassow, Peter A1 - Valentin, Klaus A1 - Van de Peer, Yves A1 - Wheeler, Glen A1 - Dacks, Joel B. A1 - Delwiche, Charles F. A1 - Dyhrman, Sonya T. A1 - Glöckner, Gernot A1 - John, Uwe A1 - Richards, Thomas A1 - Worden, Alexandra Z. A1 - Zhang, Xiaoyu A1 - Grigoriev, Igor V. A1 - Allen, Andrew E. A1 - Bidle, Kay A1 - Borodovsky, M. A1 - Bowler, C. A1 - Brownlee, Colin A1 - Cock, J. Mark A1 - Elias, Marek A1 - Gladyshev, Vadim N. A1 - Groth, Marco A1 - Guda, Chittibabu A1 - Hadaegh, Ahmad A1 - Iglesias-Rodriguez, Maria Debora A1 - Jenkins, J. A1 - Jones, Bethan M. A1 - Lawson, Tracy A1 - Leese, Florian A1 - Lindquist, Erika A1 - Lobanov, Alexei A1 - Lomsadze, Alexandre A1 - Malik, Shehre-Banoo A1 - Marsh, Mary E. A1 - Mackinder, Luke A1 - Mock, Thomas A1 - Müller-Röber, Bernd A1 - Pagarete, Antonio A1 - Parker, Micaela A1 - Probert, Ian A1 - Quesneville, Hadi A1 - Raines, Christine A1 - Rensing, Stefan A. A1 - Riano-Pachon, Diego Mauricio A1 - Richier, Sophie A1 - Rokitta, Sebastian A1 - Shiraiwa, Yoshihiro A1 - Soanes, Darren M. A1 - van der Giezen, Mark A1 - Wahlund, Thomas M. A1 - Williams, Bryony A1 - Wilson, Willie A1 - Wolfe, Gordon A1 - Wurch, Louie L. T1 - Pan genome of the phytoplankton Emiliania underpins its global distribution JF - Nature : the international weekly journal of science N2 - Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions. Y1 - 2013 U6 - https://doi.org/10.1038/nature12221 SN - 0028-0836 SN - 1476-4687 VL - 499 IS - 7457 SP - 209 EP - 213 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Cohen, Andrew A1 - Campisano, C. A1 - Arrowsmith, J. Ramón A1 - Asrat, Asfawossen A1 - Behrensmeyer, A. K. A1 - Deino, A. A1 - Feibel, C. A1 - Hill, A. A1 - Johnson, R. A1 - Kingston, J. A1 - Lamb, Henry F. A1 - Lowenstein, T. A1 - Noren, A. A1 - Olago, D. A1 - Owen, R. B. A1 - Potts, R. A1 - Reed, Kate A1 - Renaut, R. A1 - Schäbitz, Frank A1 - Tiercelin, J. -J. A1 - Trauth, Martin H. A1 - Wynn, J. A1 - Ivory, S. A1 - Brady, K. A1 - Rodysill, J. A1 - Githiri, J. A1 - Russell, J. A1 - Förster, Verena A1 - Dommain, René A1 - Rucina, S. A1 - Deocampo, D. A1 - Russell, J. A1 - Billingsley, A. A1 - Beck, C. A1 - Dorenbeck, G. A1 - Dullo, L. A1 - Feary, D. A1 - Garello, D. A1 - Gromig, R. A1 - Johnson, T. A1 - Junginger, A. A1 - Karanja, M. A1 - Kimburi, E. A1 - Mbuthia, A. A1 - McCartney, T. A1 - McNulty, E. A1 - Muiruri, V. A1 - Nambiro, E. A1 - Negash, E. W. A1 - Njagi, D. A1 - Wilson, J. N. A1 - Rabideaux, N. A1 - Raub, T. A1 - Sier, M. J. A1 - Smith, P. A1 - Urban, J. A1 - Warren, M. A1 - Yadeta, M. A1 - Yost, C. A1 - Zinaye, B. T1 - The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits JF - Scientific Drilling N2 - The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012-2014 HSPDP coring campaign. Y1 - 2016 U6 - https://doi.org/10.5194/sd-21-1-2016 SN - 1816-8957 SN - 1816-3459 VL - 21 SP - 1 EP - 16 PB - Copernicus CY - Göttingen ER - TY - GEN A1 - Cohen, Abby A1 - Campisano, Christopher A1 - Arrowsmith, J. Ramon A1 - Asrat, Asfawossen A1 - Behrensmeyer, A. K. A1 - Deino, A. A1 - Feibel, C. A1 - Hill, A. A1 - Johnson, R. A1 - Kingston, J. A1 - Lamb, Henry F. A1 - Lowenstein, T. A1 - Noren, A. A1 - Olago, D. A1 - Owen, Richard Bernhart A1 - Potts, R. A1 - Reed, Kate A1 - Renaut, R. A1 - Schäbitz, Frank A1 - Tiercelin, J.-J. A1 - Trauth, Martin H. A1 - Wynn, J. A1 - Ivory, S. A1 - Brady, K. A1 - O’Grady, R. A1 - Rodysill, J. A1 - Githiri, J. A1 - Russell, Joellen A1 - Foerster, Verena A1 - Dommain, René A1 - Rucina, J. S. A1 - Deocampo, D. A1 - Russell, J. A1 - Billingsley, A. A1 - Beck, C. A1 - Dorenbeck, G. A1 - Dullo, L. A1 - Feary, D. A1 - Garello, D. A1 - Gromig, R. A1 - Johnson, T. A1 - Junginger, Annett A1 - Karanja, M. A1 - Kimburi, E. A1 - Mbuthia, A. A1 - McCartney, Tannis A1 - McNulty, E. A1 - Muiruri, V. A1 - Nambiro, E. A1 - Negash, E. W. A1 - Njagi, D. A1 - Wilson, J. N. A1 - Rabideaux, N. A1 - Raub, Timothy A1 - Sier, Mark Jan A1 - Smith, P. A1 - Urban, J. A1 - Warren, M. A1 - Yadeta, M. A1 - Yost, Chad A1 - Zinaye, B. T1 - The Hominin Sites and Paleolakes Drilling Project BT - inferring the environmental context of human evolution from eastern African rift lake deposits T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012-2014 HSPDP coring campaign. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 611 KW - Turkana-Basin KW - Adar formation KW - climate-change KW - olorgesailie formation KW - Southern Ethiopia KW - global climate KW - Kenya Rift KW - Pleistocene KW - variability KW - patterns Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412498 IS - 611 ER - TY - JOUR A1 - Maslin, Mark A. A1 - Brierley, Chris M. A1 - Milner, Alice M. A1 - Shultz, Susanne A1 - Trauth, Martin H. A1 - Wilson, Katy E. T1 - East African climate pulses and early human evolution JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Current evidence suggests that all of the major events in hominin evolution have occurred in East Africa. Over the last two decades, there has been intensive work undertaken to understand African palaeoclimate and tectonics in order to put together a coherent picture of how the environment of East Africa has varied in the past. The landscape of East Africa has altered dramatically over the last 10 million years. It has changed from a relatively flat, homogenous region covered with mixed tropical forest, to a varied and heterogeneous environment, with mountains over 4 km high and vegetation ranging from desert to cloud forest. The progressive rifting of East Africa has also generated numerous lake basins, which are highly sensitive to changes in the local precipitation-evaporation regime. There is now evidence that the presence of precession-driven, ephemeral deep-water lakes in East Africa were concurrent with major events in hominin evolution. It seems the unusual geology and climate of East Africa created periods of highly variable local climate, which, it has been suggested could have driven hominin speciation, encephalisation and dispersal out of Africa. One example is the significant hominin speciation and brain expansion event at -1.8 Ma that seems to have been coeval with the occurrence of highly variable, extensive, deep-water lakes. This complex, climatically very variable setting inspired first the variability selection hypothesis, which was then the basis for the pulsed climate variability hypothesis. The newer of the two suggests that the long-term drying trend in East Africa was punctuated by episodes of short, alternating periods of extreme humidity and aridity. Both hypotheses, together with other key theories of climate-evolution linkages, are discussed in this paper. Though useful the actual evolution mechanisms, which led to early hominins are still unclear and continue to be debated. However, it is clear that an understanding of East African lakes and their palaeoclimate history is required to understand the context within which humans evolved and eventually left East Africa. (C) 2014 The Authors. Published by Elsevier Ltd. KW - Human evolution KW - East Africa KW - Palaeoclimatology KW - Palaeoliminology KW - Tectonics KW - Hominin KW - Orbital forcing KW - Cenozoic climate transitions KW - Pulsed climate variability hypothesis Y1 - 2014 U6 - https://doi.org/10.1016/j.quascirev.2014.06.012 SN - 0277-3791 VL - 101 SP - 1 EP - 17 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kunnus, Kristjan A1 - Josefsson, I. A1 - Rajkovic, Ivan A1 - Schreck, Simon A1 - Quevedo, Wilson A1 - Beye, Martin A1 - Weniger, C. A1 - Gruebel, S. A1 - Scholz, M. A1 - Nordlund, D. A1 - Zhang, W. A1 - Hartsock, R. W. A1 - Gaffney, K. J. A1 - Schlotter, W. F. A1 - Turner, J. J. A1 - Kennedy, B. A1 - Hennies, F. A1 - de Groot, F. M. F. A1 - Techert, S. A1 - Odelius, Michael A1 - Wernet, Ph. A1 - Föhlisch, Alexander T1 - Identification of the dominant photochemical pathways and mechanistic insights to the ultrafast ligand exchange of Fe(CO)(5) to Fe(CO)(4)EtOH JF - Structural dynamics N2 - We utilized femtosecond time-resolved resonant inelastic X-ray scattering and ab initio theory to study the transient electronic structure and the photoinduced molecular dynamics of a model metal carbonyl photocatalyst Fe(CO)(5) in ethanol solution. We propose mechanistic explanation for the parallel ultrafast intra-molecular spin crossover and ligation of the Fe(CO)(4) which are observed following a charge transfer photoexcitation of Fe(CO)(5) as reported in our previous study [ Wernet et al., Nature 520, 78 (2015)]. We find that branching of the reaction pathway likely happens in the (1)A(1) state of Fe(CO)(4). A sub-picosecond time constant of the spin crossover from B-1(2) to B-3(2) is rationalized by the proposed B-1(2) -> (1)A(1) -> B-3(2) mechanism. Ultrafast ligation of the B-1(2) Fe(CO)(4) state is significantly faster than the spin-forbidden and diffusion limited ligation process occurring from the B-3(2) Fe(CO)(4) ground state that has been observed in the previous studies. We propose that the ultrafast ligation occurs via B-1(2) -> (1)A(1) -> (1)A'Fe(CO)(4)EtOH pathway and the time scale of the (1)A(1) Fe(CO)(4) state ligation is governed by the solute-solvent collision frequency. Our study emphasizes the importance of understanding the interaction of molecular excited states with the surrounding environment to explain the relaxation pathways of photoexcited metal carbonyls in solution. (C) 2016 Author(s). Y1 - 2016 U6 - https://doi.org/10.1063/1.4941602 SN - 2329-7778 VL - 3 PB - American Institute of Physics CY - Washington ER - TY - JOUR A1 - McCool, Weston C. A1 - Codding, Brian F. A1 - Vernon, Kenneth B. A1 - Wilson, Kurt M. A1 - Yaworsky, Peter M. A1 - Marwan, Norbert A1 - Kennett, Douglas J. T1 - Climate change-induced population pressure drives high rates of lethal violence in the Prehispanic central Andes JF - Proceedings of the National Academy of Sciences of the United States of America : PNAS N2 - Understanding the influence of climate change and population pressure on human conflict remains a critically important topic in the social sciences. Long-term records that evaluate these dynamics across multiple centuries and outside the range of modern climatic variation are especially capable of elucidating the relative effect of-and the interaction between-climate and demography. This is crucial given that climate change may structure population growth and carrying capacity, while both climate and population influence per capita resource availability. This study couples paleoclimatic and demographic data with osteological evaluations of lethal trauma from 149 directly accelerator mass spectrometry C-14-dated individuals from the Nasca highland region of Peru. Multiple local and supraregional precipitation proxies are combined with a summed probability distribution of 149 C-14 dates to estimate population dynamics during a 700-y study window. Counter to previous findings, our analysis reveals a precipitous increase in violent deaths associated with a period of productive and stable climate, but volatile population dynamics. We conclude that favorable local climate conditions fostered population growth that put pressure on the marginal and highly circumscribed resource base, resulting in violent resource competition that manifested in over 450 y of internecine warfare. These findings help support a general theory of intergroup violence, indicating that relative resource scarcity-whether driven by reduced resource abundance or increased competition-can lead to violence in subsistence societies when the outcome is lower per capita resource availability. KW - climate change KW - population pressure KW - warfare KW - lethal violence KW - Andes Y1 - 2022 U6 - https://doi.org/10.1073/pnas.2117556119 SN - 0027-8424 SN - 1091-6490 VL - 119 IS - 17 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Cook, Katherine V. A1 - Li, Chuang A1 - Cai, Haiyuan A1 - Krumholz, Lee R. A1 - Hambright, K. David A1 - Paerl, Hans W. A1 - Steffen, Morgan M. A1 - Wilson, Alan E. A1 - Burford, Michele A. A1 - Grossart, Hans-Peter A1 - Hamilton, David P. A1 - Jiang, Helong A1 - Sukenik, Assaf A1 - Latour, Delphine A1 - Meyer, Elisabeth I. A1 - Padisak, Judit A1 - Qin, Boqiang A1 - Zamor, Richard M. A1 - Zhu, Guangwei T1 - The global Microcystis interactome JF - Limnology and oceanography N2 - Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs). CyanoHAB species are known to shape bacterial community composition and to rely on functions provided by the associated bacteria, leading to the hypothesized cyanoHAB interactome, a coevolved community of synergistic and interacting bacteria species, each necessary for the success of the others. Here, we surveyed the microbiome associated with Microcystis aeruginosa during blooms in 12 lakes spanning four continents as an initial test of the hypothesized Microcystis interactome. We predicted that microbiome composition and functional potential would be similar across blooms globally. Our results, as revealed by 16S rRNA sequence similarity, indicate that M. aeruginosa is cosmopolitan in lakes across a 280 degrees longitudinal and 90 degrees latitudinal gradient. The microbiome communities were represented by a wide range of operational taxonomic units and relative abundances. Highly abundant taxa were more related and shared across most sites and did not vary with geographic distance, thus, like Microcystis, revealing no evidence for dispersal limitation. High phylogenetic relatedness, both within and across lakes, indicates that microbiome bacteria with similar functional potential were associated with all blooms. While Microcystis and the microbiome bacteria shared many genes, whole-community metagenomic analysis revealed a suite of biochemical pathways that could be considered complementary. Our results demonstrate a high degree of similarity across global Microcystis blooms, thereby providing initial support for the hypothesized Microcystis interactome. Y1 - 2019 U6 - https://doi.org/10.1002/lno.11361 SN - 0024-3590 SN - 1939-5590 VL - 65 SP - S194 EP - S207 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Muster, Sina A1 - Riley, William J. A1 - Roth, Kurt A1 - Langer, Moritz A1 - Aleina, Fabio Cresto A1 - Koven, Charles D. A1 - Lange, Stephan A1 - Bartsch, Annett A1 - Grosse, Guido A1 - Wilson, Cathy J. A1 - Jones, Benjamin M. A1 - Boike, Julia T1 - Size distributions of arctic waterbodies reveal consistent relations in their statistical moments in space and time JF - Frontiers in Earth Science N2 - Arctic lowlands are characterized by large numbers of small waterbodies, which are known to affect surface energy budgets and the global carbon cycle. Statistical analysis of their size distributions has been hindered by the shortage of observations at sufficiently high spatial resolutions. This situation has now changed with the high-resolution (<5 m) circum-Arctic Permafrost Region Pond and Lake (PeRL) database recently becoming available. We have used this database to make the first consistent, high-resolution estimation of Arctic waterbody size distributions, with surface areas ranging from 0.0001 km(2) (100 m(2)) to 1 km(2). We found that the size distributions varied greatly across the thirty study regions investigated and that there was no single universal size distribution function (including power-law distribution functions) appropriate across all of the study regions. We did, however, find close relationships between the statistical moments (mean, variance, and skewness) of the waterbody size distributions from different study regions. Specifically, we found that the spatial variance increased linearly with mean waterbody size (R-2 = 0.97, p < 2.2e-16) and that the skewness decreased approximately hyperbolically. We have demonstrated that these relationships (1) hold across the 30 Arctic study regions covering a variety of (bio)climatic and permafrost zones, (2) hold over time in two of these study regions for which multi-decadal satellite imagery is available, and (3) can be reproduced by simulating rising water levels in a high-resolution digital elevation model. The consistent spatial and temporal relationships between the statistical moments of the waterbody size distributions underscore the dominance of topographic controls in lowland permafrost areas. These results provide motivation for further analyses of the factors involved in waterbody development and spatial distribution and for investigations into the possibility of using statistical moments to predict future hydrologic dynamics in the Arctic. KW - permafrost KW - hydrology KW - waterbodies KW - size distribution KW - thermokarst KW - statistical moments KW - ponds KW - lakes Y1 - 2019 U6 - https://doi.org/10.3389/feart.2019.00005 SN - 2296-6463 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - BOOK A1 - Wilson, M. A1 - Neumann, Else Ragnhild A1 - Davies, G. R. A1 - Timmerman, Martin Jan A1 - Heeremans, Michel A1 - Larsen, Bjoern Tore T1 - Permo-carboniferous magmatism and rifting in Europe T3 - Geological Society special publication Y1 - 2004 UR - http://www.geolsoc.org.uk/template.cfm?name=bookshop_details&action=details&id=302 SN - 1-86239-152-1 VL - 223 PB - Geological Society CY - London ER - TY - JOUR A1 - Kunnus, Kristjan A1 - Josefsson, Ida A1 - Schreck, Simon A1 - Quevedo, Wilson A1 - Miedema, Piter S. A1 - Techert, Simone A1 - de Groot, Frank M. F. A1 - Odelius, Michael A1 - Wernet, Philippe A1 - Föhlisch, Alexander T1 - From Ligand Fields to Molecular Orbitals: Probing the Local Valence Electronic Structure of Ni2+ in Aqueous Solution with Resonant Inelastic X-ray Scattering JF - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry N2 - Bonding of the Ni2+(aq) complex is investigated with an unprecedented combination of resonant inelastic X-ray scattering (RIXS) measurements and ab initio calculations at the Ni L absorption edge. The spectra directly reflect the relative energies of the ligand-field and charge-transfer valence-excited states. They give element-specific access with atomic resolution to the ground-state electronic structure of the complex and allow quantification of ligand-field strength and 3d-3d electron correlation interactions in the Ni2+(aq) complex. The experimentally determined ligand-field strength is 10Dq = 1.1 eV. This and the Racah parameters characterizing 3d-3d Coulomb interactions B = 0.13 eV and C = 0.42 eV as readily derived from the measured energies match very well with the results from UV-vis spectroscopy. Our results demonstrate how L-edge RIXS can be used to complement existing spectroscopic tools for the investigation of bonding in 3d transition-metal coordination compounds in solution. The ab initio RASPT2 calculation is successfully used to simulate the L-edge RIXS spectra. Y1 - 2013 U6 - https://doi.org/10.1021/jp4100813 SN - 1520-6106 VL - 117 IS - 51 SP - 16512 EP - 16521 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Wernet, Philippe A1 - Kunnus, Kristjan A1 - Josefsson, Ida A1 - Rajkovic, Ivan A1 - Quevedo, Wilson A1 - Beye, Martin A1 - Schreck, Simon A1 - Gruebel, S. A1 - Scholz, Mirko A1 - Nordlund, Dennis A1 - Zhang, Wenkai A1 - Hartsock, Robert W. A1 - Schlotter, William F. A1 - Turner, Joshua J. A1 - Kennedy, Brian A1 - Hennies, Franz A1 - de Groot, Frank M. F. A1 - Gaffney, Kelly J. A1 - Techert, Simone A1 - Odelius, Michael A1 - Föhlisch, Alexander T1 - Orbital-specific mapping of the ligand exchange dynamics of Fe(CO)(5) in solution JF - Nature : the international weekly journal of science N2 - Transition-metal complexes have long attracted interest for fundamental chemical reactivity studies and possible use in solar energy conversion(1,2). Electronic excitation, ligand loss from the metal centre, or a combination of both, creates changes in charge and spin density at the metal site(3-11) that need to be controlled to optimize complexes for photocatalytic hydrogen production(8) and selective carbon-hydrogen bond activation(9-11). An understanding at the molecular level of how transition-metal complexes catalyse reactions, and in particular of the role of the short-lived and reactive intermediate states involved, will be critical for such optimization. However, suitable methods for detailed characterization of electronic excited states have been lacking. Here we show, with the use of X-ray laser-based femtosecond-resolution spectroscopy and advanced quantum chemical theory to probe the reaction dynamics of the benchmark transition-metal complex Fe(CO)(5) in solution, that the photo-induced removal of CO generates the 16-electron Fe(CO)(4) species, a homogeneous catalyst(12,13) with an electron deficiency at the Fe centre(14,15), in a hitherto unreported excited singlet state that either converts to the triplet ground state or combines with a CO or solvent molecule to regenerate a penta-coordinated Fe species on a sub-picosecond timescale. This finding, which resolves the debate about the relative importance of different spin channels in the photochemistry of Fe(CO)(5) (refs 4, 16-20), was made possible by the ability of femtosecond X-ray spectroscopy to probe frontier-orbital interactions with atom specificity. We expect the method to be broadly applicable in the chemical sciences, and to complement approaches that probe structural dynamics in ultrafast processes. Y1 - 2015 U6 - https://doi.org/10.1038/nature14296 SN - 0028-0836 SN - 1476-4687 VL - 520 IS - 7545 SP - 78 EP - 81 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Wernet, Philippe A1 - Kunnus, Kristjan A1 - Schreck, Simon A1 - Quevedo, Wilson A1 - Kurian, Reshmi A1 - Techert, Simone A1 - de Groot, Frank M. F. A1 - Odelius, Michael A1 - Föhlisch, Alexander T1 - Dissecting local atomic and intermolecular interactions of transition-metal ions in solution with selective X-ray spectroscopy JF - The journal of physical chemistry letters N2 - Determining covalent and charge-transfer contributions to bonding in solution has remained an experimental challenge. Here, the quenching of fluorescence decay channels as expressed in dips in the L-edge X-ray spectra of solvated 3d transition-metal ions and complexes was reported as a probe. With a full set of experimental and theoretical ab initio L-edge X-ray spectra of aqueous Cr3+, including resonant inelastic X-ray scattering, we address covalency and charge transfer for this prototypical transition-metal ion in solution. We dissect local atomic effects from intermolecular interactions and quantify X-ray optical effects. We find no evidence for the asserted ultrafast charge transfer to the solvent and show that the dips are readily explained by X-ray optical effects and local atomic state dependence of the fluorescence yield. Instead, we find, besides ionic interactions, a covalent contribution to the bonding in the aqueous complex of ligand-to-metal charge-transfer character. Y1 - 2012 U6 - https://doi.org/10.1021/jz301486u SN - 1948-7185 VL - 3 IS - 23 SP - 3448 EP - 3453 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Wilson, J. S. A1 - Chawdhury, Nazia A1 - Al-Mandhary, Muna R. A. A1 - Younus, M. A1 - Khan, Muhammad S. A1 - Raithby, Paul R. A1 - Friend, Richard H. T1 - The energy gap law for triplet States in Pt-containing conjugated polymers and monomers Y1 - 2001 ER - TY - JOUR A1 - Kubin, Markus A1 - Kern, Jan A1 - Gul, Sheraz A1 - Kroll, Thomas A1 - Chatterjee, Ruchira A1 - Loechel, Heike A1 - Fuller, Franklin D. A1 - Sierra, Raymond G. A1 - Quevedo, Wilson A1 - Weniger, Christian A1 - Rehanek, Jens A1 - Firsov, Anatoly A1 - Laksmono, Hartawan A1 - Weninger, Clemens A1 - Alonso-Mori, Roberto A1 - Nordlund, Dennis L. A1 - Lassalle-Kaiser, Benedikt A1 - Glownia, James M. A1 - Krzywinski, Jacek A1 - Moeller, Stefan A1 - Turner, Joshua J. A1 - Minitti, Michael P. A1 - Dakovski, Georgi L. A1 - Koroidov, Sergey A1 - Kawde, Anurag A1 - Kanady, Jacob S. A1 - Tsui, Emily Y. A1 - Suseno, Sandy A1 - Han, Zhiji A1 - Hill, Ethan A1 - Taguchi, Taketo A1 - Borovik, Andrew S. A1 - Agapie, Theodor A1 - Messinger, Johannes A1 - Erko, Alexei A1 - Föhlisch, Alexander A1 - Bergmann, Uwe A1 - Mitzner, Rolf A1 - Yachandra, Vittal K. A1 - Yano, Junko A1 - Wernet, Philippe T1 - Soft x-ray absorption spectroscopy of metalloproteins and high-valent metal-complexes at room temperature using free-electron lasers JF - Structural dynamics N2 - X-ray absorption spectroscopy at the L-edge of 3d transition metals provides unique information on the local metal charge and spin states by directly probing 3d-derived molecular orbitals through 2p-3d transitions. However, this soft x-ray technique has been rarely used at synchrotron facilities for mechanistic studies of metalloenzymes due to the difficulties of x-ray-induced sample damage and strong background signals from light elements that can dominate the low metal signal. Here, we combine femtosecond soft x-ray pulses from a free-electron laser with a novel x-ray fluorescence-yield spectrometer to overcome these difficulties. We present L-edge absorption spectra of inorganic high-valent Mn complexes (Mn similar to 6-15 mmol/l) with no visible effects of radiation damage. We also present the first L-edge absorption spectra of the oxygen evolving complex (Mn4CaO5) in Photosystem II (Mn < 1 mmol/l) at room temperature, measured under similar conditions. Our approach opens new ways to study metalloenzymes under functional conditions. (C) 2017 Author(s). Y1 - 2017 U6 - https://doi.org/10.1063/1.4986627 SN - 2329-7778 VL - 4 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Mitzner, Rolf A1 - Rehanek, Jens A1 - Kern, Jan A1 - Gul, Sheraz A1 - Hattne, Johan A1 - Taguchi, Taketo A1 - Alonso-Mori, Roberto A1 - Tran, Rosalie A1 - Weniger, Christian A1 - Schröder, Henning A1 - Quevedo, Wilson A1 - Laksmono, Hartawan A1 - Sierra, Raymond G. A1 - Han, Guangye A1 - Lassalle-Kaiser, Benedikt A1 - Koroidov, Sergey A1 - Kubicek, Katharina A1 - Schreck, Simon A1 - Kunnus, Kristjan A1 - Brzhezinskaya, Maria A1 - Firsov, Alexander A1 - Minitti, Michael P. A1 - Turner, Joshua J. A1 - Möller, Stefan A1 - Sauter, Nicholas K. A1 - Bogan, Michael J. A1 - Nordlund, Dennis A1 - Schlotter, William F. A1 - Messinger, Johannes A1 - Borovik, Andrew S. A1 - Techert, Simone A1 - de Groot, Frank M. F. A1 - Föhlisch, Alexander A1 - Erko, Alexei A1 - Bergmann, Uwe A1 - Yachandra, Vittal K. A1 - Wernet, Philippe A1 - Yano, Junko T1 - L-edge x-ray absorption spectroscopy of dilute systems relevant to metalloproteins using an X-ray free-electron laser JF - The journal of physical chemistry letters N2 - L-edge spectroscopy of 3d transition metals provides important electronic structure information and has been used in many fields. However, the use of this method for studying dilute aqueous systems, such as metalloenzymes, has not been prevalent because of severe radiation damage and the lack of suitable detection systems. Here we present spectra from a dilute Mn aqueous solution using a high-transmission zone-plate spectrometer at the Linac Coherent Light Source (LCLS). The spectrometer has been optimized for discriminating the Mn L-edge signal from the overwhelming 0 K-edge background that arises from water and protein itself, and the ultrashort LCLS X-ray pulses can outrun X-ray induced damage. We show that the deviations of the partial-fluorescence yield-detected spectra from the true absorption can be well modeled using the state-dependence of the fluorescence yield, and discuss implications for the application of our concept to biological samples. Y1 - 2013 U6 - https://doi.org/10.1021/jz401837f SN - 1948-7185 VL - 4 IS - 21 SP - 3641 EP - 3647 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Jay, Raphael M. A1 - Norell, Jesper A1 - Eckert, Sebastian A1 - Hantschmann, Markus A1 - Beye, Martin A1 - Kennedy, Brian A1 - Quevedo, Wilson A1 - Schlotter, William F. A1 - Dakovski, Georgi L. A1 - Minitti, Michael P. A1 - Hoffmann, Matthias C. A1 - Mitra, Ankush A1 - Moeller, Stefan P. A1 - Nordlund, Dennis A1 - Zhang, Wenkai A1 - Liang, Huiyang W. A1 - Kunnus, Kristian A1 - Kubicek, Katharina A1 - Techert, Simone A. A1 - Lundberg, Marcus A1 - Wernet, Philippe A1 - Gaffney, Kelly A1 - Odelius, Michael A1 - Föhlisch, Alexander T1 - Disentangling Transient Charge Density and Metal-Ligand Covalency in Photoexcited Ferricyanide with Femtosecond Resonant Inelastic Soft X-ray Scattering JF - The journal of physical chemistry letters N2 - Soft X-ray spectroscopies are ideal probes of the local valence electronic structure of photocatalytically active metal sites. Here, we apply the selectivity of time resolved resonant inelastic X-ray scattering at the iron L-edge to the transient charge distribution of an optically excited charge-transfer state in aqueous ferricyanide. Through comparison to steady-state spectra and quantum chemical calculations, the coupled effects of valence-shell closing and ligand-hole creation are experimentally and theoretically disentangled and described in terms of orbital occupancy, metal-ligand covalency, and ligand field splitting, thereby extending established steady-state concepts to the excited-state domain. pi-Back-donation is found to be mainly determined by the metal site occupation, whereas the ligand hole instead influences sigma-donation. Our results demonstrate how ultrafast resonant inelastic X-ray scattering can help characterize local charge distributions around catalytic metal centers in short-lived charge-transfer excited states, as a step toward future rationalization and tailoring of photocatalytic capabilities of transition-metal complexes. Y1 - 2018 U6 - https://doi.org/10.1021/acs.jpclett.8b01429 SN - 1948-7185 VL - 9 IS - 12 SP - 3538 EP - 3543 PB - American Chemical Society CY - Washington ER -