TY  - JOUR
A1  - Frodl, Thomas
A1  - Janowitz, Deborah
A1  - Schmaal, Lianne
A1  - Tozzi, Leonardo
A1  - Dobrowolny, Henrik
A1  - Stein, Dan J.
A1  - Veltman, Dick J.
A1  - Wittfeld, Katharina
A1  - van Erp, Theo G. M.
A1  - Jahanshad, Neda
A1  - Block, Andrea
A1  - Hegenscheid, Katrin
A1  - Voelzke, Henry
A1  - Lagopoulos, Jim
A1  - Hatton, Sean N.
A1  - Hickie, Ian B.
A1  - Frey, Eva Maria
A1  - Carballedo, Angela
A1  - Brooks, Samantha J.
A1  - Vuletic, Daniella
A1  - Uhlmann, Anne
A1  - Veer, Ilya M.
A1  - Walter, Henrik
A1  - Schnell, Knut
A1  - Grotegerd, Dominik
A1  - Arolt, Volker
A1  - Kugel, Harald
A1  - Schramm, Elisabeth
A1  - Konrad, Carsten
A1  - Zurowski, Bartosz
A1  - Baune, Bernhard T.
A1  - van der Wee, Nic J. A.
A1  - van Tol, Marie-Jose
A1  - Penninx, Brenda W. J. H.
A1  - Thompson, Paul M.
A1  - Hibar, Derrek P.
A1  - Dannlowski, Udo
A1  - Grabe, Hans J.
T1  - Childhood adversity impacts on brain subcortical structures relevant to depression
JF  - Journal of psychiatric research
N2  - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.
KW  - Depression
KW  - Childhood adversity
KW  - MRI
KW  - Caudate
KW  - Hippocampus
KW  - ENIGMA
Y1  - 2016
U6  - https://doi.org/10.1016/j.jpsychires.2016.11.010
SN  - 0022-3956
SN  - 1879-1379
VL  - 86
SP  - 58
EP  - 65
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Öner, Ibrahim Halil
A1  - Querebillo, Christine Joy
A1  - David, Christin
A1  - Gernert, Ulrich
A1  - Walter, Carsten
A1  - Driess, Matthias
A1  - Leimkühler, Silke
A1  - Ly, Khoa Hoang
A1  - Weidinger, Inez M.
T1  - High electromagnetic field enhancement of TiO2 nanotube electrodes
JF  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - We present the fabrication of TiO2 nanotube electrodes with high biocompatibility and extraordinary spectroscopic properties. Intense surface-enhanced resonance Raman signals of the heme unit of the redox enzyme Cytochromeb(5) were observed upon covalent immobilization of the protein matrix on the TiO2 surface, revealing overall preserved structural integrity and redox behavior. The enhancement factor could be rationally controlled by varying the electrode annealing temperature, reaching a record maximum value of over 70 at 475 degrees C. For the first time, such high values are reported for non-directly surface-interacting probes, for which the involvement of charge-transfer processes in signal amplification can be excluded. The origin of the surface enhancement is exclusively attributed to enhanced localized electric fields resulting from the specific optical properties of the nanotubular geometry of the electrode.
KW  - electromagnetic field enhancement
KW  - photonic crystals
KW  - spectro-electrochemistry
KW  - surface-enhanced Raman spectroscopy
KW  - TiO2 nanotubes
Y1  - 2018
U6  - https://doi.org/10.1002/anie.201802597
SN  - 1433-7851
SN  - 1521-3773
VL  - 57
IS  - 24
SP  - 7225
EP  - 7229
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Sass, Stephan
A1  - Stöcklein, Walter F. M.
A1  - Klevesath, Anja
A1  - Hurpin, Jeanne
A1  - Menger, Marcus
A1  - Hille, Carsten
T1  - Binding affinity data of DNA aptamers for therapeutic anthracyclines from microscale thermophoresis and surface plasmon resonance spectroscopy
JF  - The analyst : the analytical journal of the Royal Society of Chemistry
N2  - Anthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an undisputed key role in cancer treatment, but their chronic administration can cause severe side effects. For precise anthracycline analytical systems, aptamers are preferable recognition elements. Here, we describe the detailed characterisation of a single-stranded DNA aptamer DRN-10 and its truncated versions for DOX and DRN detection. Binding affinities were determined from surface plasmon resonance (SPR) and microscale thermophoresis (MST) and combined with conformational data from circular dichroism (CD). Both aptamers displayed similar nanomolar binding affinities to DRN and DOX, even though their rate constants differed as shown by SPR recordings. SPR kinetic data unravelled a two-state reaction model including a 1 : 1 binding and a subsequent conformational change of the binding complex. This model was supported by CD spectra. In addition, the dissociation constants determined with MST were always lower than that from SPR, and especially for the truncated aptamer they differed by two orders of magnitude. This most probably reflects the methodological difference, namely labelling for MST vs. immobilisation for SPR. From CD recordings, we suggested a specific G-quadruplex as structural basis for anthracycline binding. We concluded that the aptamer DRN-10 is a promising recognition element for anthracycline detection systems and further selected aptamers can be also characterised with the combined methodological approach presented here.
Y1  - 2019
U6  - https://doi.org/10.1039/c9an01247h
SN  - 0003-2654
SN  - 1364-5528
VL  - 144
IS  - 20
SP  - 6064
EP  - 6073
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -