TY  - JOUR
A1  - Melcher, Ralph
A1  - Hartmann, Elena
A1  - Zopf, Waltraud
A1  - Herterich, Sabine
A1  - Wilke, Philipp
A1  - Mueller, Ludwig
A1  - Rosler, Eduard
A1  - Kudlich, Theodor
A1  - Al-Taie, Oliver
A1  - Rosenwald, Andreas
A1  - Katzenberger, Tiemo
A1  - Scholtka, Bettina
A1  - Seibold, Stefan
A1  - Rogoll, Dorothee
A1  - Scheppach, Wolfgang
A1  - Scheurlen, Michael
A1  - Luehrs, Hardi
T1  - LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability
JF  - Carcinogenesis : a comprehensive survey
N2  - Background and aims. Tumor suppressor genes are often located in frequently deleted chromosomal regions of colorectal cancers (CRCs). In contrast to microsatellite stable (MSS) tumors, only few loss of heterozygosity (LOH) studies were performed in microsatellite instable (MSI) tumors, because MSI carcinomas are generally considered to be chromosomally stable and classical LOH studies are not feasible due to MSI. The single nucleotide polymorphism (SNP) array technique enables LOH studies also in MSI CRC. The aim of our study was to analyse tissue from MSI and MSS CRC for the existence of (frequently) deleted chromosomal regions and tumor suppressor genes located therein. Methods and results. We analyzed tissues from 32 sporadic CRCs and their corresponding normal mucosa (16 MSS and 16 MSI tumors) by means of 50K SNP array analysis. MSS tumors displayed chromosomal instability that resulted in multiple deleted (LOH) and amplified regions and led to the identification of MTUS1 (8p22) as a candidate tumor suppressor gene in this region. Although the MSI tumors were chromosomally stable, we found several copy neutral LOHs (cnLOH) in the MSI tumors; these appear to be instrumental in the inactivation of the tumor suppressor gene hMLH1 and a gene located in chromosomal region 6pter-p22. Discussion. Our results suggest that in addition to classical LOH, cnLOH is an important mutational event in relation to the carcinogenesis of MSS and MSI tumors, causing the inactivation of a tumor suppressor gene without copy number alteration of the respective region; this is crucial for the development of MSI tumors and for some chromosomal regions in MSS tumors.
Y1  - 2011
U6  - https://doi.org/10.1093/carcin/bgr011
SN  - 0143-3334
VL  - 32
IS  - 4
SP  - 636
EP  - 642
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Anklam, Elke
A1  - Behler, Jörg
A1  - Dingermann, Theodor
A1  - Elsinghorst, Paul
A1  - Fischer, Jochen
A1  - Esselen, Melanie
A1  - Foerster, Christian
A1  - Fröhlich, Daniel
A1  - Goedel, Werner Andreas
A1  - Gregory, Peter
A1  - Grimme, Stefan
A1  - Hackenberger, Christian
A1  - Hansmann, Max
A1  - Heppekausen, Johannes
A1  - Hasenstab-Riedel, Sebastian
A1  - Kirchhoff, Erhard
A1  - Kratz, Karl-Ludwig
A1  - Krausz, Ferenc
A1  - Linker, Torsten
A1  - List, Benjamin
A1  - Ray, Kallol
A1  - Salzer, Reiner
A1  - Schubert, Ulrich
A1  - Schueth, Ferdi
A1  - Schwarz, Helmut
A1  - Schwietzke, Uta
A1  - Strey, Reinhard
A1  - Stumpf, Thorsten
A1  - Vaagt, Franziska
A1  - Volodkin, Dmitry
A1  - Wilke, Guenther
A1  - Zass, Engelbert
A1  - Zemb, Thomas
T1  - Awards
JF  - Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker
Y1  - 2013
U6  - https://doi.org/10.1002/nadc.201390372
SN  - 1439-9598
SN  - 1868-0054
VL  - 61
IS  - 11
SP  - 1145
EP  - 1148
PB  - Ges. Dt. Chemiker
CY  - Frankfurt, Main
ER  - 
TY  - JOUR
A1  - Schmitz, Sylvia
A1  - Moeller, Andreas
A1  - Wilke, Max
A1  - Malzer, Wolfgang
A1  - Kanngiesser, Birgit
A1  - Bousquet, Romain
A1  - Berger, Alfons
A1  - Schefer, Senecio
T1  - Chemical U-Th-Pb dating of monazite by 3D-Micro X-ray fluorescence analysis with synchrotron radiation
N2  - A confocal set-up for three-dimensional (3D) micro X-ray fluorescence (micro-XRF) was used at the mySpot beamline at BESSY II, which allows compositional depth profiling for various applications. We present results obtained with a confocal 3D micro-XRF set-up for chemical age dating using the U, Th and Pb concentrations of monazite within rock thin sections. The probing volume was determined to be approximately 21 x 21 x 24 mu m(3) for W-L alpha using an excitation energy of 19 keV. The relative detection limits particularly for Pb are below 10 ppm (for Counting times
Y1  - 2009
UR  - http://eurjmin.geoscienceworld.org/
U6  - https://doi.org/10.1127/0935-1221/2009/0021-1964
SN  - 0935-1221
ER  - 
TY  - JOUR
A1  - Wilke, Franziska Daniela Helena
A1  - Schmidt, Alexander
A1  - Ziemann, Martin Andreas
T1  - Subduction, peak and multi-stage exhumation metamorphism: Traces from one coesite-bearing eclogite, Tso Moran, western Himalaya
JF  - Lithos : an international journal of mineralogy, petrology, and geochemistry
N2  - Ultrahigh-pressure (UHP), coesite-bearing edogites in the Himalaya have been documented from the Kaghan Valley in Pakistan and the Tso Morani area in northwest India. These complexes are part of the northern edge of the Indian plate that has been subducted to, and metamorphosed at, mantle depths of more than 100 km before being exhumed. Both UHP complexes are located today directly adjacent to the Indus-Tsangpo suture zone and are not separated by non-metamorphosed sequences of Tethyan sediments from the Asian margin. Herein, we present new data for one fresh coesite-bearing eclogite from the Tso Moran massif. Therein, garnets are zoned reflecting their growth during prograde and peak metamorphism and showing a thin retrograde overgrowth. Inclusions can be directly correlated to the compositional zoning and are seen as either relicts of the protolith mineral paragenesis and as "snap shots" of the mineral paragenesis during subduction and under peak conditions. Rare earth element concentrations (REE) were obtained for garnet, mineral inclusions in garnet and matrix minerals. The REE pattern in garnet reflects a sequential change in matrix minerals and their proportions due to net transfer reactions during subduction and peak metamorphism. Using conventional geothermobarometry, a peak pressure of ca. 44-48 kbar at 560-760 degrees C followed by an S-shaped exhumation curve has been deduced. Gibbs free energy minimization modelling was used to supplement our analytical findings. (C) 2015 Elsevier B.V. All rights reserved.
KW  - Tso Morari
KW  - Coesite-bearing eclogite
KW  - Ultra-high pressure (UHP)
KW  - Rare earth element (REE) distribution
KW  - Laser ICP-MS
Y1  - 2015
U6  - https://doi.org/10.1016/j.lithos2015.06.007
SN  - 0024-4937
SN  - 1872-6143
VL  - 231
SP  - 77
EP  - 91
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Oncken, Onno
A1  - Luschen, Ewald
A1  - Mechie, James
A1  - Sobolev, Stephan Vladimir
A1  - Schulze, Albrecht
A1  - Gaedicke, Christoph
A1  - Grunewald, Steffen
A1  - Bribach, Jens
A1  - Asch, Günter
A1  - Giese, Peter
A1  - Wigger, Peter
A1  - Schmitz, Michael
A1  - Lueth, Stefan
A1  - Scheuber, Ekkehard
A1  - Haberland, Christian
A1  - Rietbrock, Andreas
A1  - Götze, Hans-Jürgen
A1  - Brasse, Heinrich
A1  - Patzwahl, Regina
A1  - Chong, Guillermo
A1  - Wilke, Hans-Gerhard
A1  - Gonzalez, Gabriel
A1  - Jensen, Arturo
A1  - Araneda, Manuel
A1  - Vieytes, Hugo
A1  - Behn, Gerardo
A1  - Martinez, Eloy
T1  - Seismic reflection image revealing offset of Andean subduction-zone earthquake locations into oceanic mantle
Y1  - 1999
ER  - 
TY  - JOUR
A1  - Al-Sa'di, Mahmoud
A1  - Jaiser, Frank
A1  - Bagnich, Sergey A.
A1  - Unger, Thomas
A1  - Blakesley, James C.
A1  - Wilke, Andreas
A1  - Neher, Dieter
T1  - Electrical and optical simulations of a polymer-based phosphorescent organic light-emitting diode with high efficiency
JF  - Journal of polymer science : B, Polymer physics
N2  - A comprehensive numerical device simulation of the electrical and optical characteristics accompanied with experimental measurements of a new highly efficient system for polymer-based light-emitting diodes doped with phosphorescent dyes is presented. The system under investigation comprises an electron transporter attached to a polymer backbone blended with an electronically inert small molecule and an iridium-based green phosphorescent dye which serves as both emitter and hole transporter. The device simulation combines an electrical and an optical model. Based on the known highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels of all components as well as the measured electrical and optical characteristics of the devices, we model the emissive layer as an effective medium using the dye's HOMO as hole transport level and the polymer LUMO as electron transport level. By fine-tuning the injection barriers at the electron and hole-injecting contact, respectively, in simulated devices, unipolar device characteristics were fitted to the experimental data. Simulations using the so-obtained set of parameters yielded very good agreement to the measured currentvoltage, luminancevoltage characteristics, and the emission profile of entire bipolar light-emitting diodes, without additional fitting parameters. The simulation was used to gain insight into the physical processes and the mechanisms governing the efficiency of the organic light-emitting diode, including the position and extent of the recombination zone, carrier concentration profiles, and field distribution inside the device. The simulations show that the device is severely limited by hole injection, and that a reduction of the hole-injection barrier would improve the device efficiency by almost 50%.
KW  - conjugated polymers
KW  - high performance polymers
KW  - organic electronics
KW  - organic light-emitting diode
KW  - simulations
KW  - TCAD
Y1  - 2012
U6  - https://doi.org/10.1002/polb.23158
SN  - 0887-6266
VL  - 50
IS  - 22
SP  - 1567
EP  - 1576
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -